#canine medicine

[er-cryptid]

[academiavet]

Sobre o uso da budesonida em cães e gatos com Doença Inflamatória Intestinal...

Em geral a budesonida tem sido relatada na literatura como um corticoide de ação mais local, com pouca absorção sistêmica e raros sinais clínicos de hipercortisolismo (Síndrome de Cushing), quando comparada à prednisona, fármaco mais usado rotineiramente no controle da Doença Inflamatória Intestinal (DII).

Um relato de caso publicado na Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP mostra o uso da budesonida para controle da DII em um cão como alternativa à prednisona, porém aparentemente sem expressar tantos efeitos locais quanto previsto na literatura.

Vale a pena ressaltar que nesse caso o paciente já estava em estado muito avançado de DII e sofrendo com efeitos colaterais da prednisona, o que possivelmente fez com que a corticoterapia com a budesonida não fosse tão efetiva assim.

Entretanto, podemos ver uma conclusão interessante sobre o uso dessa droga na DII:

De acordo com o que foi visto no caso relatado, é mais provável que a budesonida deva ser utilizada quando há controle prévio da DII em cães, não como opção única no tratamento da doença e, sim, com cautela quanto aos seus reduzidos efeitos adversos em comparação aos corticosteroides comumente utilizados na rotina (ex.: prednisolona).

Leia o seguinte relato descrito na íntegra: https://www.revistamvezcrmvsp.com.br/index.php/recmvz/article/view/302

Já em relação aos gatos com DII, a budesonida é indicada como corticoide de ação local quando a doença tem se manifestado de maneira mais leve e inicial na dose de 3,0 mg por gato, SID, PO, manipulado em cápsulas resistentes ao suco gástrico (ALLEN, 2010 apud DEUS, 2022). Caso não haja a resposta de melhora (diminuição das paredes das alças) pode-se trocar a budesonida pela prednisolona, sendo ambos os fármacos associados com uma nova dieta a base de rações hipoalergênicas que não induzem tanto a resposta antigênica (DEUS, 2022).

Referências:

Insucesso no controle da doença inflamatória intestinal com uso da budesonida – Relato de caso. Palacios Jr, R. J. G.; Aoki, G. G.; Tristão, A. P. P. A.; Adams, F. K.; Rondelli, M. C. H.; Tinucci-Costa, M. Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP, v. 10, n. 1, p. 63-63, 11.

ALLEN, H. S. Therapeutic approach to cats with chronic diarrhea. Consultations in feline internal medicine. 6th ed. St Louis: Saunders Elsevier, p. 240-247, 2010.

DEUS, Caroline de. RELATÓRIO DE ESTÁGIO CURRICULAR OBRIGATÓRIO EM CLÍNICA MÉDICA E CIRÚRGICA DE FELINOS. 20 dez. 2022.

[canisalbus]

✦ Mom ✦

[equinesandeducation]

Spent the morning on working up toxicology cases and had a short seminar about animal physiotherapy in the afternoon! They showed the work on both canine and equine patients, very cool!

[featherycrimes]

A quick chibi ref sheet for my OC, Henry since he had no proper outfit reference for ArtFight :]

You can find his profile here: https://artfight.net/character/4180010.henry

[mandana-the-service-pup]

Methotrexate Update

Doctor got back to me about my labs. My absolute monocytes are high but she isn’t concerned. She didn’t explain why (my best guess it’s bc my exercise has increased so drastically in such a short amount of time but idk) She says I can stay at the same dose and she doesn’t need another lab for three months. I have been doing GREAT on it. Hardly any negative side effects.

The stomach pain I’ve had every night for a year is gone.

My post-exercise chest pain that I’ve been going to cardiologist and ER for since Oct 2022 is completely gone (playing and shoveling snow 100% would have set that off)

TMI // My period has been freaking purple since Sept 2022 and I’ve been bleeding so much that the OBGYN thought I had a fibroid rupture. Well I just had my first period on Methotrexate and it’s all back to normal now and the amount was 1/3 what it has been which is a huge relief. It still hurt but I was able to eat and drink which I usually struggle with for the first few days. Maybe the pain will get better over time.

My gums don’t bleed any more when flossing. It just stopped as soon as I started methotrexate.

I’m able to eat and drink a lot more than I was which is great.

I have way more range of motion in my joints (which is making me have more problems with my hypermobility but whatev)

I still have muscle and joint pain but I honestly think most of it is bc I’ve been able to do so much more. I was taking 600 mg ibuprofen 2-3 times a day and my pain was still 7-7.5/10 and now I’m not taking any ibuprofen except maybe once every couple days and it’s a solid 6-6.5/10

Oh and I can take deeper breaths. Like I’m still having low oxygen show up on my oxymeter but for most of my life my ribs have felt like I’m wearing a corset and they can’t expand when I breath in and that has improved so much that I just walk around the house thinking “wow. I can take a breath. Wow” I’m not sure if this is due to my joints and ribs having more range of motion or if it’s connected to the hyperinflation of my lungs that showed up on the X-ray. Idk but it’s awesome and I’m making an appointment with pulmonologist again to double check lung stuff

The only con I’m currently having is the high absolute monocytes which my dr says is fine and I’ve been having really bad night sweats (actually I’m sweating a ton all the time) but I think my body is just like…recalibrating. Usually effects are really seen after a few months so I’m super excited for 2024!

Mandana’s Health Update

Surprise surprise the new vet doesn’t want to prescribe LDN/s

I get why. There are no studies on using LDN for pain in dogs (there are a few cancer studies in dogs which include LDN for pain relief and QOL but whatev) I humored her and tried to use Carprofen but Mandana doesn’t do well on pain meds and always gets an upset stomach after a couple days. This time was no different and she was miserable and vomiting so I took her off it. We discussed all of our options which I’ll list now for reference:

Decrease carprofen from 75mg twice a day to 75mg once a day // not gonna work bc the original dose wasn’t even very effective for managing her pain and I imagine if she’s already having problems with NSAIDs then taking even a small dose every day for years will hurt her.

Try a different NSAID called Meloxicam // we expect the same problem we have with carprofen

Try a different type of pain relief called Amantadine // Used along side NSAIDs (which we can’t do) so not very effective on its own and can have a side effect of urine retention which Mandana is prone to (she gets this as a “rare” side effect of both apoquel and Benadryl so I would rather not risk it, esp since Proin gave her high blood pressure and we had to discontinue it so there would be no back up if she got incontinence again)

Try the new type of pain relief that was just approved in the US called Librela // This is what we’re going to do next. She has an appointment for her first injection 1.5 weeks from now.

Consult with a Neurologist and get an MRI // After we get her back pain approved by our PetsBest insurance we will make an appointment for a neurologist consult and MRI. The two X-rays we have are 9 months apart and show a narrowing of the disc space between L4-5 but the general consensus is that it shouldn’t be causing as much pain as she is in so an MRI will give us a better idea of what’s going on and the Neurologist might have more treatment options for us.

We really want to wrap up some of these big health concerns for both of us before 🐾2025🐾👀 and we are already making a lot of progress so I’m super hopeful!

[imperialpetco]

Blogger: User Profile:  Imperial Pet Co.

Marvelled by natural and holistic vets around the world, Imperial Pet Co. leads the pet market with the most natural canine health supplements. Taking their cue from nature, Imperial Pet Co. is giving dogs and dog owners hope for a natural solution to canine health.

[traditionanddebts]

harrow’s teeth? bad i think. in what way? overbite? underbite? obvoiusly sharp canines, for the hashtag #aesthetic, but what else. gap tooth? gap tooth. that would be so adorable. she’d hate it so much. oh my gosh. can you imagine. yes

[impostorhottie]

Canine Histopathology

[reinmoriko]

Commissions for  stardustミ☆ (#287001), detective (#135892) & CheetahMeows S2 (#236884) on Lioden

The Bayleef belongs to stardustミ☆ (#287001) on Lioden

The Warrior Cat Custom belongs to detective (#135892) on Lioden

The Wolf OC belongs to CheetahMeows S2 (#236884) on Lioden

Credits for each character belong to their respective owners!!

Only commissioners may use this artwork!!

[umagarotasingela]

[iheartvmt]

Ugggghhhhh canine influenza outbreak in the state, so of course now all the brands of the vaccines are on backorder 🙄

[howgaytobequeer]

November 17th, 2023.

Right now the top suspects are either HPAI (highly pathogenic avian influenza) or covid. If at all possible, avoid taking your dog to dog parks and day care, especially if your dog is older or already has difficulty breathing.

[dogcancerfoundation]

What's the Endocannabinoid System?

Consider the phrase ��endocannabinoid.” The phrase “cannabinoid” is derived from the word “cannabis,” and “endo” refers to the fact that it is formed naturally within the body. As a result, “endocannabinoid” actually refers to cannabis-like compounds that exist naturally in our dogs (and our) bodies. Our dogs, us, our cats, and other mammals all have the same endocannabinoid system. The ECS itself…

[ataleoftwopitties]

LEPTOSPIROSIS IN DOGS

Leptospirosis is a zoonotic disease caused by the infection of bacteria belonging to the genus Leptospira. It is most commonly transmitted through mucous membrane contact or wound exposure to urine of infected mammals, or contaminated food, bedding, soil, or water. 

Leptospira like to live in warm, wet environments like damp soil/grass, mud, standing water, and lakes or ponds. Under ideal conditions, the bacteria can survive more than three months outside the body. Rodents and domesticated animals including raccoons, skunks, opossums, rats, cows, and pigs are but a few of the many known carriers. Because of the broad range of carrier species, any dog - even one that is briefly outdoors - may be vulnerable to the disease. 

Each year, more than a million cases of leptospirosis are reported worldwide, with an estimated 59,000 deaths. Leptospirosis continues to be prevalent in dogs, although symptoms may vary depending on the strain of Leptospira bacteria and the dog’s immune system. While some infected dogs may show little to no signs of illness and recover on their own, others may develop severe, life-threatening illness. Most common signs include:

Lethargy

Loss of appetite

Vomiting/diarrhea

Abdominal pain

Jaundice (yellowing of the skin or mucous membranes)

Dehydration

Increased thirst and urination

Weight loss

Stiffness or muscle pain

The disease may progress into acute kidney and/or liver failure. Some dogs may even develop lung disease and rapid, difficulty breathing, damage to the heart muscles, or bleeding disorders that may exhibit through blood-tinged vomit, feces, or urine, nose bleeds, or petechia (red spots or bruising on the gums and other light-skinned areas). Fluid may also build up in the body, causing swollen limbs or excess fluid in the chest or abdomen. 

Because leptospirosis may appear like many other illnesses, it is important to share information about your dog’s lifestyle and travel history that may highlight possible exposure to Leptospira bacteria. While there are various leptospirosis testing available, micro-agglutination tests (MAT) are the gold standard, and additional diagnostics including bloodwork, urinalysis, and ultrasound may also be recommended. 

Leptospirosis is generally treated with antibiotics and supportive care. Patients are often hospitalized to receive fluid therapy, IV medications, nutritional support, and sometimes oxygen therapy and/or plasma transfusions in more severe cases.

Fortunately, there are vaccines available that protect against this life-threatening disease. Vaccinating dogs for leptospirosis may help protect their owners from infection, too. Aside from that, other precautions should be made to reduce risk of exposure:

Avoid letting your dog swim or drink from lakes, rivers, ponds, or any slow-moving or stagnant waters, puddles, or public/shared water bowls

Keep your dog away from farm animals and rodents, including carcasses, and minimize free-roaming in rural or peri-urban areas

Protect your dog’s paws with booties if they have any open wounds or sores

WARNING: If your dog is diagnosed with, or suspected to have leptospirosis, it is important to note that any animals that are not treated completely may shed Leptospira bacteria in their urine for up to three months. Promptly clean and disinfect any urine or contaminated areas within the home, and wear gloves while doing so. Also be mindful in guiding your dog to urinate far away from any areas other people or animals may have access to.

SOURCES/FURTHER READING

“Leptospirosis in Animals.” CDC, U.S. Centers for Disease Control and Prevention, 29 Apr. 2024, www.cdc.gov/leptospirosis/pets/index.html. 

“Leptospirosis in Dogs.” AVMA Resources for Pet Owners, American Veterinary Medical Association, www.avma.org/resources-tools/pet-owners/petcare/leptospirosis. 

Lunn, Katharine F. “Leptospirosis in Animals - Overview.” Merck Veterinary Manual, Merck & Co., Inc., Feb. 2022, www.merckvetmanual.com/generalized-conditions/leptospirosis/leptospirosis-in-animals-overview. 

Sykes, Jane E., et al. “Updated ACVIM consensus statement on leptospirosis in dogs.” Journal of Veterinary Internal Medicine, vol. 37, no. 6, 20 Oct. 2023, pp. 1966–1982, https://doi.org/10.1111/jvim.16903. 

Sykes, Jane E., and Krystle L. Reagan. “Leptospirosis in Dogs: Diagnosis, Treatment, and Management .” Today’s Veterinary Practice, no. Sept/Oct 2019, 9 Aug. 2019, https://todaysveterinarypractice.com/infectious-disease/diagnosis-and-treatment-of-leptospirosis-in-dogs/. 

[gizmotemusic]

You know how the word "feline" refers to cats, and "canine" refers to dogs? There are a whole bunch more animal adjectives, and here are some of them:

equine -> horses

bovine -> cows

murine -> mice/rats

porcupine -> porcupines

wolverine -> wolves

marine -> marmosets

saline -> salmonella

cosine -> cosmonauts

citrine -> citrus

combine -> combs

famine -> your fam

bromine -> your bros

palpatine -> your pals

alpine -> alps

christine -> christ

asinine -> asses

machine -> the speed of sound

landmine -> explosions

migraine -> migrants

trampoline -> tramps

dopamine -> dopes

medicine -> the Medici family

praline -> prey

masculine -> mascara

feminine -> femurs

latrine -> latissimus dorsi

fettuccine -> fetuses

poutine -> sadness

turbine -> turbans

engine -> england

supine -> soup

valentine -> valence electrons

Follow for more nature facts!