#hypoxia

[oddlittlestories]

Whump prompts just reminded me of how much I love House whump, so here’s a quick draft excerpt from the upcoming HH:Reprise chapter (House is in the hospital again):

The team was there, and you know who. Apparently daddy gets sick and mommy comes running.

…Words were—slippery. Out of his grasp. The–it must be getting worse. The–the–

Hypoxia and oxygenation didn’t belong to him anymore, only severed wordless concepts and images of brain matter going dark.

[bpod-bpod]

Click & Detect

Click3D: a method using click chemistry (a class of reactions that make molecules observable) that achieves high-resolution 3D fluorescence imaging of whole organs at unprecedented depth – for example, imaging hypoxia (inadequate tissue oxygen) in a tumour (as shown here) or in the mouse whole brain

Read the published research article here

Video from work by Iori Tamura and colleagues

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Video originally published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)

Published in Science Advances, July 2024

You can also follow BPoD on Instagram, Twitter and Facebook

[mindblowingscience]

​Videos posted to social media showed boats plowing through a blanket of dead fish smothering the water, with the surface barely visible underneath.

​The New South Wales government said on Friday that "millions" of fish had died in the Darling River near the small town of Menindee, in the third mass kill to hit the area since 2018.

​"It's horrific really, there's dead fish as far as you can see," Menindee local Graeme McCrabb told AFP.

​"It's surreal to comprehend," he said, adding this year's fish kill appeared to be worse than previous ones.

​"The environmental impact is unfathomable."

​Populations of fish such as bony herring and carp had boomed in the river following recent floods, according to the state government, but were now dying off in huge numbers as floodwaters receded.

​"These fish deaths are related to low oxygen levels in the water (hypoxia) as flood waters recede," the government said in a statement.

Continue Reading

[auntie-doom]

Folks, my POTS is broken.

This is easily one of the most bizarre things in my life with this lemon of a body. I've been experiencing this predictable heart rate jump when I stand up, without fail, for over three decades... until the heart rate increase started failing mid-leap.

I thought I just wasn't recovering from a cold in March, went to the doc in late April; my lungs were clear, no high WBC, wasn't a secondary infection. But the symptoms were apparently consistent with heart or lung damage. Doc sent me to the ER. The ER chest CT was clear, but while I was hooked to the ER machines I noticed my oxygen saturation kept doing this slow dropping down to alarmingly low levels--and I felt fine--then slow climbing back to 99%. A few minutes later I was hit by intense fatigue & pain.

I checked it on the fingertip pulse/ox after I got home, still happening, but fingertip machine had difficulty with motion and rapidly changing numbers. I got a wearable bluetooth pulse/ox. I'm still seeing the oxygen saturation dips and it's pretty terrifying, yes, WTF is this meat machine doing now? (My doc thinks leakage between oxygenated and deoxygenated blood, which is not reassuring at all. I have a cardiac referral.)

But seeing my POTS get tripped partway through a jump is *freaky*.

Look at that (about 11am). That's not right. My heart rate started to do the typical POTS jump and crashed to below 50 instead, coinciding with a dramatic O2 drop. What the hell. (full screenshot under readmore)

How long has it been doing this? Is my physical hardware just unable to react to the dysautonomia "speed up" signals? Is this why the fatigue has been increasing way past reasonable?

I had a heart ultrasound and multiple EKGs during the POTS diagnosis, but apparently what I need is a heart ultrasound with "bubble test," which I have never had. I even wore a pulse/ox for a sleep study but this doesn't happen at night! Mostly. It does coincide with activity... frequently... sometimes I am not doing anything... but almost always I am awake.

My POTS is broken and I am so weirded out.

[promptsforyourwhumpfic]

Whump Prompt #1106

@thebewingedjewelcat asked:  Do you have any being choked prompts?  One of my OCs has a phobia about his neck being touched.

Choking doesn't just have to be hands on the throat. Your whumper could notice how the whumpee actively tries to pull away when their hands get too close to their neck.

“Oh darling, don’t worry, I wont lay a hand on that pretty neck of yours.”

Instead, they use other methods:

Pulling the whumpees shirt around their neck. 

If they’re wearing a tie: it could be tightened to the point of near strangulation.  

Chains/belts/rope could be looped around their neck. Just looped and hanging loose. Just enough to drive your whumpee crazy.

The sudden tightening of the previous items jolting your whumpee awake. 

To keep the whumpee subdued when transporting them, they loop a collar and leash around his neck. They make sure to pull extra tight when your character steps out of line :)

When all the chafing/pulling causes injuries, the whumpee makes sure to keep the bandages nice and tight to cause more pain and suffering. 

After all is said and done, your whumpee panics anytime something nears their neck - even the collar of a t-shirt!

And a little added bonus... what about the potential for hypoxia and brain injury?

After all... the whumper promised they wouldn’t lay a hand on their neck.

[arecaceae175]

if youre still doing them, unconscious for the three sentence fics! (as a continuation to running out of time) ❤️

(Continuation of running out of time)

“Hurry!” Wild yelled, even though it left his gasping for air. He put one hand on his throat and left the other wrapped around Sky’s limp shoulders.

The other heroes were close. Wild could finally hear them. They had to be careful not to collapse the cave further, but Wild’s heart beat faster with every passing second.

“Is Sky with you?” Someone yelled. Wild barely heard it through the rocks. He sucked in as deep a breath as he could, but was overcome by a fit of coughing. Wild was left gasping, black spots dancing in his vision, and he felt himself leaning more heavily against Sky.

Was there a question? Why was he trying to talk?

“Champion!”

The yell pulled Wild out of the haze. He blinked his eyes rapidly and tried to control his breathing.

“Is Sky with you?”

Wild blearily looked at Sky. He was curled up at Wild’s side, and if Wild didn’t look too closely at his blue lips Sky almost looked peacefully asleep.

“Wild, are you there? Is Sky with you?”

The voice sounded stressed. Maybe Wild could help. Wild shook his head to clear his foggy mind and allowed himself three full breaths before he answered. “Unconscious,” he yelled as loud as he could.

There was a response, Wild thought, but he was too tired to make it out. Wild let his eyes slip shut and head rest on Sky’s. The other heroes would be here soon; surely a nap wouldn’t hurt.

(Next part ->)

[starsontheceilingcomic]

Hypoxic Love

[jaybeeconfusion]

guide to character ages

just so the timeline is a little clearer to people :)

Starkiller - 22

Hypoxia - 20

Calypso (Sofie) - 25, and she was recruited into the team at 18

Hemera (Zoey) - 23, and she was recruited at 17

Nyx (Marquis) - 25, and he was recruited at 19

Atropos (Maia) - 20, and she was recruited at 15

Calypso was recruited first, at 18, then a year later Hemera and Nyx joined. Three months after that, Atropos was added. They trained together for two years, and have been working together in the field for three more at the start of the comic.

[burnt-scone]

I always worry I'm not gonna wake up and the fact it's not unrealistic or exaggerated kinda sucks. I genuinely might not wake up tomorrow.

My will drop as low as 79% in my sleep, and doctors don't even care. I can't move in the morning, and I'm losing more and more memory and speech.

[bpod-bpod]

Seeing Low Oxygen

Visualising tumour cell oxygen deprivation (hypoxia) in a living mouse model with pancreatic cancer using a new fluorescence microscopy approach

Read the published research paper here

Image from work by Timothy Samuel and colleagues

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, June 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[smedium]

Hypoxia

Have you ever been low on air? Not enough to worry about death or unconsciousness, but enough that you can't help but laugh. Normal breathing isn't enough, so your body must think the convulsions might help. You want to be free, to breath normally, but they won't stop sitting on your chest. After all, you are laughing, so it must be a fun game. You want it to stop, but at least you are getting attention, acknowledged as a person, as someone who exists in this world.

[drforambhuta]

I. Polycythemia Diagnosis:

A. Clinical Assessment:

• The diagnostic process for polycythemia commences with a thorough examination of medical history and physical condition to detect signs indicative of erythrocytosis, assess potential risk factors (e.g., smoking habits, family history of thrombosis), and uncover underlying causes.

• Special attention should be given to symptoms of hyperviscosity syndrome (e.g., headaches, dizziness), skin manifestations (e.g., erythromelalgia), and signs of organ enlargement (e.g., splenomegaly, hepatomegaly).

B. Laboratory Tests:

• Laboratory investigations are crucial for diagnosing polycythemia and understanding its underlying mechanisms. Essential tests include a complete blood count (CBC) with differential, examination of peripheral blood smear, and measurement of serum erythropoietin levels.

• Additional tests, such as JAK2 mutation analysis, bone marrow biopsy, and molecular testing for other mutations associated with myeloproliferative neoplasms (e.g., CALR, MPL), may be necessary to confirm the diagnosis of PV and rule out alternative causes.

C. Imaging Techniques:

• Imaging methods like ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) may be used to evaluate organ enlargement (e.g., splenomegaly, hepatomegaly) and identify potential underlying factors for secondary polycythemia (e.g., renal tumors).

II. Polycythemia Treatment:

Management of polycythemia aims to alleviate symptoms, lower the risk of thrombotic complications, and prevent disease progression. Treatment approaches may vary depending on the underlying cause and severity, often involving a combination of strategies:

A. Phlebotomy (Venesection):

• Phlebotomy is the primary treatment for PV, involving the removal of excess blood to achieve target hematocrit levels (<45% in men, <42% in women).

• Regular phlebotomy sessions usually start at diagnosis and are adjusted based on individual response and disease activity.

B. Cytoreductive Therapy:

• Drugs like hydroxyurea, interferon-alpha, and ruxolitinib may be used in PV patients who do not respond to or cannot tolerate phlebotomy.

• These drugs work by suppressing abnormal hematopoietic proliferation and reducing the risk of blood clotting, with hydroxyurea being the most commonly used and studied cytoreductive drug in PV.

C. Antiplatelet Therapy:

• Aspirin and other antiplatelet drugs are often prescribed to PV patients with a history of blood clots or other high-risk factors to lower the risk of arterial thrombosis.

• Aspirin is usually started at low doses (e.g., 81 mg daily) and may be combined with cytoreductive therapy for better thromboprophylaxis.

D. Treating Underlying Conditions:

• Management of secondary polycythemia focuses on addressing the root cause to relieve hypoxia-induced erythropoiesis and prevent disease progression.

• Interventions may include oxygen therapy for patients with chronic respiratory problems, correction of hemoglobin disorders or other genetic issues, and surgical removal of erythropoietin-secreting tumors.

E. Lifestyle Changes:

• Lifestyle adjustments such as quitting smoking, maintaining a healthy weight, regular physical activity, and proper hydration are vital for improving clinical outcomes and reducing cardiovascular risks in polycythemia patients.

Doctors suggest undergoing regular health checkups for the early diagnosis and treatment of polycythemia. You can choose to undergo a regular full body health checkup at Jaslok Hospital Mumbai, which is one of India's best hospitals for the early detection and management of blood disorders.

[cebozcom]

Climate Change Impact: Oxygen Depletion Threatens Marine Life | CeBoz.com

Rising temperatures from climate change depleting oxygen in coastal waters, threatening marine life

[randomwikiarticles]

Helios Airways Flight 522 was a scheduled passenger flight from Larnaca, Cyprus, to Prague, Czech Republic, with a stopover in Athens, Greece. Shortly after take-off on 14 August 2005, air traffic control (ATC) lost contact with the aircraft operating the flight, named Olympia; it eventually crashed near Grammatiko, Greece, killing all 121 passengers and crew on board. It is the deadliest aviation accident in Greek history.[1][2]

An investigation into the crash by the Air Accident Investigation and Aviation Safety Board (AAIASB) concluded that the crew had neglected to set the pressurization system to automatic during the take-off checks. This caused the plane not to be pressurized during the flight and resulted in nearly everyone on board suffering from generalized hypoxia, thus resulting in a ghost flight.