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The decision to undergo bone marrow transplantation (BMT) in a lymphoma patient is highly personalized and depends on several key factors:
• Histological Subtype: The specific form of lymphoma greatly influences treatment choices. For example, aggressive diffuse large B-cell lymphoma (DLBCL) or refractory Hodgkin lymphoma may require BMT.
• Disease Stage: The stage at the time of diagnosis plays a crucial role. BMT is often considered for advanced-stage lymphomas or those that have recurred after initial treatments.
• Response to Previous Therapies: Patients who do not achieve remission or experience a recurrence after traditional therapies may explore BMT as a treatment option.
• Age and Overall Health: The patient's age and general health significantly impact their ability to withstand the demanding BMT process.
• Donor Availability: In the case of allogeneic stem cell transplantation (allo-SCT), locating a compatible donor, typically a sibling or a well-matched unrelated individual, can be a complex undertaking.
A bone marrow transplant can be recommended in other medical conditions besides lymphoma, like leukemia, aplastic anemia, thalassemia, myeloma, and sickle cell disease. You can choose to undergo a bone marrow transplant from some of the best hospitals in Delhi. The cost of bone marrow transplant in Delhi will vary depending on the type and severity of condition being treated and the type of bone marrow transplant being performed.
#bone marrow transplant#cost of bone marrow transplant#bone marrow transplantation#lymphoma#leukemia#myeloma#aplastic anemia#sickle cell disease#thalassemia
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In a Bind
Multiple myeloma is a blood cancer affecting plasma cells, white blood cells that produce antibodies, causing them to multiply abnormally in the bone marrow. Right now, only half of patients can expect to survive five years after diagnosis, so better treatments are sorely needed. Promising targets include fatty acid-binding proteins (FABPs), a multi-functional family of proteins that can pick up lipids, involved in a variety of processes. A recent study found that cultured myeloma cells (pictured, their nuclei in blue) expressed high levels of one member in particular, FABP5 (in red); blocking it reduced cell proliferation, while patients with higher FABP5 levels tended to experience worse outcomes. Inhibiting FABPs more broadly appeared even more effective, improving survival in some mice with myeloma. To build on these results, further research needs to investigate why not all mice responded so well, and whether inhibiting FABPs would be safe and effective in humans.
Written by Emmanuelle Briolat
Image from work by Mariah Farrell and colleagues
Center for Molecular Medicine, Maine Health Institute for Research, Scarborough, ME, USA
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in eLife, March 2023
You can also follow BPoD on Instagram, Twitter and Facebook
#science#biomedicine#myeloma#haemato-oncology#haematology#bone marrow#oncology#white blood cells#fatty acid binding proteins#cancer#blood cancer#immunofluorescence
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PET Scan for Multiple Myeloma: Diagnosis and Staging
Multiple Myeloma is a type of cancer that affects plasma cells in the bone marrow. Plasma cells are a type of white blood cells that produce antibodies to fight infections. When these cells become cancerous, they produce abnormal proteins that can cause various health problems, such as bone pain, anemia, kidney problems, and infections.
Early diagnosis and proper staging of multiple myeloma are crucial for effective treatment and improved outcomes. One of the most effective diagnostic tools for multiple myeloma is a PET (positron emission tomography) scan. In this blog post, we will discuss the role of PET scan in the diagnosis and staging of multiple myeloma.
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How Does Multiple Myeloma Kill You: Symptoms And Survival Rate
Multiple myeloma is a rare bone marrow cancer that affects your plasma cells. Multiple myeloma symptoms can differ based on what stage you’re at in cancer. In the early stages, these symptoms may not appear; if they do, the first signs include pain in the bones. Other myeloma symptoms include weakness, vomiting, nausea, easy bruising, etc.
how does multiple myeloma kill you
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SUP DIGITAL PEEPS OUT IN THE WEB WORLD!!!! mkgtweety HERE!!!! IN ANOTHER EPISODE OF: "WHAT'S BEEN GOING ON W/ ME IN THE LAST 3 MONTHS", I SIT DOWN ON MY WRAP-AROUND PORCH AND TALK 'BOUT WHAT'S BEEN GOING ON W/ ME AND WHAT HAPPENED SINCE THE LAST 3 MONTHS' UPDATE VID!!!! SUCH AS, WHAT HAPPENED WHEN I WENT 2 MY 3-MONTH DOCTOR'S CHECKUP 4 MY TYPE 2 DIABETES ON AUG. 26, 2024!!!! I ALSO TALK 'BOUT WHAT'S BEEN GOING ON W/ MY MOM AND DAD SINCE THE LAST 3 MONTHS' UPDATE VID I MADE!!!! P.S. THIS IS THE 1st VID I'VE UPLOADED FROM MY NEW PC THAT I GOT FOR X-MAS OF LAST YEAR FROM "CLAUSE"!!!!
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FDA Menyetujui Idecabtagene Vicleucel untuk Multiple Myeloma Setelah 2 atau Lebih Jalur Terapi
Majalah Farmasetika – Persetujuan ini memperluas indikasi sebelumnya dari idecabtagene vicleucel (Abecma; Bristol Myers Squibb), yang akan membuat obat tersedia untuk pasien pada jalur sebelumnya. FDA telah menyetujui idecabtagene vicleucel (Abecma; Bristol Myers Squibb) untuk pengobatan multiple myeloma yang kembali atau refrakter pada orang dewasa yang menerima 2 atau lebih jalur terapi…
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When there is an irregular change in the blood(form, shape, or count ) a person can not survive without its cure. One of the deadliest diseases of blood is blood cancer. Millions of people died due to this disease because it is difficult to cure it.
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Max Payne Voice Actor James McCaffrey Passes Away At 65
New Post has been published on https://thedigitalinsider.com/max-payne-voice-actor-james-mccaffrey-passes-away-at-65/
Max Payne Voice Actor James McCaffrey Passes Away At 65
James McCaffrey, actor best known to video game fans as the voice of Max Payne, among other characters, has passed away. He was 65.
TMZ reports that McCaffrey died on Sunday after a battle with multiple myeloma, a form of cancer. A rep for McCaffrey tells the outlet that the actor died surrounded by friends and family.
McCaffrey’s extensive on-screen credits include roles in Law & Order, Suits, and Blue Bloods, and video games such as 2008’s Alone in the Dark and 2005’s Area 51. However, Remedy fans knew him best as the voice of Max Payne in all three entries. Furthermore, McCaffrey voiced Thomas Zane in Alan Wake, Zachariah Trench in Control, and, most recently, Alex Casey in Alan Wake 2.
We are deeply saddened to hear about the passing of our beloved friend and collaborator James McCaffrey, the iconic voice of Max Payne and Alex Casey. His remarkable talent gave life to our characters and left an enduring impact on our community. Our hearts go out to his family. pic.twitter.com/GEJL7aXyNt
— Remedy Entertainment (@remedygames) December 18, 2023
In a separate X thread, Remedy creative director Sam Lake offered his condolences as well.
I’m heartbroken to hear the sad news of James McCaffrey’s passing. We worked together for more than 25 years. He was a lovely man and a dear friend. He was a key part of the Remedy family. He was a brilliant actor. No one could do what he did better than him. (1/2) pic.twitter.com/JLcEIMUT43
— Sam Lake (@SamLakeRMD) December 18, 2023
Game Informer extends its condolences to McCaffrey’s family and loved ones.
[Source: TMZ]
#2023#amp#Blue#Cancer#Community#Dark#december#entertainment#form#game#games#law#life#max#myeloma#News#One#Other#Roles#styles#talent#twitter#Video#Video games#voice#X
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𝐂𝐚𝐧𝐜𝐞𝐫 𝐛𝐢𝐨𝐥𝐨𝐠𝐲: This research focuses on understanding the #molecular and #cellular mechanisms of cancer development and progression. 𝐂𝐚𝐧𝐜𝐞𝐫 𝐠𝐞𝐧𝐨𝐦𝐢𝐜𝐬: This research focuses on identifying and understanding the #geneticchanges that contribute to cancer development.
Visit @ https://symbiosisonlinepublishing.com/cancerscience-research/
#cancerbiology#CancerGenomics#Cancer#cancerresearch#CancerScience#tumor#StemCellBiology#molecularbiology#apoptosis#lymphoma#sarcoma#lymphedema#lungcancer#skincancer#myeloma#catheter#journal#journals#pubmed#peerreview#OpenAccess#openaccessjournal#symbiosisonlinepublishing
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#bloodcancerspecialist#hematologist#oncologist#leukemia#lymphoma#myeloma#bloodcancer#bloodcancerawareness#bloodcancertreatment#bloodcancersurvival#bloodcancerfighter#bloodcancerwarrior#bloodcancerhope#bloodcancerlove#bloodcancerstrong
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The selection of treatment for leukemia is influenced by various factors, including the specific type of leukemia, the patient's age, overall health, and genetic factors. Here are some of the primary therapeutic strategies:
Chemotherapy: Chemotherapy is a frequently employed approach for leukemia treatment. It entails the use of medications to either eliminate blood cancer cells or impede their growth. Chemotherapy can be administered orally, intravenously, or via injections and is often combined with other treatments like radiation therapy or stem cell transplantation. The chemotherapy regimens vary based on the type and stage of leukemia. For instance, aggressive chemotherapy may be necessary for inducing remission in cases of ALL or AML. Patients typically undergo multiple cycles of chemotherapy with breaks in between to allow their bodies to recover from side effects.
Radiation Therapy: Radiation therapy employs high-energy X-rays or other radiation forms to target and destroy cancer cells. It is especially effective in treating leukemia that has spread to specific body areas, such as the central nervous system. Often, radiation therapy is used alongside chemotherapy. Radiation therapy is tailored to each patient's individual requirements and can be administered externally through machines directing radiation beams at the affected area or internally via the placement of radioactive materials near leukemia cells.
Targeted Therapy: Targeted therapy is a more recent advancement in leukemia treatment and involves drugs designed to specifically disrupt mechanisms enabling leukemia cell growth and division. These drugs have shown promise in treating specific leukemia types, like chronic myeloid leukemia (CML). Targeted therapy drugs, such as Imatinib for CML, work by inhibiting specific proteins responsible for leukemia cell growth. They are often utilized as long-term treatments, helping patients achieve and maintain remission with fewer side effects compared to traditional chemotherapy.
Stem Cell Transplantation: Stem cell transplantation, also known as bone marrow transplantation, is a procedure where healthy stem cells are transplanted into the patient's body to replace damaged or cancerous cells. This bone marrow transplant treatment is often employed in cases of acute leukemia when other treatments have proven ineffective. Stem cell transplantation can be autologous, using the patient's own stem cells, or allogeneic, involving stem cells from a compatible donor. Allogeneic bone marrow transplants require close donor-recipient matching and are associated with a higher risk of complications but offer a potential cure for specific leukemia types.
Immunotherapy: Immunotherapy is an emerging approach that harnesses the body's immune system to target and eliminate cancer cells. CAR-T cell therapy, a form of immunotherapy, has shown significant promise in treating specific leukemia types, particularly acute lymphoblastic leukemia (ALL). CAR-T cell therapy entails genetically modifying a patient's T cells to recognize and attack leukemia cells. These modified T cells are reintroduced into the patient's body, where they locate and destroy cancer cells. While CAR-T therapy has exhibited remarkable success, it can also lead to severe side effects, including cytokine release syndrome, necessitating careful monitoring and management.
Supportive Care: Effectively managing the side effects and complications of leukemia and its treatments is crucial. Supportive care may involve blood transfusions to address anemia and low platelet counts, antibiotics to prevent infections, and medications to alleviate pain and discomfort.
Patients undergoing leukemia treatment or treatment of other blood disorders, like myeloma or lymphoma, typically require a multidisciplinary approach involving oncologists, hematologists, nurses, and other healthcare professionals. Regular monitoring and adjustments to treatment plans are common practices to ensure the best possible outcomes. You can find some of the best medical specialists and healthcare team in reputed hospitals situated at Delhi.
The cost of leukemia treatment will vary depending on the type of treatment being performed. The cost of bone marrow transplant in Delhi typically varies between INR 8,00,000 to INR 15,00,000.
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Unleashing the Power Within: A Patient's Guide to CAR-T Therapy
Discover the potential of CAR-T therapy to unleash the power within: Explore ongoing trials, FDA-approved products, and side effect management. #carttherapy, #celltherapy, #cartcelltherapy, #immunotherapy, #USFDA, #FDAapproval, #lymphoma, #lymphomaawareness, #leukemia, #leukemiaawareness, #Myeloma, #myelomaawareness,
Welcome to MindfulCells Blog, your patient ultimate guide to CAR-T cell therapy, a groundbreaking form of immunotherapy revolutionizing cancer treatment. Discover how this incredible FDA approved CAR T treatment harnesses your immune system’s power to combat cancer cells and transform lives. CAR T therapyIt combines cell and gene therapy – T cells and CAR T cells are a type of white blood cells…
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#cancertreament#cart cell therapy#cart therapy#cell therapy#fdaapproval#immunotherapy#leukemia#lymphoma#myeloma#usfda
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https://www.cancersurgerypune.com/
#BloodCancerSpecialist#PimpriChinchwad#DrAshishPokharka#Leukemia#Myeloma#CancerTreatment#PersonalizedCare#AdvancedFacilities
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VID MADE ON: 06/15/2024!!!! SUP DIGITAL PEEPS!!!! ****SORRY 4 THE "SPLOTCHY REDNESS" IN THE MIDDLE OF MY FACE IN THE THUMBNAIL AND IN THE VID!!!! I HAVE DRY SKIN IN THOSE PARTS OF MY FACE, AND WHEN I SCRATCH OFF THE FLAKING SKIN, I GET "SPLOTCHY REDNESS" DIGITAL PEEPS!!!! DON'T WORRY, I HAVE STUFF I'VE BEEN PUTTING ON MY FACE 2 HELP THE "SPLOTCHY REDNESS" GO AWAY"!!!!**** IN PART 2 OF THIS VID CALLED: 'WHAT'S BEEN GOING ON IN MY LIFE THE LAST 3 MONTHS', I FINISH TELLING YOU WHAT'S BEEN GOING ON W/ MY MOM IN THE LAST 3 MONTHS W/ HER SINCE I MADE MY LAST VID B4 THIS 1 'BOUT MY MOM AND ME!!!! AFTER THAT, TELL YOU WHAT'S GOING ON W/ MY DAD'S BAND THAT HE PLAYED DRUMS FOR!!!! (WELL, MORE LIKE "USED" 2 PLAY FOR NOW DIGITAL PEEPS!!!!) THEN, AT LAST, I TELL YOU WHAT'S GOING ON IN MY LIFE!!!!
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WATCH THE VID B4 THIS 1 TO KNOW WHAT I'M TALKING 'BOUT IN THE VID: "WHAT'S BEEN GOING ON WITH MY MOM & ME LATELY!!!!": https://www.youtube.com/watch?v=lxOZOOT_M90
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Top 5 Proven Ways To Care For Multiple Myeloma
Multiple Myeloma, a kind of blood cancer, can be devastating for the patient and their caregivers. It is the third most common blood cancer after lymphoma and leukemia and the most common type of plasma-cell cancer.
The nature of myeloma is that it keeps changing with time, and so do the needs of the patient. It’s natural for the patient and their loved ones to go through emotional and physical turmoil because of the turbulent nature of myeloma. One rule of the thumb is to cultivate a mindset that accepts change as the norm.
In this article, we help you understand the condition better, so you can take better care of yourself and stay on top of managing myeloma.
What Is Multiple Myeloma?
Multiple myeloma is a cancer that’s related to the plasma cells, i.e. the white blood cells (WBC) that are part of your immune system. WBCs produce antibodies that fight infection. Plasma cells grow in the bone marrow, the spongy tissue in the center of your bones.
Myeloma occurs when the bone marrow produces too many abnormal or cancerous plasma cells that crowd out the healthy plasma cells. The abnormal, cancerous plasma cells make monoclonal protein or M protein, an unwanted antibody protein with no purpose in the body, except to damage it. The cancerous cells clump together and form bone tumors.
While myeloma starts in the bone marrow, it can spread to multiple parts of the body.
What Are The Signs And Symptoms Of Multiple Myeloma?
There may not be signs of myeloma in the initial states. But you will notice some of the following symptoms in the advanced stages. Watch out for these signs of multiple myeloma.
Bone pain, especially in your chest and ribs, spine and lower back.
Frequent infections
Unexplained rapid weight loss
Breathing difficulties
Nausea
Weakness
Tiredness
Mental fogginess
Constipation
Loss of appetite
Excessive thirst
Numbness or tingling sensation in your hands and feet
Bleeding
Anemia
Fever
Too much calcium in the blood (hypercalcemia)
High levels of protein in the urine
Bone fractures
Kidney damage
You should consult your primary care doctor in Campbell if you have any of the above symptoms.
What Is The Cause Of Multiple Myeloma?
There is no known cause of multiple myeloma. However, you may be at a higher risk of myeloma if you meet these conditions:
Advancing age
Overweight or obese
Male
Family history of multiple myeloma
Personal history of Monoclonal Gammopathy of unknown significance
Exposure to radiation and harmful chemicals
What Are The Complications Of Multiple Myeloma?
There are other health complications that are associated with multiple myeloma that include:
Frequent infections
Blood problems such as anemia
Bone problems such as bone pain, thinning of the bones and broken bones.
Deteriorated kidney functioning that can lead to kidney failure.
Diagnosis And Treatment For Multiple Myeloma
Multiple myeloma can be treated when diagnosed early and controlled effectively. Diagnostic tests for myeloma include:
Blood tests
Urinalysis
PET CT
X-rays
Bone marrow biopsy
The doctor will recommend a customized treatment plan based on the patient’s stage of myeloma. It helps in killing cancer cells, tackling bone tumors, managing any kind of infection and reducing inflammation. The treatment options include:
Medications for pain relief
Chemotherapy
Immunotherapy
Radiation
Targeted therapy
Stem cell transplant
How To Take Care Of Yourself With Multiple Myeloma
Multiple myeloma is a progressive condition which worsens with time. If your loved one has multiple myeloma, there will be times when they’ll feel better and times when they’ll feel worse as the symptoms return.
Here’s what you can do to help your loved one who’s suffering myeloma during their treatment and remission so they can stay healthy.
Schedule Follow-Up Medical Appointments
When you’re in remission, your doctors and care team will want to observe your health like any changes in your bone pain or looking for any frequent infections.
It’s critical to schedule and attend all your follow-up appointments, which may include blood tests and bone scans to check if your disease is progressing or contained. If your condition is worsening, your doctors will most likely suggest different treatments or follow a different approach to the current treatment plan.
Also, a person with multiple myeloma needs to be regular with their follow-up medical appointments, as they are at a higher risk of getting an infection than those without the condition. Some infections are:
Urinary tract infections
Blood infection
Pneumonia
Fungal infections or viral infections like influenza
The doctor will use preventive strategies such as vaccination, medication, and intravenous immunoglobulin (IVIG) to help lower the risk of infections.
Adapt to your loved one’s changing care needs
Since multiple myeloma is a progressive disease, the needs of your loved one will also change with the symptoms in that particular cycle. Call your doctor immediately when you notice any abnormality or symptoms.
As treatment changes as per your loved one’s current condition, you’ll need to keep track of all their medications.
The various medical procedures can be daunting for your loved one with multiple myeloma. Be an emotional support for them and motivate them to prepare and complete all their treatment procedures. You will need to help them with their daily medications and other routine procedures to help them remain healthy.
Keep the lines of communication open always and talk in a tone that encourages them to open up about how they’re feeling so you can listen and understand their fears and needs.
Track their progress and all the health changes and discuss this list with the doctor.
Recover with a balanced diet
Nutrition is a vital part of multiple myeloma recovery.
Eating timely, well-balanced meals during and after the treatment can significantly improve the way your loved one feels. Proper nutrition will give them the strength, vitality and speed up their recovery process. Include high-quality protein to help your loved one’s body and immune system recover and whole grain to help them maintain their energy levels.
Eating 5-6 small meals throughout the day will help your loved one stay nourished without overeating. Opt for bland instead of spicy and deep-fried foods. Your loved one can have fruits and vegetables to up their antioxidants intake. They can include healthy fats such as olive oil, nuts, seeds, and avocado.
Drink adequate water daily, and avoid excess caffeine. Also, avoid or limit alcohol consumption, as excessive drinking can harm your loved one’s immune system.
Since unexplained rapid weight loss is a symptom of multiple myeloma, the focus should be on keeping a healthy weight. A balanced diet recommended by the doctor will help your loved one from gaining or losing too much weight.
Exercise with caution
Multiple myeloma can put your loved one at risk of mobility problems, falls, and fractures.
Before they start any physical activity and exercise, it’s best to consult the doctor to assess them. The doctor can recommend a customized exercise plan - the kind of exercises they can do, what they must avoid, how many times to exercise in a week, intensity and duration of the exercise. They can also recommend your loved one to work with a physical therapist.
Manage stress caused by multiple myeloma
Stress and myeloma go together, and it can make your loved one anxious as they undergo the treatment. Stress isn’t good, especially for people with myeloma, a cancer that damages the bone marrow, which typically boosts the immune system by making antibody producing cells. Stress can make your loved one’s myeloma worse, as it significantly weakens the immune system.
While it might be hard for your loved one to lower their stress levels on their own, you can help support them in relieving their anxiety.
Talking to your doctor’s recommended psychiatrist or professional counselor will help your loved one. A lot of patients see the change in their stress levels in the first week of consultation. Ask them about whether your loved one should take an antidepressant or anti-anxiety medications.
Your loved one can have a trusted circle of family members and friends with whom they can share their feelings.
Sleep is essential for having a relaxed mind and better recovery. If your loved one cannot sleep because of anxiety, your doctor might suggest prescription sleeping pills for a certain period.
Encourage your loved one to take time to destress everyday through deep breathing techniques, meditation, listening to their soothing and uplifting music, and taking a walk.
Assure them that what their feeling is normal, and this too shall pass once their treatment is over and they're on their healing path.
Your support can help your loved one manage their multiple myeloma
Living with multiple myeloma can be challenging. Your support can help your loved one with multiple myeloma stay as healthy as possible.
Discuss with their doctor about their fears and doubts around multiple myeloma and its effect on their life. The best doctor in Campbell can adjust their medication, diet, enhance their electrolyte and fluid intake, and help them find a psychiatrist for boosting their mental health.
You can support your loved one to go for follow-up medical appointments, eat a well-balanced diet, get regular exercise as recommended by the doctor, quit smoking and alcohol, rest well, take counseling if required to manage stress and depression, and limit contact with people who are sick.
Your love and support will make it easier for your loved one with multiple myeloma to cope and remain positive throughout the treatment journey and remission period.
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