#type 2 diabetes insulin

[ayurvedicwellness]

If you have "Type 1 Diabetes" and want to live a long life then hurry up and click the link below

www.diabaplus.com

www.deemark.com

[diabetes-health-corner]

Insulin Types and Their Use

The body needs to be able to manage the glucose levels in the blood through the day and night, as well as during meals when there is a sudden overload of glucose. Different types of insulin take care of these needs.

Read more to know the types of Insulin: https://www.freedomfromdiabetes.org/blog/post/insulin-types-and-their-use/2822

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[championlaura222]

I'm sick of the moraliazation of illness/disability. I see it a lot when it comes to type 2 diabetes. I'm sick of the idea that it's just "fat person disease." Talk to pretty much any doctor and they'll tell you that the main factor in type 2 diabetes is genetics. My mom's side has a higher likelihood for type 2 diabetes, my dad's side does not. Despite my dad being extremely overweight for much of his life, not even a sign! My Nan had some weight gain in her 50s, not that much from how much she weighed, and she ended up with it. There's no "right" way to be ill, I'm tired of the stigma around the idea that a person "does it to themselves" and thus is okay to ridicule and not listen to. In fact, Weight in general has more to do with genetics than most other factors! Think about how many people live off redbull and fast food and don't gain weight from it! And even if someone did get sick because of their actions, you shouldn't go around ridiculing them over that!

[buttfrovski]

I HAVE TO DO RESEARCH ON THE PRIME ENERGY DRINK AND I KEEP ACCIDENTALLY CALLING IT CRED 😭😭😭😭😭😭

[webbydoo]

diabetes awareness art

[simply-ivanka]

May 26, 2020

Today, under President Trump’s leadership, the Centers for Medicare & Medicaid Services (CMS) announced that over 1,750 standalone Medicare Part D prescription drug plans and Medicare Advantage plans with prescription drug coverage have applied to offer lower insulin costs through the Part D Senior Savings Model for the 2021 plan year. Across the nation, participating enhanced Part D prescription drug plans will provide Medicare beneficiaries access to a broad set of insulins at a maximum $35 copay for a month’s supply, from the beginning of the year through the Part D coverage gap. The model follows on the Trump Administration’s previously announced 13.5 percent decline in the average monthly basic Part D premium since 2017 to the lowest level in seven years.

[the-kestrels-feather]

I hope all of the people using Ozempic and Mounjaro to lose weight without a perscription and the celebrities having fucking "Ozempic and Mounjaro Parties" are enjoying it because I (a person who actually needs it for diabetes management and has a perscription) am about to miss my 3rd week of shots because I've called 3 pharmiacies and not a single one has it.

[wikipediapictures]

Insulin (medication)

[beyondthebloodsugar]

Understanding the Difference: Type 1 vs Type 2 Diabetes

When it comes to diabetes, many people often feel confused about the differences between Type 1 and Type 2. It's like trying to tell apart two siblings who look similar but behave differently. Let's break it down in a simple way.

What Is Type 1 Diabetes?

Type 1 diabetes is like a surprise party that nobody wants. This type happens when the immune system mistakenly attacks the insulin-producing cells in the pancreas. So, what’s insulin? Think of it as a key that opens the door for sugar (glucose) to enter your cells for energy. Without insulin, sugar just lingers in your blood, leading to high blood sugar levels.

Type 1 diabetes usually hits younger people, often in childhood or early adulthood. It’s not about lifestyle or diet; it’s an autoimmune condition that needs insulin therapy for management. People with Type 1 must regularly monitor their blood sugar and take insulin shots or use an insulin pump.

What Is Type 2 Diabetes?

Type 2 diabetes is like the friendly neighbor who becomes less friendly over time. This type occurs when the body either doesn’t use insulin well or doesn’t produce enough of it. It’s often linked to lifestyle factors like being overweight, not exercising, and poor eating habits.

Unlike Type 1, Type 2 can develop at any age but is more common in adults. Sometimes, people can manage it with lifestyle changes or medication. However, some may require insulin if the condition worsens. Managing Type 2 often requires a more proactive approach, like changing diets and incorporating exercise.

Key Differences Between Type 1 and Type 2 Diabetes

Cause and Onset

The root cause is one of the biggest differences. Type 1 is an autoimmune condition, while Type 2 is mainly influenced by lifestyle. Type 1 develops quickly, often in childhood or young adulthood, and Type 2 usually creeps in slowly, often appearing later in life.

Symptoms

Although symptoms overlap, they can show up differently. Type 1 symptoms might appear suddenly and include excessive thirst, frequent urination, and extreme fatigue. On the flip side, Type 2 symptoms might develop gradually and can include blurred vision, slow healing wounds, and tingling sensations.

Treatment Methods

Type 1 diabetics must use insulin as part of their daily routine. There’s no cure, but insulin helps manage blood sugar levels. For Type 2, treatment can start with lifestyle changes and may progress to oral medications or insulin if needed.

Who's at Risk?

Type 1 diabetes doesn’t have clear risk factors, but having a family history can increase chances. Meanwhile, Type 2 diabetes is often linked to risk factors like age, obesity, family history, and physical inactivity. It’s like the difference between being born into a family of athletes versus being raised in a couch-potato household.

Final Thoughts

In a nutshell, Type 1 and Type 2 diabetes involve the body's relationship with insulin but are unique in their causes, onset, and treatment. Understanding these differences is crucial for managing each condition effectively. Whether it’s Type 1 or Type 2, staying informed is the key to controlling diabetes and leading a healthy life. It’s all about knowing your body and what it needs!

[eatclean-bewhole]

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[conequette]

Hi! I'm still having high blood pressure and fever. Being diabetic is awful .Help me get what I need so when I leave I can stay healed and get better today. #Type1Diabetes 😭. I'm a disabled mom so can't work after I had an accident. I've a spinal cord problem ..my blood sugar is high and I'm last to my pen, i need insulin to save my life and medical care for the past 2 months.

This is a life-threatening situation.share widely & donate 🙏

hi! i am very sorry, but i am not able to donate. i will do my best do share and spread the word about your situation. no one should have to go through this, i'm hoping you'll get the help you need as soon as possible.

[architectureenthusiast]

It's that time of the month when my insulin doesn't work when the sun is up 🥳.

[aetherglow]

Following through with plans I made when I was more able bodied this summer by going to the yearly concert I usually go to felt nice because I was able to do it

But also I was only barely able to do it. Trying to work around my energy levels is a genuine and legitimate challenge every day now and I don't know for sure if it'll get better. Like I presume it will since it's a side effect of my new medication but man things have been super hard the last couple months

[punishedsaints]