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reasonsforhope · 6 months ago

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"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

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-video via University of Florida Health, May 1, 2024

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literaryvein-reblogs · 3 months ago

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how to write characters with muteness/mutism? (i hope i'm using the right words)

Both words may be used :) Mutism seems to be the more frequently used term in research and clinical settings.

Character Development: Mutism

Mutism - an inability or unwillingness to speak, resulting in an absence or marked paucity of verbal output

It is a common clinical symptom seen in psychiatric as well as neurology outpatient department

It rarely presents as an isolated disability and often occurs in association with other disturbances in behavior, thought processes, affect, or level of consciousness

The condition may also be voluntary, as in monastic vows of silence or the decision to speak only to selected individuals

Mutism occurs in a number of conditions, both functional and organic, and a proper diagnosis is important for the management

To write your character with mutism, you may want to begin with their backstory. Below are some types of mutism you could consider.

Types of Mutism

Selective mutism - having the ability to speak but feeling unable to, often because of social anxiety and debilitating shyness

Organic mutism - caused by brain injury, such as with drug use or after a stroke

Cerebellar mutism - caused by the removal of a brain tumor from a part of the skull surrounding the cerebellum, which controls coordination and balance

Aphasia - occurs when people find it difficult to speak because of stroke, brain tumor, or head injury

Additional definition: Selective mutism is characterized by a consistent failure to speak in social situations in which there is an expectation to speak (e.g., school) even though the individual speaks in other situations. The failure to speak has significant consequences on achievement in academic or occupational settings or otherwise interferes with normal social communication.

After determining the possible type/s and/or causes of your character's mutism, below are some characteristics and behaviours. Choose which ones are appropriate for your character. Also determine the frequency and the degree in which these occur.

Some Characteristics of People with Mutism

Social anxiety or shyness outside of the home

Silence that interferes with work or school

Mutism that can't be explained by trouble with language skills

Having experienced trauma

Suddenly becoming silent after speaking regularly

For organic or cerebellar mutism, not being able to speak despite wanting to

For aphasia, mutism can come with difficulty reading, telling time, understanding numbers, and writing

Being silent in social situations outside of the home

Paralyzing anxiety

Using nonverbal communication when spoken to

Asking others to speak for them

Interruptions in daily well-being because of mutism

Is caused by intense anxiety or social phobia

The symptoms interfere with school or work

Difficulty connecting

For Selective Mutism:

Ability to speak at home with family or people they are comfortable with

Fear or anxiety around people they do not know well

Inability to speak in certain social situations

Shyness

This pattern must be seen for at least 1 month to be called selective mutism. (The first month of school does not count, because shyness is common during this period.)

Note: In selective mutism, the child can understand and speak, but is unable to speak in certain settings or environments. Children with mutism never speak. Selective mutism falls under the "Anxiety Disorders" category.

Sample Case Report from this article

A 35-year-old married male was brought by police personnel with chief complaints of not speaking for the last 3 months. The patient had been under trial for the last 6 months for the alleged charge of setting fire in a cowshed. He would not interact with any of the jail inmates. He would however ask for food by non-verbal communication/gestures and would perform all his daily chores normally as reported. He was asked to follow up with family members. History reviewed from wife and elder brother reveled history of 18 years history characterized by violent abusive behavior, wandering behavior, irritability, decreased sleep, restlessness, muttering to self, and at times reporting that other would harm him, associated with withdrawn behavior and socio-occupational dysfunction. On one occasion, he became mute also and did not talk for a period of around 4 months associated with sadness of mood and decreased interest in surroundings. 6 months back, he had symptoms of muttering to self, would often roam about naked and get irritable on minor issues. No other significant history was obtained. MSE revealed decreased PMA, rapport not established, eye to eye contact could not be maintained, he was mute and would communicate nonverbally appropriately. His affect was blank with no facial expressions. All his routine investigations were within normal limits. A diagnosis of schizophrenia was entertained, and he was started on risperidone 6 mg per day and lorazepam 4 mg per day. Gradually the patient started showing improvement in symptoms.

Sources: 1 2 3 4 5 6 ⚜ Writing Notes & References

If this inspires your writing in any way, do tag me, or send me a link. I would love to read your work!

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mindblowingscience · 6 months ago

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A personalized vaccine for glioblastoma – the most aggressive and fatal type of brain cancer – has extended the survival of four humans in the first clinical trial of its kind. The newly fashioned medicine works by supplying the immune system with a way to 'recognize' the tumor and an 'instruction manual' for its entire transcriptome. This reveals where each and every gene in the tumor can be turned on or off. Equipped with such vital information, the immune system can reprogram the cancer's defenses and launch a more successful attack.

#Science #Medicine #Biology #Immunology #Oncology #Cancer #Brain Cancer #Vaccine #Vaccines

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dragonagitator · 9 months ago

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House MD fans: You wake up in the PPTH ER in summer 2004. What you doing?

Scenario parameters:

All your memories of the show and the past 20 years are intact.

You are stuck there/then and cannot return to our universe/year.

You have nothing but the hospital gown on your back.

Questions:

So, what do you do?

How much would you tell House?

How would you get him to believe you?

Who else would you tell?

How much would you tell them?

Inspiration:

The author self-insert isekai fanfic "Intervention" by VivatRex (aka @acrownforaking). They've been writing it for the past 11+ years and are still updating. It's already nearly 300k words long despite only being up to the events of S02E15. I AM IN AWE.

I haven't been able to stop thinking about this scenario ever since I read that fanfic a month ago. I'd love to discuss it with other House MD fans and hear what you would do.

(Apologies to the mutuals for the abrupt blog topic change. A new brainrot has taken hold.)

My short answer:

My long answers are below the cut.

So, what do you do?

My primary objective would be to enlist House in averting the pandemic.

My reasoning: If anyone can nip it in the bud before it gets out of Wuhan, I figure that a world-renowned genius doctor who is an infectious diseases specialist, speaks Mandarin, and now has a 15-year head start would have the best chance.

Difficulty level: Babysitting a narcissistic manchild with the self-preservation instincts of a toddler until the year 2020 so that he makes it there then alive, out of prison, and with his sanity, medical license, and professional reputation intact. To quote Quantum Leap, "Ohhhhhh boooooooy."

Strategy: I'm in the "I could fix him, but whatever's wrong with him is way funnier" camp, so I wouldn't try to change him (that always backfires anyway). Instead, I'd try to change his circumstances:

A stable romantic relationship would help, so I'd seduce him if I can (I'm not his type but a gal's gotta shoot her shot), try to get him together with Dominika earlier if I can't, and tell him how horribly his relationship with Cuddy ended so he knows better than to even start it.

Avert the shooting. Moriaty was a patient so his info is in the PPTH files. I AM THE ONE WHO KNOCKS. Or for a less murdery approach, try to get him arrested in April 2006 for violating New Jersey's strict gun laws.

Warn House about Tritter so he can switch patients with another clinic doctor.

Warn House to never get on a bus with Amber.

Tell Kutner I'm from the future and he's the only one who can prevent something horrible from happening (he's a Trekkie so he'll want to believe), then unfurl my big timeline poster and point at the "Kutner suicide early 2009" stickynote and ask him "so what's up with that, dude?"

Tell Wilson everything I can remember about his cancer -- he's an oncologist and thus can work backwards from there to figure out when to start checking for it so he can cut the tumor out while it's still just a tiny baby.

I would take a harm reduction approach to House's drug use, e.g., suggest that he try microdosing psilocybin and extend his liver's lifespan by substituting cannabis for some of his Vicodin and alcohol consumption.

Methods: Even though he doesn't have one for most of the show, House mentions a few times that he's entitled to hire an assistant, and I happen to be excellent at administrative work.

I think he'd be willing to hire me because working as his executive assistant / department secretary would position me to recognize patients as they come in so that I can discreetly pass along anything I remember, e.g., the kindergarten teacher has pork worms in her brain, ask the scientist in Antarctica to show you her feet, etc.

Meanwhile, I could lurk around the hospital preventing miscellaneous shit, e.g., get the gift shop volunteer from S01E04 to go home sick, ensure that the gunman from S05E09 is promptly admitted, diagnosed, and treated before he snaps and takes hostages, etc.

Possible sidequests:

Use my foreknowlege to get rich by milking online poker bonuses until the passage of the UIGEA in 2006, use my poker money to start flipping houses until 2007, get in on the "Big Short" in 2008, and set a Google Alert for "Bitcoin" so I can start mining/buying it from day one. Unfortunately, I haven't paid enough attention to individual stocks to play the market other than knowing that Amazon would be a good long-term buy & hold.

Use my riches to change the outcome of the 2016 election and try to steer the development of the internet and society in general in a slightly less stupid direction.

Send Pete Carroll a letter postdated just before the 2013 Superbowl telling him the outcome, then suggest for the final play of the 2014 Superbowl that the Seahawks try handing the ball off to Marshawn Lynch instead of throwing it because that throw will be intercepted. PRIORITIES.

How much would you tell House? How would you get him to believe you?

Your story about being from the future of an alternate universe in which House and everyone he knows are characters on a fictional TV show is already too batshit crazy to believe even without his kneejerk "everybody lies" skepticism. How would you differentiate yourself from all the patients who pull crazy stunts to try to get him to take their case?

My answer: For the "from the future" part, I'm hoping there's some sort of test that House could run to confirm that I was indeed vaccinated with a mRNA vaccine against the COVID-19/SARS-COV-2 virus. Given that neither of those things existed in 2004, that would be physical evidence that I'm not from around here now.

If producing physical evidence isn't possible, then I know that Vegetative State Guy from S03E15 is already a patient at PPTH because he'd been there for 10 years, so I'd find him and tell House about his son. I could also tell House enough about the cases from the first few episodes that I'm pretty sure he'd believe me by Christmas. I want in on Chinese food with Wilson.

I would wait until House accepted the "from the future" part before broaching the "fictional TV show" issue. Until then, "I watched a TV show about your life and cases" is a 100% true statement and it's not my fault if he assumes that show was a documentary. :)

Once he believed me, I'd tell him everything.

Who else would you tell? How much would you tell them?

There are people out there who would literally kill for your knowledge of the future, so going public or being too open about it seems highly risky.

My answer: I'd tell House, Wilson, and Chase right away. Kutner but not before Jan 2009. Maybe eventually Cuddy and the rest of the Diagnostics team if keeping my foreknowledge of the future from them proves too difficult.

House is the only one who gets to know everything. Everyone else is on a "need to know" basis.

I might also bring Bill Arnello (the brother/lawyer of the mob informant in S01E15 "Mob Rules") into the circle of trust because he could be a very useful resource for some of my sidequests, e.g., changing the outcome of the 2016 election far far far in advance and in the most direct way possible. (Hi, Secret Service! This is a purely hypothetical discussion about time travel and not at all indicative of any real criminal intent, pls do not pay me a visit, kthxbai.)

I think the only people I would tell the "fictional TV show" part to would be House, Wilson, and Chase, because there are things I need to warn them about that definitely wouldn't have been in a documentary. Like Chase needs to know that killing Diballa is 100% the right thing to do but he seriously needs to work on his OpSec. Everyone else gets the implied documentary lie of omission.

If I get caught knowing too much by random patients, I'll just claim to be psychic. Way more people believe in that than would believe in time travel.

What would you do?

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afeelgoodblog · 1 year ago

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The Best News of Last Week - June 13, 2023

1. U.S. judge blocks Florida ban on care for trans minors in narrow ruling, says ‘gender identity is real’

A federal judge temporarily blocked portions of a new Florida law that bans transgender minors from receiving puberty blockers, ruling Tuesday that the state has no rational basis for denying patients treatment.

Transgender medical treatment for minors is increasingly under attack in many states and has been subject to restrictions or outright bans. But it has been available in the United States for more than a decade and is endorsed by major medical associations.

2. Eagle Who Thought Rock Was an Egg Finally Gets to Be a Dad

A week after their introduction the cage where the little eaglet was put, was removed so the two could interact more closely. When they were given food, a whole fish for Murphy and bite-sized pieces for his young charge, rather than each eating their separate dish, Murphy took his portion and ripped it up to feed to the baby.

3. Little penguins to reclaim Tasmanian car park as city-based population thrives

Not far from the centre of Tasmania's fourth largest city, a colony of the world's smallest penguins has been thriving, and their habitat is about to expand into an existing car park.

The bright lights and loud noises of Burnie have not been a deterrent for hundreds of penguins who set up home on the foreshore in the north-west Tasmanian city.

4. Latest population survey yields good news for endangered vaquita porpoise

The resilient little vaquita marina appears determined to survive the illegal fishing that has brought it dangerously close to extinction, according to the latest population survey. Despite an estimated annual decline of 45% in 2018, the endangered porpoise appears to be holding steady over the last five years, according to a report published Wednesday by the International Union for Conservation of Nature.

5. 'Extinct' butterfly species reappears in UK

The species, previously described as extinct in Britain for nearly 100 years, has suddenly appeared in countryside on the edge of London. Small numbers of black-veined whites have been spotted flying in fields and hedgerows in south-east London. First listed as a British species during the reign of King Charles II, they officially became extinct in Britain in 1925.

This month they have mysteriously appeared among their favourite habitat: hawthorn and blackthorn trees on the edge of London, where I and other naturalists watched them flitting between hedgerows.

6. Colombian is a hero in Peru: he rescued 25 puppies that were about to die in a fire

During a structural fire that occurred in a residential area of Lima in Peru, a young Colombian became a hero. The Colombian, identified as Sebastián Arias, climbed onto the roof where the puppies were and threw them towards the community, that was waiting for them with sheets and mattresses. "I love them, dogs fascinate me," said the young man.

7. World-first trial for pediatric brain cancer

Researchers in Australia are conducting a world-first clinical trial for children diagnosed with ependymoma, a rare and devastating brain cancer. The trial aims to test a new drug called Deflexifol, which combines chemotherapy drugs 5-FU and leucovorin, offering potentially less toxic and more effective treatment compared to current options.

Ependymoma is the third most common brain tumor in children, and current treatments often lead to relapses, with a high fatality rate for those affected. The trial, led by researcher David Ziegler at the Kids Cancer Centre, has received support from the Kids with Cancer Foundation and the Cancer Institute NSW. The goal is to find a cure for every child diagnosed with ependymoma.

----

That's it for this week :)

This newsletter will always be free. If you liked this post you can support me with a small kofi donation:

BUY ME A COFFEE ❤️

Also don’t forget to reblog.

SUBCRIBE HERE for more good news in your inbox

#best news of last week

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lesbianfeminists · 2 years ago

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From heart disease to IUDs: How doctors dismiss women’s pain

Several studies support the claim that gender bias in medicine routinely leads to a denial of pain relief for female patients for a range of health conditions

One woman was told she was being “dramatic” when she pleaded for a brain scan after suffering months of headaches and pounding in her ears. It turned out she had a brain tumor. Another was ignored as she cried out in pain during a 33-hour labor. She was supposed to be getting pain medication through her epidural, but it had fallen out. Dozens of women complained of torturous pain as their vaginal walls were punctured during an egg retrieval process. They were told their pain was normal, but, in actuality, they were getting saline instead of anesthesia. These are just some of the stories of women who say their pain and suffering has been dismissed or misdiagnosed by doctors. Although these are anecdotal reports, a number of studies support the claim that women in pain often are not taken as seriously as men.

This year, the Journal of the American Heart Association reported that women who visited emergency departments with chest pain waited 29 percent longer than men to be evaluated for possible heart attacks. An analysis of 981 emergency room visits showed that women with acute abdominal pain were up to 25 percent less likely than their male counterparts to be treated with powerful opioid painkillers. Another study showed that middle-aged women with chest pain and other symptoms of heart disease were twice as likely to be diagnosed with a mental illness compared with men who had the same symptoms. “I was told I knew too much, that I was working too hard, that I was stressed out, that I was anxious,” said Ilene Ruhoy, a 53-year-old neurologist from Seattle, who had head pain and pounding in her ears. Despite having a medical degree, Ruhoy said she struggled to get doctors to order a brain scan. By the time she got it in 2015, a tennis ball-sized tumor was pushing her brain to one side. She needed surgery, but first, she rushed home, hugged her 11-year-old daughter and wrote her a letter to tell her goodbye.

Ruhoy did not die on the operating table, but her tumor had grown so large it could not be entirely removed. Now, she has several smaller tumors that require radiation treatment. She said many of her female patients have had experiences similar to hers. “They’re not validated with regards to their concerns; they’re gaslit; they’re not understood,” she said. “They feel like no one is listening to them.”

Doubts about women’s pain can affect treatment for a wide range of health issues, including heart problems, stroke, reproductive health, chronic illnesses, adolescent pain and physical pain, among other things, studies show. Research also suggests that women are more sensitive to pain than men and are more likely to express it, so their pain is often seen as an overreaction rather than a reality, said Roger Fillingim, director of the Pain Research and Intervention Center of Excellence at the University of Florida. Fillingim, who co-wrote a review article on sex differences in pain, said there are many possible explanations, including hormones, genetics and even social factors such as gender roles. Regardless, he said, “you treat the pain that the patient has, not the pain that you think the patient should have.”

Women say reproductive health complaints are commonly ignored

Women often cite pain bias around areas of reproductive health, including endometriosis, labor pain and insertion of an intrauterine device, or IUD. When Molly Hill made an appointment at a Connecticut clinic in 2017 to get an IUD, she said she was warned it would be uncomfortable, but she was not prepared for “horrific” pain. Hill, now 27 and living in San Francisco, recalled that during the procedure, she began crying in pain and shouted at the doctor to stop. “We’re almost done,” she said the doctor told her and continued the procedure. “It was full-body, electrifying, knife-stabbing pain,” she said. After it was done, she said she lay sobbing on the table in physical and emotional pain. “It felt violating, too, to have that pain that deep in your core where you feel the most vulnerable.”

Studies consistently show that women who have not experienced vaginal birth have much higher pain during IUD insertion compared with women who have given birth. A Swedish study found that among 224 women who had not given birth, 89 percent reported moderate or severe pain. One in six of the women said the pain was severe. Although numbing agents and local anesthetics are available, they are rarely used.

In some cases, women have sued physicians for ignoring their pain. Dozens of women sued Yale University claiming that during an egg harvesting procedure at its infertility clinic, they were supposed to be receiving the powerful painkiller fentanyl. But some women were getting only diluted pain medication or none at all, according to lawsuits filed in the state Superior Court in Connecticut. Later, the clinic discovered a nurse had been stealing vials of fentanyl and replacing the painkiller with saline solution. The nurse pleaded guilty last year and was sentenced for tampering with the drugs. One of the plaintiffs, Laura Czar, wrote about her experience for Elle magazine, describing it as “a horrible, gut-wrenching pain,” and told a doctor at the time, “I can feel everything you’re doing.” Despite her protests, the doctor continued. Yale said in a statement that it “deeply regrets” the women’s distress and has “reviewed its procedures and made changes to further oversight of pain control and controlled substances.”

Racial disparities in pain management

For Sharee Turpin, the pain of sickle-cell disease sometimes feels like tiny knives slicing her open. Sickle cell disease is an inherited blood disorder that can cause suffering so severe, its attacks are called “pain crises.” But when Turpin, who is Black, experiences a pain crisis, the 34-year-old does not rush to the ER in Rochester, N.Y. Instead, she combs her hair, mists some perfume and slips on her “Sunday best” in hopes that the doctors and nurses won’t peg her as a drug seeker, she said. Sometimes, Turpin gets a care team that understands her pain. Other times, she is treated as a bother. “I’ve even been told ‘shut up’ by a nurse because I was screaming too loud while I was in pain,” she said.

Abundant research shows racial bias in pain treatment. A 2016 study found half of white medical students and residents held at least one false belief about biological differences between Blacks and Whites, and were more likely to underestimate Black patients’ pain. “The management of pain is one of the largest disparities that we see between Black people and White people in the American health-care system,” said Tina Sacks, an associate professor at the University of California at Berkeley and author of “Invisible Visits: Black Middle-Class Women in the American Healthcare System.”

Labeling women “hysterical” or blaming psychological causes

Research shows men in chronic pain tend to be regarded as “stoic” while women are more likely to be considered “emotional” and “hysterical” and accused of “fabricating the pain.” Carol Klay, a 68-year-old from Tampa, had endured years of chronic pain from arthritis, degenerative disk disease and spinal stenosis. During a hospital stay last year, her doctor noted in her medical record that she was crying “hysterically.” Klay said she was crying because she was unable to sit, stand or walk without agony, and the doctor had removed morphine from her cocktail of pain medications. She wonders whether the doctor “would have called me hysterical if I was a man,” she said. Tampa General Hospital said it could not discuss specific patients, but stated: “Patient treatment plans, including medication orders to reduce pain, are prescribed by multi-disciplinary clinical teams.” Research shows women’s physical pain is also often attributed to psychological causes.

Jan Maderios, a 72-year-old Air Force veteran from Chipley, Fla., said the trauma of having pain dismissed by doctors has stayed with her for years. She saw about a dozen doctors in the early 1970s for pelvic pain. When clinicians could not identify the cause of her pain, she was referred to a psychiatrist.

“You start to doubt yourself after so many medical experts tell you there’s nothing wrong with you,” she said. After a hysterectomy in 1976, Maderios learned that fibroid tumors in her uterus had been the source of her pain. She said learning her pain was real — and physical — “made all the difference in the world.”

Why women’s pain complaints often aren’t taken seriously

During a 33-hour labor with her first child in 2011, Anushay Hossain, 42, of D.C., opted for epidural pain relief but said she still felt it all — every contraction, every cramp and every dismissal of her pain by her medical team. The doctor reassured her that she was getting the maximum dosage of pain medication.

In fact, she wasn’t getting any at all. She said her epidural had slipped out. By the time the error was caught, she was shaking uncontrollably and in need of an emergency Caesarean section, she said. “There’s a pain gap, but there’s also a credibility gap,” said Hossain, author of “The Pain Gap: How Sexism and Racism in Healthcare Kill Women.” “Women are not believed about their bodies —period.”

This pain gap may stem, in part, from the fact that women have historically been excluded from medical research. It wasn’t until 2016 that the National Institutes of Health (NIH) required sex to be considered as a biological variable in most studies it funded. “We’re making progress,” said David Thomas, special adviser to the director of NIH’s Office of Research on Women’s Health. “But we do have a long way to go because there’s this whole institutional approach to doing research — pain and beyond — where it tends to be male-focused.”

Nearly 95 percent of U.S. medical school students said instruction on sex and gender differences in medicine should be included in curriculums, according to a 2015 survey. But only 43 percent said their curriculum had helped them understand those differences and only 34.5 percent said they felt prepared to manage them in a health-care setting.

“It is changing, but it’s changing very slowly,” said Janice Werbinski, immediate past president of the American Medical Women’s Association and chair of the mentorship committee of the association’s Sex and Gender Health Collaborative.

How women can advocate for better pain care

It took decades to solve the mystery of Maureen Woods’s chronic pain. Woods, 64, of Myersville, Md., started having joint pain in her teens and, over the years, told dozens of doctors her pain was “debilitating,” she said. Some told her it was all in her head. In 2017, she was diagnosed with hypermobile Ehlers-Danlos syndrome, a connective tissue disorder often causing loose joints, dislocations and chronic pain. She said women who are not being heard should keep advocating for themselves. “You have to go with your gut — something is wrong and I need to find a doctor who can figure it out,” she said. Marjorie Jenkins, dean of the University of South Carolina School of Medicine Greenville, urged women against feeling pressured to accept an “everything is normal” non-diagnosis. “If your provider does not appear to be listening to you or believing what you’re saying, then you need a new provider,” Jenkins said. “You are the client, you are the customer and you are the owner of your health.”

Women can also take a family member, friend or other support person who can corroborate their stories, said Alyson McGregor, an emergency medicine professor at the University of South Carolina School of Medicine Greenville and author of the book “Sex Matters: How Male-Centric Medicine Endangers Women’s Health and What We Can Do About It.” Particularly in emergency departments, she said, there can be an inherent bias. “There’s this assumption that women are emotional and they’re anxious and that that’s the main issue,” she said.

#women’s health

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arctic-hands · 1 month ago

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I love my doctors and I have a great team don't get me wrong, but goddamn is the American healthcare system a fucking mess. It took THREE FUCKING MONTHS to conclusively determine that the polyp they removed in my last round of scopes was pre-cancerous. What if it had actually been cancerous? That's a three month fucking lag when time is off the essence with cancer.

When I had a brain tumor scare years ago, it took FOUR MONTHS to go from "you may have a brain tumor" to even MEET a neurologist, another week for an MRI, and another week to get the results back to tell me it's just another life-long illness. Like Jesus christ, every time I see those tweets by the American who was in Iceland and felt a lump in her breast, then was able to just walk into a cancer clinic the next Monday, get tested that same day, got results (negative) a few hours later, and only had to pay 4 krona, I see red from rage and green from envy.

#us healthcare

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insurrection-if · 7 months ago

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TW / Content Warning: death, loss, euthanasia

Apologies for oversharing after such a long period of silence, but tonight has cemented my thoughts towards this blog and its future status.

My eldest dog, Charlie, has passed away at the near age of thirteen. After his health scare in February, he had seemingly recovered and pepped back up to his usual goofy mama’s boy self. I am so thankful for these last several weeks I was able to enjoy with him, and feel so blessed to have seen him hold the strength that he did up until last night.

His condition plummeted rapidly and suddenly last afternoon. The veterinarians at the emergency clinic suspected a brain tumor yesterday, alongside (a) stroke(s), and confirmed this diagnosis just before he finally passed. We didn’t even have the time or money to undergo further testing to affirm what was then a theorized, tenuous diagnosis before it was clear that his time had come. It is confirmed to us now that cancer, not an infection, has likely been the main instigator of his health scare back in February. It’s a blessing that he didn’t suffer or dampen in his joy these past several weeks, up until yesterday, while afflicted with this illness.

Charlie used to be my great-grandfather’s dog. We took him into our home after my great-grandfather passed and his home was lost to our family. Charlie came to us in such poor health, and amazed us all with his recovery and clumsy energy these past two years. At that time, those most optimistic were projecting he only had a few months or so, and to see him having lived so long a full a life in the time he’s been under our roof (for far longer than anyone had foreseen) has been a wonder beyond comprehension. For the gift of his companionship, I cannot express enough of my gratitude.

I truly believe he’s in a better place. Goodness, I cried and prayed my heart out last night when I just absolutely felt in my soul what was around the corner - even when the clinic had then cleared him to come home and told us he would be fine. And even with all this time to be with him and give my goodbyes, it still doesn’t feel right to not have him walking into my room and insisting he be carried up to the bed all with a little wiggle of excitement in his hips.

These past few years were a good life for him. Even yesterday, when he began to show signs of and fall deep into weakness, confusion, and fatigue he still wagged his tail when I laid my hand on him and tried his best to follow the sound of my voice.

For those of you less interested in my personal matters and more so in just whatever content I can produce, this event has finalized some thoughts I’d been having a week or so before this in regard to this blog.

This is not a hiatus. Rather, this blog will be silent until I have a form of demo (‘short’ still in length) that I’m satisfied enough with to share. It’s been stressful balancing this guilt of not responding enough and the guilt of responding too much on this blog. And, with this great loss in my life, I don’t think I will regain the right headspace to manage this blog and my responses on it anytime soon.

Apologies for the silence and, now, the suddenness of this change in matters.

For all those with pets, whether they be full of health or struggling a little more with their once daily routine, please take the time to really show them all the love and care you hold for them each day. Please cherish your time with them, be kind to them, and form as many close memories as you can with them. It’s so easy to take time we have with them for granted. I’m so glad to have provided the home I did for Charlie, and hope he knows just I much I loved him and will keep loving him even now that he’s gone ahead of me to our next destination.

Again, apologies for becoming too personal with all this. The emotional wound is still so fresh and I simply hoped to vent as I clarified my current stance around this narrative. So many of you have been the absolute embodiment of gracious patience and abundant kindness with me and my nonsense here on this blog, and I thank you all deeply for it.

Here’s to hoping I return sooner rather than later with something good, or at least decent, to share.

See you soon.

#personal #tw: death #tw: loss

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