#Pain Management Drugs

[scintillatingshortgirl19]

gee i wonder if the issue could be at all related to the fact that the current treatment plan for his chronic pain consists solely of FUCKING IBUPROFEN

[crazycatsiren]

My heart goes out to those who are struggling with opioid addictions and those who have died from overdoses.

It's not their fault that they wanted pain relief. It's not their fault that modern medicine remains lacking in pain management. It's not their fault that the American healthcare system is so messed up, and that insurance companies are nothing but greedy and awful. It's not their fault that they were given no options and could find no other ways out.

I love you. It's not your fault.

[laniidae-passerine]

I made my post about Dean Highbottom and then as I was writing my tags realised that his Hunger Games counterpart is Haymitch. and now my head is in my hands and I don’t think I’ll ever recover

[izzyspussy]

we went over the 14yr long torture session in my last therapy visit actually, and i told her that toward the end i was fantasizing about and then actively considering walking into traffic because if i got catastrophically injured then they would have to treat my pain. and she told me that's not an uncommon thing for people to do. that she has heard that many times before.

like think about that. we are so moralistic about drug use and have politicized a particular type of medicine so much, and doctors are so uncompassionate toward and even suspicious of patients who are in pain because of it, that it's NOT UNCOMMON for people who are otherwise not suicidal to start completely genuinely longing to get hit by a fucking car just for the chance to be oh so graciously provided the absolute bare fucking minimum of care.

think about how many different things have pain as a symptom. how many things have pain as the only symptom the patient is aware of. how many of them are life or death crises. heart attacks. blood clots. strokes. bleeding ulcers. those are just what i can think of off the top of my fucking head, AND I'M NOT A FUCKING DOCTOR.

what i had, for example, feels exactly like appendicitis. and they left it for fourteen years because my only symptom was excruciating pain and i didn't fit their stupid little (completely unsupported by evidence, btw) diagnostic mnemonic. if it had been appendicitis, or anything else as immediately deadly that "just" hurts, i would have fucking died the same night i got sent home from the emergency room with "medical" "advice" to take some tylenol and rest - for the first time, that is. out of dozens. how many people do die that way?

because addicts are Bad. and because doctors are too arrogant and biased to practice medicine on the basis of evidence and informed consent when the profit model and conservative propaganda make it soooo easy to stay in the good old days of paternalism instead.

[gingergofastboatsmojito]

Guys, I’m back on painkillers but this time I’m also writing. You’re sooooo in for such a ride 😈

[swamp-chicken]

at one point in time scar and bdubs had the PLEASE tell me you smoke weed conversation

[funkytrashsuperstructure]

moon smoking a fat blunt

[evil-jennifer-hamilton-wb]

Imagine taking 1500mg acetaminophen (500 within 6hr intervals) and a double dose sumitriptan

and it literately does absolutely nothing.

I guess time to figure out what the opiate market is like in the US

(/j for the last but, but I originally did start using opiates because my doctor refused to prescribe even a migraine med as simple as sumitriptan)

[neuroticboyfriend]

finally tried hydrocodone for my back pain and THIS is the ~big scary opioids~ they've been talking about?! i know they're still ykno, serious medication but. i. feel. fine! i even took my other medication todayy!? i'd be angry but im honestly just. WHAT. i'm not in pain! yall coulda gave me this YEARS ago but you just didnt! i shouldnt have had to have figured this out all on my own especially with how it coulda easily gone sideways if i didnt have some awareness of what im doing?? fuckkk the war on drugs man. fuck it. shit.

edit: to be clear no i am not prescribed this i found some in the house it aint mine

[kingproteus]

Doctors LOVE to prescribe opiates to a guy whose early childhood was destroyed by familial addiction issues. Like bro you’re the one telling me I have a lesion on my pituitary. Leave me alone or fix it stop giving me hydrocodone. Fuck off

[parasocial-work]

Seeing a lot of people on the internet saying ‘doctors are finally taking my pain seriously! It only took x years!’

And I just wanna say how a big factor in this is that doctors don’t think young people are capable of understanding their own pain.

You’re not just being taken more seriously for having X years of pain, or because doctors are finally more aware of pain management: you’re being taken more seriously because you appear to be more like an equal to them, a grown up person capable of understanding your pain.

Young people are suspect, foolish, unable to know their symptoms, falling for trends, possibly at risk of addiction: this unconscious prejudice is doubly or triply so if you’re a woman, or a person of colour.

But if you’re an adult, articulating themselves clearly and confidently as an adult does, they have a harder time knowing how to dismiss your pain.

[emiliosandozsequence]

the absolute worst thing bar none about my chronic pain is how irritable it makes me and how it makes me snap at people i love and say things i don't mean. i always apologize after, but jfc. i would rather not be like this so there would not even be a need.

[heich0e]

liv do you have any kids

god no and it's a good thing too bc my house is literally probably the least baby-safe place on earth

[cbirt]

In drug development, it isn’t easy to learn molecular representation from chemical structures since traditional molecular representation techniques, such as sequence-based and graph-based approaches, have limits in extracting useful vectors due to their extensive domain knowledge. Inspired by deep learning technologies based on images and computer vision, researchers have developed a self-supervised framework for learning picture representations that integrates protein and chemical image representations to accurately predict compound-protein interactions. IBM, Cleveland Clinic, and Kent State University have collaborated to create a drug discovery AI algorithm for treating chronic pain.

In the US, 50 million adults suffer from chronic pain, and 20% of people worldwide. Opioids, which are popular analgesics, have unfavorable side effects that include drug addiction. The need for less addictive non-opioid analgesics is highlighted by the opioid crisis. Since they cause intracellular signaling events in sensory neurons, G-protein-coupled receptors (GPCRs) are frequently targeted for pain management. Biased agonists of opioids or other GPCRs have been discovered recently to prevent negative effects. It is still difficult to identify unique chemotypes that produce analgesia without causing drug addiction side effects. There has been evidence linking the gut microbiota and its metabolites to the morbidity of chronic pain, with long-term pain being associated with a decrease in the amount of short-chain fatty acids.

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[thepandalion]

something something "character who is born into privilege but through circumstances relating to their birth has to suffer a pain they're helpless to preventing, and yet they don't stop trying to prevent the pain even knowing they cannot"