#Improve Health Outcome

[dolivia]

Improve patient outcomes by using patient education and navigation strategies that work. Check out our blog on LinkedIn to see what is healthcare navigation and how can help you make better health decisions by improving your understanding.

[aeide-thea]

thinking abt how like. ~recovery~ sort of necessarily involves going against yr maladaptive instincts to some degree but also if yr bullying yrself into it out of, like, guilt or whatever (as opposed to some degree of actual positive hope) it doesn't really qualitatively feel any different than the dynamic that overrode yr autonomy and crushed yr spirit in the first place…

[bestautocare]

Healthiga – Your Gateway to Smarter Healthcare Solutions

Healthiga offers comprehensive, tech-driven healthcare services designed to simplify health management for patients and providers. Experience personalized care, innovative tools, and efficient solutions tailored to meet your healthcare needs. Transform your health journey with Healthiga.

[eepiebeepy]

if i was a chimpanzee (magically turned into one, alternate dimension, etc) i would teach them how to brush their teeth

[publicheath]

Upcoming Public Health Conferences: A Look into 2025

[girlwithrituals]

GLOW UP GUIDE FOR 2025⠀

READ: On average, it takes more than 2 months before a new behavior becomes automatic — 66 days to be exact. And considering that 2025 is precisely these many days away, why not start with our glow up plan already?

Physical Glow Up-

BODY

— 5-10K steps a day.

— 7-8 hours of sleep.

— workout everyday for 1 hr atleast- yoga/stretching/pilates/cardio. a workout may take one hour, but your mood will be boosted for the next 12 hours.

— posture training.

— sunlight exposure after waking up for at least 10 minutes.

NUTRITION

— 2-3 liters of water every day.

— limit your caffeine intake.

— avoid sugars as much as you can.

— high protein diet, pre and probiotics.

— more fruits and veggies (+ green smoothies if you like).

— no junk/processed food/trans fat.

— no eating after 8 pm.

SKINCARE

— be clear on your skin type (oily, dry, combination, sensitive).

— once you're clear, use these accordingly- cleanser, toner, targeted serum, eye cream, moisturizer, sunscreen (≥50 spf).

— keep your bedding clean as well.

— no picking of skin on your lips, cuticle etc.

— gua sha to help improve blood circulation and lessen toxins.

— cold therapy may take three to five minutes of being uncomfortable, but your energy levels will be boosted for the rest of the day.

— remove makeup before you go to bed.

BODY CARE

— shower every day.

— exfoliate 2x a week.

— use body lotion (shea butter/aloe vera gel/coconut oil).

HAIR CARE

— wash hair 2-3x a week

— oil your scalp 2x a week, at least 3 hours before shampoo.

— hair mask 1x per week.

— never brush wet hair.

— use silk pillow case.

HYGIENE

— brush your teeth 2x a day, clean tongue and the roof of the mouth daily.

— floss daily.

— cut your nails 1x a week, never remove the cuticles.

— glycolic acid under arm for odor and discoloration.

— never use soap on your coochie.

Mental Glow Up-

MINDSET

— set clear goals- define and breakdown your aspirations.

— start your mornings with positive affirmations.

— surround yourself with uplifting content and people.

— be shamelessly selfish to your career and mental health, remove anyone or anything that doesn't align with your priorities and wellbeing.

— boost your brain health by these 4 neuroscience tools:

difficult first: start your day with the most difficult task (cortisol and dopamine are high in the body meaning that your body/mind is primed to work).

rest your eyes: introduce a micro-pause after learning by resting/closing your eyes - will help retain information better.

tomorrow's worries: write tomorrow's to-do list before bed as it is proven to be effective in helping you fall asleep.

find time to play: engage in low-stake play. can be anything you find fun but where the outcome doesn't matter (induces neuroplasticity + reduces stress).

MIND

— meditation might take as low as ten minutes, but your focus will be improved for the rest of the day.

— no social media after waking up and at least an hour before bed.

— keep aside 1 hr of time to read daily! reading a new book may take five hours, but you will keep the knowledge forever.

— journaling, gratitude.

— digital detox once a week or for 12 hours.

— limit unnecessary screentime, unfollow or cut off people you don't want to see.

JOURNALING

— choose a regular time each day to journal, making it a part of your routine.

— find a quiet, comfortable place free from distractions. light a candle if you want.

— allow your thoughts to flow without censoring or editing.

— write about your feelings and emotions to understand them better. write about things you are thankful for to boost your mood. write about your short-term and long-term goals. identify what triggers certain emotions or reactions

— set a timer for 5-10 minutes and write continuously during that time.

— reflect on both positive experiences and challenges.

— make lists, journal your thoughts on these questions.

— journal at night to clear your mind before bedtime, because emotions and thoughts lose their power once we acknowledge them.

— a gratitude practice may take five minutes, but your mindset will be shifted for the rest of the day.

AFFIRMATIONS

— customise affirmations to your needs.

Personal Life-

WEEKLY TASKS

— initiate small changes: begin with small, manageable tasks such as making your bed or cleaning your room every sunday.

— celebrate your success: reward yourself when you achieve your goals or have a consistently productive week. consider treats like buying flowers for yourself or watching your favorite show.

DAILY WORK

— set achievable goals: establish realistic goals for the day, week, or month ahead.

— track your progress.

— organise your work space, declutter your shelves etc.

— embrace the power of lists: keep a list of tasks to be done and their deadlines. this way, you start each day with a clear plan. to make it visually appealing and motivating, consider using productivity apps like evernote, habit tracker, or notion.

PRODUCTIVITY TIPS

— wake up early.

— plan ahead everything, do scheduling. you can use:

google calendar / notion / tasks .

— if the task takes less than 2 minutes to finish, do it immediately.

— countdown rule, if you are procrastinating, count 1-2-3-4-5 and jump.

— start slow, don't rush and try to do everything at one time.

— follow a proper routine, use app locks based on screentime.

— pomodoro technique, 25 min work, and 5 min break.

— schedule longer break times as well e.g 30 min nap.

[ivygorgon]

An open letter to the U.S. Congress

FUND WIC NOW! Don’t leave women and children hungry!

1,038 so far! Help us get to 2,000 signers!

I am deeply concerned about the potential harm to nutritionally at-risk women with low incomes and their young children if Congress fails to provide the funding needed for WIC in the FY24 spending package. WIC is essential to the health and well-being of over 6.5 million women and young children, including roughly half of all infants born in the U.S. It provides families with wide-ranging benefits and services, including safer pregnancies, improved dietary outcomes, and the healthy growth and development of children. Congress previously recognized the profound benefits of WIC by making significant investments in the program during the COVID-19 pandemic, including increasing the monthly value of the fruit and vegetable benefits for women and children. This, along with innovative outreach and increased demand, has fueled the ability of WIC to reach the increasing numbers of those who are eligible. But without full funding for WIC, this progress will quickly unravel. Participants are at risk of losing these vital benefits if Congress does not include enough funding for WIC in the final FY 2024 funding bill. This will result in an interruption of services, and long waiting lists, leading to more moms, babies, and young children struggling against hunger, lacking adequate health care, and losing out on other vital WIC services. I strongly urge Congress to continue the long, historic, bipartisan support for WIC and to include full funding in the final FY24 appropriations bill to ensure access to WIC’s nutrition and health benefits and services. An investment in WIC is an investment in our nation’s future. Thanks.

▶ Created on January 8 by Jess Craven

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[leanonmehomecareinc]

Home care can contribute to a care recipient’s health and well-being in myriad ways, encompassing both physical and emotional aspects. If this is something you would like to explore further, Lean On Me Home Care, Inc. has you covered!

[shubhragoyal]

Explore the significance of endoscopy in empowering fertility for couples - a comprehensive guide. Learn how it can visualize your dreams.

Do Visit: https://www.drshubhragoyal.com/welcome/blogs/visualizing-dreams-the-role-of-endoscopy-in-empowering-fertility-for-couples

[peachtacular-home-health-care]

For vulnerable populations, including the elderly or the medically compromised, receiving compassionate care can go a long way toward fostering their health and wellness. Would you like to gain a better understanding as to why? Peachtacular Home Health Care, a premier provider of at home care, will be more than glad to lend you a hand.

[fatliberation]

I saw a comment on your blog that says 'the way you eat does not cause diabetes'...are you able to expand on that or provide a source I could read? I've been told by doctors that my pre-diabetes was due to weight gain because I get more hungry on my anti psychotics and I'd like to fact check what they've told me! Thank you so much!

Pre-diabetes was rejected as a diagnosis by the World Health Organization (although it is used by the US and UK) - the correct term for the condition is impaired glucose tolerance. Approximately 2% of people with "pre-diabetes" go on to develop diabetes per year. You heard that right - TWO PERCENT. Most diabetics actually skip the pre-diabetic phase.

There are currently no treatments for pre-diabetes besides intentional weight loss. (Hmm, that's convenient, right?) There has yet to be evidence that losing weight prevents progression from pre-diabetes to T2DM beyond a year. Interestingly, drug companies are trying to persuade the medical world to start treating patients earlier and earlier. They are using the term “pre-diabetes” to sell their drugs (including Wegovy, a weight-loss drug). Surgeons are using it to sell weight loss surgery. Everyone’s a winner, right? Not patients. Especially fat patients.

Check out these articles:

Prediabetes: The epidemic that never was, and shouldn’t be

The war on ‘prediabetes' could be a boon for pharma—but is it good medicine?

Also - I love what Dr. Asher Larmie @fatdoctorUK has to say about T2DM and insulin resistance, so here's one of their threads I pulled from Twitter:

1️⃣ You can't prevent insulin resistance. It's coded in your DNA. It may be impacted by your environment. Studies have shown it has nothing to do with your BMI.

2️⃣ The term "pre-diabetes" is a PR stunt. The correct term is impaired glucose tolerance (or impaired fasting glucose) which is sometimes referred to as intermittent hyperglycemia. It does not predict T2DM. It is best ignored and tested for every 3-5yrs.

3️⃣ there is no evidence that losing weight prevents diabetes. That's because you can't reverse insulin resistance. You can possibly postpone it by 2yrs? Furthermore there is evidence that those who are fat at the time of diagnosis fair much better than those who are thin.

4️⃣ Weight loss does not reverse diabetes in the VAST majority of people. Those that do reverse it are usually thinner with recent onset T2DM and a low A1c. Only a tiny minority can sustain that over 2yrs. Weight loss does not improve A1c levels beyond 2 yrs either.

5️⃣ Weight loss in T2DM does not improve macrovascular or microvascular health outcomes beyond 2 years. In fact, weight loss in diabetics is associated with increased mortality and morbidity (although it is not clear why). Weight cycling is known to impacts A1c levels.

6️⃣ Weight GAIN does NOT increase the risk of cardiovascular OR all causes mortality in diabetics. In fact, one might even go so far as to say that it's better to be fat and diabetic than to be thin and diabetic.

Dr. Larmie cites 18 peer reviewed journal articles (most from the last decade) that are included in their webinar on the subject, linked below.

[lovscb97]

tags: park sunghoon x fem!reader, established relationship, size kink, strength kink, bulge kink, d/s dynamics, dom!sunghoon x sub!reader, unprotected sex (plz don’t), breeding kink, creampie, dirty talk, degradation (slut, whore), praise kink?, nicknames (baby, princess, angel, hoonie, etc), slight fluff, lowkey pwp, reader is described to be shorter than hoon and is easy to pick up/throw around, reader is also very down bad for him (aren’t we all), etc

wc: 2.67k

add. notes: hoon won the poll i put out so i present to u my first ever enha work :3 thank u very much to everyone who voted n this will def not be the last enha fic i put out so do not worry there is much to come for hyung line!!! also icon creds to @/v4mpjay :3

. . . 

sunghoon doesn’t know how much longer he can take this. 

it all started when he began going to the gym regularly, slowly bulking his figure up and feeling himself grow out in his clothes. what used to be his lanky frame that greeted him in the mirror gradually turned into a built man with lean muscles and sharper features, adding to what was already there initially. it wasn’t like this wasn’t what he wanted though, albeit the entire reason why he even started working out in the first place being to improve his health and build better habits for himself, but the outcome wasn’t too bad in itself. he got used to feeling stronger, more lighter on his feet or less out of breath when he climbed the stairs, and it was enjoyable to know that he could lift twice his weight and still feel good as new. in some way, things felt like they were going swell.

that is, until you came into the picture.

now, sunghoon’s always known that you’re small compared to him. even when standing side by side, his height next to yours is a little laughable, though he supposes you’re used to that considering you’ve always been shorter than most of your peers. he’s well aware of how you have to go on your tippy-toes when you guys kiss, and the soft feel of your little hands in his is something that spins in his mind constantly when your fingers lace together. it doesn’t help that you always ask him to fetch your favourite mug from the top cabinet too, his larger physique towering over yours each time he leans over from behind you. he likes to tease you about it, revelling in the way you pout cutely back at him whenever he makes fun of you jokingly despite the small smile playing at your lips, but little do you know about the twisted fantasies breaching his thoughts every moment you spend together. he wonders if you would be disgusted? would you dump him and tell all your friends about what a creepy loser he was? sunghoon can’t help but imagine the worst case scenario, and it would be easy to bury these emotions down the hatchet had it not been for the fact that he’s started to think he is going mad too. 

every time sunghoon comes home from the gym, every time he enters your shared apartment, sweat dripping down his forehead and his water-bottle empty, he swears on his dead grandmother that you start checking him out. it doesn’t help that he's always been attentive either, always needlessly easy at picking up the cues of your discomfort when you're outside in a social space for too long, or being able to tell instantly when you're anything other than the happy go lucky girlfriend he usually sees you as. so, when your lingering gaze begins to trail across his arms a little too long whenever he passes your shared bedroom on his way to the shower, or when your mouth opens and closes to swallow before you're pressing your thighs together subtly each time he moves to wipe himself down each time he’s home— it all sparks something in him. it told him to finally, finally indulge in the nasty thoughts he’s kept tucked away to himself once and for all.

except he doesn’t. because at the end of the day, sunghoon is a gentleman. he pulls open the doors for you with nonchalance written all over him despite his burning ears, and he brings you back your memorised coffee order alongside a few sweet treats when he knows you’re on your period. he holds you close when you’re asleep in bed together, rubbing a gentle thumb against the skin of your cheek because he’s aware that’s what it takes for you to fall asleep, and makes sure you know he’s always going to be there for you in any time of need, even if he’s a thousand miles away. he’s never once made you doubt him, never once given you any reason to suspect he could be anything beyond the perfect, storybook written boyfriend he’s always been. 

until today, at least.

it was a day like any other, a day where you wouldn’t have expected things to take the turn they took at all. you and sunghoon were tangled up in your lavender sheets with your leg thrown over his, the morning sun streaming through the beige curtains you’d picked out on your ikea date together, and no alarms were intact to disturb you as it was the weekend. that’s probably why you both found yourselves in your current situation, your mouths meeting sloppily for short kisses and your boyfriend’s cock buried to the hilt inside you, thrusting ever so gently every other second as he whispered sweet praises to you between the meshing of your lips. the only sounds heard beyond the chirping of the birds outside your window were your soft moans and his low grunts, alongside the quiet noises of your slick dragging against his dick.

“fuck, baby. you feel so good.” sunghoon mumbles, pressing gentle smooches along the skin of your chin and jaw. you reply back something unintelligible, too lost in the euphoria he’s providing you to even form a coherent answer, which only makes him chuckle. he pulls back to admire your figure underneath him, a smile spreading across his lip at the sight of you laid out oh so pretty and pliant just for him. for him. all for his use. his use and his use only. the eventual thought makes his cock twitch inside you, and sunghoon momentarily slows down his movements in fear he’ll accidentally lose control of himself and fuck you into the sheets. his loss of momentum causes you to whine out loud though, large doe eyes blinking up at him in wonder, almost as if asking what happened, which does not make your boyfriend’s job any easier.

“hoonie, faster.” you beg softly, one hand coming up to grip his shoulder as the other bundles up the duvet underneath you. “please, wan’ it so bad.” sunghoon feels like his resolve is on the brink of snapping at your words, and he quickly resumes his previous pace (albeit still slower than what you wanted but better nonetheless) with gritted teeth, trying to think of something, anything that would distract him from the realisation of how fucking small you look under him, or how soft your hand feels resting on his skin. it doesn’t help that the sounds spewing from your lips are so cute, only spurring him on further to do what he longs to. 

“yeah, angel? want it faster? want hoonie to fuck you deeper?” he groans out instead, biting his lip at the sight of you nodding almost instantly to his words. your hole clenches even tighter around him as he speaks to you, and he shudders at the sensation. “shit, don’t do that, princess. might cum too quickly.” he exhales shakily, confused when you shake your head. “don’t care. cum f’me. wanna feel it, please.” you plead almost instantly without thinking, sunghoon’s eyes darkening as the request leaves your mouth. his pace comes to an immediate halt after that, and you make a noise of complaint at the loss of pleasure in your lower region, legs kicking up slightly in protest as you eye your boyfriend who’s currently trying to compose himself above you.

“don’t.. don’t say stuff like that.” sunghoon sighs, eyes closed shut as you cock your head to the side. you’re about to ask him why when he speaks up again. “i won’t be able to hold myself back if you do.” he professes darkly, opening his orbs back up to look deep into yours, his smouldering gaze making you shiver. you involuntary tighten around him at his confession, and he hisses at the feeling, head snapping to look down at you and the blush spreading across your cheeks. 

“i-i don’t.. don’t want you to hold back.” you mutter whilst looking away meekly before he can even comment on your actions. you meet his stare again after a beat of silence, but there’s something dark and sinister swimming in it now, and by the time you can even process what it is, he’s suddenly sheathing himself back into your warm walls, plowing into you with a heightened pace as if this is the last time he’ll ever get to fuck you. your moans tumble out of your mouth before you can even stop them, and you swear you hear sunghoon growl at the way you keen from his movements. 

“yeah? don’t want me to hold back? want me to absolutely destroy this wet cunt with my cock? ruin it for everybody else and mould it to the shape of my dick?” he grunts, a smirk spread across his face as you wildly nod at his words. “what, too fucked out to speak now, baby? where’s that confidence from before, hm?” you whimper at his condescending tone, the noise travelling straight to his core as he curses, continuing to plunge himself deep into you. the tip of his cock brushes against that spongey spot inside you, and you cry out when he angles his thrusts to hit it each time he drives inside your pussy. 

“who knew you were such a slut, huh baby? tell me, how long have you wanted me to spread you open and fuck you like i hated you?” sunghoon pants, tongue lolling out to lick at the sweat gathering on your neck. “s-so long, hoonie!” you mewl in response, eyes rolling to the back of your head when he bites down on your skin. “wanted you to— hnng, wanted you to bend me over and throw me around so bad!” sunghoon laughs breathlessly at your answer. 

“yeah, pretty? want me to use my big arms and toss you onto the bed? you should’ve told me sooner that you were such a whore.” you clench at the degrading name, and sunghoon almost stumbles into you at the sudden jolt of shock. “would’ve done everything you wanted me to. wanted it just as bad as you, did ya know that?” he grits out, pace unrelenting and unforgiving as he proceeds to pound into you. “you’re so fucking small, baby. makes me so goddamn hard every time i think about it. just want to, oh fuck— want to hold you down and make you take it.” 

“do it! do it, hoonie, please do it! make me take it, i wan’ take it for you.” you sob, and sunghoon physically feels the last of his self restrain break in half. he’s far too fucked out now to go back to his old ways, far too gone in the dizziness of making you feel good. his only goal now is to make you cum violently around him, and he’ll stop at nothing to achieve that. “gonna do it, baby. just wait, gonna fuck you so dumb, you’ll be begging me to stop.” he pauses momentarily to grab at the plush of your thigh and tosses your leg over his shoulder, resuming his past actions in the blink of an eye as you cry out at the change. he hits deeper, more harsh this way, and you swear you can feel him battering your cervix with each thrust delivered to your abused cunt.

“fuck, look at that.” sunghoon laughs in disbelief, his eyes fixed on the slightly evident bulge of his cock thrusting in and out of you in your stomach. “taking my cock so well, princess. you gonna cum for me soon, yeah? gonna cum for hoonie and make a mess of me?” he coos at the way you’re drooling, swiping a thumb up to wipe at the spit leaking out of your mouth before sucking it off, the visual of it only making you whine even more. by now, the bed is stained with your leaking arousal, but neither of you care, especially not when he involuntarily moves his hand to press down on your stomach. his movements only cause you to double over in pleasure, and before either of you know it, you’re shaking through an orgasm, thrashing and wailing as tears stream down your face.

“shit, shit, shit! that’s so hot, oh fuck.” sunghoon moans. “you did so well, angel. did so fucking good for me, you deserve a reward, don’t you? don’t you, my baby?” he rambles, and you whine in overstimulation as his thrusts grow more frantic and misplaced when he begins chasing his own release. “get ready, princess, ‘m gonna fill you up. gonna breed you so, so good and make you take it, yeah? you’ll take it, won’t you? take it so good for me like you always do.” by this point, you’re both trembling and whining out loud, sunghoon pistoning his hips into you as he desperately fixes to cum. he can feel the pressure building up, his balls tightening with each harsh thrust he delivers inside of you, and you’re more than ready to feel him ooze out of you, encouraging words spilling from your lips.

“do it, hoonie! do it, please! make me full and fuck it back into me. i’ll take it so good, so good, please baby, please.” you’re babbling by now, too fucked out to think let alone speak, but your words seem to send sunghoon over the edge because by the time you’re even halfway through your sentence, he’s shooting ropes inside of you, painting your walls white with his seed. there’s so much of it that it almost leaks out despite his cock keeping you plugged up, and you watch his beautiful face contort in pleasure, eyebrows furrowed and eyes clenched shut as he continues filling you up. 

“fuck..” sunghoon sighs out once he’s come down from his high, looking down to grip his cock and pull it out slightly only to push it back in when your cunt gushes with his release, causing him to bite his lip at the sinful sight. you whine when he moves back into you, his large arms caging your smaller frame in as he leans down to pepper salty kisses all over your face. “my good girl.” he whispers, slightly collapsing on top of you to catch his breath. his weight on you feels comforting, almost natural as you wrap your tired arms around his back tightly, pressing your bodies together even more than they already are to feel closer and connected to him.

“i didn’t know you were into that.” sunghoon speaks up after a moment of silence, causing you to open your eyes and look at him. he moves so he’s laying on his side, cock still keeping you plugged up despite the awkward position. “into what?” he deadpans at your reaction, and you giggle. “c’mon, babe. you can’t seriously look like that and expect me to not be feral for you.” you smile, and sunghoon huffs out a laugh, spooning an arm around you as he pulls your body closer to his warm one. “still, who knew my girl was so freaky?” you swat at him, and his chest rumbles with laughter, the sound sending an odd pool of warmth flowing through your chest. you both lay there in silence after that, basking in each other’s presence and enjoying the serenity and afterglow which comes from what was quite literally the best sex of your lives. 

“i love you.” you hear sunghoon mumble suddenly, his voice drowsy as he yawns cutely, a large grin spreading on your face at the simple three words which leave him. you reach out for his hand, lacing your small fingers in it before bringing it up to your mouth and pressing a kiss to the back. “love you more, hoonie.” you sigh out in satisfaction, eyes slipping shut slowly as sleep welcomes your tired senses.

you gradually drift off, thoughts filled with sweet dreams of your boyfriend and his precious laughter. 

. . .

comments and reblogs are always appreciated! <3

[reasonsforhope]

"Engineers at the University of Pennsylvania have made a critical breakthrough that promises better outcomes for pregnancies threatened with pre-eclampsia, a condition that arises due to insufficient blood flow to the placenta, resulting in high maternal blood pressure and restricted blood flow to the fetus.

Pre-eclampsia is one of the leading causes of stillbirths and prematurity worldwide, and it occurs in 3 to 5% of pregnancies. Without a cure, options for these patients only treat symptoms, such as taking blood pressure medication, being on bed rest, or delivering prematurely—regardless of the viability of their baby.

Making a decision to treat pre-eclampsia in any manner can be a moral conundrum, to balance many personal health decisions with long-standing impacts—and for Kelsey Swingle, a doctoral student in the UPenn bioengineering lab, these options are not enough.

In previous research, she conducted a successful proof-of-concept study that examined a library of lipid nanoparticles (LNPs)—which are the delivery molecules that helped get the mRNA of the COVID vaccine into cells—and their ability to reach the placenta in pregnant mice.

In her latest study, published in Nature, Swingle examined 98 different LNPs and their ability to get to the placenta and decrease high blood pressure and increase vasodilation in pre-eclamptic pregnant mice.

Her work shows that the best LNP for the job was one that resulted in more than 100-fold greater mRNA delivery to the placenta in pregnant mice than an FDA-approved LNP formulation.

The drug worked.

“Our LNP was able to deliver an mRNA therapeutic that reduced maternal blood pressure through the end of gestation and improved fetal health and blood circulation in the placenta,” says Swingle.

“Additionally, at birth we saw an increase in litter weight of the pups, which indicates a healthy mom and healthy babies. I am very excited about this work and its current stage because it could offer a real treatment for pre-eclampsia in human patients in the very near future.”

While further developing this cure for pre-eclampsia and getting it to the market for human use is on the horizon for the research team, Swingle had to start from scratch to make this work possible. She first had to lay the groundwork to run experiments using pregnant mice and determine how to induce pre-eclampsia in this animal model, processes that are not as well studied.

But, by laying this groundwork, Swingle’s work has not only identified an avenue for curing pre-eclampsia, it also opens doors for research on LNP-mRNA therapeutics addressing other reproductive health challenges...

As Swingle thinks ahead for next steps in her research, which was funded by the National Institutes of Health and the National Science Foundation, she will also collaborate to further optimize the LNP to deliver the mRNA even more efficiently, as well as understanding the mechanisms of how it gets to the placenta, a question still not fully answered.

They are already in talks about creating a spin-off company and want to work on bringing this LNP-mRNA therapeutic to clinical trials and the market.

Swingle, who is currently finishing up her Ph.D. research, has not only successfully led this new series of studies advancing pre-eclampsia treatment at Penn, she has also inspired other early career researchers in the field as she continues to thrive while bringing women’s health into the spotlight."

-via Good News Network, December 15, 2024