#Oxidative stress

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Unmasking the Inflammatory Culprits: How Packaged Snacks Sneakily Sabotage Your Health

Let’s face it, we all have a soft spot for snacks. Whether it’s a mid-afternoon energy boost, a comforting treat during a stressful day, or a simple way to satisfy a craving, snacks are an integral part of our lives. However, the convenience and allure of packaged snacks often mask a hidden danger: their potential to fuel chronic inflammation within our bodies. Inflammation, while a natural and…

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At Body Focus Clinic, we are committed to providing top-tier care through alternative medicine in Rockford, Illinois. One of the most promising anti-aging treatments we offer is glutathione therapy. Glutathione is a powerful antioxidant that helps combat oxidative stress, a significant contributor to the aging process. By neutralizing free radicals, glutathione helps protect cells and reduce the visible signs of aging, promoting a more youthful appearance and better overall health.

[openintegrative]

Inflammation: Causes & Effects

Inflammation is the body’s response to injury or infection, but chronic inflammation can lead to health problems.

Iron overload from artificial sources and copper deficiency contribute to chronic inflammation.

Acute inflammation is temporary and protective, while chronic inflammation can cause long-term damage.

Managing inflammation involves dietary choices, avoiding fortified foods, and ensuring sufficient copper intake.

Animal-based foods are vital for reducing inflammation and maintaining nutrient balance.

What is Inflammation?

Inflammation is the body’s response to injury, infection, or harmful stimuli. It presents as redness, heat, swelling, and pain.

Acute inflammation is a short-term reaction that aids in healing and defense. Chronic inflammation, however, can lead to tissue damage and contribute to diseases like heart disease and diabetes.

Causes of Inflammation

Inflammation can be triggered by various factors, depending on whether it is acute or chronic.

Acute Inflammation This type occurs quickly after injury or infection and usually resolves once the threat is eliminated. Common triggers include injuries, bacterial or viral infections, and exposure to irritants.

Chronic Inflammation Chronic inflammation develops over time and can persist for months or years. Dietary factors, such as consuming processed foods fortified with iron, can lead to iron overload, which contributes to oxidative stress and chronic inflammation.

Copper deficiency also plays a role in chronic inflammation, as copper is essential for regulating iron metabolism and reducing oxidative stress.

Symptoms of Inflammation

Symptoms vary depending on whether inflammation is acute or chronic.

Acute Inflammation Symptoms Symptoms include redness, swelling, pain, and heat at the affected site. These are signs that the body is working to repair damage or fight off infection.

Chronic Inflammation Symptoms Chronic inflammation symptoms are often subtle and may include fatigue, joint pain, digestive issues, and unexplained aches.

These symptoms can be exacerbated by factors like iron overload and copper deficiency.

Impact of Inflammation on Health

While inflammation is protective in the short term, it can lead to serious health problems if it becomes chronic.

Short-Term vs. Long-Term Effects Acute inflammation helps in healing and protection against infections. However, prolonged inflammation can contribute to chronic diseases, including cardiovascular diseases, autoimmune disorders, and metabolic conditions.

Iron overload from artificial sources, such as supplements and fortified foods, can worsen these conditions by increasing oxidative stress.

Copper deficiency can impair the body’s ability to manage inflammation, leading to further health complications.

Dietary Influence on Inflammation

Diet plays a major role in either promoting or reducing inflammation.

Pro-Inflammatory Foods to Avoid Avoiding ultra-processed foods that are fortified with iron is important in managing inflammation. These foods can lead to iron overload, which contributes to chronic inflammation.

It’s also beneficial to reduce intake of sugar, refined carbohydrates, and vegetable oils, which can promote inflammation.

Anti-Inflammatory Foods to Include Eat bioavailable whole foods that are naturally rich in nutrients. Foods like grass-fed beef, pastured eggs, and cod liver oil provide essential fatty acids and vitamins that help reduce inflammation.

Including copper-rich foods such as liver and shellfish helps maintain the necessary balance between iron and copper, preventing deficiencies that can exacerbate inflammation.

Iron Overload and Copper Deficiency

Understanding the roles of iron and copper in the body is key to managing inflammation.

Understanding Iron Overload Iron overload, particularly from artificial sources like fortified foods and supplements, contributes to oxidative stress and chronic inflammation.

Unlike iron obtained from natural food sources like red meat, artificial iron can accumulate in the body and cause harm.

This condition, often exacerbated by genetic factors like hemochromatosis, can lead to severe health problems if left unmanaged.

The Role of Copper Deficiency Copper is essential for reducing inflammation and regulating iron levels. A deficiency in copper can lead to increased oxidative stress, impaired immune function, and difficulty managing iron levels, all of which contribute to chronic inflammation.

Ensuring adequate copper intake through diet is vital for maintaining health and preventing inflammation.

Lifestyle Factors Affecting Inflammation

Several lifestyle factors play a role in managing inflammation.

Physical Activity Regular physical activity helps reduce inflammation by improving circulation and reducing stress.

Exercise can also help regulate the immune system and maintain a healthy weight, both of which are important in managing inflammation.

Stress Management Chronic stress is a significant contributor to inflammation. Managing stress through techniques like meditation, deep breathing, and adequate sleep can help reduce inflammatory responses in the body.

Environmental Toxins Exposure to environmental toxins, such as pollutants, chemicals, and heavy metals, can increase inflammation.

Reducing exposure to these toxins by choosing natural cleaning products, avoiding processed foods, and filtering water can help manage inflammation.

Natural Remedies

Natural remedies and supplements can be effective in managing inflammation.

Cod Liver Oil Cod liver oil is rich in omega-3 fatty acids and vitamins A and D, which are known for their anti-inflammatory properties.

Including cod liver oil in your diet can help reduce inflammation and support overall health.

Herbal Supplements Herbs like turmeric and ginger have strong anti-inflammatory properties and can be effective in reducing chronic inflammation.

These natural supplements can be incorporated into the diet through teas, extracts, or culinary use.

Managing Iron and Copper Levels Balancing iron and copper intake is important for managing inflammation. Avoiding fortified foods and unnecessary iron supplements helps prevent iron overload, while consuming copper-rich foods ensures that iron levels remain in check.

Copper supplementation may be necessary to restore balance and reduce inflammation.

Conclusion

Chronic inflammation poses significant health risks, but it can be managed through dietary choices, lifestyle changes, and natural remedies. Avoiding artificial sources of iron, ensuring adequate copper intake, and focusing on nutrient-dense animal-based foods helps reduce inflammation and support overall health.

FAQ

How does iron overload contribute to inflammation? Iron overload, particularly from artificial sources like fortified processed foods and supplements, increases oxidative stress, leading to chronic inflammation and associated health problems.

What are the signs of copper deficiency? Signs include fatigue, weakened immune function, and difficulty regulating iron levels. Copper deficiency can also contribute to chronic inflammation.

Can dietary changes help manage iron overload? Yes, avoiding artificially fortified foods and iron supplements, and instead obtaining iron from natural food sources like red meat, can help manage iron overload.

How do I balance iron and copper in my diet? Include copper-rich foods like liver and shellfish, and be mindful of your iron intake, avoiding artificial sources to prevent overload.

What lifestyle changes can reduce inflammation? Regular physical activity, stress management, and minimizing exposure to environmental toxins are key strategies to reduce inflammation.

Research

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Bo, S., Durazzo, M., Gambino, R., Berutti, C., Milanesio, N., Caropreso, A., Gentile, L., Cassader, M., Cavallo-Perin, P. and Pagano, G., 2008. Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults ,. The Journal of Nutrition, [online] 138(2), pp.305–310. https://doi.org/10.1093/jn/138.2.305.

Boddaert, N., Le Quan Sang, K. H., Rötig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J., Munnich, A., & Cabantchik, Z. I. (2007). Selective iron chelation in Friedreich ataxia: Biologic and clinical implications. Blood, 110(1), 401-408. https://doi.org/10.1182/blood-2006-12-065433

Collins, J. F. (2021). Copper nutrition and biochemistry and human (patho)physiology. Advances in Food and Nutrition Research, 96, 311-364. https://doi.org/10.1016/bs.afnr.2021.01.005

Cornelissen, A., Guo, L., Sakamoto, A., Virmani, R. and Finn, A.V., 2019. New insights into the role of iron in inflammation and atherosclerosis. EBioMedicine, [online] 47, pp.598–606. https://doi.org/10.1016/j.ebiom.2019.08.014.

DiNicolantonio, J.J., Mangan, D. and O’Keefe, J.H., 2018. The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency. Journal of Metabolic Health, [online] 3(1). https://doi.org/10.4102/jir.v3i1.43.

Fillebeen, C., Descamps, L., Dehouck, M.-P., Fenart, L., Benaïssa, M., Spik, G., Cecchelli, R. and Pierce, A., 1999. Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier. Journal of Biological Chemistry, [online] 274(11), pp.7011–7017. https://doi.org/10.1074/jbc.274.11.7011.

Gaetke, L., 2003. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology, [online] 189(1–2), pp.147–163. https://doi.org/10.1016/s0300-483x(03)00159-8.

Galaris, D., Barbouti, A. and Pantopoulos, K., 2019. Iron homeostasis and oxidative stress: An intimate relationship. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, [online] 1866(12), p.118535. https://doi.org/10.1016/j.bbamcr.2019.118535.

Greenberg, G.R. and Wintrobe, M.M., 1946. A LABILE IRON POOL. Journal of Biological Chemistry, [online] 165(1), pp.397–398. https://doi.org/10.1016/s0021-9258(17)41250-6.

Gutteridge, J.M.C. and Halliwell, B., 2018. Mini-Review: Oxidative stress, redox stress or redox success? Biochemical and Biophysical Research Communications, [online] 502(2), pp.183–186. https://doi.org/10.1016/j.bbrc.2018.05.045.

Harris, Z. L., Durley, A. P., Man, T. K., & Gitlin, J. D. (1999). Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proceedings of the National Academy of Sciences of the United States of America, 96(19), 10812-10817. https://doi.org/10.1073/pnas.96.19.10812

Hentze, M.W., Muckenthaler, M.U., Galy, B. and Camaschella, C., 2010. Two to Tango: Regulation of Mammalian Iron Metabolism. Cell, [online] 142(1), pp.24–38. https://doi.org/10.1016/j.cell.2010.06.028.

Ke, Y. and Qian, Z.M., 2007. Brain iron metabolism: Neurobiology and neurochemistry. Progress in Neurobiology, [online] 83(3), pp.149–173. https://doi.org/10.1016/j.pneurobio.2007.07.009.

Kenkhuis, B., Bush, A.I. and Ayton, S., 2023. How iron can drive neurodegeneration. Trends in Neurosciences, [online] 46(5), pp.333–335. https://doi.org/10.1016/j.tins.2023.02.003.

Kruszewski, M., 2003. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, [online] 531(1–2), pp.81–92. https://doi.org/10.1016/j.mrfmmm.2003.08.004.

Milanino, R., Conforti, A., Franco, L., Marrella, M. and Velo, G., 1985. Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders. Agents and Actions, [online] 16(6), pp.504–513. https://doi.org/10.1007/bf01983655.

Mills, E., Dong, X., Wang, F. and Xu, H., 2009. Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders. Future Medicinal Chemistry, [online] 2(1), pp.51–64. https://doi.org/10.4155/fmc.09.140.

Moos T., Morgan EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol. 2000 Feb;20(1):77-95. doi: 10.1023/a:1006948027674. PMID: 10690503.

Moos, T., Nielsen, T.R., Skjørringe, T. and Morgan, E.H., 2007. Iron trafficking inside the brain. Journal of Neurochemistry, [online] 103(5), pp.1730–1740. https://doi.org/10.1111/j.1471-4159.2007.04976.x.

Muckenthaler MU, Galy B, Hentze MW. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr. 2008;28:197-213. doi: 10.1146/annurev.nutr.28.061807.155521. PMID: 18489257.

Prohaska, J. R. (2011). Impact of Copper Limitation on Expression and Function of Multicopper Oxidases (Ferroxidases). Advances in Nutrition, 2(2), 89-95. https://doi.org/10.3945/an.110.000208

Sorenson, J.R.J., 1989. 6 Copper Complexes Offer a Physiological Approach to Treatment of Chronic Diseases. Progress in Medicinal Chemistry, [online] pp.437–568. https://doi.org/10.1016/s0079-6468(08)70246-7.

Thackeray EW, Sanderson SO, Fox JC, Kumar N. Hepatic iron overload or cirrhosis may occur in acquired copper deficiency and is likely mediated by hypoceruloplasminemia. J Clin Gastroenterol. 2011 Feb;45(2):153-8. doi: 10.1097/MCG.0b013e3181dc25f7. PMID: 20502350.

Uriu-Adams, J.Y. and Keen, C.L., 2005. Copper, oxidative stress, and human health. Molecular Aspects of Medicine, [online] 26(4–5), pp.268–298. https://doi.org/10.1016/j.mam.2005.07.015.

Vashchenko, G., & A. MacGillivray, R. T. (2013). Multi-Copper Oxidases and Human Iron Metabolism. Nutrients, 5(7), 2289-2313. https://doi.org/10.3390/nu5072289

Wang, J. and Pantopoulos, K., 2011. Regulation of cellular iron metabolism. Biochemical Journal, [online] 434(3), pp.365–381. https://doi.org/10.1042/bj20101825.

Wallander, M.L., Leibold, E.A. and Eisenstein, R.S., 2006. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, [online] 1763(7), pp.668–689. https://doi.org/10.1016/j.bbamcr.2006.05.004.

Ward, R.J., Zucca, F.A., Duyn, J.H., Crichton, R.R. and Zecca, L., 2014. The role of iron in brain ageing and neurodegenerative disorders. The Lancet Neurology, [online] 13(10), pp.1045–1060. https://doi.org/10.1016/s1474-4422(14)70117-6.

Xia, Y., Chen, Z., Huang, C., Shi, L., Ma, W., Chen, X., Liu, Y., Wang, Y., Cai, C., Huang, Y., Liu, W., Shi, R. and Luo, Q., 2024. Investigation the mechanism of iron overload-induced colonic inflammation following ferric citrate exposure. Ecotoxicology and Environmental Safety, [online] 275, p.116241. https://doi.org/10.1016/j.ecoenv.2024.116241.

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Understanding RSV in Adults: Symptoms, Risks, and Prevention

Respiratory Syncytial Virus (RSV) is often associated with young children, but it can also pose a significant threat to adults, especially those at high risk. Understanding the symptoms, risks, and prevention strategies can help you protect yourself and others.

What is RSV?

RSV is a common respiratory virus that can cause cold-like symptoms in most people. However, it can lead to more severe illnesses in certain groups, including adults aged 65 and older, people with weakened immune systems, and those with chronic health conditions.

How does RSV spread?

RSV spreads through respiratory droplets when an infected person coughs, sneezes, or talks. It can also live on surfaces for several hours, making it possible to spread through contact.

What are the symptoms of RSV in adults?

Symptoms of RSV in adults often resemble a common cold, but they can be more severe in some cases. These symptoms may include:

Runny nose

Cough

Sore throat

Fever

Fatigue

Shortness of breath

Wheezing

When should I seek medical attention for RSV?

If you experience any of the following symptoms, it's important to consult a doctor:

Difficulty breathing

High fever

Worsening cough

Chest pain or pressure

Wheezing

Who is at higher risk for severe RSV?

Adults at higher risk for severe RSV include:

Older adults (65 and older)

People with weakened immune systems due to illnesses or medications

Individuals with chronic health conditions such as heart disease, lung disease, or diabetes

How can I prevent RSV?

While there's no vaccine specifically for RSV, you can take steps to reduce your risk:

Wash your hands frequently with soap and water.

Avoid close contact with sick individuals.

Cover your mouth and nose when coughing or sneezing.

Get vaccinated against other respiratory viruses like influenza.

If you're at high risk, talk to your doctor about preventive measures.

What are the treatment options for RSV?

There's no specific antiviral treatment for RSV. Most people recover on their own within a few weeks. However, if you have severe symptoms, your doctor may prescribe medications to manage the infection.

Remember: RSV can be a serious illness, especially for high-risk populations. By understanding the symptoms, taking preventive measures, and seeking medical attention when necessary, you can protect yourself and others from this contagious virus.

Would you like to know more about RSV or other respiratory illnesses?

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DNA repair going APE and strand breaks fixing with ATM: please no cash, just redox and contact bases

New research from a team of genome scientists and DNA damage response (DDR) experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments. The new investigaton shows how ATM-mediated signaling is induced by DNA single-strand breaks (SSBs) for DNA damage repair – illuminating the distinct mechanisms of SSB-induced ATM kinase and…

[ardellesplace]

Will Humans Soon Live to 200? A Glimpse into the Future of Longevity. Humanity has always harbored a fascination with longevity, dreaming of a future where the bounds of life extend far beyond our current expectations. Recent scientific advancements suggest that this dream may soon transform into reality.

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Ocuprime for Supplementary Eye Health Support for Vision Ocuprime Vision Care

In today’s fast-paced world, taking care of our eyes is more important than ever. With the rise in screen time and exposure to harmful blue light, our eyes require extra support to maintain optimal health. This is where Ocuprime comes in — a revolutionary supplement designed to provide supplementary eye health support for vision.

Ocuprime contains a potent mix of vitamins, minerals, and antioxidants that work together to nourish the eyes and protect them from oxidative stress. Key ingredients such as lutein, zeaxanthin, and vitamin C help to filter harmful blue light, reduce glare sensitivity, and support overall visual acuity.

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ORGANIC ARGAN CARRIER OIL

It moisturizes the scalp and relieves irritation, which promotes dandruff. It is also a natural anti-bacterial and anti-fungal oil that produces a protective layer on the scalp and prevents dandruff-causing microbes. It strengthens hair from the roots. It stimulates the development of hair follicles and strengthens the hair shaft. Many experts utilize Vitamin E to boost hair growth and tighten the scalp, and Argan Oil contains it. Free radicals create oxidative stress in the organism. Pure Argan Oil contains antioxidants that bind to these free radicals and limit their activity. This procedure may appear modest, yet it strengthens the immune system and protects against chronic illnesses.

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10 facts to understand why glutathione is essential 🙌

Hello everyone ✋ 1.Glutathione is a naturally found antioxidant in our body. It is important to know about this powerful antioxidant because it has a host of many benefits. Its primary function is to fight free radical that damages body cells. It’s vital for the body because it helps to protect from many diseases like autoimmune diseases, liver damage, heart diseases, respiratory diseases and…

[dynamichealthinsights]

The Silent Thief of Youth: Unveiling the Profound Impact of Stress on Aging and Overall Health

Stress, an ever-present companion in our modern lives, can silently chip away at our health and vitality, accelerating the aging process and leaving us vulnerable to a host of ailments. While occasional stress can be motivating, chronic stress acts like a relentless undercurrent, gradually eroding our well-being from the inside out. In this comprehensive exploration, we’ll delve into the…

[huelightusa]

Can Oxidative Stress Be Reversed? A Closer Look

Discover the mechanisms behind oxidative stress, explore evidence-based strategies for combating it, and learn how lifestyle changes and antioxidant-rich diets can help restore balance to your body's cellular health. To learn more, visit https://shorturl.at/dvAFJ.

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5 Beneficial Foods for Fatty Liver to Heal

5 Beneficial Foods for Fatty Liver to Heal Introduction Fatty liver disease, characterized by the accumulation of fat in the liver cells, is becoming increasingly prevalent due to sedentary lifestyles and poor dietary choices. While medical intervention is crucial, dietary modifications play a significant role in managing and even reversing this condition. In this article, we’ll explore five…

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Highlights

•The cardiovascular toxicity of MNPs and plausible mechanisms are explored.

•MNPs can penetrate intestinal or pulmonary barriers and accumulate in the heart.

•Main cardiac effects are abnormal HR, pericardial edema, and myocardial fibrosis.

•Main vascular effects include hemolysis, thrombosis, and blood coagulation.

•MNPs alter the cardiovascular toxicity of other environmental contaminants.

This review unveils that MNPs can disseminate and aggregate in the circulatory system, threatening cardiac function and causing toxicity on (micro)vascular sites. Not only can MNPs generate cardiovascular toxicity, but they also change the toxicological outcomes of other environmental pollutants. The main mechanisms of MNP-driven cardiovascular toxicity are oxidative stress, inflammation, pyroptosis, and the interaction between MNPs and cellular components.