#Gastric ulcers

[ricisidro]

Misuse or irregular use of antibiotics could help create drug-resistant bacteria which makes it harder to eradicate #HelicobacterPylori bacteria in the stomach and small intestine that causes #gastriculcers and even #stomachcancer, published in the Lancet #Gastroenterology and #Hepatology journal.

To prevent H. pylori-related diseases, it is mportant to be mindful of personal hygiene, including frequent hand washing, the use of serving spoons during social gatherings for meals and maintaining a daily healthy lifestyle.

https://www.scmp.com/news/china/science/article/3255365/cancer-causing-stomach-bacteria-infecting-fewer-people-china-could-change#Echobox=1710646186-1

[hasansaad6413]

“Revitalize Your Digestive Health: Dr. Mofor’s Exclusive Home Remedy for Gastric Ulcers and Poor Digestion with Irish Potato”.

Are you tired of battling gastric ulcers and struggling with poor digestion? Join renowned medical professional Dr. Mofor as he unveils an exclusive home remedy in this enlightening video from Dr. Mofor Clinic. In this medium blog post, we delve into the secrets shared by Dr. Mofor, exploring the transformative power of the humble Irish potato in promoting optimal digestive health.

Dr. Mofor’s expertise shines through as he guides you through a comprehensive natural solution, promising relief from discomfort and a revitalized stomach. Bid farewell to gastric ulcers and welcome improved well-being as you embark on this journey with Dr. Mofor.

Don’t miss out on this opportunity to discover a holistic approach to digestive health. Hit play and empower yourself with Dr. Mofor’s valuable insights, ensuring a healthier and more comfortable future for your digestive system.

🎥Click the link below to watch the full video on YouTube. Like share comment tell us what you think: https://www.youtube.com/watch?v=bHdf4JTeA-A

Follow us on Website: https://drmoforclinic.com/

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Whatsapp: +(237) 6 98 77 31 10

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[f1inl3ey]

So I’ve got gastric ulcers and inflammation which is fun

[drforambhuta]

Gastric bleeding stems from a variety of factors, reflecting the complex nature of the gastrointestinal system. Key contributors include:

Peptic Ulcers: Erosions in the lining of the stomach or upper small intestine can emerge as a result of Helicobacter pylori infection, prolonged use of NSAIDs, or increased production of stomach acid.

Gastritis: Inflammation of the stomach lining might develop due to factors like infection, autoimmune disorders, excessive alcohol consumption, and extended use of medications like aspirin.

Esophagitis: Inflammation of the esophagus commonly results from gastroesophageal reflux disease (GERD), infections, or continual irritation caused by certain medications.

Diverticulosis and Diverticulitis: Pouches (diverticula) forming in the colon wall can become inflamed (diverticulitis), triggering instances of bleeding.

Inflammatory Bowel Disease (IBD): Conditions such as Crohn's disease and ulcerative colitis involve persistent inflammation of the digestive tract, which can lead to stomach ulcers and bleeding.

Tumors and Polyps: Both benign and malignant growths can initiate bleeding, either by directly eroding blood vessels or due to their tendency to cause gastric ulcers.

Vascular Abnormalities: Conditions like angiodysplasia (abnormal blood vessels) and esophageal varices (enlarged veins) can contribute to instances of bleeding.

Medications: NSAIDs, including aspirin, ibuprofen, and naproxen, increase the risk of gastric bleeding. Blood-thinning medications such as warfarin and clopidogrel also heighten the potential for bleeding.

Indraprastha Apollo Hospitals has some of the best hepatologists in Delhi to provide you with an accurate diagnosis and treatment plan based on your gastric condition.

[munaeem]

how does smoking affect the risk of developing a gastric or duodenal ulcer?

Smoking can significantly increase the risk of developing gastric or duodenal ulcers. The chemicals present in cigarette smoke, particularly nicotine, can weaken the protective lining of the stomach and duodenum, making them more susceptible to damage from stomach acid and digestive juices. Here’s how smoking can affect the risk of developing these ulcers: Increased acid production: Smoking…

[lupine-publishers-ctgh]

Lupine Publishers | Safety and Efficacy Assessment of PCNL in the Pediatric Population: A Single Centre Experience

Abstract

Introduction and Objective: Renal stone disease in children is on the rise with increased incidence and better modalities to diagnose the disease. Hence there is a necessity to strategize the evaluation and treatment of children with kidney stones. Our study was conducted to assess stone distribution, stone burden, and efficacy of PCNL in pediatric age group.

Methods: All paediatric patients with renal stone disease who subsequently underwent PCNL at our department from January 2017 to December 2020 were analysed.

Results: 84 patients ranging 1-18 years were analysed. Pain abdomen was the most common presenting symptom (61.9%) followed by fever (19.04%). The mean stone size was 2.16cm with equal side distribution. Most stones were located in the lower calyx (38%). The mean operative time was 65 minutes. Exposure to radiation from C arm ranged from 1.6-8.3 minutes. Complete stone clearance was achieved in 90.47% with a mean post- drop in Hb value to 0.72 gm/dl. Mean duration of nephrostomy tube in situ was 2.4 days and with a mean hospital stay of 3.8 days. Calcium oxalate was the most common type of stone (48%).

Conclusion: PCNL is safe and effective treatment for pediatric renal calculi with minimal morbidity and increased stone free rates irrespective of stone size. Proper patient selection, surgical skill and postoperative care contribute towards the success of the procedure.

Keywords:COVID-19; post-covid manifestations; long covid; gastrointestinal disorders; dysbiosis; dyspepsia; microbiome; probiotics

Introduction

The prevalence of renal stone disease in children ranges from 5 to 15%. Stone disease has a higher risk of recurrence in the pediatric age group making it crucial to identify the most effective method for complete stone removal to prevent recurrence from residual fragments. The optimal management of for pediatric stone disease is still evolving [1, 2]. Currently, ESWL is the procedure of choice for treating most upper urinary tract calculi in the pediatric population. However, a higher incidence of metabolic and anatomical abnormalities in pediatric patients has led to increased recurrence. Moreover, ESWL has relatively less efficacy for stones >1.5cm. Surgical intervention should be preferred in such cases so as to minimize the need for retreatment [3-5]. Percutaneous nephrolithotomy (PCNL) is less invasive than open surgery which can be a good candidate for complex and large burden stones [6]. Several studies over time with different power and limitations have reported safety and efficacy of PCNL leading to its consideration as the treatment of choice for children with stone larger than 15mm [7-9]. The advent of newer, finer instruments and increase in experience of endourological techniques such as tubeless PCNL, mini-perc, ultra-mini perc and micro-perc has resulted in reducing the morbidity rate among patients without affecting the outcomes in terms of clearance [10-14].

Therefore our study was conducted to assess the safety and efficacy of PCNL in the pediatric age group in terms of

a) Renal stone distribution & stone burden

b) The outcomes of PCNL including stone clearance, operative time, hospital stay, haemoglobin changes and

c) The associated complications of PCNL.

Materials and Methods

A prospective study was conducted at our hospital from January 2017 to December 2020 after obtaining institutional ethical committee clearance. All paediatric patients posted for PCNL at M.S. Ramaiah Medical College were considered in the study. The patients compatible for the study were interviewed and after obtaining informed and written consent they were enrolled in the study.

Inclusion Criteria:

All the patients below the age of 18 years undergoing PCNL.

Exclusion Criteria:

Anatomic abnormalities of the kidney (horseshoe kidney/malrotated kidney); Bleeding disorders; deranged renal function.

Patients were initially evaluated with a detailed medical history and a thorough clinical examination followed by a battery of investigations including CBC, RFT, Serum electrolytes, serum levels of calcium, phosphorus, alkaline phosphatase, uric acid, total protein, carbonate, albumin, parathyroid hormone (if there is hypercalcaemia), blood group & Rh typing , HbsAg, HIV, HCV, Urine: Routine & Microscopy, Urine: Culture & Sensitivity. For imaging –ultrasonography was used as a first study followed by spiral CT KUB if no stone was found. Intravenous pyelography was performed when a need arose to delineate the calyceal anatomy prior to percutaneous or open surgery. A sterile urine culture was confirmed before surgery. In patients with evidence of infection, antibiotics were given preoperatively to clear the infection prior to surgery. All patients received broad-spectrum antibiotics beginning 12h prior to the procedure and these were continued until 5 days postoperatively. All PCNL are performed under general anaesthesia. The patient initially placed in lithotomy position and a ureteric access catheter was placed under fluoroscopic guidance. The patient was then turned prone. After initial puncture, the tract was dilated using metallic or Teflon dilators. Paediatric PCNL was performed using adult instruments and clearance assessed intraoperatively by fluoroscopy. Ureteric stents and nephrostomy tubes were placed in most patients at the end of the procedure. Baseline patient characteristics, intraoperative and post-operative data were collected and analysed. Perioperative complications were classified using the modified Clavien Dindo system. In case of a supra-costal puncture, a chest X-ray was obtained subsequently in the post op period. An x ray of kidney ureter bladder was taken at 48 hours after PCNL. If needed a re-look procedure was done. The patient was followed up with an ultrasound & serum creatinine at 3 months, DMSA scan after 6 months to know the functional status of kidney & amount of renal scarring. Statistical analysis was performed using SPSS 22. Categorical variables were presented as number and percentage (%), whereas continuous variables were presented as mean ± standard deviation and median.

Results

84 patients ranging between 1-18 years of age were analysed with the mean age of study population of 11.04 years. Pain abdomen was the most common presenting symptom (61.9%) followed by fever (19.04%) with 4/84 having had prior surgical intervention for stone disease. The mean stone size was 2.16cm with equal side distribution. Most stones were located in the lower calyx (38%) followed by renal pelvis – 33%, middle calyx 17% and upper calyx 12% . The total operative time ranged from 30 minutes to 120 minutes with a mean of 65 minutes. Exposure to radiation from C arm ranged from 1.6-8.3 minutes. Intraoperative location of stone, puncture and after clearance are shown in figures 1a,1b,1c. Complete stone clearance was achieved in 90.47% with a mean post- drop in Hb value to 0.72 gm/dl. Mean duration of nephrostomy tube in situ was 2.4 days and with a mean hospital stay of 3.8 days. Intra-operative and post-operative complications in the study population are depicted. Calcium oxalate was the most common type of stone (48%).

Discussion

Although short wave lithotripsy (SWL) is considered the treatment of choice for symptomatic upper urinary tract calculi in children, but not a preferred option in patients with large stone burden, owing to higher rates of failure and residual stones. In such cases, PCNL with proven advantages can be safely advocated as a suitable treatment option in order to avoid numerous SWL sessions under anesthesia. Despite pediatric PCNL being described as early as 1985 by Woodside et al, [6] pediatric surgeons had their reservation in performing PCNL in children. This apprehension was due to the fear of parenchymal damage, early exposure to radiation and risk of major complications associated with the surgery. However, Dawaba et al, [9] proved the fear to be baseless by demonstrating that PCNL in paediatric population improved overall renal function without causing renal scarring. Similarly, Mor et al reported no significant scarring or loss of renal function in radionuclide renal scans [15-19]. He concluded that adult type tract dilation to 24Fr to 26Fr was not associated with significant renal function loss [19]. The size, number and site of tracts are not well defined in pediatric PCNL. While Gunes et al reported a higher complication rate in children <7 years operated with adult sized instruments [17]. Desai et al observed that intraoperative bleeding during PCNL in children is related to the size and number of tracts and suggested the need for technical modifications in children [20]. Although this calls for reduction in tract size, it may have an effect on the clearance rates.

In our study, 54(64.28%) underwent standard PCNL vs 30(35.71%) underwent Miniperc. We used amplatz sheath sizes in the range of 16F-28F. Size of tract dilatation was based on dilatation of pelvicalyceal system, the stone burden and no of punctures. Our clearance rates & transfusion rates were found to be similar in miniperc & standard PCNL. Our results are in concurrence with Bilen et al who reported that smaller tracts did not significantly affect stone-free rates but achieved lower transfusion rates [21]. They concluded that a 20Fr tract was as effective as working with adult sized devices and did not significantly increase the operative time [18]. Provided the quality of the puncture and subsequent tract is high, there is no greater morbidity than that reported from miniperc. Large tracts and instruments can facilitate more rapid and complete stone clearance.

Most of the stone burden was located in lower calyx (38%) in most of our cases with staghorn calculus noted in 4 patients. Single tract access was done in 72 patients with lower calyceal puncture being used mostly (43%) (Figure 2b). Multiple punctures were required in 12 cases (14.2%). We did not find any significant increase in complications following an upper calyceal puncture or with multiple punctures in our study which is comparable to Sedat Oner et al who concluded that an upper pole approach did not prolong operative time or add to the complications, making it a good alternative. A surgeon who has reached competence at performing PCNL should therefore not hesitate to use a superior caliceal approach in pediatric patients if deemed appropriate for stone removal [22-25].

Our length of hospital stay duration of nephrostomy tube in situ is comparable to previously published data. 42.85% of our cases were tubeless, which is safe when performing uncomplicated PCNL [26-34]. Prior renal surgery on the same side didn’t have any impact on outcome of PCNL [35]. Aldaqadossi et al have suggested that a previous open pyelolithotomy or nephrolithotomy does not affect the efficacy and morbidity of subsequent PCNL in pediatric patients [35]. We achieved a complete clearance rate of 90.47% which is similar to the published literature. Residual calculi noted in 8 cases were managed by ESWL. The complication rate during and after PCNL in paediatric patients varies widely in the literature. The difference in complication rates may be explained by the difference in stone burden location and experience of the surgical team. Our complication rate was 9.52% with fever being the most common. The lower incidence in complications could be attributed to the surgeon expertise at our centre.

Limitations

Our study population was from single referral center, which may not be generalizable considering small sample size. Another limitation is the lack of comparative groups such as ESWL/RIRS while evaluating the efficacy of PCNL.

Conclusion

PCNL is safe and effective treatment for pediatric renal calculi with minimal morbidity and increased stone free rates irrespective of stone size. Proper patient selection, surgical skill and postoperative care contribute towards the success of the procedure and reduces the complications.

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[corvus-frugilegus]

As a person who used to drink 8+ coffees a day and after several years developed a resulting severe GERD, I just know in my bones that Lucanis Dellamorte has incredibly bad acid reflux.

[astro-ellie]

travelling is so stressful i’m gonna die of a gastric upset before i even arrive at the airport

[amcrasto]

ZASTAPRAZAN

ZASTAPRAZAN 2133852-18-1 362.5 g/mol, C22H26N4O 1-Azetidinyl[8-[[(2,6-dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]methanone (ACI) azetidin-1-yl-[8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]methanone JAQBO; JP-1366; OCN-101; Zastaprazan citrate – Onconic Therapeutics, UNII-W9S9KZX5MD Originator Onconic Therapeutics Class…

[mothidocandart]

the way that my dad is having the worst time of all right now

[kaizenhospitals]

What are 3 symptoms of stomach cancer?

Stomach cancer can manifest through various symptoms, with three primary ones being abdominal pain, unexplained weight loss, and difficulty swallowing. Abdominal pain, often felt in the upper abdomen, can persist and present as pressure, aching, or sharp sensations. 

Unexplained weight loss, particularly a sudden drop in weight without changes in diet or exercise, can be a warning sign. Difficulty swallowing, known as dysphagia, may occur, especially if the tumor is located near the junction of the esophagus and stomach, making swallowing uncomfortable or painful. These symptoms, while associated with stomach cancer, can also indicate other health conditions, underscoring the importance of seeking medical advice for proper evaluation and diagnosis.

[drforambhuta]

The diagnosis of gastrointestinal conditions, such as gastritis, typically involves a comprehensive approach that combines medical history assessment, physical examinations, and a variety of tests. Here's an in-depth examination of the diagnostic process:

Medical History: Your healthcare provider will inquire about your symptoms, their duration, and any potential triggers or risk factors. These may include alcohol consumption, medication usage, or a family history of gastrointestinal issues.

Physical Examination: A physical assessment can reveal signs of gastritis, such as abdominal pain.

Endoscopy: This procedure entails the insertion of a slender, flexible tube equipped with a camera (endoscope) into the stomach to visually inspect the lining. It enables the identification of inflammation, ulcers, or any other irregularities.

Blood Tests: Blood examinations can detect specific markers, such as H. pylori antibodies or other indicators of inflammation, which aid in the diagnosis of gastritis.

Imaging Studies: In certain cases, imaging methods like X-rays or CT scans might be employed to evaluate the extent of stomach lining damage.

Once a diagnosis is established, the treatment approaches vary depending on the specific condition and its severity:

• Gastritis: Treatment for gastritis may encompass lifestyle adjustments, such as abstaining from alcohol and NSAIDs, coupled with medications to reduce stomach acid, manage symptoms, and address H. pylori infection if present.

• GERD: Managing GERD typically entails dietary modifications, lifestyle changes, and medications to control acid reflux.

• Peptic Ulcers: Treating peptic ulcers can involve antibiotics to eliminate H. pylori, medications to reduce stomach acid, and lifestyle alterations.

• IBS: The management of IBS focuses on symptom control, dietary adjustments, stress reduction, and occasionally, the use of medications to alleviate specific symptoms.

• IBD: In cases of Inflammatory Bowel Disease, medications are often required to manage inflammation and, in severe instances, surgical intervention may be necessary.

• Celiac Disease: The primary therapy for celiac disease involves adhering to a strict gluten-free diet. Avoiding gluten-containing foods can lead to symptom resolution and the healing of the intestinal lining.

You can undergo a quick and accurate diagnosis and get a customized treatment plan based on your gastric problems from Dr. Amit Maydeo, who is the best gastroenterologist in the country and is currently working at H N Reliance Hospital in Mumbai.

[munaeem]

what are the risk factors for developing a gastric or duodenal ulcer?

Gastric and duodenal ulcers can develop due to various risk factors, including: Helicobacter pylori infection: This bacterium is one of the most common causes of ulcers. It can weaken the protective lining of the stomach and duodenum, leading to ulcers. Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs): Frequent use of medications like aspirin, ibuprofen, and naproxen can irritate…