#prognostic factors

[persephoneflouwers]

Lewis Capaldi, you have ONE job tonight

[tanadrin]

I'm confused as to why you think Trump can be beaten. He only lost in 2020 because he was blamed for an unfolding catastrophe, and it was still a pretty narrow loss. In 2024 he can just point to how comparatively better everything was during his presidency and people will go along with it. None of his bad behavior or horrifying political aims means anything, because either people don't care, or the media doesn't care.

Well, for one I think he can be beaten because even the polls (which IMO underrated Biden) now show Harris ahead. For two, the Washington August jungle primary, which is a pretty historically useful leading indicator for the November elections, is consistent with a national environment that favors the Democrats. For three, the numbers that did show Trump ahead require you to believe some fairly odd things about the American electorate that have not been true in any recent election, including primary elections and special elections held so far this year. For four, while there are a lot of narratives about why Trump lost in 2020, I don’t think retro-prognostication based on a single factor is actually a cogent way to analyze elections. For five, his campaign is currently flailing, his VP pick is wildly unpopular, he got no convention bounce, and many voters seem thoroughly sick of him.

So yeah, I’m feeling pretty confident that doomers like you have no idea what they’re talking about. Harris could lose—hell, a gamma ray burst from a surprise supernova could sterilize the earth before November—but right now her odds are decent. She is, by most measures, even slightly favored.

Also I expect you to send me €300 for having to be yet another doomer’s Election Therapist. Unfortunately for you, I am not on the Krankenkasse, so I’ll need that by cash, bank transfer, or PayPal.

[covid-safer-hotties]

Emerging signs of Alzheimer-like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID-19 - Published Sept 29, 2024

Abstract Coronavirus disease 2019 (COVID-19) has been suggested to increase the risk of memory decline and Alzheimer's disease (AD), the main cause of dementia in the elderly. However, direct evidence about whether COVID-19 induces AD-like neuropathological changes in the brain, especially post recovery from acute infection, is still lacking. Here, using postmortem human brain samples, we found abnormal accumulation of hyperphosphorylated tau protein in the hippocampus and medial entorhinal cortex within 4–13 months post clinically recovery from acute COVID-19, together with prolonged activation of glia cells and increases in inflammatory factors, even though no SARS-COV-2 invasion was detected in these regions. By contrast, COVID-19 did not change beta-amyloid deposition and hippocampal neuron number, and had limited effects on AD-related pathological phenotypes in olfactory circuits including olfactory bulb, anterior olfactory nucleus, olfactory tubercle, piriform cortex and lateral entorhinal cortex. These results provide neuropathological evidences linking COVID-19 with prognostic increase of risk for AD.

[sysmedsaresexist]

DSM 5-TR Risk and Prognostic Factors for DID

Important DSM wording and description updates!

[dreaminginthedeepsouth]

Mike Luckovich, Atlanta Journal Constitution

* * * *

Why Ronna McDaniel’s hiring and “firing” by NBC matters.

March 25, 2024

ROBERT B. HUBBELL

Opening thoughts

In the span of 72 hours, NBC announced the hiring and partial “firing” of former Republican National Committee chair Ronna McDaniel. McDaniel’s hiring sparked a firestorm of protest within NBC internally and by viewers of MSNBC and NBC that caused the network’s executive to announce that she would not appear “on air” on the MSNBC cable network. (As of Sunday evening, it appears she will continue to appear on NBC as a political contributor.)

NBC’s decision to hire McDaniel was deeply troubling on many levels. The backlash by viewers and journalists at MSNBC and NBC was instructive and encouraging. But this story also serves as a morality tale for the challenges we will face in the next seven months as the media and pundits normalize and dismiss the attempted coup and insurrection.

Indeed, the hiring and partial retraction of McDaniel’s employment occurred amidst a renewed round of handwringing by pundits and consultants who are freaking out about the possibility of Biden losing in November. That fear is rooted in a stubborn refusal to acknowledge the stakes of the 2024 election and an obsessive compulsion with “favorability ratings.”

It’s a good thing none of those pundits or consultants were in charge of the Continental Army during the American Revolution when George Washington’s battlefield record was six victories, seven losses, and four draws. The modern-day pundits would have surrendered after the first loss, and America would be a colony of the United Kingdom today.

We will be forced to endure a constant barrage of defeatism from the political class in the months to come. Why? They are reserving their pre-emptive “I told you so” rights so that if things turn out badly, they can claim to be geniuses. If Biden wins, no one will remember or hold them accountable for their defeatism.  For the pundits, it’s a “Heads I win, tails you lose” proposition.

So, let’s burst the “I am a genius” balloons of the pundits now. The 2024 presidential election will be a close race. It takes no great skill or insight to wring your hands and say you have a bad feeling about the election. At this point, pundits and prognosticators are dead weight, holding back those of us who refuse to retreat at the first hint of trouble.

Most of the analysis by the self-proclaimed experts is incredibly superficial—about a quarter inch deep. For example, a reader sent me an “economic outlook” from the large Wall Street bank managing her retirement account. The Wall Street bank said that the markets are beginning to anticipate a Trump victory because Biden’s unfavorability ratings remain high.

The reader’s retirement advisers apparently do not understand that Americans actually vote for president and that elections are not determined by “favorability ratings.” Voters are not securities traded in an efficient market. They are people motivated by a multitude of factors.

The investment advisers do not appear to believe that women (or men) care about having their reproductive liberty controlled by religious zealots, allowing weapons of war to be carried in public without a permit, rolling back climate protections after the hottest year on record, disenfranchising Black voters, denying equal dignity to LGBTQ people, or allowing Americans to choose their leaders.

Nor do the investment advisers appear to be concerned that one of the candidates for president has 91 felony indictments, will sit through one criminal trial before the election, has promised to be a dictator, is threatening to blow up the strongest military alliance in the world, and appears (again) to be supported by Russia in his bid for the presidency.

We are in uncharted waters. Old maps do not apply. But pundits, pollsters, and Wall Street gurus insist on looking back to templates and spreadsheets that applied in “normal” times.

We are living through an exceptional moment in which we can make our own rules. Recognizing that fact and having the audacity to break “the old rules” to create a new template for success is critical to controlling the outcome of the 2024 election. Don’t allow yourself to be weighed down by consultants re-litigating the 1992, 2000, 2008, or 2016 elections.

I could go on, but you get the point. We control our destiny—but only if we ignore people who tell us we are sheep, shares of stock, or widgets. We are not. We are Americans wielding the awesome power granted us by the Constitution.

But how is Ronna McDaniel’s hiring and firing related to the shortsighted defeatism of the consulting class? Read on!

Rona McDaniel’s hiring illustrates the normalization of the insurrection and coup among the media and political class.

There is a direct line between normalizing the coup and panicking about Biden’s prospects in 2024. Hear me out.

Ronna McDaniel was aware of the fake elector's plot in real-time and did nothing to stop the attempted coup. Worse, she participated in a call to pressure local elections officials in Michigan to refuse to certify election results based on non-existent fraud. When the media reported on her participation in the election interference plot, she accused MSNBC of ‘spreading lies’ and employing ‘prime time propagandists.’” She repeatedly claimed that the 2020 election was “rigged.”

Regardless of whether Ronna McDaniel has criminal liability for the attempted coup, she cheered loudly for its success and smeared journalists who spoke the truth about the first-ever effort to prevent the peaceful transfer of power. That alone should ban her for life from any role at a legitimate news platform.

It is reprehensible that Comcast / NBC would hire Ronna McDaniel as a political consultant after her election denialism and active involvement in at least one overt act to overturn the Constitution. And yet, dozens of executives at NBC apparently view the attempted coup as part of the game of hardball election politics. They are ready to forgive and forget despite the lack of accountability for Trump and his advisers—including members of the RNC.

By reducing the attempted coup and insurrection to mere “partisan politics,” NBC is misleading the American people about the stakes in 2024 by denying the reality of what happened in 2020. And if you ignore the stakes, if you ignore the unprecedented nature of the 2024 election, then perhaps it isn’t unreasonable to say, “Well, in 1992, George H.W. Bush’s favorability ratings were X and he lost.” But Bill Clinton in 1992 isn’t Donald Trump in 2024. The world has forever changed because of the insurrection and the incipient fascism that is roiling beneath the surface.

We cannot allow NBC to continue in its misguided view of what is at stake in 2024. Read on!

The backlash against NBC was partially successful.

Hundreds of readers of this newsletter—and tens of thousands of Americans (an estimate) let NBC know that they strenuously objected to the presence of Ronna McDaniel on the network. Journalists at NBC and MSNBC also spoke out. The combined pressure worked—at least at MSNBC. See WaPo, Former RNC chair Ronna McDaniel faces sharp criticism after NBC hiring. (This article is accessible to all.)

According to WaPo, the president of MSNBC, Rashida Jones, sent an internal memo assuring MSNBC staff that Ronna McDaniel would not be forced on the hosts at MSNBC as an on-air contributor or commentator. Good! The pressure campaign worked.

But it is not enough.

McDaniel appeared on NBC’s Meet the Press on Sunday and attempted to dismiss her previous election denialism by saying that as chair of the RNC she “had to take one for the team.” One reasonable interpretation of that statement could be, “I lied because I was paid to lie.”

Chuck Todd was part of an NBC panel that dissected McDaniel’s interview on Meet the Press by Kristen Welker. Chuck Todd said,

Our bosses owe you [Welker] an apology for putting you in this situation because I don’t know what to believe. . . . I have no idea whether any answer she gave to you was because she didn’t want to mess up her contract. There’s a reason why there’s a lot of journalists at NBC News uncomfortable with this, because many of our professional dealings with the RNC over the last six years have been met with gaslighting, have been met with character assassination.

Good for Chuck Todd! (Not usually on my list of “go to” sources.) Let’s hope he speaks for a substantial portion of the NBC News staff—and that NBC management is listening.

The deluge of comments from listeners had an immediate effect on the editorial and staffing decisions at MSNBC! There is a lesson in that for all of us! We can fight the normalization of the coup and insurrection. Indeed, we must! Otherwise, voters will be misinformed about the stakes of the 2024 election.

There is more to be done.

As of Sunday evening, Ronna McDaniel appears to remain at NBC as a “contributor.” Thanks to a reader (Susan O. S.) for identifying the executives at NBC who oversee the news function at the NBC network (not to be confused with the cable-based MSNBC). The email addresses are:

President, NBC: Rebecca.Blumenstein@nbcuni.com

SVP of Politics: carrie.budoff@nbcuni.com

Keeping Ronna McDaniel “off the air” at a legitimate media outlet is imperative. She lied before she joined NBC and smeared NBC’s journalists for telling the truth. She participated in at least one act designed to overturn the election. She should not be trusted with any news platform that reaches persuadable voters—because we have no reason to believe that she will tell the truth going forward.

The stakes are simply too high, and the time is too short for NBC to “see what happens” if NBC “gives her chance.” McDaniel has proven who she is; we should believe her.

Let NBC know how you feel about its cynical willingness to play politics with our democracy.

[Robert B. Hubbell Newsletter]

[mcatmemoranda]

Rheumatoid Arthritis:

Refer to rheumatologist.

●Nonpharmacologic measures – Nonpharmacologic measures, such as patient education, psychosocial interventions, and physical and occupational therapy, should be used in addition to drug therapy. Other medical interventions that are important in the comprehensive management of RA in all stages of disease include cardiovascular risk reduction and immunizations to decrease the risk of complications of drug therapies.

●Initiation of DMARD therapy soon after RA diagnosis – We suggest that all patients diagnosed with RA be started on disease-modifying antirheumatic drug (DMARD) therapy as soon as possible following diagnosis, rather than using antiinflammatory drugs alone, such as nonsteroidal antiinflammatory drugs (NSAIDs) and glucocorticoids (Grade 2C). Better outcomes are achieved by early compared with delayed intervention with DMARDs.

●Tight control of disease activity – Tight control treatment strategies to "treat to target" are associated with improved radiographic and functional outcomes compared with less aggressive approaches. Such strategies involve reassessment of disease activity on a regularly planned basis with the use of quantitative composite measures and adjustment of treatment regimens to quickly achieve and maintain control of disease activity if targeted treatment goals (remission or low disease activity) have not been achieved. (

●Pretreatment evaluation – Laboratory testing prior to therapy should include a complete blood count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), aminotransferases, blood urea nitrogen, and creatinine. Patients receiving hydroxychloroquine (HCQ) should have a baseline ophthalmologic examination, and most patients who will receive a biologic agent or Janus kinase (JAK) inhibitor should be tested for latent tuberculosis (TB) infection. Screening for hepatitis B and C should be performed in all patients. Some patients may require antiviral treatment prior to initiating DMARD or immunosuppressive therapy, depending upon their level of risk for hepatitis B virus (HBV) reactivation.

●Adjunctive use of antiinflammatory agents – We use antiinflammatory drugs, including NSAIDs and glucocorticoids, as bridging therapies to rapidly achieve control of inflammation until DMARDs are sufficiently effective. Some patients may benefit from longer-term therapy with low doses of glucocorticoids.

●Drug therapy for flares – RA has natural exacerbations (also known as flares) and reductions of continuing disease activity. The severity of the flare and background drug therapy influence the choice of therapies. Patients who require multiple treatment courses with glucocorticoids for recurrent disease flares and whose medication doses have been increased to the maximally tolerated or acceptable level should be treated as patients with sustained disease activity. Such patients require modifications of their baseline drug therapies.

●Monitoring – The monitoring that we perform on a regular basis includes testing that is specific to evaluation of the safety of the drugs being; periodic assessments of disease activity with composite measures; monitoring for extraarticular manifestations of RA, other disease complications, and joint injury; and functional assessment.

●Other factors affecting target and choice of therapy – Other factors in RA management that may influence the target or choice of therapy include the disabilities or functional limitations important to a given patient, progressive joint injury, comorbidities, and the presence of adverse prognostic factors.

Osteoarthritis

General principles – General principles of osteoarthritis (OA) management include providing continuous care that is tailored to the patient according to individual needs, goals, and values and should be patient-centered. Treatment can be optimized by OA and self-management education, establishing treatment goals, and periodic monitoring.

●Monitoring and assessment – The management of OA should include a holistic assessment which considers the global needs of the patient. Patient preferences for certain types of therapies should also be assessed, as compliance and outcomes can be compromised if the care plan does not meet the patient's preferences and beliefs.

●Overview of management – The goals of OA management are to minimize pain, optimize function, and beneficially modify the process of joint damage. The primary aim of clinicians should include targeting modifiable risk factors. Due to the modest effects of the individual treatment options, a combination of therapeutic approaches is commonly used in practice and should prioritize therapies that are safer.

●Nonpharmacologic therapy – Nonpharmacologic interventions are the mainstay of OA management and should be tried first, followed by or in concert with medications to relieve pain when necessary. Nonpharmacologic therapies including weight management and exercises, braces and foot orthoses for patients suitable to these interventions, education, and use of assistive devices when required.

●Pharmacologic therapy – The main medications used in the pharmacologic management of OA include oral and topical nonsteroidal antiinflammatory drugs (NSAIDs). Other options include topical capsaicin, duloxetine, and intraarticular glucocorticoids. Our general approach to pharmacotherapy is described below.

•In patients with one or a few joints affected, especially knee and/or hand OA, we initiate pharmacotherapy with topical NSAIDs due to their similar efficacy compared with oral NSAIDs and their better safety profile.

•We use oral NSAIDs in patients with inadequate symptom relief with topical NSAIDs, patients with symptomatic OA in multiple joints, and/or patients with hip OA. We use the lowest dose required to control the patient's symptoms on an as-needed basis.

•We use duloxetine for patients with OA in multiple joints and concomitant comorbidities that may contraindicate oral NSAIDs and for patients with knee OA who have not responded satisfactorily to other interventions.

•Topical capsaicin is an option when one or a few joints are involved and other interventions are ineffective or contraindicated; however, its use may be limited by common local side effects.

•We do not routinely use intraarticular glucocorticoid injections due to the short duration of its effects (ie, approximately four weeks).

•We avoid prescribing opioids due to their overall small effects on pain over placebo and potential side effects (eg, nausea, dizziness, drowsiness), especially for long-term use and in the older adult population.

•We do not routinely recommend nutritional supplements such as glucosamine, chondroitin, vitamin D, diacerein, avocado soybean unsaponifiables (ASU), and fish oil due to a lack of clear evidence demonstrating a clinically important benefit from these supplements. Other nutritional supplements of interest that may have small effects on symptoms include curcumin (active ingredient of turmeric) and/or Boswellia serrata, but the data are limited.

●Role of surgery – Surgical treatment is dominated by total joint replacement, which is highly effective in patients with advanced knee and hip OA when conservative therapies have failed to provide adequate pain relief.

●Factors affecting response to therapy – The discordance of radiographic findings to pain supports the notion that the mechanisms of pain are complex and likely multifactorial. The placebo effect is also known to impact response to therapy.

●Prognosis – Although there is great variability among individuals and among different phenotypes of OA, courses of pain and physical functioning have been found to be predominantly stable, without substantial improvement or deterioration of symptoms over time.

[expertacademicassignmenthelp]

Diabetes

Introduction to Diabetes

Diabetes, a metabolic disorder characterized by chronic hyperglycemia, arises from abnormalities in insulin secretion, insulin action, or both. The condition’s prevalence has reached epidemic proportions globally, with significant health, economic, and social implications.

Types of Diabetes

Type 1 Diabetes: This autoimmune disease results from the destruction of pancreatic beta cells, leading to absolute insulin deficiency. Genetics and environmental triggers play pivotal roles in its pathogenesis. Despite being less common than Type 2 diabetes, its onset during childhood or adolescence significantly impacts individuals’ lives.

Type 2 Diabetes: Predominantly a disorder of insulin resistance, Type 2 diabetes accounts for the majority of diabetes cases worldwide. Lifestyle factors, genetic predisposition, and obesity contribute to its development. Its insidious onset often leads to delayed diagnosis and increased risk of complications.

Gestational Diabetes: Occurring during pregnancy, gestational diabetes poses risks to both maternal and fetal health. Hormonal changes and insulin resistance characterize its pathophysiology. Effective screening and management are crucial to prevent adverse outcomes.

Other Types of Diabetes: Variants like MODY, LADA, and secondary diabetes present unique challenges in diagnosis and management, requiring tailored approaches to care.

Epidemiology and Prevalence

Diabetes prevalence varies across demographics, with disparities observed in age, gender, ethnicity, and socioeconomic status. The escalating burden of diabetes underscores the urgent need for targeted prevention and management strategies.

Symptoms and Causes

Hyperglycemia-induced symptoms like polyuria, polydipsia, and unexplained weight loss serve as clinical indicators for diabetes diagnosis. Understanding the complex interplay of genetic, environmental, and lifestyle factors elucidates the condition’s etiology.

Complications

Diabetes complications encompass a spectrum of microvascular and macrovascular disorders, significantly impacting quality of life and life expectancy. From diabetic retinopathy to cardiovascular disease, nephropathy, neuropathy, and diabetic foot complications, the ripple effects of uncontrolled diabetes are profound.

Diagnosis and Tests

Accurate diagnosis relies on comprehensive evaluation, including fasting glucose, oral glucose tolerance tests, and hemoglobin A1c measurements. Screening recommendations aim to identify at-risk individuals early, facilitating timely intervention and risk reduction.

Management and Treatment

Diabetes management strategies encompass pharmacotherapy, lifestyle modifications, patient education, and multidisciplinary care. Individualized treatment plans address glycemic control, blood pressure management, lipid optimization, and prevention of complications.

Prevention

Prevention initiatives target modifiable risk factors through health promotion, public health interventions, and community engagement. Emphasizing the role of nutrition, physical activity, and behavioral changes empowers individuals to mitigate their diabetes risk.

Outlook and Prognosis

Prognostic factors such as glycemic control, adherence to therapy, comorbidity burden, and psychosocial support influence long-term outcomes. Enhanced collaboration among healthcare providers, policymakers, and stakeholders is essential to improve diabetes prognosis globally.

Living With Diabetes

Coping with diabetes requires resilience, self-management skills, and social support networks. Empowering individuals through education, self-monitoring tools, and peer support enhances their capacity to navigate the challenges of daily diabetes management.

Impact on Individuals and Society

Diabetes exerts a profound socioeconomic burden, encompassing healthcare costs, productivity losses, and reduced quality of life. Addressing the psychosocial dimensions of diabetes care is integral to fostering holistic well-being and societal resilience.

Future Directions and Research

Advancements in diabetes research, including precision medicine, digital health technologies, and novel therapeutics, offer promising avenues for disease management and prevention. Collaborative research endeavors aim to translate scientific discoveries into tangible clinical benefits.

Conclusion

In conclusion, diabetes represents public health challenge necessitating a comprehensive, patient-centered approach. By fostering awareness, promoting early detection, and advancing evidence-based interventions, we can mitigate the impact of diabetes on individuals, families, and communities worldwide.

Medical students encounter significant academic challenges during their studies, balancing coursework, clinical rotations, research, and personal commitments. Expert Academic Assignment Help offers tailored assistance to meet their needs, providing study materials, tutoring, assignment help, and exam preparation. Beyond academics, it fosters a supportive environment for mentorship and guidance. In essence, Expert Academic Assignment Help is a valuable resource for medical students, empowering them to excel academically and develop into competent healthcare professionals. Contact at expertassignment46@gmail.com for assistance.

[eugeniogalindo]

Staging of Leukemia

Unlike most solid tumors, leukemia is not classified by stage based on tumor size or spread. Different staging systems exist for each leukemia subtype. Overall, leukemia staging consists of multiple criteria including the type, count, and degree of maturation of specific blood cells, as well as the presence of enlarged lymph nodes.

Acute lymphoblastic leukemia (ALL) staging is based on the type and maturity of affected blood cells. The two main types of ALL are B-cell and T-cell ALL. Each type is staged according to the maturity of the blood cells. For example, B-cell ALL is classified as early pre-B, pre-B, common, or mature B-cell. T-cell ALL is classified as pre-T or mature T-cell.

There are two staging systems for acute myeloid leukemia (AML). The French-American-British (FAB) system consists of eight stages based on blood cell type and maturity. Stages M0 to M5 refer to cancers that develop from immature white blood cells like myeloblasts and promyelocytes. Stage M6 refers to acute erythroid leukemia, where malignancy originates from immature red blood cells, whereas stage M7 develops from megakaryoblasts, or platelet-forming cells. Alternatively, the World Health Organization (WHO) stages AML based on prognostic factors such as genetic abnormalities, comorbidities, and cellular differentiation.

Doctors can stage chronic lymphocytic leukemia (CLL) using the Rai or the Binet system. The Rai system is used in the United States. Comprising five stages, it assesses the severity of CLL based on three criteria: lymphocyte count, enlargement of lymph nodes, liver, or spleen, and development of blood disorders like anemia or thrombocytopenia. Rai stage 0, or low-risk CLL, is characterized by high lymphocyte count only, whereas stage 1 also includes enlarged lymph nodes. The liver or spleen may become enlarged in stage 2. Anemia and thrombocytopenia may develop in stages 3 and 4, or high-risk CLL.

In Europe, the Binet staging system focuses on enlargement of lymphoid tissue. Stage A describes CLL cases where some lymph nodes are swollen, stage B includes swollen lymphoid tissues in more than three areas, and stage C - like high-risk CLL in the Rai system - features anemia or thrombocytopenia.

The staging system for chronic myeloid leukemia (CML) is composed of phases that describe the number of immature white blood cells, also known as blasts, found in the bone marrow and bloodstream. Chronic CML is the earliest stage, where blasts account for less than 10 percent of total blood cells and patients present mild symptoms. In accelerated CML, blast growth progresses rapidly and results in more severe symptoms, such as weight loss. The most aggressive stage of CML is the blast phase, where blasts account for at least 20 percent of all blood cells and patients exhibit symptoms as severe as those with AML.

Doctors conduct various tests to accurately stage leukemia. They use diagnostic methods such as blood tests, bone marrow biopsy, and imaging modalities. A complete blood count, or CBC, determines the number of different cells in the bloodstream, and plays an important role in evaluating the severity of leukemia. Similarly, a bone marrow biopsy, taken from the patient’s hip bone, allows doctors to detect and identify the type of leukemia cells present in the bone marrow. Imaging modalities like x-rays and positron emission tomography (PET) scans can locate leukemia metastases in other parts of the body.

[chaoscoining]

🔥 How many special interests do you have at the moment?

🐒 What’s your favorite line from your special interest if it’s a video game/movie/tv show/etc?

✖️️ Is there something you don’t like about your special interest?

💖 Current special interest?

My main spin is psychology, with a secondary spin of LIOM. Honestly it's strange to me to see people gaining and losing spins, since mine are pretty lifetime.

I mostly dislike how misinformed people are, and how popular culture tends to misconstrue many disorders. I also really don't appreciate how little info we have on many disorders, and how many are taught about disorders clinically rather than as things real people and brains experience, preventing them from making connections that help people.

Monkey under the cute due to CW for traumatic experiences:

DSM-IV-TR, Page 334, under Dissociative Identity Disorder - Risk and Prognostic Factors

" Ongoing sexual, physical, and emotional trauma often leads to significant difficulties in later functioning. "

It's just so funny to me how blunt it is while being incredibly obvious. Like, damn, you think?

[biomedres]

Is Pentraxin 3 A Marker in Pathogenesis of Metabolic Syndrome?

Is Pentraxin 3 A Marker in Pathogenesis of Metabolic Syndrome? in Biomedical Journal of Scientific & Technical Research

Pentraxin 3 (PTX3) is an acute-phase protein that is structurally similar to C-reactive protein (CRP). Macrophages, endothelial cells, and adipocytes all produce PTX3 in response to inflammatory stimuli, but hepatocytes are the main source of CRP. PTX3 could play a role in the genesis of obesity, metabolic syndrome (MetS), and CRP because obesity and MetS are chronic inflammatory diseases [1]. MetS is a group of risk factors that includes glucose intolerance, abnormal lipid profiles, hypertension, and abdominal obesity [2- 6]. Each of these factors has been linked to atherosclerosis and cardiovascular disease. The majority of current research has found a link between MetS components and inflammatory mediators such as interleukin-6, tumor necrosis factor-α, and CRP [7]. Furthermore, serum CRP levels were shown to be greater in individuals with more risk factors for MetS, and higher serum CRP levels were related to higher occurrence of cardiovascular events, reflecting the prognostic relevance of MetS severity [8]. In particular, many types of cells, including macrophages, dendritic cells, neutrophils, adipose cells, fibroblasts, and vascular endothelial cells, have been reported to produce PTX-3, a newly recognized acute-phase reactant that is structurally and functionally similar to CRP [9]. The link between MetS and PTX-3 hasn’t been well investigated, and the available evidence appears to be discordant. Several investigations have found a link between MetS components and inflammatory mediators such as interleukin-6, tumor necrosis factor-α, and CRP [7]. The hs-CRP is the most well-known and validated of these inflammatory biomarkers. Insulin resistance, endothelial dysfunction, and unfavorable cardiovascular events have all been linked to high levels of hs-CRP [10,11].

For more articles in Journals on Biomedical Sciences click here bjstr

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[harshnews]

Neurological Biomarkers Market Size, Share, Trends, Growth and Competitive Analysis

"Neurological Biomarkers Market – Industry Trends and Forecast to 2030

Global Neurological Biomarkers Market, By Product Type (Genomics Biomarker, Proteomics Biomarker, Imaging Biomarker, Metabolomics Biomarker, Others), Indication (Spinal Muscular Atrophy, Parkinson's Disease, Schizophrenia, Huntington's Disease, Alzheimer's Disease, Depression, Multiple Sclerosis), Imaging Techniques (Transcranial Magnetic Stimulation, Diffusion Tensor Imaging, Conventional Structural MRI, Functional Magnetic Resonance Imaging, Positron Emission Tomography), Services (Sample Preparation, Assay Development, Biomarker Validation and Testing), End- User (Clinical Diagnostics, Pharmaceutical and Biotechnology Companies, Research Organizations) – Industry Trends and Forecast to 2030.

Access Full 350 Pages PDF Report @

**Segments**

- **Product Type**: The market can be segmented based on the product type into neurogenomics, proteomics, metabolomics, and genomics. - **Application**: Segmentation by application includes diagnostics, personalized medicine, drug discovery, prognostics, and others. - **End-User**: The market can be categorized by end-users such as hospitals, research institutes, diagnostic laboratories, and others.

Neurological biomarkers play a crucial role in the early and accurate diagnosis of various neurological disorders. The market is segmented based on several key factors that impact the demand and growth of neurological biomarkers. Product type segmentation includes neurogenomics, proteomics, metabolomics, and genomics, each playing a unique role in identifying biomarkers associated with neurological conditions. Application-based segmentation covers diagnostics, personalized medicine, drug discovery, and prognostics, highlighting the diverse utility of neurological biomarkers across different medical settings. End-user segmentation includes hospitals, research institutes, diagnostic laboratories, and other healthcare facilities that utilize neurological biomarkers for improved patient care and disease management.

**Market Players**

- **Thermo Fisher Scientific Inc.**: Thermo Fisher Scientific Inc. is a prominent player offering a wide range of neurological biomarker solutions for research and clinical applications. - **Merck KGaA**: Merck KGaA is a key market player known for its innovative neurological biomarker products and services aimed at advancing neurology research. - **Abbott Laboratories**: Abbott Laboratories is recognized for its contributions to the neurological biomarkers market through the development of cutting-edge diagnostic tools. - **F. Hoffmann-La Roche Ltd**: F. Hoffmann-La Roche Ltd is a leading player offering comprehensive neurological biomarker solutions for precision medicine and drug development. - **QIAGEN**: QIAGEN is a significant player providing high-quality biomarker technologies and assays for neurological research and diagnostics.

These market players are at the forefront of driving innovation and advancements in the field of neurological biomarkersThermo Fisher Scientific Inc. holds a prominent position in the neurological biomarkers market, offering a diverse range of solutions tailored for both research and clinical applications. The company's extensive portfolio encompasses neurogenomics, proteomics, metabolomics, and genomics products that cater to the specific needs of studying neurological disorders. Thermo Fisher Scientific's commitment to innovation and quality has solidified its reputation as a trusted provider of neurological biomarker solutions. By staying at the forefront of technological advancements and scientific research, the company continues to drive progress in the field of neurology.

Merck KGaA is another key player that stands out in the neurological biomarkers market due to its focus on delivering innovative products and services designed to advance neurology research. The company's dedication to developing cutting-edge neurological biomarker solutions has positioned it as a significant contributor to the market's growth and development. Merck KGaA's strategic collaborations and investment in research and development have enabled it to introduce novel approaches and technologies that have the potential to revolutionize the way neurological disorders are diagnosed and treated.

Abbott Laboratories has made substantial contributions to the neurological biomarkers market by pioneering the development of state-of-the-art diagnostic tools that aid in the early detection and management of neurological conditions. The company's unwavering commitment to improving patient outcomes through the provision of reliable and accurate neurological biomarker solutions has earned it a strong reputation in the industry. Abbott Laboratories' focus on leveraging scientific expertise and technological innovation underscores its dedication to addressing unmet medical needs in the neurology space.

F. Hoffmann-La Roche Ltd has established itself as a leading player in the neurological biomarkers market by offering comprehensive solutions that support precision medicine and drug development in neurology. The company's commitment to advancing neurology through the development of innovative biomarker technologies underscores its dedication to addressing the evolving needs of healthcare providers and patients alike. F. Hoffmann-La Roche Ltd's holistic approach to neurological biomarkers encompasses a wide range of applications, from diagnostics to ther**Global Neurological Biomarkers Market Analysis**

- The global neurological biomarkers market is witnessing significant growth attributed to rising prevalence of neurological disorders and increased investment in neuroscience research. - Genomics biomarkers segment is expected to dominate the market, driven by advancements in genomics technology and the ability to identify genetic markers associated with neurological conditions. - Alzheimer's Disease indication holds a substantial share due to the high prevalence of the disease globally and the urgent need for effective diagnostic and treatment solutions. - Imaging techniques such as functional magnetic resonance imaging and positron emission tomography are gaining traction for their ability to provide detailed insights into neurological conditions and facilitate personalized treatment approaches. - Pharmaceutical and biotechnology companies are the key end-users of neurological biomarkers, leveraging these tools for drug discovery, clinical trials, and precision medicine initiatives.

The global neurological biomarkers market is poised for substantial growth in the coming years, fueled by technological advancements, increasing disease burden, and growing focus on personalized medicine in neurology. Genomics biomarkers are anticipated to lead the market, supported by their ability to provide valuable genetic insights into neurological disorders and aid in the development of targeted therapies. The emergence of advanced imaging techniques like functional MRI and PET imaging is revolutionizing neurology by enabling precise diagnosis and monitoring of neurological conditions.

Alzheimer's Disease, a prevalent neurological disorder, is expected to drive significant demand for biomarkers, given the urgent need for early detection and disease management strategies. Pharmaceutical and biotechnology companies are investing heavily in neurological biomarkers for drug

Table of Content:

Part 01: Executive Summary

Part 02: Scope of the Report

Part 03: Global Neurological Biomarkers Market Landscape

Part 04: Global Neurological Biomarkers Market Sizing

Part 05: Global Neurological Biomarkers Market Segmentation by Product

Part 06: Five Forces Analysis

Part 07: Customer Landscape

Part 08: Geographic Landscape

Part 09: Decision Framework

Part 10: Drivers and Challenges

Part 11: Market Trends

Part 12: Vendor Landscape

Part 13: Vendor Analysis

Neurological Biomarkers Key Benefits over Global Competitors:

The report provides a qualitative and quantitative analysis of the Neurological Biomarkers Market trends, forecasts, and market size to determine new opportunities.

Porter’s Five Forces analysis highlights the potency of buyers and suppliers to enable stakeholders to make strategic business decisions and determine the level of competition in the industry.

Top impacting factors & major investment pockets are highlighted in the research.

The major countries in each region are analyzed and their revenue contribution is mentioned.

The market player positioning segment provides an understanding of the current position of the market players active in the Personal Care Ingredients

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[insightsbyskyquest]

Corporate Wellness Market Prognosticated For A Ravishing Growth By 2031

The Corporate Wellness Market outlook looks extremely promising is a valuable source of insightful data for business strategists. It provides the industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data. The research analysts provide an elaborate description of the value chain, future roadmaps and its distributor analysis. The forecast market information, SWOT analysis, Corporate Wellness market scenario, and feasibility study are the vital aspects analyzed in this report. The report also presents forecasts for Corporate Wellness investments from 2024 to 2031.

Global Corporate Wellness Market size was valued at USD 70.12 billion in 2022 and is poised to grow from USD 73.25 billion in 2023 to USD 103.94 billion by 2031, growing at a CAGR of 4.47% in the forecast period (2024-2031).

To remain 'ahead' of your competitors, request for a free sample PDF @ https://www.skyquestt.com/sample-request/corporate-wellness-market

The Corporate Wellness is segmented into the next classes.

Global Corporate Wellness Market is segmented on the basis of service, end user, category, delivery model, and region.

By service, market is segmented into Health Risk Assessment, Fitness, Smoking Cessation, Health Screening, Nutrition & Weight Management, Stress Management, and Others. By end user, market is segmented into Small Scale Organizations, Medium Scale Organizations, and Large-Scale Organizations. By category, market is segmented into Fitness & Nutrition Consultants, Psychological Therapists, and Organizations/Employers. By delivery model, market is segmented into Onsite, and Offsite. By region, the market is segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.

Profitable players of the Corporate Wellness market are:

Virgin Pulse Wellness Corporate Solutions ComPsych Corporation Provant Health Solutions Optum, Inc. EXOS Vitality Group Marino Wellness Truworth Wellness Sodexo (France) Wellness Layers TotalWellness Health Cerner Corporation Premise Health Kinema Fitness Fitbit, Inc. CoreHealth Technologies (Canada) Limeade LifeDojo RedBrick Health (US)

Regional Evaluation

The key regions covered in the Sports Drug Testing Device market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, U.A.E, etc.

Main features of the reports:

– Analysis and evaluation of strategic cooperation: researchers analyze recent strategic activities such as mergers, acquisitions, partnerships, collaborations and joint ventures. – Comprehensive Market Size Estimation: The report analyzes the demographics, growth potential, and capabilities of the Middle East and Africa market over the forecast period. This factor estimates the market size in Middle East & Africa and provides an insight into how the market will regain growth over the assessment period. – Investment Study: The report focuses on current and future investment opportunities in Middle East and Africa in particular, which will help stakeholders to recognize the current investment scenario in the market.

Read Corporate Wellness Market Report Today - https://www.skyquestt.com/report/corporate-wellness-market

The report provides vital statistics on the market status of major market players and provides insights into market trends and developments, growth drivers, technologies and changing investment structures in the global market. The reports use effective graphical presentation techniques such as graphs, charts, tables, and figures for better understanding.

Table of Contents

Global Corporate Wellness Market Research Report 2024-2031 Chapter 1 Corporate Wellness Market Overview Chapter 2 Global Economic Impact on Industry Chapter 3 Global Market Competition by Manufacturers Chapter 4 Global Production, Revenue (Value) by Region Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions Chapter 6 Global Production, Revenue (Value), Price Trend by Type Chapter 7 Global Market Analysis by Application Chapter 8 Manufacturing Cost Analysis Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers Chapter 10 Marketing Strategy Analysis, Distributors/Traders Chapter 11 Market Effect Factors Analysis Chapter 12 Global Corporate Wellness Market Forecast

[astronomyforastrologers]

October Surprises ~ 10 Oct 2024

October Surprises ~ 10 Oct 2024, Philip Sedgwick

Given the upcoming presidential election, pundits rabidly pontificate as to what could be this election cycle’s “October Surprise.” According to one uncannily successful political prognosticator, he has never allowed his predictions to be swayed by such surprises. This forecaster’s contention is that an accurate assessment of practical and relevant contributing factors permit clear forecasting, regardless of sweeping dramas and crises that seek to alter perceptions and fan histrionic reactions. Could it all be so simple and unsurprising?

Every year in the latter half of October our Sun, via conjunctions, does its thing to sow conscious attention on a series of superclusters and their components, regardless of the election cycle. Such transits seek to clarify the reality of circumstances mortals encounter, free of hyperbole, dramatic rendering and promotion of “don’t be left behind” scenarios. And every year these transits occur regardless of other planetary engagements in the solar system.

In fact, these solar > supercluster passages amplify and intensify the focus and the raw soulful motivation for full-on life supercluster engagement, providing access to enhanced consciousness and grounded insights. Every year this happens regardless of Pluto turning direct, or what aspects Venus or Mars form with gaseous giants, and even if Mercury is retrograde or not. Following is an assessment of these solar transits, which apply this year, will apply next year, and all years beyond no matter where other transits frolic.

20 Oct: Sun to Shapley Supercluster (28 Libra 27, epoch 2000.0)

This supercluster serves up the Libran consideration of all factors “to be fair” thing in spades. In fact, there is a potential to over weigh life’s evidence resulting in potential indecisiveness. The antidote is embedded within the instinct to rely upon deep internal desires, regardless of the attitudes dispensed by others. It is important to retain personal resolve rather than adopting societal or collective opinions that may not fit. Rely upon unique inner awareness and select options that best serves ones soulful interest.

The end result is that one more gracefully finds satisfaction with life’s results. In such satisfaction, the superclusters encourage engagement of life that exceeds the previous range of influence. Ones reach dramatically expands and within this reach a remarkable result often occurs. You likely share insights with others that they need but have not yet realized that they need. Should your insights seem rebuffed in the moment you present them, not to worry, they will be taken into account later, you can be certain. Meanwhile, ensure you apply all supercluster downloads to your efforts.

22 Oct: Sun to Centaurus-Hydra Supercluster (00 Scorpio 13, epoch 2000.0)

The Sun stands to illuminate this supercluster’s potential for cultivating wisdom and scholarly aspirations. This galactic congregation may locate adeptness in healing methodologies and demonstrate prophetic abilities. These traits receive broad amplification during this transit and may be grabbed by anyone, regardless of natal contact to this supercluster.

The ability to perceive how others are likely to respond in situations or to exposure to leading edge insight may appear to be founded in logic. However, it truly originates in the understanding of how people tick - ticking shared within supercluster information.

Mostly, the solar transit to this supercluster notes the need to combine all data, physical senses and indications that appear in life with instinctive emotional reactions resulting in decisions that truly align with ones higher objectives in life. The information appearing is sequential. It requires step-by-step processing and application. It’s like drawing a 3-d dot-to-dot picture in which the image revealed is surprising, enlightening and uplifting..

24 Oct: Sun to Shapley Attractor (02 Scorpio 21, epoch 2000.0)

For several days either side of this solar transit, note the urge to share all incoming insights without pontificating. Realize the insights have something useful and potentially profound to offer. Within the urge, step forward, move to the center of whatever group you find yourself in, and share insights with confidence.

There can be a sensation of being caught up, swept away or perhaps in over ones head. These sensations force a deeper examination of conditions at hand, no matter how strange those conditions are, and more to perceive naturally supportive influences and hidden attributes within every single condition that reveals an effective course of action.

Should life feel like a stalemate blocks the road, stand in front of a mirror. Ask yourself all life’s pointed questions. When done, without thinking, reply to each and every one of those questions. What comes out might be surprising and profound. It’s always a good idea to record any such sessions. When done assimilating, share all relevant insights.

30 Oct: Sun to Corona Borealis Supercluster (08 Scorpio 08, epoch 2000.0)

Here, the solar key is to recognize any solitary desires felt. If a person invokes their will for solitude, this is not alienation, exile or disenfranchisement by those from whom one takes their leave. Having space is different from being lonely. Choosing to step back from the maddening crowd is voluntary and contains no element of rejection. Being outside the fray is essential for impeccably clarity as to the meaning and importance of all life’s conditions. In reflective contemplation, one can decide what one intends to do to rectify unsatisfactory conditions all the while savoring all things satisfactory and more than satisfactory.

This transit coincides with the celebrations of All Souls. Combined, the transit and festivities seek to align the psyche with all choices selected on all levels of consciousness. Herein exists a fabulous portal to explore the subconscious and unconscious and whatever forms of metaconsciousness or hyperconsciousness one perceives to exist. Such exploration lands realizations, to be consciously applied here and here ever after.

As this transit of the Sun to this supercluster concludes, so does October. Those engaging the Sun-inspired awarenesses quickly decode those things that unexpectedly appear, include them into conscious processing and proceed through these weeks and beyond without the element of being caught off guard or imbalanced by any unexpected life variable.

More soon.

It’s getting to be the time of year when life becomes insanely busy. Should insight be desired and time be an issue, consider the half-hour consultation option. Easily, after the first of the year when seasonal influences abate, you can follow up with a full-hour session. If you would like to schedule a half hour now and a full hour in the first six weeks (or so) of next year, I am offering a package with a $35 discount to previous and new clients for this combo. Or you can do a stand-alone half-hour consultation, now discounted by $10.

These options will be included in the AstroMagia Interview link below. This package, like the video of the interview, will be offered only through 30 October.

If you experienced difficulty with the previous link to the AstroMagia interview, my apologies. Here is a verified link to get you to the right place to order the interview. A reminder that the interview will be available for viewing only through 8 November - ordering sooner is better.

For consultation packages, Galactic Reports, the Galactic Trilogy and more, please use the standard links that follow:

One Stop Shopping Order Form Astrological Texts

Meteoric the Movie on Vimeo ZAP! on Vimeo

[oziology]

Predicting Goals in the Fulham vs. Aston Villa Match: A Comprehensive Analysis

As a professional sports prognosticator, making accurate predictions involves analyzing a multitude of factors. Here’s a detailed breakdown of the expected number of goals in the upcoming match between Fulham and Aston Villa, based on recent data and trends.

Statistical Analysis

Fulham’s Home Games:

Average Total Goals: 2.90

Median: 3

Mode: 3

Aston Villa’s Away Games:

Average Total Goals: 3.00

Median: 3

Mode: 2

Last Five Meetings:

Average Total Goals: 2.60

Median: 3

Mode: 3

The consistency in the median and mode values around 3 goals suggests that this is a reliable prediction for the total number of goals in the match.

Team Motivation and Form

Fulham:

Currently 8th in the league, Fulham is motivated to climb the table.

Key players like Raúl Jiménez and Adama Traoré are in good form.

Full squad availability provides tactical flexibility.

Aston Villa:

Positioned 5th, Villa aims to break into the top 4.

Despite injuries to key players like John McGinn and Jacob Ramsey, Villa has shown resilience.

Strong performances from Ollie Watkins and Leon Bailey bolster their attacking threat.

Pitch and Weather Conditions

Weather Forecast: Partly cloudy with a temperature around 15°C and a 20% chance of rain.

Pitch Conditions: Likely to be dry, favoring a faster game with more accurate passing and shooting.

Recent News and Events

Fulham:

Strong start to the season with a mix of wins, draws, and a narrow loss to Manchester City.

Marco Silva’s tactical acumen has been a significant factor in their performance.

Aston Villa:

Dealing with injuries but maintaining strong form in both domestic and European competitions.

Unai Emery’s tactical expertise continues to drive their success.

Prediction and Betting Strategy

Predicted Total Goals: 3

Given the statistical data, team form, and other factors, predicting 3 goals in the match is reasonable. This aligns with the median and mode values and reflects the attacking capabilities and current form of both teams.

Suggested Bets:

Total Goals: 3

Alternative Bets: Over 2.5 goals, Both Teams to Score (BTTS)

Conclusion

While the prediction of 3 goals is well-founded, it’s essential to consider multiple factors and remain flexible. Diversifying your betting strategy and staying updated with the latest news can enhance your chances of making successful predictions.

[sysmedsaresexist]

From the DSM 5

Risk and prognostic factors for DID