#Geriatric Population

[prachicmi]

Biopharmaceuticals: Driving Innovation in Healthcare Industry

Significance in Drug Development Biopharmaceuticals, also known as biologics, are medical drugs created by living organisms through biotechnology methods instead of being chemically synthesized. They have revolutionized the treatment of various diseases over the past few decades. They are often developed to treat complex diseases like cancer, diabetes, rheumatoid arthritis that cannot be effectively treated with traditional small molecule drugs. They provide targeted treatment options with fewer side effects compared to conventional drugs.

Mechanism of Action of Biologic Drugs Biopharmaceuticals work differently than chemically synthesized small molecule drugs. Their large and complex molecular structure allows them to be highly specific and interact with the body in novel ways. Most biologics are protein-based and are produced through recombinant DNA technology, monoclonal antibodies, tissue engineering or gene therapy. They target disease pathways at the protein level using their three-dimensional molecular structure. For example, monoclonal antibody drugs bind only to specific proteins on the surface of diseased cells like cancer cells, making them an effective targeted therapy. Due to their specificity and high molecular weight, they cannot be chemically synthesized and require biotechnological manufacturing methods. Advantages over Conventional Drugs The complexity and specificity of biopharmaceuticals provide several therapeutic advantages. Firstly, they demonstrate high efficacy against diseases that were previously untreatable. Secondly, biologics elicit weaker immune responses than foreign therapeutic proteins derived from non-human sources. This allows them to be highly effective with fewer side effects. Thirdly, biologics can be engineered to have longer half-lives in the body compared to chemically synthesized drugs, reducing dosing frequency. Fourthly, they demonstrate precise targeting of cellular pathways involved in disease without impacting healthy cells. This enhances safety and tolerability. Lastly, biologics development allows for personalized medicine approaches through companion diagnostics, biomarker-guided therapies and combination treatments. Biosimilars Foster Healthcare Access and Cost Savings The development of biosimilars, which are highly similar versions of innovator biologics that have lost patent protection, has been a major driver of cost-savings in the biopharmaceutical industry. Biosimilars can be approved by regulators based on demonstrating similarity to an existing approved biological product through analytical, animal and clinical studies, without having to repeat the full clinical development process. They provide an opportunity for more affordable treatment options for patients once the high research and development costs of originator biologics have been recouped. Global biosimilars market is projected to grow at a CAGR of 28% till 2027. Companies producing biosimilars play a key role in expanding access to biologics and reducing healthcare expenditure burdens for governments and patients. Challenges in Manufacturing Despite the advantages, realization of full potential of it faces certain production and regulatory challenges. Firstly, manufacturing biologics involves complex living cellular systems making standardization and scale-up more difficult than chemicals. Secondly, quality by design approaches and stringent controls are required to ensure batch-to-batch consistency. Thirdly, characterization of complex protein structures with analytical techniques is challenging. Fourthly, the high development costs along with regulatory requirements for extensive clinical testing impacts drug pricing. Fifthly, storage and distribution of biologics requires temperature-controlled cold chain management due to susceptibility to degradation. Lastly, the possibility of immunogenicity on repeated administration and product withdrawals due to manufacturing issues pose risks. Ongoing technological innovations are helping address these challenges to some extent. Impact on Future Drug Discovery Biopharmaceuticals have expanded treatment horizons by enabling therapies against previously "undruggable" targets. Areas like gene therapy, stem cell therapy and tissue engineering hold promise for future disease modifications. The application of artificial intelligence, machine learning and digital technologies is expediting biologics development through in silico screening, protein design and manufacturing process optimization.

Get more insights on, Biopharmaceuticals

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[gauricmi]

The Global Geriatric Medicines Market Growth Is Driven By Aging Global Population

The global geriatric medicines market refers to drugs and medications that are specifically formulated and developed for elderly patients aged 65 years and above. Geriatric medicines are medicines that are effectively and safely administered to the elderly population who are prone to multiple chronic diseases and conditions. The medicines are often available in user-friendly formats and doses suitable for senior citizens with challenging swallowing patterns or other health issues.

The Global Geriatric Medicines Market is estimated to be valued at US$ 1,570.18 Bn  in 2024 and is expected to exhibit a CAGR of 6.6% over the forecast period from 2024 to 2031. Key Takeaways Key players operating in the Geriatric Medicines Market are Pfizer Inc., Takeda Pharmaceutical Company Limited, Janssen Pharmaceuticals, Sun Pharmaceutical Industries Ltd., AbbVie Inc., Boehringer Ingelheim, Eli Lilly and Company, Bristol Myers Squibb, Daiichi Sankyo Company, Limited, Bausch Health Companies, Mallinckrodt Pharmaceuticals, Endo Pharmaceuticals, Eisai Co., Ltd., Ferring Pharmaceuticals, UCB, Evoke Pharma, Cadila Pharmaceuticals. The increasing prevalence of chronic and lifestyle diseases among geriatric population is expected to drive the market growth during the forecast period. Pfizer, Boehringer Ingelheim, Roche, Novartis are a few top players operating in the geriatric medicines market. The global geriatric population is rapidly increasing and is expected to witness the fastest growth in developing economies of Asia Pacific and Latin America on account of improving life expectancy and declining fertility rates. This substantial rise offers huge potential for drugs and therapeutics that are specially designed to cater to the elderly population. With a large elderly population base, there exists vast growth opportunities in countries with aging populations such as Japan, Germany, Italy, France, the United Kingdom, and the United States, among others. Market drivers The global aging population is the primary driver propelling the growth of the global geriatric medicines market. According to the United Nations, the world’s geriatric population is growing rapidly and is expected to double from 12% to 22% between 2015 and 2050. The rising prevalence of chronic diseases such as cardiovascular diseases, cancer, diabetes, arthritis, osteoporosis, neurological disorders, dental and oral diseases among geriatric population significantly contributes to the growth of the market. Manufacturers are focused on innovations to develop advanced treatment solutions for diseases predominantly affecting senior citizens. Favorable government policies and regulations further support the growth of the geriatric medicines market.

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[escape-reality-and-be-free]

…..

Biden hasn’t called for a fucking ceasefire yet and I think that matters monumentally more than whatever this bullshit is.

Also, Biden didn't plot and execute a coup that thankfully failed.

Also Biden hasn't announced that he's going to build camps and force undesirables and "vermin" to live in them.

Also Biden isn't facing 91 felony indictments.

Also who gives a flying fuck that Biden is three years older than wish.com Hitler?

Biden is not a Fascist, and the other guy is.

THAT IS THE ONLY THING THAT MATTERS.

[artisticdivasworld]

The Future of Nursing

Hey there, fellow nurse! Let’s chat about what’s in store for our profession in the coming years. It’s going to be quite a ride! First off, we’re going to see a lot more tech in our day-to-day work. Think artificial intelligence, telemedicine, and electronic health records. We’ll need to get really good at using these tools, not just for patient care but also for things like data analysis and…

[gallium-spoon]

Today a patient told me "I have to remember I'm not as young as I used to be, I can't just do what I want and bounce back from things like I could when I was 50"

Really put things into perspective

[rodrickheffeley]

watching American leftists blame everyone for Kamala losing instead of the majority white American population who voted that orange geriatric back in the office

[basiliomagnus]

This quote made me think, how do you think tastes and styles of cooking differ between the tribes? Each party member has their own style of food, but Eupha and maybe Heismay are the main ones who we could extrapolate things about their culture from.

I think that paripus food definitely uses the most spices. Rhoag food uses the least

oh im so glad at least one person asks me this i've been thinking like. too much about tribe culinary profiles lately

so to start a while ago i tried to group all the principalities into their climates and ecosystems right. aside from the fact roussainte are fuckin everywhere from what we know:

oceana has a healthy fishing business and is mostly woodland, through they have a small stretch of arid land from central euchronia

central euchronia is high in desert and (presumably) arid soils, though for the purpose of sustaining grand trad let's say that south euchronia contains fertile wetland

montario is extremely mountainous and cold BUT it also has that patch of thick forest though a lot of the fauna there are like. venomous and spit fire

virga island

so when i think about the food part of their cultures i tried to keep in mind where a majority of the tribes seem to be located and how that would have impacted their culinary development, assuming that the population has been relatively consistent since the annex war. there's also their individual values to consider (VERY LONG UNDER CUT)

clemar are like, white brits, so i think assuming they have similar food to irl england is a good starting place. thanks to central euchronia having the desert climate it does however i think mostly in oceana do they have fish as part of their meals and in grand trad its mostly a delicacy. a lot of local dishes that are made up of what can be found lying around, nothing too complex, but due to the nature of where grand trad Is i think they lack a lot of real "desserts" that aren't considered a luxury (sugar is expensive)

roussaintes NEED high protein meals to sustain the amount of physical work they do, so i think meat and leafy green vegetables are a staple in most dishes. lentils, tofu (soybeans are actually really protein dense), nuts, the like. roussainte in montario probably have a lot of spice in their meals for cold weather but to also manage their appetite during military work.

rhoag are a tricky case but hear me out: i feel like a lot of their food takes after other tribes due to how long they live. it's probably customary for a rhoag to wander around a lot in all the time they have to live, so a lot of what they cook ends up influenced by all the other tribes in different ways. as for methods i imagine that they focus on recipes that don't require much physical labor (spending most of your long life in your geriatric stage probably isn't great), so a lot of soups, pan fried stuff, grilling, etc. is probably shared around.

ishkia are almost 100% spice fiends, if you're like me and assume they have bird-like traits in a lot of places they probably have much higher spice tolerance than most other tribes, in addition to their climate requiring warmer meals. a lot of farmwork is probably done down in the lush forest area because mountain farming is historically a bitch and a lot of Brain Food can't be grown in the cold. heavy "brain food" presence in casual meals (fatty fish, coffee, collard greens). a lot of roots, mushrooms, and foragables that grow in cold climates (snowpeas, watercress, acorn, etc) at high altitudes are common, though this sounds horrible bc you cant really Get them anywhere else in euchronia.

nidia because of the Everything read to me as having a high dependence on magla-rich food and stuff that grows low to the ground. a lot of root vegetables (carrots, potatoes, turnips) and berries (straw, blue, the likes) that can be infused during the growing process. lot of emphasis on eye health on that note (leafy greens, citrus, probably raise a lot of chickens for eggs in their villages). theyre very fae folk inspired to me so i imagine a lot of their delicacies are an important part of their culture (muffins, candied flowers, tarts, yknow)

paripus probably take a lot after recession foods given their status and wide-spreadedness, a lot of cheap options like rice, beans, grains, fruits and meat dried. however i also see them as having a large amount of "leftovers" or "community" foods yknow? stuff like hunters stew or bread pudding or salads, generally stuff you can make with what's left over after a big meal and you can share with other people. i think they probably have a lot of "loose" recipes with easy replacements or things you can swap out if you don't have them.

eugief society is analogous to japanese culture if you look at the architectural styles of heismay's village and his clothing so they probably have a lot that's taken from there haha. fish, savory foods, big on spices and they probably invented some form of oil frying. i imagine that the area between oceana and euchronia is heavy in rice production due to the hot and humid climate, on that note

mustari are very analogous to southeast asian/pacific islander culture! lot of rice, game, seafood, emphasis on pairing sweet with salty or savory. i imagine a lot of steamed or roasted foods. mustari that came to the capital or montario probably ended up having to mix traditional styles with the ones present there, esp due to the lack of ingredients that were only capable of being found on the archipelago (side note: here's a nice article about this stuff that i found interesting)

as for elda theyre like. they remember shit from the old world. i know this probably just means they understand how to cook meat the best and get how to properly process certain foods with what cooking material but what if will came out and showed people how to make french fries. imagine

[perseephoneee]

Ice-scating with Diego Hargreeves please 🥺

ice skating (diego hargreeves x gn!reader) ficmas 2023

꒰ ࿁ ˙ ˖ ໑ happy day 3 of ficmas!

a/n: sorry this one is so short, but i hope it still brings all the holiday fluff vibes that are necessary.

↳ masterlist  ↳ ship exchange ↳ join my taglist ↳ ficmas 2023

“You’ve got to be fucking kidding me.”

Diego glared at the ice skates in his hand, looking at the rink currently populated by families, teenagers, and even the geriatric population. He didn’t want to ice skate. He didn’t want to be here at all. Except that you wanted to ice skate because “the-world-is-ending-and-if-we’re-all-going-to- die-I’d-like-to-do-this-with-my-boyfriend-once.” He had never been that good at turning you down. He just also wasn’t that good at ice skating. You, on the other hand, were a freaking angel. Diego couldn’t peel his eyes away as he watched you glide across the ice, smiling. You even managed to turn backward and let the skates take you. He hadn’t seen you laugh in a long time. You ended up sliding right over to him, hands stopping your motion against the wall as you stared at Diego sitting on the bench. 

“Are you going to ice skate or what?” You raised a brow, looking at your boyfriend in amusement. 

“I’m working on it.”

“You’re terrified, aren’t you?” you chuckle, poking him in the shoulder as he swats you away. 

“I’m not,” he snaps, letting out a huff of air. “Just…never done it before. Don’t want to embarrass myself,” Diego mumbled. You leaned over and took his hand in yours, your mitten-clad hand enveloped in his own. 

“You won’t embarrass yourself; you have me,” you smiled before gesturing back to the ice. “Plus, Klaus is embarrassing himself all on his own.”

True to your word, Klaus was prancing across the ice like no one's business. It's not that he couldn't skate (he was excellent). He was acting like he had taken shrooms before getting on the ice. Knowing Klaus, he likely had. His arms were wiggling around as he balanced on one leg and spoke out loud the whims and wiles of the ice. You were glad he was having fun, even though Diego was annoyed that Klaus had invited himself (again) to another one of your couple activities. 

“Please? We can get hot cocoa after,” You pouted, and with an eye roll, Diego finally relented. He tied on the skates and wobbled to a standing position, hobbling over to the entrance. You held out your hands, reorganizing your stance so you could support him if he started to fall. Diego slipped a little as he grabbed the wall and your hand, a panicked sound leaving him. “You gotta bend your knees, don’t freeze up.” He let out a hiss, which made you laugh, but he hesitantly moved one foot in front of the other, letting the ice carry him around the perimeter. You skated right next to him, reaching out occasionally to keep him studying. Eventually, he started to relax, and you smiled as he got the hang of it. Diego laughed excitedly as he let go of the side wall. He even whooped as he made his first lap without any help. By the second time around, you skated and grabbed his hand, interlocking your fingers with him. 

“Thanks for indulging me,” you said, looking up at Diego. He could be a stubborn ass at the worst of times, but he always made you feel supported in ways you hadn’t experienced before in your life. Diego brought your enjoined hands to his lips, pressing a kiss to the back of your palm. 

“Ice skating is pretty cool,” Diego admitted. “Manly, since it has blades.”

“Oh, absolutely,” you chuckled, waving as Klaus circled you. To cause mass chaos, which you were starting to think was Klaus’ mission in life, he reached out for Diego’s open hand and dragged the two of you behind him. This didn’t work out with the intended effect and instead led to all of you sprawling across the ice like a hockey accident. 

“Klaus!” Diego growled, reaching to beat up his brother. Klaus rolled away, sending an apology as he skated away. Diego crawled over you like a starfish on the ice as you lay. “Are you alright?” You smirked instead of answering, grabbing the front of Diego’s jacket and kissing him. 

“I’m perfect,” you laughed. Diego kissed you again before helping you up, letting you lean against him as you shuffled over to the side of the rink. “Should we get hot cocoa now?”

“Oh, yes, please,” Diego huffed, helping you off the rink and holding your hand to the hot cocoa stand the entire time.

[losersimonriley]

The neuro ward smells different. Better than the ICU. Less like piss, more like hand sanitiser–which doesn’t make much sense, considering ninety percent of the population on this floor seems to be geriatric, but he’ll take it.

Forgot to share chapter 10 here~

[iilines]

I have been thinking about the Ninth house population.

We know from Gideon's narrative, everyone there is geriatric or at least old from her perspective.

We also know that an entire generation died for Harrowhark's creation. Leaving only Gideon, Harrow, and Ortus. But why were there no other children born after that?

We had at least 20 years to repopulate another generation. At the very least the youngest parents could have been 20-25.

All I could think, was, the population that was there left in a mass exodus after being forced to sacrifice their offspring, leaving only the most devoted followers of the tomb. (Clearly the elderly)

This leads to our Ninth houses signature spell. The Sewn tongue. The population could only leave if they consented to the silenceing ritual, burying the reverend father and mothers heinous secret. But also allowing them the opportunity to discourage pilgrimage.

[breadandblankets]

duke and damian like going to the park together, duke goes to play chess against Gotham's geriatric population and Damian is going to feed the birds

[suisen-shira]

My middle aged neighbour stays in the Philippines for most of the year. He casually mentioned the epidemic of musty retiree men from the West shacking up with late teen/early 20s Filipinas who are nearly always from impoverished backgrounds. He described it as a 'win-win', old man gets to ravish her youth plus lifelong nurse to change his diapers, she finds a way out of her poverty or at least a better quality of life.

I told him it's a hooker punter arrangement and that these men don't dare return to the West with their 'wives' in tow because their main leverage over her comes from her desperation. I noted how women from my country (industrialised) do not have to resort to such arrangements as frequently and the trend in Ph stems from penury. They could just NOT be rapacious and hire her as a nurse but why would they when they can get bang-maid benefits rolled in?

He proceeds to call me opinionated and says women from my country (say, the US) are too ugly to galvanise the mass exodus of geriatrics for companionship purposes. He then smugly explains to me that prostitution is, for the most part, not exploitative, attractive women would anyday prefer to be paid 1000s for being a pillow princess than work at Subway (nevermind the frequently supermodel tier women working in retail and hospitality). How, while 's__king disgusting men's d___s for a living' would certainly be no fun, the (Filipina) women he knows that do it are chirpy, wholesome, pretty college girls looking to earn a few extra bucks. That it is a personal liberty and I am projecting my biases on to them by suggesting such encounters may be degrading and traumatic for them.

It's all just a naughty adventure, you see. A luxury available only to beautiful women in their wild days of youth. A mandatory 304 phase, if you will. Why not get paid while you're at it? Imagine being so desirable men pay lavishly to have you. Happy hookers ftw. Because sexuality is divorced from privacy and self respect when it comes to beautiful women. The highest bidder wins.

These girls will go on to marry wealthy men and have kids (thereby scaling the pinnacle of womanhood), he explained. As if making oneself into a sex object is a rite of passage for attractive women, a pitstop before hallowed wifedom where the lewd husband continues to consume 🌽 and prostitutes while telling wifey he wouldn't dream of disrespecting her the way he does THOSE women, she is The Wife, the social position is the reward.

His talking points boiled down to 'attractive women are in possession of a goldmine, wouldn't it be a criminal waste for them to not monetise their bodies in the most invasive manner possible?' He earnestly believes beautiful young girls are available on tap if you are a wealthy men*.

*He is a wealthy man.

He, like so many other leches populating the corridors of corporate power, has made bank. Otherwise unremarkable, he is not a looker and although this post does otherwise, the less said about his nauseating personality, the better. I suspect it is his dirty old man fantasy, an assembly line of stunning, young women ever-eager to f___ him, his general unsavouriness notwithstanding.

Throughout his tirade he wouldn't let me get a word in. He absolutely would not entertain the notion that passport bro bs and sex for money is inherently misanthropic. When I pointed out that it is a combination of low self-esteem, insecurity and economic instability that impels women who claim to 'voluntarily' sell themselves, his response was: 🤷🏻‍♀️ at least they are making something out of a gnarly situation instead of acting like professional victims. The specious 'emancipation' argument. He will do anything but admit that all of it, from bubbly 'college girls' su___ing 🍆 for cash to the long-suffering, self effacing wife grateful for scraps of 'love' is an outcome of the self-serving male psyche; the unbridled lust and entitlement to women it breeds.

As though an exclusive, loving heterosexual partnership founded on mutual support and regard is a pipe dream. By signing up for it, women accept the fineprint - his roving eye and insatiable sexual appetite, the unrelenting assaults on her soul.

Going by my neighbour's assertions, objectifying women, the pursuit of no strings attached/hedonistic sex is a compulsive behaviour for human males, an inalienable part of male sexuality that is also divorced from their capacity to love. Women are either Madonnas or Wh__es. The former should be thankful men elevated her to the latter, her superior status implies he adores her even if his actions show anything but. He is simultaneously free to covet the latter, she gets his attention and admiration - a 'win-win'. Both exist to satisfy different facets of the male psyche.

I'm sad to report that even this odious man has a devoted long term girlfriend whom he frequently derides. She is always in damage control mode putting out the fires he starts with his unconsidered words. She can do better but she stays because 'the known devil etc'. Being single is inconceivable for some reason.

He is one of those men that takes pride in being obnoxious, like it is a reflection of his importance, his ability to hurt others evidence of his emotional intelligence. People tolerating his unkindness are tacitly declaring their allegiance to him. Of course that is not the case, like so many men, he has an ill formed Theory of Mind. Most people just pinch their noses and want to be done with the unpleasantness asap, confrontation (I found out the hard way) only prolongs the suffering - and all for naught. He is too daft to know better.

[stevenbasic]

Growing into the Job, Post 353: That was Then, This is Now, p5

Melissa was crouched down alongside me, excited about giving me this virtual tour of the new office spaces using her laptop. She was positively beaming, and her size made me feel like a child with his pretty teacher as I sat like a kid at my oversized desk that Monday morning. I’d normally struggle with keeping my eyes from drifting down into the neckline of her low-cut white dress, but I was rapt in awe, and more than a little apprehension as I stared at the screen. I struggled to grasp at the sheer scale and enormity of this thing. I hadn’t seen anything about this before, believe it or not. The girls hadn’t let me even step foot on the construction site for the past few weeks - ‘it’s a surprise!’ they’d said, but I suspect there was more to it than that - so all I’d seen were the early blueprints before things really got started. Even those were ridiculously extravagant, and impossibly adventurous, but this…this looked even more incredible.  Did she say it was almost finished??

She'd just shown me the interactive, digital replica with the soaring, Roman-temple inspired atrium with its jaw-droppingly huge statue of M-…of, uh, ‘Female Health’ towering over a new, opulently modern reception desk. The glass ceiling left the whole space awash with sunlight. Then she showed me the humble new entrance to our old practice here. It was left virtually unchanged as if they had simply built around it. Melissa assured me that this was so things would stay nice and familiar for my geriatric patients, but I couldn't help but notice how small it looked. It was completely dwarfed by the grand entrances and size of whatever the hell was going to be going on in those two new wings of the building.

Turning the camera around, Melissa ‘walked’ us by the desk and over to face the entrance to the ‘Evolution Wing’. She explained to me that this area of the walkthrough wasn’t populated with imagery yet, so its onscreen doors remained locked. 

Huh. Apparently that area would be for continuing pharm studies, etc. I guess I wasn’t clear on why they need a whole wing for that, but whatever. How much research did they really need us for? Well, it’s their money. Theirs…and my ex-wife Sheryl’s. Who, with her enormous wealth, technically owned this entire building.

Speaking of which, how this whole thing got funded was beyond me; this company’s pockets seemed limitless. But, I reminded myself, I’d decided to stop worrying about it weeks ago. There’s nothing wrong with growing the practice, is there? Growth is good, bigger is better…

I suddenly noticed my eyes had, as if on instinct, finally drifted down Melissa’s top. 

“Let’s check out the ‘Women’s Health’ wing!” she sang, bringing my attention back to the screen. Our camera made its way towards the rear of the atrium, under the imposing presence of the giant statue, and into a well-lit suite of separate clinics. Each one had their own separate entrance from the main wing. Down this impressive hallway I saw signs for ‘Internal Medicine’, a ‘Fertility Clinic’, even an ‘Aesthetics Center’, where Melissa told me Karen, the new APRN, would run a squad of cosmetic nurses and plastic surgeons. And… “We’ll have an ‘Adolescent Care’ department’?” I asked, baffled at the scope of what this place was soon to be.

“Sure yes of course!” Melissa lauded, excited, “Even the youngest women will need a place to come where they can be encouraged to, like, grow into everything they can be!” She sounded like she was reciting something that had been told to her, for sure, but whatever it was it was clearly something she believed.

“But, pediatrics?” I pressed, incredulously.  Frankly, I was afraid of how far away things were getting from geriatrics, the specialty of my practice. Far Horizons was drifting, and soon I was going to lose even more of the little control that I still had.. 

“Oh, you’ll see, this won’t be just kiddies and boo-boos,” Melissa continued, “this’ll be where girls are taught and trained and, like, developed into what this new, changing world is going to need. Strong and confident female leaders, scientists and athletes, young women that can take care of things. It's important that they become healthy, empowered women who can lead us into the future.” Again, it sounded like a marketing angle, but one that had obviously already worked.

The camera passed through the doors into the ‘Adolescent Care’ unit, and I was shown a small, but beautiful new waiting room, a modest gym, and several well-appointed, modernly elegant exam rooms. Further in I spotted a procedure room along with  what looked like several offices for new providers. This was obviously concerning, but before I could really think about it my attention was pulled away by something in the air, away from the screen and settling, once again, down into Melissa’s cleavage. Her big lungs swelled her breasts up with every breath, and a new wave of perfume had drifted up from her flawless, velvety skin. Breathing her in felt…good. It helped me relax and forget my worries.

Melissa was, no doubt, enthusiastic from the start to show me this virtual tour, and she seemed to be getting more and more excited as we went along. I could tell she really wanted to show me something, but all I could think was: You smell really good. 

“Thank you,” she said, and continued talking. “But speaking of what the new world’s going to need, let me show you this!” she twittered, quickly now backing the camera out and away from the adolescent unit. A new door came into view, further down the main hallway of the new wing. “We even have a small clinic for men, too, a little place for them inside us,” she said, “And here it is!”

I squinted at the door, not really comprehending what I was reading on the small sign aside it. 

“‘R-regression Clinic’??” I asked, my radar suddenly up, “What’s that?”

“Oh, Jay, I can’t wait!” Melissa beamed, bouncing a bit on her haunches and sending new jiggles through her upper chest, “Haven’t you heard? It’s the newest thing, a new movement in therapy to help couples really bond, get them closer, open up, like, new pathways of communication, break down barriers.” Our camera stepped right up to the doorway but Melissa stopped us there. “Katerina and Shanette have done such a good job setting it up. The counseling rooms and procedure areas are really nice but, y’know what?” she continued, smiling with giddy anticipation, “I'm going to save showing those to you ‘til we can do it in person. I already booked an appointment for us!”

She what??

“In fact, we can save the rest of the clinics for when I show them to you for real,” she said, “In the meantime, why don't we check out the basement.”

“The basement?” Couldn’t be too much down there, right? At the time the basement of the building had been used for some storage.

“Yeah, it’s incredible what they’ve been able to do. Expanding it I mean. You must have heard the blasting, all hours of the night? They’ve added in two…or, wait, is it three?…new sub-basements. Like whole new floors.”

I watched as the camera quickly sped down a hall and up to an elevator. Even in this mock-up walkthrough, we had to wait a moment for the elevator in the hall to bring us down to another floor. Whoever designed this must have been a real stickler for details I thought as we waited for the doors. Melissa, I noticed, could barely keep herself still. When the doors finally slid open and we stepped in, she took us down past the first basement levels down to the very bottom before mentioning that the virtual walkthrough didn’t have images for the pool yet. 

“Wait…There’s a pool?!?” I asked, in disbelief.

“Yes, of course silly,” she giggled, “on the first basement level. I’ve told you about that! You’re so cute, so scatterbrained. I love that! But, yes - pool! For trainings and exercise, and there’s a nice hot tub that I think the Regression Clinic is going to use until theirs is finished."

I felt a chill rise up my spine as I thought about the last time I was in a pool.

"Don't worry, sweetie, you’ll be safe,” she assured me, “Men aren't even allowed onto that level unless there’s a lifeguard on duty. That reminds me - we have to hire a lifeguard!” Melissa giggled, maybe picturing exactly what I was, a hot young thing in a red swimsuit. “Now, The other levels aren’t for patients, it’s like cubicles and computers and stuff, and they’re supposed to be for girls-eyes only. But I’ll show you the bottom one anyway. It’s so cool!”

“What’s down there?” I queried, as the elevator hit the bottom floor and the virtual doors slid open. 

“So far it’s a place for the construction workers, a whole floor,” she began. In front of us was a big, simple, starkly lit room that looked like something of a community space, a common area with large tables and benches. Like what someone might see in a school or church basement. Or a prison. 

“A lot of them…well, all of them really…have stopped going home at night. Like, when their shifts are done they just keep working. They’ve just started camping out among all the construction when they need to sleep, and just wake up to work. They feel better here than they do…out there.” Along with the weirdness of what she was describing, Melissa giggled strangely. “I guess they just like it here so much! Even the ones with homes still would rather stay here now.”

“For real?” I asked, incredulously, but suddenly I was reminded of the queasy feelings I got when I stepped outside for too long, and a looming sense of dread began to  slowly creep over me. There was something terrifyingly wrong about all of this, but at that same time it was all darkly thrilling. I watched the screen as the camera slowly came out of the elevator into the big, open common room. Unlike the upper level, the ceilings here were low, and though the area was likely the footprint of a small gymnasium, it felt strangely claustrophobic. 

“Yeah. But, the construction’s almost done,” she continued, as we drifted in among the plain plastic chairs around a simple round table, “and some of them are homeless now, and the rest don’t want to leave. So, we decided to make a place for them, and any other men we hire. If they need a place to stay."

That surprised me. “Hiring men?”

“Oh, for sure! I mean, we’ve been interviewing and hiring for so many new positions. Girls, of course, for the clinics, the administration and blah blah. But Evolution wants to do some community outreach, help out the less fortunate,” Melissa continued, “So many men are unemployed now, and we figure we can use them for maintenance, cleaning, laundry, landscaping, right? Maybe even some basic data entry in one of the lower levels.” 

“I…I guess?” I answered, still disbelieving what I was seeing and hearing. 

“…and some of these construction workers are pretty cute,” she giggled, as the camera brought us to one of several doorways at the back of the room, “the girls kinda want to keep them.” This entry led to a low hallway off of which came a number of hostel-type rooms. Each room had multiple iron bunk beds, allowing each to sleep a dozen, maybe more. “Just look at these cages I’ve made for them…”

“C-cages?” I blurted, suddenly noticing now that, yes, the doors to the rooms were barred, like a jail’s might be. 

“Well, haha, not cages!” she quickly corrected, “We just…want it to be secure, and safe, right? If there’ll be men living here, underground, we don't want them getting into trouble do we?”

“O-okay…” I hesitated, trying to come to the logic of it all.

“They're more like living areas…” she added.

…than, like… some sort of pen? Yikes. But… there was some charity in it I guess. If these men were homeless, and without work, weren't we just doing them a favor? They seemed to like it here. 

The camera looked further down the dark hallway. There were lots and lots of these rooms. “How many of these people will be living down here?”

“Well, right now we think there’s about twenty surviv-…A-about twenty of them. Plus we have plans to bring in about a dozen right away.” she answered, a strange tilt to her voice, some heavier breathing as she turned the camera around to go back to the common area, “But we have plenty of room for a lot more once we need it.” She was excited for this, for sure, and trying to hide it.

“It…it  looks nice,” I tried, just imagining what the real thing would look like in person as I did  and doing my best to ignore the lingering sense of foreboding, which continued to breath chills onto the back of my neck. Something about this wasn't quite right.

“It will be pretty nice for them,” Melissa continued, as she breezed the camera past what looked like a small cafeteria. “It’ll be our own little far-...our own little community of men. We’ve included a few more feeding areas, back that way, all sorts of…uh, like, games and places for them to explore and hang out when they’re not working.” The camera was sailing through a labyrinth of smaller spaces, now, little halls. A room of video games. “They seem to like looking at pictures but they won’t have phones or computers…”

Because they can’t afford them? Or because you won’t permit it? I didn’t dare ask.

“...and haha we noticed that now that we have the statue up in the atrium, they spend a lot of their free time at night hanging around, sometimes even kneeling in front of it,” she explained, “but we can’t have that anymore so haha we made a little room with a smaller version of the statue that they can go to.”

“Another statue of you?!?” I asked, totally flabbergasted at what I was seeing. The camera had glanced into a small, dark chamber, lit by flickering, computer-generated candles. Indeed a smaller, maybe eight-foot tall copy of ‘Female Health’, stood inside. Made of a similar white stone amalgam perhaps, this one was placed in more heroic of a pose. It stood on a raised platform at the far end of the room, to look down at its admirers. “For them to….what??” Jerk off to you?!? “Down here?!”

“Remember, it’s not me!” Melissa giggled, as the camera backed out of the room, “You don’t have to be jealous!” 

Is that a sign above the door? They call that ‘The Chapel’ ?!?

I looked to my right, to Melissa, still squatting aside me. If I hadn’t noticed it before, I did now. Her dress today was toga-inspired, for sure. She looked like a Roman goddess, unsettlingly too much like the statue even now, here. 

“And, don’t worry, I’ll make sure they behave,” she continued, as our point of view on-screen shifted, “I have cameras everywhere, so I can watch over them. I'll make sure they’re nice and safe.”

…and not doing anything you don’t allow, I gather?

“Okay well speaking of staying safe, I can’t wait to show you where you’ll be living!” Melissa said ebulliently. She was moving the camera around a bit through the men’s chambers again, and I was suddenly afraid that she’d had a cell set aside for me down there, in the depths. “But the upstairs isn’t done yet. We’re still working on finishing the design and moving the walls around. Especially the third floor.”

“I’ll be u-upstairs?” I asked, feeling a sense of immediate relief. Had I known I’d be moving? 

And the building has three floors now?

She sensed the change in my voice and giggled. “Yes of course, silly! You’ll be living upstairs, cutie, with me and the girls,” she said, as she moved to click a few keys and the animation of the virtual walkthrough closed off her screen. “There’s a big suite planned for me, and you’ll have your own ca-...your own little room inside it.” Crouching alongside me, she shifted a bit. “It’ll be so nice, when…when I can take you back to my new nest, I can make it all so comfy for you,” she said, and I heard the first hint of the throaty growl that signaled her arousal. “We’ll move all your stuff in, or just get rid of it all,” she said, making herself even more excited with the thought of it, “I’m going to have everything you need, get you anything you want. Mmmm….rrrrr….”

Oh…oh crap…   

Jesus I was getting so hard.

“Oooo just the thought of it is getting me all kinky haha,” she laughed, “Mama’ll take good care of youuu….”

Oh god.

I saw Melissa glance up at the camera, which Gianna had been using earlier in our video chat and had since stood forgotten attached to my desktop’s monitor. She’d clicked off power to the screen, but the camera’s red light still blinked. Melissa smirked.

“Mama and her girls, her huge, huge hive of girls,” she continued, in a tone that had started to sound like gloating as she settled her hand on my iron-hard cock, though my thin, ripped scrub pants. “We’re getting so big, here, our little home. And we’re going to be…nnngh…hiring. Hiring more. Hiring so…many…more…girls…”

“Oh jesus Melissa,” I moaned, as she began to squeeze me.

“Picture it, baby, picture all the girls,” she purred, her eyes gleaming as she glanced up again at the camera. And then, with her large smile pointed at its blinking red light, she slipped her hand though the tear Morgan had left, up the front of my pants. “There are going to be so many of us, your swarm of girls growing and growing and growing. Will you like that? Having that many more of us?”

“Oh g-god yes,” I admitted, already picturing a crushing throng of them and then gasping as I felt her palm and fingers slip below me, to cup my chicken-egg sized balls.

Feeling how swollen I was, she purred her approval. ”It’s good that he’s all nice and full now,” she said, massaging my sac gently and making my eyes cross, “all ready for a productive day.”

With her free hand she tore away, like tissue paper, the remaining portion of my scrub pants from my hips leaving me fully exposed and helpless to do anything about it. She took my shaft in hand and began speaking right to it, right to my cock. ”This weekend I got used to being with you every moment, baby,” she cooed, “And I started to miss you already.” One hand still played with my balls while the other slowly began to stroke me. She cooed and clucked down to it, treating my penis like it was directly her lover. “Now, I want to suck you until there’s nothing left inside.”

In an instant she had turned me in my chair, on her knees got between my legs, and reached up to - for some reason - adjust the position of the monitor and camera. 

“M-Melissa!” I exclaimed, trying to figure out what was happening. 

You wanted to frame the shot perfectly, so she could see you do this. I didn’t realize it right then but I do now. You wanted her to watch. And seethe.

“Shhh shh shh…I know we have work to do,” Melissa said, trying to control herself and keep the growl out of her voice as she continued to talk directly to my cock. “We have to make sure Gianna knows you’re a good worker, she has to know you can get to work on time, that you can finish your paperwork…” She took a moment to put her hair up into a loose bun. “But I also want her to see how good an Office Manager I am. How good I am at taking care of you….”

“Oh god…” I moaned, letting myself submit to the moment, feeling the eyes of both Melissa and Gianna on me as I collapsed.

“Good boy,” Melissa lauded, and suddenly I was in her mouth. Stars exploded in my vision, even as my eyes clamped shut. She had me fully in, down to the base, and the muscles of her throat vibrated around me. Girls, girls all around me, through these thin office walls, they all stood suddenly at attention. 

They knew what was happening. They could feel it. Could they…see me, too? 

I could picture them, all about the office, trying to keep from groaning or smiling too broadly, knowing what was coming. Melissa in the meantime purred and moaned, and barely had to move or caress my testicles at all because with just two deliberate passes up and down my length, her mouth had me exploding, my hips bucking up into her as she laughed with gurgling glee around my manhood.

“uuungh…unnngh…unnghh…” I mewled, just trying to stay focused, stay conscious as - yes - she seemed to be sucking everything I had right up out of me. She was draining me, unburdening me, granting me my morning relief. She let me come, come completely, come completely down into her throat until I was fully spent and flaccid. We both knew I’d need it again, but for now-

“How’s that?” she smiled, finally pulling herself back up and taking me again in her hands, so she could gently caress my softened length as she laid me back down again along my thigh. She wiped the corner of her lip with a finger, and swallowed demonstrably. “All better?”

I released one last shuddering breath, and let my head nod forwards. 

I passed out.

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thank you muchly to RiF for his help in editing

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