#free medical journal

[biomedres]

Time Tested Practices for Mental Health Care During COVID-19 Epidemic and Beyond

Time Tested Practices for Mental Health Care During COVID-19 Epidemic and Beyond in Biomedical Journal of Scientific & Technical Research

The pandemic of Corona- virus (COVIT 19) has not only shocked the world but also changed it. None of the hit countries were nearly prepared to deal with magnitude of the impact of this plague [1,2]. People responded to the contagion in different ways. Some experienced fear, anxiety and over reacted. Others maintained a total disregard for protective measures [3]. The first type of response caused dearth of commodities in the market through overbuying, stocking piling and hoarding of goods, food items, sanitizers, masks and medicines. The second response caused the epidemic to spread with rapid speed [4] resulting in hundreds and thousands of death across the globe. No one knows for sure how the world would look post COVID 19 [2]. However, what is known is that the world would be dealing with the consequences of high mortality, psychological distress and mental chaos brought on by the epidemic of Coronavirus [5]. The impact of COVID 19 on the global markets, professional work, economy, and health care systems has adversely impacted the mental health of people across the world [2]. The situation is further exacerbated by minimizing social interaction to curtail the spread of contagious disease through quarantining and social isolation [6]. A review of 24 studies revealed negative long lasting psychological consequences of quarantining including post trauma stress, anger and confusion [6]. Cases of domestic violence are reported to be on the rise and those vulnerable to it can’t escape due to quarantine [7]. Quarantines and social distancing may be stressful but these can’t be avoided in the times of epidemics as the spread of the contingent might be worst. Mental health practitioners predicted global increase in cases of anxiety and depression drug / alcohol use and abuse, sleep problems, self-harm and suicidal ideation [8,9].

For more articles in Journals on Biomedical Sciences click here bjstr

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[mysharona1987]

[hersurvival]

"take half a pill before bed for one week then increase to one whole pill" there on the label and i already know what i am in for, that transitory period of starting new medication.

this is all incredibly recent, february. i have been suffering through it all, 27 years, until i found myself crying at work because of "ocd tendencies" they say, i say, because put that way, it's not definitive, but a maybe.

and since february, i have lost myself in the haze six times. six. already. (and one abrupt withdrawl period as an experiment from one doctor which was ill-advised by every subsequent professional i have seen after). and tonight we risk another. for these unanswered for tremors.

they say before bed as it will "make me drowsy" and at first that was exciting, it is what i wanted, but as it gets later, as the light outside grows dimmer, i am scared of becoming tired.

"i have a phobia of sleep" she told me and i told her "i have been scared of my dreams since i was five." this past week i have been dying every night that my body, my brain, something, has been refusing to let me drift back, there is no peace. i didn't fall asleep until 930 this morning, phone in hand, an hour and a half of mismatched baggage under my eyes before another appointment in the city.

i have spent the last several months dreaming on schedule, waking every two hours, all night, dying, panicking, resetting my mind to hit replay. but i don't think i am ready for this, what if i get stuck, trapped, will i spend six hours experiencing the nothingness of death? is it worth it? there was a time in my life i could rest. wasn't there?

[taviamoth]

🚨 IOF soldiers directly opened fire on journalists, including the Al-Jazeera press crew, during the ongoing invasion of #Jenin, which is approaching its third day.

Al-Jazeera reports that its crew's hotel is currently besieged by the IOF. A worker at the hotel where journalists are staying was wounded by IOF gunfire, and the IOF has demolished the guard room of the hotel.

At this moment, the IOF is sending reinforcements towards the hotel where press crews are staying.

[sensitivedead]

HELP. if anyone knows how to freely obtain this article pls let me know! I am specifically looking for the english written article by Maurice Ducosté (the link is to this specific 1938 article, I haven’t yet found a link but read elsewhere that he wrote several papers in English, one in 1933 I’d also like to read but I cannot find a link on)

I have an account they want me to rent it but I’d like to 🏴‍☠️🏴‍☠️🏴‍☠️🏴‍☠️🏴‍☠️🏴‍☠️ AWARRG MATEY the article or inspect it and get the pdf file or smthn? I’d greatly appreciate any help 🫶

I am doing hobby reading on the history of Cerebral Impaludation and Lobotomies, specifically interested in Ducosté’s work and the link between him, Egas Moniz, and Walt Freeman and plan on web sharing things I find in my readings here!

[notyourtoday]

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[jcsmicasereports]

Acute kidney injury following exposure to a formaldehyde –free hair straightening products by Dr. Nabil Abu-Amer in Journal of Clinical Case Reports Medical Images and Health Sciences

ABSTRACT

Formaldehyde- free hair straightening products are hair smoothening solutions widely used by professional beauty salons. Formaldehyde-free hair straighteners do not technically contain formaldehyde, however they contain other chemicals such as glyoxyloyl carbocysteine which releases formaldehyde upon contact with heat. Moreover, its by-product glyoxylate may convert to oxalate, both compounds have potential nephrotoxic effect.

Case presentation: 41-year-old woman presented to the emergency room with weakness, nausea , vomiting and  stage three acute kidney injury according to Kidney Disease: Improving Global Outcomes acute kidney injury staging (KDIGO) shortly after exposure to formaldehyde - free hair straightening product, other causes of acute kidney injury were excluded such as preceding acute illness, drug history or others nephrotoxic agent exposure On physical examination the patient was pale, her vital signs were normal. The urine microscopy and serologic workup was not indicative. Kidney core biopsy reveal interstitial edema, acute interstitial nephritis and oxalate crystal nephropathy. Kidney function completely recovered after a short course of steroid therapy.

Conclusions: We present a case of severe kidney injury after exposure to hair straightening products branded as formaldehyde free but actually contain other chemicals products which release formaldehyde and other toxic chemicals when heated during the straightening procedure and  may cause systemic toxicity, particularly kidney injury. Different cosmetic products are widely in use, not all are under a tight regulation, and therefore it is important to raise the awareness of both medical teams and consumers of possible adverse health effects of different cosmetic products.

INTRODUCTION

Nephrotoxicity is defined as kidney injury due to toxic effects of chemicals. There are various forms of chemicals and drugs that may affect renal function in various mechanism including acute tubular necrosis (ATN), tubulopathy and electrolyte imbalance, acute interstitial nephritis (AIN), glomerular damage, crystal nephropathy, and thrombotic microangiopathy [1-3].

Formaldehyde- free hair straightening products contain potentially toxic chemicals other than formaldehyde. One potential such substance is glyoxyloyl carbocysteine, which is composed of glyoxylic acid, cysteine and acetic acid. Glyoxylic acid both releases formaldehyde when heated and is converted into either glycine by AGT1 (alanine:glyoxylate aminotransferase 1) or oxalate by glycolate oxidase in the human cell peroxisomes [4].

Formaldehyde is a colorless aldehyde poisonous gas at room temperature [5]. It is usually mixed with water and when the small fraction of soluble formaldehyde reacts with water, it quickly forms methylene glycol. For every molecule of free formaldehyde, 1,820 molecules of methylene glycol are formed [6]. Methylene glycol reverts back to free formaldehyde almost immediately upon contact with air or skin. Formaldehyde is thus absorbed through skin, eyes, and inhalation, and is eliminated through the urine [7-8]. During the hair straightening process, high levels of formaldehyde are found in samples of air taken from beauty salons [9] and in specimens of hairstylist workers skin [10-11].

In the kidney, formaldehyde has been reported to cause direct cytotoxic effect resulting in acute toxic tubular necrosis [12-13], and may also cause an immune system response leading to acute interstitial nephritis.

Another potential nephrotoxic component of hair straightening products is oxalate, which is an end product of glyoxylic acid.  Increased levels of oxalate promote calcium oxalate precipitation in various tissues including the kidneys, resulting in toxic injury.

Case presentation

A 41-year-old woman with a history of hypothyroidism and sleeve gastrectomy five years ago, presented to the emergency department with profound weakness, nausea and vomiting. Her symptoms began three days earlier, immediately after using a professional hair straightening formaldehyde- free product in a professional beauty salon.

On physical examination the patient was pale, her vital signs were normal, heart rate  was 66 bpm, blood pressure was 125/70 mmHg, she had no fever or respiratory distress and appeared euvolemic.

Laboratory investigations revealed a serum creatinine of 3.46 mg/dl (one year prior to the event Cr. value was 0.6 mg/dl), urea 77 mg/dl, and electrolytes, liver function tests, Beta human chorionic gonadotropin (β-hCG) and complete blood count were normal. Blood venous gases revealed: pH 7.375, HCO3 21 mmol/L and base excess 3 mmol. The anion gap and serum osmolar gap were normal. Urinalysis demonstrated leukocyturia +1 without hematuria or proteinuria.

During hospitalization urine output was normal, repeat urinalysis demonstrated leukocyturia +1 without hematuria or proteinuria, and Bence-Jones protein was negative. Urine microscopy demonstrated epithelial cells with few white blood cells without any casts or crystals. Renal ultrasound showed 14.4 cm bilateral echogenic, edematous renal parenchyma (shown in  Fig. 1).

A full serologic workup including hepatitis B and C, Human immunodeficiency virus (HIV), syphilis, antinuclear antibody (ANA) , Anti-double stranded DNA, Antineutrophil cytoplasmic antibody (ANCA), Anti-Phospolipid antibody (APLA) was normal except for a complement C3 level of 80 mg/dl (normal range 90-110 mg/dl).

On the 4th hospitalization day a renal core biopsy was performed. The histologic examination (shown in Fig. 2) was correlatd with  acute tubular necrosis, tubulo- intersitial nephritis and oxalate crystals . With the diagnosis of interstitial nephritis, the patient was started on prednisolone 1 mg/kg, one week later serum creatinine decreased to a level of 0.98 mg/dl.

A: Glomeruli were normo-cellular and without signs of active glomerular disease (arrow heads), tubules showed signs of diffuse tubular injury (black arrow) and tubules contained oxalate crystals (blue arrow). B:The interstitium showed edema associated with multifocal mixed inflammatory infiltration with multiple eosinophils and foci of tubulitis. C:There was one epithelioid granuloma. D:Tubules contained oxalate crystals (blue arrow) observed under polarized light-microscopy. Immunofluorescence analysis revealed C3 1+ in blood vessel walls only.

Discussion

This patient presents an unusual case of kidney toxic and inflammatory injury accompanied with oxalate deposition secondary to hair straightening product. In a literature review, only few cases [14-15] of acute kidney injury (AKI) following hair straightening formaldehyde- free product exposure were reported. All cases were reported after 2019. The spectrum of kidney injury following hair straightening ranges from mild to severe kidney injury requiring renal replacement therapy. The histopathologic changes reported mainly depicted severe acute tubular necrosis and acute interstitial nephritis.

Our patient presented with stage 3 AKI following hair straightening formaldehyde - free product exposure. Other causes of AKI were excluded such as preceding acute illness, drug history or other nephrotoxic agent exposure. Laboratory workup revealed leukocyturia +1, and ultrasonography was significant for enlarged edematous echogenic renal parenchyma. Kidney biopsy demonstrated acute interstitial nephritis, oxalate crystal precipitation and acute tubular necrosis. We speculate that the clinical presentation and the histopathologic changes directly resulted from exposure to the hair straightening formaldehyde- free product.

In reviewing the ingredients of the specific product used in this case, it included glyoxyloyl carbocysteine, glyoxyloyl keratin amino acid, propylene glycol glycerin, phenoxyethanol, ethylhexylglycerin disodium and other collagen, surfactant and fragrance components. We did not find evidence in the medical, pharmacological and chemical literature that any of these substances causes acute kidney injury other than glyoxyloyl carbocysteine.

Many hair straightening products are labeled as formaldehyde "free" but actually contain chemicals such as glyoxyloyl carbocysteine or methylene glycol which release formaldehyde and other toxic chemicals when heated, e.g the carbocysteine hair treatment represents the combination of glyoxylic acid + cisteine + acetic acid. Glyoxylic acid contains an aldehyde functional group, glyoxylic acid behaves as an aldehyde by  heating during the hair straightening process thus releasing high levels of formaldehyde gas exceeding the capacity of exposure[16]. On top of that, glyoxylic acid absorbed through the scalp may had converted to oxalic acid [17] which may precipitate in kidney tissue. It is possible that other components such as propylene glycol may cause osmotic renal injury. In this case, serum osmotic gap was not available since it calculated four days after exposure.

Conclusion

In conclusion, a case of severe kidney injury after exposure to hair straightening products branded as formaldehyde free is presented. This case highlights the sensitivity of the kidney to various environmental and commercial products, some of which have not been fully characterized or identified yet.

It is important to raise the awareness of both medical teams and consumers, of possible adverse health effects of different cosmetic products, including acute kidney injury, and perhaps promote tighter regulation of such products.

Statement of Ethics:

Ethical approval is not required for this study in accordance with local or national guidelines.

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available.

Conflict of Interest interests

The authors have no conflict of interest to disclose

Funding

No funding was obtained for this study.

Authors’ contributions

NAA, NZ, SM, PB, were involved in the clinical management of the patient.

NAA, MK, collected the data and wrote the first version of the manuscript.

NAA, NZ, MK, SM, PB approved the final version of the manuscript.

The authors read and approved the final manuscript.

Data Availability

All data that support the findings of this study are included in this article.

[music-for-them-asses]

I can't find that post of a shirt that says "I don't know what's wrong with me, but I have a list of medications that didn't help." But it's me!! Gonna start my new meds tonight lolol

Rexulti better fucking worth considering how fucking expensive it is 🤬

[biomedres]

Perioperative Technology “Fast-Track Anesthesia End Analgezia” in Children of Abdominal Profile

Perioperative Technology “Fast-Track Anesthesia End Analgezia” in Children of Abdominal Profile in Biomedical Journal of Scientific & Technical Research

To date, the ultra-fashionable “Fast-Track” tactics have also reached us as pediatric anesthesiologists and resuscitators. It’s time to change old stereotypes, schemes, methods and approaches. The new concept of “Fast-Track” in surgery was proposed by H Kehlet (1993). Fast-Track surgery (early accelerated rehabilitation after surgery) is the search and implementation of effective methods of treating surgical patients with minimal risk. The selection of anesthesia methods, minimally invasive methods of surgical treatment, optimal pain control and active postoperative recovery in Fast-Track surgery reduces stress reactions and organ dysfunction, significantly reducing the time required for a patient to fully recover. Purpose of the Study Implementation of the concept of “Fast-Track” in the perioperative stage of treatment of children with abdominal pathology. Material and Research Methods A prospective-retrospective study with informed consent of the parents (legal representatives of the child) for the period 2014- 2019). The experience of using the Fast-Track technique began with abdominal patients. The main group (N = 42) - combined epidural anesthesia. Comparison group (N = 50) retrospective analysis of case histories - standard therapy of the perioperative period without the use of Fast-Track (endotracheal anesthesia, TBA).

For more articles in Journals on Biomedical Sciences click here bjstr

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[drsonnet]

There has as yet been no mention of the implications of the WNV (West Nile Fever) outbreak for the 2 million and more Gazans who are trapped in the enclave under conditions where the entire infrastructure has been demolished and access to healthcare, food, water and shelter are nonexistent. There is no way to implement standard public health precautions such as preventing formation of standing water and widespread use of mosquito repellent. Gaza has become a breeding ground for infectious diseases, with the entire population made vulnerable to large scale epidemics of not just WNV, but flu, pneumonia, bacterial dysentery, cholera, polio, measles and meningitis. The International Rescue Committee (IRC) noted in mid-April that even if an immediate ceasefire were implemented, they expected nearly 12,000 people would lose their lives in Gaza as a result of disease. And if the genocidal campaign persisted, nearly 90,000 could die of secondary health impacts. Dr. Seema Jilani, Senior Health Technical Advisor for Emergencies, observed, “With Gaza’s health system decimated by Israel, diseases once easily controlled are now spreading, and children, especially malnourished children, are the most susceptible. Projections suggest that the spread of cholera, measles, polio, and meningococcal meningitis pose a mortal threat … Immunity, previously ensured thanks to high levels of vaccination, is now decreasing especially among children and babies, who have now missed multiple doses of key vaccines including Hepatitis B, polio, and rotavirus.” Jilani added, “Respiratory infections and other endemic infectious diseases are currently widespread due to exposure, overcrowding in shelters, lack of access to proper sanitation facilities, and inability to access treatment. The IRC and partners working in Gaza have seen children die from diarrhea—affecting children at rates 25 times higher than before October 7th—otherwise easily treated with fluids and antibiotics. Half of the over 330,000 respiratory infections reported from October to January were children under 5, many of whom might face fatal or debilitating consequences given the current state of health care in Gaza.”

West Nile fever epidemic in Israel - World Socialist Web Site (wsws.org)

[peachesnabsinthe]

I made infused (and not infused) Banana-Blondies today 🌿💨🍌 They are also gluten free and dairy free. I forgot to take a photo of the cannabutter though 🥲

[lyraeon]

oh my god I'm so angry right now

I finally decided to look up the negative reaction I had to Zofran that made the ER doc mark it down as an "allergy" last month as soon as he connected the dots.

turns out that a likely explanation for me being super, unbearably, painfully, I nearly fell off the cot multiple times, *squirmy* on top of having a bad fever, severe confusion, no ability to regulate temperature so I was shivering and sweating at once, and being at the mercy of my digestive system...

well I mean I know most of that sounds like heatstroke, but that unbearable restlessness was the part that the doctor was like "oh yeah like 1:200 have this, let me get you something for it and mark this down as don't have" (and then I failed to realize the nausea meds I had at home were the same drug until after the next hospitalization lol).

anyway yeah. seratonin syndrome. potentially. because I was also on SSRIs and they injected me with a drug that stops nausea by blocking seratonin absorption.

which I feel like really should have been a med interaction that at least one of the like 14 assorted medical professionals who saw me in the last couple months could have had some foresight on. or that at least the doc who noticed the reaction should have realized it was.

like there's a chance it's not that, it's a different side effect, but I've been given Zofran before when I *wasn't* on SSRIs and if it had any effect on me it wasn't significant enough for me to remember, because I found that restlessness to be an entirely new kind of torture to me. the closest I can come to describing it was an itch, but not in the way the sensation was, just in the way it was insatiable no matter how much I tried to move to relieve it. it didn't hurt, it wasn't itchy, just. thrash inducing and fear inducing because nothing worked to make me feel like I could stay still. the doc said "kind of like anxiety?" when I was trying to describe it and while it wasn't the same sensation exactly, it was the same persistence, so that may be my best analogy.

anyway I'm typing this up half to bitch about this having happened and half to tell you that if you also take zofran at all maybe double check that some of your symptoms aren't being caused by the supposed solution.

(this isn't saying it's universally bad; all medications have pluses and minuses and I am not a doctor, pharmacist, or anyone else qualified to speak in general terms. I know others who it works great for. but I feel like the effects here were easy enough to mistake for my nausea-related stuff getting worse that I wanted others to potentially know it)

[wickedhawtwexler]

i get sooo worried about going off my adhd meds, but honestly i feel like i sometimes exaggerate how bad my adhd is because the last time i was unmedicated for a long period of time (right before i was diagnosed) i was also literally suicidal and had severe anxiety which uh. definitely exacerbated the lack of focus 🫠

[notyourtoday]

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[agreenroad]

Are Basic Freedoms Being Gained Or Lost?

MOST BASIC DEFINITION OF FREEDOM CONSISTS OF LIFE/LIBERTY, FREE WILL, FREEDOM OF THOUGHT How can a person tell when even the most basic forms of freedom are being lost, or has been lost? Life itself could be considered to be a form of freedom, but without other freedoms that go along with it, what is life really worth? If a person spends their entire life in prison or as a slave, how much…

[thetreetopinn]

My ADD Medication Journey - Dec 18, 2023

12/18/2023 – Monday

1st dose taken at 7:30 am

Packed a couple of granola bars in my lunch to snack on one or two hours after taking meds

Was noticeably fatigued waking up despite getting a proper night's sleep

Don't recall being woken up in the night, felt like I slept the whole way through

About an hour after taking meds, noticed slight increase in energy

Possibly because I've completely woken up

Two hours and energy is good, focus is good

Not noticing any increase in tremor intensity

I intend to try two doses today

Friday's 2 doses and sleep suggest that acclimating to the change in chemistry is required

Insomnia might be a temporary side effect

Will note my findings tomorrow

Unsure if this is related to the medication or if it's just a point in a cycle

Noticing reduced craving for soft drinks (usually Coke)

Convenience of access still provides temptation, but it isn't as strong

Been drinking water more than anything else

Possibly just at a point where I'm less interested in the sugary taste

Possibly no longer needing the stimulation due to the medication

Unsure, but will continue to monitor

Noticing suppressed appetite, still eating my granola bars to prevent low blood sugar

Noticed uptick in tremors after eating, not enough to be a hinderance

2nd dose taken at 12:30 pm

Originally intended to take medicine at 11:30 am, but got wrapped up in work

I should try to set a regular schedule for taking my medication and put in a daily reminder on my phone

Today was the office Christmas party and lunch was provided

Unsure if there was enough citrus in the food to affect medication absorption

Not noticing any major changes in tremor intensity – though the office being so cold doesn't help

Focus is still good, mood is still good

As of 2:30 pm, still not terribly hungry and doing well

The rest of the day passed without incident

Did not notice any increase in tremors

Energy and mood remained at a good level

Appetite was not terribly strong by the time I got home, but ate dinner anyway

Interested to see if I sleep like I did on Friday, or at all