#myeloma

[drforambhuta]

The decision to undergo bone marrow transplantation (BMT) in a lymphoma patient is highly personalized and depends on several key factors:

• Histological Subtype: The specific form of lymphoma greatly influences treatment choices. For example, aggressive diffuse large B-cell lymphoma (DLBCL) or refractory Hodgkin lymphoma may require BMT.

• Disease Stage: The stage at the time of diagnosis plays a crucial role. BMT is often considered for advanced-stage lymphomas or those that have recurred after initial treatments.

• Response to Previous Therapies: Patients who do not achieve remission or experience a recurrence after traditional therapies may explore BMT as a treatment option.

• Age and Overall Health: The patient's age and general health significantly impact their ability to withstand the demanding BMT process.

• Donor Availability: In the case of allogeneic stem cell transplantation (allo-SCT), locating a compatible donor, typically a sibling or a well-matched unrelated individual, can be a complex undertaking.

A bone marrow transplant can be recommended in other medical conditions besides lymphoma, like leukemia, aplastic anemia, thalassemia, myeloma, and sickle cell disease. You can choose to undergo a bone marrow transplant from some of the best hospitals in Delhi. The cost of bone marrow transplant in Delhi will vary depending on the type and severity of condition being treated and the type of bone marrow transplant being performed.

[bpod-bpod]

In a Bind

Multiple myeloma is a blood cancer affecting plasma cells, white blood cells that produce antibodies, causing them to multiply abnormally in the bone marrow. Right now, only half of patients can expect to survive five years after diagnosis, so better treatments are sorely needed. Promising targets include fatty acid-binding proteins (FABPs), a multi-functional family of proteins that can pick up lipids, involved in a variety of processes. A recent study found that cultured myeloma cells (pictured, their nuclei in blue) expressed high levels of one member in particular, FABP5 (in red); blocking it reduced cell proliferation, while patients with higher FABP5 levels tended to experience worse outcomes. Inhibiting FABPs more broadly appeared even more effective, improving survival in some mice with myeloma. To build on these results, further research needs to investigate why not all mice responded so well, and whether inhibiting FABPs would be safe and effective in humans.

Written by Emmanuelle Briolat

Image from work by Mariah Farrell and colleagues

Center for Molecular Medicine, Maine Health Institute for Research, Scarborough, ME, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, March 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[zarrin99]

PET Scan for Multiple Myeloma: Diagnosis and Staging

Multiple Myeloma is a type of cancer that affects plasma cells in the bone marrow. Plasma cells are a type of white blood cells that produce antibodies to fight infections. When these cells become cancerous, they produce abnormal proteins that can cause various health problems, such as bone pain, anemia, kidney problems, and infections.

Early diagnosis and proper staging of multiple myeloma are crucial for effective treatment and improved outcomes. One of the most effective diagnostic tools for multiple myeloma is a PET (positron emission tomography) scan. In this blog post, we will discuss the role of PET scan in the diagnosis and staging of multiple myeloma.

[universitycancercentres]

How Does Multiple Myeloma Kill You: Symptoms And Survival Rate

Multiple myeloma is a rare bone marrow cancer that affects your plasma cells. Multiple myeloma symptoms can differ based on what stage you’re at in cancer. In the early stages, these symptoms may not appear; if they do, the first signs include pain in the bones. Other myeloma symptoms include weakness, vomiting, nausea, easy bruising, etc.

how does multiple myeloma kill you

[mkgtweety]

UPDATE ON THIS VID: ON 01/28/2025 MY DAD HAD HIS HEART CATH THING!!!! HE DID WELL W/ FLYING COLORS!!!! PLUS THE DOCS SAID HE CAN GO AHEAD AND HAVE HIS SPINAL SURGERY ON: APR. 24, 2025!!!! YEA 4 MY DAD DIGITAL PEEPS!!!! {I'VE PLACED THIS IN THE INFO BOX OF THIS VID DIGITAL PEEPS!!!!}

SUP DIGITAL PEEPS OUT IN THE WEB💻WORLD!!!! IT'S YOUR FAV.🥰😘 DIGITAL PEEP IN THE WORLD: mkgtweety!!!! I MADE THIS VID ON MY WEBCAM💻FROM MY NEW PC!!!! IN THIS VID📹MADE ON: JAN. 22, 2025, I GIVE YOU UPDATES ON WHAT'S GOING ON W/ MY MOM, MY DAD, AND ME OVER THE LAST COUPLE OF MONTHS🗓️SINCE OUR LAST VID I MADE!!!! IN THE VID, I TALKED ABOUT HOW I WENT TO A WEDDING💒👰‍♀️🤵‍♂️ON DEC. 7, 2024!!!! WELL, I MADE AN INSTAGRAM VID📹TALKING ALL ABOUT IT!!!! HERE'S THE LINK TO IT: https://www.instagram.com/p/DDmAtGVMUD3/

P.S. YES, DIGITAL PEEPS, IN MY THUMBNAIL, MY 1 EYE IS HALF GREEN AND HALF BROWN!!!!

SUBSCRIBE IF YOU LIKE WHAT YOU SEE AND WHAT I DO!!!! AND IF YOU REALLY, REALLY LIKE IT HIT THE THUMBS-UP BUTTON!!!!

LINKS 2 MY 1st 2 VIDS I POSTED ON2 THIS CHANNEL: {HOW I GOT MY OTHER/MAIN ACCT: “mkgtweety” SUSPENDED OVER SOMETHING STUPID I DID HERE AT YOUTUBE!!!! PLEASE WATCH THESE VIDS!!!! PART 1 1st THEN PART 2 2nd IT WILL HELP EXPLAIN HOW I GOT MY OTHER OTHER/MAIN ACCT: “mkgtweety” SUSPENDED!!!!}

LINK 2 PART 1: https://www.youtube.com/watch?v=4sBINjtVgj0&feature=youtu.be

LINK 2 PART 2: https://www.youtube.com/watch?v=64XtKJoumRg&feature=youtu.be

I GOT A NEW DIGITAL CAMERA FROM AMAZON, AND I'M HAVING A PROBLEM W/ IT!!!! I'VE POSTED 'BOUT IT ON MY TUMBLR AND ALSO MADE A VID 'BOUT IT ON MY INSTAGRAM!!!! SO, IF U WOULD LIKE 2 HELP ME, HERE ARE THE LINKS WHERE I'VE POSTED THE PROBLEM I'M HAVING:

(YOU CAN LEAVE ME YOUR THOUGHTS IN THE COMMENTS SECTION OF EACH POST!!!! THANX DIGITAL PEEPS!!!!) THE INSTAGRAM VID I MADE 'BOUT IT: https://www.instagram.com/p/C6rNTJzMa8u/

THE TUMBLR POST I MADE 'BOUT IT: https://mkgtweety.tumblr.com/post/750135717707022336/i-have-a-problem-i-hope-u-can-help-me-digital

MY SOCIALS:

TUMBLR: {my childcare blog!!!!} https://mkgtweety.tumblr.com/

X {A.K.A "TWITTER"}: https://x.com/mkgtweety/

BLUESKY: https://bsky.app/profile/mkgtweety.bsky.social

INSTAGRAM: https://www.instagram.com/mkgtweety/

PINTEREST: https://www.pinterest.com/mkgtweety/

WATTPAD: https://www.wattpad.com/user/mkgtweety

[biology-geology-beaches-india]

TSRNOSS< p456.

[cytgen]

Abstract Leptin is mainly produced from adipose tissue and released into the circulation. Circulating leptin binds to the leptin receptor (LEPR) in the brain, which activates signaling pathways that inhibit feeding and promote calorie expenditure. The leptin receptor (LEPR, also known as Ob-R) gene is located at chromosome 1p31. DNA methylation consists of addition a methyl group at position 5′ of the pyrimidine ring of the cytosines upstream of a guanine (dinucleotide CpG) catalyzed by DNA methyltransferases. Methylation of cytosine in CpG sites is an important epigenetic modification way that could suppress the gene expression. This study was conducted to reveal the role of leptin (-2548 G/A, rs7799039) and LEPR (-668 A/G, rs113711) gene polymorphisms in patients diagnosed with multiple myeloma (MM). Patients who were diagnosed with MM and followed-up in our clinic between January 2010 and January 2022 were included in the study. The genotypes of the leptin (-2548 G/A, rs7799039) and LEPR (-668 A/G, rs113711) genes were statistically compared between patients and healthy controls. Additionally, the statistically significant effects of these genotypes on survival were examined. In addition, the methylation status of the patients was compared to the healthy control group, and the effect on survival was evaluated. A total of 300 patients diagnosed with MM and 170 individuals to form a healthy control group were included in this study. In the statistical analysis performed to investigate the effect of leptin and LEPR gene polymorphisms on disease susceptibility, GA and AA genotypes of the leptin gene were found to be significantly higher in the patient group compared to healthy controls. In the statistical analysis for -31 NT and -51 NT methylation of the leptin gene, -51 NT methylation was found to be significantly higher in healthy controls (p = 0.002). In the survival analysis, progression-free survival (PFS) of patients with GG genotype of the LEPR gene was found to be significantly shorter compared to others, there was no effect on the overall survival. In the multivariate analysis, it was revealed that the PFS of patients with GG genotype of the LEPR gene was 2.02 times shorter compared to others (RR: 2.017; CI: 1.191–3.418, p = 0.009). MM and leptin polymorphisms have significant features in terms of both disease susceptibility and treatment response.

[bidhuan]

FDA Menyetujui Idecabtagene Vicleucel untuk Multiple Myeloma Setelah 2 atau Lebih Jalur Terapi

Majalah Farmasetika – Persetujuan ini memperluas indikasi sebelumnya dari idecabtagene vicleucel (Abecma; Bristol Myers Squibb), yang akan membuat obat tersedia untuk pasien pada jalur sebelumnya. FDA telah menyetujui idecabtagene vicleucel (Abecma; Bristol Myers Squibb) untuk pengobatan multiple myeloma yang kembali atau refrakter pada orang dewasa yang menerima 2 atau lebih jalur terapi…

[healthygo]

When there is an irregular change in the blood(form, shape, or count ) a person can not survive without its cure. One of the deadliest diseases of blood is blood cancer. Millions of people died due to this disease because it is difficult to cure it.

[jcmarchi]

Max Payne Voice Actor James McCaffrey Passes Away At 65

New Post has been published on https://thedigitalinsider.com/max-payne-voice-actor-james-mccaffrey-passes-away-at-65/

Max Payne Voice Actor James McCaffrey Passes Away At 65

James McCaffrey, actor best known to video game fans as the voice of Max Payne, among other characters, has passed away. He was 65.

TMZ reports that McCaffrey died on Sunday after a battle with multiple myeloma, a form of cancer. A rep for McCaffrey tells the outlet that the actor died surrounded by friends and family.

McCaffrey’s extensive on-screen credits include roles in Law & Order, Suits, and Blue Bloods, and video games such as 2008’s Alone in the Dark and 2005’s Area 51. However, Remedy fans knew him best as the voice of Max Payne in all three entries. Furthermore, McCaffrey voiced Thomas Zane in Alan Wake, Zachariah Trench in Control, and, most recently, Alex Casey in Alan Wake 2.

We are deeply saddened to hear about the passing of our beloved friend and collaborator James McCaffrey, the iconic voice of Max Payne and Alex Casey. His remarkable talent gave life to our characters and left an enduring impact on our community. Our hearts go out to his family. pic.twitter.com/GEJL7aXyNt

— Remedy Entertainment (@remedygames) December 18, 2023

In a separate X thread, Remedy creative director Sam Lake offered his condolences as well. 

I’m heartbroken to hear the sad news of James McCaffrey’s passing. We worked together for more than 25 years. He was a lovely man and a dear friend. He was a key part of the Remedy family. He was a brilliant actor. No one could do what he did better than him. (1/2) pic.twitter.com/JLcEIMUT43

— Sam Lake (@SamLakeRMD) December 18, 2023

 Game Informer extends its condolences to McCaffrey’s family and loved ones.

[Source: TMZ]

[symbiosisonlinepublishing]

𝐂𝐚𝐧𝐜𝐞𝐫 𝐛𝐢𝐨𝐥𝐨𝐠𝐲: This research focuses on understanding the #molecular and #cellular mechanisms of cancer development and progression. 𝐂𝐚𝐧𝐜𝐞𝐫 𝐠𝐞𝐧𝐨𝐦𝐢𝐜𝐬: This research focuses on identifying and understanding the #geneticchanges that contribute to cancer development.

Visit @ https://symbiosisonlinepublishing.com/cancerscience-research/

[drforambhuta]

The selection of treatment for leukemia is influenced by various factors, including the specific type of leukemia, the patient's age, overall health, and genetic factors. Here are some of the primary therapeutic strategies:

Chemotherapy: Chemotherapy is a frequently employed approach for leukemia treatment. It entails the use of medications to either eliminate blood cancer cells or impede their growth. Chemotherapy can be administered orally, intravenously, or via injections and is often combined with other treatments like radiation therapy or stem cell transplantation. The chemotherapy regimens vary based on the type and stage of leukemia. For instance, aggressive chemotherapy may be necessary for inducing remission in cases of ALL or AML. Patients typically undergo multiple cycles of chemotherapy with breaks in between to allow their bodies to recover from side effects.

Radiation Therapy: Radiation therapy employs high-energy X-rays or other radiation forms to target and destroy cancer cells. It is especially effective in treating leukemia that has spread to specific body areas, such as the central nervous system. Often, radiation therapy is used alongside chemotherapy. Radiation therapy is tailored to each patient's individual requirements and can be administered externally through machines directing radiation beams at the affected area or internally via the placement of radioactive materials near leukemia cells.

Targeted Therapy: Targeted therapy is a more recent advancement in leukemia treatment and involves drugs designed to specifically disrupt mechanisms enabling leukemia cell growth and division. These drugs have shown promise in treating specific leukemia types, like chronic myeloid leukemia (CML). Targeted therapy drugs, such as Imatinib for CML, work by inhibiting specific proteins responsible for leukemia cell growth. They are often utilized as long-term treatments, helping patients achieve and maintain remission with fewer side effects compared to traditional chemotherapy.

Stem Cell Transplantation: Stem cell transplantation, also known as bone marrow transplantation, is a procedure where healthy stem cells are transplanted into the patient's body to replace damaged or cancerous cells. This bone marrow transplant treatment is often employed in cases of acute leukemia when other treatments have proven ineffective. Stem cell transplantation can be autologous, using the patient's own stem cells, or allogeneic, involving stem cells from a compatible donor. Allogeneic bone marrow transplants require close donor-recipient matching and are associated with a higher risk of complications but offer a potential cure for specific leukemia types.

Immunotherapy: Immunotherapy is an emerging approach that harnesses the body's immune system to target and eliminate cancer cells. CAR-T cell therapy, a form of immunotherapy, has shown significant promise in treating specific leukemia types, particularly acute lymphoblastic leukemia (ALL). CAR-T cell therapy entails genetically modifying a patient's T cells to recognize and attack leukemia cells. These modified T cells are reintroduced into the patient's body, where they locate and destroy cancer cells. While CAR-T therapy has exhibited remarkable success, it can also lead to severe side effects, including cytokine release syndrome, necessitating careful monitoring and management.

Supportive Care: Effectively managing the side effects and complications of leukemia and its treatments is crucial. Supportive care may involve blood transfusions to address anemia and low platelet counts, antibiotics to prevent infections, and medications to alleviate pain and discomfort.

Patients undergoing leukemia treatment or treatment of other blood disorders, like myeloma or lymphoma, typically require a multidisciplinary approach involving oncologists, hematologists, nurses, and other healthcare professionals. Regular monitoring and adjustments to treatment plans are common practices to ensure the best possible outcomes. You can find some of the best medical specialists and healthcare team in reputed hospitals situated at Delhi.

The cost of leukemia treatment will vary depending on the type of treatment being performed. The cost of bone marrow transplant in Delhi typically varies between INR 8,00,000 to INR 15,00,000.

[mkgtweety]

SUP DIGITAL PEEPS OUT IN THE WEB WORLD!!!! mkgtweety HERE!!!! IN ANOTHER EPISODE OF: "WHAT'S BEEN GOING ON W/ ME IN THE LAST 3 MONTHS", I SIT DOWN ON MY WRAP-AROUND PORCH AND TALK 'BOUT WHAT'S BEEN GOING ON W/ ME AND WHAT HAPPENED SINCE THE LAST 3 MONTHS' UPDATE VID!!!! SUCH AS, WHAT HAPPENED WHEN I WENT 2 MY 3-MONTH DOCTOR'S CHECKUP 4 MY TYPE 2 DIABETES ON AUG. 26, 2024!!!! I ALSO TALK 'BOUT WHAT'S BEEN GOING ON W/ MY MOM AND DAD SINCE THE LAST 3 MONTHS' UPDATE VID I MADE!!!! P.S. THIS IS THE 1st VID I'VE UPLOADED FROM MY NEW PC THAT I GOT FOR X-MAS OF LAST YEAR FROM "CLAUSE"!!!!

SUBSCRIBE IF YOU LIKE WHAT YOU SEE AND WHAT I DO!!!! AND IF YOU REALLY, REALLY LIKE IT HIT THE THUMBS-UP BUTTON!!!!

LINKS 2 MY 1st 2 VIDS I POSTED ON2 THIS CHANNEL: {HOW I GOT MY OTHER/MAIN ACCT: “mkgtweety” SUSPENDED OVER SOMETHING STUPID I DID HERE AT YOUTUBE!!!! PLEASE WATCH THESE VIDS!!!! PART 1 1st THEN PART 2 2nd IT WILL HELP EXPLAIN HOW I GOT MY OTHER OTHER/MAIN ACCT: “mkgtweety” SUSPENDED!!!!}

LINK 2 PART 1: https://www.youtube.com/watch?v=4sBINjtVgj0&feature=youtu.be

LINK 2 PART 2: https://www.youtube.com/watch?v=64XtKJoumRg&feature=youtu.be

I GOT A NEW DIGITAL CAMERA FROM AMAZON, AND I'M HAVING A PROBLEM W/ IT!!!! I'VE POSTED 'BOUT IT ON MY TUMBLR AND ALSO MADE A VID 'BOUT IT ON MY INSTAGRAM!!!! SO, IF U WOULD LIKE 2 HELP ME, HERE ARE THE LINKS WHERE I'VE POSTED THE PROBLEM I'M HAVING:

(YOU CAN LEAVE ME YOUR THOUGHTS IN THE COMMENTS SECTION OF EACH POST!!!! THANX DIGITAL PEEPS!!!!) THE INSTAGRAM VID I MADE 'BOUT IT: https://www.instagram.com/p/C6rNTJzMa8u/

THE TUMBLR POST I MADE 'BOUT IT: https://mkgtweety.tumblr.com/post/750135717707022336/i-have-a-problem-i-hope-u-can-help-me-digital

MY SOCIALS: TUMBLR: {my childcare blog!!!!} https://mkgtweety.tumblr.com/

TWITTER: https://twitter.com/mkgtweety/

INSTAGRAM: https://www.instagram.com/mkgtweety/

PINTEREST: https://www.pinterest.com/mkgtweety/

WATTPAD: https://www.wattpad.com/user/mkgtweety

[biology-geology-beaches-india]

TSRNOSS, p51.