#stem cell transplantation

[lifepulse]

Drug resistance in multiple myeloma: When cancer cells say "NO" to treatment

Drug resistance is like a game of cat and mouse. Cancer cells are the cat, and researchers are the mouse. The cat is always trying to find new ways to catch the mouse, but the mouse is always trying to find new ways to avoid getting caught.

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[anthonycrowley]

if you’re between the ages of 18-40 and are able please consider joining the bone marrow registry. it’s an easy way to potentially save someone’s life. (also, if you can’t donate blood it doesn’t necessarily mean you can’t donate marrow! mlm and trans people on hormones are encouraged to register as well!)

[bpod-bpod]

Blood to Brain

Bone marrow-derived (haematopoietic) stem cell transplants (HSCT), such as may be given for treating leukaemia, are being investigated as a means of delivering therapeutic proteins to the central nervous system. In this study, mice deficient in a protein called progranulin – mimicking the cause of neurological disease in humans – had levels restored by HSCT

Read the published research article here

Image from work by Pasqualina Colella and colleagues

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, July 2024

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[koifishart]

A window is a luxury for many patients. For many of them, instead of a window, video calls must suffice as the only contact with their family during many weeks of therapy in lockdown. Isolation, watching the changing, professional faces of the staff, a different drip every now and then connected to a tube sticking out of the arm. Solitude in the sterile whiteness, limited to a room with a bed and a bathroom. This is what the world of people with leukemia looks like. How do I know this? Because over a month ago, one of the most important people in my life received just such a diagnosis: acute myeloid leukemia. He has already undergone a series of chemotherapy, is slowly regaining strength, and is mentally and physically burdened. In the meantime, a donor of hematopoietic stem cells is being sought, which will hopefully bring him home permanently. We all wait, enjoying the smallest successes, such as getting out of bed or a successful game of ship games.

I would like to be a donor, but my health does not allow it. Therefore, I can only believe that somewhere in the world there is a person who is a genetic twin and will be willing to help. To register in DKMS, a cheek swab is enough. Just enough, and more than enough, to join the group of people who can give others a second life.

If you are out there somewhere, Twin, know now that I am very grateful for your help ❤️

[ahamkara-apologist]

Chewing on more trans hcs for Destiny, this time namely Drifter being trans but having gotten Golden-Age care and surgeries so the only indicator he's got is some scars at the base of his dick from his stem-cell generated penis transplant...one thing I love about magic scifi universes is the versitility in transition magic options that are out there lmao

[iamyouknow-yours]

Consider joining your local bone marrow registry!

You can save lives. If you're between 16 and 45, and generally healthy, please consider signing up.

The process of signing up is really easy, and if you're ever matched with someone to donate, the donation process is simple and painless.

https://sabmr.co.za/ <- that's the link to the South African registry.

https://www.dkms-africa.org/get-involved/become-a-donor <- you can also use DKMS if you prefer.

https://www.dkms.org/ <- if you're not in South Africa.

You sign up to the registry online (give them a bit of basic info and they check your eligibility, and then they'll organise a cheek swab).

Then anyone who needs a donation (such as some people with leukemia) has their marrow tested against everyone on the registry.

When they find a close enough match, the person is contacted.

If the person agrees to donate, their marrow is tested further, and if they're still a match, then the process is very simple.

The donor gets an injection for 5 days in a row, to increase the movement of stem cells from their bone marrow into their blood.

On the fifth day, blood will be taken, filtered through a machine to take the stem cells out, and returned to the donor.

They can go home on the same day.

Joining the registry does not mean you will donate, and if you do join and are contacted, you still have a choice.

There's no compensation involved, but often your expenses (such as travel) are paid. And you will incur no medical costs.

[venomgender]

3 months ago almost to this day we were told my cousins cancer was so bad she could pass at any moment and would need a miracle to survive... today shes stable celebrating her birthday.... it just feels really good

[covenawhite66]

The experiment involved little blobs of human brain stem cells tissue transplanted into rats. Then neurons integrated into the rat's brain so well the organoids started to respond to visual stimuli made of black and white images.

The experiment stopped after 3 months because of the rat rejecting human tissue despite the immunosuppressant medication.

The next experiment is to transplanting human brain tissue into adult rats with large cortical injuries, to see if they, too, can show functional integration

Brain organoids created from human pluripotent stem cells represent a promising approach for brain repair. They acquire many structural features of the brain and raise the possibility of patient-matched repair. Whether these entities can integrate with host brain networks in the context of the injured adult mammalian brain is not well established.

[moriparty413]

im in complete remission!!!! i kicked cancer's ass!!!!!!!!

[o-wyrmlight]

One of the squash plants stems split really badly and I wasn't sure about how to fix it. In the process of examining it, I ended up breaking the stem, so it doesn't matter now, anyway. So guess that plant's trashed now, huh.

[samambaiababaia]

This website will point you towards how to become a stem cell/bone marrow (same thing) in so many different countries. I can’t recommend it enough.

Signing up to registry means that your country’s organisation will contact you if you are found to be a match for someone that needs a stem cell transplant (around 1 in 800 chance - which is why we need as many people as possible to sign up as potential donors!). You will only donate if you are found to be a match for someone.

The process is not as scary as ‘bone marrow donation’ makes it seem (which is why many places have switched to ‘stem cell donation’). In most cases, you will receive an injection that makes your stem cells migrate from your bone marrow into your bloodstream and then you will be hooked up to a haemodialysis machine that will filter your blood and take the stem cells out - this process does take several hours but, again, you will literally be saving someone’s life.

And afterwards your body will replenish the stem cells you donate - in as little as one week!

So please, please, please - look into signing up to your country’s stem cell/bone marrow donor registry.

Aww, remember this?

How cute are they?

Unfortunately:

I can't join the donor registry because I have Sjogren's (an autoimmune condition), can someone else join in my stead?

If you're not in the US, there are some other locations: https://www.abduld.com/azza

[gomediitechnologies]

How Much Does Bone Marrow Transplant Cost In Kenya?

Bone marrow transplant cost in Kenya lies between USD 14,000 - USD 31,000 (KES 2,170,000 to KES 4,800,000), depending upon the condition of patient and healthcare facility chosen.