#Cancer Prevention Strategies

[elitereviwer]

What is cancer? How to prevent Cancer

“Understanding Cancer: Prevention, Insights, and Hope” Imagine a world where we could live without the fear of cancer looming over our heads, a world where stories of survival and prevention dominate the narrative. While we may not be there yet, we can certainly work towards it. In this article, we will embark on a journey to unravel the mysteries of cancer, empower you with knowledge, and share…

[brick-van-dyke]

While, yes, there is evidence of this being some of the case, I think it's important to also consider two important things: where the company who produced this source sit and how much of what's out there was propaganda for Russia or by others (and how this may somewhat overlap considering anti US government sentiment is something shared by both the Russian government AND US communists who are legit leftists).

So who owns WIRED? How reliable is it and how much weight should this article be given? The simple answer is, yes, it's all true, but also we have to be aware of the framing of this article and, most importantly, what is being omitted and what is being highlighted. There was absolutely interference in the 2016 election, this has also been proven in courts and in other sources beyond just the one given, so WIRED absolutely checks out with its facts as being true. However, not everyone who had this opinion was a Russian spy and certainly people who hated and still hate Hillary are Russian spies at all. However, many are leftists who are radical communists or anarchists who hold an agenda similar to that of Russia; the growth of communist ideologies and anti us government sentiment.

That reflects today and it's not only true for the US, but for Palestine as well. For those unfamiliar, Russia has been pushing (along with China) for a single state solution for Palestine and have been very aggressively anti Israel. This isn't because what Israel is doing is wrong though, this is because Israel is aligned with the USA and NATO, which is exactly what Russia's target was during election interference in the USA before and would be once again today. It's entirely to undermine the capitalist/ liberal USA government and always has been since even the Vietnam War and the Cold War.

What needs to be considered in this case is this then; is it an enemy of the capitalist system only or the existence of the USA at all? Would a new purely leftist government taken through revolution be Russia's goal, or the destruction of the government in order to win in a war? I actually don't know, but I do know that I can agree that democrats have committed horrific acts to keep NATO existing and that NATO itself is an imperialist power.

This is where a lot of nuance comes in here, do we accept that there is Russian propaganda that happens to align with leftist ideals or do we reject our own ideals because we don't want to confirm to Russian interference? It's hard to know what way is the "right" way since there is a lot of geopolitical factors at play here. It's hard to know what would be the overall best. Ultimately, I think it depends what type of future we, as individuals, want for the USA. If you're a Trotskyist, for example, you may align with Russia's perspective already since you already happen to believe in the same ideologies. Likewise, you may be against the fall of the government overall and want internal change through peaceful means and no use of force, which means voting blue anyway regardless of who it is even without this interference or knowledge of it. I think, in this way, as much as it is important to know all of this, it isn't as earth shattering as one might think at first glance. There's nuance and context behind it that, when you think about it, isn't all that surprising.

Essentially, it really depends on your beliefs and how ""susceptible"" to said propaganda you are. Especially since this propaganda isn't just "Russian propaganda" but specifically communist propaganda, which will push people into being radicalised into far left circles, which...isn't really a bad thing depending on where you sit. Of course, this isn't for everyone and those who are more centrist/ moderates would see it as a very bad thing for so much far left propaganda to exist and push for revolution. And overall, of course, both sides would have at least some concern that it's from a foreign country, no matter how inevitable it is due to the geopolitical context that said country would do this in any situation that could radicalise people into communism.

For people who don't remember the 2016 Tumblr was full of Russian trolls who posed as progressive social justice blogs and urged young liberals to throw their vote away on a third party. You can read more about it here :https://www.wired.com/story/tumblr-russia-trolls-propaganda/ This camapign was extraiordinary succesful and third party voters were a key reason why Trump one( if you look at the electoral results you will see that the race was so close that if the third party votes had gone to Hillary she would have easily buried Trump) Sadly we didn't know that this was a orchestred camapign until Tumblr released the data itself and told us who the blogs were. Those were not simple spam blogs. They were pros. They knew how to talk to people, they made real posts and interacted. They tried this in 2020 but we were wary because the memories were still fresh But now thy are trying again. I just found this guy who is running the EXACT same play book as in 2016. Pretending to be a person of color , poting progresive posts while at the same time urigng everyoe to vote third party. As soon as I called him out he immedately blocked me beause he knew I outed him. So now i's up to you guys. Don't let Trump supporting Russian trolls run their psy ops here. Report en masse and get them now instead of waiting for months for tumblr to tell us they worked for Trump REPORT THIS RUSSIAN TROLL NOW. DON'T LET THEM PULL THEIR GAMES AGAIN: https://www.tumblr.com/decolonize-the-left

[tvdfan23]

We had a rep for one of our skincare lines come in yesterday and tell us about some new products she wanted us to sell in the office and her behavior was so icky because she kept bringing up my freckles and the products I needed to get rid of them and I was just like 🙄

[reasonsforhope]

Article

"Every year, over 350,000 women die from cervical cancer and another 660,000 are diagnosed. [Note: Plus trans men and other trans people with a cervix.] As a consequence, children are orphaned, families impoverished and communities diminished by the loss of mothers, wives, daughters and sisters. 

And yet, unlike most other cancers, almost all these cases and deaths can be averted. We have powerful vaccines that can prevent infection with the human papillomavirus (HPV) that causes cervical cancer; we have diagnostics to detect it early; and we have treatments for those it strikes. With these tools, cervical cancer can not only be stopped; it could become the first cancer to be eliminated. Some high-income countries are already close to elimination, meaning fewer than four cases per 100,000 women.

But in many low- and middle-income countries, these tools are still not available, which is why 94% of cervical cancer deaths occur in those countries. 

In 2018, WHO launched a global call to action to eliminate cervical cancer, which was followed in 2020 by the adoption by all 194 WHO Member States of a Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem. The strategy calls for countries to achieve three targets by 2030: 90% of girls fully immunised against HPV; 70% of women receiving timely screening; and 90% of those found with precancer or cancer accessing treatment.

These targets are not just aspirational, they are achievable, even in low- and middle-income countries.  Bhutan has already reached the targets, the first to do so in the South-East Asia region. 

Since introducing the HPV vaccine in 2011, Rwanda has reached vaccine coverage of 90%, and today announced its national goal to reach the 90-70-90 targets three years ahead of schedule, by 2027. Already, in two districts – Gicumbi and Karongi – Rwanda is meeting those goals. Nigeria, which introduced the HPV vaccine in October last year [2023], has already vaccinated 12.3 million girls.  

We have the tools and the opportunity to eliminate cervical cancer. 

Since WHO issued the global call to action in 2018, more than 60 countries have introduced the HPV vaccine into their immunisation programmes, bringing the total to 144 countries that are routinely protecting girls from cervical cancer in later life. With scientific advances, we can now prevent cervical cancer with just a single dose, which 60 countries are now doing.  

The largest provider of HPV vaccines to low- and middle-income countries is Gavi, the Vaccine Alliance, which plans to vaccinate 120 million children between now and 2030. But this plan requires that investments in health are sustained. We are also counting on manufacturers to confirm and honour their commitments to provide HPV vaccines to low- and middle-income countries in the coming years, to avoid the supply constraints that held back progress in the past.

But we cannot rely on vaccines alone. The impact of the rapid scale-up in vaccinating girls now will not be seen for decades, when they reach the adult years when cervical cancer typically appears. To save lives now, we must match the increase  in vaccination with increases in screening and treatment. 

Decades ago, as more women gained access to pap smears in developed countries, the mortality associated with cervical cancer dropped rapidly. Today, even better tests are available. Over 60 countries now include high-performance HPV tests as part of their screening programs. Women can even collect their own samples for HPV testing, removing more barriers to life-saving services. In Australia – which is on track to become one of the first countries in the world to achieve elimination – more than a quarter of all screening tests are now done this way...

Several countries are also investigating the use of artificial intelligence to enhance the accuracy of screening in resource-limited settings. When women are found with precancerous lesions, many are now treated with portable battery-powered devices, which can be operated in remote locations."

-via The Telegraph, November 18, 2024. Article written by Dr Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO).

[ezrazone]

incredible updates regarding mohamed al manasra's campaign:

mohamed's gofundme page is finally back online after weeks of a technicality preventing him from initiating transfers! please donate and share as widely as possible! family and friend group chats, phone calls, and emails are some of the best ways to get eyes on this campaign!

another update: mohamed's wife, manal, now has an ally at al-shifa hospital who is willing to vouch for her at the border crossing so that she can get into egypt for proper cancer treatment. this is miraculous news, and hugely increases chances of survival for the entire family. manal's friend at al-shifa predicts that he will be able to move manal out of gaza within a month (around the 2025 new year). it is now more important than ever that mohamed's campaign circulate as far as possible. we need these donations to make sure mohamed, manal, and all three of their children can make it past the rafah crossing. the stars have aligned for this family, and it is now our job to get them the funds they need to escape the gaza strip. here are alternative app links that go directly to mohamed's fundraiser organizer. we believe that a diversity of platform options is our smartest strategy going forward, so mohamed may still collect donations when one platform stalls or fails:

cashapp link (for americans)

venmo link (for americans - please do not indicate anything having to do with palestine in description)

paypal link (note: people have been having issues with this link and it’s not clear if it’s just a general issue with paypal or not. i’m leaving it up for now but thankfully the GFM is working again anyway)

mohamed’s fundraiser is vetted #192 here! please help my dear friend. god bless you who are generous and brave for this family that i love so much.

tagging for reach: @transmutationisms @anneemay @determinate-negation @shivroy @teethburied @schoolhater

[sizzlingsandwichperfection-blog]

Hi. I've started writing a semi-weekly TB Newsletter, if you're interested in that kind of thing. Here's the second letter--about public-private partnerships, leprosy, and my forthcoming big announcement about expanding access to tuberculosis care. You'll hear more about that on Thursday. Anyway, here's the newsletter. You can sign up here.

---

In advance of the Big Announcement this Thursday, I made a vlogbrothers video today on how we end TB–with the comprehensive care plan often known as S-T-P, which is short for “Search, Treat, and Prevent.” But one thing I didn’t discuss in that video is the downstream benefits of comprehensive TB care.

Once you’ve hired community health workers to screen for TB, it becomes much easier to screen for other illnesses like diabetes, high blood pressure, and non-TB lung issues (especially lung cancer). TB is notoriously a disease of vicious cycles–a disease of malnutrition that makes malnutrition worse, a disease of poverty that makes poverty worse, and so on–but addressing TB can be a story of virtuous cycles: TB survivors become TB advocates, as I’ve seen with my friend Henry in Sierra Leone. More effective TB treatment leads to less stigmatization of the disease, as communities come to see the disease as curable and survivable rather than terrifying and deadly. And better access to TB care leads to a stronger overall healthcare system, because more community health workers are better connected to more primary healthcare clinics, which allows communities to better address all kinds of health problems.

—

Mycobacterium tuberculosis is not the only bacteria of its family that causes a lot of human suffering; there is a closely related species called mycobacterium leprae that causes the disease known as Hansen's Disease, or more commonly leprosy. There are still around 200,000 cases of leprosy diagnosed each year around the world, and while the disease is curable, it also remains–especially if not caught and treated early–a significant driver of suffering and disability in our world. 

There are many connections between TB and leprosy: Not only are the bacteria that cause these illnesses very similar, but patients have often expressed similarities in experience. TB patients who were encouraged or forced to live in sanitariums often compared themselves to lepers. One disheartening parallel between the diseases is that in both cases, those living with these illnesses are often abandoned by their families and must make new social connections within the new community of “leper” or “consumptive.” Also, both Hansen’s Disease and TB continue to exist largely because of systemic failures rather than due to a lack of knowledge or technology.

—

I really recommend Dr. Salmaan Keshavjee’s TED talk about how we ended TB in the U.S., and how we can end it using the same strategy around the world.

—

Last link from me today: I’ve been thinking a lot about the complex intersection between public and private investment (for reasons that will be clear on Thursday!) and I keep coming back to one infographic in an excellent paper (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256883) about the public money that was poured into the creation of the GeneXpert Machine, which can quickly and accurately test for TB. The GeneXpert machine has created a lot of profit for Danaher’s shareholders, and it has also created some societal benefit, but it could create a lot more societal benefit if it created less profit for Danaher’s shareholders. This tension seems to me one of the defining features of 21st century life. Anyway, here is the infographic:

That’s the money–over $250,000,000 of it–that came from taxpayers (mostly in the U.S. and Europe) to fund the creation of the GeneXpert Machine. And yet, this tech largely funded by the public is controlled entirely by private enterprise. I’m troubled by that model of value allocation, even if I still believe that private money and private enterprise have important roles to play in fueling innovation. But taking a quarter billion dollars of public money and then claiming total ownership over a technology, and using that ownership to deny the technology to the world’s poorest people, seems like a deeply flawed system of resource distribution to me.

I’ll see you on Thursday. I’m nervous and excited.

DFTBA,

John

[izooks]

Some of Joe Biden’s accomplishments:

**Domestic policy**

* **American Rescue Plan (2021)**: Provided $1.9 trillion in COVID-19 relief, including direct payments, enhanced unemployment benefits, and funding for vaccines and testing.

* **Infrastructure Investment and Jobs Act (2021)**: Allocated $1.2 trillion for infrastructure projects, including roads, bridges, broadband, and clean energy initiatives.

* **Bipartisan Safer Communities Act (2022)**: Expanded background checks for gun purchases and provided funding for mental health services.

* **Child Tax Credit Expansion (2021-2022)**: Temporarily expanded the Child Tax Credit to provide up to $3,600 per child in monthly payments.

* **Affordable Care Act Expansion (2021)**: Made health insurance more affordable for low- and middle-income Americans by reducing premiums and expanding subsidies.

**Foreign Policy**

* **Withdrawal from Afghanistan (2021)**: Ended the 20-year war in Afghanistan.

* **Re-joining the Paris Agreement (2021)**: Re-committed the United States to global efforts to address climate change.

* **Strengthening Alliances with NATO and the EU (2021-present)**: Repaired relationships with key European allies after strained relations during the Trump administration.

* **Supporting Ukraine in the Ukraine-Russia War (2022-present)**: Provided military, humanitarian, and diplomatic support to Ukraine in its defense against Russia's invasion.

* **Nuclear Deal with Iran (2023)**: Revived negotiations with Iran on a comprehensive nuclear deal, aimed at preventing Iran from developing nuclear weapons.

**Other Notable Accomplishments**

* **Appointing Ketanji Brown Jackson to the Supreme Court (2022)**: Made history by being the first Black woman appointed to the nation's highest court.

* **Signing the Respect for Marriage Act (2022)**: Ensured federal recognition of same-sex and interracial marriages.

* **Establishing the Office of the National Cyber Director (2021)**: Coordinated federal efforts to combat cybersecurity threats.

* **Creating the COVID-19 National Preparedness Plan (2021)**: Developed a comprehensive strategy to respond to future pandemics.

* **Launching the Cancer Moonshot (2022)**: Re-energized the government's efforts to find a cure for cancer.

[dragonagitator]

House MD fans: You wake up in the PPTH ER in summer 2004. What you doing?

Scenario parameters:

All your memories of the show and the past 20 years are intact.

You are stuck there/then and cannot return to our universe/year.

You have nothing but the hospital gown on your back.

Questions:

So, what do you do?

How much would you tell House?

How would you get him to believe you?

Who else would you tell?

How much would you tell them?

Inspiration:

The author self-insert isekai fanfic "Intervention" by VivatRex (aka @acrownforaking). They've been writing it for the past 11+ years and are still updating. It's already nearly 300k words long despite only being up to the events of S02E15. I AM IN AWE.

I haven't been able to stop thinking about this scenario ever since I read that fanfic a month ago. I'd love to discuss it with other House MD fans and hear what you would do.

(Apologies to the mutuals for the abrupt blog topic change. A new brainrot has taken hold.)

My short answer:

My long answers are below the cut.

So, what do you do?

My primary objective would be to enlist House in averting the pandemic.

My reasoning: If anyone can nip it in the bud before it gets out of Wuhan, I figure that a world-renowned genius doctor who is an infectious diseases specialist, speaks Mandarin, and now has a 15-year head start would have the best chance.

Difficulty level: Babysitting a narcissistic manchild with the self-preservation instincts of a toddler until the year 2020 so that he makes it there then alive, out of prison, and with his sanity, medical license, and professional reputation intact. To quote Quantum Leap, "Ohhhhhh boooooooy."

Strategy: I'm in the "I could fix him, but whatever's wrong with him is way funnier" camp, so I wouldn't try to change him (that always backfires anyway). Instead, I'd try to change his circumstances:

A stable romantic relationship would help, so I'd seduce him if I can (I'm not his type but a gal's gotta shoot her shot), try to get him together with Dominika earlier if I can't, and tell him how horribly his relationship with Cuddy ended so he knows better than to even start it.

Avert the shooting. Moriaty was a patient so his info is in the PPTH files. I AM THE ONE WHO KNOCKS. Or for a less murdery approach, try to get him arrested in April 2006 for violating New Jersey's strict gun laws.

Warn House about Tritter so he can switch patients with another clinic doctor.

Warn House to never get on a bus with Amber.

Tell Kutner I'm from the future and he's the only one who can prevent something horrible from happening (he's a Trekkie so he'll want to believe), then unfurl my big timeline poster and point at the "Kutner suicide early 2009" stickynote and ask him "so what's up with that, dude?"

Tell Wilson everything I can remember about his cancer -- he's an oncologist and thus can work backwards from there to figure out when to start checking for it so he can cut the tumor out while it's still just a tiny baby.

I would take a harm reduction approach to House's drug use, e.g., suggest that he try microdosing psilocybin and extend his liver's lifespan by substituting cannabis for some of his Vicodin and alcohol consumption.

Methods: Even though he doesn't have one for most of the show, House mentions a few times that he's entitled to hire an assistant, and I happen to be excellent at administrative work.

I think he'd be willing to hire me because working as his executive assistant / department secretary would position me to recognize patients as they come in so that I can discreetly pass along anything I remember, e.g., the kindergarten teacher has pork worms in her brain, ask the scientist in Antarctica to show you her feet, etc.

Meanwhile, I could lurk around the hospital preventing miscellaneous shit, e.g., get the gift shop volunteer from S01E04 to go home sick, ensure that the gunman from S05E09 is promptly admitted, diagnosed, and treated before he snaps and takes hostages, etc.

Possible sidequests:

Use my foreknowlege to get rich by milking online poker bonuses until the passage of the UIGEA in 2006, use my poker money to start flipping houses until 2007, get in on the "Big Short" in 2008, and set a Google Alert for "Bitcoin" so I can start mining/buying it from day one. Unfortunately, I haven't paid enough attention to individual stocks to play the market other than knowing that Amazon would be a good long-term buy & hold.

Use my riches to change the outcome of the 2016 election and try to steer the development of the internet and society in general in a slightly less stupid direction.

Send Pete Carroll a letter postdated just before the 2013 Superbowl telling him the outcome, then suggest for the final play of the 2014 Superbowl that the Seahawks try handing the ball off to Marshawn Lynch instead of throwing it because that throw will be intercepted. PRIORITIES.

How much would you tell House? How would you get him to believe you?

Your story about being from the future of an alternate universe in which House and everyone he knows are characters on a fictional TV show is already too batshit crazy to believe even without his kneejerk "everybody lies" skepticism. How would you differentiate yourself from all the patients who pull crazy stunts to try to get him to take their case?

My answer: For the "from the future" part, I'm hoping there's some sort of test that House could run to confirm that I was indeed vaccinated with a mRNA vaccine against the COVID-19/SARS-COV-2 virus. Given that neither of those things existed in 2004, that would be physical evidence that I'm not from around here now.

If producing physical evidence isn't possible, then I know that Vegetative State Guy from S03E15 is already a patient at PPTH because he'd been there for 10 years, so I'd find him and tell House about his son. I could also tell House enough about the cases from the first few episodes that I'm pretty sure he'd believe me by Christmas. I want in on Chinese food with Wilson.

I would wait until House accepted the "from the future" part before broaching the "fictional TV show" issue. Until then, "I watched a TV show about your life and cases" is a 100% true statement and it's not my fault if he assumes that show was a documentary. :)

Once he believed me, I'd tell him everything.

Who else would you tell? How much would you tell them?

There are people out there who would literally kill for your knowledge of the future, so going public or being too open about it seems highly risky.

My answer: I'd tell House, Wilson, and Chase right away. Kutner but not before Jan 2009. Maybe eventually Cuddy and the rest of the Diagnostics team if keeping my foreknowledge of the future from them proves too difficult.

House is the only one who gets to know everything. Everyone else is on a "need to know" basis.

I might also bring Bill Arnello (the brother/lawyer of the mob informant in S01E15 "Mob Rules") into the circle of trust because he could be a very useful resource for some of my sidequests, e.g., changing the outcome of the 2016 election far far far in advance and in the most direct way possible. (Hi, Secret Service! This is a purely hypothetical discussion about time travel and not at all indicative of any real criminal intent, pls do not pay me a visit, kthxbai.)

I think the only people I would tell the "fictional TV show" part to would be House, Wilson, and Chase, because there are things I need to warn them about that definitely wouldn't have been in a documentary. Like Chase needs to know that killing Diballa is 100% the right thing to do but he seriously needs to work on his OpSec. Everyone else gets the implied documentary lie of omission.

If I get caught knowing too much by random patients, I'll just claim to be psychic. Way more people believe in that than would believe in time travel.

What would you do?

[covid-safer-hotties]

Also preserved on our archive

By Robert Pearl, M.D.

In the late 1970s and early ‘80s, a mysterious illness spread through America’s overlooked communities, mainly affecting intravenous drug users and homosexual men.

The disease, which caused a sudden and devastating collapse of the immune system, was unlike anything doctors had seen before. Patients arrived at hospitals with rare infections like Kaposi’s sarcoma and fungal pneumonia.

But despite the rising number of cases, public health officials remained silent for years. Few Americans saw it as a national emergency, especially since the disease seemed confined to society’s fringes, at least initially.

By the time the government and public fully grasped the threat in 1986—following Dr. C. Everett Koop’s “Surgeon General’s Report on AIDS”—tens of thousands of Americans had already died.

Looking back on this and other public health crises, it’s clear that medical science alone isn’t enough to save lives. To prevent similar tragedies, public health leaders and elected officials must first understand the role denial plays in people’s perception of medical threats. They must then develop effective strategies to overcome it.

The Psychological Basis For Denial Denial is a powerful, usually unconscious defense mechanism that shields individuals from uncomfortable or distressing realities. By repressing objective facts or experiences—especially those that provoke fear or anxiety—people can maintain a sense of stability in the face of overwhelming threats.

Historically, denial was vital to daily life. With little protection against illnesses like smallpox, tuberculosis or plague, people would have been immobilized by fear if not for the ability to repress reality. Denial, mixed with superstition, took the place of facts, allowing society to function despite the ever-present risks of death and disability.

Today, even with tremendous advances in medical knowledge and technology, denial continues to influence individual behavior with detrimental consequences.

For example, more than 46 million Americans use tobacco products, despite their links to cancer, heart disease and respiratory illness. Similarly, tens of millions of people refuse vaccinations, disregarding scientific consensus and exposing themselves—and their communities—to preventable diseases. Denial extends to cancer screenings, as well. Surveys show that 50% of women over 40 skip their annual mammograms, and 23% have never had one. Meanwhile, about 30% of adults between 50 and 75 are not up to date on colorectal cancer screenings, and 20% have never been screened.

These examples demonstrate how denial leads individuals to make choices that jeopardize their health, even when life-saving interventions are readily available.

A Pattern of Denial: How Inaction Fuels Public Health Crises When individual denial scales up to the collective level, it fuels widespread inaction and worsens public health crises. Throughout modern medical history, Americans have repeatedly underestimated or dismissed emerging health threats until the consequences became impossible to ignore.

Early warnings of the HIV/AIDS epidemic were largely ignored, as the stigma surrounding affected populations made it easier for the broader public to deny the severity of the crisis. Even within at-risk populations, the lengthy delay between infection and symptoms created a false sense of security, leading to risky behaviors. This collective denial allowed the virus to spread unchecked, resulting in millions of deaths worldwide and a public health challenge that persists in the United States today.

Even now, four decades after the virus was identified, only 36% of the 1.2 million Americans at high risk for HIV take PrEP (Pre-Exposure Prophylaxis), a medication that is 99% effective in preventing the disease.

Chronic diseases like hypertension and diabetes mirror this pattern of denial. The long gap between early signs and life-threatening complications—such as heart attack, stroke and kidney failure—leads people to underestimate the risks and neglect preventive care. This inaction increases morbidity, mortality and healthcare costs.

Whether the issue is an infectious disease or a chronic illness, denial causes harm. It allows medical problems to take root, it delays care and it leads to tens of thousands preventable deaths each year.

The Unseen Parallels: COVID-19 And Mpox Our nation’s responses to COVID-19 and mpox (formerly known as monkeypox) similarly illustrate how denial hampers effective management of public health emergencies.

By March 2020, as COVID-19 began to spread, millions of Americans dismissed it as just another winter virus, no worse than the flu. Even as deaths rose exponentially, elected officials and much of the public failed to recognize the growing threat. Critical containment measures—such as travel restrictions, widespread testing and social distancing—were delayed. This collective denial, fueled by misinformation and political ideology, allowed the virus to take root across the country.

By the time the severity of the pandemic was undeniable, hospitals and health systems were overwhelmed. The opportunity to prevent widespread devastation had passed. More than 1 million American lives were lost, and the economic and social consequences continue today.

Mpox presents the most recent example of this troubling pattern. On August 14, the World Health Organization declared mpox a global health emergency after identifying rapid spread of the Clade 1b variant across several African nations. This strain is significantly more lethal than previous variants, having already caused over 500 deaths in the Democratic Republic of Congo, primarily among women and children under 15. Unlike earlier outbreaks associated mainly with same-sex transmission, Clade 1b spreads through both heterosexual contact and close family interactions, increasing its reach and putting everyone at risk.

Despite these alarming developments, awareness and concern about mpox remains low in the United States. International aid has been limited, and vaccination efforts have fallen far behind the growing threat. As a result, by the time the WHO issued its emergency declaration, only 65,000 vaccine doses had been distributed across Africa, where more than 10 million people are at risk. Already, cases have appeared in Sweden and Thailand, and the U.S. may soon follow.

Even with the added danger of the new variant and the proven efficacy of the JYNNEOS vaccine, only one in four high-risk individuals in the United States has been vaccinated against mpox. Our slow and delayed response to Covid-19, mpox, HIV/AIDS and nearly-all chronic diseases demonstrate how widespread denial is, the lives it continues to claim and the urgent need to address this hidden defense mechanism. The best way to overcome denial—both individually and collectively—is to bring the risks into clear focus. Simply warning people about the dangers isn’t enough. Strong leadership is crucial in breaking through this subconscious barrier.

Lessons To Learn, Actions To Take Dr. C. Everett Koop’s public health campaign on AIDS in the 1980s demonstrated how clear, consistent messaging can shift public perception and drive action. Similarly, former Surgeon General Luther L. Terry’s landmark 1964 report on smoking educated the public about the dangers of tobacco. His report spurred subsequent efforts, including higher taxes on tobacco products, restrictions on smoking in public places and health campaigns using vivid imagery of blackened lungs—leading to a significant decline in smoking rates.

Unfortunately, government agencies often fall short, hampered by bureaucratic delays and overly cautious communications.

Officials tend to wait until all details are certain, avoid acknowledging uncertainties, and seek consensus among committee members before recommending actions. Instead of being transparent, they focus on delivering the least risky advice for their agencies. People, in turn, distrust and fail to heed the recommendations.

Early in the COVID-19 pandemic, and more recently with mpox, officials hesitated to admit how little they knew about the emerging crises. Their reluctance further eroded public trust in government agencies. In reality, people are more capable of handling the truth than they’re often given credit for. When they have access to all the facts, they usually make the right decisions for themselves and their families. Ironically, if public health officials focused on educating people about the risks and benefits of different options—rather than issuing directives—more people would listen and more lives would be saved.

With viral threats increasing and chronic diseases on the rise, now is the time for public health leaders and elected officials to change tactics. Americans want and deserve the facts: what scientists know, what remains unclear and the best estimates of actual risk.

[smaller-comfort]

So how do you imagine snail love darts and necrontyr working/combining? Cause I am interested~

Aksjdhsk ahahaha oh god okay here we go

(Tumblr crashed on me three times while I tried to write this, but I will not let that stop me from rambling at length about snail sex, speculative xenobiology, and various ways that necrontyr get to be fucked up little guys.)

Okay. Some assumptions/general thoughts: necrontyr do not have "dual-use" reproductive/waste elimination systems (inferred from Trazyn's hilarious disgust at the idea, but honestly it would be entirely believable for him to have completely lost any and all memories of necrontyr biology). A lot of higher order animals do (they're efficient!), but you start to see ones that don't when you get down to bugs and marine creatures, so that's what kicked off this train of thought.

I'm assuming also there is relatively little sexual dimorphism among necrontyr (not for any particular reason, although my understanding is that actual female necrons are a relatively new thing in wh40k lore, so that fits). And finally, everyone constantly dying of turbo cancer has led to a 'throw everything but the kitchen sink at it' evolutionary approach to reproductive strategies.

Okay, now snails: they use the darts during courtship to deliver hormones that increase the likelihood of fertilizing their partner's eggs; after the several-hours-long mating dance, they'll exchange spermatophores. (Fun fact, the penis, copulatory canal, and dart sac are all located inside the genital pore, on the snail's head. Mating dances can involve a lot of biting.) Snails have bad aim, but it's not uncommon for both snails to end up getting stabbed during courtship.

"Copulatory canal" is a deeply unsexy phrase, btw. So are most words we use when talking about sex, unfortunately. *sigh*

Anyway. While many necrontyr do only have one set of functional reproductive organs by the time they reach adulthood (either because the other set was always vestigial or because it gets removed to reduce the spread of cancer), both sets are usually present in some fashion. Sterility would be fairly common, but medical technology is able to mitigate some of that; the lower classes, at least, need to be able to breed like rabbits to feed the war machine. Gender is mostly divorced from reproductive role by the time biotransference happens; in addition to male and female, there would have been at least one other normative gender, possibly two (to account for both null and multimodal genders). Gender fluidity would have been common and largely unremarkable for necrontyr. (It's still largely unremarkable for necrons, but it's not particularly common; they're mostly fixed with whatever gender they had at biotransference.)

Okay, so, love darts. Pretty much only ever used by nobles/the military, because in the upper classes of society, sex isn't about reproduction, it's about reinforcing social hierarchies. And necrontyr social hierarchies tend to be inherently about violence in one way or another. Sexual dominance is generally more about who gets stabbed with the dart than it is about which penis is going where. (That's still a factor, but it's secondary, since genital configurations/functionality can be a bit of a wildcard.) Snails take an egalitarian approach to sex; necrontyr categorically do not. Both parties consenting to be darted would be considered weird and perverted.

Kind of going off ancient greek/roman sexual mores here; it would be entirely unthinkable, for example, for Obyron to be the penetrative partner in either sense with Zahndrekh. (Then again, Zahndrekh is a shameless pervert.) Sex between two social equals is generally accompanied by an agreement- sometimes tacit, sometimes explicit- about not using the darts. Doing so would be an overt act of aggression. Often, to prevent any potential misunderstandings, they'll voluntarily empty their dart sacs ahead of time.

Forcing someone to empty their dart sac prior to sex is a pretty common form of sexual humiliation. When done voluntarily, it's a sign of submission or respect. (Darts usually have a refractory period of a few days, depending on the person's overall health. Single-chambered dart sacs are typical, but multiples aren't unheard of. Leads to occasional 'surprise! You thought I was submitting to you but now you're getting fucked instead' situations.)

The dart sac would be located in their mouths, under the tongue; it's meant to be ejected into the soft tissue of the mouth, but it's sharp enough to pierce the skin anywhere. (This does mean kissing can be Complicated, or at least somewhat subversive, depending on everyone's social standing.) Normally it gets broken down and absorbed by the recipient's body; pulling one out tends to be extremely uncomfortable/painful.

The exact cocktail of hormones and neurochemicals it injects the other person with would vary somewhat between individuals, but can potentially vary widely between dynasties or social classes due to genetic/geographic/cultural differences. Some might include a mild paralytic agent; some sort of euphoric effect is also common. (This is all in addition to the original function, which, uh. Is to make the recipient more likely to get pregnant.) The shape of the dart varies in a similar fashion, ranging from a straight, smooth bone spike to something more elaborate with barbs or fluting.

(A bloody mouth can signify a lot of things to necrontyr- in addition to violence or illness, it's also inherently erotic. Necrons who remember this try very, very hard not to think about it when confronted with Flayed Ones.)

(Yenekh: *very sexily smearing his mouth with blood and draping himself all over Oltyx*

Oltyx: *oblivious, can't stop thinking about how pretty Yenekh is*

The rest of the flayed ones: *still not sure why their king and his consort haven't fucked nasty in a pile of carrion yet. Maybe they need a bigger pile of carrion? Yes, that's probably it. They will take care of this for their beloved king.*)

Crypteks have their own social hierarchies within their conclaves, but they're usually not as concerned with sexual politics as nobles and the military tend to be. Most people believe that crypteks all lace their love darts with poison, and the crypteks don't try to discourage that assumption. Some of them probably do, tbh.

Necrons, of course, don't have genitalia, but they can still stab each other with love dart analogues- this ranges from things like executive buffer override packages sent via interstitial channel, to actually physically jamming a spike of necrodermis into a neural input node. (From a purely aesthetic/romantic standpoint I also like the idea of love darts constructed out of crystallized core flux. The first time Zahndrekh does that to Obyron he goes into complete cascade failure and takes several hours to reboot.)

If Orikan and Trazyn did have sex pre-biotransference, one of them would have darted the other without permission (probably accidentally, being that they are both intensely nerdy losers and thus Bad At Sex by necrontyr standards), setting off a sixty-five million year hate-sex feud that neither of them can even remember the origin of. Orikan would've gone after Trazyn's mouth with a pair of pliers at some point; joke's on him, Trazyn's into that.

(Trazyn does have a collection of necrontyr love darts in the archives- all of them ones he collected personally when he was alive. He has no absolutely no memory of slutting it up back in the day, though, and probably doesn't even realize what they are. Sannet, unfortunately, does remember, and wishes he didn't. He has had to put up with so, so much over the years.)

[mindblowingscience]

The silica nanoparticle can be loaded with temozolomide, a small molecule drug used to treat glioblastoma brain tumors, the researchers say.

“This chemotherapy drug has limitations—it t doesn’t stay in the blood for very long, it can be pushed out of the brain, and it doesn’t have high penetration from blood into the brain,” says Taskeen Janjua, from the School of Pharmacy at the University of Queensland.

“To make the drug more effective, we developed an ultra-small, large pore nanoparticle to help it move through the blood-brain barrier and penetrate the tumor while also reducing unwanted patient side effects.

“This strategy could be a more effective way to treat brain cancer and prevent it from coming back,” Janjua says.

Continue Reading

[oldguardleatherdog]

"How now shall we live?"

First steps towards an effective resistance.

What was good and true and right the day before the election remains good and true and right today, and no mass delusion or wrong choice by a misguided and ill-informed majority changes that truth.

A revival of the Resistance movement is starting to stir online and in the real world; resolve is beginning to coalesce among people of goodwill. I would favor an approach designed to prevent the POS from taking office at all, but since Kamala's come out in favor of a boring old peaceful transition (dang it!), a different strategy is called for.

The best ideas I've seen are variations on finding ways to thwart the POS and his gang of idiots at every turn using every tool we have available to us, and I think that’s going to be our way forward.

But for us to have a chance at effective resistance at scale, resolve and energy and a united effort on the LGBTQ+ side and other parts of our “coalition of the good” will be required in abundance to sustain long-term resistance and disruption of the plans and actions of this Administration that are clearly designed to injure and harm us in a multitude of ways; many of us have been put on notice that we’re targets, and the level of fear and uncertainty of our safety is off the charts – something America has not had to contend with in hundreds of years.

What could an effective, robust, muscular resistance look like in our current moment? Well, I have thoughts. Stay with me here, I have specifics to lay out for you, but there are some words to climb - beautiful words, all the best words, strong men with tears in their eyes come to me and say - (continued after the jump)

It begins with individual resolve, and continues by engaging with others. This is not the time to isolate, to stay solo: we need to connect. No self-lockdowns or heads in the sand or hiding under the covers!

It's not important to have a fully fleshed-out game plan at this point. It's important that we view things as they are and discern the next right thing to do. We need to make sure that we walk in the light, that we stay aligned with what we know is right. If we allow darkness or corrupt motives into what we do, we will fail. (This is getting slightly on the woo-woo side of things, but I view it as fundamental to our success.)

Light is a funny thing: it dispels darkness, it provides safety, it guides us through rough waters and difficult pathways, but in concentrated form it can be a laser that slices someone's arm off, and it can give you skin cancer if you're outdoors without sunscreen.

Lucifer, after all, is the Angel of Light, as his name in Latin will tell you - and this activist and spiritual warrior of four decades will tell you that each step we take needs to be effective, morally justifiable, and targeted so that collateral damage is minimized. MAGAs bludgeon with indiscriminate blunderbusses and misshapen cudgels; we wield stilettos, trip wires, keenly aimed photon grenades into unprotected garbage vents.

I am convinced that we will endure, survive, even thrive, and in the end prevail.

This will be the most difficult effort of our lives to date, individually and collectively, and the stakes could not be higher.

We do not yet know the shape and form of the perils in store. What is already apparent, though, is the wanton cruelty and brazen sadism of our enemies now unfurled at full mast, as the vile stench of the devious, depraved methods they’re devising to inflict maximum misery wafts towards us.

They have not been shy or coy in communicating their plans and intentions, and they’ve been gleefully bragging about the methods, implements, tools, and techniques they intend to employ to bring their dark and nihilistic vision into reality.

They are, almost literally, and with the full-throated exhortations of their Christian Nationalist religious auxiliaries and avatars and “prophets,” bringing Armageddon from the fever dreams of St. John out of antiquity and into our real world. For the first time since September 11th, humanity will encounter pure unadulterated evil in ways we can see, hear, feel, taste, smell, made corporeal, physical, inescapable, and we will have to contend with it face to face.

Right now, I'm not advocating leaving the country, but our trans friends in particular will need to have resources and safe pathways to move to sanctuary cities and states. We need to throw our support behind organizations that can effectively and responsibly move people out of danger, and if those orgs don't exist, we need to create them.

I'd intended to retire from activism post-election, but I've changed my plans. I'm here for the long haul.

We are not fools. We know what we see. We know the difference between right and wrong, good and evil, what destroys and what uplifts.

And when we behave accordingly, with smarts and courage and clarity of intent and spirit, we can from time to time do some real good in this world.

Of course, progress comes in fits and starts, and this is a scary time no matter how grown-up we are, but we've got to be brave enough to live and to fight for what’s right, even when all we can see is darkness.

Remember, you are not alone, and we are finding ways to support you when you reach out.

~~~

All these words, Animal, I hear you saying. All these lofty thoughts, all this cheerleading, and you haven’t given us one damn thing to do about this. Do you actually have a plan? Or even a concept of a plan?

Well…the first thing to do is engage.

Staying solo won't help. Human contact is key right now, for the cause, and for our own spirits. Do not isolate.

There are already gatherings and organizations ramping up and calls for zoom meetups and in-person actions. Monitor your socials, keep your eyes and ears open, and you will find a place or places where your help will be uniquely well fitted.

Look at your communities, the people and places that make up the fabric of your daily life and walk, and you will find many dynamic and determined people from all backgrounds and age groups who are ready to do something now.

You may want to consider starting something yourself, first as a mutual encouragement effort among friends, and then as the weeks go by and you see what's coming down the pike, develop counter-actions with the group you've got. Feel free to reach out to me for ideas and advice and encouragement and shoulder to cry on and everything and anything you can imagine. I'm not going anywhere.

~~~

I’ve been thinking about a time many years ago, when I was a young hotheaded activist in local politics here in San Francisco, and a friend said something that rewrote my world:

I was pissed off after our election for Mayor went the wrong way - the former police chief beat the progressive incumbent after running on an anti-gay platform during the height of AIDS.

I was riding with a friend of mine, older than me and definitely wiser, who was a longtime student at the San Francisco Zen Center (perhaps an aspirant or acolyte? He lived there and was more than a novice for sure).

As I growled and seethed in the passenger seat, my friend said to me, quietly and calmly,

“Ram Dass had an expression for moments like these: ‘How now shall we live?’”

I was dumbstruck. Just like that, the scales fell and I got it.

To answer the challenge of “How now shall we live?” is to open our eyes with maximum clarity, in the light of day, and see with truth and courage the reality we see around us in this moment, unvarnished, unobstructed, uncompromising, to take a comprehensive and authentic look at and accounting of our world as it is -

and based on the truth of what we see, do the next right thing – it could be a small act or a large task, affecting just one person or situation or many, to make contact with someone or to repair a broken hinge or to run for office, it will have a million variations but as you think on this and give it focus your next right task will present itself to you, unique to you.

And when that task is done, that thing accomplished, repeat the process and do the next right thing, and the next one, and the next right thing after that, until it becomes second nature, it becomes part of your daily walk through life.

I have seen the positive effects of this approach in my own life and in the lives of others, and I’m not here to lie to you. It’s simple, it’s clear, it’s grounded in our true nature, and it yields positive results that make a tangible difference soon enough that you can begin to trust the process and build on your results.

I intend to make this approach my primary tool for effective resistance and sustained activism against this rotten, misbegotten Administration, and I hope that others will take all or part of this approach and integrate it into their own work as individuals and in their group efforts as well. It’s effective, it’s not complicated, and it gets results.

In this way, we can begin to make things right, and I am convinced that by doing the next right thing, consistently, with focus and intention, with care and clear intent, with enough of us using this approach and taking it to heart, we will drive back, disrupt, thwart, spoil, deflect, defang and defeat the plans and intentions of The Liar Donald Trump and his pack of slavering billionaires, enablers, enforcers, worshippers, and followers.

This fight is worth fighting. They do not have the right to disrupt our lives and our families and our freedom to live as we see fit, and there is nothing about supporting a victorious politician that grants them that power or the license to come waltzing in, order us around, and haul us off to some internment camp built by their construction cronies for kickbacks. ~~~ How now shall we live?

We shall live in ways and acts that reflect our true nature, which rise from the best in each of us.

We shall live in ways and acts that bring positive effects to our lives and the lives of others, that protect the vulnerable, the sick and the disabled,

that rebuke and repel the presence and actions of those who want to injure us, imprison us, strip us of our rights and dignity and humanity,

that renew and restore the basic decency and goodness of heart that has been missing from too many of us for too long.

We shall live with our heads held high, with strength and purpose and focus, with clear intent and forward motion and love for ourselves and for each other and for our world,

We shall live with joy in the present and real hope for the future.

And here, and now, we shall not lose heart.

We are brave enough and strong enough to fight for what we treasure in this world.

We know what matters. We know what to do.

We will fight, and we will win.

Don’t forget to breathe!

[lobotomy-lady]

hello ms lobotomy. i'm a woman who is interested in owning a gun for self defense (and getting proper gun training). however everyone i have talked to about gun safety has insisted i am 100% more likely to shoot an innocent person than ever successfully defend myself, that guns are useless at close range, that carrying a gun would make me more likely to get killed, etc etc, all around just making it seem like it's not worth it at all. what do you think?

These people fail to realize that just bc a ton of absolute fucking morons with 0 training & a paranoid personality type own guns & misuse them, it doesn't mean /you/ will. Your risk of shooting an innocent person is not nearly as high as those morons risk is if you are a smart, cautious, responsible, & trained individual rather than a trigger happy lunatic who drinks moonshine all day & thinks they're being gangstalked. I'd be interested to see the gender breakdown also bc I have a feeling as usual men are the ones most likely to shoot an innocent person by accident bc they are most likely to be impulsively violent in other regards as well.

An analogy for this would be someone saying "everyone has a 1 in 15 chance of dying of lung cancer" just bc 1 in 15 ppl will die of it, as if an individual person has no possible way of minimizing (or increasing) their personal risk, like choosing not to smoke. It's just a product of people misinterpreting statistics.

As for guns being useless at a close range, that's the dumbest shit I've ever heard bc the whole point of a gun is NOT LETTING THE ATTACKER GET CLOSE IN THE FIRST PLACE. Yes, if an attacker who is physically stronger than you gets close, they can take your weapon. This is true of knives, tasers, pepper spray, mace, brass knuckles, etc-the difference is all of those weapons are USELESS at a long or mid range-but the long & mid range is where women can fight the best way against a man, bc they can't use their strength against you until they're close enough to grab you.

Obviously it isn't foolproof. An attacker could sneak up on you and restrain you before you can draw your gun, that's a real possibility (& that is why it's incredibly important to develop a good sense of situational awareness & always be vigilant). There is no weapon or self defense strategy that will prevent 100% of attacks or dangerous situations, but you can make yourself more of a threat by training with a firearm. Don't pay attention to what other people say, if YOU think you can handle the responsibility of owning a lethal weapon & are willing to put in the work then that's all that matters.

[tanadrin]

As we age, it is almost as if we suffer a curse; every single thing in our body seems to work less well over time, and once we hit old age, it all seems to start breaking down rather quickly. Everything from how well we heal from injuries, to our immune system, to our senses seems to start falling apart at once.

As I understand it, the evolution of aging is the result of an almost accidental trade-off between reproductive fitness in the short term, and consequences for the individual member of the species in the long term. For instance, you have animals like octopuses and salmon who mate once then die, usually producing many hundreds of offspring. This is because lots of small cumulative adaptations that helped reproduction in the short term had negative consequences for the individual in the long term--but because these animals got so good at making that first reproductive opportunity really successful, the cost for fewer future opportunities to reproduce was (in terms of reproductive fitness) small. And over time their ancestors leaned harder and harder into this strategy.

Humans obviously aren't anywhere near that specialized. Our offspring are normally one at a time (and multiples are very high risk) and require a lot of care. Like all mammals, we nurse and look after our young. But there's still a degree of evolutionary tradeoff; base rates of disease and accident still make betting on reproductive opportunities too far in the future a losing proposition, and the act of giving birth is itself very dangerous for women, so it makes sense to still somewhat front-load our reproductive opportunities, and if we survive for a long time, to transition to a more supportive role for other members of the community (as indeed some hypothesize is the reason menopause evolved in the first place; but note male fertility also declines with age, even though there's no exact male equivalent to menopause).

So deleterious mutations that affect us mostly in our old age, or adaptations that come with a benefit in the short term, and with a high cost in the long term, probably built up in our genome for the same reasons that they did in that of octopuses and salmon, just in a less dramatic way. And so it makes sense that when we age, lots of things tend to go wrong. Aging isn't the product of a single process of system; it's the product of many systems in our bodies breaking down, because they have a degree of planned obsolescence built into them. This is why we shouldn't expect anti-aging interventions to be big dramatic breakthroughs that suddenly fix everything. We have lots of problems to deal with when it comes to "curing" aging, from shortening telomeres and waste products building up in our cells to UV damage to the eyes and loss of bone density, all from different sources.

Despite the image we may have absorbed from science fiction, longevity doesn't look like a single treatment that could easily be monopolized and sold at $100,000 a dose. It looks like hundreds of little things, many of which we're already working on quite diligently and making small-but-important breakthroughs in, and in areas where advances often go from "experimental and possibly very expensive" to "routinely available" in a couple of decades. And this makes sense too! Public health authorities and insurance companies have a vested interest in these advances--a treatment that improves the survival rate for a kind of cancer or helps to prevent heart disease means they have to pay less in more drastic, more expensive medical treatments down the line.