#diabetes meds

[mcatmemoranda]

I never use sulfonylureas. I just know they can cause hypoglycemia. So I would stop it if I were going to start a pt on a GLP-1 receptor agonist. From UTD:

Mechanism of action – Sulfonylureas bind to the sulfonylurea receptor on the adenosine triphosphate (ATP)-sensitive potassium channel (K-ATP channel) of the pancreatic beta cells, leading to inhibition of the channels with subsequent alteration of the resting potential of the cell, calcium influx, and stimulation of insulin secretion.

•Clinical use – Sulfonylureas usually lower glycated hemoglobin (A1C) by 1 to 2 percent.

-Initial therapy – A short-acting sulfonylurea (or one with relatively lower risk for hypoglycemia) is a reasonable option for initial therapy (along with lifestyle intervention) in patients without established cardiovascular disease (CVD) who have contraindications to or intolerance of metformin, particularly if cost is a concern.

-Combination therapy – Sulfonylureas are most often used in combination with other oral hypoglycemic drugs in patients with persistent hyperglycemia after lifestyle intervention and metformin. They are generally not used in combination with insulin.

-Choice of sulfonylurea – When a decision has been made to treat with a sulfonylurea, we suggest a shorter-duration sulfonylurea or one with relatively lower risk for hypoglycemia, such as glipizide, gliclazide (not available in the United States), or glimepiride (Grade 2C). Glyburide (glibenclamide) and other long-acting sulfonylureas have a higher incidence of hypoglycemia.

•Side effects – The most common side effects of sulfonylureas are weight gain and hypoglycemia.

●Meglitinides

•Mechanism of action – Meglitinides are structurally different from sulfonylureas and exert their effects via different pancreatic beta cell receptors, but they act similarly by regulating K-ATP channels in pancreatic beta cells, thereby increasing insulin secretion. The clinical efficacy of meglitinide monotherapy is similar to that of the sulfonylureas.

•Clinical use – Meglitinides are most commonly used as add-on therapy for patients who do not reach glycemic goals with metformin, particularly if there are contraindications to sulfonylureas or patient preference limits the use of insulin or other agents. Meglitinides are pharmacologically distinct from sulfonylureas and may be used as initial therapy in patients who have an allergy to sulfonylurea medications. For patients who have highly variable diets (eg, inconsistent timing, size, and/or carbohydrate content of meals) or substantial postprandial hyperglycemia with large meals, but do not need additional medication the rest of the time, repaglinide may be taken at those large or carbohydrate-rich meals only.

•Choice of meglitinide – When a decision has been made to treat with a meglitinide, we suggest repaglinide (Grade 2B). Repaglinide has slightly superior glycemic efficacy compared with nateglinide. Repaglinide is principally metabolized by the liver, with less than 10 percent renally excreted. Thus, it can be used safely in patients with chronic kidney disease. Nateglinide is hepatically metabolized, with renal excretion of active metabolites. It should be used with caution, if at all, in patients with chronic liver or advanced kidney disease.

•Side effects – Meglitinides have a similar risk for weight gain as sulfonylureas but possibly less risk of hypoglycemia.

[gazagfmboost]

Jbreel Farroukh- elderly diabetic woman

Vetting: Social media content going back to 2018, many highlights with others, mom & at work. Instagram: Jbreel.f98 & fardousfarroukh & emjbreelfarroukh & company IG toptech Fund Currency: € Euro

You can see how much love Jbreel has for his dear mother in all of his content with her, multiple members of the family reached out hoping for help with sharing their story. He is an ambitious young man who lost his company but has hope to save his diabetic mother & to help his sister escape to finish her pharmacy degree. UPDATE - GFM Froze their gofundme, & they're starting over from scratch! I hope that you will please consider helping them inch back towards their goal with any tiny donation to the updated fund or by giving a heart or sharing their story-

I appreciate you helping their family to feel seen & heard during these terrible times!

Help Jbreel and his family to evacuate from Gaza gofund.me/a8ffe422

[er-cryptid]

Symptomatic Hyperglycemia

Patreon

[briarpatch-kids]

I hate how society is so fat phobic that people will question why someone with t2 diabetes needs a medication to control blood sugar more than their need to lose weight. Like maybe, just maybe, having an uncontrolled blood sugar of 300 is just a little more dangerous than you potentially having health problems years down the line. One is decidedly more dangerous.

[heardatmedschool]

“What a stress test is for the heart, pregnancy is for the pancreas.”

About gestational diabetes.

[tonitheloftwing]

I love being a pre-med major because I genuinely love learning about the human body & its functions but the assignments can so often be really fucking ableist 😭 (and fatphobic, but that’s another topic)

Like, for my nutrition class, we had to write some quick responses about what lifestyle changes we could make to lower our risk of type 2 diabetes. My response was basically “I know I’m at a high risk for type 2 diabetes-” (or at least I think I am. That might be internalized fatphobia) “-but I can’t really make any lifestyle changes that would be healthy. I’m recovering from an eating disorder so any kind of dieting would be extremely bad for my mental health. And I have severe chronic pain to the point where being on my feet for too long will leave me bedridden for the rest of the day, so I can’t really exercise without being in like 7/10 pain”

Obviously that sucks because I shouldn’t have to give my professor my medical history to justify why I still let myself eat Oreos. But then I was like. WTF would she want someone with diabetes to do for this assignment??? Someone with type 1 would just have to say something like “I don’t have to worry about getting type 2 diabetes because my pancreas already shat itself”, but I cannot imagine how someone with type 2 would feel. Again, I’m not diabetic, but that’s got to feel so horrible?????? Your schoolwork shouldn’t be telling you that it’s your fault that you’re diabetic 😭

Idk that’s just my premed student ramblings for the day. My nutrition prof is mostly okay (she’s only very lightly fatphobic, and did allow me to make accommodations for my eating disorder- otherwise I would have had to keep a diet journal 💀) but if she was more sucky I would not be doing well rn

[anderswasrightt]

my a1c went from 6.2 to 6.1, babeyyyy! my next goal is 6.0. 💪😎

for reference, the diagnostic for when the CDC considers you "actually diabetic" is 6.5, and my clinic uses 6.4. so, my a1c is that of a non-diabetic person. i am fuckin KILLIN it, yall.

now, there's a lot to say about whether or not my a1c is actually HEALTHY or not. is it good for a type 1 diabetic? hell yeah. is it still gonna cause long-term damage? yeah, unfortunately. but i'll take what i can get. it's better than 10, which is what it used to be.

[bigbutchhimbo]

please help a disabled butch get his meds!

howdy everyone, i wouldn't do this if i wasn't desperate, but due to a mistake that was out of my hands, i've lost my medicaid and have yet to get it back. i'm diabetic and have severe anxiety and depression, and i need help raising money for my meds as i can't afford them without insurance.

anything helps, i'm hoping to raise about $100 to at least get an emergency supply of most of my meds. if you can't help that way, please share and relobg this. thank you!

c: $bigbearboy

v: himbobutch

ppal: tuckerthebear

[lesbiangiratina]

Damn. The disorder really can be obsessive and compulsive.

[nhaneh]

shortages of vital medicines kind of highlights how the concept of intellectual property is pretty fucked up actually and also bill gates is an actual monster for reasons wholly unrelated to all the conspiracy bullshit

[videcoeur]

I want to thank everyone for their patience on just about everything, whether it be art or rp replies. I've started a new treatment about 3 weeks ago and the side effects are insane. I am doing my best, but until I get adjusted, which might take a bit since its a progressive dosage kind of med, I will be on reduced activity notice.

Not that im super active to begin with but consider this a warning <3 Thank you for understanding! I promise I'm not ignoring everyone, I'm just nerfed as heck right now.

[aithne]

Deeply irritated that I have now spent four months following a medically supervised diet that is designed to make specific blood test markers better only to have all of them get worse.

(Also deeply irritated that I have to wait until March to start the medication that should actually make a difference, because of insurance company fuckery.)

[bonefall]

HI ok u dont gotta post this i just wanted to give some info bc u mentioned wanting to do disability right and i just wanted to give info u might find useful. Leopardstar has diabetes and while idk if she gets murked or not before that goes into full force, but shed absolutely not be herself during that whole shebang.

The first signs would be increaded dirt place visits to go pee, and needing to drink a lot. Wouldn't be too hard for cats to miss this since they live in riverclan, Clan Of Water, but it'd be an UNUSUAL amount. Personally, i noticed it myself and genuinely got concerned bc i was drinking triple what i normally did and would wake up in the middle of the night specifically to chug water.

Next thing would be her getting skinnier and out of breath more easily. Her body would effectively be eating her muscles away and shed 100% be unable to fight well or even at all at this point- accounting for exercise and a relatively low carb diet of fish, maybe these symptons would show up after a month and a half? At this point a medicine cat could notice the odd lack of energy but i doubt it'd be obvious what was happening, the medicine cat might pat her on the back, give her some herbs (honey or berries would be BADDD), and send her off.

Soon after shed start throwing up sugar, which just straight up burns ur throat like hell. Its hell. She'd also not feel too hungry now- in reality shes starving, and her body is too busy not dying to notice nor care. At this point if Mistyfoot did Her Thing, Leopardstar would barely be able to stand let alone fight her. In her final days shed be completely weakened and barely able to focus, and she'd start getting pains in her stomach and pelvis. I was unfortunate enough to cut it extremely close, and when i was diagnosed i was told i had less than half a week to live if i hadnt went to the hospital. Depending on if the medicine cat catches on, they could absolutely be making everything 50 times worse by feeding her berries or honey to soothe her burning throat, feeding a cycle of eating honey and throwing up the sugars in the honey. I did this with gingerale and it SUCKED.

Now!! If you want to have leopardstar put up a FIGHT and have her have diabetes and live with it, theres a few ideas. Firstly, only type 1 i believe can be treated without insulin. Secondly, Bloodclan could 100% steal human insulin and give it to Riverclan. The two are compatible i /think/. Three, idk the exact process but apparently you can make ur own insulin using the pancreas from animals, which she could use to survive. Four, without medicine, shed have to do a lot of exercise and manage her diet. With a raw fish diet it's much easier, but she'll probably not be too happy about not being able to eat tunnelbuns without feeling like crap and throwing it up after.

Going down the Bloodclan sourced medicine route, Misty could also kill her using the medicine. Insulin is a delicate balance- too little and you start throwing up and ur body eats u again. Too much and you have no energy to move and you can die within the next hour. Doesnt even take that much, a dose of 18 when youre supposed to take 16 can be deadly. Double that amount and i doubt even a medicine cat could save her even if she knew- low bloodsugars make someone irrational or emotional + extremely whoozy, and its HARD to force feed someone honey when theyre adamant that theyre perfectly fine and just a little sleepy, thats all. In her sleep, and Leopardstar would maybe wake up briefly, feel extremely tired and odd and unable to move, and fall asleep and die.

Anyways this has been ur probably too long rant about diabetes and leopardstar hopefully its helpful in some way o7

[ID: A student is taking notes]

You know, in my rewrite, Leopardstar is actually going to be killing Crookedstar. Not in a way where she would be caught-- I had been thinking it would be a generic poisoning. Maybe it would be dramatic and fascinating if Leopardstar had actually pulled this insulin trick... only to then recognize that Mistyfoot is trying to poison her in the same way.

I'm committed to Leopardstar dying in a battle with Mistyfoot. I had this awesome idea for the Sweet Nothings AU where a Villain Thornclaw lead Hollyleaf somewhere that the winner wouldn't be caught for their victory, so they could have a proper fight to the death.

What if I used that plotbunny here instead? Leopardstar realizing that Mistyfoot had brought her the wrong dose of insulin (I will work out how they get insulin when I make a herb guide for it), and deciding if either of them is going to die, they will die honorably. Not by trickery, but by the strength of their claws.

So she calls for Mistyfoot, tells the Clan they will be confronting rogues at the border, and then they march towards their final confrontation.

[irhabiya]

today sucked the life out of me ya Allah

[heardatmedschool]

“If you wouldn’t hesitate about giving antibiotics to a pneumonia, don’t either when giving insulin to hyperglycemia.”

[wikipediapictures]

Insulin (medication)