#stem cell transplantation

[lifepulse]

Drug resistance in multiple myeloma: When cancer cells say "NO" to treatment

Drug resistance is like a game of cat and mouse. Cancer cells are the cat, and researchers are the mouse. The cat is always trying to find new ways to catch the mouse, but the mouse is always trying to find new ways to avoid getting caught.

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[anthonycrowley]

if you’re between the ages of 18-40 and are able please consider joining the bone marrow registry. it’s an easy way to potentially save someone’s life. (also, if you can’t donate blood it doesn’t necessarily mean you can’t donate marrow! mlm and trans people on hormones are encouraged to register as well!)

[bpod-bpod]

Blood to Brain

Bone marrow-derived (haematopoietic) stem cell transplants (HSCT), such as may be given for treating leukaemia, are being investigated as a means of delivering therapeutic proteins to the central nervous system. In this study, mice deficient in a protein called progranulin – mimicking the cause of neurological disease in humans – had levels restored by HSCT

Read the published research article here

Image from work by Pasqualina Colella and colleagues

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, July 2024

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[koifishart]

A window is a luxury for many patients. For many of them, instead of a window, video calls must suffice as the only contact with their family during many weeks of therapy in lockdown. Isolation, watching the changing, professional faces of the staff, a different drip every now and then connected to a tube sticking out of the arm. Solitude in the sterile whiteness, limited to a room with a bed and a bathroom. This is what the world of people with leukemia looks like. How do I know this? Because over a month ago, one of the most important people in my life received just such a diagnosis: acute myeloid leukemia. He has already undergone a series of chemotherapy, is slowly regaining strength, and is mentally and physically burdened. In the meantime, a donor of hematopoietic stem cells is being sought, which will hopefully bring him home permanently. We all wait, enjoying the smallest successes, such as getting out of bed or a successful game of ship games.

I would like to be a donor, but my health does not allow it. Therefore, I can only believe that somewhere in the world there is a person who is a genetic twin and will be willing to help. To register in DKMS, a cheek swab is enough. Just enough, and more than enough, to join the group of people who can give others a second life.

If you are out there somewhere, Twin, know now that I am very grateful for your help ❤️

[chronicillnesshumor]

On my Etsy store as a tee, hoodie, mug [ https://www.etsy.com/shop/ChronicIllnessTees?ref=dashboard-header ] or on RB as pin, sticker, magnet [ https://www.redbubble.com/shop/ap/167876916 ]

Black sweatshirt or t-shirt with "Mother Says It's My Turn With The Immunosuppressants"

[ahamkara-apologist]

Chewing on more trans hcs for Destiny, this time namely Drifter being trans but having gotten Golden-Age care and surgeries so the only indicator he's got is some scars at the base of his dick from his stem-cell generated penis transplant...one thing I love about magic scifi universes is the versitility in transition magic options that are out there lmao

[iamyouknow-yours]

Consider joining your local bone marrow registry!

You can save lives. If you're between 16 and 45, and generally healthy, please consider signing up.

The process of signing up is really easy, and if you're ever matched with someone to donate, the donation process is simple and painless.

https://sabmr.co.za/ <- that's the link to the South African registry.

https://www.dkms-africa.org/get-involved/become-a-donor <- you can also use DKMS if you prefer.

https://www.dkms.org/ <- if you're not in South Africa.

You sign up to the registry online (give them a bit of basic info and they check your eligibility, and then they'll organise a cheek swab).

Then anyone who needs a donation (such as some people with leukemia) has their marrow tested against everyone on the registry.

When they find a close enough match, the person is contacted.

If the person agrees to donate, their marrow is tested further, and if they're still a match, then the process is very simple.

The donor gets an injection for 5 days in a row, to increase the movement of stem cells from their bone marrow into their blood.

On the fifth day, blood will be taken, filtered through a machine to take the stem cells out, and returned to the donor.

They can go home on the same day.

Joining the registry does not mean you will donate, and if you do join and are contacted, you still have a choice.

There's no compensation involved, but often your expenses (such as travel) are paid. And you will incur no medical costs.

[venomgender]

3 months ago almost to this day we were told my cousins cancer was so bad she could pass at any moment and would need a miracle to survive... today shes stable celebrating her birthday.... it just feels really good

[covenawhite66]

The experiment involved little blobs of human brain stem cells tissue transplanted into rats. Then neurons integrated into the rat's brain so well the organoids started to respond to visual stimuli made of black and white images.

The experiment stopped after 3 months because of the rat rejecting human tissue despite the immunosuppressant medication.

The next experiment is to transplanting human brain tissue into adult rats with large cortical injuries, to see if they, too, can show functional integration

Brain organoids created from human pluripotent stem cells represent a promising approach for brain repair. They acquire many structural features of the brain and raise the possibility of patient-matched repair. Whether these entities can integrate with host brain networks in the context of the injured adult mammalian brain is not well established.

[moriparty413]

im in complete remission!!!! i kicked cancer's ass!!!!!!!!

[o-wyrmlight]

One of the squash plants stems split really badly and I wasn't sure about how to fix it. In the process of examining it, I ended up breaking the stem, so it doesn't matter now, anyway. So guess that plant's trashed now, huh.

[mylordshesacactus]

on endlings, and despair

Hey, y'all. It's...been a rough couple of weeks. So, I thought--better to light a single candle, right?

If you're familiar with wildlife conservation success stories, then you're likely also familiar with their exact polar opposite. The Northern White Rhino. Conservation's poster child for despair. Our greatest and most high-profile utter failure. We slaughtered them for wealth and status, and applied the brakes too slow. Changed course too late.

We poured everything we had into trying to save them, and we failed.

We lost them. They died. The last surviving male was named Sudan. He died in 2018, elderly and sick. His genetic material is preserved, along with frozen semen from other long-dead males, but only as an exercise in futility. Only two females survive--a mother and daughter, Najin and Fatu.

Both of them are infertile. They still live; but the Northern White Rhinoceros is extinct. Gone forever.

In 2023, an experimental procedure was attempted, a hail-mary desperation play to extract healthy eggs from the surviving females.

It worked.

The extracted eggs were flown to a genetics lab, and artificially fertilized using the sperm of lost Northern males. The frozen semen that we kept, all this time, even after we knew that the only living females were incapable of becoming pregnant.

It worked.

Thirty northern white rhino embryos were created and cryogenically preserved, but with no ability to do anything with them, it was a thin hope at best. In 2024, for the first time, an extremely experimental IVF treatment was attempted on a SOUTHERN white rhino--a related subspecies.

It worked.

The embryo transplanted as part of the experiment had no northern blood--but the pregnancy took. The surgery was safe for the mother. The fetus was healthy. The procedure is viable. Surrogate Southern candidates have already been identified to carry the Northern embryos. Rhinoceros pregnancies are sixteen months long, and the implantation hasn't happened yet. It will take time, before we know. Despair is fast and loud. Hope is slower, softer. Stronger, in the end.

The first round may not take. We'll learn from it. It's what we do. We'll try again. Do better, the next time. Fail again, maybe. Learn more. Try harder.

This will not save the species. Not overnight. The numbers will be very low, with no genetic diversity to speak of. It's a holding action, nothing more.

Nothing less.

One generation won't save a species. But even a single calf will buy us time. Not quite gone, not yet. One more generation. One more endling. One more chance. And if we seize it, we might just get another after that. We're getting damn good at gene editing. At stem-cell research. In the length of a single rhino lifetime, we'll get even better.

For decades, we have been in a holding action with no hope in sight. Researchers, geneticists, environmentalists, wildlife rehabbers. Dedicated and heroic Kenyan rangers have kept the last surviving NWRs under 24/7 armed guard, line-of-sight, eyes-on, never resting, never relaxing their guard. Knowing, all the while, that their vigilance was for nothing. Would save nothing. This is a dead species--an elderly male, two females so closely related that their offspring couldn't interbreed even if they could produce any--and they can't.

Northern white rhino conservation was the most devastatingly hopeless cause in the world.

Two years from now, that dead species may welcome a whole new generation.

It's a holding action, just a holding action, but not "just". There is a monument, at the Ol Pejeta Conservancy, where the last white rhinos have lived and will die. It was created at the point where we knew--not believed, knew--that the species was past all hope. It memorializes, by name there were so few, the last of the northern white rhinos. Most of the markers have brief descriptions--where the endling rhino lived, how it was rescued, how it died.

One marker bears only these words: SUDAN | Last male Northern White Rhino.

If even a single surrogate someday bears a son, we have erased the writing on that plaque forever.

All we can manage is a holding action? Then we hold. We hold hard and fast and long, use our fingernails if we have to. But hold. Even and perhaps especially when we are past all hope.

We never know what miracle we might be buying time for.

[indianmedguru]

Innovations in Leukemia Treatment: A Bright Future

Leukemia treatment is rapidly evolving with innovations like targeted therapy, immunotherapy, and stem cell transplants 🎯🧬. These advancements improve survival rates and quality of life🌟,offering hope for a brighter future 🌟. Personalized medicine and ongoing research continue to drive progress, bringing us closer to potential cures 🏥💙.