#i got my first moderna dose today

[jcmarchi]

Commencement address by Noubar Afeyan PhD ’87

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Commencement address by Noubar Afeyan PhD ’87

Below is the text of MIT alumnus Noubar Afeyan’s Commencement remarks, as prepared for delivery on May 30.

Thank you, Mark, for that generous but somewhat embarrassing introduction.

President Kornbluth, trustees and faculty, students and families, guests, and members of this remarkable community of scholars and solvers: It’s a special honor to be with you today.

Graduates, I once sat where you now sit, brimming with excitement and the sense of accomplishment that comes with a hard-won MIT diploma. Congratulations!

Families, as the father of two MIT alums, I know first-hand the pride and emotion you feel today.

Faculty members, as a senior lecturer here for 16 years, I saw up close how well you prepare these graduates for what lies ahead. And fellow trustees, it is a great privilege to serve alongside you.

I spent my childhood in Beirut, Lebanon. Three generations of my proud Armenian family shared an apartment on the ninth floor of our building. The window in the bedroom I shared with my great aunt looked out over the red-tiled roofs of Roman, Ottoman, and Byzantine buildings and beyond to the Mediterranean Sea.

When civil war erupted in 1975 and the government imposed strict curfews, the state broadcaster often shifted from airing three hours of TV a day to offering round-the-clock programming of mostly American television shows, a diversion for my brothers and me when we were forced to stay inside.

One show in particular had me captivated. Just hearing the theme song would set my heart racing — perhaps you know it, too.

That’s right… “Mission Impossible”!

Even if you never saw the TV show, you likely know the movies with Tom Cruise as agent Ethan Hunt.

The encoded self-destructing message to the agent always began the same way: “Your mission, should you choose to accept it …”

No matter how long the odds, or how great the risk, the agents always took the assignment.

In the fifty years since, I have been consistently drawn to impossible missions, and today I hope to convince each and every one of you that you should be too.

Play video

Class of 2024, one incredibly challenging mission is already under your belt: You were given the assignment to begin your studies at MIT … without being at MIT. Going to college, without going to college, was not a mission you’d signed up for, but it is what you got. A handful of you did move to campus, but even for you, masking, testing, social distancing, and virtual classes meant orienting to a foreign land. You even learned a new language, as terms like “Q-week” and “SCUFFY” entered your MIT lexicon. No one knew what would happen next, or when it would all end.

And yet, you found ways to thrive. You dove into your coursework and started to build mostly virtual friendships. In the words of your classmate Amber Velez, who rented a Cambridge apartment with three MIT roommates, you “patched together a little lifeboat in this vast sea of students, spread out over the world.”

Earlier that year, just up the road in Kendall Square, my colleagues and I at Moderna had received another mission that seemed impossible: Develop a safe and effective vaccine that could save lives, restart the economy, and do so in less than a year. Oh, and while you are at it, get a billion doses manufactured, distributed, and into the arms of people around the world.

It was clear that if we accepted this challenge, it would take everything we had. We would have to slow 20 ongoing drug-development programs and focus on solving COVID.

We embraced the mission!

Just 48 hours after Moderna obtained the sequence for the SARS-CoV-2 spike protein, we deployed our mRNA technology to produce a potent vaccine. Less than two months later, we enrolled our first patient in a clinical trial, and on November 16th, the vaccine was determined to be 94.5% effective against Covid-19. By some estimates, Moderna’s vaccine saved over 2 million lives during the pandemic.

How did we do it? That’s another speech for another day.

But what I do want to talk about is what it takes to accept your own impossible missions and why you, as graduates of MIT, are uniquely prepared to do so.

Uniquely prepared – and also obligated.

At a time when the world is beset by crises, your mission is nothing less than to salvage what seems lost, reverse what seems inevitable, and save the planet.

And just like the agents in the movies, you need to accept the mission – even if it seems impossible. I know the odds don’t appear to be in your favor. But this age of polycrisis is also a moment of poly-opportunity, fueled by artificial intelligence, machine learning, quantum computing, and other modern technologies that are changing the world faster than people believe is possible.

Now, you are uniquely equipped to turn science fiction into science reality.

With the right mindsets, “Mission Impossible” can become “Mission Improbable” – as you overcome obstacles and seemingly long odds by imagining and innovating your way to novel solutions.

So: How do you go about that? How do you become the agents the world needs you to be?

You already have a head start, quite a significant one. You graduate today from MIT, and that says volumes about your knowledge, talent, vision, passion, and perseverance – all essential attributes of the elite 21st century agent. Oh, and I forgot to mention our relaxed uncompetitive nature, outstanding social skills, and the overall coolness that characterizes us MIT grads.

More seriously, you are trained in science, mathematics, engineering, and technology – fields that, when properly harnessed and supported, can be deployed against almost any seemingly impossible challenge.

You may not realize it yet, but your MIT education has given you a superpower – like X-ray vision – that lets you see through the illusion of impossibility and surface the blueprints for solutions.

And as of today, you even have a secret decoder ring, better known as the Brass Rat!

MIT’s history underscores these special powers. The telephone, digital circuits, radar, email, Internet, the Human Genome Project, controlled drug delivery, magnetic confinement fusion energy, artificial intelligence and all it is enabling – these and many more breakthroughs emerged from the work of extraordinary change agents tied to MIT.

Now let me ask you a question: Aside from MIT, what do such agents have in common? What equips them to accomplish seemingly impossible missions?

I’d argue that they do three things that make big leaps possible. They imagine, they innovate, and they immigrate.

And now, it’s your turn.

Start by unleashing your imagination.

People often see imagination as the exclusive province of the arts: of movie making, literature, painting.

I think that’s nonsense. Imagination, to my mind, is the foundational building block of breakthrough science.

I am not making an argument against reason. Reason has a role to play, but in accomplishing impossible missions, it’s the servant, not the master. You can’t expect reasoning to do the work of imagination. At its best, scientific research is a profoundly creative endeavor.

You have mastered proofs, and problem sets, and design projects, but in the words of mathematician and author Lewis Carroll: “Imagination is the only weapon in the war with reality.”

To the great Irish writer George Bernard Shaw, its role is even more fundamental. As he put it:

“Imagination is the beginning of creation. You imagine what you desire, you will what you imagine and at last you create what you will.”

It is also your turn to innovate. Think of innovation as imagination in action. Or, perhaps, mens et manus, or “mind and hand,” but I hear that line is taken.

MIT did not prepare you to shy away from the unknown, quite the contrary. You are now prepared to leap for the stars, sometimes quite literally — just ask the more than 40 NASA astronauts with MIT degrees.

Leaps often involve unreasonable or even seemingly crazy ideas. Ordinary innovations are often judged by how reasonable the idea is as an extension of what already exists, and how reasonable the person proposing it is.

But ask yourself: Why do we expect extraordinary results from reasonable people doing reasonable things?

As you’ve probably guessed by now, I am utterly unreasonable, and an eternal optimist. As a lifelong entrepreneur and innovator, I have to be.

But I’ve always practiced a special kind of optimism – I call it paranoid optimism. This means toggling back and forth between extreme optimism and deep-seated doubt.

The kind of paranoid optimism needed to make scientific or technological leaps often starts with an act of faith. By that, I mean belief without facts — the very definition of faith.

I know faith is generally associated with religion. But interestingly, in my experience, pioneering science also starts with faith. You take leaps of faith and then you do experiments.

On rare occasions, the experiments work, converting your leap of faith into scientific reality.

What a thrill when that happens!

On your innovation journey, beyond optimism and faith, you will also need the courage of your convictions. Make no mistake, you leave MIT as special agents in demand. As you consider your many options, I urge you to think hard about what legacy you want to leave — and to do this periodically throughout your life.

Not every mission you are qualified for is a mission worth accepting. You are far more than a technologist – you are a moral actor. The choice to maximize solely for profits and power will in the end leave you hollow.

To forget this is to fail the world — and ultimately to fail yourself.

I know many of you here – and some in the Class of 2024 not with us here today — are deeply troubled by the conflicts and tragedies we are witnessing. As an Armenian, descended from genocide survivors, and co-founder of the Aurora Humanitarian Initiative, I feel deeply the wounds of these conflicts.

I wish I had answers for all of us, but of course, I don’t.

But I do know this: having conviction should not be confused with having all the answers. Over my many years engaged in entrepreneurship and humanitarian philanthropy, I have learned that there is enormous benefit in questioning what you think you know, listening to people who think differently, and seeking common ground.

As you grapple with today’s hard choices — and the many that lie ahead — rely again on your imagination. Imagine the world you want to create and work backwards from there. Be open to the many paths that could carry you towards this goal and let the journey inform which ones will succeed.

I’ve urged you to imagine, and to innovate. The last thing I want to leave you with is the need to immigrate.

I’ll say more about what I mean by “immigrate” in a second, but first I want to give a shout-out to others who, like me, have left their homelands.

For those of you who have emigrated here from far away, or whose parents did, or whose grandparents did, please stand.

I applaud you.

It may often feel like a disadvantage, but you will soon learn it is quite the opposite.

When I first arrived at MIT, I worried I did not belong here: I spoke with an accent, my pastime wasn’t hockey or lacrosse, but Armenian folk dance.

Then one afternoon, late in my first year here, I was walking down the infinite corridor when a poster caught my eye. Staring back from the poster was a Native American chief in full headdress, eyes defiant, finger pointed, seemingly right at me. The poster read: “Who Are You Calling Immigrant, Pilgrim??”

I can’t tell you what an impact that had on me. Aside from Native Americans, we all, at some point, come from somewhere else. It helped me realize I belonged here — at MIT, in the United States. And graduates, families, YOU. DO. TOO.

But here’s the really interesting thing I’ve learned over the years: You don’t need to be from elsewhere to immigrate.

If the immigrant experience can be described as leaving familiar circumstances and being dropped into unknown territory, I would argue that every one of you also arrived at MIT as an immigrant, no matter where you grew up.

And as MIT immigrants, you are all at an advantage when it comes to impossible missions. You’ve left your comfort zone, you’ve entered unchartered territory, you’ve foregone the safety of the familiar. Yet, you persist and survive. You figure out how to accomplish your mission.

Like elite agents, immigrants are the ultimate innovators, equipped to navigate obstacles, to never say never. In fact, I often describe innovation as intellectual immigration. Just like those of us who emigrate from other countries, innovators pioneer new environments seeking a better future — not just for themselves but also for the larger world. So, whether you grew up in Cambodia, or in California, or right here in Cambridge, you can immigrate – and you need to keep immigrating. You need to leave your comfort zone, to think in new ways, to acclimate to the unfamiliar and embrace uncertainty.

If you imagine, innovate, and immigrate, you are destined to a life of uncertainty. Being surrounded by uncertainty can be unnerving, but it’s where you need to be. This is where the treasure lies. It’s Ground Zero for breakthroughs.

Don’t conflate uncertainty and risk — or think of it as extreme risk. Uncertainty isn’t high risk; it’s unknown risk. It is, in essence, opportunity.

I began with a TV show; I’ll end with a movie — the most recent Mission Impossible film released just last summer.

The film is a daunting reminder of all that your generation is up against: complicated geopolitics, climate threats and technological pressures, and AI tools that will both simplify and complicate our world.

But graduates, as I look at all of you, I see a large team of agents who are entirely capable of completing your missions. I see agents for good, agents for change.

MIT has prepared you to tackle impossible missions.

To harness the future and bend it toward the light.

My wish for you, my fervent hope, is that you not only choose to accept impossible missions, you embrace them. Welcome long odds. Embrace uncertainty, and lead with imagination.

Approach the unknown with the courage, the confidence, and the curiosity of an immigrant. With paranoia and optimism.

And always remember the strength of working in teams. Show the world why Mission-Impossible-Team inevitably shorthands to M – I – T.

Graduates, set forth on your impossible missions. Accept them. Embrace them. The world needs you, and it’s your turn to star in the action-adventure called your life.

Thank you.

[unimportantweirdo]

dolly parton vaccine superiority

[iero]

Have any of you guys had the second dose of the Moderna vaccine specifically yet and if any of you have, did you get any side effects afterwards?

[appalachiananarchist]

1. Vaccine data on preventing disease

I will start this post by summarizing (hopefully as simply as I can) a handful of studies pertaining to how well the vaccines work at preventing disease. I will start by looking at some of the early vaccine studies for the mRNA vaccines (as these are the ones I have researched most heavily). These are older studies done back before vaccine distribution really got big. In fact, I remember doing a journal club meeting on one of these articles sometime late last fall.

The first is one of the Pfizer studies. This one excluded people with compromised immunity which I understand, but angered me greatly when it came out (as a person with compromised immunity). Note that it was designed and funded by Pfizer, though when you look at the protocol and stats it appears well-designed. Like other studies discussed here, infection with COVID-19 used the FDA definition which is a positive test with at least one symptom (which can be basically anything). However, in summary, they found that a 2-dose regimen offered 95% protection against COVID-19 infection per the above definition. (SOURCE)

The second study (on Moderna) was funded by the Biomedical Advanced Research and Development Authority and the National Institute of Allergy and Infectious Diseases, and the study protocol was designed by Moderna with their assistance. This study also used the FDA definition of COVID-19 as a positive test with a symptom and excluded the immune compromised. However, it found that a vaccination was 94.1% efficacious in preventing COVID-19 infection. (SOURCE)

Now that that part is out of the way I wanted to go over some more real-world data; that is, how are these vaccines actually functioning out there? Are they working on a population level like these studies suggest they ought to? Well...

The Morbidity and Mortality Weekly Report from April through July of 2021 shows that vaccination reduces chances of catching COVID 5 fold. This report was important in examining how the vaccines are responding since the delta variant of COVID-19 has started to surge. (SOURCE)

A study out of California found in July of 2021 that COVID-19 infection rates in unvaccinated people are ~5X higher than in vaccinated people. (SOURCE) They do raise the concerns that more studies are needed on how long immunity lasts and whether it will wane. 

Another study examined COVID-19 vaccination effectiveness among health care workers, a group that is heavily exposed to COVID-19. They looked at whether the vaccines would prevent disease (in their study, defined as a positive test with at least one symptom). They specifically looked at the mRNA vaccines (Pfizer, Moderna). The study found "a single dose...to be 82% effective against symptomatic COVID-19 and 2 doses to be 94% effective." (SOURCE)

And before you say "but those were only symptomatic cases!" here is another study also looking at health care workers. This study spanning  December 2020-March 2021 basically tested all of their enrollees for 13 weeks and found that those who received 1 vaccine dose had 80% lower chances of getting COVID, while those with 2 doses had a 90% lower chance of getting COVID. This testing was done regardless of symptom burden. (SOURCE)

There is ongoing data collection on how long immunity lasts with some new reports (warning - following study is not yet peer reviewed) suggests that vaccine efficacy may drop to ~85% after 6 months in preventing disease, but efficacy in preventing severe disease remains very high, at 97%. Still, though, 85% is pretty good. (SOURCE)

So here are just a TEENY TINY number of the many studies coming out regarding the vaccines. I could sit here and list so many more, but then this post would be way too bloated and repetitive because they all say the same thing: the vaccine works. This conclusion is both consistent and reproducible, which when talking about scientific studies, means there is some good research backing it up. And before anyone says anything--YES, you can still catch COVID after getting a vaccine. Nothing works 100% of the time. Just because my car has an air bag and I use seat belts doesn't mean I won't get injured if I crash my car. But based on the available data, it works well in preventing infection in a lot of people, and furthermore, there is one other MAJOR benefit to the vaccine which I will discuss below.

2. Vaccine data on preventing severe disease:

Probably the most important realization that has come out of the past few months is our understanding of how robustly these vaccines effect disease course and severity. I am from eastern KY so one of the big hospital systems in my area is Appalachian Regional Health, which spans 13 facilities. According to their latest stats, they have 213 patients hospitalized with COVID-19. Of those, 16 are vaccinated. That means a little over 92% of the COVID patients there sick enough to need hospitalized are unvaccinated. For further reference, another major hospital in the region, Pikeville Medical, today reported that 70 of their 88 hospitalized COVID patients (~80%) are unvaccinated, and 20 their 24 (83%)��ICU COVID-19 patients are unvaccinated. Another regional hospital, Kings Daughters, had recently reported that 86.5% of those hospitalized with COVID are unvaccinated and 100% of COVID patients in their ICU are unvaccinated. So before I even get to national statistics, you can look at these numbers as already see a trend, and I would hope you can see that these numbers are way too high and too consistent to be coincidence. For sources on these numbers you can visit the ARH, PMC, & KDMC websites or facebook pages where they post their stats (HERE, HERE, and HERE)

Now to post a few studies backing this up:

A recent CDC Morbidity and Mortality Weekly Report (we talked about this one earlier) shows that vaccination reduces chances of hospitalization due to COVID-19 by ten fold. (SOURCE) The same report shows that vaccination reduces the risk of death due to COVID-19 by ten fold, as well!

Another recent study that incorporated delta variant data into their research has found that "unvaccinated adults aged ≥18 years are 17 times more likely to be hospitalized compared with vaccinated adults." (SOURCE).

Another study coming out of California, also post-delta surge, showed similar results, with hospitalization rates ~29X higher in unvaccinated people. (SOURCE)

Another study looked at how the vaccine protects adults over age 65, which is going to be a more vulnerable group. It found that adults >65 who received 1 dose of a COVID vaccine saw a 64% reduction in hospitalization if they contracted disease, and those with 2 doses saw a 94% reduction in hospitalization with disease. (SOURCE)

To me, studies like these are really important. What we are seeing over and over again right now is that our health care system is being absolutely flooded by unvaccinated COVID patients who need to be hospitalized. This is stressing the health system in ways it was not built to endure. We do not have enough equipment or staff to manage the volume of patients we are seeing. 

Sadly, this does not just affect COVID patients. When a bunch of unvaccinated people get sick and take up ICU beds, that means anyone who gets sick with non-COVID problems, like strokes and heart attacks, also suffer when there aren't beds left for them. For example, your grandmother who developed a bad bacterial pneumonia and is in respiratory distress may die because an unvaccinated COVID-19 patient got there first and took the last vent in the hospital, and there aren’t any ICU beds to transfer her to nearby because the wait lists are all so long because all the ICUs are also filled with unvaccinated COVID patients. I'd argue this is the biggest problem we are facing right now regarding the pandemic even if this problem is invisible to people who don't work in healthcare. Please believe me when I say this: we are drowning, and we are drowning because of unvaccinated COVID patients who are getting severely ill. This is completely unnecessary and avoidable when we are seeing over and over again that vaccination does wonders to prevent you from getting sick enough to need the hospital at all.

Don’t believe me still? I want each of you reading this to visit the webpage for some of your local hospitals. Most of them are posting daily or weekly COVID admission and death statistics. Just take a look at them. Take a look at who is getting admitted and who is dying.

3. Vaccine safety:

Any vaccine, medication, herbal supplement, or what have you that goes into your body carries the risk of an adverse side effect. As a result each of us has to ask ourselves, do the potential benefits outweigh the potential risks? To answer that we need to better understand the risks associated with COVID-19 vaccination, and that means turning back to the data we have available. 

According to NYT Vaccine Tracker, there have been 5.73 billion vaccine doses administered worldwide since its release. This generates an abundance of data for us to work with--more than we have for most medications you take every day--in regards to understanding safety profiles of these immunizations. Given that impressive number, we are by no means seeing widespread death or disability popping up due to the vaccine, but let's get more specific. We have seen a couple common possible adverse effects:

Flu-like symptoms: Most common by far is going to be flu-like symptoms or redness/pain at the injection site. This is actually a good side effect because it means that the vaccine is doing what it is meant to do. I won't talk much more about this one because I doubt flu-like symptoms are the reason people are scared of the vaccine. But for most of you, if you have any side effects at all, this will be as bad as it gets. You are more likely to have these symptoms after dose #2.

Anaphylaxis: Anaphylaxis can occur in anyone when you encounter a substance you have a try allergy to. This is going to be a rare side effect (2 to 5 people per million, or 0.00025%), but is also why you are asked to wait 15-30 minutes to be monitored after receiving your vaccine. That way if you show any signs of distress you can be given immediate treatment. Any time you get a vaccine or start a new medicine a severe allergy is a possible reaction, but if you already KNOW that you are highly allergic to something in the vaccine, you should not receive it.

TTP: This is a disorder that causes abnormal clotting or bleeding. It seems to be associated exclusively with the J&J or AstraZeneca adenoviral-vector vaccines based on current data trends. While rare, this is going to be the most serious adverse effect from the immunization. Data suggest the highest risk is for women under 50, but it is still remarkably rare with only 45 confirmed cases of TTP after over 14 million vaccine doses given. This is an incredibly, incredibly low incidence. Of note, however, patients with the actual COVID-19 virus have a SIGNIFICANTLY increased risk of clotting, especially in severe disease. This increased risk may be due to the production of auto-antibodies in response to COVID-19 infection. Summary: your risk of a blood clot is much higher with the actual virus than the vaccine.

Myocarditis/Pericarditis: These are conditions involving inflammation around the heart tissues or heart muscle. There does appear to be an increased rate of myo/pericarditis after vaccination. This is more common in teenaged males who received an mRNA vaccine (such as Moderna or Pfizer). This is also very rare. According to VAERS, 1404 cases of possible myo/pericarditis were reported after vaccination through September of 2021, though only 817 were able to be confirmed. A CDC report from June 2021 estimated about 60 cases of myo/pericarditis may develop per 1 million vaccine series completed (if you are male aged 12-17; otherwise the rate is lower). However, that same report also estimated the prevention of 71 ICU admissions, 2 death, and 215 hospitalizations among that same group per million vaccines given. Again it is a risk-benefit discussion, but here the numbers definitely point to a benefit overall. Vaccine-induced myocarditis and/or pericarditis are generally one-time events with an excellent prognosis, so rarely represent a threat to life. As the authors of the study linked above stated, "The absolute incidence was extremely low, cases were mild, and all patients recovered. Fear of myocarditis or pericarditis should not influence COVID-19 vaccine decisions."

Guillain-Barré Syndrome: This is a disorder of the nervous system that can cause temporary weakness and paralysis. It is commonly seen after immunizations or infections with various pathogens. It has been associated with adenovirus-vector vaccines (J&J, AstraZeneca) at a very low rate (about 0.0008%) with J&J reporting ~100 cases per 12.2 million doses per VAERS data, and 227 cases out of 51.4 million doses given per EU/EEA to the EMA again through June 2021. People with a history of Guillan-barre are more likely to get it again, so your risk is probably slightly higher if you have had issues with this before, so people with this history may want to opt for an mRNA vaccine which has not been associated with this. 

4. Addressing Common Concerns

If the vaccine works, why do you feel unsafe if I don't get it? A vaccinated person is more protected from you than if they were not vaccinated, but no vaccine (or medical treatment in general) works 100% of the time, so there is always a risk of spreading disease no matter what. This is true for every single vaccine in history so COVID shots aren't special in this way. The data supports indisputibly that the vaccine reduces the RISK of getting COVID, but does not protect against it perfectly, so people should still use common sense. Also, vaccine works much, much better when everyone gets them, which is why vaccinated people enourage others to get the shot too. Think about it. Most of the studies I linked said the vaccines were in the range of 90-95% effective at preventing disease. If everyone in the room is vaccinated, the chances any of them (with their 90-95% protection) are infected and spreading COVID is going to be lower than a room of unvaccinated people, who have no protection against disease. Think now of yourself as a vaccinated bystander inside each of those rooms. In room 1, there is a low rate of COVID-19 being spread around, so your vaccine-induced immunity is now bolstered by the fact that there is also low spread in the community, making your overall chances of getting sick extremely low. In room 2 there is likely moderate to high spread of COVID-19 virus, meaning that even if you are vaccinated, because your vaccine can never be 100% effective, you sadly still have a chance of getting sick (even if it is lower than it would be if you were not vaccinated). Does that make sense?

If vaccines work, why do I have to wear a mask? Same reason as above. We can get into masks later, but point is, both offer protection against the spread of COVID-19, but neither is 100% surefire perfect immunity. Human bodies just don't work that way, sadly. By using both, you increase your chances of preventing catching or spreading disease more than if you did either one in isolation. Bringing back the car example, a seat belt is good, an air bag is also good, but I'd definitely prefer to get a car that has both a seat belt AND an air bag.

Why is the vaccine not approved for kids? Lacking data on safety and efficacy, as young children were excluded from many of the trials that looked at these vaccines. 

We don't have long term safety data. It is unprecedented for an immunization to cause new side effects years later. These shots work by activating your immune system. Any problems they are going to cause will occur surrounding that period of immune activation (meaning, at most a few weeks after you get it). That is why this vaccines typically have any side effects show up within days to weeks of administration. The idea that novel side effects will pop up YEARS later is unlikely. Now, a vaccination may have cause side effect that has long-lasting health implications, such as developing TTP and having a stroke from it, but my point is that will start within weeks of vaccination, not randomly 5 years later after the vaccine has long since left your system. As a result, any side effects from the vaccine are things we will already be seeing right now. The virus, though...   I can tell you that scar tissue in lungs doesn't magically vanish, and brain damage from hypoxia doesn't vanish. I can tell you that those who develop a generalized COVID inflammatory response are dealing with symptoms months post-infection. I can tell you that the virus itself is causing irreversible health problems and disability, and we KNOW that right now without waiting another 5 years. And we know that being unvaccinated increases your risk of getting sick enough to have these permanent disabilities. We also don't have time to wait 5-10 years on more data to deal with this problem. Action has to be taken now, or a lot of people won't be alive in 5 years to talk about the long term effects. I wish none of this had ever happened, but it did, and we have to do something or it won't get any better. This is a global pandemic; we have to cooperate with each other to eradicate it.

Vaccines should not be mandated by the state or companies. I don't really disagree. I do not think authority figures should be able to tell any person that they have to put any substance into their body against their will or else face starvation or homelessness, which is a real threat if people get fired over their vaccine status. HOWEVER neither your nor my beliefs on this topic change the fact that the vaccine works and is VITAL to keeping our health system from collapsing, and you really should be choosing to get it on your own based on the available data regardless of what your boss is saying. Please don't refuse to get the vaccine just to "send a message" or take a stand against your boss or whoever, because I promise you they will fire you without a second thought, and the only person you are sending a message to is that little grandma we talked about earlier who needs intubated but can't find a free vent or ICU bed, so dies in the emergency room while unvaccinated people take up all the space in the hospital.

5. In Summary

There are risks associated with COVID-19 vaccination, as with any vaccine or medicine, but they are remarkably, remarkably low. The potential benefits of vaccination are significant, with a decreased risk of infection, hospitalization, and severe disease among those who are vaccinated. This benefit extends to the community as well, in that it means you are less likely to catch (and therefore spread) COVID-19, increase the rate of herd immunity in your area which protects everyone (especially the medically vulnerable), and reduces preventable, unnecessary COVID-19 admissions that are weighing down the health system and clogging up hospital beds. If you look at this purely from a risk-benefit standpoint there is no mathematical reason not to favor getting the vaccine, and I strongly urge everyone who can safely do so to schedule it.

I suppose my take-away statement is this: I am a physician. If you are willing to trust my advice when you show up to the hospital in respiratory distress, trust my advice now in trying to prevent you from getting to that point. 

Please.

[madamspeaker]

Boosted! Found a lovely pharmacy in Bloomsbury that had a walk-in clinic open, and no queue. So I have now joined the Moderna family. I’ll let you all know how I get on. My main vaccine was AstraZeneca, and the first dose of that left me flu-ish for around 16 hours (after no effects for the first 10 hours). The second dose of AstraZeneca had no side effects at all. I’ve been telling everyone at work that I got the Dolly jab today. So far, and it’s about a hour on since my shot, I feel okay, although my arm does feel a tiny bit odd. To be expected though.

[canary3d-obsessed]

I got my first dose of the Moderna vaccine today! And I only had to drive 6 hours round trip to get it! I qualify to get it now in my state (b/c asthmatic) but I live in the most populous metro area in the region, so doses and appointments are scarce. But I’m blessed with a car, so I went downstate where the population is sparser. 

[purpleplantdance]

May 1st, 2021

From left to right:

Echeveria White Zaragosa

Echeveria Snow Bunny

Echeveria Laui

Echeveria Suryeon

Currently sitting in my prop box because I got my first dose of Moderna today and holy crap I am dead.

[tj-crochets]

Warning: talking about how the vaccine is interacting with my health issues. I will tag all these posts “TJ talks about getting vaccinated” in case you want to blacklist them Hey, to all my POTS/MCAS/whatever the heck is wrong with my adrenals friends out there: So far, it’s been four hours since I got my first dose of the Moderna vaccine. I was totally fine, only a mild ache in my arm, until I stood up from relaxing on the couch and watching Captain Marvel to go to the bathroom. I got super dizzy and nauseous and my blood pressure dropped pretty sharply. It got better as soon as I sat down again, so I’m pretty sure it’s just a bad POTS flareup and not an allergic reaction, but my hands are still shaky. So, like, if you have the blend of POTS/MCAS/adrenal issues, maybe keep an eye on your blood pressure and be sure to stand up extra slowly after getting your vaccine? Keep your salt pills nearby if you take them? I begin to suspect that when they warned the vaccine side effects could include dizziness, nausea, and tiredness what they meant was low blood pressure, which is normally not a big deal but the POTS makes me like extra susceptible to. I’m okay! Still very glad I got vaccinated, still feeling super lucky I was able to, just gonna take it easy and maybe try to rig a way to sit at my desk with my feet up tomorrow. I wanted to share in case it helps y’all  Also to explain why I’m not posting any new stuffed animals today and probably not tomorrow either. 

[simonalkenmayer]

Happy thing: Got my first vaccine dose today! Moderna. I'll keep you posted how things go!

Congratulations! It makes me so happy to keep seeing people with those stickers and returning to a semblance of normalcy. Very very happy. I wish we’d had vaccines like this back during any of the plagues I’ve seen. Such progress!

[allisondraste]

I was able to get my first dose of the COVID-19 vaccine today. If you have any questions or concerns about side effects, I plan on keeping a record of my experience.

It’s about an hour since I got the Moderna shot, and my arm is sore and I feel a bit tired, but nothing major.

[bobcatmoran]

So, a few weeks ago (a couple weeks? a month? what is time, anyway), my boss said that all of us in the office had the opportunity to get on a list of “law enforcement” that’d be eligible to get unused doses of the vaccine that’d otherwise go bad if they didn’t get into someone’s arm quickly. I said, “Heck yeah,” and signed up.

Cut to today, while I was taking a walk after work, when I suddenly got a phone call from my boss. Could I get to Location XYZ within an hour? I could. Why? Because they had some doses of the vaccine.

So I booked it back home, grabbed my work ID, and drove down to a church, where I got my first dose of the Moderna vaccine!

It was surprisingly crowded while waiting for the vaccine. I talked a bit with one of the gals running this, and they’d been out going to some of the last few long-term care facilities locally — very small places that had only a few people, and vaccine skepticism was unfortunately high since they ended the day with 40 extra doses. So there were 40 of us, law enforcement of varying degrees (I mean, my office enforces laws around importing mangos and bringing wheat rusts into the country, with enforcement powers that mostly consist of saying “please” and maybe sending a strongly worded letter), all crammed into this church lobby.

The crowd thinned out though as people got their vaccines and finished up with their 15-minute waiting periods, and me and two of my coworkers (including one who was juuuust under the current age limit and has some comorbidities) got our vaccines!

It was a very tiny needle with a very quick jab, and quite possibly the most painless shot I’ve ever gotten. Second dose is already scheduled, and I super duper encourage anyone who gets the opportunity to get themselves vaccinated — please feel free to ask me any questions about the experience if you want to know more!

[asokatanos]

I got the first dose of the covid vaccine yesterday (Jan 5th 2021)!! Sharing 2 days of my experiences so that when access has been expanded and doses are available more widely you’ll have my story regarding safety and side effects.

Some facts: I got it early because I’m a medical student seeing patients (lately a lot of covid pts!). I am otherwise mostly healthy without any serious chronic or autoimmune conditions. The reason healthcare workers are being prioritized is not because we’re going to get more sick, but because if we DO catch it, we might accidentally spread it to patients who might themselves become very ill. Our jobs mean we are exposed to and exposing many many people every day. No WFH here!

Once you register you get a little card with the vaccine company (in the US rn moderna or pfizer only) and today’s date and a date 28 days later which is the date of your next and (hopefully) final dose/appointment.

I got the first dose of the Moderna vaccine after answering some screening questions about history of severe allergic reactions, recent covid (+) test or quarantine, a temperature check, etc. The shot itself was delivered with a small gauge syringe 💉. It actually hurt WAY LESS than the flu shot I got several months ago!! I’m a big baby when it comes to needles (ironic! I know) but this was NOT BAD AT ALL. Genuinely barely felt it. 1/10 pain scale. The 1 is just because I knew the needle was going in

They had me sit for 15 min afterwards to make sure I didn’t pass out or suddenly get an allergic reaction. I was just fine! Left the hospital and got totally lost on my way home thanks to my goddamn gps which for some reason took me ACROSS STATE LINES I am going to kill google-

Two hours later my arm felt mostly normal. No pain! 0/10 pain scale. The area felt like it might be a little warm and maybe ever so slightly numb, but this might just be because I was mentally focusing on it very intently since receiving the shot.

Pain began maybe four hours after the shot. Gradual soreness that went from a 4/10 to maybe a 6/10 by bedtime (11 hours later). It’s not sharp or stinging, it feels like the same dull sore sensation one gets after a flu shot. Maybe slightly worse, like something between a flu and tetanus shot. I will survive it even though my mom accidentally bumped the spot no less than three times

Around 11pm or so I started getting a headache. This might have been secondary to personal stress or maybe the several hours I spent watching tv or the fact that I’ve been prone to bad headaches for several years now. But it’s also a known vaccine side effect. I took two ibuprofens at around 10:45pm because of the arm soreness

Okay so I didn’t sleep much over night. Part of it is stress but also my arm hurt. I’m used to sleeping on my left side buuut the shot was in my left arm :/

And in the morning about 22 hours after I got the vaccine the arm soreness is worse, maybe 7-8/10. I took another two ibuprofen so we’ll see how it goes. No other side effects though just the sore arm.

okay so it’s now about 6pm and fascists are taking over my country’s capitol building so i haven’t been focusing on my arm so much. the good news is that it hurts less now! still hurts to move it in abduction (which is medical for out away from the body like an airplane pose) but it’s way less severe. a steady 4-5/10

Everything is unhinged now so I’m just scheduling this post for Jan 7th and hoping there are no further historical events in the next 24 hours.

Jan 7th update is that it doesn’t hurt anymore!!

[lestatslestits]

I got my first dose of the Moderna COVID vaccine today! If anyone has any questions feel free to ask!

[moghedien]

In case anyone is interested/concerned about the vaccine, here are my side effects the first 24 hours after getting my first dose of the Moderna:

- most of yesterday I just felt tired and like I got punched in the arm. I just took a nap basically, woke up to shower and stuff, and then went back to bed. That’s kinda normal for me based on how my immune system reacts when I have, say, a cold or sinus infection. I tend to just sleep for a long time.

- the worst thing was that I kept turning on my side that I got the shot on and waking myself up because it’d hurt. The arm pain didn’t hurt enough to discourage me from using my arm and it was mostly just when I’d move it or touch it.

- today, my arm still hurts but it just feels kinda bruised and it’s better than it was yesterday. If I’m resting it, I don’t feel anything.

- I kinda have a scratchy throat but it isn’t bad and honestly could very likely be my allergies. At worst, it feels like I’m getting a cold.

-I haven’t checked my temp but I never felt any chills or fever symptoms

Overall, this is pretty much exactly how I felt after getting my flu shot. The side effects are at worse annoying, and mostly unnoticeable unless I draw attention to them.

I’m mostly posting this in case anyone needs encouragement to get the vaccine. If it’s available to you, please get it! Unless you have been told by your doctor that you shouldn’t for some medical reason, please get it when it’s available to you! A day or two feeling like I have a mild cold is definitely better than the alternative

[kendrixtermina]

So, there has been a wee bit of a vaccine side effect.

It’s fairly common with the second dose, I suppose. Chills, feeling suddenly like everything is hotter even though the weather is the same as yesterday, general flu/cold type feeling in the body, loss of apetite, and rly pronounced fatigue to the point that going to the fridge to get water seemed exhausting... im not sure if my temperature was elevated but it wouldnt surprise me. 

The reason I’m even sitting and typing right now is probably cause I chugged that one paracetamol I had left in the fridge. Or maybe it’s finally passing, either way I used this moment of feeling slightly better to get some dinner into myself.

Good thing I had this cucumber salad prepared which I meant to take on the train today. As you migh expect, I cancelled my plans and spent most of today in bed so that my immune system could just do its thing.

It’s amazing how quickly it happened, truly from one day to the next, like getting a cold in fast forward. I guess the vaccine must be really efficient at provoking an immune reaction.

I got the moderna though so all this is from just 1 protein, I don’t even want to imagine what actual Corona is like... Well. Good thing im fully vaxxed now, I suppose. 

Oddly enough the arm itself did not hurt as much as the first time. 

. 

[capnsaltsquid]

Got my first dose of the Moderna vax today and now I have built in 5G that lets me stream 4K direct to my brain.  No more monitors for me!

LOLJK, my arm’s just kinda sore.  Not that direct video-to-mind streaming wouldn’t be cool, but I don’t believe for second that google wouldn’t use it to send annoying ads directly to my optic nerve.