#leptine

[fitnessmith]

Perdre les kilos de l'été : Comprendre les variations saisonnières, perdre du gras et prendre du muscle

NOUVEAU 👉 Perdre les kilos de l'été : Comprendre les variations saisonnières, perdre du gras et prendre du muscle

Vous avez pris du bon temps cet été et vous vous demandez sûrement : “Pourquoi je prends du poids l’été ?” Et maintenant que l’été touche à sa fin, vous souhaitez vous remettre en forme ? Vous avez envie de perdre les kilos des vacances ou tout simplement faire une « détox » avant l’hiver ? Vous vous demandez peut-être : “Comment perdre les kilos de l’été ?” ou encore “Quelle est la meilleure…

[mandragoraeart]

Error 404: Leptin Not Found

Just some fat rat doodles by request of some friends taking a biochemistry paper.

[acid-onthefloor]

Look at these little mice in the example picture of today's lecture about fat cells!

he is one big adipocyte

[daintycosmos]

I keep switching between thinking Liv Schmidt is iconic and thinking she’s cringe

[funsimplethings]

[immunobuffoono]

The VECTRA Blood Panel

*Scroll to the bottom portion of this post to view my test results...

PSA: If you are struggling with a mystery illness and cannot find the "right" medical specialists, I do formally recommend making a request to your most trusted physician about a blood serum/plasma panel known as "VECTRA." Testing individual inflammatory markers like C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) will inform you about potential inflammation underway in your body, but VECTRA is far more comprehensive & can give you insight into your disease activity as compared to a large population of patients with diagnosed rheumatoid arthritis.

[Sort of Unnecessary Side Quest: HAVING A NEGATIVE ANA RESULT IS NOT A REASON FOR A PHYSICIAN'S DISMISSAL! Personally, I have consistently tested negative on ANA panels, and after 20 years of this horseshit, that god awful test is the sole reason for being dismissed by many, many specialists time and time and time and time and time again... A negative ANA alongside positive inflammatory markers (like CRP & ESR) is termed "seronegative." Seronegative autoimmune diseases, although far less common, are absolutely real and deserve the same attention from physicians as the more common, seropositive autoimmune diseases. VECTRA can help prove your pain is valid and needs treatment, especially in the face of a consistently negative ANA!]

VECTRA Panel Pros/Cons (& What It Can Do For You)

What it definitely means/can do to help expedite the diagnostic process:

Measures RA disease activity: VECTRA provides an objective score reflecting the level of inflammation and joint damage that is suspected to occur without appropriate and prompt treatment.

Monitors treatment response: Helps doctors determine whether a patient's RA treatment is working or if adjustments are needed.

Assesses risk of joint damage: Higher scores are associated with increased risk of progressive joint damage.

Incorporates multiple biomarkers: The test evaluates 12 proteins associated with inflammation and immune activation, offering a more comprehensive look at disease activity compared to single-marker tests (e.g., CRP alone).

What it could mean but is not definitive without further testing:

Could indicate active inflammation: A high VECTRA score suggests ongoing inflammation, but it does not pinpoint the exact cause. Additional testing is needed to determine if another condition (e.g., chronic infection, another autoimmune disease with similar features, certain types of cancer, etc.) is contributing.

Could correlate with other inflammatory conditions: While designed for RA, some biomarkers in the test can be elevated due to other inflammatory or autoimmune diseases.

Does not confirm or rule out RA: A high or low VECTRA score alone does not diagnose or exclude rheumatoid arthritis—other clinical criteria and tests (ANA, RF, Anti-CCP, Tissue Imaging, Gene Mutation Analysis, etc.) are required for a diagnosis.

What it does not mean/can't tell you/can't do for you:

Not Covered by All Insurances: VECTRA is a Labcorp-owned blood panel. Unfortunately, this privatization of services does mean that VECTRA may not be covered by certain health insurance plans. Be sure to check with your insurance company first before moving forward with testing.

Does not diagnose RA: VECTRA is a disease activity test, not a diagnostic test for rheumatoid arthritis specifically.

Does not differentiate between different autoimmune diseases: Elevated markers may suggest inflammation, but they do not confirm RA specifically. The test simply compares your disease activity with approximately 300,000 patients definitively diagnosed with RA and can help define the severity of the disease activity in your body.

Not useful for all RA patients: Some people, particularly those with low CRP levels or seronegative RA, may not get reliable results from this test.

Not a replacement for imaging or clinical assessment: While VECTRA provides valuable biomarker data, physical exams, imaging (X-rays, MRIs), and other lab tests remain essential for evaluating RA progression.

My VECTRA Blood Panel Results

What My Results Definitely Mean For Me:

My Vectra DA Score is 45, which falls into the high disease activity category.

A high Vectra score indicates that I have some sort of disease underway that is highly active & that correlates with an increased risk of radiographic progression (observable joint damage/erosion). In other words, I am dealing with a chronic, observable disease which is causing severe & ongoing damage to my body - resulting in multi-system organ involvement and an array of primary diagnoses that may rather be secondary comorbidities of my unnamed systemic illness instead. AKA it means I'm sick AF you guys. Literally all the time. For 20 fucking years straight.

My 1-year risk of radiographic progression is 7%, suggesting a predictable joint damage progression within the coming year if left untreated or mismanaged.

My highest inflammatory marker percentile result listed was EGF (Epidermal Growth Factor), which showed that, compared to the tested RA patients, I am in the >99th percentile for this inflammatory marker. This essentially means that, if continued to be left unmanaged, the progression of this disease could result in irreparable joint and tissue damage. [These higher percentile scores typically display which disease pathway that needs to be targeted in order to treat the condition.] (Example: Biologics that treat diseases like Crohn's often target Interleukin 6, an inflammatory cytokine that, for me, has always tested within the normal range. Long story short, this VECTRA panel helps pinpoint possibilities for treatment potentially [despite maybe never being able to give this a formal name], but due to the complexity of my case, we still have a long way to go and lots more tests to undergo before this gal could potentially see any sort of remission.)

Other Resources

"A Guide to Your VECTRA Molecular Result" as Published by Labcorp for Patients

"Guiding Rheumatoid Arthritis Treatment Decisions" (with regard to VECTRA results) as published by Labcorp for Patients

"Rheumatoid Arthritis Comprehensive Testing Capabilities" as Published by Labcorp for Patients

[munaeem]

Understanding Leptin and How Your Body Stores Calories: A Friendly Chat About Obesity and Health

Hey there! Let’s talk about something that’s been buzzing in the health world lately: leptin and its role in obesity. You might have heard the term thrown around, but what exactly is leptin, and why does it matter? And while we’re at it, let’s dive into how our bodies store calories—because, let’s face it, we’ve all wondered why that slice of cake seems to stick around longer than we’d like! I…

[cytgen]

Abstract Leptin is mainly produced from adipose tissue and released into the circulation. Circulating leptin binds to the leptin receptor (LEPR) in the brain, which activates signaling pathways that inhibit feeding and promote calorie expenditure. The leptin receptor (LEPR, also known as Ob-R) gene is located at chromosome 1p31. DNA methylation consists of addition a methyl group at position 5′ of the pyrimidine ring of the cytosines upstream of a guanine (dinucleotide CpG) catalyzed by DNA methyltransferases. Methylation of cytosine in CpG sites is an important epigenetic modification way that could suppress the gene expression. This study was conducted to reveal the role of leptin (-2548 G/A, rs7799039) and LEPR (-668 A/G, rs113711) gene polymorphisms in patients diagnosed with multiple myeloma (MM). Patients who were diagnosed with MM and followed-up in our clinic between January 2010 and January 2022 were included in the study. The genotypes of the leptin (-2548 G/A, rs7799039) and LEPR (-668 A/G, rs113711) genes were statistically compared between patients and healthy controls. Additionally, the statistically significant effects of these genotypes on survival were examined. In addition, the methylation status of the patients was compared to the healthy control group, and the effect on survival was evaluated. A total of 300 patients diagnosed with MM and 170 individuals to form a healthy control group were included in this study. In the statistical analysis performed to investigate the effect of leptin and LEPR gene polymorphisms on disease susceptibility, GA and AA genotypes of the leptin gene were found to be significantly higher in the patient group compared to healthy controls. In the statistical analysis for -31 NT and -51 NT methylation of the leptin gene, -51 NT methylation was found to be significantly higher in healthy controls (p = 0.002). In the survival analysis, progression-free survival (PFS) of patients with GG genotype of the LEPR gene was found to be significantly shorter compared to others, there was no effect on the overall survival. In the multivariate analysis, it was revealed that the PFS of patients with GG genotype of the LEPR gene was 2.02 times shorter compared to others (RR: 2.017; CI: 1.191–3.418, p = 0.009). MM and leptin polymorphisms have significant features in terms of both disease susceptibility and treatment response.

[kronieken]

Februari sprokkelmaand

Februari. Ooit genoemd als ‘Salmonath’, ‘Reinigingsmaand’ of ‘Mensis purgatorius’, ‘Sporkelmaand’ of ‘Sprokkelmaand’ en ook wel ‘Schrikkelmaand’ of ‘Spurkel’. De tweede dag van de sprokkelmaand was lang geleden nog een feestdag voor de knechten en de meiden op het platteland. Ze verlieten op 2 februari hun werkplekken om andere oorden op te zoeken en er eventueel te gaan trouwen. In 1844 zuiverde…

[dynamichealthinsights]

The Silent Saboteur: How Disrupted Sleep Wreaks Havoc on Your Hormones and Overall Health

We all cherish those mornings when we wake up feeling refreshed and ready to take on the day. But what happens when those mornings become rare, replaced by groggy, irritable starts? It’s not just about feeling tired; consistently disrupted sleep can set off a chain reaction within your body, throwing your hormones out of balance and affecting your health in ways you might not even realize. Let’s…

[solargazing]

leptin can promote neuron survival?? like.. it can protect neural progenitor and stem cells. kind of BONKERS. it can also improve memory and learning by changing gene expression within the hippocampus based on calorie intake

this info is from morrison’s article on leptin signaling in the brain: a link between nutrition and cognition

[tinashealthandbeauty]

Are you fed up with doing exercise and not getting in shape? You could be a leptin resistant person.

#guthealth #leptinresistance #obesity #bodyfat #exercise

Leptin resistance occurs when the body’s cells don’t respond properly to the hormone leptin, which plays a key role in regulating appetite and metabolism Symptoms may include persistent hunger, difficulty losing weight, and an increase in body fat. A potential treatment plan includes maintaining a balanced diet rich in whole foods, regular exercise to improve insulin sensitivity, and getting…

[cwbullet]

Research Proven Weight Loss: Omega-3 Fatty Acids

Omega-3: An Appetite Suppressant?  There is no such thing as a sure thing or a magic bullet when it comes to weight loss.  Around the globe, obesity and obesity-related illnesses represent a major public health challenge. The prognosis for citizens of the United States is exceptionally poor.  Unfortunately, there is no sunrise on the horizon and the prognosis is getting worse for children,…

[eatclean-bewhole]

For more on this, I recommend researching leptin resistance, when the body becomes less responsive to the effects of leptin. The better you know your body, the better choices you can make.

#weightloss #weightmanagement #ghrelin #leptin #hormones #hormonehealth #hormonebalance #leptinresistance #health #healthy #healthyliving #healthylife #healthylifestyle #nutrition #dieting #ozempic #weightlossshots #hormoneimbalance #wellness #guthealth #hormonesupport #selfcare #holistichealth #hormonebalancing #healthyhormones #didyouknow #healthtips #nutritionist