#Diabeti

[reasonsforhope]

"People living with diabetes might have a new hope. Scientists have tested a new drug therapy in diabetic mice, and found that it boosted insulin-producing cells by 700% over three months, effectively reversing their disease.

Beta cells in the pancreas have the important job of producing insulin in response to blood sugar levels, but a hallmark of diabetes is that these cells are either destroyed or can’t produce enough insulin. The most common treatment is regular injections of insulin to manage blood sugar levels.

But a recent avenue of research has involved restoring the function of these beta cells. In some cases that’s started with stem cells being coaxed into new beta cells, which are then transplanted into patients with diabetes. Researchers behind this kind of work have described it as a “functional diabetes cure.”

Now, scientists at Mount Sinai and City of Hope have demonstrated a new breakthrough. Previous studies have mostly involved growing new beta cells in a lab dish, then transplanting them into mice or a small device in humans. But this new study has been able to grow the insulin-producing cells right there in the body, in a matter of months.

The therapy involved a combination of two drugs: one is harmine, a natural molecule found in certain plants, which works to inhibit an enzyme called DYRK1A found in beta cells. The second is a GLP1 receptor agonist. The latter is a class of diabetes drug that includes Ozempic, which is gaining attention lately for its side effect of weight loss.

The researchers tested the therapy in mouse models of type 1 and 2 diabetes. First they implanted a small amount of human beta cells into the mice, then treated them with harmine and GLP1 receptor agonists. Sure enough, the beta cells increased in number by 700% within three months of the treatment. The signs of the disease quickly reversed, and stayed that way even a month after stopping the treatment.

“This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo,” said Dr. Adolfo Garcia-Ocaña, corresponding author of the study. “This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes.”

The results are intriguing, but of course being an animal study means there’s still much more work to be done before it could find clinical use. So far, harmine alone has recently undergone a phase 1 clinical trial in humans to test its safety and tolerability, while other DYRK1A inhibitors are planned for trials in humans next year.

Perhaps most importantly, the team will soon experiment with combining beta-cell-regenerating drugs with others that modulate the immune system. Ideally this should help overcome a major hurdle: the immune system will continue attacking new beta cells as they’re produced.

The research was published in the journal Science Translational Medicine."

-via New Atlas, July 14, 2024

[sherohu]

Si Parandalohet Diabeti - 6 Mënyra Natyrale

Si Parandalohet Diabeti – 6 Mënyra Natyrale

[eyfshaa]

Gece ne yaşamışım be

[mulderscully]

fantasizing about the kfc biscuit

[dinersaturn]

Mayblade day 9 - donut

Quick dragoon themed donut. I was originally going to do all of the main core that was an actually good drawing. However I’m sick as all heck so I quickly did this doodle and am going right back to sleep.

[gertlouw]

The easiest approach ever to deal with your OBESITY

Imagine yourself seated at the table, facing the reality for argument sake of weighing 200kg while aspiring to weigh 100kg. The problem is, the plate in front of you is designed to feed a 200kg (an rising) body. The core rule of this approach is to “FEED

[fnafagainstmodernfnaf]

You can stop repressing your thoughts about Roxy now, we get it

-👶

You personally disgust me, baby emoji anon. How dare you imply I love anyone other than my beloved super hot and sexy girlfriend (that I have). The thoughts that you have born from your mouthhole that now transcend to my mind through my mobile phone on tumblr dot com are revolting. I am violently throwing up and seizing (because I also have epilepsy) at the thought of even being ASSOCIATED with a fictional character so terrible. You’re lucky that you’re anonymous, baby emoji anon, because if you weren’t me and my super hot girlfriend (that I have) would find you.

-Mod Freddy Fazbear 🎩

[whicheveroneisthecoolest1]

My grandma is old Irish Catholic and has trouble managing her glucose levels as a type 2 diabetic.

She got one of these things that sends an alert if it’s too high or too low. We get them 4 am to 11 PM and it’s driving my mum crazy. My mum and I both get these alarms now, and we have very different ways of going about it.

My mum will always talk about life plans, and meal prep, and health concerns. My grandma, a lemony sort, simply rolls her eyes and eats fruit or candy or coffee and hangs up the second she’s done listening.

I on the other hand, shoot my grandma a message that goes something like this:

Me: Grandma, Jesus is calling. He says to eat some nuts.

Me: Jesus says, “Ms. Thang, nuts and veggies are your friends.”

Me: When the heart wants candy, spicy Jesus says that’s the devil talking.

Then I send her a gif of Da Vinci’s Twink Jesus bein ominous.

Guess what? 24 hours, no alerts. Gay, spicy twink Jesus has the right idea.

[bapydemonprincess]

I love knowing people who know I'm diabetic and I casually complain about anything wrong and they immediately like automatically go "Oh you should check your blood sugar. :)" WOW, THANK YOU. BECAUSE EVERYTHING IS CONNECTED TO BLOOD SUGAR NOW, AND IT'S SO OKAY TO BACKSEAT SOMEONE ELSE'S HEALTH PROBLEMS AS IF YOU KNOW SO MUCH ABOUT THEIR PROBLEMS! 😊😊😊😊

[houndpitspub]

I am really queen shit at thinking I'm faking being sick when I'm really not ok. Like I told my coworkers I didn't feel ok but it's probably nothing and now I'm bring sent home hehe 😅

[sherohu]

Diabeti i Tipit 2 - Shkaqet, Simptomat & Trajtimi

Diabeti i Tipit 2 – Shkaqet, Simptomat & Trajtimi

[lwieserce]

My sister suggested i might have diabeties 🧎

[eyfshaa]

Keşke 180 lerde olsanda kafam rahat uyusam

[gertlouw]

A revolutionary new approach

Yes, you can get that older body pain and aches under control, you can avoid cancer, you can have a radiant skin, you can get your energy and vigour back and much more! It is all possible with PLUS+. No magic hat trick but entrenched in science with proof

I want to share an exciting update with all of you regarding why I’ve been relatively quiet these past few months. The reason for my temporary absence has been a singular focus on the development of something truly extraordinary – the PLUS+ system. As we approach the much-anticipated launch date of October 1, 2023, I’m thrilled to provide some insights into what makes PLUS+ not only revolutionary…

[vamp1re-bite]

who will be my long distance boyfriend I bake into a cookie