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jcmarchi · 12 days ago

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Noninvasive imaging method can penetrate deeper into living tissue

New Post has been published on https://thedigitalinsider.com/noninvasive-imaging-method-can-penetrate-deeper-into-living-tissue/

Noninvasive imaging method can penetrate deeper into living tissue

Metabolic imaging is a noninvasive method that enables clinicians and scientists to study living cells using laser light, which can help them assess disease progression and treatment responses.

But light scatters when it shines into biological tissue, limiting how deep it can penetrate and hampering the resolution of captured images.

Now, MIT researchers have developed a new technique that more than doubles the usual depth limit of metabolic imaging. Their method also boosts imaging speeds, yielding richer and more detailed images.

This new technique does not require tissue to be preprocessed, such as by cutting it or staining it with dyes. Instead, a specialized laser illuminates deep into the tissue, causing certain intrinsic molecules within the cells and tissues to emit light. This eliminates the need to alter the tissue, providing a more natural and accurate representation of its structure and function.

The researchers achieved this by adaptively customizing the laser light for deep tissues. Using a recently developed fiber shaper — a device they control by bending it — they can tune the color and pulses of light to minimize scattering and maximize the signal as the light travels deeper into the tissue. This allows them to see much further into living tissue and capture clearer images.

This animation shows deep metabolic imaging of living intact 3D multicellular systems, which were grown in the Roger Kamm lab at MIT. The clearer side is the result of the researchers’ new imaging method, in combination with their previous work on physics-based deblurring.

Credit: Courtesy of the researchers

Greater penetration depth, faster speeds, and higher resolution make this method particularly well-suited for demanding imaging applications like cancer research, tissue engineering, drug discovery, and the study of immune responses.

“This work shows a significant improvement in terms of depth penetration for label-free metabolic imaging. It opens new avenues for studying and exploring metabolic dynamics deep in living biosystems,” says Sixian You, assistant professor in the Department of Electrical Engineering and Computer Science (EECS), a member of the Research Laboratory for Electronics, and senior author of a paper on this imaging technique.

She is joined on the paper by lead author Kunzan Liu, an EECS graduate student; Tong Qiu, an MIT postdoc; Honghao Cao, an EECS graduate student; Fan Wang, professor of brain and cognitive sciences; Roger Kamm, the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering; Linda Griffith, the School of Engineering Professor of Teaching Innovation in the Department of Biological Engineering; and other MIT colleagues. The research appears today in Science Advances.

Laser-focused

This new method falls in the category of label-free imaging, which means tissue is not stained beforehand. Staining creates contrast that helps a clinical biologist see cell nuclei and proteins better. But staining typically requires the biologist to section and slice the sample, a process that often kills the tissue and makes it impossible to study dynamic processes in living cells.

In label-free imaging techniques, researchers use lasers to illuminate specific molecules within cells, causing them to emit light of different colors that reveal various molecular contents and cellular structures. However, generating the ideal laser light with certain wavelengths and high-quality pulses for deep-tissue imaging has been challenging.

The researchers developed a new approach to overcome this limitation. They use a multimode fiber, a type of optical fiber which can carry a significant amount of power, and couple it with a compact device called a “fiber shaper.” This shaper allows them to precisely modulate the light propagation by adaptively changing the shape of the fiber. Bending the fiber changes the color and intensity of the laser.

Building on prior work, the researchers adapted the first version of the fiber shaper for deeper multimodal metabolic imaging.

“We want to channel all this energy into the colors we need with the pulse properties we require. This gives us higher generation efficiency and a clearer image, even deep within tissues,” says Cao.

Once they had built the controllable mechanism, they developed an imaging platform to leverage the powerful laser source to generate longer wavelengths of light, which are crucial for deeper penetration into biological tissues.

“We believe this technology has the potential to significantly advance biological research. By making it affordable and accessible to biology labs, we hope to empower scientists with a powerful tool for discovery,” Liu says.

Dynamic applications

When the researchers tested their imaging device, the light was able to penetrate more than 700 micrometers into a biological sample, whereas the best prior techniques could only reach about 200 micrometers.

“With this new type of deep imaging, we want to look at biological samples and see something we have never seen before,” Liu adds.

The deep imaging technique enabled them to see cells at multiple levels within a living system, which could help researchers study metabolic changes that happen at different depths. In addition, the faster imaging speed allows them to gather more detailed information on how a cell’s metabolism affects the speed and direction of its movements.

This new imaging method could offer a boost to the study of organoids, which are engineered cells that can grow to mimic the structure and function of organs. Researchers in the Kamm and Griffith labs pioneer the development of brain and endometrial organoids that can grow like organs for disease and treatment assessment.

However, it has been challenging to precisely observe internal developments without cutting or staining the tissue, which kills the sample.

This new imaging technique allows researchers to noninvasively monitor the metabolic states inside a living organoid while it continues to grow.

With these and other biomedical applications in mind, the researchers plan to aim for even higher-resolution images. At the same time, they are working to create low-noise laser sources, which could enable deeper imaging with less light dosage.

They are also developing algorithms that react to the images to reconstruct the full 3D structures of biological samples in high resolution.

In the long run, they hope to apply this technique in the real world to help biologists monitor drug response in real-time to aid in the development of new medicines.

“By enabling multimodal metabolic imaging that reaches deeper into tissues, we’re providing scientists with an unprecedented ability to observe nontransparent biological systems in their natural state. We’re excited to collaborate with clinicians, biologists, and bioengineers to push the boundaries of this technology and turn these insights into real-world medical breakthroughs,” You says.

“This work is exciting because it uses innovative feedback methods to image cell metabolism deeper in tissues compared to current techniques. These technologies also provide fast imaging speeds, which was used to uncover unique metabolic dynamics of immune cell motility within blood vessels. I expect that these imaging tools will be instrumental for discovering links between cell function and metabolism within dynamic living systems,” says Melissa Skala, an investigator at the Morgridge Institute for Research who was not involved with this work.

“Being able to acquire high resolution multi-photon images relying on NAD(P)H autofluorescence contrast faster and deeper into tissues opens the door to the study of a wide range of important problems,” adds Irene Georgakoudi, a professor of biomedical engineering at Tufts University who was also not involved with this work. “Imaging living tissues as fast as possible whenever you assess metabolic function is always a huge advantage in terms of ensuring the physiological relevance of the data, sampling a meaningful tissue volume, or monitoring fast changes. For applications in cancer diagnosis or in neuroscience, imaging deeper — and faster — enables us to consider a richer set of problems and interactions that haven’t been studied in living tissues before.”

This research is funded, in part, by MIT startup funds, a U.S. National Science Foundation CAREER Award, an MIT Irwin Jacobs and Joan Klein Presidential Fellowship, and an MIT Kailath Fellowship.

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bi-writes · 2 months ago

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attached | ghost x f!reader

i have no idea what it is that binds us together. but it doesn't really matter.

type: one-shot (8.4k)

cw: zombie apocalypse au, mature language and content, suggestive language and content, dark!ghost, dark!reader, reader described as curvy/plus-sized + has hair long enough to braid, graphic depictions of violence + murder + gore, depictions of suicidal thoughts + intentions (no actual action), mentions of depression + sadness + loneliness, depictions of assault + harassment (not by ghost), horror movie vibes, unprotected piv, allusions to baby trapping, cumplay, oral (fem!receiving), 18+

Death can be a curious thing. It used to be something definitive. Exact. It used to mean the end of something.

No, now it's a beginning. Not a sweet beginning, but a beginning nonetheless. It turns a new tide. Reactivates cells that were once dead. Sparks nerves that used to be dormant, that used to be dark. It makes muscles move even when they aren't supposed to. Brain-dead, but still hungry.

He hasn't been able to understand the phenomenon quite yet. He's tried. He's picked up a few books and tried to do his own research, but it's difficult when there is no way for him to view the cellular structure of it all on a micro-level. He cannot see the way it grows or how it takes over. He hasn't been able to figure out what techniques it uses to keep a body awake even when the central organs no longer function the way they're supposed to. What keeps it moving? What keeps the feet running and the stomach hungry and the saliva warm?

Why is it that when he plunges his blade through its heart, it still kicks? The brain is its engine, as with his own body, but this is different. The brain runs even when it has lost its necessary components. Blood circulation, oxygen, the things it needs to thrive; but this state of being is not like his own. It doesn't need the same things it used to need because its purpose is not to keep a body running. Its purpose is to eat. To infect. And that is all.

He likes to play games these days. He has a lucky silver euro, one he pried off the dead body of someone that he hated. He spit on that body before raiding his pockets. He hated that fucking brute; he disgraced the style of wearing a mask by using a fucking t-shirt instead. Perhaps Austria is a beautiful country, but it certainly produced one of the most unlikable of men. He thinks even if the world was still right-side up, he would've killed him anyway. The only thing useful about him was that he was carrying a few extra magazines and this coin in his front pocket.

Every morning, when he wakes up, he makes whatever will happen that day a game. If the coin lands on heads, he gets to kill himself today. If it lands on tails, he has to endure 24 more hours before he can play again. The rules are simple. The game is easy. Everyone knows how to play it, but not everyone will like to win it.

Today, he decides to do something different. Today, he decides if he wins, he will wait another day. He has never won this game; he decides if he can't win it, he'll manipulate it until he gets what he wants.

It hits the table with a light clink. It rattles around in a few circles before settling, and when he leans back in his chair, he sighs. He knows what it will be even without looking, but he looks anyway. When he sees the carved outline of its face-side up, his eyes flash. He won.

He never wins.

Something is keeping him here. He chooses not to ask questions. There isn't anyone to ask anyways. No one answers when he speaks. He doesn't think there is anyone left to listen.

If someone would ask him why he doesn't just put the muzzle to his temple and pull the trigger, he would just say that it was because that was how the game is played. Those are the rules. He can't try unless that's what it tells him to do. There is no fun in cheating the game; it wouldn't be proper, it wouldn't be correct. It would be grounds for disqualification, and that just wouldn't do, not for him.

He has to do things the right way. Always. It's how you keep order in a world that has none left. It's how you maintain structure even without the lines drawn in the sand. This is the way things are done; God is not waiting at the end of a very long staircase, He is rattling that coin on the table and waiting for Ghost to take a peek.

He thinks it keeps landing on tails because perhaps God is tired of playing this game with him; Ghost has never been surprised. He will always be ready for disappointment. Giving a gift is no fun when the recipient simply receives it.

It landed on heads today. He won the game. He tried to play it differently, but someone won't let him.

There's snow on the ground this morning. It snowed all night, coating the ground in a few inches of powdery ice. He looks away from the window and back towards the mirror, continue to run the razor over his head. His blonde hair falls in clumps in the sink. He keeps it neat and short, close to the head, and then he does the same with his face. He cuts the stubble close, keeping his face clean, but it doesn't wipe away the rest of his face, the things he can't just cut away. The scars, the ridges, the skin that closed over wounds angry and white and uneven. He can see his teeth through the broken skin above his lip, the yellowing of them now that he only brushes them a few times a week with his lack of proper toothpaste, and he grimaces when he sees the new red spots of raised skin left behind from the dirty mask he wears now. He dips his toothbrush into his bottle of water before brushing, careful to scrub his gums properly before spitting into the sink.

When he finishes, he makes his way back into the bedroom to get dressed. He did the washing yesterday; he found a creek only half frozen over, and he made use of the bar soap he keeps and managed to clean off most of his clothes. He feels a little better slipping into his cargos now that they aren't drenched in sweat or dirt. He tucks a long-sleeve into his pants before putting a thick windbreaker on over it, but he finally feels complete once he slips his mask on over his face. In the mirror, he adjusts it, making the skull straight, and he blinks back at himself. The mask does more than just hide him from the dead.

It keeps the living walking a careful circle around him, and he wants to keep it that way. He hasn't spoken to a single person since it began. He stopped counting the days once his boots ran out of space for notches. Anyone he sees now, he scares them off with one look, or he puts them down before they can take a step closer to finding out if he's real or not.

He doesn't take chances. He has always had a special skill, being able to sniff out the bullshit before it begins. He leans into it now, and it isn't a bullet wasted if it stops the chaos before it can wind up.

He still wears his tactical gear. He can't part with it. His holsters have not failed him, still buckled around his thighs. His vest is still strapped on, and without it, he feels naked. He has long since discarded of the Union Jack patch on his chest; there is no king nor country anymore. They are colors in different shapes, and they mean nothing now; they were buried a long time ago.

His backpack feels light. He's running out of bullets, and he doesn't like how it feels. Nowadays, he has to go further and further to get what he needs, and recently, he's taken to picking up everything and simply moving to make the trips all the easier with no home to go back to.

It's not all that different to the life he had before. He never stayed in one place too long then either. He signed the shortest leases, and he would move once it was up, never lingering and never buying more things than he could carry in the back of his truck. His memories are in his head and nowhere else. He keeps no trinkets. He saves no pictures. There is nothing from the old life that needs to be brought into the new. He shifts between both lives, one foot in the past and one in the future, and he thinks that's what really makes him live up to his name.

He's a Ghost. A drifter. Standing between two places at the same time, not knowing which to stay in and which to leave. It would hurt, if he was really human inside, if he could feel anything at all.

But he's not. His insides are nothing but organic matter. His head is a clock, ticking, counting down, but he's not aware of when it runs out.

He digs the heel of his boot into the snow to gauge the depth. It barely comes up over his toes. He huffs a little before taking a peek at the map tucked into his vest. He had circled a place just north, a main street he is hoping will have a stash of things he will need.

Ammunition. Weapons. Food. Water. A new book, for fuck's sake, maybe a Sudoku puzzle that isn't already scribbled into.

The forest gives him cover, so he sticks to it. Out in the open, he would stick out, dressed in all black. He keeps to the trees, ducking under the leaves and trying not to leave too much of a track behind. He doesn't plan on staying in that cabin again, but if he must, he doesn't want anyone seeing a way to come back to it.

The one thing he does appreciate about this new place is the quiet. It lingers, and it's calm, and when he breathes, the world breathes back. He feels like he had always been telling everyone to shut up, but now, his voice hasn't been used in months. Even when he passes other people, he doesn't speak to them. If they don't spot him, he keeps to the shadows, and if they do, they don't see him for long enough to know what hit them.

It's a good stash. The store had been rifled through by now, but in the office, there had been a nice drawer filled with supplies. A few boxes of ammunition, a revolver, and a new blade to stick in one of his boots. He picks up some other odds and ends. Batteries. A roll of yarn. A small sewing kit. A few pens. His backpack feels a little heavier, and it's a weight he appreciates when he makes his way back outside.

He sticks to the alleyways as he searches for the roof over his head for the night. He decides the cabin he slept in last night was too close to the road; if anyone was driving or following it, they could find that place too easily, and he wouldn't be able to sleep another night comfortably there knowing this truth.

He finds himself veering off road just enough. It's fucking cold, freezing, and he's grateful to the mask for helping him keep it together as he ducks under the wind and keeps an eye out for any nearby landmarks. Sometimes, on slow days like this, he would sit on a ridge and kill infected for sport. Practice focusing his sight, calculating the wind, keep his mind in check by hitting his targets and ridding the world of another one of those things.

There are different kinds of hunters out today.

He hears them before he sees them. He knows what kind they are when he hears their laughter. Low and untamed, sloppy and fucking messy. They always are. These kind spoil their treasures. They eat their food until it makes them sick, and then they do it all over again. They never learn their lesson.

When he settles his rifle down along a fallen tree, he eyes them through his scope. There are two of them. Both are fattened, with dark hair and lazy eyes, and they look greasy. Their clothes are in ruins, and their packs are light, and Ghost figures that they look enough alike to be perhaps brothers, or maybe cousins. Their smiles are equally as sadistic. The taller one tugs something along, and when Ghost aims the scope down a little, he sees her.

Her.

He's dragging her by her legs. She's kicking, but it's hard for her to do much when her arms and legs are bound by mismatched bits of fabric and rope. She's crying, that much is clear, squirming as she spits and gargles around the gag in her mouth as she tries to break free. She has heart, but she isn’t a fighter. If she was, she would’ve realized her teeth could snap that fabric of her gag, and she would know that the knot they’ve tied succumbs easily to upwards pressure.

He follows them. They keep going, dragging you and laughing as they make it to a makeshift camp hidden amongst a clearing. There's a few tents set up, a small dip in the earth to hold a campfire, and when they settle on tree trunks to sit, the smaller one takes a blade and cuts your gag off, leaning over you with a low chuckle. They mean to maim and to take and then to kill, and you know this when you look into his eyes.

"Hello, darling."

"Bite me."

He laughs again, dropping onto his knees over you, but when he gets close enough, you sit up with what little strength you have and bite him along his ear. The cartilage rips, and you tear half his ear off, and then he's scrambling off of you, screaming, holding the side of his head as he rolls around in circles in the snow. He colors it red, and you snarl with satisfaction. Ghost takes a deep breath in and lets it out shakily. The look in your eyes–he can taste that, roll it around on his tongue. You did not clock the poorly-tied knots, but you do see opportunity, and you are the kind to take it.

"You bitch!"

Just as the taller one is about to get on top of you, Ghost decides he's seen enough. He closes one eye, lines up the sight, and he lets out a cool breath as he drops the both of them within a second of each other. They fall easy; a bullet clean through the back of their heads, and now they're finally quiet again. They will not get up, either.

Your lip trembles as you look towards the trees. You watch as the leaves rustle, and when you see a man emerge from the thick of them, you start to cry. You think maybe you're seeing things; you must be so dehydrated, so hungry, that a reaper has come for you, and you are much deader than you thought.

The reaper stares down at you curiously. He swings his rifle over his shoulder, tilting his head to the side as he bends, getting a blade out of his boot before he cuts the restraints that bind you. He doesn’t hesitate when he does this; he does not deem you enough of a threat to keep you bound.

You sit up slowly, wiping your face, and when you meet his eyes, you're surprised to see how human they are. They're dark, but alive, and he has blonde lashes and pale skin underneath. He covers himself, but you can still see him. There's a man under there, not a reaper.

Just a man.

I hate men.

You shake off the rest of the restraints, turning your wrists and ankles and flexing your muscles for good measure. When you realize you are nothing but a little shaken up, you look back up. He's still staring at you, hard eyes lowered in a glare as he looks you over. He's sizing you up, maybe, deciding what to do with you. You meet his eyes one more time before gathering the saliva into your mouth and spitting onto the floor. It's a garbled mess of blood, from the flesh you had severed from that man.

He blinks slowly at that, makes some decision that he doesn’t voice out loud, and then he starts to walk away.

You stand on shaky legs, taking it as your cue. You watch as he rips open the flimsy tents that those men had left behind, and he's already grabbing backpacks and rifling through them for goods. He already starts filling his own vest and backpack with the things he finds; some flashlights, fishing line, more food and ammunition. You follow him, moving to the other tent beside it and starting to grab their things and toss them outside. You get to your knees and open the packs, laying out what you find carefully. They have interesting materials in here, ones you associate with explosives. C4. Lighters. Batteries. Wiring. You clench your jaw when you pull out the last box in the bag.

Condoms.

Bunch of pricks.

He finds your discoveries useful. He opens up an empty pack he found and fills it to the brim with supplies. When he zips it up, your stomach drops when you think he might toss it over his shoulder and leave. It only sinks for a moment before he turns the backpack around, holding it up for you.

You pause for a little and think. It only takes a few seconds for you to decide to stand up and slip your arms through the straps.

When he walks again, you follow.

The sun is setting by the time you find somewhere to sleep, but it looks like luxury to you. A quaint little brick house tucked between the hills, a ways from the road and positively hidden. He spotted it through his scope a few hours ago, and he made a beeline for it. It's difficult to keep up with him; he has incredible stamina and the longest legs. He moves like a ghost, too quiet for his own good. You would never know from looking at him how stealthy he could be. For such a huge man, you would never notice him before he could get the drop on you. It makes you conscious of your own steps and how loud they are, and you try to mimic the way he moves as you keep walking.

You don't know why, but you think he must be very pleased with how quiet you've gotten. You don't know why that fact pleases you, too.

He makes you stay outside when you arrive. He pulls a small handgun out of his backpack, and he checks the chamber before handing it to you. He clicks his tongue, forcing your eyes on his, and he puts a finger to his mask-covered lips, telling you to keep quiet. You take the gun from him, pointing it at the ground and holding it at your side, and he touches a knuckle under your chin before he twists a silencer onto his own gun.

You watch with rapt attention as he clears the house. His movements are quick and calculated, and he keeps low to the ground. It's mesmerizing. Big and capable, one with the shadows. The only thing you see in the dark is the white of the skull over his face, and if you didn't know it was him, you would think that you have just seen God.

But God isn't real. Apparently ghosts are.

He is back outside in less than ten minutes, nodding his head at you. You take it as your cue to come towards him, and you hand him the gun back when you pass him. You go into the house and immediately start to light some of the candles scattered around. You set your backpack down, rubbing your shoulders out, and you take a seat on the couch.

It hits you then, the gravity of it all. Men are your captors, and then they are your savior. They'll never leave you alone. They'll never let you go. You were ruled by their iron fist in a previous life, and you will endure their wrath in this new one.

You start to cry. It's the first sound you've made since screaming. You cover your face with your hands, and you don't know why you feel safe enough to cry, but you do, and it comes out of you fast.

He tilts his head to the side as he watches you. It's a strange thing to see something so...alive. He's used to only seeing things moving that can't speak back to him. If he does see things alive, he puts them down as if they are rabid dogs.

He can't find it in himself to kill you. Something is so odd about it. About you.

Everything about today seems more than coincidence. He won the game today. And then he found you.

When he tries the sink in the bathroom, he's surprised to find it working. He grabs a bowl and fills it with water, and when he comes back into the living room, you are staring at one of the flickering candles blankly, shivering. You have stopped crying, but your face is still wet with fat, lingering tears.

It looks like you've been hit by a brick wall. Your hair is matted in places, in tangles. It’s in desperate need of a cut. It's stuck to your face around the perimeter, caked by sweat and mud and dried blood. Your clothes are in ruins; you wear a ripped jumper, thin jeans, and the soles of your boots are starting to fray and come off, and he can see where you've tried to mend them unsuccessfully with duct tape. You wear no jewelry, and your fingernails need to be cut. Those men have left marks on you, but those will fade.

He kneels in front of where you sit on the couch. Using a threadbare cloth, he dips it into the water and raises it to your face. You show no resistance. You let him wipe your face off, the tears, the dirt, the blood. It stains the cloth ugly, but you can't look at anything else except for his eyes.

They're so dark. Brown, like bark, like honey. You haven't spoken a word to him yet, but the silence is sort of bliss. All you can hear is the drip of the water when he rings out the cloth.

He helped you. He didn't have to. He could've kept walking, but he stayed with you. He didn't leave you. He could've walked away again, but he let you follow.

He isn't a good man. You know that. Anyone who has lasted this long isn't a good person. You've done the same. You've let it take you, once or twice, let the snarl in the back of your throat guide your hand. You've let the voices fester, let them eat at the acid in your stomach until they begged for more, and you won't admit it, but it felt good. Felt good to protect yourself. To rid the earth of something terrible. To say no.

He must understand that. He's decorated in its essence, the one of understanding, the one that says I know what it's like to take matters into your own hands, and he did it with you, too.

He's doing it now, cleaning you up, and you don't know him, or his face, or his name, but you'll try hard to give it back. To give him something. To tell him you are worthy and not useless. It doesn't show today, how far you've come, but you'll try.

"Thank you," you finally whisper. He's dragging the cloth over your bottom lip, and he blinks rapidly, as if a bit startled by hearing your voice. When you speak again, it's to tell him your name, and he thinks for a few moments before continuing, wiping under your jaw.

He doesn't sleep that night. He stares out the window, like a guard dog, and he lets the soft breaths of your sleep keep him awake.

The gas lighter on the stove still works. It takes a match to light it properly, but when the fire starts, you take some of the soup cans from your pack and make breakfast.

Your smile when he comes into the kitchen nearly blinds him. You look more rested than yesterday, and you ladle some soup into a bowl for him, setting it down at the table. He notices the two bowls, his and yours, and he notices that his bowl has more food.

It is then that he decides to keep you.

What he doesn't know is that you've decided the same. The world has thrown you the way out. A man, built like a bear, happy finger on the trigger and capable of getting you out of harm's way. You need to convince him that you are worthy. You need to convince him that you are valuable. A keepsake.

Men are what start wars, not what end them. Men are the cause of chaos and destruction, it is prevalent throughout history, and it is why you are here now, in a place that doesn’t exist, where people don’t breathe the same air anymore. A man thought himself correct, but he was wrong, and he didn’t listen when someone told him otherwise. They are the ones that take advantage of your vulnerability, and instead of trying to understand it, they use it to get what they want.

You can do the same.

You start by mending his clothes. He's laid some out to dry after washing, and you notice the tears in his shirts. When he comes back a little while later, with dinner hanging off his shoulder, you are seated on the couch, feet tucked under you, with a needle in your hand as you sew up one of his shirts.

You've bathed, found new clothes, warmer ones, and your hair is braided and off your face. He hates to say he prefers you a little dirty, but he likes this, too. A natural beauty. A soft face.

You make a real dinner that night. There's canned vegetables that you try to spruce up with the spices you find in the cupboards, but the real meal is the venison you're served. He butchers it outside like a professional, and he sears it on the stove with a perfect touch. When he feeds you that first bite, your mouth explodes with flavor. Your belly is full that evening, and when he blows out the candles for bed, he eats you out in the dark of the corner bedroom.

He's not sloppy like you thought he might be. Not overeager. He's easy with it, casual. Big hunk of a man smothered between your thighs, and he laves his tongue through your folds like his very own personal dessert. He drinks straight from the source, holy water spilling sweet between his teeth, and when he gets his tongue inside of you and holds it there, you nearly leave earth for somewhere else. You come like that, too, his filthy mouth sucking on your clit before he's slipping that tongue in you again, and you mewl against the bed as he tucks his hand under your ass and spreads you wider.

He tells you his name a few nights later. He doesn't speak, not ever, but when you're crying around his thick fingers, he whispers it against your ear.

"'s Simon," he growls, and you know what he means by that. He wants you to say it while you bounce on his fingers, when you rut against his thigh. He wants you to say his name when you're coming undone riding his face, when you're wetting his mask with your pussy and making him choke on your cum. Such a wet, sweet girl you are, and sometimes he skips wash day for his mask so he can shove it into his mouth and pant around it and taste you while he fucks his own fist.

It's insanity, he thinks, as he's cleaning his rifle. The idea of traditional. But it's what befallen him, what he sees all around him, and he tucks his index finger into a hole too small to pinch himself just to make sure he isn't living a dream. You're in the kitchen, mending more clothes, something warm boiling on the stove. There were seeds in the greenhouse, and you're saving them to plant in the spring, so for now, you make do with canned goods and whatever Simon hunts for during the day. You found books in the attic, and you read them at night, head in Simon's lap as he plays with your hair or rubs your sore ankles or cuts your nails. You're the only one that ever speaks; he hasn't said a word to you except for telling you his name, and you're content to be the only one that uses their voice.

He always listens. You told him one time that you loved the shade of green that the trees wore, and he came back one day with a sweatshirt of the same color for you. He noticed you trying to mend those terrible boots, and he found a new pair for you, your size this time, barely worn and fit for winter. He brings lots of things for you; books, clothes, even rocks sometimes, when he just thinks he found one that you might like.

You do like them. You have started filling a small bowl with the ones he brings, and he notices you rifling through it sometimes, just looking at them, and it makes his chest swell with pride.

Like giving a treat to a dog. Like giving him a fucking bone.

He teaches you how to shoot. You know how to pull a trigger, but that’s the extent of your expertise. He teaches you how to stand, how to turn the safety on and off, how to hold the gun between two hands so not even his own can take it away from you. He makes sounds when you please him. Hums low, lets out a soft breath, sucks in the air through his teeth. You can’t see his face, but the way he looks at you when you fire a bullet and knock bottles off their ledges, it warms you, all the way down your spine, reaching your toes. You want him to keep looking at you this way, so you try hard, and he notices.

You’ll never be what he is, but the small victories are what have him chubbing up in his cargos and falling asleep between your thighs. You give, and he takes, and he keeps coming back for more.

He teaches you that distance is your strength. You aren’t like him; you aren’t built like a brick house, you won’t be bigger than a lot of your opponents. You need to keep them away from you, however you can. He makes you good with that gun because it’s your best chance, but in the even that you lose it or you run out of bullets, he shows you how to aim a hatchet so that the blade always lines up between someone’s shoulders.

The way you listen makes him salivate. The way you blink up at him and say yes, Simon and take his orders, it makes it difficult to keep away from you.

Today marks two months in the house tucked on the hill. Simon hunts, and you cook, and you live in some sick, twisted housewife fantasy at the end of the fucking world. Simon provides, and you keep, and when the box of condoms falls out of your backpack one day, you glance at Simon for just a moment before he's on you.

It's animal, that first time. He tackles you practically onto the carpet of the living room, and he props you up onto your elbows and only pulls down your jeans enough that he can fit his cock between your thighs. You hear the tear of the condom wrapping, and then he's laying over your back, sinking to the base, cock nestled inside of you as he grips your throat gently and fucks you into the carpet. Poor beast, he's definitely going to need his knees massaged after this, but you can't think about that much when you're taking the fattest cock of your entire life and trying to survive underneath him. It's that fine line between pleasure and pain that you're desperate for, and you pull threads out of the carpet as you try to hang on and take it like a good girl.

You can hear his voice. It's low, and subtle, but he grunts with each agonizing thrust, hips snapping against your ass as he fucks you back onto him over and over and over again.

It's primal. Nasty. You wish he wasn't wearing a condom, you want him to be in your skin, you want him to fill you until you're full, let it spill over, and then do it all over again. You want him to bite into your throat and tear, and you want him to eat you and then put you back together, and then do it again and again and again.

"So big," you gasp, and he falters at that. You recognize it, the need for praise, and you latch onto it with claws and stay there. I need him to stay here with me. "So good...so good t-to me, Simon–"

He groans. It's music.

Keep me. Keep me. Keep me.

"Simon, please–" You scratch at his arm, not satisfied until you feel blood. When you break the skin, he laughs, a breathless laugh that has your eyes rolling back in your head as he shoves your face into the carpet and mounts you like a fucking horse. The deep slap, slap, slap of skin is enough to send you away, send you home, your mind foggy as your pussy squeezes him for all he's worth. The slick of the condom is pleasant, but you want it raw. You want every part of him carved into you, and you arch your back, suck him in, whine and cry and beg for him to just, "please, Simon, I need it, I need it."

"Need wot?"

The sound of his voice is whiplash. He hisses when he sinks deep, staying there, holding you at a sharp angle so he can knead your ass and watch it bounce back on him. He sucks on his teeth, and there's drool slipping out of your mouth. That accent, his voice, like velvet, from deep within his chest. You want to hear more of it.

"Be a man," you gasp. "Be a man, and fuck me."

He doesn't see the desperate look on your face when he slips out of you. He doesn't see the relief that washes over you when you hear the condom come off, latex crumbling as he tosses it, but he feels the warmth of your pretty pussy when he sinks back in, skin to skin, and feels you clench for dear fucking life.

"Fuckin' Christ," Simon groans, and you reach back for him, gripping his arms, forcing him to fall over on top of you. He settles with his elbows on either side of your head, and you bow your back and grip the carpet again as he fucks into you nice and slow, deep, fat head leaking precum and making you cry because finally, yes, please, this is it, what I want, I'll have you forever.

You're so pretty. Even in his past life, Simon never got to have anything pretty. He was too ugly, too big, too awkward. Any woman of good faith stayed 100 yards away, as if his mere presence was a warning alarm, some invisible radius that kept them away from him. He always thought it was for the better. He always thought good riddance, they shouldn't have me, I shouldn't have anyone. Not when only days before, he had tortured a Russian militant until he had no teeth and hung his severed fingers on twine around his own neck.

But you won't run away. He's given you opportunity. He's left the cottage and staked out the outside just to watch you, and all he sees is you moving between windows, shaking out the dust from old blankets and washing the dishes. All he sees is you sewing his clothes and cooking his food, and when he comes back inside, all he sees is your smile and your face and your pretty mouth that falls open when he makes you come all over his hand.

Now it's the end of the world, and he lets a coin flip decide whether or not he lives or dies. And even when he flips it now, it never agrees. When he asks to die, the coin tells him no. When he asks to live, it’s always interrupted by you.

Yes, it tells him. Yes, yes, yes, because it's been keeping him here, because it knows, because it saw, because he couldn't see both sides of the coin, but he can see it now, plain as day, and she's underneath him now, letting him inside, and she's begging him to come and to fill her up, and she's crying because he's such a big man, and she wants him everywhere and always and all at once, and Simon is nothing if he isn't an insatiable bastard that can finally be fucking selfish.

The way you say his name could make him move mountains. That soft breath you take. The falter of your voice. The whine. The world has gone quiet, but he'll make a new one, and he will leave it at your feet for you to step on or pick up.

Whichever you choose. You can do no wrong.

When he comes, he moans. Into your ear, he lets you hear him, lets you bask in his pleasure as he spurts hot inside of you, hauling you a little higher on your knees so he can make sure you come, too. He gives you the palm of his hand to grind on, fucking into you at the same time, humming deep when he feels you squeeze around him and shatter like glass.

He takes his mask off for the first time that night. You see his face, all of it, not just glimpses when he lifts it to eat or to drink, you see the whole thing. He has a terrible looking face. Something only a mother could love. Too old of scars to be from this new life. They slash across his brow, across his cheeks. He has a jagged nose, and the skin around his lips had been reconstructed poorly from however they had been slit.

He's a terrifying piece of flesh. He is surprised when you lean in and kiss him. He's even more surprised when you kick off your jeans, turn over, and fuck him again.

The mantra that sounds like mine repeats in his head over and over. He feels it, deep, warm and beating under his ribs alongside his heart that hasn't moved in a long while.

He found you in those woods, kicking amongst predators, and he took you home with him. Picked you up like a stray, fed you, clothed you, and now you've stayed. For a moment, he thought it wasn't real. Thought your full belly is what kept you here, the warm house. He didn't mind pretending, but he figured it wouldn't last.

He doesn't think that anymore. Not with the way you kiss his severed face. You nuzzle into it, cup his cheeks, and he finds it agony when you pull away.

He hovers now. In whatever room you are in, Simon must also be in it. If he leaves, he makes you board the doors, and you are only allowed to open them if he knocks in his special way. He tested you once, came back earlier than expected, and he was so pleased you did not open the door to his casual knock and only the special one that he made you come one, two, three times with your thighs locked around his face.

A terrible thing happens.

Not to you.

You're searching the greenhouse. Hoping to find some flower pots for the herb seeds you found, you're rummaging through the cabinets beside it. Your gun is sitting away from you, and although Simon would chastise you for this, you feel safe here, and it doesn't bother you.

It flings itself at you. It cries, what used to be a teenage girl, reaching for you because it wants a chunk of your softness, of the life you pump into the muscles that keep you running. You're protected by all the clothes you wear for the weather, and it is slow because of the cold freezing their rigid, dead bones, but it does not lessen the hunger, the fight, the determination to eat and spread.

Before it can bite, the back of its head explodes. You close your mouth and shut your eyes as rancid brain matter splatters the white snow and you, and it is wrenched off of you immediately. Simon stands there, his pistol in hand, and you have never seen him quite so angry as he is right now.

His eyes are wild. He heaves under that tact vest, breathing hard, and his grip on the handgun shakes, so much that he has to shove it back into the holster at his thigh and lean over to pick you up off the ground.

He jostles you. Growls. Is nearly an animal himself as he shoves you up against the glass of the greenhouse and snarls.

"Wot the fuck is wrong with ya?!" Simon snaps. "Is y'r fuckin' head on?!"

It's so quiet in your head even as he yells. Your eyes tear, but not because you're upset. You reach out and cup his face gently, and he stops. Stops talking, just watches, just looks at you as he bends and leans his forehead against yours and squeezes you to his chest.

What is this thing you have? What have you become? What innate thing has festered between you? He’s gripping the edge of the glass so hard, you hear it crack under his hand. There is some kind of sick sense of devotion among you. Some kind of responsibility. He’s angry because something under his tongue tasted bitter when he saw you struggling. It won’t be this easy. He won’t make it this easy. If he doesn’t get to die, then neither do you, and he will make sure of that, because that is the only way this game can remain fair.

You never wander to the greenhouse again. He makes you promise (lest he wastes his cum between your thighs instead of inside you, that's it, promise me).

Another terrible thing happens.

Not to you.

They're wanderers. When they knock at the door, they don't use Simon's special knock, so you don't open it. Instead, you blow out the candles and hide, peeking at them from the fogged window in the attic.

They are men (you aren't surprised, they seem to be the only thing that survives nature's heavy hand). Cold. Shivering. One of them is bleeding, you can see it from the blood trail he leaves in the snow that seeps from somewhere under the hem of his jeans. The one uninjured tries to force his way through the door, but Simon added more deadbolts to it, and it doesn't give under his weak attempts. You trade your handgun for the rifle, aiming it at them. If they get through the door, maybe you can draw them back out, keep them away from the house.

You try to stay quiet, but the healthier one uses his body and a log of wood to get through. They're desperate, desperate enough to not care that breaking through the door cuts him severely, splits through his jacket. The second man limps behind him, getting inside, and you decide to put the rifle back.

You will stay quiet until Simon gets back. Your strength is not being a bulldozer, so you'll hide until he can be that for you. You steady your breathing; even if they make it to the attic, you won't go quietly. You tried that last time, and if it wasn't for Simon, you'd surely be naked and dead in that clearing that you were dragged to.

This time, if you go, you will take someone with you at least. Severed ears are not enough. You will not make them artists, you will make them forgettable and unrecognizable, and you will give back what they give you tenfold. Even if it kills you.

It takes them all night before they finally make it to the attic. They eat your food and take showers in your bathroom and stink up the living room, you can hear them. And when their bellies are full and their minds wander, you dread the pull of the attic door as he wrenches it open and the ladder falls.

You manage to kill one as he drags you out from the corner. He latches onto your ankle, and as he pulls, you put your finger on the trigger of your handgun, and you put one right between his eyes. The other takes advantage of your moment of pause, turning you over onto your stomach so hard the gun flies across the attic from your hand. He tosses you down from the attic, and you land on your side in the hallway, and you cry as you get to your elbows and crawl, trying to get to your feet, but he's larger than you.

He catches you in the kitchen. Slams you over the kitchen counter, using his weight to pin you down, but Simon taught you better than that. He taught you not to give in. He taught you not to give up. You think about him when your fingers find the discarded fork on the counter and you drive it right through his fucking eye.

You don't stop. You don't let his cries keep you from bringing your arm down again. And again. And again. You make his face your blank canvas, and you paint it with your anger. For every man that ever touched you. For every man that ever thought himself worthy to have you. For every man that tried to make your body his prize, you poke a thousand holes in him, and you scream with him as you do it until he can't scream anymore.

You're holding the fork and standing over him when Simon comes home. His handgun drawn, silent as he makes his way in, his body visibly relaxing when he sees you. He glances at the man at your feet, still alive, gurgling there, choking on his own blood as he tries to breathe through the holes that are scattered across his face and neck. You meet his eyes, and you smile. It's uncanny to do it now, but you are happy to see him.

"There's..." You sniffle, wiping your face with your sleeve. "There's another i-in the attic."

You don’t get to see him smile under the mask. You don’t hear the near purr that leaves him as he climbs the ladder and sees the perfect place you’ve left your mark. He’d frame it if it wouldn’t rot.

You twirl the fork in your hand before going to the sink, dropping it in there, and you close your eyes as you listen to Simon's footsteps as he goes into the attic. It takes him a little less than an hour to get the bodies out the back door, and when he comes back inside, you're already wiping up the floor in the kitchen.

There's nothing to talk about. This is normal. This is just another day. Tomorrow, you might have to do it again, and you'll still cook dinner after sunset and clean the kitchen like you're doing now and sit Simon on the edge of the bathtub and cut his hair.

Simon found chocolate on his trip today, and you make cake with it. You sit in his lap under the candlelight, and you feed each other, bite by bite, and you giggle when Simon gets it all over his lips.

You kiss him to clean it off, and then you reach for another bite of cake. There's some measure of satisfaction you feel when your tongue finds the dent in the fork prongs from when you used it earlier. The chocolate tastes better somehow. Sweeter.

You catch him in the morning, limbs tangled with yours under the sheets, flipping a coin. You smooth a hand over his thick chest, along his pudgy stomach, and you watch with him as the coin lands on the bedside table, falling flat.

It comes up tails.

He decides then that he doesn't have to flip it anymore. It's pointless. He asked for answers, and he got one.

You were not luck. You were fate. And because of it, the coin will always land the same way.

His thoughts are interrupted when you reach for the coin. You twirl it between your fingers, thinking. He doesn't see what you see, but that's okay. Maybe he'll let you play now. Some other game, a better one.

Heads or tails, win or lose, alive or dead. Either way, you are attached. Woven together, thread by thread. There are no vows to say in this new place, but you aren't tested by the same kinds of things. There is no law to keep two people together, no governing power of men that say if left is truly left and that right is really right.

You are drawn together by shared experiences. The same trauma. You won't leave each other not because you said you wouldn't leave, but because there is no one else in the world that has seen the same things you have seen and has done the same things you have done. There is no one else in the world that will forgive you for what you had to do to survive. That will love you not just in spite of it, but because of it, because you did what was necessary, and you are here now to learn a lesson and not suffer its consequences.

It's just a game. If you win, he wins. If you lose, he loses. If you're alive, he's alive.

And if you're dead, then he must be, too.

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