#longevity activator

[fabiansociety]

the thing about blue prince if it really does have legs is that in five years it’ll seem almost quaint because enough of the puzzle twists will have filtered out into the culture. if nothing else the scope of the game will be known; you won’t have the vertiginous feeling that the world extends in every direction. it happened with myst, with dark souls, with every puzzle box game. at some point the space is just mapped thoroughly and you’ll see the game at gdq or wherever, played by people who don’t even parse anything the game is trying to say. it’ll stop being a mystery, and go back to being a toy. but now? when the answers aren’t available and the questions aren’t even known? that’s heady. anything could be in there, anything at all.

[unbfacts]

Hawaii has the highest life expectancy in the United States, with residents living an average of 80.7 years.

[darkwood-sleddog]

no i am not taking your unknown lineage, unknown temperament, unknown genetic health status malamute just because I have a pack of them. like please.

[peipakao]

various sonic and flash related tweets i made that i think are at least mildly amusing

[exeggcute]

deep in my heart of hearts I do think it's a little funny that everyone on this website has spent the last decade being actively hostile to any attempt tumblr has ever made to turn a profit (e.g. who remembers all of the "let's tank tumblr's value even more" jokes after the verizon > automattic sale) but now that tumblr is potentially entering its senescence people are acting legit surprised that its corporate owners aren't eager to shovel more cash into this money pit. idk why anyone would think the churning gears of capitalism would suddenly come to a halt and make an exception for a microblogging website started by a bunch of hipsters in 2007.

ultimately I do think tumblr suffers from having a userbase that's almost uniquely impossible to make money off of. I struggle to imagine any way this website could get out of the red considering that its users are generally resistant to ads (and running ads isn't super lucrative anyway unless you have a huge network and collect facebook/insta levels of audience data/PII, of which tumblr does neither. plus facebook/insta eliminates a lot of middleman fees because they are their own ad platform) and almost no one is gonna cough up money on a service they've been using for free for years. and before someone goes "well they should just make this website a public good and/or nationalize it" please go sit in the corner and spend some time coming up with (1) an honest forecast of how likely it is that'll occur in the next five years and (2) a list of steps that need to happen to get there and a list of resources necessary to keep it running afterwards. and before someone goes "I think tumblr should forget about profitability and keep the lights on indefinitely/focus on making users happy" please tell me what world you inhabit where everything runs on monopoly money and good intentions. I would love to visit someday.

[michyeosseo]

(´•̥ ᵔ •̥`)

update: cmg also posted complete with her own take on the hymg handholding encore and uhhhhhhh if the lord takes me today, so be it

[fitnesseddys-blog]

Functional Fitness Benefits: Get Stronger for Life

Standing in the gym, I felt out of place. People were lifting weights and doing complex moves with ease. I felt stiff, unbalanced, and even simple tasks were hard. But then, I found functional fitness1. Functional fitness isn’t just about getting strong. It’s about making your body ready for everyday life2. It uses exercises that are like real-life movements. This helps you get stronger, more…

[cobraonthecob]

i'm just. going to sneeze out some thoughts regarding junior drivers being arrogant enough to publicly like tweets regarding lance. the tl;dr is that everyone should get off of lance's back for being a pay driver and that every single celebrity should reduce the time they spend on social media interacting with fans and fan content, because as we have just seen with bianca, it turns into a very, very ugly situation and a reputation set on fire and thrown away

drugovich makes sense since he is aston martin's reserve driver would be called up to drive for the team should anything happen to fernando or lance. this is not to excuse him, and he should not be taking out his frustration on any driver (if i'm going to be spicy, maybe turn your ire to the driver who retired a few years ago and then came back), especially when said driver is in the same team as him and technically higher in rank. if anything, if he really wants to play his cards right, then he should wait until fernando finally retires, get the seat, and try to prove why he thinks he's better than lance (and then he makes rookie mistakes and the fans turn on him. that's just how it all goes for most rookies. do really well in feeder series and f1 throws lemons at you. george russell was a victim of this, as was mick. yes, horrendous cars, but fans are quick in changing their opinions on young drivers)

bianca however, makes no sense on why she would be frustrated about lance's presence in f1 unless there was a valid point to make about how financially inaccessible this sport is becoming (which none of the tweets from what i heard, did not talk about and only insulted lance). if we are to ignore everything else for a minute and put it in a vacuum, then bianca's frustration at lance having a seat at aston martin makes zero sense. bianca is currently in an f4 equivalent series and a midfield driver who should be focusing on becoming a better driver and a contender for top three, not liking tweets talking shit about a driver in a series way above her and in a team she is not backed by. like, let's say bianca does well next year, gets into an f4 series, does well there, rinse, repeat, and rise to the top, 2027 rolls around, she would be up against whether or not lando or oscar are still with mclaren or if they've moved to other teams or left f1 (let's just assume both of them are still there). she, as a rookie, would be going up against the talents of two drivers who have been with mclaren since 2019 and 2023, respectively. her concern should not be to a driver who is in a completely different team, but to proving that she is a capable driver

now back to actual context, there is no excuse for either drugovich or bianca liking anti lance tweets. that is extremely disrespectful from both of them, and i hope that this situation becomes a lesson to all junior drivers that the fans' eyes are on you and you have to distance yourself from the fandom. if aston martin or the fia really had a problem with lance, they can deal with it on their own.

[blueoaknx]

Reclaim Vitality: The Science Behind Mitochondrial Biogenesis

Mitochondrial biogenesis is the cellular process of increasing the number of mitochondria, the organelles responsible for generating energy. This process is essential for maintaining cellular health and vitality, particularly in tissues with high energy demands, such as muscles. Mitochondrial biogenesis is often triggered by increased energy demand, usually resulting from exercise, caloric restriction, or the intake of specific nutrients.

Mitochondria are the energy producers of the cell, generating ATP, the energy currency of the cell, through oxidative phosphorylation. As cells face greater energy demands, they need more mitochondria to meet these requirements efficiently. The increase in mitochondrial numbers allows cells to produce more energy and better adapt to stress, thus enhancing overall health, recovery, and performance.

Key Factors Involved in Mitochondrial Biogenesis

Several molecular regulators drive mitochondrial biogenesis, with the most important being:

PGC-1α ActivationPGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is recognized as the master regulator of mitochondrial biogenesis. This protein plays a pivotal role in controlling the transcription of nuclear genes that encode mitochondrial proteins. When activated by external stimuli like exercise, PGC-1α interacts with transcription factors like NRF-1 and NRF-2 to drive the production of new mitochondria. This results in increased mitochondrial DNA (mtDNA) replication and the synthesis of mitochondrial proteins necessary for energy production and cellular respiration.

AMPK & SirtuinsAMPK (AMP-activated protein kinase) is another critical regulator that responds to low energy levels within the cell (a high AMP ratio). It activates PGC-1α, which, in turn, increases the number of mitochondria. AMPK is activated during energy-demanding activities such as endurance exercise and fasting. Sirtuins (SIRT1) are a class of NAD+-dependent enzymes that also regulate mitochondrial biogenesis. Sirtuins, especially SIRT1, deacetylate PGC-1α, further activating it to promote the transcription of mitochondrial genes. Both AMPK and sirtuins respond to energy deprivation, whether through physical exertion or caloric restriction, helping cells increase energy efficiency and prolong cellular longevity.

Antioxidant Defense and Cellular ResilienceOne of the benefits of mitochondrial biogenesis is the enhancement of cellular resilience through improved antioxidant defences. Mitochondria are not only energy producers but also sources of reactive oxygen species (ROS), which can damage cells if not adequately managed. By increasing the number of healthy mitochondria, cells improve their ability to manage oxidative stress. New mitochondria are typically more efficient at energy production and less likely to produce excess ROS, reducing overall cellular damage. This process helps to protect cells from age-related decline and stress-induced damage.

How Mitochondrial Biogenesis Impacts Health and Performance

Mitochondrial biogenesis is essential for maintaining optimal energy production, particularly during periods of increased physical activity or stress. In muscle cells, the increased number of mitochondria leads to improved ATP generation, enhancing endurance and reducing fatigue during prolonged exercise. This is particularly important for athletes or individuals who engage in regular physical activity, as their muscles require a constant supply of energy for performance and recovery.

For general health, mitochondrial biogenesis supports metabolic efficiency and longevity. In metabolic disorders like type 2 diabetes and obesity, mitochondrial dysfunction often results in impaired energy metabolism and increased oxidative stress. By promoting mitochondrial biogenesis, cells can restore normal mitochondrial function, improving insulin sensitivity and energy balance. Furthermore, mitochondrial biogenesis may help reduce the risk of chronic diseases related to ageing by maintaining cellular energy production and reducing oxidative stress.

Beyond exercise and metabolic health, mitochondrial biogenesis is also a key factor in the body’s ability to adapt to various stressors, whether environmental or nutritional. The increase in mitochondrial capacity allows cells to better handle changes in energy demand, supporting recovery and cellular adaptation. For instance, during periods of caloric restriction, mitochondrial biogenesis helps the body use energy more efficiently, contributing to longer-term health benefits, including improved longevity and resistance to age-related diseases.

Supporting Mitochondrial Biogenesis with Nutraceuticals

In addition to lifestyle factors like exercise and caloric restriction, certain nutraceuticals can support mitochondrial biogenesis. Mitokatlyst™-E is one such product that targets mitochondrial function, optimising energy production, and promoting muscle recovery. By stimulating the molecular pathways involved in mitochondrial biogenesis, such products can enhance the body’s ability to adapt to stress, recover more efficiently, and improve overall cellular function.

Conclusion

Mitochondrial biogenesis is a vital process that supports energy production, cellular health, and adaptability to environmental and physical stressors. By regulating pathways such as PGC-1α, AMPK, and sirtuins, cells can increase mitochondrial content to meet higher energy demands, promote muscle recovery, and improve overall vitality. Products like Mitokatlyst™-E are designed to optimise mitochondrial function, helping the body adapt to stress and maintain optimal cellular health. By supporting mitochondrial biogenesis, we can improve energy efficiency, enhance physical performance, and promote long-term health and resilience.

[giveconsulting]

Immunization for Seniors: A Path to Health Preservation and Vitality

The Importance of Vaccines and Resources Available for Older Adults As we age, our health priorities naturally shift, placing greater emphasis on preserving well-being and living a long, fulfilling life. For seniors, immunization becomes a cornerstone of health maintenance, offering vital protection against common illnesses and serious health challenges. While vaccinations are frequently…

[mbarikiwax100]

From the Blue Zones to the Most Livable Cities: Lifestyle is a major contributor to longevity

In previous blogs we have covered quite a bit about the strong connection between nature, health and healing. It has been common knowledge for a long time that people live longer and healthier lives in those areas classified as Blue Zones, 5 geographical locations where nature plays a prominent role in longevity and lifespan. Hippocrates (460- 370 BCE, considered the father of medicine) almost…

[kanemedicalaesthetic]

Do Dermal Fillers Break Down Faster with Workouts or Facial Exercises?

Introduction Dermal fillers are widely known for enhancing facial contours, reducing wrinkles, and restoring volume lost with age. While their results are temporary, lasting anywhere from six months to over a year depending on the product and area treated, many patients wonder what lifestyle factors can influence longevity. One of the most common questions is whether regular workouts or facial exercises can make dermal fillers break down faster. This is especially relevant for fitness enthusiasts or those involved in high-intensity training who want to maintain their aesthetic results without compromise.

The Basics of Dermal Fillers and Longevity Hyaluronic acid-based fillers, such as Juvederm or Restylane, are the most commonly used types. They are gradually metabolized by the body over time, which is a natural and expected process. The rate at which fillers degrade can vary depending on the type of filler, the treatment area, the patient’s metabolism, and certain lifestyle habits. While there's no universally fixed timeline, most people begin to notice a reduction in volume between 6 to 18 months after treatment.

How Exercise Affects Metabolism and Fillers Exercise, particularly cardio or strength training, increases your overall metabolic rate. Since hyaluronic acid fillers are naturally broken down by the body’s metabolic processes, the idea is that a faster metabolism could speed up the breakdown of the filler as well. While scientific studies on this topic are limited, many practitioners and patients report that individuals with highly active lifestyles may notice their filler results fading a bit sooner than expected.

People who work out daily or have high-energy professions may be more prone to shorter filler longevity. This doesn’t mean you should avoid exercise altogether—maintaining physical health is essential—but it’s helpful to manage expectations and understand how your body might respond.

Facial Movements and Their Impact Facial exercises, also known as face yoga or facial muscle training, are another area of concern. These exercises typically involve exaggerated expressions or movements that are meant to tone facial muscles. Some proponents claim they help reduce sagging or improve facial tone naturally.

While these movements might help some muscle groups, they can also contribute to more rapid filler movement or dissipation, especially in high-mobility areas like the lips, nasolabial folds, and around the eyes. Repetitive movement can break down filler material faster, similar to how repeated use causes materials to wear down.

Areas Most Affected by Activity Not all areas of the face are affected equally by workouts or facial movements. For example:

Lips: Constant movement, talking, and facial expressions can make lip fillers degrade faster. Combine this with high metabolism, and lip fillers may last closer to 6 months rather than 12.

Under eyes: This area sees less movement, so filler tends to last longer regardless of physical activity.

Cheeks and jawline: These areas may last longer than lips but are still subject to the effects of high facial movement or muscle engagement during workouts.

Is Sweating or Heat a Factor? Another question patients ask is whether sweating or exposure to heat—like in saunas or hot yoga—can affect fillers. While normal levels of body heat from exercise are unlikely to dissolve fillers, extreme and repeated exposure to high heat immediately post-treatment may contribute to quicker breakdown. That’s why most providers recommend avoiding high heat environments for at least 48 hours after filler injections.

Tips to Prolong Filler Results While Staying Active You don’t have to stop exercising to maintain your filler results. Instead, consider a few practical tips:

Schedule touch-ups more frequently if you notice results fading sooner due to an active lifestyle.

Choose more robust or longer-lasting fillers for areas with high movement or metabolic activity.

Avoid aggressive facial massages or facial tools in treated areas unless recommended by your provider.

Stay hydrated and maintain a healthy skincare routine, as overall skin health can support the longevity of your results.

Balancing Aesthetics and an Active Lifestyle Ultimately, staying active and maintaining your health should never come at the expense of your confidence. If you’re someone who exercises frequently and notices faster filler breakdown, communicate this with your injector. They may adjust the type of filler used, the quantity injected, or the frequency of your touch-ups to better suit your lifestyle.

Conclusion While more research is needed to quantify the exact impact of exercise and facial movement on dermal fillers, evidence suggests that a high metabolic rate and frequent facial activity can contribute to faster filler degradation. This doesn’t mean you should give up your workouts or face yoga, but it does mean you might need to adjust your filler schedule accordingly. With the right guidance and a customized plan, you can continue to enjoy both your active lifestyle and long-lasting aesthetic results.

[too-much-boobus]

THIS IS NOT FUNNY GUYS how to become hot enough to justify being so so selfish how to not die AHGHHH AGHGGHHH I HATE HOMOSEXUALITY I HATE GAY PEOPLE AGGHHGGH literally my only weakness. can u imagine my power if i werent gay. i would die meaningless and alone but at least id know id been perfect by everyone else. i was not built for this i was built to be worshipped and yet here i am GROVELING like a PATHETIC FAGGOT because im WANTING SOMETHING which lends myself to VULNERABILITY AND GIVES THE POWER TO DESTROY ME TO SOMEONE ELSE. and WHAT ELSE AM I SUPPOSED TO DO. KILL MYSELF?1?1!1??1? maybe the problem is having self esteem. id say maybe its ok to be this pathetic as long as it makes them love me but it DOESNT EVEN. ITS ANNOYING AND BURDENSOME. i have to suppress myself if i want any of them at all. FUCK MY BAKA LIFE.and im GRATEFUL for this much but i cant help wanting more to the point the need and denial is interfering with my ability to enjoy anything. maybe buddha was right.........

holy shit i just reached the tag limit. anyways im gonna go take a fat shit and pray to god for a system reset soon plzplzplzplz i neeeed it i neeeed to reforge my identity from a depersonalized perspective chat come on its BEEN SO LONG what do i need to do.. ITS NOT MY FAULT NO ONES BEEN TRAUMATIZING ME LATELY come on now:/ i guess thats a good thing but i didnt know i was gonna turn into such a pissbaby afterward 😭 i hate the concept of regression how about im on top of it forever how about i never feel my emotions and never act my age THIS IS TOO SCARY IM SO BAD AT IT AHGHHHHH i will persevere. i just pictured a locked in chad face as a representation of myself and all my mortal complications have been quelled. Get back to work everypony crash out OVER. 😐🧏

#globs #♡

[thewisdomkeeper]

🌟 Discover groundbreaking secrets to maintaining senior independence and living vibrantly beyond 80! This comprehensive guide reveals why some seniors thrive while others struggle, backed by Harvard Medical School research showing that 80% of longevity depends on lifestyle choices, not genetics.

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Whether you're a senior yourself or caring for aging loved ones, this video provides practical, actionable strategies for enhancing vitality at any age.