#injury repair

[bpod-bpod]

Piezo Ignites Macrophages

Analysing the relationship between macrophages – large, multifunctional cells of the immune system – and fibrosis of the liver resulting from repeated injury and repair in mice reveals the role of a molecule called Piezo1 via which macrophages sense mechanical signals of tissue 'stiffness', alerting them to clear dead cells limiting inflammation and fibrosis

Read the published research article here

Image from work by Yang Wang, Jin Wang and Jiahao Zhang and colleagues

Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Image originally published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)

Published in Science Advances, June 2024

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[hellenhighwater]

Here's to all the burnouts.

I'm not sure what to name this one but it is working well! Another oil lamp. It's a figure about twice the size of the mythology series figures.

[tinytracys]

When a tent-related disaster occurs, Scott is always ready to leap in and lend a hand with the best knot for the job.

Alan… needs a little more practice.

[thebramblewood]

An Ill-Fated Afterparty: Part III

Previous / Next

Lilith: [frantically] CALEB!!!

Caleb: [mutters] This isn't your problem, Caleb. Do not get involved. Do not get involved. Do not-

Lilith: [hysterically] CALEB!!!

Caleb: Damn it.

-

Caleb: Jesus Christ, Lilith.

Lilith: I didn't mean to do it, I swear!

Caleb: You always go too far.

Lilith: It was an accident!

Caleb: Well, maybe if you exercised even a sliver of self-control-

Lilith: You can lecture me later, Caleb. Fix her!

Caleb: Look at her, Lil. She's beyond repair.

Lilith: Then turn her!

Caleb: It’s far too late for-

Lilith: Please try. It was a moment of weakness. Is that what you want to hear? I'm weak and you're strong and I need your help! I'll get on my knees and beg if I must!

Caleb: [sighs heavily] Just get out of my way.

-

Caleb: I’m sorry, Lilith. I think she’s too far gone.

Lilith: Then get rid of her.

[genius-built-donatello]

[Don walks to the corridors with no shortage of expectations for how this is going to go.

He knows he'll have to go around repairing the vents. And the passage. And the cell, and the vault, and the doors she broke, and anything else she destroyed in her path including any circuitry she may have came into contact with and corrupted and any people she may have interacted with who may've been exposed to this unstable infection and-

Their fingers twitch on their bō, and they file that train of thought away for the time being. God, they don't have time for this. On top of everything else, on top of their injuries, on top of Darner just flying off, he does not have time to fucking scour the entire base, and he does not have time for yet another backup plan if this doesn't work out.

They stop near the vent Shelldon's fight had taken place by, pulling up the camera feeds. They'd issued an order for everyone to leave the vague surrounding area, but, still, she could do a lot of harm if they didn't manage to stay here.

It's another second before a mechanical arm extends from his shell, sending a camera through the vent while he waits, bō extended.]

@echo-nova-2036

[north-winds1]

Been thinking about redesigning some of my designs

+ me figuring out design stuff

[kaettytropmignon]

since the underwear was the first/only piece of clothing he ever received then i think it's reasonable to view them as like the equivalent of a hospital gown. out there dodging death with three baby brothers in tow and no pants and we respect it

[selfspinninglies]

If a robots concious were to be [consentually or non consentually] transferred to an organic body do you think they would be horrified at a vessel that is uncontrollably ever growing and changing even in the smallest ways. Because i do

[skunkes]

Whats the major injury Talon went through? Would you consider one day making like a timeline sorta thing of Talons long life to the present day?

Talon is a baby in oc years, he's only like, 3, so his Lore has changed so much already, and therefore I don't wanna prematurely make a timeline knowing it may change like. Next week.

Especially since some stuff is being mixed around in my brain This Week Alone!!!

Anyway, Talon got the common vampire punishment of being Buried Alive but with the addition of sustaining a brain injury right before. This was done by the same group who Found Out and Scientific Method Proved that his body is very slow to heal wounds, if at all, so it was another dollop of cruelty hoping he'd just never recover and be in barely conscious maimed stasis until, well, idk, maybe we'll dig him up eventually if we remember where we left him. Might be interesting to see if the effects of the vampire failsafe puts an extra strain on the resources of a damaged body with a damaged undead brain, etc

his body did its best to patch that up considering such an event would be pretty difficult to recover from for even an ordinary vampire, but of course there are lingering symptoms, on top of those of all the other injuries he's ever sustained, sustained, sustained

[obsidian-art04]

Demon Slayer Jjk crossover, anyone?

Edit: Redraw here!

[bobateaboo]

hey guys, remember this post by @kandidandi ? well funny story i kinda-

You didn’t expect the fire. No one did, really

It’s just that one minute, you’re helping Sun clean the daycare, and then the next, you’re running through the hallways, with him yelling at you to go faster, faster, as the scorching heat bubbles the wallpaper, smoke burning your eyes and throat.

You don’t register the cracking along the walls and ceiling until Sun cries out behind you and you turn to see him with a beam pinning his leg, his red and yellow striped pants darkening to charcoal as they’re caught in the blaze.

“Sun!” You start running back, the cracking of wood and plaster filling your ears but you have to get him-

“Starlight, no!” he’s reaching to press the buttons on his chest- why isn’t he trying to get out? -and something slots open and falls into his hand, throwing it at you just a moment before his eyes darken

It damn well nearly takes your eye out, hitting you right on the line of your eyebrow, making you fumble to catch it. You open your mouth to ask what the hell this is, tell him to get up, he has to get up- and then the crackling of wood fills your senses as the rafters cave in before you in a cloud of embers, crushing your best friend like a bug.

You throw your arms over your face to keep the worst of the blast out of your eyes, hand fisted over whatever the thing he gave you was, looking forward in disbelief as you cry out.

“Sun! Sun, say something, I’m coming to get you out!”

You run to the pile, ignoring the blisters that swell up on your hands as you tear away burning plaster, trying to get to him some way, any way-

It’s one of the staff bots who ended up saving your skin. You were never really sure how sentient they were, with their simple tasks and pre-recorded voice lines, but you owe that bot your life if you can find them again. If… if they… will their cpu chip be salvaged? Or are they as gone as any human would be in their shoes?

They hauled you to the entrance, holding you under the arms, anything but throwing you away from the door. But it’s not like they could follow. Staff bots aren’t permitted to leave the pizzaplex. So when the rest of the roof caved in, your friend was crushed into gears and wires just like everyone else.

You stared at the burning building, looking down at the small object in your hands. It’s a cpu chip, half bright yellow and half sleepy blue, sitting in the palm of your hand. You can fix this.

You can fix this.

You lay back on the pavement, listening to sirens fill the air as smoke billows up into the early morning sky.

“Good news, I found this old thing, so I don’t have to make your guys’ new body from scratch anymore. I just have to do some fixing up, and- ow, ow, ow!”

You jumped back, waving your hand. Every inch of your skin was covered in bandages, but the burns still hurt when you touched something too cold too fast. Or at all. Or touched something. Or didn’t touch something.

God bless human skin cells.

You sighed, (carefully) grabbing your wrench. Your workshop was… minimalist, to say the least. And by that you mean you’d never so much as fixed a bike before the incident, and have been functioning in your musty garage with youtube tutorials and an old toolbox you found in the basement.

That’s why you got into dumpster diving. You didn’t have the skill or the budget to build your boys from scratch, you needed something you could start with.

What you end up with is one of the prototype models for Sun and Moon. It’s not exactly what you’re used to, it was just made to test that all the features work, none of the decorations you were used to. Just white matte limbs and a round face, no rays, no hat, just white eyes and a big smile set across his face.

You can’t get over how bald he looks. You ended up finding an old beanie and a pair of oversized sweatpants, spending some time maneuvering around your burns as you got them on. Sure, it took longer than intended, but it just felt indecent to be treating them naked.

“The good news is, though, that it has your guys’ light sensors and voice box already set up, so I won’t have to try to make those! Which, thank god, I have no idea how this wiring stuff works-”

You know they can’t hear you, but it feels good to talk to them. It’s too quiet in here, y’know? You’ve got the chest chassis popped open, reconnecting wires that have broken over the years, oiling the endoskeleton, working gunk out of the joints. It wasn’t in the best shape, but it was a hell of a lot better than their last body…

…

A-and besides, this one was only temporary! Management told you the old cpu chip was probably fried, that they would just make a new Sun and Moon AI (without all the “quirks”, they’d said) once they’d rebuilt the place. But !! Once you get it working, they’ll have no reason not to keep your friends alive!

You take a deep breath, wiping sweat from your forehead (and wincing, when that agitates the burns). This should be it… you think you fixed all the wires, you just have to load them in and hope for the best.

You kiss the chip lightly before slotting it into place, holding the buttons on their chest and counting to five. “Please work… I miss you guys…”

The whirring of machinery starts up as you hold your breath. Does praying work if you’re not religious? Cause you’re begging to someone, you don’t know who.

Your eyes are screwed shut so tight that you don’t notice they’re moving again until cool arms envelop you, oh so gently.

“We missed… you too….”

[randomly--accessed--memories]

I don’t know much about transhumanism, but there’s a certain irony in Vox, who saw no issue with upgrading his body, who jumped at the opportunity to fix every minor flaw with his body, being brought down by the one thing he can’t replace: his mind.

[ghoul--doodle]

Why is one of Naro’s eyes all blue?

It’s broken! He has a lot of complicated feelings about it, so he prefers to just leave it be

[bpod-bpod]

Mending Muscles

Your blood contains cell fragments – platelets – that can supercharge muscle repair. It's why platelet-rich plasma injections are used to treat muscle injuries. Researchers investigate why this works using fluorescence microscopy of uninjured and injured mouse muscles (pictured). Platelets accumulated after injury and antibody treatment to deplete injured muscles of platelets prevented immune cells called neutrophils from accumulating in these muscles. This also impaired repair. As platelets release chemical messengers called cytokines, researchers measured cytokine levels after injury in normal and platelet-depleted muscles. Platelet depletion reduced levels of the neutrophil-attracting cytokines CXCL5 and CXCL7. Comparing muscles from normal mice (before injury, left; 2 weeks later, middle) and those lacking CXCL7 (2 weeks after injury, right), revealed mice lacking CXCL7 recruited fewer neutrophils upon injury and 2 weeks later had smaller muscle fibres (zoom, bottom right). Platelet-derived CXCL7 therefore promotes muscle repair via neutrophils – this pathway could be exploited to boost repair.

Written by Lux Fatimathas

Image adapted from work by Flavia A. Graca and colleagues

Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, March 2023

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[objectsarebestest]

The doll I fixed up!

[ID: On the left is a naked LOL OMG doll with mud splotches, faded body parts, and dirty hair. On the right is the same doll wearing a light blue shirt and dark blue pants, with an even skin tone and a red buzzcut hairstyle. End ID]

Before: August 2023

After: March 2024

Feel free to ask me any questions.

[orthopedicsurgeondelhi]

Dr Vishwadeep Sharma is Director of Arthroscopy & Sports Injuries, Shoulder & Knee Surgeon Fortis Hospital Vasant Kunj and he is associated with hospital since 2013. He specializes in Shoulder, Knee & Sports Injuries. With more than 15 years of dedicated experience in Arthroscopy of the Shoulder & Knee. Dr Sharma has keen interest in Sports injuries with many years of experience in treating young athletes and players involved in various professional Sports. He is one of the best Orthopedic surgeon in Delhi.