#medical news and technology

[reasonsforhope]

"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

-video via University of Florida Health, May 1, 2024

[reality-detective]

This is scary stuff, can you imagine what they are working on secretly.

"This is all available now.

This isn't science fiction."

Dr. Charles Morgan on Psycho-Neurobiology and War, How to operate a human via remote control. 🤔

[swtechspecs]

Imperial Department of Military Research IT-O Interrogator Droid

Source: The Essential Guide to Droids (Del Rey, 1999)

[greyedian]

oh my god I was thinking about a jayvik fallout new vegas AU and was like "hm maybe Viktor uploads himself into one of those robots until he can get a different body by like repurposing power armor or something idk" and then I remembered that this guy's name actually is Victor

[workersolidarity]

🇨🇳 🏨 🚨 CHINA IMPLEMENTS DRONE PROGRAM FOR BLOOD TRANSPORTATION IN SHENZHEN PROVINCE

📸 Photos from the implementation of a new drone transportation platform for blood transfusion emergencies at the Shenzhen Blood Center in Shenzhen, in the southern Chinese province of Guangdong.

The new program was implemented by the Shenzhen Blood Center and is seen here being used for the transportation of blood from the Shenzhen Traditional Chinese Medicine Hospital for the first time on Friday, January 19th, 2024.

Integrating both Artificial Intelligence (AI) and 5G communications technology, the new platform is said to help "ensure safety and improved efficiency of blood transportation," according to an article published in China's Xinhua News Agency.

#source

@WorkerSolidarityNews

[aurantia-ignis]

We have yet another "RANGER'S APPRENTICE MOVIE CONFIRMED AND COMING RIGHT UP!!" announcement I'll believe it when I see the trailers LOL

[reasonsforhope]

"A team of researchers at Washington University in St. Louis has developed a real-time air monitor that can detect any of the SARS-CoV-2 virus variants that are present in a room in about 5 minutes.

The proof-of-concept device was created by researchers from the McKelvey School of Engineering and the School of Medicine at Washington University...

The results are contained in a July 10 publication in Nature Communications that provides details about how the technology works.

The device holds promise as a breakthrough that - when commercially available - could be used in hospitals and health care facilities, schools, congregate living quarters, and other public places to help detect not only the SARS-CoV-2 virus, but other respiratory virus aerosol such as influenza and respiratory syncytial virus (RSV) as well.

“There is nothing at the moment that tells us how safe a room is,” Cirrito said, in the university’s news release. “If you are in a room with 100 people, you don’t want to find out five days later whether you could be sick or not. The idea with this device is that you can know essentially in real time, or every 5 minutes, if there is a live virus in the air.”

How It Works

The team combined expertise in biosensing with knowhow in designing instruments that measure the toxicity of air. The resulting device is an air sampler that operates based on what’s called “wet cyclone technology.” Air is sucked into the sampler at very high speeds and is then mixed centrifugally with a fluid containing a nanobody that recognizes the spike protein from the SARS-CoV-2 virus. That fluid, which lines the walls of the sampler, creates a surface vortex that traps the virus aerosols. The wet cyclone sampler has a pump that collects the fluid and sends it to the biosensor for detection of the virus using electrochemistry.

The success of the instrument is linked to the extremely high velocity it generates - the monitor has a flow rate of about 1,000 liters per minute - allowing it to sample a much larger volume of air over a 5-minute collection period than what is possible with currently available commercial samplers. It’s also compact - about one foot wide and 10 inches tall - and lights up when a virus is detected, alerting users to increase airflow or circulation in the room.

Testing the Monitor

To test the monitor, the team placed it in the apartments of two Covid-positive patients. The real-time air samples from the bedrooms were then compared with air samples collected from a virus-free control room. The device detected the RNA of the virus in the air samples from the bedrooms but did not detect any in the control air samples.

In laboratory experiments that aerosolized SARS-CoV-2 into a room-sized chamber, the wet cyclone and biosensor were able to detect varying levels of airborne virus concentrations after only a few minutes of sampling, according to the study.

“We are starting with SARS-CoV-2, but there are plans to also measure influenza, RSV, rhinovirus and other top pathogens that routinely infect people,” Cirrito said. “In a hospital setting, the monitor could be used to measure for staph or strep, which cause all kinds of complications for patients. This could really have a major impact on people’s health.”

The Washington University team is now working to commercialize the air quality monitor."

-via Forbes, July 11, 2023

-

Holy shit. I know it's still early in the technology and more testing will inevitably be needed but holy shit.

Literally, if it bears out, this could revolutionize medicine. And maybe let immunocompromised people fucking go places again

Also, for those who don't know, Nature Communications is a very prestigious scientific journal that focuses on Pretty Big Deal research. Their review process is incredibly rigorous. This is an absolutely HUGE credibility boost to this research and prototype

[reality-detective]

Novak showed an energetic disc from which he is inseparable. 🤔

Old Cathedral using the Schumann Resonance for healing since 1200s.

This is the main reason why you can feel godly presence in these ancient temples/churches, they are tuned into certain frequencies which are benefitial and healing for our bodies.

Ancient builders were masters of energy, vibration and frequencies! 🤔

[swtechspecs]

Darth Vader's Chest Box (Life Systems Computer)

Source: Star Wars Technical Journal (Del Rey, 1995)

[my-thoughts-and-junk]

anyway back to thinking about fionna and cake for the night because simon compels me

[malecaptions]

[another-dra-anew]

:angy: the fact i can’t talk about [redacted], a character who’s such a interesting culmination of how hopes peak and their system fails and neglects people, and also of how having a school like this has given people the opportunities to do great things which change lives, all because they’re a spoiler for something THAT IS LITERALLY [redacted] fucking GETS ME sometimes.

[mayankvikash]

#Cancer can be identified easily with the new #AI tool

https://mayankvikash.in/posts/Cancer-can-be-identified-easily-with-the-new-AI-tool/

[dead-generations]

One thing the yanks have us beat on is plan B. in australia for some inexplicable reason, pharmacies flatly to sell plan B to men though they do not make this policy known. They also will not tell a man attempting to purchase plan B that they won't sell it to men directly. It is seemingly universal and no one has ever given an explicable explanation, the one given at the point of refusal is typically "we need to let them know the side effects." I have genuinely no idea why this policy exists, as it is so universal I have a hard time believing that it is simply parochial control of women's bodies, and no explanation seems to exist in any regulation or guideline.

[drchristophedelongsblog]

Baby boomers are likely to be more demanding medically than their elders.

Several factors converge towards this trend

Level of education and information

Baby boomers are generally more educated and informed than previous generations.

They have better access to medical information and are more likely to seek quality care.

They are more likely to ask questions, challenge diagnoses, and seek alternative treatment options.

High expectations for quality of life

Baby boomers grew up in a period of prosperity and have high expectations for quality of life.

They are less willing to accept age-related limitations and are more likely to seek solutions to maintain their autonomy and well-being.

They have a proactive approach to their health, they want to continue being active for as long as possible.

Familiarity with technology

Baby boomers are more comfortable with technology than previous generations.

They are more likely to use digital tools to monitor their health, search for medical information and communicate with healthcare professionals.

They are more likely to use telemedicine tools or medical monitoring applications.

Awareness of patients' rights

Baby boomers are more aware of their rights as patients.

They are more likely to hold healthcare professionals accountable and seek recourse if something goes wrong.

The financial aspect

Baby boomers often have better financial situations than their elders, which allows them to have access to more expensive care.

Potential consequences

This increased requirement could lead to an increase in demand for health services, which could put a strain on health systems.

It could also stimulate innovation in the healthcare sector, with the development of new technologies and new approaches to care.

In conclusion, it is likely that baby boomers will be more demanding in terms of medical care than their elders, which will have important implications for health systems.

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