#hypoxia

[mindblowingscience]

Humans are not yet done cooking. We're continuing to evolve and adjust to the world around us, the records of our adaptations written in our bodies. We know that there are some environments that can make us unwell. Mountain climbers often succumb to altitude sickness – the body's reaction to a significant drop in atmospheric pressure, which means less oxygen is taken in with each breath. And yet, in high altitudes on the Tibetan Plateau, where oxygen levels in the air people breathe are notably lower than lower altitudes, human communities thrive.

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[bpod-bpod]

Click & Detect

Click3D: a method using click chemistry (a class of reactions that make molecules observable) that achieves high-resolution 3D fluorescence imaging of whole organs at unprecedented depth – for example, imaging hypoxia (inadequate tissue oxygen) in a tumour (as shown here) or in the mouse whole brain

Read the published research article here

Video from work by Iori Tamura and colleagues

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Video originally published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)

Published in Science Advances, July 2024

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[rocinantescoffeestop]

James gives off Jake Peralta vibes in that B99 episode with the Safe House

ARE THEY HYPOXIC ??

[particle196]

Hypoxia-induced NDRG1 C-terminal Poly-phosphorylation Impairs its Tumor Suppressor Function in Renal Cell Carcinoma

Hypoxia is a critical factor driving tumor invasion and metastasis. N-myc Downstream Regulated Gene 1 (NDRG1), a known suppressor of invasion and metastasis in various cancers including clear cell renal cell carcinoma (ccRCC), remains poorly understood in the context of hypoxic regulation.

Global Particle Physics Excellence Awards

website url: physicistparticle.com/

Nomination link: https://physicistparticle.com/award-nomination/?ecategory=Awards&rcategory=Awardee

For Enquiry: support@physicistparticle.com

[mindblowingscience]

​Videos posted to social media showed boats plowing through a blanket of dead fish smothering the water, with the surface barely visible underneath.

​The New South Wales government said on Friday that "millions" of fish had died in the Darling River near the small town of Menindee, in the third mass kill to hit the area since 2018.

​"It's horrific really, there's dead fish as far as you can see," Menindee local Graeme McCrabb told AFP.

​"It's surreal to comprehend," he said, adding this year's fish kill appeared to be worse than previous ones.

​"The environmental impact is unfathomable."

​Populations of fish such as bony herring and carp had boomed in the river following recent floods, according to the state government, but were now dying off in huge numbers as floodwaters receded.

​"These fish deaths are related to low oxygen levels in the water (hypoxia) as flood waters recede," the government said in a statement.

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[loreeebee]

Dementia: Can You Prevent it?

As I get older, every time I forget something I wonder if dementia is imminent. Forgetfulness is common as we age, but just how forgetful is normal, and what level is more worrisome? We all joke about having “senior moments” but when do the jokes become reality? What is Dementia The Center for Disease Control and Prevention (CDC) describes dementia as the following: Dementia is not a specific…

[biology-geology-beaches-india]

The Science Research Manuscripts of S. Sunkavally, p 538.

[theunmanipilateddiaries]

We're basically just allergic to showers at this point. We get so hypoxic that our hands—and our feet, if we're in there long enough—turn blue. (Cyanosis, yippee.) Not to mention, our heart right skyrockets and we start to feel faint, and it's so bad to the point that we have to sit down for either a super long time or until we're done bathing.

Yay, medical issues!

Front: Evan (xe/they), Riley (they/them), Michael (he/corpse/death)

[bpod-bpod]

Seeing Low Oxygen

Visualising tumour cell oxygen deprivation (hypoxia) in a living mouse model with pancreatic cancer using a new fluorescence microscopy approach

Read the published research paper here

Image from work by Timothy Samuel and colleagues

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, June 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[starsontheceilingcomic]

Hypoxic Love

[jaybeeconfusion]

guide to character ages

just so the timeline is a little clearer to people :)

Starkiller - 22

Hypoxia - 20

Calypso (Sofie) - 25, and she was recruited into the team at 18

Hemera (Zoey) - 23, and she was recruited at 17

Nyx (Marquis) - 25, and he was recruited at 19

Atropos (Maia) - 20, and she was recruited at 15

Calypso was recruited first, at 18, then a year later Hemera and Nyx joined. Three months after that, Atropos was added. They trained together for two years, and have been working together in the field for three more at the start of the comic.

[burnt-scone]

I always worry I'm not gonna wake up and the fact it's not unrealistic or exaggerated kinda sucks. I genuinely might not wake up tomorrow.

My will drop as low as 79% in my sleep, and doctors don't even care. I can't move in the morning, and I'm losing more and more memory and speech.

[smedium]

Hypoxia

Have you ever been low on air? Not enough to worry about death or unconsciousness, but enough that you can't help but laugh. Normal breathing isn't enough, so your body must think the convulsions might help. You want to be free, to breath normally, but they won't stop sitting on your chest. After all, you are laughing, so it must be a fun game. You want it to stop, but at least you are getting attention, acknowledged as a person, as someone who exists in this world.

[drforambhuta]

I. Polycythemia Diagnosis:

A. Clinical Assessment:

• The diagnostic process for polycythemia commences with a thorough examination of medical history and physical condition to detect signs indicative of erythrocytosis, assess potential risk factors (e.g., smoking habits, family history of thrombosis), and uncover underlying causes.

• Special attention should be given to symptoms of hyperviscosity syndrome (e.g., headaches, dizziness), skin manifestations (e.g., erythromelalgia), and signs of organ enlargement (e.g., splenomegaly, hepatomegaly).

B. Laboratory Tests:

• Laboratory investigations are crucial for diagnosing polycythemia and understanding its underlying mechanisms. Essential tests include a complete blood count (CBC) with differential, examination of peripheral blood smear, and measurement of serum erythropoietin levels.

• Additional tests, such as JAK2 mutation analysis, bone marrow biopsy, and molecular testing for other mutations associated with myeloproliferative neoplasms (e.g., CALR, MPL), may be necessary to confirm the diagnosis of PV and rule out alternative causes.

C. Imaging Techniques:

• Imaging methods like ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) may be used to evaluate organ enlargement (e.g., splenomegaly, hepatomegaly) and identify potential underlying factors for secondary polycythemia (e.g., renal tumors).

II. Polycythemia Treatment:

Management of polycythemia aims to alleviate symptoms, lower the risk of thrombotic complications, and prevent disease progression. Treatment approaches may vary depending on the underlying cause and severity, often involving a combination of strategies:

A. Phlebotomy (Venesection):

• Phlebotomy is the primary treatment for PV, involving the removal of excess blood to achieve target hematocrit levels (<45% in men, <42% in women).

• Regular phlebotomy sessions usually start at diagnosis and are adjusted based on individual response and disease activity.

B. Cytoreductive Therapy:

• Drugs like hydroxyurea, interferon-alpha, and ruxolitinib may be used in PV patients who do not respond to or cannot tolerate phlebotomy.

• These drugs work by suppressing abnormal hematopoietic proliferation and reducing the risk of blood clotting, with hydroxyurea being the most commonly used and studied cytoreductive drug in PV.

C. Antiplatelet Therapy:

• Aspirin and other antiplatelet drugs are often prescribed to PV patients with a history of blood clots or other high-risk factors to lower the risk of arterial thrombosis.

• Aspirin is usually started at low doses (e.g., 81 mg daily) and may be combined with cytoreductive therapy for better thromboprophylaxis.

D. Treating Underlying Conditions:

• Management of secondary polycythemia focuses on addressing the root cause to relieve hypoxia-induced erythropoiesis and prevent disease progression.

• Interventions may include oxygen therapy for patients with chronic respiratory problems, correction of hemoglobin disorders or other genetic issues, and surgical removal of erythropoietin-secreting tumors.

E. Lifestyle Changes:

• Lifestyle adjustments such as quitting smoking, maintaining a healthy weight, regular physical activity, and proper hydration are vital for improving clinical outcomes and reducing cardiovascular risks in polycythemia patients.

Doctors suggest undergoing regular health checkups for the early diagnosis and treatment of polycythemia. You can choose to undergo a regular full body health checkup at Jaslok Hospital Mumbai, which is one of India's best hospitals for the early detection and management of blood disorders.