#mmp-3

[immunobuffoono]

The VECTRA Blood Panel

*Scroll to the bottom portion of this post to view my test results...

PSA: If you are struggling with a mystery illness and cannot find the "right" medical specialists, I do formally recommend making a request to your most trusted physician about a blood serum/plasma panel known as "VECTRA." Testing individual inflammatory markers like C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) will inform you about potential inflammation underway in your body, but VECTRA is far more comprehensive & can give you insight into your disease activity as compared to a large population of patients with diagnosed rheumatoid arthritis.

[Sort of Unnecessary Side Quest: HAVING A NEGATIVE ANA RESULT IS NOT A REASON FOR A PHYSICIAN'S DISMISSAL! Personally, I have consistently tested negative on ANA panels, and after 20 years of this horseshit, that god awful test is the sole reason for being dismissed by many, many specialists time and time and time and time and time again... A negative ANA alongside positive inflammatory markers (like CRP & ESR) is termed "seronegative." Seronegative autoimmune diseases, although far less common, are absolutely real and deserve the same attention from physicians as the more common, seropositive autoimmune diseases. VECTRA can help prove your pain is valid and needs treatment, especially in the face of a consistently negative ANA!]

VECTRA Panel Pros/Cons (& What It Can Do For You)

What it definitely means/can do to help expedite the diagnostic process:

Measures RA disease activity: VECTRA provides an objective score reflecting the level of inflammation and joint damage that is suspected to occur without appropriate and prompt treatment.

Monitors treatment response: Helps doctors determine whether a patient's RA treatment is working or if adjustments are needed.

Assesses risk of joint damage: Higher scores are associated with increased risk of progressive joint damage.

Incorporates multiple biomarkers: The test evaluates 12 proteins associated with inflammation and immune activation, offering a more comprehensive look at disease activity compared to single-marker tests (e.g., CRP alone).

What it could mean but is not definitive without further testing:

Could indicate active inflammation: A high VECTRA score suggests ongoing inflammation, but it does not pinpoint the exact cause. Additional testing is needed to determine if another condition (e.g., chronic infection, another autoimmune disease with similar features, certain types of cancer, etc.) is contributing.

Could correlate with other inflammatory conditions: While designed for RA, some biomarkers in the test can be elevated due to other inflammatory or autoimmune diseases.

Does not confirm or rule out RA: A high or low VECTRA score alone does not diagnose or exclude rheumatoid arthritis—other clinical criteria and tests (ANA, RF, Anti-CCP, Tissue Imaging, Gene Mutation Analysis, etc.) are required for a diagnosis.

What it does not mean/can't tell you/can't do for you:

Not Covered by All Insurances: VECTRA is a Labcorp-owned blood panel. Unfortunately, this privatization of services does mean that VECTRA may not be covered by certain health insurance plans. Be sure to check with your insurance company first before moving forward with testing.

Does not diagnose RA: VECTRA is a disease activity test, not a diagnostic test for rheumatoid arthritis specifically.

Does not differentiate between different autoimmune diseases: Elevated markers may suggest inflammation, but they do not confirm RA specifically. The test simply compares your disease activity with approximately 300,000 patients definitively diagnosed with RA and can help define the severity of the disease activity in your body.

Not useful for all RA patients: Some people, particularly those with low CRP levels or seronegative RA, may not get reliable results from this test.

Not a replacement for imaging or clinical assessment: While VECTRA provides valuable biomarker data, physical exams, imaging (X-rays, MRIs), and other lab tests remain essential for evaluating RA progression.

My VECTRA Blood Panel Results

What My Results Definitely Mean For Me:

My Vectra DA Score is 45, which falls into the high disease activity category.

A high Vectra score indicates that I have some sort of disease underway that is highly active & that correlates with an increased risk of radiographic progression (observable joint damage/erosion). In other words, I am dealing with a chronic, observable disease which is causing severe & ongoing damage to my body - resulting in multi-system organ involvement and an array of primary diagnoses that may rather be secondary comorbidities of my unnamed systemic illness instead. AKA it means I'm sick AF you guys. Literally all the time. For 20 fucking years straight.

My 1-year risk of radiographic progression is 7%, suggesting a predictable joint damage progression within the coming year if left untreated or mismanaged.

My highest inflammatory marker percentile result listed was EGF (Epidermal Growth Factor), which showed that, compared to the tested RA patients, I am in the >99th percentile for this inflammatory marker. This essentially means that, if continued to be left unmanaged, the progression of this disease could result in irreparable joint and tissue damage. [These higher percentile scores typically display which disease pathway that needs to be targeted in order to treat the condition.] (Example: Biologics that treat diseases like Crohn's often target Interleukin 6, an inflammatory cytokine that, for me, has always tested within the normal range. Long story short, this VECTRA panel helps pinpoint possibilities for treatment potentially [despite maybe never being able to give this a formal name], but due to the complexity of my case, we still have a long way to go and lots more tests to undergo before this gal could potentially see any sort of remission.)

Other Resources

"A Guide to Your VECTRA Molecular Result" as Published by Labcorp for Patients

"Guiding Rheumatoid Arthritis Treatment Decisions" (with regard to VECTRA results) as published by Labcorp for Patients

"Rheumatoid Arthritis Comprehensive Testing Capabilities" as Published by Labcorp for Patients

[yj-98]

quick panel redraw of one of my fave silly tim moments for his birthday <3

[lavieestbelle]

M.M.P – Notre #Centre

M.M.P – Notre Centre https://markenmarcproduction.art.blog/notre-centre/

Notre Centre

[ur-local-flesh-hive]

What do worms eat.

The one in my jar keeps crying I think it's anemic and I don't know how to nourish it

NNO OO O ! !! : (( pp oor b abb yyy . ..

ppe rr sso nna lly i ffi nnd mmy chh i lld rre nn llo vve hhu mma nn ffll e ssh <<3 bbu tt whh a tte vve rr cco mmp oss tt yy ouu hha vve in tth e hh ouss e iss ppe rrf ecc ttl y add eqq uaa tte :)

[khaoala]

Oh, so we probably won't get much content from khao other than THK fanmeetings this first half of the year?? Cause since first is starting to film MMP real soon, he probably has secured at least 3 months of work + the promotions when the series airs. And we won't have solo events for khao since he doesn't have anything to promote.

not necessarily, i don't think. we gotta remember that first's role in mmp is a secondary one. yes, he's the antagonist, but from what i understood from the pilot trailer, a great part of the story happens in the countryside with jimmysea's characters hiding together, so i don't think first has 3 months of work. he might come and go for a few qs similarly to how it was with pepper and kenji in thk (but he will most likely promote the show, we'll just have to wait and see how much. during thk for example, they didn't necessarily have that many more events).

and not having anything to promote doesn't necessarily mean not having events, either. events in the fkt fandom are already fewer if compared to some other couples, but in 2024, firstkhao didn't have anything to promote until later in the year, but they still had some events to attend. honestly, it's just a wait and see game. they have other things to focus on (like i mentioned, kt was planning on graduating if i'm not mistaken), so if it happens, we cheer.

[poyoofthestars]

We are back with more shirts!! -Mod

Dialogues:

1. TC and PV Pecharunt Kirbrunt's assistant: Kieranrunt

(Time in shirt: 24 hours)

TC: One day you’ll be in here without me

PV: We’ll see

Kieranrunt: Now folks, they're the problem

Kirbrunt: Agreed

2. Marx and Bandana Dee Kirbrunt's assistant: Magolor

(Time in shirt: unknown)

Bandana: You little piece of-! You're the reason why I'm here!!

Marx: (not listening and thinks,) I can't stand Mags.

Magolor, on the side: (thinking) Enjoy your extended period, Marx

3. Dedede and Dark Matter (Taranza) Kirbrunt's assistant: Gooey

(Time in shirt: 24 hours)

Dedede: STAY AWAY FROM ME, YOU CREEP!!!

DM(T): But I'm your husband

Dedede: Gross!

Gooey, unaware of the arguing behind him: Get along you two

4. Taranza and Dark Meta Knight Kirbrunt's assistant: Void

(Time in shirt: 48 hours)

Taranza: One of these days, I'm gonna get rid of you

Dark, who duct tape over his mouth: Mmph mmp mmph (The feeling is mutual)

Void: Remove the tape and the time is extended

5. TC Pecharunt and Marx Kirbunt's assistant: PV Pecharunt, everyone in the Star Allies

(Time in shirt: unknown)

PV, dying of laughter on the floor: Hahaha! Oh my Original One! This is ridiculous! Who's in the shirt now, huh?

TC: Shut up

Marx: Nice friendship, peachy

TC: You shut up

Marx: Shut up, shmarsh up

6. TC and PV Kieran Kirbrunt's assistant: Kieranrunt

TC Kieran: I know we both want to get stronger, but your annoying.

PV Kieran: Shut up, arsewhole

TC Pecharunt: How?

PV Pecharunt: ...why?

------------------------------------------------------------------------------

Kirbrunt and Kieranrunt: That's all folks!

credits~~

TC Pecharunt, TC Kieran - @tealmaskmybeloved/ @the-boy-and-the-poison-puppeteer

PV Pecharunt, PV Kieran - @milliemuus

Kieranrunt - @marisol124

Dark Matter Taranza - @usps-first-class

[changoblanco]

Did you know there is a #playboymagazine in #madmonsterparty ? I didn’t until I was pulling stills of the sets. In Kronkite Pharmacy. Mr. Kronkite refers to a custom browsing through the paperback books and it cuts to this shot of a man at a magazine rack, and there, frame right are 3 tiny issues of the March 1964 Playboy magazine featuring covergirl Olga Schoberova. What? How? I know Harvey Kurtzman, who co-wrote the MMP script also had worked for Playboy and created Little Annie Fanny. It’s interesting to me how the few magazines chosen are from such different dates. If you swipe you will see I’ve identified others magazine issues that appear but none are as exciting as the Playboy. The others are (oddly no mad magazine) #TimeMagazine Jan 1966 Indira Gandhi , #saturdayeveningpost April 1965, Movie Life #barbaraparkins December 1955 #photoplay #jackiekennedy Oct 1965, #seventeenmagazine June 1958 #lifemagazine Oct 1965.

[not-jiraikasa-kun]

Yayyyayay o(^▽^)o

Can’t put gifs in sob… but dog spinning gif :3

-scruffy

YAYAYAYA

also!!! Catches you and hugssss pupy…

mmp. Cute doggy :3

[healthhaircolor]

Sun exposure – UV radiations trigger the process of photoaging.

Disturbance in the equilibrium status of oxidants & antioxidant defense system.

Increased levels of oxidative Stress.

Increased MMP-1 and MMP-3 which causes degradation of collagen fibers.

Disturbed levels of antioxidants like L-Glutathione stimulating photoaging & hyperpigmentation.

[lilywily143]

for the number thing 3

3. Drunk kiss

Okay :]

A little suggestive

Riley: How did you get drunk on oil? How much did you ki- MMP!

Thad: There~ You were heating up

[1ckydoggy]

I loveeeeeeee being high and floaty it’s sooooo nice :3 mmp

[etes-secrecy-post]

Hi, before I explain my post, I want to say something important.

• What you see my blog has become a major overhaul. And despite the changes, I decided that my 2nd account will be now my artwork blog with a secret twist.

⚠️NEW RULE! (W/ BIGGER TEXT!)⚠️

⚠️ SO PLEASE DO NOT SHARE MY 2nd ACCOUNT TO EVERYONE! THIS SECRECY BLOG OF MINE IS FOR CLOSES FRIENDS ONLY!⚠️

• AND FOR MY CLOSES FRIENDS, DON’T REBLOG IT. INSTEAD, JUST COPY MY LINK AND PASTE IT ON YOUR TUMBLR POST! JUST BE SURE THE IMAGE WILL BE REMOVED AND THE ONLY LEFT WAS THE TEXT.

⚠️ SHARING LINKS, LIKE POSTS, REBLOG POSTS, STEALING MY SNAPSHOT PHOTOS/RECORDED VIDEOS/ARTWORKS (a.k.a. ART THIEVES) OR PLAGIARIZING FROM UNKNOWN TUMBLR STRANGERS WILL IMMEDIATELY BE BLOCKED, RIGHT AWAY!⚠️

😡 WHATEVER YOU DO, DO NOT EVER LIKED & REBLOG MY SECRET POST! THIS IS FOR MY SECRET FRIENDS ONLY, NOT YOU! 😡

Okay? Capiche? Make sense? Good, now back to the post…↓

#Onthisday: Sept 6th, 2018

Title: Cuteness Member - Xtianz

Here's another HTF OC to be joined, Xtianz and his suited Zeon Armor the armored "Zaku II Kai"! 🙂

Zaku II Kai Xtianz Came from the real: MS-06FZ Zaku II Kai

Armament(s):

• 3-slot Grenade Rack Stored on the right hip of the Zaku for convenient access are three hand grenades. The Zaku Kai's grenades were more compact than the "cracker" grenades used by the original Zaku. While not very powerful or accurate, they're capable of performing different roles in the battle.

• Shoulder Shield The shield is a simple defense used to block most incoming ballistic and explosive projectiles. Also used to great effect in close quarters battle with enemy mobile suits. The Zaku II Kai mounts a shield on its right shoulder.

• MMP-80 90mm Machine Gun The upgraded version of the MMP-78 120mm Machine Gun. It used 90mm bullets instead of 120mm type, allowing for a greater speed of firing and a higher rate of penetration. The machine gun is magazine-fed with 32 rounds per mag. The MMP-80 was also integrated with a grenade launcher under its barrel for more firepower.

• Grenade Launcher The MMP-80 is fitted with an underslung grenade launcher. The grenade wasn't very effective against large ships, but was an ideal mid-range anti-mobile suit weapon.

• 120mm Machine Gun The 120mm machine gun is a standard weapon for Zaku type mobile suits. It is a shell firing gun that does not require energy to be used, however its effectiveness against heavy armor is very limited. It holds 100 rounds per drum with spare drums that can be stored on waist armor racks.

• Heat Hawk An axe-shaped close combat weapon, it uses a super-heated blade to cut through the armor of enemies and/or vehicles. The thermal energy is generated by the power output of the Zaku II's thermonuclear reactor and relayed through the armored hands. The Heat Hawk used by Zaku II Kai is modified with an extendable handle for longer reach in close quarter combat.

• Heat Sword A melee weapon originally developed for the Gouf line of mobile suits. Like the Zaku's heat tomahawk the heat sword is a blade that is heated to high temperatures in order to increase it's cutting capacity. The Heat Sword was designed after a broadsword so its blade is longer than the tomahawk allowing for a greater range of attack.

• H&L-SB25K/280mmA-P Zaku Bazooka The 280mm Zaku Bazooka was another standard weapon that could be equipped to a Zaku type mobile suit. The bazooka fired explosive rounds that were quite effective against the armor of Earth Federation mobile suits and battleships.

• Sturm Faust An explosive weapon with a rocket propelled warhead, it was designed before the beginning of the One Year War as an anti-ship weapon. Useful both in space and under gravity, it was mainly deployed for anti-ship attacks. The Sturm Faust likely made a good anti-armor suit weapon, could be equipped with both a Sturm Faust and a more typical ranged weapon for greater versatility. As a non-guided weapon, it is difficult to hit targets with high mobility.

• Shield The shield is a thick sheet of armor designed to take severe punishment that would normally destroy a mobile suit. Since the introduction of beam weaponry, shields have been treated with an anti-beam coating allowing it to withstand several beam shots before the coating wears off. Typically physical shields can only take so much damage before they succumb to the pressure and break.

Special Equipment(s) / Feature(s):

• Zaku II Kai's Mask An exact replica of the original Zaku II Kai head and a special optional accessory that can be worn on his/her face. With built in signature mono-eye w/ all feature needs, like night vision, smart target detector, a snorkel prevents all sorts of harmful smoke/gas and good used for underwater diving surface, etc...

Xtianz (HTF OC) - owned by Xtianzarts (dA) Armor (Mobile Suit Gundam 0080: War in the Pocket) - Gundam Series © SUNRISE, Sotsu

[musicmattersproductionsus]

Why IP-Rated Gear is Essential for Outdoor Events

Outdoor events come with a long list of variables — weather being the biggest wildcard. Rain, dust, extreme heat, or unexpected downpours can turn a smooth production into a logistical nightmare if you’re not prepared. That’s where IP-rated gear comes in.

At Music Matters Productions (MMP), we believe that no element should stand in the way of delivering an event. Our IP-rated lighting, audio, and video equipment ensures that productions run seamlessly, no matter what the forecast throws our way.

What is IP-Rated Equipment?

IP (Ingress Protection) ratings classify how well equipment is protected against solids (like dust) and liquids (like rain). The higher the rating, the better the protection — which means less downtime, fewer failures, and more confidence in outdoor environments.

Why IP-Rated Gear Matters for Outdoor Productions

1. Weather-Proof Performance

Rain or shine, the show must go on. IP-rated fixtures and audio gear ensure consistent performance, eliminating the risk of malfunctions due to moisture or extreme conditions. No more scrambling for last-minute cover or worrying about costly damage.

2. Less Equipment Downtime

Unprotected gear means more time troubleshooting and replacing damaged components. IP-rated gear reduces maintenance needs and failure rates, keeping production running smoothly from load-in to load-out.

3. Safer, More Reliable Events

Wet cables, exposed electronics, and unpredictable weather don’t mix. IP-rated gear minimizes safety risks by preventing electrical hazards and ensuring all equipment stays operational — even in tough conditions.

This blog is originally published here: https://musicmattersproductions.com/why-ip-rated-gear-is-essential-for-outdoor-events/

[pothame]

i have 3 canon mmp urls for the first time ever im so seated for this show. they tried to make me leave bc “filming isn’t even done yet” but they can’t because im so seated

[renatoferreiradasilva]

PROJETO DE PESQUISA PARA O SUS

Desenvolvimento de um Sistema Integrado de Diagnóstico Precoce do Câncer Baseado em Compostos Orgânicos Voláteis (VOCs) e Aprendizado de Máquina

Área Temática: Ciências da Saúde / Tecnologia Biomédica / Inteligência Artificial

Duração: 36 meses

1. RESUMO

Este projeto propõe o desenvolvimento de um sistema integrado de diagnóstico precoce do câncer, combinando análise de compostos orgânicos voláteis (VOCs) exalados na respiração e biomarcadores em fluidos biológicos (sangue/saliva). O sistema será baseado em modelagem matemática da difusão de VOCs, sensores portáteis e aprendizado de máquina, permitindo uma abordagem não invasiva e de baixo custo para detecção de câncer em estágios iniciais.

Metodologia: O estudo será realizado em três fases: (1) modelagem computacional e geração de dados sintéticos; (2) desenvolvimento de sensores biomédicos para VOCs e biomarcadores; e (3) validação clínica em parceria com hospitais do SUS.

Resultados esperados: Criação de um dispositivo portátil validado clinicamente com precisão superior a 95%, tornando o diagnóstico precoce mais acessível no SUS.

2. OBJETIVOS

Objetivo Geral

Desenvolver e validar um sistema portátil de diagnóstico precoce do câncer, utilizando análise de VOCs, biomarcadores e aprendizado de máquina, com foco na aplicação no SUS.

Objetivos Específicos

Validar a relação entre VOCs, Cu⁺ e progressão tumoral por meio de modelagem matemática e dados clínicos.

Desenvolver um sensor portátil para detecção de VOCs e biomarcadores em sangue/saliva, baseado em nanotecnologia.

Implementar algoritmos de aprendizado de máquina para classificação de tumores.

Realizar ensaios clínicos com 1.000 pacientes do SUS para testar a viabilidade do dispositivo.

3. JUSTIFICATIVA

O câncer é a segunda principal causa de morte no Brasil, com >700 mil novos casos/ano (INCA, 2023).

Desafios dos métodos atuais: exames são caros, invasivos e têm baixa acessibilidade.

Novas abordagens:

VOCs exalados refletem alterações metabólicas do câncer (Zhang et al., 2024).

Cu⁺ influencia metaloproteinases (MMPs) associadas ao crescimento tumoral (Silva et al., 2023).

DIFERENCIAIS DO PROJETO: ✅ Modelagem matemática avançada → difusão anômala de VOCs com equações diferenciais fracionárias. ✅ Sensores de baixo custo → nanotecnologia aplicada ao SUS. ✅ Validação clínica com população brasileira → considerando fatores genéticos e ambientais.

4. METODOLOGIA

Fase 1: Modelagem Computacional e IA (Meses 1-12)

📌 Objetivo: Criar um modelo matemático da difusão de VOCs e treinar modelos de IA para previsão de câncer.

🔹 Modelagem da Difusão de VOCs

Uso de equações diferenciais fracionárias (Caputo) para simular a dispersão de VOCs.

Integração de parâmetros como concentração de Cu⁺ e atividade de MMPs.

📌 Código: Modelo de Difusão Fracionária

import numpy as np from scipy.special import gamma def grunwald_letnikov_diffusion(u, beta, dx): """Modelo de difusão fracionária usando Grünwald-Letnikov""" n = len(u) coeffs = [(-1)**k * gamma(beta + 1) / (gamma(k + 1) * gamma(beta - k + 1)) for k in range(n)] return np.convolve(u, coeffs, mode='same') * dx**(-beta)

🔹 Geração de Dados Sintéticos

Simulação de níveis de Cu⁺, VOCs e atividade de MMPs para criar um dataset inicial.

🔹 Treinamento de Modelos de Aprendizado de Máquina

Implementação de XGBoost e Redes Neurais para análise de padrões nos VOCs.

📌 Código: Modelo de IA para Classificação de Câncer

import xgboost as xgb from sklearn.model_selection import train_test_split from sklearn.metrics import classification_report X_train, X_test, y_train, y_test = train_test_split(data, labels, test_size=0.2, random_state=42) model = xgb.XGBClassifier(n_estimators=100, max_depth=5, learning_rate=0.1) model.fit(X_train, y_train) y_pred = model.predict(X_test) print(classification_report(y_test, y_pred))

Fase 2: Desenvolvimento do Sensor Biomédico (Meses 13-24)

📌 Objetivo: Criar um dispositivo portátil para detectar VOCs e biomarcadores.

🔹 Sensor de VOCs:

Tecnologia baseada em óxidos metálicos e nanopartículas de grafeno.

Capaz de detectar aldeídos e cetonas exaladas pelo paciente.

🔹 Sensor de Biomarcadores:

Uso de aptâmeros fluorescentes para detecção de Cu⁺ em saliva.

🔹 Aplicativo Móvel:

Coleta de dados do sensor e análise via IA em tempo real.

Fase 3: Validação Clínica (Meses 25-36)

📌 Objetivo: Testar o dispositivo em 1.000 pacientes do SUS.

📌 Protocolo Clínico: ✔ 500 pacientes com câncer, 500 controles saudáveis (Hospital das Clínicas de SP e ICESP). ✔ Coleta de respiração, saliva e sangue para análise comparativa com exames padrão-ouro. ✔ Avaliação de métricas: Sensibilidade, especificidade, AUC-ROC.

5. RESULTADOS ESPERADOS

✔ Modelo computacional validado → Difusão de VOCs correlacionada com Cu⁺ e atividade tumoral. ✔ Dispositivo portátil validado → Sensibilidade >95% na detecção de câncer. ✔ Banco de dados público de VOCs e biomarcadores. ✔ Publicação de 3 artigos científicos e registro de patente.

6. ORÇAMENTO DETALHADO (R$)

ItemCusto (R$) Bolsas (2 pós-docs, 4 mestrandos) 1.200.000 Equipamentos (espectrômetro, sensores) 800.000 Materiais (reagentes, eletrônicos) 400.000 Validação clínica (coleta de amostras) 600.000 Publicações / Patente 200.000 Total3.200.000

7. CONCLUSÃO E PRÓXIMOS PASSOS

Este projeto propõe um avanço significativo no diagnóstico precoce do câncer no SUS, tornando-o mais acessível e eficiente. A validação clínica garantirá a confiabilidade da tecnologia, preparando o caminho para sua implementação nacional.

📌 Próximos Passos: ✔ Parceria com hospitais e startups biomédicas. ✔ Testes clínicos ampliados para maior validação. ✔ Registro de patente e publicação de resultados.

🚀 Este projeto pode transformar o diagnóstico do câncer no Brasil!

[not-jiraikasa-kun]

Babykasaaaa!! Hi o(^▽^)o

Gently baps your head…

-scruffy

WAHHH DOGGYY!!!

mmp. Hai doggy :3

bap you back!!!