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naturalfactorsb · 3 months ago
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The Liposomal Advantage: Maximizing Vitamin C Benefits for Optimal Health
In the quest for optimal health, Vitamin C is often hailed as a superstar nutrient. Known for its powerful antioxidant properties and immune-boosting benefits, Vitamin C is essential for overall well-being. However, not all forms of Vitamin C are created equal. Enter liposomal Vitamin C, a revolutionary delivery system that maximizes the benefits of this vital nutrient. At NaturalFactors, we’re excited to share how this innovative approach can transform your health.
Understanding Liposomal Technology
So, what exactly is liposomal technology? Liposomes are tiny spherical structures made of phospholipids, the same components that make up our cell membranes. By encapsulating Vitamin C in liposomes, this technology protects the nutrient from degradation and enhances its absorption in the body. This means that more Vitamin C reaches your cells, providing you with greater benefits than traditional forms of supplementation.
Enhanced Absorption for Maximum Benefits
One of the most significant advantages of liposomal Vitamin C is its superior absorption rate. Traditional Vitamin C supplements, such as ascorbic acid, can sometimes cause gastrointestinal discomfort and have limited bioavailability. In contrast, liposomal Vitamin C bypasses these issues, allowing for a smoother and more effective absorption process.
Research has shown that liposomal formulations can increase the amount of Vitamin C that enters the bloodstream, meaning you can achieve optimal levels with a smaller dose. This makes liposomal Vitamin C not only more effective but also gentler on your stomach.
Immune Support Like Never Before
With the rise of seasonal colds and flu, supporting your immune system is more important than ever. Vitamin C plays a crucial role in various immune functions, including the production of white blood cells that combat infections. By choosing liposomal Vitamin C from NaturalFactors, you’re ensuring that your body receives the support it needs to fend off illnesses effectively.
The enhanced absorption of liposomal Vitamin C means that you’ll be providing your immune system with a steady supply of this essential nutrient. This can lead to quicker recovery times and improved overall health, especially during the colder months.
Antioxidant Powerhouse
Vitamin C is renowned for its antioxidant properties, which help neutralize free radicals in the body. These harmful compounds can lead to oxidative stress, contributing to chronic diseases and aging. By incorporating liposomal Vitamin C into your daily routine, you’re empowering your body to fight back against oxidative damage.
The liposomal delivery system ensures that a higher concentration of Vitamin C reaches your cells, maximizing its protective effects. This makes it a fantastic ally in your skincare regimen as well, promoting healthier, more radiant skin by combating environmental stressors.
Convenient and Versatile
Liposomal Vitamin C offers convenience and versatility. Available in liquid form, it can be easily added to smoothies, juices, or simply taken on its own. This flexibility makes it an ideal choice for those with busy lifestyles who still want to prioritize their health.
At NaturalFactors, we understand the importance of quality and convenience. Our liposomal Vitamin C is crafted with the highest standards, ensuring that you receive a premium product that supports your health goals.
Who Should Consider Liposomal Vitamin C?
Liposomal Vitamin C is suitable for a wide range of individuals. Whether you’re an athlete looking to enhance recovery, a busy professional wanting to boost immunity, or anyone interested in maintaining overall health, this form of Vitamin C can be a valuable addition to your daily routine.
Additionally, those who experience digestive discomfort with traditional Vitamin C supplements will find liposomal formulations to be a more pleasant alternative.
Conclusion
As we navigate the complexities of modern health, liposomal Vitamin C emerges as a powerful ally in achieving optimal wellness. With its enhanced absorption, immune support, and antioxidant properties, it’s a game-changer for anyone looking to elevate their health regimen. At NaturalFactors, we are committed to providing you with the highest quality liposomal Vitamin C, ensuring you get the maximum benefits from this essential nutrient. Embrace the liposomal advantage and take a significant step towards better health today!
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bodyfocusclinic · 6 months ago
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Considering an all-encompassing approach to health? Consulting a prolotherapy physician in Chicago, Illinois can open new avenues for enhancing your well-being. Prolotherapy, alongside IV chelation therapy, offers a holistic method to address chronic pain and inflammation, promoting overall body repair and regeneration.
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caringhandsofamerica · 6 months ago
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Keeping track of medications can be challenging, especially for those receiving home care in Manassas, Virginia. Ensuring timely and accurate medication intake is crucial for maintaining health and preventing complications. For many individuals, medication reminders play a vital role in staying on track with their health regimen.
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apexvitals1990 · 1 year ago
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Why Hyaluronic Acid is a Must for Joint Health
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In the world of health and wellness, there are countless supplements and nutrients that claim to improve our overall well-being. However, one compound that has been gaining significant attention is Hyaluronic Acid. This natural substance, found in the fluids of our eyes and joints, acts as a cushion and lubricant, making it a must for joint health. In this blog post, we will delve into the benefits of Hyaluronic Acid and why it should be a part of your health regimen.
What is Hyaluronic Acid?
Hyaluronic Acid is a naturally occurring substance in our bodies. It’s found in high concentrations in the skin, joints, and eye fluids. In the joints, it acts as a shock absorber and lubricant, allowing for smooth movement. Additionally, it plays a crucial role in hydrating the skin and maintaining its elasticity.
Hyaluronic Acid and Joint Health
One of the primary benefits of Hyaluronic Acid is its impact on joint health. It’s a key component of the synovial fluid that surrounds our joints, providing lubrication and reducing friction during movement. This is particularly beneficial for those who engage in regular physical activity or have joint-related conditions.
Improved Mobility
Hyaluronic Acid supplements can help improve mobility by maintaining the health of the joint fluid. This can lead to smoother and more comfortable movement, particularly for those with joint conditions or those who put regular stress on their joints through physical activity.
Reduced Pain
By providing lubrication to the joints, Hyaluronic Acid can also help reduce joint pain. It acts as a cushion, absorbing the impact of physical activity and reducing the strain on the joints. This can be particularly beneficial for those with conditions like osteoarthritis.
Enhanced Recovery
For athletes and fitness enthusiasts, Hyaluronic Acid can aid in recovery. By maintaining the health of the joint fluid, can help speed up recovery after intense workouts, reducing joint stiffness and discomfort.
In the world of health and wellness, there are countless supplements and nutrients that claim to improve our overall well-being. However, one compound that has been gaining significant attention is Hyaluronic Acid. This natural substance, found in the fluids of our eyes and joints, acts as a cushion and lubricant, making it a must for joint health. In this blog post, we will delve into the benefits of Hyaluronic Acid and why it should be a part of your health regimen.
What is Hyaluronic Acid?
Hyaluronic Acid is a naturally occurring substance in our bodies. It’s found in high concentrations in the skin, joints, and eye fluids. In the joints, it acts as a shock absorber and lubricant, allowing for smooth movement. Additionally, it plays a crucial role in hydrating the skin and maintaining its elasticity.
Hyaluronic Acid and Joint Health
One of the primary benefits of Hyaluronic Acid is its impact on joint health. It’s a key component of the synovial fluid that surrounds our joints, providing lubrication and reducing friction during movement. This is particularly beneficial for those who engage in regular physical activity or have joint-related conditions.
Improved Mobility
Hyaluronic Acid supplements can help improve mobility by maintaining the health of the joint fluid. This can lead to smoother and more comfortable movement, particularly for those with joint conditions or those who put regular stress on their joints through physical activity.
Reduced Pain
By providing lubrication to the joints, Hyaluronic Acid can also help reduce joint pain. It acts as a cushion, absorbing the impact of physical activity and reducing the strain on the joints. This can be particularly beneficial for those with conditions like osteoarthritis.
Enhanced Recovery
For athletes and fitness enthusiasts, Hyaluronic Acid can aid in recovery. By maintaining the health of the joint fluid, can help speed up recovery after intense workouts, reducing joint stiffness and discomfort.
Incorporating Hyaluronic Acid into Your Regimen
Hyaluronic Acid can be incorporated into your health regimen in several ways. It’s available as a dietary supplement in capsule or powder form. It can also be found in certain foods, including bone broth, soy products, and leafy greens.
In conclusion, Hyaluronic Acid is a powerful compound that can significantly improve joint health. By providing lubrication, reducing pain, and enhancing recovery, it’s a must-have for anyone looking to maintain their joint health. As always, it’s important to consult with a healthcare professional before starting any new supplement regimen.
Remember, your health is an investment, not an expense. So, invest wisely and take care of your joints with Hyaluronic Acid.
Hyaluronic Acid can be incorporated into your health regimen in several ways. It’s available as a dietary supplement in capsule or powder form. It can also be found in certain foods, including bone broth, soy products, and leafy greens.
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honeytonedhottie · 2 months ago
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taking control of ur wellness (tips and tricks to be ur healthiest most vibrant you)⋆.ೃ࿔*:・✍🏽🌸
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you must treat ur body like the temple that it is. love every inch of urself and out of love for urself, take good care of it. in this post we'll explore how to take control of ur wellness and overall take better care of urself from the inside out…💬🎀
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THE MAINTENANCE ;
maintaining ur health by taking supplements is something that i do and its made a big difference in my health. because im taking my vitamins and supplements i feel a lot better and i dont get sick often at all.
♡ invest in a cute vitamin box to inspire u to take ur vitamins
i take a daily multivitamin in the morning and at night i take magnesium + D3 because its helped me fix my sleep schedule and just have better quality of sleep. plus its a better alternative to melatonin ᡣ𐭩 •。ꪆৎ ˚⋅✍🏽
DISCLAIMER : its crucial for u to do ur own research when it comes to ur health so make sure that u do that before applying anything that u learn on the internet for ur own safety!…💬🎀
♡ chia seed water every morning
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make sure that ur not consuming more than 1-2 tbsp of chia seeds a day but i put 2 tablespoons of chia seeds in my water every morning cuz its an amazing source of fiber, and they're rich in omega-3 fatty acids and other vitamins and minerals.
♡ if im experiencing inflammation i'll take some warm water, turmeric and some lemon
♡ chlorophyll water (bonus points if u add a lemon wedge)
chlorophyll is an internal deodorizer! it helps to detoxify the body by binding to and eliminating toxins, heavy metals, and harmful substances. it also helps with skin concerns like acne 💕
♡ dry brushing
dry brushing is something else that i do that has an impact on my health. dry brushing unclogs pores in the exfoliation process. it also helps detoxify your skin by increasing blood circulation and promoting lymph flow/drainage. so not only am i exfoliating for softer more princessy skin, im also promoting my lymph flow and increasing my blood circulation.
THE IMPORTANCE OF HYDRATION ;
i know everyone always talks about how important it is to drink water and its lowkey overdone but its TRUE. water is so SO important. if u have difficulty drinking enough water invest in a cute water bottle with a straw. i say with a straw cuz i feel like personally, im more inclined to drink water if its out of a straw.
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YOU ARE WHAT YOU EAT ;
when ur eating, try focusing on how the food ur eating is making you feel. everyones body responds differently to different foods so by noticing how u feel after eating something, you can have a better idea of what u should continue eating and what u should steer clear of. with that being said, lets get into this section. 🗒️
something else that i wanted to yap about in this section is that there is a difference between restricting urself and self control. eating shouldn't be bringing u anxiety and ur allowed to let urself live. so eat to feel satiated and happy, dont eat to the point where you feel sick and like u can barely move.
something that has helped me be more conscious of what im choosing to fuel my body with is the 80-20 rule. choose the healthier option 80% of the time and the 20% of the time eat yummy pastries and cakes 💕
if ur someone who has difficulty eating vegetables, try cooking them in a different way and seasoning them adequately to make them yummy, masking them in different dishes. OR if that doesnt work for u get ur veggies in smoothies. cuz u gotta get in some fruits and vegetables.
im someone who loves to have a fun drink in the mornings and during the day so i've been super obsessed with making my own smoothies. my smoothie formula is super simple and it has never failed me.
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(1-2 fruits + collagen powder/protein powder + almond milk + a bit of honey/maple syrup + ice)…💬🎀
some more wellness drinks and juicing recipes →
♡ apple + lemon + kale + honey + water
♡ grapefruit + lemon + kale + water
ALL ABOUT PROBIOTICS ;
probiotics are the good bacteria that live in your gut, working hard to keep your digestive system balanced and healthy. SO if you’re dealing with bloating, fatigue, or even skin issues, it might be time to show your gut some love.
♡ kimchi
♡ greek yogurt
♡ kefir
♡ pickles
♡ kombucha
MOVING YOUR BODY ;
moving ur body is also super duper important, not only for ur physical well being but also for ur mental wellbeing so make sure that ur getting physical activity every single day.
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whether thats going to the gym, stretching, playing a sport, going on walks, dancing etc. there are literally SO many ways that u can move ur body and enjoy urself ᡣ𐭩 •。ꪆৎ ˚⋅ some things that i like to do to stay active are →
♡ dancing ♡ stretching ♡ jump-roping (my favorite) ♡ walking
the trick to this is using the stair master machine OR if u dont have one in ur gym, u can just go on the treadmill at an incline for like 30 minutes or however long u can, and putting ur hands up to ur head and keeping ur posture straight. aim for at least a 5-10% incline, but you can go higher depending on your fitness level…💬🎀
or ofc u can go on walks with ur pet or ✨hot girl walks✨ and walk while listening to a podcast, literally whatever u prefer.
♡ pilates/workouts that i can follow along with on youtube
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a fun way to keep track of the workouts that u consistently do is to make a workout book like i did. that way i can have everything at my fingertips right when i need it 💕🗒️
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prettygirlformula · 2 months ago
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things i do to distract myself.
i dont usually post textposts, but i decided to do something different because, its november!!! nd we all know this months is when things go wrong and i've been struggling to practice self-care so here are some of my favourite things i like to do to remind myself i am loved, and perhaps give you all some inspo if you're in a funk too!! <3
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listen to music i tend to have different playlists as i believe that the music you listen to dictates your mood. as much as i enjoy my jazz and classical, when im in a funk i need to be hype 24/7!! my go to's are usually anything future, miss stallion, glorilla, king von, tate mcrae, charli or carti. i need to listen to music that'll manifest success and confidence.
read i'll read anything really, just to keep my mind off social media BECAUSE I DO NOT WANT TO ROT MY BRAIN WHEN IM FEELING SULKY. im currently reading letters from a stoic by seneca - im learning plenty and its keeping me stay calm
body movement i love a good run, or a pilates sesh so i'll put all my anger and sadness into pushing myself to run an extra k, or that extra set. sometimes its nice to just clear ur lungs and ur mind, and it'll build my strength physically and mentally!!! plus i'll look even better so he'll regret ever ending things with me
visit the beach im a beach girl forever, the ocean has always been my best friend. a quick swim will alwayssss level me out. there's cute boutiques and my favourite açai place along the esplanade and i love walking down there during the sunset or sunrise to keep me busy.
annoy my friends i love my friends so much they're my everything!!! they bring me peace even if we're loud. there's something about surrounding yourself with positive and loving energy that i'll never get tired of, if i could i would give all my love in my body to them.
write ive always been a writer i think. i have to get everything in my mind onto paper or a document or i lose it. its nice to write in my journal about things im grateful for, things im scared about and things i want to achieve. as well as just what went on in my day - i think that now im out of high school im living a much more dramatic and different life to what i used to, so i need to process these things. also i write w a muji pen so it makes the experience so fun.
cry no matter how nonchalant i try to be, im a crier - even at the clubs (it gets embarrassing) but i find it a great way to rid my anger, sadness or stress - better out than in.
meditate ive only just started practicing this, but its very peaceful!! well duh i like to do it during sunset in the park near one of the beaches i frequent (so i can swim too hehe) and the sound of the waves, the people and life can kind of block out anything in my head!!
clean/re-organise my room organised room = organised mind!! (my dad taught me that one) but during this process i always find something that i forgot about and i get distracted, so it takes longer but i get the job #done
call my mummy my mum and i are close, shes my best friend so i tell her everything (except my tattoos and my ehem..rendevouz..) her wisdom has helped me in a lot of situations...i tend to write down the advice she gives me so i dont forget and fuck up. again :p
retail therapy maybe not the most healthy way of self-care, but it gets the job done i cannot lie!! sometimes you need to spend a little bit of money to sustain some peace in your life. you do need that glossier lip liner babe, get it, you deserve it.
ofc some of these things may not work well for you, but self-care is what makes you feel good!!! im open to new ideas of self-care so lmk what you guys do :p + thank you so much for 3 blessed years on this account, eternally grateful for everyone <3
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autisticaradiamegido · 6 months ago
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day 192
a break from artfight for some good news! i have finally scheduled a surgical consult to have my enemy (read: uterus) removed. this is a bit of a scarier prospect than my breast reduction was, but i think it will be an equally impactful quality of life improvement when all is said and done!!
anyway those of yall who have been here since the beginning may remember me posting through that whole process so i figure why stop now.
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baconcolacan · 3 months ago
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YOU! 👉
I just relized you the one who wrote one of my fave fics on Ao3! I need to know if you don't mind, will there be and updates to regimen? It tickles my brain chemicals. No pressure btw <3
Ahahaha yes hello 👋 you found me, the writer of that horribly tragic fanfic
I get asked this a lot, but I dont mind answering it again for people who dont know but, yes I do plan to get back on the writing saddle for Regimen eventually, it’s just a matter of my motivation and willingness to get back into the headspace of that universe. I already have the ending planned.
I’ll be real for a sec: I’m a very empathetic writer, so it’s tough for me to have my thoughts be overwhelmingly negative as Regimen’s universe demands. It was easier when I was unmedicated.
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technofinch · 1 month ago
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Okay guys real talk I was supposed to have an appointment with my psychiatrist on nov 5th but she never actually made the appointment or showed up and I haven't heard from or spoken to her since. Should I like. Send her an email
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jcsmicasereports · 2 months ago
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Primary dural-based parafalcine diffuse large b-cell lymphoma mimicking meningioma by Amr El Mohamad in Journal of Clinical Case Reports Medical Images and Health Sciences
Abstract
Background: Primary dural-based diffuse large B-cell lymphoma is very rare. Only few cases were reported in the literature. Case presentation: Herein, we present a case of an immunocompetent patient with primary dural-based diffuse large B-cell lymphomas mimicking meningioma associated with ghost tumor phenomenon without any evidence of a systemic lymphoma. Conclusion: Primary central nervous system lymphomas are rare. Clinicians should always consider this lesion as a differential diagnosis if radiological findings are not indicative of typical one meningiomas.
Key words: Dural-based tumor, diffuse large B-cell lymphoma, ghost tumor, MATRIX regimen, central nervous system.
Introduction
Primary central nervous system lymphomas (CNSLs) (PCNSLs) are rare and account for 2%–5% of all brain tumor cases, whereas secondary CNSLs are more common [1,2]. One study has shown that the most common intraparenchymal histological type is diffuse large B-cell lymphoma, as among 26 patients with PCNSL, 25 had diffuse large B-cell lymphoma [3]. Although primary dural-based lymphomas are rare, the most common area of involvement is the cerebral hemispheres. Most dural-based lymphomas are secondary and present as extra-nodal systemic diffuse large B-cell lymphomas. Primary dural-based lymphomas are usually histologically marginal-zone lymphomas, representing a group of lymphomas that have been historically classified together because they appear to arise from post-germinal center and marginal-zone B cells and share a similar immunophenotype, and few cases were reported to be diffuse large B lymphomas [4]. Here, we present a case of an immunocompetent patient with primary dural-based diffuse large B-cell lymphomas mimicking meningioma associated with ghost tumor phenomenon without any evidence of systemic disease.
Case Presentation
A 58-year-old male individual previously healthy and immunocompetent presented with headache, recurrent vomiting, and memory problems lasting for 3 days. No loss of consciousness, seizure, subjective weakness, or fever was observed. On physical examination, the patient’s Glasgow coma scale score was 15; his pupils were 3 mm in diameter, equal, and reactive; and the patient had nominal aphasia without motor and sensory deficit. He had normal cerebellar functions, and cranial nerve exams revealed no deficit. Head computed tomography (CT) (Fig. 1) showed a 2.2 × 3.8 cm (transverse × anteroposterior) iso-dense lesion with internal hypodensity in the left parasagittal frontal region extending to the right frontal region. Extensive perilesional edema was observed with effacement of the sulci and mass effect on bilateral frontal horns, associated with 3-mm midline shift. Head magnetic resonance imaging (MRI) showed an isointense parasagittal lesion on T1 and heterogeneous intense on T2, with redemonstration of perifocal edema (Fig. 2). Head T1-weighted imaging with contrast enhancement (Fig. 3) showed a large, left frontal, parafalcine, irregular-shaped mass located below the superior sagittal sinus level. It measured 4 × 3 × 3.3 cm in anteroposterior, mediolateral, and craniocaudal, respectively. It showed diffusion restriction (Fig. 4). There was central hyperintensity on T2-weighted imaging, without post-contrast enhancement area representing cyst formation. It exerts a mass effect characterized by effacement of the adjacent sulci, compression of the left lateral ventricle, and a 3-mm shift of the midline structures to the right side, and the impression of our neuroradiologist was atypical meningioma. Regarding extensive edema, dexamethasone was started at a dose of 4 mg, thrice a day, and the patient was planned for craniotomy and resection of the tumor. Initially, the patient was reluctant to undergo surgery; however, subsequently, the patient agreed to undergo surgery after approximately 10 days. During surgery, parasagittal craniotomy was performed; however, to our surprise, no definite mass lesion was found at the proposed site, in contrast to the findings described on imaging. The falx was thinned out and partly deficient. A biopsy sample was obtained from this abnormally appearing falx. Moreover, we obtained biopsy samples under neuronavigation guidance from abnormally appearing tissue, which was completely intra-axial, deep down in the lesion visualized on navigation. On postoperative day 1, MRI head with contrast enhancement (Fig. 5) showed that the previously seen lesion had a significant regression in size. Its right frontal extension and adjacent enhanced meningeal tail showed size reduction. Moreover, some regression in the perilesional vasogenic edema was observed. A significant regression in the previously described enhancement was noted at the left-side lentiform nucleus and external capsule. The MR spectroscopy study showed an increased choline/N-acetyl aspartate ratio and elevated lactate level within the lesion.
The histopathology results of the first brain biopsy samples (Figs.6–7) obtained from the falx cerebri showed meningothelial hyperplasia with calcification and focal perivascular lymphocytic infiltrate composed of small and large, atypical lymphocytes. Immunohistochemical staining was performed; however, the area of interest disappeared. The pathology team recommended another fresh biopsy to have the final diagnosis and flowmetry studies. So, the patient underwent redo craniotomy using the same incision, and multiple biopsy samples were taken. The second fresh brain biopsy (Figs. 8–9) showed multiple brain fragments with predominant perivascular atypical lymphoid infiltrates. Most cells were medium to large with moderate cytoplasm, atypical irregular nuclei having vesicular chromatin, variably prominent nucleoli, and several mitoses, including atypical one. Necrotic areas were also seen. Immunohistochemistry of the second biopsy (Fig.10 A-D) showed that atypical perivascular cells were positive for CD45, CD20, CD79a, BCl2, BCl6, MUM1, OCT2, and C-MYC, and negative for CD10, CD21, TDT, ALK1, EBV-LMP1, CD3, and CD5; however, few reactive/residual lymphocytes were positive for these enzymes. Moreover, 80% of lymphoid cellular nuclei were positive for Ki67. These findings were consistent with diffuse large B-cell lymphoma, not otherwise specified.
Whole-body positron emission tomography (PET) showed intense fluorodeoxyglucose (FDG) uptake higher than that in the healthy brain cortex, without evidence of coexisting systemic disease. In addition to PET scan, contrast-enhanced chest, abdomen, pelvis CT did not show any other lesions in the body; furthermore, workup for viral markers and autoimmune conditions were all unremarkable, thus confirming the diagnosis of “primary dural-based diffuse large B-cell lymphoma,” distinguishing it from secondary CNSL. The patient was transferred to the Oncology Department and started on three cycles of the methotrexate, cytarabine, thiotepa, and rituximab (MATRIX) protocol, which is the current standard treatment regimen for PCNSLs [5]. Three months after the diagnosis and after receiving two cycles of the MATRIX protocol, brain MRI with contrast enhancement (Fig. 11A, B) showed regression of the lesion, and PET scan showed complete metabolic resolution in terms of decreased FDG activity of the previously seen PCNSL without signs of lymphoma activity elsewhere. Subsequently, the patient received the third cycle of the MATRIX protocol without specific complications. Two weeks later, autologous stem cell transplantation (50 × 106/kg) was performed as part of the consolidation phase of treatment. Six weeks later, conditioning chemotherapy with carmustine–thiotepa was administered, followed by stem cell infusion (CD34 = 12 million/kg). The post-transplant course was complicated with mucositis, folliculitis, diarrhea, febrile neutropenia, and prolonged thrombocytopenia. Two months after transplantation, PET scan was repeated and showed complete metabolic resolution of initially seen PCNSL involvement. Currently, the patient is being followed by the hematology team; the patient is in good health and remission. The last outpatient follow-up was 8 months after the first surgery. The patient was seen by the vascular surgery (for permcath removal) and oncology teams. At this time, the patient was stable with complete remission; then, the patient was lost to follow-up. Another head MRI was performed and showed almost total regression of the lesion.
Discussion
Lymphomas in CNS are classified as primary, arising de novo from brain parenchyma, leptomeninges, eye, and spinal cord and as secondary to systemic lymphoma, which can be dural-based lesions. Secondary CNSLs are more common than PCNSLs. Most PCNSLs are intraparenchymal diffuse large B-cell lymphomas with a predilection to occur in the frontal lobe and then deep nucleic and periventricular locations; the infratentorial cerebellum is the most common location. However, primary dural-based lymphomas are rare, and even when found, they are histologically marginal-zone lymphomas. Few cases of primary dural-based diffuse large B-cell lymphoma have been reported in the literature [4,6]. Furthermore, PCNSLs are more common in immunocompromised patients with a mean age of 34 years, and they occur in immunocompetent individuals at an older age with a mean of 52 years [7]. The patient in this case report was 58 years old and immunocompetent without significant previous medical conditions. The latest review of the literature on primary dural-based lymphoma has been conducted by Quinn et al., who have found only 24 reported cases of primary dural-based diffuse large B-cell lymphoma, which confirms the rarity of the disease and subsequently the limited knowledge regarding this disease entity [8]. CNSLs have rapid response to steroids with shrinkage in size and initial remission [9]. Moreover, the initial response to steroids is associated with a better response to chemoradiotherapy and good prognosis [9]. In the patient in this case report, there was an unintentional delay of surgery for approximately 10 days, and the patient was on steroids (dexamethasone). In this case report, the failure to identify a discrete lesion of the size expected as perceived on initial imaging, despite proper surgical planning using neuronavigation, was probably due to the rapid regression of the tumor in response to steroids. This phenomenon agrees with the scientific literature reporting about the disappearance of lymphomas in response to steroids (ghost tumors) [10,11]. The pathogenesis of primary dural-based lymphoma remains unknown as there is no lymphoid tissue in the dura. It is hypothesized that it is related to chronic infection, autoimmune disease, or chronic inflammatory condition, which recruits polyclonal lymphocytes resulting in monoclonal lymphomas [6]. In contrast, the patient in this case report did not have any chronic conditions. All workups were negative, including the entire viral panel and autoimmune markers. Basic research is needed to determine the etiology of PCNSL, especially dural-based lymphomas. In the patient in this case report, the initial radiological findings were mimicking those of a meningioma: dural-based and uniformly enhanced. There was significant surrounding edema, significant diffusion restriction, and blooming in susceptibility-weighted image, which goes more with higher-grade meningioma or another high-grade lesion. One review has shown that primary dural-based lymphomas can display the “dural tail “sign, further confusing the preoperative diagnosis with meningioma [12], which did happen in the patient in this case report. Therefore, we suggest that in case of a dural-based lesion that has non-typical features of grade 1 meningioma, clinicians should consider lymphoma in the differential diagnosis and avoid steroids unless necessary due to edema and mass effect keeping in mind the ghost tumor phenomena of lymphoma.
The role of surgery in PCNSLs is limited mainly to histological diagnosis through biopsy or tumor debulking in case of increased intracranial pressure or impending brain herniation. Some studies have shown no benefit of complete surgical resection of PCNSLs; however, a recent systematic review of 244 articles has shown evidence in support of cytoreductive surgery [13]. Previously, whole-brain radiotherapy (WBRT) was the recommended treatment; however, this treatment modality resulted in a high rate of relapse and a decrease in performance status and cognitive impairment, and with the improvement in survival with high-dose methotrexate, WBRT is no longer recommended. Currently, newly diagnosed PCNSLs are initially treated with induction chemotherapy until complete radiological response, followed by consolidation therapy, to prolong the overall survival [14]. The International Extra Nodal Lymphoma Study Group-32 trial has shown that a methotrexate-based MATRIX regimen results in a good outcome and control rate in PCNSL [5], and it is the standard induction chemotherapy. Ferreri AJM, in his article “The role of autologous stem cell transplantation in PCNSL” has compared various consolidation phase treatment modalities, including beam radiation, carmustine–thiotepa regimens, and autologous stem cell transplantation, and the results showed that autologous stem cell transplantation resulted in good outcomes [15]. The patient in this case report showed a good response to treatment with almost total resolution of PCNSL with three cycles of MATRIX chemotherapy, followed by conditioning chemotherapy with stem cell infusion.
Conclusion
PCNSL is a rare entity. Clinicians should always consider it in differential diagnosis of meningioma if the radiological findings are not typical for meningioma. When there is a high index of suspicion of lymphoma, repeating neuroimaging, particularly MRI, before surgery, especially if the surgery is delayed while the patient is on steroids, may help develop a better management plan while dealing with this rare lesion. In case of lesion disappearance, falx biopsy can be an option. The aim of surgery in PCNSL is mainly biopsy or debulking to decrease intracranial pressure in case of significant mass effect.
List of abbreviation:
Primary central nervous system lymphomas (PCNSLs)
Central nervous system lymphomas (CNSLs)
Head computed tomography (CT)
magnetic resonance imaging (MRI)
positron emission tomography (PET)
fluorodeoxyglucose (FDG)
whole-brain radiotherapy (WBRT)
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taylortruther · 3 months ago
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I don’t wear makeup, but I do see a dermatologist about acne, and use mosturizer bc I don’t want wrinkles. Humans using paint and in other ways modifying their physical appearance goes back to the beginning of humanity. Obviously, the way that women are talked about and what the societal beauty expectations are for them is heavily misogynistic, but it’s also hard to know where the misogyny ends and the normal being humans begins
it's not a strict black and white answer, which is why questioning it frequently is so important (to me, anyway). one of my favorite questions to ask is how much of a choice is there? adorning your body, changing your appearance, isn't in itself misogynistic or limiting. but if a person wants to wear eyeliner or a skirt or keep their body hair, for example, what's the consequence? what's the consequence if they don't? if it's taboo, then that means our choices are limited, and maybe there's not really a choice at all.
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womanbellyblog · 7 months ago
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ajseoinfusions · 7 months ago
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smallboyonherbike · 11 months ago
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just got a youtube ad for egg donation and whenever that comes up i'm reminded of when i filled out the long ass online app for an agency and then they rejected my damn eggs bc i was honest about my family's health history....like i'm never having kids but then also this company is like "no one would want your shit genes" lmao
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billa-billa007 · 1 year ago
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Truffoire and Healthy Food Equals Perfect Skin
Healthy foods nourish skin from the inside, making it better apt at fighting environmental damage, stress and premature aging. On top of applying Truffoire skincare like White Truffle Day Cream and Black Truffle Instant Repair Syringe, that nourish your skin on the outside with beneficial blueberries, green tea, avocado oil and truffles, add these ingredients to your diet as well, to maximize the benefits. Invincibly healthy, radiant skin is the results of Truffoire skincare and healthy foods!
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honeytonedhottie · 8 months ago
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reset, refresh, move on⋆.ೃ࿔*:・🛍️
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GET UR NAILS DONE ;
sometimes when im feeling a bit stuck or if i feel that my energy seems clogged, getting my nails done makes me feel so put together and it helps my mental state too.
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getting my nails done makes me feel super feminine and it makes me feel put together. when i feel put together (even if im not) it acts like a push in the right direction.
CLEANING UR SPACE ;
a clean space = a clear mind. when our surroundings are cluttered, our minds are prone to be cluttered too and it can keep u stuck in a cycle that you feel stuck in.
wash ur sheets + pillow cases
pick up trash from ur room
put things where they belong
so force urself to get up and do some cleaning and i promise that you'll feel so much better afterwards and your mind will be a lot clearer.
RETAIL THERAPY ;
nothing screams "moving on" more then buying something nice for urself and treating urself to something that u want. for me, im a lipgloss junkie so i buy myself a new lipgloss.
HAIR AND BODY CARE ;
take an everything shower. use leave in products and make sure to be super meticulous and treat urself the way that u deserve. taking showers feels like hitting a refresh button so if u feel like ur in a funk, try and take a nice long shower.
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JOURNALLING SESSION ;
its important when u feel like u need to refresh to realign urself with ur goals and evaluate where you are now. so some journalling prompts for realignment are...
"have i moved forward, backwards, or stayed the same since my last entry"
"what can i do differently and what should i keep doing"
"have i been working towards my goals and if so how"
"have i been working towards my goals and if not how can i change that"
MAKE A RULE ;
to avoid getting in the habit of rotting away again, make a rule for urself. my rule is that i cannot spend two days in a row rotting. if i spend today rotting, tomorrow i need to get my act together.
make sure to know what works for u before u create and follow thru on a rule. having a rule provides some structure and semblance of "im going to get through this". like a safety net essentially.
everyone has periods in their lives when they feel lethargic or depressed so dont feel bad about urself if ur going thru that right now. it just matters that u get urself out of it when ur ready and u realign with what matters. love - honey
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