#blood cancer

[mindblowingscience]

The Janus kinase 2 (JAK2) protein mediates signaling from several cytokine receptors in the regulation of hematopoiesis and immune responses. Somatic mutations in human JAK2 lead to constitutive activation and cytokine-independent signaling and underlie several hematological malignancies from myeloproliferative neoplasms (MPN) to acute leukemia and lymphomas. JAK2 contains an active kinase domain and an inactive pseudokinase domain. Interestingly, pathogenic mutations mainly occur in the regulatory pseudokinase domain. Due to its critical pathogenic role, JAK2 has become an important therapeutic target. The four currently approved JAK2 inhibitors relieve symptoms but do not heal the patient or affect survival. These drugs target the highly conserved kinase domain and affect both normal and mutated JAK2 and, due to side effects, carry a black box warning that limits their use in elderly, cardiac and cancer patients. The selective inhibition of pathogenic JAK2 is a key pending goal in drug discovery that requires a precise mechanistic understanding of the regulation of JAK2 activation.

Continue Reading.

[levikra]

I have Acute Lymphoblastic Leukosis aka Blood Cancer

buckle up :D

This post should've been here for sometime now cuz I prefer keeping everyone updated across all the platforms that I use as an artist.

So - Hi! My name is Evein, on 1st of May 2023 I turned 21 and since then, from 5th of May my health decided to pull a quick one on me, propelling the events that currently make me reside at the hospital with an oncology.

It all started with a tonsillitis-like fever, accompanied by furunclosis in three places on my body, a high fever that lasted for 5 days in the first half of May itself and other unpleasant symptoms. It felt weird, I've never had such an intense streak of sicknesses kick my ass like that, but of course - I went to doctors to get checked, the classic blood testings and general examinations and stuff.

That's when on 10th of May my blood test was checked by a dermatologist regarding my furuncle problem and - after some brief moments of her talking with the main doctor at the clinic - I was rushed to the governmential hospital due to the fact that my blood results had... no white blood cells. Literally 1.83 at the accepted range being much higher than that.

Needless to say I was fucking shocked, I've never dealt with the severity of the situation and let alone while being completely on my own as a human person (working, living, providing for myself, you call it).

At the hospital, after several examinations and another blood test came the recommendation paper that doctors signed with urgency, first and foremost I needed to get to an appointment at the hematologist's. That I did on 14th of May and since that point of time, till 19th, I'd been monitored, given antibiotics for my tonsillitis-like symptoms, along with my furunclosis and after 19th we ruled out the condition to be leukosis, became my white blood cells started coming back to normal with the antibiotics aiding my immunity, but despite that - thr condition still seemed as something more reminiscent of mononucleosis (which, however, in another blood test was disproven).

After exactly a week of feeling better, albeit dealing with leftover anemia, I started developing the same symptoms back and even worse, to the point of losing consciousness and thrwoing up in an elevator on 29th of May after going out for the second pack of antibiotics my hematologist had then already approved of to use to help out.

That's when I was rushed to the hospital again and - the next day - my hematologist arranged an appointment at the big clinic that has an oncology ward specifically for my situation. On 1st of June I was officially admitted with Acute Leukosis (the diagnosis doc attached is in Russian).

Since 1st of June the treatment has been ongoing, I've received three rounds of chemo along with supporting hormonal abd antibiotic therapy. Me is balding too, ofc. :D

And thus, this story leads to a logical question - what's now?

It's day 24 of my treatment, out of 4-6 weeks of inital induction period of leukosis' treatment (the overall chemotherapy to destroy tumor cells down to <5% in my bone marrow). After the induction period, if it's proven to lead to remissions - I'm then admitted out to certain periods of time in between infusions + need to take supporting medicine by myself (hence buying it too).

As an independent freelance artist who's existence is tied to being able to do creative work out of, well, any circumstances, I was sadly forced into situation of asking for monetary support, simply because it's stupid to expect to break your own back trying to work harder when you're body is collapsing on itself.

I have a goal on Boosty open for donations and I deeply appreciate ANY and I mean ANY traction of this post. I made a similar thread on Twitter covering the situation and have recieved a lotnof incredible support that has helped me a LOT so far, but my treatment is ongoing, or to be precise - will last in its entirety for 2-3 years. With the momentary help I was able to secure my living situation and get my pet cat to live for the current time period at my friend's, but you understand how that is just a temporary measure and, of course, I don't plan on stall myself - I simply just can't afford that even while hospitalised.

BOOSTY is very sus when it comes to singular donations higher than 120$ but if you happen to donate below that or in several different ones to bypass their antifraud system (only if you wish to) - the link to a goal is here -

[bpod-bpod]

Essential for Marrow

Activity of a gene called LATS2 in the bone marrow's blood vessel cells is shown to be vital for normal functioning of the bone marrow, its loss leads to fibrosis – providing greater understanding of diseases such as leukaemia

Read the published research article here

Image from work by Kishor K. Sivaraj and Paul-Georg Majev, and colleagues

Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Cardiovascular Research, July 2024

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[millenniallust4death]

Multiple Myeloma March: Week 3 Update

I haven't updated about the Multiple Myeloma March in a bit so here's a short recap of how we are doing. Here's a link to my original post.

By the Numbers:

Total Donations: $1,522!

Ranking: #7 in the Top Ten Fundraisers

Steps Taken: 140,475 of 200K in sweltering Wheatley (70% done!)

News: I asked if we could join the Windsor-Essex March team so that our donations will used to support a specific Multiple Myeloma project at the University of Windsor. Dr. Lisa Porter's project is titled, "Establishing a Multiple Myeloma Drug Screening Platform to Predict Patient Response to Therapy". I'll share more information about the project in a future post. (The University of Windsor is my local university.) I think universities partnering with Myeloma Canada and local March teams is a really neat idea.

Thank you to everyone for so generously supporting us! We really appreciate it. Martin postcards are in the mail so you have something small to look forward to!

Donate: Here's the donation link if you would like to support us (and feel you can afford to do so).

[fooltemps]

Leukemia and Lymphoma Awareness Flags!!

This flag was designed by us, as we currently have a family member with Leukemia and wish to bring awareness to this kind of cancer.

color meaning:

#FF2D34: Myeloma

#00DC0E: Non-Hodgkin Lymphoma

#FF8C2E: Leukemia

#D12DFF: Hodgkin Lymphoma

Below is information all about Leukemia and Lymphoma Cancers.

Leukemia and Lymphoma are both cancers that are not associated with a tumor. Lymphomas are cancers that affect the lymph system and start in cells called lymphocytes. Leukemia is a cancer of the early blood-forming tissues, including your bone marrow and lymph system.

There are many types of lymphoma. Some grow and spread slowly and some are more aggressive. There are two main types of Lymphoma:

1. Hodgkin Lymphoma is cancer that starts in the B lymphocytes (B cells) of the lymph system. Your lymph system helps you fight infection and control the fluids in your body.

2. Non-Hodgkin Lymphoma (NHL) is cancer that starts in the lymphocytes anywhere lymph tissue is found:

Lymph nodes

Spleen

Bone marrow

Thymus

Adenoids and tonsils, or

The digestive track.

Leukemia typically involves white blood cells, the cells that are your infection fighters. Leukemia can be divided into categories: fast growing (acute) and slow growing (chronic); and by which white blood cells are affected:

Acute lymphocytic leukemia (ALL)

Acute myelogenous leukemia (AML)

Chronic lymphocytic leukemia (CLL

Chronic myelogenous leukemia (CML)

A screening test is used to detect cancers in people who may be at higher risk for developing the disease. With leukemia and lymphoma, there are no early detection tests. The best way to find them is to be aware of the symptoms:

Swollen lymph nodes which can appear as a lump in the neck, armpit or groin;

Fever

Night sweats

Weight loss without trying, and

Fatigue.

Leukemia can have similar symptoms but also can include:

Easy bleeding or bruising;

Recurring nosebleeds; and

Bone pain or tenderness

Myeloma is cancer of the plasma cells. Plasma cells are white blood cells that produce disease- and infection-fighting antibodies in your body. Myeloma cells prevent the normal production of antibodies, leaving your body's immune system weakened and susceptible to infection. The multiplication of myeloma cells also interferes with the normal production and function of red and white blood cells. An abnormally high amount of these dysfunctional antibodies in the bloodstream can cause kidney damage. Additionally, the myeloma cells commonly produce substances that cause bone destruction, leading to bone pain and/or fractures.

Myeloma cells are produced in the bone marrow, the soft tissue inside your bones. Sometimes myeloma cells will travel through your blood stream and collect in other bones in your body. Because myeloma frequently occurs at many sites in the bone marrow, it is often referred to as multiple myeloma.

Signs and symptoms of myeloma include the following:

Hypercalcemia (excessive calcium in the blood)

Anemia (shortage or reduced function of red blood cells)

Renal damage (kidney failure)

Susceptibility to infection

Osteoporosis, bone pain, bone swelling, or fracture

High protein levels in the blood and/or urine

Weight loss

In 2022, more than 62,650 people are expected to be diagnosed with leukemia. In addition:

Leukemia accounts for 3.6% of all new cancer cases.

The overall 5-year survival rate for leukemia has more than quadrupled since 1960.

62.7% of leukemia patients survive 5 years or more.

The diagnosis of leukemia requires specific blood tests, including an examination of cells in the blood and marrow.

Treatment and prognosis depend on the type of blood cell affected and whether the leukemia is acute or chronic. Chemotherapy and blood and marrow transplant are often used to treat leukemia.

If you wish to read more about Leukemia and Lymphoma cancer, please visit this website!

[canadiankazz]

Hi everyone! I'm taking part in The World's Greatest Shave this year. On September 28, I'm going to shave my head to help raise money for the Leukeamia Foundation. If you are able to donate, it would be greatly appreciated!

(You may share this page)

Thank you!

[thisiswhatafighterlookslike]

The Pressure To Be Brave

"You Are So Brave!" How often have we heard this said to us? Most times, people truly mean well when they say this. They are doing their best to be encouraging from their perspective of things. However, for many of us who are surviving cancer daily, those four words are filled with so much pressure and expectation.

When people see us maintaining our lives, managing families, enduring all the craziness that comes with living with this disease, they see bravery! Well, there is truth to that. But the real truth is we are just giving our all to live every day and live our best! It takes a lot of work just to maintain our "normal" lives.

Am I a superhero?

Indeed, we are strong and courageous. We fight uncommon battles for our lives absolutely every day. However, knowing that people can see you as this 'cancer superhero' and being given this subconscious permission to be brave, #BeatCancer, #KickCancersButt, #FightLikeAGirl, and all the other awesome hashtags can be overwhelming!

We didn't choose this fight

We definitely appreciate the love and encouragement! But the reality is that some days we are just SICK! There is nothing we can do about it and to be honest, we don't even have the energy to do anything. We get weak. Not tired but fatigued; downright exhausted! We have mood swings. We battle depression and sometimes it actually fights back...and wins! LOL!!!!

We deal with feeling isolated and alone. We are oftentimes in pain. We are in agony, and it doesn't always go away. Some of us live in pain. We lose weight and we gain weight! We lose our hair, our precious hair! Until you have experienced this, you just have no idea what this does to someone. We think about our mortality more times than the average person does.

Tell me it's going to be okay!

So, it's not that we don't want to be told we are brave. Here is the thing, we know living with cancer requires a special measure of bravery. We know we are brave. But it would mean so much more if we heard, "It's going to be okay", "it's ok to feel how you are feeling", or "no matter how you feel today, I will be here to help and support you!"

Our loved ones believe they keep us strong by coaching us through this and pushing us. If they just speak positively and keep us thinking about how we "should" think then we will feel and live how we are supposed to. Please remember we are human beings with real feelings, who happen to be surviving cancer daily. Just let us be that that's how we are Brave!

Leya R. Elijah

This Is What a Fighter Looks Like

CEO/Founder

[mak-and-chill]

Join the fight against blood cancer!

I am participating in The Leukemia & Lymphoma Society's (LLS) Student Visionaries of the Year campaign to raise money and awareness for blood cancer patients & their families. 

Our campaign is coming close to an end so PLEASE consider donating! Even just a dollar is greatly appreciated!

My fundraising page link: https://events.lls.org/ga/svoyaugust24/MDowd

Thank you for your support!

[bloodcanceruncensored]

Market Research on Car T Therapy--a paid study for USA residents from Health Union

This opportunity was sent to us by our friends at Social Health Network Blood-Cancer.com is conducting a market research study on behalf of a sponsor, to understand the treatment experiences of blood cancer patients who have received or discussed CAR T therapy. If you complete the screening survey and qualify for the study, you may be asked to participate in a 30-minute interview, which would be…

[nalyra-dreaming]

re: yesterday's ask about drinking blood of the sick people. I always saw it as blood cancer being a very specific disease which affects blood cells directly. Gabrielle was dying from tuberculosis, so her problem was in her lungs, not her blood. And I don't remember vampires drinking blood of people with leukemia in the books, and effect of it on them.

True, though Lestat also fed on old, sick people (for example) and iirc the books don’t really make a distinction. It stands to reason the would encounter this before, though of course Anne didn’t need to explicitly note it in the stories.

As @lioncunt has added correctly the poison Claudia used in the books was to keep the blood warm, not to have the poisoning effect on Lestat.

But… I personally like the adaption/evolution they made from the book canon ability to get drunk on people who are (wine/beer) drunk, and which is on display with the wine cellar and the bottles laying around in ep 5 in the show. Because I think they twisted that into an interesting lore update for drugs and other substances, since it is also canon in later books that infusions/hormones do work after all.

But yeah, blood cancer probably … tastes real bad to them 😅

[impomed]

Navigating the world of cancer treatments can be overwhelming, but this guide simplifies the process of accessing effective therapies. With advanced options like Ponatinib Tablets in India, patients have new hope for managing complex conditions like leukemia. Understanding affordability and availability is crucial for patients seeking optimal care. Impomed Healthcare is committed to providing high-quality solutions, ensuring accessibility without compromising on quality. By empowering patients with the right knowledge and resources, this guide highlights essential steps to secure life-changing treatments. Trust in reliable partners to make your healthcare journey more manageable and impactful. For more information visit : https://www.impomedhealthcare.com/

[hersheysmcboom]

Please help save his life, become a donor today

[bpod-bpod]

In a Bind

Multiple myeloma is a blood cancer affecting plasma cells, white blood cells that produce antibodies, causing them to multiply abnormally in the bone marrow. Right now, only half of patients can expect to survive five years after diagnosis, so better treatments are sorely needed. Promising targets include fatty acid-binding proteins (FABPs), a multi-functional family of proteins that can pick up lipids, involved in a variety of processes. A recent study found that cultured myeloma cells (pictured, their nuclei in blue) expressed high levels of one member in particular, FABP5 (in red); blocking it reduced cell proliferation, while patients with higher FABP5 levels tended to experience worse outcomes. Inhibiting FABPs more broadly appeared even more effective, improving survival in some mice with myeloma. To build on these results, further research needs to investigate why not all mice responded so well, and whether inhibiting FABPs would be safe and effective in humans.

Written by Emmanuelle Briolat

Image from work by Mariah Farrell and colleagues

Center for Molecular Medicine, Maine Health Institute for Research, Scarborough, ME, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, March 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[drpawankumarsingh]

Transforming Care: Peripheral Blood Stem Cell Transplant

Peripheral Blood Stem Cell Transplant (PBSCT) is an advanced medical procedure offering new hope to people with severe blood diseases, cancers, and immune system disorders. It is a less painful and more effective alternative to traditional bone marrow transplants, providing better outcomes for patients. To ensure the best care, consult the Best Hematologist in Noida and book a Hematologist Appointment for expert advice. Read more: https://medium.com/@drpawankumarsingh8/transforming-care-peripheral-blood-stem-cell-transplant-3ac3d8352b06

[fooltemps]

Leukemia and Lymphoma Awareness Userboxes!!

free to use by anyone! credit not needed but appreciated

leukemia flag here!

[harshamitra]

What are the common early symptoms of blood cancer?

Common Early Symptoms of Blood Cancer

Blood cancer, encompassing leukemia, lymphoma, and myeloma, often manifests with symptoms that may initially seem mild or unrelated. Recognizing these early signs is crucial for timely diagnosis and effective treatment. Here are the common early symptoms to watch for:

Fatigue and Weakness: Persistent tiredness or feeling drained despite adequate rest.

Frequent Infections: A weakened immune system can lead to recurring or prolonged infections.

Unexplained Fever: Persistent or intermittent fever without an obvious cause.

Easy Bruising and Bleeding: Increased tendency to bruise or bleed, such as nosebleeds or gum bleeding.

Swollen Lymph Nodes: Painless swelling in areas like the neck, armpits, or groin.

Bone or Joint Pain: Discomfort or pain, particularly in the back or long bones.

Night Sweats: Excessive sweating during sleep, often drenching bedclothes.

Weight Loss: Unintended and unexplained weight loss over a short period.

Pale Skin and Breathlessness: Signs of anemia due to reduced red blood cell count.

At Harsha Mitra Hospital, a leading cancer hospital in Trichy, our team of experts emphasizes early detection for better outcomes. Blood tests, imaging, and biopsies are utilized to diagnose blood cancer and determine the best treatment plan.

If you or a loved one experience these symptoms, consult a healthcare professional promptly. Early intervention can make a significant difference in managing blood cancer effectively.