#Goal Setting 2025
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lifeisblogging · 15 days ago
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Achieve Your Best Year Yet with the Journal Planner 2025 + Affirmation Flashcards
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Are you ready to make 2025 your most productive and fulfilling year yet? Meet your ultimate planning companion: The Journal Planner 2025 + 12 Affirmation Flashcards. This isn’t just any planner���it’s a powerful toolkit crafted to help you map out your year, set achievable goals, and stay inspired every step of the way.
Why Choose the Journal Planner 2025?
1. Comprehensive Planning Layouts This planner covers all the essentials, from monthly overviews and weekly breakdowns to daily schedules. You can map out your month with purpose, keep track of weekly to-dos, and use daily prompts to maintain focus on what matters most.
2. Goal-Setting & Progress Tracking Start your year by setting impactful goals. The Journal Planner 2025 includes guided sections to help you establish both short-term and long-term objectives. Plus, built-in progress tracking lets you celebrate small wins and adjust your goals as you go. Whether it’s career growth, personal well-being, or creative projects, this planner is designed to support you.
3. Time Management & Productivity Boosts One of the biggest challenges in achieving our goals is finding the time and focus to work on them. The Journal Planner 2025 incorporates effective time-blocking, priority checklists, and productivity prompts to help you maximize your time. You’ll be amazed at how organized and motivated you feel each day!
The Bonus: 12 Affirmation Flashcards
As a special bonus, each Journal Planner 2025 includes 12 Affirmation Flashcards one for each month of the year. These flashcards are more than just beautiful designs; they’re crafted to keep you centered and positive. Imagine starting each month with a new affirmation to guide your mindset, encourage gratitude, and build resilience.
These affirmations are your monthly reminders to stay grounded, reflect on your journey, and keep pushing toward your dreams.
BUY NOW
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nirvanaida · 4 months ago
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“if you don’t vote blue our democracy will be destroyed” literally what democracy. the united states can barely be called democratic atp.
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fraisefille33 · 10 days ago
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Finally switched from making vision boards for the next year to the next couple years and now I feel way less stressed. I’m always miserable at the end of the year because I didn’t achieve what I wanted to. Realistically I was trying to do things that weren’t going to happen in just a year. Allowing myself to make goals that may take more than a year has to be one of the best decisions I’ve ever made.
Not everything can be done immediately. And that’s okay.
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thethingything · 1 month ago
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there are like 12 weeks of 2024 left so it's time to make a bunch of polls on Simply Plural to try and figure out what the fuck our new year's resolutions for 2025 are gonna be because ideally we should not leave that until the last minute and then get a ridiculous number of alters to vote at once on December 31st again.
I imagine a lot of the suggestions will be similar to this year's ones because we've enjoyed the ones we decided on, but it'll be interesting to see what we come up with. we're thinking about doing another Big Drawing but maybe going with 1 hour a week instead of 2.
we might also do something similar to Bread Quest but with a different category of food, but I'm not sure which one. Fruit Quest and Candy Quest were both suggested last time, and Cheese Quest could be an option, but we'll see what happens I guess.
after checking back, I've just realised we forgot about like half of this year's goals, but it has been a chaotic year so it is what it is. one of them was to pick a new species each week to learn a bunch of facts about, and we didn't do that but we've definitely learned to identify a fuckload of species so we did something at least somewhat related to that
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silvermoon424 · 1 year ago
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I reblogged a post about this before, but again:
THIS IS WHY WE NEED TO COME OUT IN DROVES TO VOTE THIS YEAR AND NEXT YEAR. VOTE BLUE NO MATTER WHO OR ELSE WE WILL BE LIVING UNDER THE FOURTH REICH.
Republicans are a fascist hate group and their playbook for 2025 is the total overthrow of life as we know it (as shitty as this life is) for something far, far worse. Do not be lured into a false sense of complacency or think that "well, the Dems are just as bad." Like yeah, of course the Dems fucking suck but they're not going to federally outlaw contraception/abortion and being queer, among many other things.
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This thread is incredibly important to read.
It is also extremely difficult to read. I don't know if I need to point this out, but the document itself is obviously full of bigotry so please take care of yourself if you choose to read it. Antisemitic phrases like "cultural marxism" and "global elites" appear before the document even really gets rolling, and are mixed in with transphobia, racism, and more.
If you want a taste of how this document starts in the first main section about "The Family", here is a taste:
"This starts with deleting the terms sexual orientation and gender identity (“SOGI”), diversity, equity, and inclusion (“DEI”), gender, gender equality, gender equity, gender awareness, gender-sensitive, abortion, reproductive health, reproductive rights, and any other term used to deprive Americans of their First Amendment rights out of every federal rule, agency regulation, contract, grant, regulation, and piece of legislation that exists."
It is all bad. ALL of this document is bad, and dangerous, and threatens the lives and the safety of everyone living in this country.
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themelanindigitalwave · 3 days ago
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✨ Every step forward is a step toward your dreams. ✨
Don't let the year end without making progress on your goals, kings and queens! 👑 2025 is just around the corner, and it's time to start taking those steps towards the online business you've been dreaming of.
Whether it's launching your own website, creating killer content, or mastering social media marketing, every action you take brings you closer to success.
Need help staying focused and organized on your journey? The Melanin Digital Wave has the perfect tools to help you turn your dreams into reality! Our Journals and Planners are designed specifically for Black entrepreneurs, with prompts, trackers, and inspirational quotes to keep you motivated every step of the way.
➡️ ⬅️
Ready to make 2025 your year? Let's go! 🚀
Save this post for a daily reminder to keep moving forward! 📌
Drop a "🙌🏾" in the comments if you're ready to crush your goals!
Share this post with your squad and let's level up together! ✊🏾
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legallotus · 13 days ago
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Setting Intentions for 2025: A Guide to Goal Setting and Vision Planning
setting intentions for 2025, goal setting, vision planning, personal development, goal setting strategies, roadmap to success
As we approach the end of the year, it’s the perfect time to reflect on the past and set clear intentions for the future. Whether you’re a business owner, professional, or someone focused on personal development, creating a vision for 2025 can help you align your goals and move forward with purpose. Instead of waiting until January to start thinking about your New Year’s resolutions, October is a…
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girlwithrituals · 24 days ago
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GLOW UP GUIDE FOR 2025⠀
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READ: On average, it takes more than 2 months before a new behavior becomes automatic — 66 days to be exact. And considering that 2025 is precisely these many days away, why not start with our glow up plan already?
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Physical Glow Up-
BODY
— 5-10K steps a day.
— 7-8 hours of sleep.
— workout everyday for 1 hr atleast- yoga/stretching/pilates/cardio. a workout may take one hour, but your mood will be boosted for the next 12 hours.
— posture training.
— sunlight exposure after waking up for at least 10 minutes.
NUTRITION
— 2-3 liters of water every day.
— limit your caffeine intake.
— avoid sugars as much as you can.
— high protein diet, pre and probiotics.
— more fruits and veggies (+ green smoothies if you like).
— no junk/processed food/trans fat.
— no eating after 8 pm.
SKINCARE
— be clear on your skin type (oily, dry, combination, sensitive).
— once you're clear, use these accordingly- cleanser, toner, targeted serum, eye cream, moisturizer, sunscreen (≥50 spf).
— keep your bedding clean as well.
— no picking of skin on your lips, cuticle etc.
— gua sha to help improve blood circulation and lessen toxins.
— cold therapy may take three to five minutes of being uncomfortable, but your energy levels will be boosted for the rest of the day.
— remove makeup before you go to bed.
BODY CARE
— shower every day.
— exfoliate 2x a week.
— use body lotion (shea butter/aloe vera gel/coconut oil).
HAIR CARE
— wash hair 2-3x a week
— oil your scalp 2x a week, at least 3 hours before shampoo.
— hair mask 1x per week.
— never brush wet hair.
— use silk pillow case.
HYGIENE
— brush your teeth 2x a day, clean tongue and the roof of the mouth daily.
— floss daily.
— cut your nails 1x a week, never remove the cuticles.
— glycolic acid under arm for odor and discoloration.
— never use soap on your coochie.
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Mental Glow Up-
MINDSET
— set clear goals- define and breakdown your aspirations.
— start your mornings with positive affirmations.
— surround yourself with uplifting content and people.
— be shamelessly selfish to your career and mental health, remove anyone or anything that doesn't align with your priorities and wellbeing.
— boost your brain health by these 4 neuroscience tools:
difficult first: start your day with the most difficult task (cortisol and dopamine are high in the body meaning that your body/mind is primed to work).
rest your eyes: introduce a micro-pause after learning by resting/closing your eyes - will help retain information better.
tomorrow's worries: write tomorrow's to-do list before bed as it is proven to be effective in helping you fall asleep.
find time to play: engage in low-stake play. can be anything you find fun but where the outcome doesn't matter (induces neuroplasticity + reduces stress).
MIND
— meditation might take as low as ten minutes, but your focus will be improved for the rest of the day.
— no social media after waking up and at least an hour before bed.
— keep aside 1 hr of time to read daily! reading a new book may take five hours, but you will keep the knowledge forever.
— journaling, gratitude.
— digital detox once a week or for 12 hours.
— limit unnecessary screentime, unfollow or cut off people you don't want to see.
JOURNALING
— choose a regular time each day to journal, making it a part of your routine.
— find a quiet, comfortable place free from distractions. light a candle if you want.
— allow your thoughts to flow without censoring or editing.
— write about your feelings and emotions to understand them better. write about things you are thankful for to boost your mood. write about your short-term and long-term goals. identify what triggers certain emotions or reactions
— set a timer for 5-10 minutes and write continuously during that time.
— reflect on both positive experiences and challenges.
— make lists, journal your thoughts on these questions.
— journal at night to clear your mind before bedtime, because emotions and thoughts lose their power once we acknowledge them.
— a gratitude practice may take five minutes, but your mindset will be shifted for the rest of the day.
AFFIRMATIONS
— customise affirmations to your needs.
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Personal Life-
WEEKLY TASKS
— initiate small changes: begin with small, manageable tasks such as making your bed or cleaning your room every sunday.
— celebrate your success: reward yourself when you achieve your goals or have a consistently productive week. consider treats like buying flowers for yourself or watching your favorite show.
DAILY WORK
— set achievable goals: establish realistic goals for the day, week, or month ahead.
— track your progress.
— organise your work space, declutter your shelves etc.
— embrace the power of lists: keep a list of tasks to be done and their deadlines. this way, you start each day with a clear plan. to make it visually appealing and motivating, consider using productivity apps like evernote, habit tracker, or notion.
PRODUCTIVITY TIPS
— wake up early.
— plan ahead everything, do scheduling. you can use:
google calendar / notion / tasks .
— if the task takes less than 2 minutes to finish, do it immediately.
— countdown rule, if you are procrastinating, count 1-2-3-4-5 and jump.
— start slow, don't rush and try to do everything at one time.
— follow a proper routine, use app locks based on screentime.
— pomodoro technique, 25 min work, and 5 min break.
— schedule longer break times as well e.g 30 min nap.
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afeelgoodblog · 1 year ago
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The Best News of Last Week
1. ‘We are just getting started’: the plastic-eating bacteria that could change the world
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In 2016, Japanese scientists Oda and Hiraga published their discovery of Ideonella sakaiensis, a bacterium capable of breaking down PET plastic into basic nutrients. This finding marked a shift in microbiology's perception, recognizing the potential of microbes to solve pressing environmental issues.
France's Carbios has successfully applied bacterial enzyme technology to recycle PET plastic waste into new plastic products, aligning with the French government's goal of fully recycling plastic packaging by 2025.
2. HIV cases in Amsterdam drop to almost zero after PrEP scheme
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According to Dutch AIDS Fund, there were only nine new cases of the virus in Amsterdam in 2022, down from 66 people diagnosed in 2021. The organisation claimed that 128 people were diagnosed with HIV in Amsterdam in 2019, and since 2010, the number of new infections in the Dutch capital has fallen by 95 per cent.
3. Cheap and drinkable water from desalination is finally a reality
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In a groundbreaking endeavor, engineers from MIT and China have designed a passive solar desalination system aimed at converting seawater into drinkable water.
The concept, articulated in a study published in the journal Joule, harnesses the dual powers of the sun and the inherent properties of seawater, emulating the ocean’s “thermohaline” circulation on a smaller scale, to evaporate water and leave salt behind.
4. World’s 1st drug to regrow teeth enters clinical trials
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The ability to regrow your own teeth could be just around the corner. A team of scientists, led by a Japanese pharmaceutical startup, are getting set to start human trials on a new drug that has successfully grown new teeth in animal test subjects.
Toregem Biopharma is slated to begin clinical trials in July of next year after it succeeded growing new teeth in mice five years ago, the Japan Times reports.
5. After Decades of Pressure, US Drugmaker J&J Gives Up Patent on Life-Saving TB Drug
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In what can be termed a huge development for drug-resistant TB (DR-TB) patients across large parts of the world, bedaquiline maker Johnson and Johnson said on September 30 (Saturday) that it would drop its patent over the drug in 134 low- and middle-income countries (LMICs).
6. Stranded dolphins rescued from shallow river in Massachusetts
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7. ‘Staggering’ green growth gives hope for 1.5C, says global energy chief
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The prospects of the world staying within the 1.5C limit on global heating have brightened owing to the “staggering” growth of renewable energy and green investment in the past two years, the chief of the world’s energy watchdog has said.
Fatih Birol, the executive director of the International Energy Agency, and the world’s foremost energy economist, said much more needed to be done but that the rapid uptake of solar power and electric vehicles were encouraging.
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That's it for this week :)
This newsletter will always be free. If you liked this post you can support me with a small kofi donation here:
Buy me a coffee ❤️
Also don’t forget to reblog this post with your friends.
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santaeofficial · 3 months ago
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Santae's Kickstarter Goes Live August 30th!
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Our Official Pre-Launch Kickstarter Page has now been made live to preview!  Watch our Kickstarter Trailer and see what we are bringing to Santae in Beta and Beyond! <3
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Kickstarter Link
On-Site Kickstarter Tiers Preview Link Royal Knight Tier Contents Regal Harmony Tier Contents Dark Sovereign Tier Contents Grand Arcanist Tier Contents
Kickstarter Add-Ons
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Kickstarter Stretch Goals
We are thrilled and excited to share with you our pre-launch page which has some of the details of what we're hoping to accomplish in the future with your direct support! In return for backing our Kickstarter, we are offering a wide range of rewards, such as; Animated HA-wearables, exclusive avatars and items, and magical pet species! From the honor-bound  Royal Knight tier, through to the magical Grand Arcanist tier, we believe we have crafted an assortment of content bound to enhance your Santae experience! 
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We're also going to be offering limited-quantity tiers for you to have a direct influence of the content on Santae, by working with our Art & Development teams to create hair styles, Minimals, item sets and even an NPC in your image or design!
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Our goal is $20,000, but we have planned an assortment of Stretch Goals that include some exciting features and updates that we want to bring to Santae, such as:  Pet Backgrounds/Auras, Adventure Party System, and even.. Pet Plushies Merch (To name just a few!).
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Our campaign launch date is 30th August and will run until 30th September!
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With your help, we will hit the ground RUNNING in BETA, with a transition into FULL RELEASE in 2025, with continuous, ongoing updates (as you have seen during Alpha!) to make these features a reality. We still have our referral contest going on until August 25th, Sign up today <3
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We thank each and every one of you for your support! Remember to hit the "Notify Me" button on our Kickstarter page and to tell your friends and family all about us! We are so excited to see what the future holds! Enter our Upcoming Kickstarter Contest being held onsite very soon! We are releasing a new pet species and a brand new pet color!
Thank you all so much for your continued support, we love you all and cannot wait to see what the future holds for all of us!
~The Santae Team
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maplesyrupsainz · 3 months ago
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˖⁺。˚⋆˙under their wings | OB87˖⁺。˚⋆˙
pairing: ollie bearman x fem y/n reader (she/her)
genre: social media au, established relationship
warnings: 2025 grid, teen reader (18)
summary: in which your taken under the wings of the other wags during your first half season as the youngest wag in the paddock 💓
a/n: loveeee this request omg had to write it straight away!! kind of short but think it fits :)
request!!!: smau fic set in 2025 in which ollie bearmans gf is quite young like 18/19 and people just react to how young the two of them are compared to the other drivers and wags?? like her hanging out with kika and alex and people just thinking it’s very cute they’re taking her under their wing ❤️
my masterlist
fc: agathe renou
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instagram ->
olliebearman 📍 melbourne
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liked by estebanocon, charles_leclerc, and others
olliebearman in the points for the first race of the season! 😎
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user1 omgggg i alr love the 2025 season
user2 same i love having ollie on the grid fr
user3 so cute is that his gf on the last slide
estebanocon a great first race!
olliebearman a true pleasure :)
charles_leclerc congratulations ollie ❤️
olliebearman thanks father🥹
alexandrasaintmleux 😂
user4 so obsessed with them
user5 the other drivers r all so sweet to ollie 🥺
oscarpiastri what a first race of the season!
olliebearman means too much 🤍
landonorris congrats!! keep pushing 👊
olliebearman 'preciate it 🔥
yourusername 🥹soso proud of u
olliebearman couldnt do it without you x
twitter ->
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instagram ->
yourusername
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liked by olliebearman, lilymhe, and others
yourusername 🦒 we've been travelling!!
tagged: olliebearman
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user11 ppl who r new to ollie & y/n, welcome 😎
lilymhe your hair is everyyyyythingggg !!
yourusername im blushing soso badly
francisca.cgomes u little beauty <3
yourusername 🥹🥹
alexandrasaintmleux the cutest!!!
yourusername lyyy
user12 omg the wags r so sweet
user13 omg squealing at all the wags
user14 it's too cute omg
charles_leclerc is that toffee the giraffe?
yourusername yea omg lolll embarrassing much
charles_leclerc embarrassing?! do you know who you're talking to 🤔
olliebearman true
alexandrasaintmleux yup
user15 HAHAH this is so cute & funny
user16 toffee the giraffe omg im obsessed
olliebearman love my favs!!
yourusername kisses from me & toffee :))
user17 too adorable 😭
f1wagupdates
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liked by user11, user2, user8, and others
f1wagupdates every time ollie bearman's girlfriend y/n y/l/n has been seen out in public with other f1 wags!
1. y/n out shopping with pierre gasly's girlfriend & model, kika gomes!
2. y/n seen for lunch with carlos sainz's wag & model, rebecca donaldson
3. y/n seen out in nyc with alex albon's girlfriend and golfer, lily muni he
4. y/n seen out again with kika gomes and alexandra saint mleux, charles leclerc's model & art enthusiast girlfriend ❤️
tagged: yourusername, francisca.cgomes, iamrebeccad, lilymhe, alexandrasaintmleux
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user18 omg i love themmmm
user19 this is jus the sweetest thing
user20 i love how they've taken her under their wing!!
user21 fr coz she must've been so nervous in the f1 paddock especially coz she's soo young
user22 fr i feel like there's barely any super young drivers on the grid atm for her & ollie to bond with
user23 literally omg it's so sweet of the wags <3
user24 how old is y/n?
user25 18 🥹
user26 oh to be y/n
user27 built in besties 😭
user28 i'd kill to be in the paddock with this wag lineup
user29 fr it's so iconic
user30 y/n & ollie being the grid babies and everyone adopting them is so personal to meeee
twitter ->
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instagram ->
yourusername posted a story
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liked by francisca.cgomes, olliebearman, and others
alexandrasaintmleux aww our lil babies 🥹💓
yourusername 😂 you & charles are taking the parent thing very literal
alexandrasaintmleux it's a very important job!
olliebearman love you baby
yourusername i love uuu
user32 me when omg
user33 goals much
landonorris he's such a simp
yourusername dont be a meanie lando!!
landonorris my bad. it's my natural instinct
yourusername i know but dont u worry ur little head! ur getting better 😇
olliebearman
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liked by yourusername, charles_leclerc, and others
olliebearman little life update
tagged: yourusername
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user34 toffee!!!
user35 toffee & y/n appearances <33
user36 cant expect much else from an ollie post 😂
user37 true
arthur_leclerc catch up during summer break? 😎
olliebearman yes definitely ! 👍
francisca.cgomes the y/n pic did not disappoint!
olliebearman 😂 you guys are in love with my girl!
alexandrasaintmleux not true we can just appreciate true art :)
yourusername oh guys ur making me blush
olliebearman your beauty transcends language
yourusername ???
olliebearman nvm. charles told me to put that
alexandrasaintmleux 😂😂😂
user38 LOLLLL omg charles leclerc rizz
user39 i love these 2 😭
estebanocon what a season so far
olliebearman 🕺
user40 hahahaha love them
yourusername posted a story
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liked by lilymhe, iamrebeccad, and others
lilymhe i hear you girl 😴
yourusername need ollie to myself for once 😂
lilymhe literallyyyyy! f1 is exhausting!
alexandrasaintmleux same i can't go through border control again i might breakdown
yourusername yup. like ask me my reason for travelling one more time 👊
alexandrasaintmleux 😂😂😂
user41 so gorgeous
user42 ur glowinggg
liked by yourusername
user43 we'll miss u during break!!
olliebearman can't wait to spend summer with you my loveee 🥰
yourusername a well deserved rest baby 💓
yourusername 📍 hungary
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liked by olliebearman, estebanocon, and others
yourusername that's that done (for now) 🥰
tagged: olliebearman
view all comments
estebanocon so great having you in the garage this season!
yourusername thanks for making us feel so welcome estie 🥹
user44 too cute
user45 she's too stunning wow
lilymhe once again, your hair 😻
yourusername 🙈
charles_leclerc im sure we'll be seeing you both during the break
yourusername i imagine so 😇
carlossainz55 here's to summer break 🥂
liked by yourusername
francisca.cgomes 😘 im sure me & pierre will find u in europe this summer
yourusername oh 100% 💓
user46 she's made so many friends it's adorable 🥹🥹🥹
user47 ily y/n i wish i was uuuu
user48 my fav wag fr
user49 same she's won my heart so fast
olliebearman will be a summer to remember im sure ❤️ love you so much
yourusername ☀️ i love you!!
THE END 🤍
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failbettergames · 3 months ago
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We are giddy to announce that we are working with tabletop roleplaying legends Magpie Games to create Fallen London: The Roleplaying Game, a fully-fledged, custom tabletop roleplaying system for Fallen London, in a big book and everything!
In Fallen London: the Roleplaying Game, players create their own characters by drawing on the factions, archetypes, and settings of the city — cutthroats, socialites, radicals, academics, and other, stranger creatures. They are brought together by a shared ambition; a very nearly unachievable goal. Such ambitions may destroy or drive mad those who pursue them… or they may change London forever. The Heart, as they say, is Destiny’s engine.
Fallen London: The Roleplaying Game is slated for release in late 2025 along with a supplement, Fallen London: Secrets of the Neath. In addition, players will be able to complete their tools for gameplay with the Fallen London Dice Pack and Fallen London Gamemaster Screen. Gameplay will consist of proprietary game mechanics currently in development by Magpie Games. We're going to introduce the project in full on August 23rd at 16:00 EDT/21:00 BST in a live stream, hosted by friend, scholar, journalist, streamer and Doctor of the Internet Kat Brewster on their Twitch channel! [PLEASE NOTE: Dear friend Johnny Chiodini has had to drop out at the last minute so utter hero Kat is picking up the host mantle and therefore the location of the Q&A has changed, go to that link instead!]
Guests will include Mark Diaz Truman and Brendan Conway from Magpie, and Fallen London creative lead Bruno Dias and me, Hannah, the one who sends the emails.
Fallen London is turning 15 in 2025 and this is our big anniversary project. We wouldn't have got here without you; we hope that this is a suitable anniversary present. 
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reasonsforhope · 4 months ago
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"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.
The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.
Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.
Tell us about the trial and what it set out to achieve
The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.
Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.
The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.
The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.
Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...
The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.
In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.
During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.
By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...
What is the significance of these trials?
This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.
There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...
For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.
HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.
For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.
What happens now?
The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the ���injectable” or oral TDF or oral TAF groups.
They will be offered the choice of PrEP they would prefer as the trial continues.
A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.
It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.
How long until the drug is rolled out?
We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.
The World Health Organization will also review the data and may issue recommendations.
We hope then that this new drug will be adopted into WHO and country guidelines.
We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.
Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.
Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.
In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."
-via The Conversation, July 3, 2024
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read-marx-and-lenin · 5 months ago
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When a liberal says "Project 2025 will become reality if Trump wins", what they mean is "Liberals are incapable of putting up meaningful resistance to conservative politics".
If the other guy winning is enough to make every far-right policy proposal a reality, then what does that say about your side, hm? Because either the Democrats have the capacity to fight the Republicans in Congress and in the courts, or they don't. If they don't, we shouldn't be acting like they're our only hope to stop the Republicans and we should be looking to other alternatives. If they do, then Biden losing the election isn't enough for them to achieve every single pie in the sky policy goal they have set for themselves.
Biden's low poll numbers are the fault of him and his campaign. The refusal of the Democrats to even entertain the idea of nominating someone else shows exactly where their priorities lie. They are perfectly comfortable with Trump winning so long as it means they don't have to capitulate to the demands of their base.
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batboyblog · 4 months ago
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Things the Biden-Harris Administration Did This Week #28
July 19-26 2024
The EPA announced the award of $4.3 billion in Climate Pollution Reduction Grants. The grants support community-driven solutions to fight climate change, and accelerate America’s clean energy transition. The grants will go to 25 projects across 30 states, and one tribal community. When combined the projects will reduce greenhouse gas pollution by as much as 971 million metric tons of CO2, roughly the output of 5 million American homes over 25 years. Major projects include $396 million for Pennsylvania’s Department of Environmental Protection as it tries to curb greenhouse gas emissions from industrial production, and $500 million for transportation and freight decarbonization at the ports of Los Angeles and Long Beach.
The Biden-Harris Administration announced a plan to phase out the federal government's use of single use plastics. The plan calls for the federal government to stop using single use plastics in food service operations, events, and packaging by 2027, and from all federal operations by 2035. The US government is the single largest employer in the country and the world’s largest purchaser of goods and services. Its move away from plastics will redefine the global market.
The White House hosted a summit on super pollutants with the goals of better measuring them and dramatically reducing them. Roughly half of today's climate change is caused by so called super pollutants, methane, hydrofluorocarbons (HFCs), and nitrous oxide (N2O). Public-private partnerships between NOAA and United Airlines, The State Department and NASA, and the non-profit Carbon Mapper Coalition will all help collect important data on these pollutants. While private firms announced with the White House plans that by early next year will reduce overall U.S. industrial emissions of nitrous oxide by over 50% from 2020 numbers. The summit also highlighted the EPA's new rule to reduce methane from oil and gas by 80%.
The EPA announced $325 million in grants for climate justice. The Community Change Grants Program, powered by President Biden's Inflation Reduction Act will ultimately bring $2 billion dollars to disadvantaged communities and help them combat climate change. Some of the projects funded in this first round of grant were: $20 million for Midwest Tribal Energy Resources Association, which will help weatherize and energy efficiency upgrade homes for 35 tribes in Michigan, Minnesota, and Wisconsin, $14 million to install onsite wastewater treatment systems throughout 17 Black Belt counties in Alabama, and $14 million to urban forestry, expanding tree canopy in Philadelphia and Pittsburgh.
The Department of Interior approved 3 new solar projects on public land. The 3 projects, two in Nevada and one in Arizona, once finished could generate enough to power 2 million homes. This comes on top of DoI already having beaten its goal of 25 gigawatts of clean energy projects by the end of 2025, in April 2024. This is all part of President Biden’s goal of creating a carbon pollution-free power sector by 2035. 
Treasury Secretary Janet Yellen pledged $667 million to global Pandemic Fund. The fund set up in 2022 seeks to support Pandemic prevention, and readiness in low income nations who can't do it on their own. At the G20 meeting Yellen pushed other nations of the 20 largest economies to double their pledges to the $2 billion dollar fund. Yellen highlighted the importance of the fund by saying "President Biden and I believe that a fully-resourced Pandemic Fund will enable us to better prevent, prepare for, and respond to pandemics – protecting Americans and people around the world from the devastating human and economic costs of infectious disease threats,"
The Departments of the Interior and Commerce today announced a $240 million investment in tribal fisheries in the Pacific Northwest. This is in line with an Executive Order President Biden signed in 2023 during the White House Tribal Nations Summit to mpower Tribal sovereignty and self-determination. An initial $54 million for hatchery maintenance and modernization will be made available for 27 tribes in Alaska, Washington, Oregon, and Idaho. The rest will be invested in longer term fishery projects in the coming years.
The IRS announced that thanks to funding from President Biden's Inflation Reduction Act, it'll be able to digitize much of its operations. This means tax payers will be able to retrieve all their tax related information from one source, including Wage & Income, Account, Record of Account, and Return transcripts, using on-line Individual Online Account.
The IRS also announced that New Jersey will be joining the direct file program in 2025. The direct file program ran as a pilot in 12 states in 2024, allowing tax-payers in those states to file simple tax returns using a free online filing tool directly with the IRS. In 2024 140,000 Americans were able to file this way, they collectively saved $5.6 million in tax preparation fees, claiming $90 million in returns. The average American spends $270 and 13 hours filing their taxes. More than a million people in New Jersey alone will qualify for direct file next year. Oregon opted to join last month. Republicans in Congress lead by Congressmen Adrian Smith of Nebraska and Chuck Edwards of North Carolina have put forward legislation to do away with direct file.
Bonus: American law enforcement arrested co-founder of the Sinaloa Cartel, Ismael "El Mayo" Zambada. El Mayo co-founded the cartel in the 1980s along side Joaquín "El Chapo" Guzmán. Since El Chapo's incarceration in the United States in 2019, El Mayo has been sole head of the Sinaloa Cartel. Authorities also arrested El Chapo's son, Joaquin Guzman Lopez. The Sinaloa Cartel has been a major player in the cross border drug trade, and has often used extreme violence to further their aims.
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astonmartinii · 8 months ago
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it's got to be time travel | charles leclerc social media au
pairing: charles leclerc x fem footballer!reader
face claim: jessie fleming (i'm a chelsea fan and i'm sad she left :()
they've got all the time in the world for each other, don't ask them where they got that time from though
note: we're also gonna pretend that the women's football and f1 seasons line up here lol
MASTERLIST | TIP JAR | MY SMALL BUSINESS
charles_leclerc
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liked by landonorris, lewishamilton and 1,203,784 others
tagged: yourusername
charles_leclerc: last sunday lunch before we both have to go back to work :(
view all comments
user1: ffs why do their ACTUAL jobs have to get in the way of my regularly scheduled charles x y/n content???
user2: i personally think that the fia should just give charles the championship and y/n the WSL title so they can just chill together :)
maxverstappen1: not on my watch
charles_leclerc: you don't even follow me? get out of my comments
maxverstappen1: you can't just get given the championship because you have attachment issues WE ALL HAVE ATTACHMENT ISSUES
charles_leclerc: me i get, but y/n doesn't deserve to win?
maxverstappen1: i never said that. y/n is girlboss slay queen
yourusername: too right i am
charles_leclerc: why are you peace and love with her and not me?
maxverstappen1: she's cool, you aren't
yourusername: can't disagree with that babe soz
user3: i have a feeling that these spats might get worse the longer charles is separated from y/n
user4: waa waa we're all sad their being separated but all i'm thinking is UP THE CHELS
user5: i need the treble right fucking now, a charles championship would be a bonus i guess
lewishamilton: will i get a formal introduction to y/n before we're teammates?
yourusername: YES, YES YOU WILL
charles_leclerc: i guess that answers that
lewishamilton: don't hate the player, hate the game
yourusername: i better see your ass at kingsmeadow at some point, it's fun, even if others think they're too good for it
lewishamilton: i'll be there 🫡
user7: can 2025 come quick.... PLEASE
user8: lol does this mean that charles has offered to take carlos to a game but he didn't go?
user9: ugh what a bore
yourusername
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liked by charles_leclerc, oscarpiastri and 1,402,667 others
tagged: chelseafcw
yourusername: excited for the new season back with the girlypops :))))))
view all comments
user10: treble or nothing I BEG
user11: it's their year for the champions league i've seen the script
alexalbon: no seatbelt ? way to set dangerous examples to your young audience
yourusername: if you're not careful i'm gonna teach my audience how to put their foot up the ass of those annoying her
alexalbon: ugh i hope you lose :P
yourusername: i don't have to hope, i know your ass ain't gonna be in q3
alexalbon: that's TOO far @charles_leclerc does our years of friendship mean nothing?
charles_leclerc: sorry buddy, i am y/n stan first, human being second
yourusername: as he should.
user12: so like... will we see charles in a y/n jersey again in the paddock?
user13: @ferrari stop being so annoying and let him wear what he wants
user14: i think i tasted paradise when they actually let him wear a y/n canada jersey in montreal
charles_leclerc: never seen someone make blue look so good
maxverstappen1: i'm right here?
sebastianvettel: did the homoeroticism of our challenge videos mean nothing?
danielricciardo: do not lie to yourself
yourusername: sorry sluts, you wish you looked this good
charles_leclerc: they'll never be you 🫶🏻
user15: i know the cfcw admin and pr department have a heart attack every time y/n posts
user16: the way she's out here calling three f1 drivers sluts with no repercussions
yourusername: can't be told off for telling the TRUTH
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f1
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liked by lewishamilton, fernandoalo_oficial and 1,205,489 others
tagged: charles_leclerc & yourusername
f1: couple goals! charles leclerc takes pole in bahrain while his girlfriend, y/n y/ln, scored the winner for chelsea women!
view all comments
user19: okay but i've never been in a relationship and am currently rotting on my couch... so who is the real winner here x
yourusername: my handsome boy is so talented :3
charles_leclerc: not as talented as you, pretty girl
yourusername: nuh uh at least my team is competent
charles_leclerc: errrrr
samkerr20: i think you broke him lol
yourusername: sometimes i think he's more loyal to ferrari than me
charles_leclerc: no!
scuderiaferrari: huh?
charles_leclerc: wait...
yourusername: i see :(
charles_leclerc: i'm LOGGING OUT
user20: charles is so lover boy stuck in his tortured poets department (ferrari formula one team)
user21: the way he's probably yelling down the phone to y/n about how much he loves her right now
samkerr20: he is and it's so loud the whole locker room can hear it
yourusername: but he's so sweet isn't he
niamhcharles17: i guess?
alexalbon: we heard it from his side... barf
yourusername: @lilymunhe are you being starved of romance?
lilymunhe: compared to you and charles YES
alexalbon: ummmm get out of my business y/ln
yourusername: you're ALWAYS in my business buster 🤨
alexalbon: NO! i am just passing down the ancient skill of communication?
yourusername: you're such a gossip girl alex
user21: i know they bicker like siblings, but i know deep down that there have been double dates
charles_leclerc: yes, but y/n and i are much better (no offence lily)
yourusername: did you log back in to restart the argument with alex
charles_leclerc: yes!
alexalbon: boo you whore
yourusername: don't talk to him like that 🤨
samkerr20
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liked by yourusername, charles_leclerc and 303,445 others
tagged: yourusername & charles_leclerc
samkerr20: forced to hang out with the straights... they're actually kind of cute
view all comments
user22: you know the couple has to be real cute when even the gays think they're cute
user23: no one can resist the charms of y/n and charles
yourusername: these photos make me think that we are cuter
samkerr20: we are but i didn't want to hurt charles' feelings
charles_leclerc: consider them hurt
samkerr20: boo hoo
yourusername: noooooo i love you xxx
charles_leclerc: hehehehehehehe i love you too xxx
yourusername: i miss you, hurry up and win and come home to me
charles_leclerc: i'm doing my best :(
yourusername: you are the bestest boy
samkerr20: STOP THAT MAKES HIM SOUND LIKE A DOG
oscarpiastri: when will australians stop being victims of this relationship
danielricciardo: this is your first season dealing with them properly, buckle up
oscarpiastri: i'm in a relationship but they make me feel so lonely
maxverstappen1: you get used to it after a while
yourusername: we're right here
landonorris: let us commiserate in peace
charles_leclerc: ??? do you or do you not get free football tickets out of it?
landonorris: yeha but when we go we just have to watch you cry when y/n inevitably wins another trophy
charles_leclerc: I'M PROUD OF HER AND YOU WON'T SHAME ME FOR THAT
user24: chelsea women players must be so confused when these grown men start arguments in the comments of THEIR posts
yourusername
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liked by alexalbon, charles_leclerc and 1,529,556 others
tagged: charles_leclerc
yourusername: weekend off... you know what that means
view all comments
user25: i know there's over 1.5 million likes but how can i gatekeep y/n?
user26: for real
charles_leclerc: the best weekends are with you here
yourusername: i may have a love/hate relationship with this team, but the catering is banging (i may have to move to italy)
chelseafcw: NO MENTIONS OF LEAVING CHELSEA, NOT EVEN A JOKE - NOTHING!
yourusername: okay, sorry guys (the pasta was so good though)
charles_leclerc: not even for me?
chelseafcw: DEFINITELY NOT FOR YOU, WATCH OUT OR WE'LL BLACKLIST YOU FROM KINGSMEADOW
yourusername: okay, let's pedal this back. i'm not leaving london and we all still love charles, right admin?
chelseafcw: .... yes
user27: when you're in a who has attachment issues with y/n y/ln and your competition is the chelseafcw admin and charles leclerc
user28: no point even showing up
maxverstappen1: i for one am glad when y/n is in the paddock because it means i can sneak in without the cameras seeing me
yourusername: i am a woman of the people
charles_leclerc: she's such a star, everyone wants to see her
maxverstappen1: yeah i'll give you that
yourusername: we're also hot
charles_leclerc: don't you dare respond to that one max
maxverstappen1: 🫡🫡🫡
user29: patiently waiting for the hq photos of them 😚
user30: gonna print them out and put them in my heart locket
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charles_leclerc
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liked by landonorris, yourusername and 1,398,452 others
tagged: yourusername
charles_leclerc: babe is top of the league (and top scorer)
view all comments
user33: get yourself a guy who flexes your achievements as much as charles does
user34: setting the example tbf
yourusername: my lucky charm, that hat-trick was for you xx
charles_leclerc: would mean more if you didn't score them every week 😭
yourusername: they hate to see a girlboss winning
charles_leclerc: wanna share some wins with me?
yourusername: you're doing great this season babe, not your fault that nasa decided to rebrand to red bull racing
redbullracing: adrian says thanks 😊
charles_leclerc: DON'T SAY IT Y/N
yourusername: you don't even know what i was going to say
charles_leclerc: ....
yourusername: @redbullracing you got a seat???
charles_leclerc: Y/N!!!!!!!!!!
yourusername: whoops
user35: y/n really out here trying to get charles that damn seat
yourusername: i'll stop when the horse team makes a championship worthy car that they don't break halfway through the season...
user36: add ferrari to the group of people who shudder in fear when y/n posts
chelseafcw: fine... we hope you enjoyed (no more italy jokes)
charles_leclerc: i had a great time, i always do when i watch y/n do what she loves (slay)
yourusername: awwwwwwwwww i love you charlie
chelseafcw: okay no need to make admin feel that lonely, damn
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yourusername
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liked by charles_leclerc, alexalbon and 1,782,309 others
yourusername: finishing my best ever season with a big trophy haul :) now time to support my trophy husband in his day job
view all comments
user41: she really be out here doing it all
user42: i need her to win the Ballon d'Or Féminin PLEASE IT IS TIME
user43: with charles in attendance, first couples red carpet appearance YES, YES RUN IT TO ME PLEASE
charles_leclerc: unbelievably proud of you, mon amour, constantly inspired by you
yourusername: i love you so much, thank you for being there to support me through it all
charles_leclerc: it's the biggest pleasure in the world
yourusername: i'm all out of winning this season, your turn next weekend?
charles_leclerc: for you, i'll do anything
user44: PLEASE I NEED HIM TO WIN GOOD PLEASE
alexalbon: congrats i guess, you're pretty good
yourusername: thanks, since my boyf is so supportive, it's only natural that you have to try and humble me at every turn
alexalbon: you're more famous than us now, we need to keep you grounded
lilymunhe: don't worry y/n he cried nearly just as much as charles when you won the WSL
yourusername: I KNEW IT
charles_leclerc: i still cried more
alexalbon: it's not a competition bro, we all know you're both helplessly in love
yourusername: that we are
charles_leclerc
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liked by maxverstappen1, yourusername and 1,309,855 others
tagged: yourusername
charles_leclerc: happiest when i'm with you (and whoever has decided to tag along), oh and winning a race helps as well i guess
view all comments
user45: CHARLES WIN I REPEAT A CHARLES WIN WE WON?
user46: the way y/n went just as mental as us, her and zecira jumping around the garage (and starting the champagne shower after the podium)
user47: really proving that y/n and charles really are each other's biggest fans
user48: thank the lord the WSL season finished when it did so y/n could be there for this win
user49: y/n would've ran to austria to be there i'm sure
yourusername: you know it 🫡
maxverstappen1: had to let you win so you could look cool in front of your infinitely cooler girlfriend
charles_leclerc: not even gonna bite, i'm too happy to care
yourusername: i'll bite - HIS TALENTED BEHIND SCHOOLED YOUR ASS
maxverstappen1: but i called you cool?
yourusername: i'll accept the compliment now, i had to defend charles' honour first
charles_leclerc: heheheehe i'm blushing
maxverstappen1: gross
user50: i need y/n to permanently be in the ferrari garage, they were on it today (i think out of fear)
landonorris: damn i thought i thirdwheeling lestappen was bad, but y/n and charles is a different beast
yourusername: we're both athletes, need to savour the time we have together when we can
charles_leclerc: sorry not sorry you'll get it when you're in love
landonorris: .... i guess i'll die then
fin.
note: i hope you enjoyed !!!! one last WIP to go and good lord the writers block is kicking my ass. but f1 being back should help!!! + f1 academy, much enjoyed it so far.
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