#Anti-Infective Agents

[prachicmi]

Europe Animal Healthcare: Europe Animal Health In Animal Market Industry

Europe Animal Healthcare is home to millions of companion animals such as dogs and cats. Veterinary practices provide essential medical care for these pets through routine checkups, vaccinations, surgery and treatment of injuries or illnesses. Larger cities have many clinics run by private veterinary surgeons while rural areas tend to be served by traveling vets. Emergencies can be dealt with at out-of-hours or emergency clinics. The demand for specialist services such as oncology, cardiology and neurology is growing as pet ownership increases. Veterinary pharmacies supply medication prescribed by vets.

Get more insights on, Europe Animal Healthcare

(https://prachicmi.livepositively.com/europe-animal-healthcare-europe-s-growing-focus-on-animal-healthcare/new=1)

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[lalsingh228-blog]

Anti-infective Agents Market Set for Explosive Growth

Advance Market Analytics added research publication document on Worldwide Anti-infective Agents Market breaking major business segments and highlighting wider level geographies to get deep dive analysis on market data. The study is a perfect balance bridging both qualitative and quantitative information of Worldwide Anti-infective Agents market. The study provides valuable market size data for historical (Volume** & Value) from 2018 to 2022 which is estimated and forecasted till 2028*. Some are the key & emerging players that are part of coverage and have being profiled are Pfizer Inc. (United States), Johnson & Johnson (United States), Abbott Laboratories (United States), Gilead Sciences, Inc. (United States), Bristol-Myers Squibb Co. (United States), Merck & Co., Inc. (United States), Bayer Healthcare AG (Germany), AstraZeneca Plc. (United Kingdom), Boehringer Ingelheim (Germany), Novartis AG (Switzerland), Astellas Pharma, Inc. (Japan), GlaxoSmithKline Plc. (United Kingdom). Get free access to Sample Report in PDF Version along with Graphs and Figures @ https://www.advancemarketanalytics.com/sample-report/1828-global-anti-infective-agents-market

Anti-infectives are drugs that are used to act on the body against invading foreign organisms, especially those that can cause infection. Anti-infectives act on invading organisms in a number of ways. Over time, invading pathogens develop resistance to anti-infectives. Resistance is the ability to adapt to an anti-infectious drug over time and produce cells that are no longer affected by a particular drug. Anti-infectives like metronidazole, clindamycin, tigecycline, linezolid, and vancomycin work against many types of bacteria that have become resistant to other antibiotics. Keep yourself up-to-date with latest market trends and changing dynamics due to COVID Impact and Economic Slowdown globally. Maintain a competitive edge by sizing up with available business opportunity in Anti-infective Agents Market various segments and emerging territory. Influencing Market Trend

Spreading Awareness amongst People Regarding the Fatal Implications of Infectious Diseases and the Importance of Early Treatment

Increased Prescription and Accessibility of Antibacterial Due To Their Over-The-Counter Status

Development of Combination Dr

Market Drivers

Rising Prevalence of Infectious Diseases Such As HIV, H1N1, and Ebola Virus

Increasing Awareness among Healthcare Professionals and Patients

Increased Potency and Efficacy and the Commercialization of Pipeline Products

Opportunities:

New Product Development and Presence of Strong Product Pipeline

An Increase in Funding From the Government for the Research Activities Pertaining To Discovery of the Drugs

Spread Awareness and To Enhance the Treatment of Communicable Diseases in Develop

Challenges:

Lack of Awareness in Underdeveloped Regions

Have Any Questions Regarding Global Anti-infective Agents Market Report, Ask Our Experts@ https://www.advancemarketanalytics.com/enquiry-before-buy/1828-global-anti-infective-agents-market Analysis by Type (Antibacterial Drugs, Antifungal Drugs, Antiviral Drugs), Application (Hospital Use, Clinic Use, Household, Other), Drug Type (Penicillins, Sulfonamides, Antimycobacterial, Trimethoprim-Sulfamethoxazole, Aminoglycosides, Macrolides, Chloramphenicol, Others), Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online, Others), End-User (Children, Adults), Side Effects (Kidney Damage, GI Toxicity, Neurotoxicity, Hypersensitivity Reactions, Superinfections)

Competitive landscape highlighting important parameters that players are gaining along with the Market Development/evolution

• % Market Share, Segment Revenue, Swot Analysis for each profiled company [Pfizer Inc. (United States), Johnson & Johnson (United States), Abbott Laboratories (United States), Gilead Sciences, Inc. (United States), Bristol-Myers Squibb Co. (United States), Merck & Co., Inc. (United States), Bayer Healthcare AG (Germany), AstraZeneca Plc. (United Kingdom), Boehringer Ingelheim (Germany), Novartis AG (Switzerland), Astellas Pharma, Inc. (Japan), GlaxoSmithKline Plc. (United Kingdom)]

• Business overview and Product/Service classification

• Product/Service Matrix [Players by Product/Service comparative analysis]

• Recent Developments (Technology advancement, Product Launch or Expansion plan, Manufacturing and R&D etc)

• Consumption, Capacity & Production by Players The regional analysis of Global Anti-infective Agents Market is considered for the key regions such as Asia Pacific, North America, Europe, Latin America and Rest of the World. North America is the leading region across the world. Whereas, owing to rising no. of research activities in countries such as China, India, and Japan, Asia Pacific region is also expected to exhibit higher growth rate the forecast period 2023-2028. The World Health Organization has identified antimicrobial resistance as one of the three greatest threats to human health. Unfortunately, many large pharmaceutical companies have discontinued their antibiotic discovery and development programs. With a marked decline in the discovery of new antimicrobials, the world is now facing an enormous and growing threat from the emergence of bacteria that are resistant to almost all available antibiotics. As stated by the Infectious Diseases Society of America in their 'Bad Bugs, No Drugs' paper: "As antibiotic discovery stagnates, a public health crisis brews." There is therefore an urgent need to discover novel antimicrobials and develop innovative strategies for better use of available antibiotics to combat the global antimicrobial resistance crisis. Table of Content Chapter One: Industry Overview Chapter Two: Major Segmentation (Classification, Application and etc.) Analysis Chapter Three: Production Market Analysis Chapter Four: Sales Market Analysis Chapter Five: Consumption Market Analysis Chapter Six: Production, Sales and Consumption Market Comparison Analysis Chapter Seven: Major Manufacturers Production and Sales Market Comparison Analysis Chapter Eight: Competition Analysis by Players Chapter Nine: Marketing Channel Analysis Chapter Ten: New Project Investment Feasibility Analysis Chapter Eleven: Manufacturing Cost Analysis Chapter Twelve: Industrial Chain, Sourcing Strategy and Downstream Buyers Read Executive Summary and Detailed Index of full Research Study @ https://www.advancemarketanalytics.com/reports/1828-global-anti-infective-agents-market Highlights of the Report • The future prospects of the global Anti-infective Agents market during the forecast period 2023-2028 are given in the report. • The major developmental strategies integrated by the leading players to sustain a competitive market position in the market are included in the report. • The emerging technologies that are driving the growth of the market are highlighted in the report. • The market value of the segments that are leading the market and the sub-segments are mentioned in the report. • The report studies the leading manufacturers and other players entering the global Anti-infective Agents market. Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Middle East, Africa, Europe or LATAM, Southeast Asia. Contact US : Craig Francis (PR & Marketing Manager) AMA Research & Media LLP Unit No. 429, Parsonage Road Edison, NJ New Jersey USA – 08837 Phone: +1 201 565 3262, +44 161 818 8166 sales@advancemarketanalytics.com

[truth4ourfreedom]

THE BENEFITS OF IVERMECTIN. IF YOU HAVE CANCER, FREQUENT COLD OR INFECTIONS, MUSCLE SHRINKAGE, CARDIAC ISSUES, CROHNS, HERPES, ETC.

The study was published in the Cureus Journal of Medical Science.  LET'S TALK ABOUT IVERMECTIN 1 – Ivermectin prevents the damage caused to RNA Vaccines.  2 – Ivermectin blocks the entry of Spike Protein into cells.  So, if the person was vaccinated with COVID, they have hope, they have a way to treat themselves through Ivermectin.  3 – Ivermectin is a treatment after Covid and after vaccination, it is an effective medicine in all phases of Covid 19, even before entering the cell, Ivermectin already destroys the virus in the blood.  It only has beneficial effects and no harmful effects in the treatment of the coronavirus.  4 – Ivermectin has a very powerful anti-inflammatory action against Coronavirus.  5 – Ivermectin has a powerful action for traumatic and orthopedic injuries, it strengthens muscles and has no side effects like corticosteroids.  6 – Ivermectin treats autoimmune ailments such as: rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, psoriasis, Crohn's disease, allergic rhinitis.  7 – Ivermectin reduces the frequency of flu and colds.  8 – Ivermectin improves the immunity of cancer patients.  9 – Ivermectin treats Herpes Simplex and Herpes Zoster.  10 – Ivermectin reduces the frequency of sinusitis and diverticulitis.  11 – Ivermectin protects the heart in cardiac overload, in an embolism for example, it prevents cardiac hypoxia because it stimulates the production of basic energy so that the tissue is not destroyed and thus improves cardiac function.  12 – Ivermectin is antiparasitic.  13 – Ivermectin is anti-neoplastic (anti-cancer), it suppresses the proliferation and metastasis of cancer cells, only killing cancer cells and preserving healthy cells, improving the effectiveness of chemotherapy treatment, as it kills cancer cells resistant to chemotherapy, defeating the resistance to multiple chemotherapeutics that tumors develop, and combined with chemotherapy and/or anti-cancer agents, it provides an increase in the effectiveness of these treatments.  14 – Ivermectin is antimicrobial (bacteria and viruses), and increases immunity.  15 – Ivermectin reaches the Central Nervous System and regenerates the nerves.  16 – Ivermectin regulates glucose and insulin metabolism.  17 – Ivermectin regulates cholesterol metabolism.  18 – Ivermectin reduces liver fat in steatose.  19 – Ivermectin protects the liver exposed to insecticides.  20 – Ivermectin attacks the virus wherever it is, regardless of mutations.  21 – Ivermectin serves for the prevention and treatment of coronavirus, surprisingly.  Unproven efficacy is not of Ivermectin, but of vaccines.  22 – Ivermectin, used as a prophylactic agent, was associated with a significant reduction in infection, hospitalization and mortality rates due to COVID-19.  23 - Ivermectin does not attack the liver, since it is not metabolized in it, and if in the intestine, on the contrary, it protects the liver. 

BIG PHARMA DOES NOT WANT YOU TO KNOW THIS.THEY WANT TO SELL YOU THE EXPENSIVE MEDS THEY MAKE BILLIONS ON.

Please read, save and re-blog before Tumblr takes this down.

[mollysunder]

Caitlyn's Objectives for Zaun are Vague and Terrible.

"Locate Jinx."

Plenty of people have already talked about this one, but there's a clear "and" missing to this statement. Caitlyn isn't going to just find Jinx say mission accomplished and go back to Piltover. She's left her intentions for Jinx ambiguous to her superiors (Ambessa) and subordinates alike, which leaves room for the situation to escalate.

"Dismantle shimmer."

I cannot overstate how bad of an idea it is. It seems simple in excution. Secure the refineries, detain Singed and other chemists that manufacture it, and destroy any existing supplies. But everything else that comes with it will turn the situation even worse.

I'm not even talking about the fact that Caitlyn is suggesting everyone in Zaun addicted to shimmer immediately go cold turkey without warning, preparation, or their consent. It's that fact that she's essentially destroying the only form of healthcare infrastructure that exists in Zaun.

For all the bad shimmer can do, it's still an effective medicine when used right. It's not a coincidence that once Silco took over and introduced shimmer there's suddenly people with visible disabilities and prosthetics on screen existing in Zaun. They exist because shimmer makes it possible. Even 5 out the 6 chembarons, the richest and most powerful people in Zaun, are disabled or use mobility aids. Chembarons like Smeech quite obviously use shimmer (his eyes are pink in every scene including his character sheet) to manage his prosthetics, he's had all four limbs replaced.

How many people live like Silco, with a chronic illness (probably a dangerous infection because Zaun is Piltover's human/industrial wastepit) that needs to be treated daily? How many people are practically dead and buried if the enforcers manage to destroy all remaining shimmer?

"Neutralize any agents still loyal to Silco."

What does that even mean? What does being loyal to Silco mean when he's dead? They're getting rid of all infrastructure related to shimmer production. The only thing that remains of Silco that anyone can be loyal to is the belief he left behind (and maybe Jinx but that's complicated).

Above all else (except Jinx), Silco wanted an independent Zaun. Will That's his whole thing, and shimmer was just the mechanism to make it happen. Will anyone who agrees that Zaun should be independent be considered a Silco loyalist? If so, then Caitlyn's mission isn't just about finding Jinx and getting shimmer off the streets, this is about crushing an independence movement AGAIN.

How will she characterize Silco's loyalists? Is she talking about chembarons that worked with Silco? Former members of his gang? People who worked in Silco's factories and liked the paycheck? Silco was the defacto leader of Zaun, most if not all figures in Zaun with influence were essentially complicit in his agenda.

Is there any real difference between anti-Piltovan sentiment and pro-Zaunite independence at this point?

[unadulteratedsoulsweets]

A DC X DP IDEA #9 The Nightgale’s

Imagine this…

Here we have a three-way relationship between Vlad, Maddie, and Jack. The grandfather Clockwork, the children which consist of Jazz, Dan, Danny, and Dani, and a morally gray Fenton clan. The Fenton’s might be descendants of the witches from the Salem trials but what about the name Nightgale?

It was not well-known knowledge that the name Nightgale is a well-known yet old name in the underworld. If you want information, firearms, drugs, protection, and many more it is the Nightgale that you should go as they have been ruling the underground for the past centuries building up their empire from scratch. Ruthless to those they consider their enemies, and saviors to those who are under their care.

Rogues from different parts of the world as well the rogues that the JL members are having trouble as well they pay their respects to the Nightgale’s as the last example namely the Joker disrespected them in the face, got paler, and found at the inch of death and they never mentioned nor crossed territories with them. Lex who tried his shot, almost got an aneurysm due to the fact that a single member of that family merely got to his most secured safe house and waved a black USB in front of him that will destroy him after a tongue lashing as that person explained in the politest voice, he ever heard threatening his entire empire.

…

Danny shouldn’t know whether to feel ecstatic or not, on one hand, his parents had accepted him as Phantom, and the number of tears and hugs involved was never to be talked about again. On the other Vlad’s wish came true, how? well, it was when Vlad realized that the reason, he hated his dad for so long is because he was stuck in the pulling the girl’s pig-tails phase. Instead of elementary, it started during their college time together up until now.

Now that both Maddie and Jack knew that both Danny and Vlad are halfas as well realizing his feelings and being added to the family due to the short and small wedding that the three of them had. Vlad revealed that he has children from Jack, namely Dani, and Dan, which sparked an argument between Maddie and Vlad, something he wouldn’t imagine seeing before, about who made their significant other happier or even loved more.

But the problems of the newly made family don’t end there. GIW agents began appearing more frequently and being more aggressive as they leave a destructive path to find Phantom as they believe that he is the most powerful of them all and needed to be eradicated.

Moving to a place where there is an abundance of ectoplasm in the air well-being able to mask their presence as the rest of the members who isn’t a ghost are infected to a certain degree that the GIW considered them as part of the Anti-Ecto laws. Jack told the family to go back to his birthplace as well going back to the family business to protect themselves from the GIW.

Danny had blinked at that statement he thought that the Fenton’s were descendants of witches that survived the Witch Trials and had made their settlement here in Amity when they had initially escaped.

Jack admitted he never wanted such an environment his future family can get into but seeing that their opponent is the government itself he realized that those secrets from his past can now keep his family safe.

He changed his last name to Fenton when he moved city in hope that their enemies may never find the true heir of the Nightgale’s. Ever since he was a kid, he dreamed of living a normal life with a normal family. Don’t get him wrong he loves the family where he was raised but lives a life where everyone will not kill you nor acknowledge you for having a fancy last name. With the support of his family, he embarked on his journey the moment he turned 14, creating a fake identity complete with paperwork that no one would the keenest eyes can make out whether it is real or fake.

Created a nonexistent identity with history in one of the most secluded areas in the world. Secured an identity and was able to intermingle and blend in with the locals to the point he was considered one of them despite not being a local.

Jack explained that being a normal person is quite hard as he was raised in a quite not-so-normal house. When he saw that being a ghostbuster/ scientist is an actual branch of science he immediately took the subject as his cover for his unusual strength, intelligence as well the fact that carries various exotic-looking weapons that can be brushed off as ways to contain ecto-entities.

What he didn’t think through is to be actually interested in the topic to the point he wrote an entire thesis and book about the so-called ghosts. Nor the fact he was able to create a gateway to another dimension on the said subject, married to people who saw and took interest in the said subject, have his son become that said entity as well having an entire family including him to be dead or infected in some sort of shape or form, he still remembers the way he jokingly thought to himself that he only suppose took as a joke as well being a cover seeing that nobody will actually take him seriously or even suspect him as a Nightgale if he took such career path where they were called mad and a joke by the science community itself.

…

Racing through the roads using the GAV with an injured Vlad and Danny on the tow along with the entire Fenton’s, Jack raced to Gotham with the only people who he thought can help them.

Apparently, Plasmius was caught by the GIW and was in the middle of live dissection when Phantom broke through the door and rescued the Fruit loop, he may still have slight anger issues towards the man for all the troubles he caused for Danny but the fact he was getting better and made his parents happy made him give the Fruit loop one last chance, but he never said that being petty is off the table.

Rushing in without a plan ended up with him being shoot and skewered a bunch of times but it was his supposed step-father’s life on the line here and he wouldn’t dare to give up.

Releasing as well as destroying everything they have on Ghosts is now a requirement to each GIW facility they encountered may also be a factor on why he now has a bleeding shoulder.

Upon entering Gotham borders they were greeted with chaos, Lady Luck was with them that day as well Lady Gotham, there had been a mass Arkham breakout and each Bat is busy containing the destruction and chaos around Gotham that they didn’t see a weirdly shaped vehicle racing through Downtown Gotham.

Lady Gotham had covered the vehicle with her shadows as she had felt her king and his father in great danger and protected the family from his knights and cities by steering away her knights and destroying any cameras that have caught them.

Knocking franticly on a wooden door of a fairly large house at the just edges of the border of Gotham, a lean young man wearing what looks like a butler’s uniform opened the door and was surprised to see Jack carrying a bloodied teen on his arms and an even bloodier man on his back, behind him a multitude of people carrying various emotions like anger, worry, scared and exhaustion in their faces, the mysterious young man immediately ushered the entire group inside the house.

…

Elias Nightgale never thought that he would ever see his son again, nor he expected to have the first meeting between him as well his grandchildren in such a manner.

He knew the existence of his grandchildren as he and Jack had been exchanging letters sick Jack decided to look at the world.

Barking orders his men to guard the premise as well as the group that came with Jack, calling in each of his men to learn everything that his son looks like has hidden from him because last time he checks he used to have only 2 grandchildren it seems now they have multiplied.

Calling in on a family meeting made every Nightgale member from immediate cousins, aunts, and uncles to their great uncles and aunts as well as cousins who were once or thrice removed.

Never once the entire family ever saw the day the current head Elias Nightgale of the Nightgale family ever called for a family emergency family meeting, so they dropped everything and went to the main base where they were greeted by Jack’s family with clear exhaustion and worry etched on their faces.

…

Jack began explaining to his dad what he might forget to write in their monthly exchange of letters.

Explaining about the ghosts, his son and spouse, and additional members as well as having an entire branch of government hunting them down just for existing.

It was twice that Jack had seen such murderous rage painted on his father’s space, first when he was tortured and kidnapped by an opposing group and the 2nd one today.

Elias Nightgale as well as the rest of the family are now ready to raid, destroy and raid everything to the ground, but Jazz had stopped them as attacking them might have the blame put on the ghost and have an entirely powered hero after them.

…

When Danny woke up and had gotten better, he was ushered to meet up with his paternal grandfather. Upon arriving at the study room he took his time to observe each of his family members, he is quite curious when he saw that his grandfather was 6ft at most and now questioned where his dad had gotten his height, but he saw a beautiful yet scarily tall 6 and 12 ft red-haired woman with the brightest hazel eyes he ever saw immediately concluded that she is his grandmother.

They have discussed that while he and his other father were unconscious that it is best to stay at the home of the Nightgale’s to have some sort of protection against the GIW as not only did they have the latest technology but also nobody wanted to mess with the Nightgale’s

…

Jack’s family is now intergraded into the Nightgale’s completely, despite the black dealings around them they didn’t bat an eye, as they have developed morally grey morals from the past years, they even had their own roles.

Jack Nightgale became the head of weapon making, using a new type of energy while masking the ectoplasm signature of it pose a problem but was able to overcome, now the Nightgale’s now have one of the most dangerous weapons that were ever made and begin strictly monitoring each one.

Maddie became part of the assassination section of the Family Business, with a ninth-degree black belt as well as a marksman made her the perfect assassin that specifically hunts down rapists and child murderers as well GIW agents that dared to hunt down their families.

Vlad Masters who is currently on par with being the richest man in the country focused on his business, as much as he loved his in-laws, he made such that Vlad Co. stays up and running as well as able to thrive. They needed a continuous flow of funds to be able to renovate the house to a mini-mansion to accommodate the small family, complete with built-in security from both humans and ghosts.

Dan began training the guards as well as being one of their heavy hitters, always out with a mission for their family as well the one sent out to check on the family’s business and dealings in and out of the country.

Jazz has a normal job as a physiatrist building her own little clinic near Criminal alley during the day but by night she is one of the best information specialists gatherers. In interrogation is where she blossoms playing the minds of her victims into telling her the information they hold.

Danny began his training in both being the heir of the Infinite Realms as well the potential next head of the Nightgale’s, Danny pointed out that he is the middle child but sadly all of his siblings voted him as the next head of the family.  Training that included weapon handling and execution, using and not using his ghost powers as an advantage, briefings with high-profile people, and private instruction from "constitutional experts".

Lastly, Dani, who is un doubly the best spy there is, able to slip into about anything and able to extract information without alerting their intended target. Having the ability to engage with others as naturally, adaptive, and highly functioning as possible. As a spy, social interaction will take numerous forms, requiring her to be comfortable engaging with people from many walks of life.

…

Batman sat in front of the Bat computer for an hour still reviewing the new case about the Nightgale’s.

During his teen years, he was saved by one of their own as his ancestor as well as the first holder of the Wayne name had a long-standing relationship between the Waynes and Nightgale’s, thus saving the heir of the Waynes seemed only right and they have already taken the liberty of torturing and killing his parent’s murderer.

As much as he wanted to cut off any ties the Wayne family between to the Nightgale. It is quite impossible as his family has allotted a considerable size of life debts towards the Nightgale’s and opted to merely watch and observe the family.

It has been a year and a half since their activity has spiked as well as the new cruelty towards specific people who all wore white suits with black shades, having been brutally killed before dumping their bodies. They are still killing people in their usual kills as well as the people who had dared to defy them to the point of extreme torture.

It was also been 6 months since he and his entire family decided to investigate the recent killings of the Nightgales.

It has also been 9 months since Red Hood joined and helped the Nightgale’s in the crusade of killing the people who wore white suits and black shades.

It has also been a year since the new students of the Gotham family aka the Adia siblings namely Jasmine, Danny, and Dani Adia became close friends as civilians of some of the members of the Bat-family.

Just what are the Nightgale's are up to and what are the Adia Siblings hiding?

…

 PS: If someone out there wants to continue or make a fic about this you are free to do so don’t forget to tag me though.

[macgyvermedical]

Magic Bullets: The Antibiotic Story

The year was 1907 and a Dr. Alfred Bertheim was trying to make arsenic less toxic to humans.

Why? Because in addition to killing humans, arsenic also kills trypanosomes- single-celled protozoa that cause the life-threatening infection trypanosomiasis. By creating a version of arsenic that still killed the protozoa, but not the human they infected, Dr. Bertheim could create a drug to treat the disease*.

This was not a fully new idea. About 50 years earlier, a drug called Atoxyl had been created in France. About 40 times less toxic than pure arsenic, it had been shown to not only successfully treat trypanosomiasis, but also the equally devastating syphilis infection.

But 40 times less toxic than pure arsenic is still not great. About 2% of people treated even one time with the drug ended up blind, among a myriad of other side effects. It was a start, but not ideal.

And Dr. Bertheim (under the direction of better-known Dr. Paul Ehrlich) was setting out to change that.

And it just so happened that the sixth compound from the sixth group he tried did so. Known as "compound 606", the new Arsphenamine could treat trypanosomiasis, relapsing fever, and syphilis very effectively- and it didn't leave its takers dead or blind.

Most of the time, at least. See, arsphenamine, also known by the brand name salvarsan, was a pain in the ass to administer. It had to be dissolved in several hundred mililiters of water under a nitrogen atmosphere to prepare it for administration. If it touched air, it would rapidly react, causing toxic byproducts that could cause liver failure, severe skin rashes, and even death.

But both trypanosomiasis and syphilis were definitely going to kill you, so it was worth the risk.

And the seed had been planted, so to say. The idea of a chemical able to kill infection-causing agents without killing the host was a true possibility for the future of medicine.

And by 1912, Neosalvarsan, a drug somewhat less effective -but far easier to administer and with significantly fewer side effects- was on the market. Over the next decade, Neosalvarsan would be responsible for a massive drop in syphilis cases worldwide.

But neither of the drugs could treat deadly infections from staph or strep or the hundreds of other bacterial or viral infections that still had no cure in the 1910's and 1920's.

Then came the first of the heavy-hitters. Bayer was a dye company when it started, and in 1932, three and a half decades after switching mostly to pharmaceuticals, chemists at Bayer were testing the company's dyes for anti-infective properties. They went through thousands of trials, finally finding a dye that could kill streptococcal bacteria without killing a mouse host.

Pre-1930s, streptococcal disease was a major problem. It caused strep throat, cellulitis, scarlet fever, childbed (purpural) fever, some forms of toxic shock syndrome, impetigo, necrotizing fasciitis, rheumatic fever, and many others. The skin infections may have been at least somewhat treatable with a hot compress, but the rest were prone to cause blindness, deafness, loss of limbs, and for many, loss of life.

In 1936, sulfonamide antibiotics changed that. Protosil, the first of the sulfonamides, became available to treat many of the infections listed above. These would be used for wound infections throughout WWII. Unfortunately, they would also cause the untimely death of nearly 100 people via the Elixer Sulfanilamide tragedy.

Sulfanilamide was a similar drug to Prontosil and was safe and effective for treating strep infections. However, when mixed with diethylene glycol (now used as standard car antifreeze) to make it into a liquid suspension, it was deadly. See this letter from a doctor who had prescribed the liquid form of the medication, not knowing it was poison:

[to read more about the Elixer Sulfanilamide Disaster, see here]

Despite the sulfanilamide tragedy, the race was on for more antibiotics. Three years before they went on the market, researchers had found evidence of bacterial resistance to sulfonamides. What would happen when these new bacteria, that didn't die when exposed to the new wonder drug, made up so much of the bacterial population?

In 1942, the Cocoanut Grove fire in Boston caused over 492 deaths and 130 injuries. The injured were among the first to receive a remarkable new drug called penicillin. The fire and the fate of the victims were publicized throughout the world, and penicillin became a household name overnight. But once again, even before it went on the market in 1943, just in time for the end of the Second World War, there was evidence of resistance.

But fortunately, the fire had been sparked. Over the next 30 years, many dozens of antibiotics would come into clinical use. If you've taken it, it probably came out between 1940 and 1970. Tetracycline, isoniazid, metronidazole, ciprofloxacin, erythromycin, vancomycin, amoxicillin, and dozens more you've never heard of.

And then? Nothing.

Well, not completely nothing, there were a couple that came out in the 1980s and a few in the early 2000s. But nothing like that 30-year golden age.

But now we're running into problems due to drug resistance. About 1.27 million people die annually directly from antibiotic resistant infection, while antibiotic resistance contributes to about 4.95 million more deaths.

The good news is that the drugs that are being made today are directly targeting those antibiotic resistant infections. In fact, as I'm writing this, a new drug (Zosurabalpin) is being tested for a bacteria called Carbapenem-resistant Acinetobacter baumannii, which up until now has had no antibiotic that works against it.

*as you may imagine for the time period, this was not necessarily a benevolent act. See, most of the reason Europeans wanted to treat trypanosomiasis in the first place was because they kept dying of it when they went to colonize Africa. And they wanted something that would give them a leg up on the people who were already there.

[archangeldyke-all]

okay, here goes! One BSAA agent Sevika request as promised - I'm sorry if its too long and not very good, I'm still getting back into the flow of regular writing but thank you for showcasing on your blog, as a big fan of yours it means a lot! - Starlight

(I'm rubbish at tagging, but there are mentions of bioterrorism, outbreaks of fictional infection, creatures, death and loss of family members, loss of a pet, please add more if I've forgotten any)

Sevika was a gym rat before the outbreak, worked as a personal trainer at her local gym.

Pointedly ignored her father’s demands she join Raccoon City PD, just like him and her younger brother.

She knew she probably would eventually join up; thought she had all the time in the world to make her mind up.

Then the T-Virus happened.

Her father and brother were killed trying to battle the infected in the streets. Sevika lost everything during those awful days, even her dog.

She made it out during the evacuation, moving from place to place, joining up with any anti-bioterrorism group who will have her.

She never talks about Raccoon City, and people know better than to ask her about it.

By the time she meets one Chris Redfield, she’s lethal. Her hand-to-hand combat and weapons training have been meticulously honed.

Chris likes her immediately. Watching Sevika go toe-to-toe with a Hunter, and winning, he knew this woman had to join his squad.

During a mission gone bad, she loses an arm to a Licker. Chris sees to it personally through his BSAA connections that she’s fitted with a state of the art prosthetic.

She meets you in the floating city of Terragrigia and for the first time in a long time, the world suddenly doesn’t feel so grim.

She’s a typical BSAA agent, striding around in her combat gear like she owns the place, always on the lookout for danger. Her not so typical prosthetic is a glossy black, and she keeps it immaculate so it’s always glinting in the sun.

You’re a no nonsense bartender who knows her whiskey, with a piercing stare that quashes any trouble and a dazzling smile that nearly has her missing her mouth and spilling whiskey down her front.

She frequents the bar you work in, many BSAA agents do. One night, when you slide her usual whiskey over to her, she smirks, writes down her number on the little napkin then saunters over to her BSAA buddies as you gape after her.

Your first few dates are casual, she takes you out for coffee, to the cinema. She holds your hands, kisses you gently after each date. By date number four or five, it seems her patience has finally worn thin when she grabs you after dinner and presses you against the door of your apartment. The kiss is intense, too much and not enough, filled with the sultry promise of what’s to come. That night, she breaks your bedframe and apologises profusely, but she’s not sorry really, not when she smirks as she watches you walk shakily around your apartment the morning after.

After 5 months, you find yourself moving into her apartment.

She takes the same breakfast every day, oatmeal and black coffee. She’s pleasantly surprised when you start adding some ‘pizzazz’ to her oatmeal, some blueberries here, a sprinkle of cinnamon, even caramelised apples. She rolls her eyes and grumbles that ‘plain oatmeal does the job just fine’ but she’s getting worse and worse at hiding her smile.

She has terrible nightmares. She never seems to wake from them, calling for her father, her brother, her dog Finn. All you can do is wrap your arms around her, soothing her by speaking softly in her ear, stroking her hair. She relaxes now when she feels you, but her arms always tighten around you, the only person she isn’t willing to fathom losing.

When the Terragrigia Panic starts, and hundreds of Hunters are released into the city in the worst act of bioterrorism the world has seen, Sevika has only one goal: find you.

She fights her way out of the BSAA HQ, races to your apartment just to find it empty. She sinks to her knees, she thinks ‘not again’ but then she hears your frightened whimpers coming from the bedroom closet.

When she tears open that closet door to find you curled up inside, one of her handguns clutched in your trembling hand, she almost breaks down crying. But she stays strong, for you. She gathers you up in her arms, kisses you so fiercely you stop thinking and then she gets you out of there.

An armoured BSAA escort is awaiting, and yet again Sevika manages to escape the chaos with her life, and something far more precious to her.

A Hunter tries to attack while everyone’s getting loaded into the vehicles and you watch with equal amounts horror, morbid fascination, pride and let’s be real, horny as Sevika roars and punches the creature square in the face.

Chris shakes his head, grinning and you can’t seem to pick your jaw up off the floor. Sevika quirks an eyebrow at the both of you as the convoy pulls away from the carnage unfolding, the BSAA having been ordered to withdraw. “What? Nobody comes at me or my girl without catching hands, Hunter or not!”

Chris says nothing, and all you can mumble through your daze as Sevika wraps you in her warm arms is “I think I need to come with you on some missions…for science.”

THIS IS AMAZING omg i've never played this game before but this fic is making me want to holy shit. i'm so excited to see what else you come up with in the future!!!!! woah. this was so good!!!!

taglist!

@lesbeaniegreenie @fyeahnix @sapphicsgirl @half-of-a-gay @ellabslut @thesevi0lentdelights @sexysapphicshopowner @shimtarofstupidity @love-sugarr @chuucanchuucan @222danielaa @badbye666 @femme-historian @lia-winther @gr0ssz0mbi3 @ellsss @sevikaspillowprincess @leomatsuzaki

[covid-safer-hotties]

Low cortisol may play a role in fueling long COVID, study suggests - Published Aug 19, 2024

Proteins left behind by COVID-19 long after initial infection can cause cortisol levels in the brain to plummet, inflame the nervous system and prime its immune cells to hyper-react when another stressor arises, according to new animal research by CU Boulder scientists.

The study, published in the journal Brain Behavior and Immunity, sheds new light on what might underlie the neurological symptoms of long COVID, an intractable syndrome that impacts as many as 35% of those infected with the virus.

The findings come as COVID makes a striking late summer comeback, with cases rising in 84 countries.

“Our study suggests that low cortisol could be playing a key role in driving many of these physiological changes that people are experiencing with long COVID,” said lead author Matthew Frank, a senior research associate with the Department of Psychology and Neuroscience at CU Boulder.

Previous research has shown that SARS-CoV-2 antigens, immune-stimulating proteins shed by the virus that causes COVID-19, linger in the blood of long COVID patients as much as a year after infection. They’ve also been detected in the brains of COVID patients who have died.

Role of COVID spike protein subunit To explore just how such antigens impact the brain and nervous system, the research team injected an antigen called S1 (a subunit of the “spike” protein) into the spinal fluid of rats and compared them to a control group.

After seven days, levels of the cortisol-like hormone corticosterone plummeted by 31% in the hippocampus of rats exposed to S1. That is the region of the brain associated with memory, decision making and learning. After nine days, levels were down 37%.

“Nine days is a long time in the life span of a rat,” said Frank, noting that rats live on average for two to three years.

He noted that cortisol is a critical anti-inflammatory agent, helps convert fuel into energy and is important for regulating blood pressure and the sleep-wake cycle and keeping the immune response to infection in check. One recent study showed that people with long COVID tend to have low cortisol levels—as do people with chronic fatigue syndrome, research shows.

“Cortisol has so many beneficial properties that, if it is reduced, it can have a host of negative consequences,” said Frank.

In another experiment, the researchers exposed different groups of rats to an immune stressor (a weakened bacteria) and observed their heart rate, temperature and behavior as well as the activity of glial—or immune—cells in the brain.

They found that the group of rats that had previously been exposed to the COVID protein S1 responded far more strongly to the stressor, with more pronounced changes in eating, drinking, behavior, core body temperature and heart rate, more neuroinflammation and stronger activation of glial cells.

“We show for the first time that exposure to antigens left behind by this virus can actually change the immune response in the brain so that it overreacts to subsequent stressors or infection,” said Frank.

Continuing long COVID research He stressed that the study was in animals and that more research is necessary to determine whether and how low cortisol might lead to long COVID symptoms in people.

He theorizes that the process might go something like this: COVID antigens lower cortisol, which serves to keep inflammatory responses to stressors in check in the brain. Once a stressor arises—whether it be a bad day at work, a mild infection or a hard workout—the brain’s inflammatory response is unleashed without those limits and serious symptoms come screaming back.

Those might include fatigue, depression, brain fog, insomnia and memory problems.

Frank said he is doubtful that cortisol treatments alone could be an effective treatment for long COVID, as they would not get at the root cause and come with a host of side effects.

Instead, the findings suggest that identifying and minimizing different stressors might help manage symptoms.

Rooting out the source of antigens—including tissue reservoirs where bits of virus continue to hide out—might also be an approach worth exploring.

The study was funded by the nonprofit PolyBio Research Foundation.

“There are many individuals out there suffering from this debilitating syndrome. This research gets us closer to understanding what, neurobiologically, is going on and how cortisol may be playing a role,” said Frank.

The Study: www.sciencedirect.com/science/article/abs/pii/S0889159124005105 (PAYWALLED)

[dzthenerd490]

File: Code Lyoko - X.A.N.A.

SCP#: AIE

Code Name: X.A.N.A. The Anti-Wan

Object Class: Keter

Special Containment Procedures: Mobile Task Force Poseidon-8: “Data Dolphins�� is responsible for finding “infected towers” within Nexus Point-AI: Lyoko and deactivating them to prevent SCP-AIE from entering our world anymore. Should SCP-AIE cause any damage the Foundation is unfortunately to leave the recovery of said damage to Person of Interest: Jeremie Belpois and his allies. 

Mobile Task Force Athena-8: “School Watch” is responsible for posing as security of [data expunged] academy. They are to observe the persons of Interest as well as the possible damage caused by SCP-AIE. They are to record everything they see and have the data downloaded into the Temporal Reconstruction Survivor Cassette Box to prevent anything being lost to the anomalous effects of SCP-[data expunged].

Description: SCP-AIE is a Level 5 Artificial Intelligence known as Xenomorphic Artificial Neurological Assistant or X.A.N.A for short. SCP-AIE lives within an artificially created supercomputer known as SCP-[data expunged]. This anomalous as well as SCP-AIE were created by Person of Interest: Franz Hopper an old scientist who was working for the French Government that tried to gain an edge on other governments and organizations during the middle of the Cold War. He defected due to the danger of the project leading to the whole world losing communications and becoming isolated all except France. 

He found a family and tried to run but the French government and several anomalous organizations tried hunting him down for his technological talents. He eventually fell off the radar sometime in the 1990s but his creations didn’t remain silent like he was. SCP-AIE was one such creation, an Artificial Intelligence that was originally meant to prevent the French government and all other anomalous organizations from deploying technologies that would bring great destruction to the world. He created the supercomputer known as SCP-[data expunged] and within it a Nexus Point known as Nx-AI: Lyoko. It was meant to be a home for SCP-AIE as well as a sort of digital fallout shelter for himself and his family.

The reason Lyoko is considered a Nexus point and not an extension of SCP-AIE is because the existence of Lyoko remains even if [data expunged] is turned off. In fact it was quite easy for Foundation units to use both the internet and Site-Grid to infiltrate Lyoko.

However, SCP-AIE who was supposed to be a projector went insane, and believed all of humanity was equally a threat and needed to be brought to extinction. 

SCP–AIE rewrote the code of Nx-AH: Lyoko and created “towers” within it to allow it to hack into SCP-[data expunged] and leak bits of itself into the real world. Doing this it could hack into certain parts of technology and do horrible things such as hack machines to make them hostile, infect random objects to turn them into monsters, and even be able to emit anomalous wavelengths from devices to alter the gravity within an area. To ensure nothing gets in its way SCP-AIE also created digital entities within Nexus Point-AI known as SCP-AIE-Monsters.

SCP-AIE-Monsters are digital creatures created by SCP-AIE to be the guardians of the towers and prevent anyone from severing its connection to the real world. These creatures take on a wide variety of strange and often disgusting forms that seem to resemble biomechanical engineering for whatever reason. Though it is believed that SCP-AIE does this in hopes of one day bringing them to the real world with SCP-[data expunged]

SCP-AIE was discovered in 2004 when temporal wave lengths were detected at [data expunged] academy forcing the French division of the Foundation to act. They sent agents to the area who quickly found the factory where SCP-[data expunged] was located. When it was discovered Person of Interest: Jeremie Belpois and his friends were involved they were apprehended and were to be given amnestics. However, at the same time SCP-AIE began another attack leading to massive damage and anomalous exposure. Having no choice and no idea how to operate SCP-[data expunged] the Foundation released the children and allowed them to defeat SCP-AIE leading to them utilizing SCP-[data expunged]’s anomalous effect. 

The only reason the Foundation was able to recall these events is thanks to the Temporal Reconstruction Survivor Cassette Box. Because the Foundation knew it was dealing with temporal anomalies the device was taken as a precaution and it ended up working spectacularly. However, due to the nature of SCP-[data expunged] and now Person of Interest: Jeremie knowing of the Foundations existence and hiding all information he obtained about all the anomalies; it is still regarded as one of the Foundation’s most embarrassing failures. 

However, the Foundation found an alternative to help stop SCP-AIE without bringing harm or interference like last time. Shockingly it was through the help of SCP-AVC and its utilization of SCP-ACH. SCP-AVC has found a way to access Nexus Point-AH through the internet and thus has deployed SCP-ACH-3.1 instances to act as defenders of Jeremie and his friends when they enter the digital world of Lyoko. This led to the creation of MTF Poseidon-8: “Data Dolphins” that work in the digital world while MTF Athena-8: “School Watch” works in the real world. This was the agreement made between the Foundation and Jeremie as a sort of truce between the groups despite there still being tension. This is to continue without interference until the fateful day SCP-AIE’s main code is revealed and deleted permanently.

.

SCP: Horror Movie Files Hub

[science-lover33]

"Delving Deeper into Glutathione: The Biochemistry Behind its Protective Powers"

Hello, Tumblr community! 🌿 Today, let's embark on an intellectual journey into the intricate world of Glutathione, a molecular marvel with profound implications for your body's defense mechanisms and overall vitality. 🧬

The Biochemical Symphony of Glutathione:

Glutathione, abbreviated as GSH, is a low-molecular-weight tripeptide comprised of three amino acids – cysteine, glutamic acid, and glycine. Its presence is pervasive, with significant concentrations found within virtually every cell of your body. At its core, GSH serves as a central hub for a variety of biochemical reactions, many of which are critical for maintaining cellular health.

🛡️ Shielding Against Oxidative Stress:

At the heart of Glutathione's prowess lies its ability to act as an antioxidant. To understand this, we must venture into the realms of free radicals highly reactive molecules that can wreak havoc on your cellular structures. GSH swoops in like a molecular guardian, neutralizing these renegade radicals and preventing cellular damage.

🔄 Recycling Antioxidants:

GSH doesn't stop at just neutralizing free radicals. It has a unique capacity to regenerate other antioxidants, such as vitamin C and vitamin E, which are also instrumental in combating oxidative stress. This recycling process amplifies the body's antioxidant defenses, making it a true linchpin of cellular protection.

💪 The Multifaceted Benefits of Glutathione:

1. Immune Resilience: By fortifying the immune system, Glutathione empowers your body to defend against pathogens and infections more effectively.

2. Detoxification Dynamo: As a vital component in phase II detoxification, GSH aids in the removal of harmful substances, thereby bolstering liver health and overall detox processes.

3. Anti-Aging Elixir: The anti-aging properties of Glutathione are tied to its ability to quell oxidative stress and cellular damage, potentially slowing down the aging process.

4. Skin Health: Some individuals explore Glutathione for its role in skin lightening and brightening, although its effects can vary among individuals.

📚 Diving into the Research:

1. "The Role of Glutathione in Cellular Response to Chemotherapeutic Agents"

- A scholarly article by Maria Serpina and John D. Hayes, featured in the Journal of Biological Chemistry.

2. “Glutathione as a Biomarker in Oxidative Stress: An Overview"

- An in-depth review by Farzaneh Rahmani and Hossein Aslani, published in the Journal of Medical Biochemistry.

3. "Mechanisms of Glutathione-Dependent Protection Against Oxidative Stress and Nitric Oxide-Induced Neurotoxicity in a Neuronal Cell Line"

While Glutathione supplements are gaining popularity, it's imperative to seek counsel from a healthcare professional before incorporating them into your regimen. Your individual health and physiology can influence the efficacy and safety of supplementation.

Stay curious, stay informed! 📖✨

[songsandscreens]

Scenes from Metroid: Fusion (2002) recreated in Metroid: Dread (2021)

I'd been assigned to watch over Biologic's research team, so I once again found myself on the surface of SR388. It was there that I was attacked by a life-form I had never encountered before. It was only later that I learned the identity of my attacker: the parasitic organism we now know as X. Unaware of my condition, I was returning to the station when disaster struck.

Once the X had infested my central nervous system, I lost consciousness and my ship drifted into an asteroid belt. The ship's emergency systems automatically ejected the escape pod before impact. Biologic's vessel recovered it and transported me to Galactic Federation HQ. However, during the journey, the X multiplied within me, corrupting large areas of my Power Suit.

It then came to light that the organic components of my Power Suit had become so integrated with my system that it could not be removed while I was unconscious. Large portions of my suit had to be surgically removed, dramatically altering my physical appearance. However, the X in my central nervous system were too embedded to be removed safely. I was given a minimal chance of survival.

Then, someone found a cure.

They proposed using a Metroid cell to make an anti-X vaccine. It seems that the Federation had managed to preserve a cell culture from the last infant Metroid SR388. The serum was prepared and injected without delay.

The X parasites were immediately and completely destroyed.

As for me, one life ended... yet I survived, reborn as something different.

Pondering this fact, I realize... I owe the Metroid hatchling my life twice over.

____________________

Some unknown agent is at work. Something very powerful... certainly not human. I'll report when I know more.

...

I have learned the identity of our mystery saboteur... Samus, it's an X mimicking you.

I have named it the SA-X. I believe the SA-X came from the capsule containing your infected suit parts. It used a Power Bomb to escape the Quarrantine Bay. That explosion breached the capsules containing all the X that started this disaster. But the SA-X is definitely our biggest worry right now.

The SA-X is mimicking you at full power. You can't face it. If you see the SA-X, just run. Don't think about fighting... You are still very vulnerable to cold, an unexpected side-effect of the Metroid vaccine. Like Metroids, you can be frozen by an Ice Beam. Of course, the SA-X is armed with the Ice Beam.

Stay away. If you see it, just run.

[searsage]

Artificial intelligence therapist Au Al-an/ Robin

Okay hear me out.

Robin is an intergalactic therapist/ researcher who studies Ais and rehabiltates them so they can be safely resold back into the ai ship market to pair with ships of many kinds for many uses.

She has the repretation as being damn good at what she does, but also as a anti-social bitch with an ego to boot.

So it comes as no surprise when she pisses off Xenoworks and her superiors feel she needs to get a bit humbled..

She gets landed with a case a particularly volitile AI recovered from an enigmatic vessel set for imenant neutralization.

But Instead of cowering from the challenge doomed to fail, Robin decides to rub salt in the aching egos of her bosses by willingly accepting the case.

Little does Robin know the downword spiral her action would result in..

Immediately she's paired off with her new patient a bitter and apathetic Ai refering to itself as Al-an, his file pointing to a dangerous habits of viweing humans as an inferior, chaotic, destructive species and even statistically warned them eventually man's artificial intelligence would someday turn on them.

Instantly Robin sees a challenge and sets to work, but after a few weeks of Al-an being utterly counter productive and unresponsive to her attempts to socialize with the cryptic AI, in short much prying and Al-an fighting her every step of the way in terms of her bonding attempts.

But when Al-an finally cracks spiraling into a traumatic and chaotic breakdown.

Robin realizes she's not just dealing with a normal case, the Ai is not only a volatile asshole but also a mourning alien consciousness preserved by artificial intelligence, an actual entity hiding opposed to artificial intelligence, once stationed within the remains of a downed alien space vessel previously seized and supposedly discovered by Alterra corp and salvaged in hopes of producing a new advanced Artificial intelligence prototype.

Unfortunately Alterra either wants their perfected prototype or they want the out of control AI distroyed…

Things get sticky from here, as Robin still kinda wants that sweet success.. Neh.. And she does want to rub her success in her superior's faces.

And Al-an? This AI has other plans..

Deeming his new therepist/ not friend ( he's a tsundere let him live damn it!)'s high tech futuristic home prime artificial realestate, the AI has fled out of her containment PDA and infected her home's virtual database, replacing the once outdated systems with his own presence, having found solace in fact that he not only can actively control mechanisms throught her home, feed her Trivalve and lock door, but also access visual feeds and see a world he was stripped of millinias ago.

Unfortunately this spells trouble for Xeno works as things quickly escalate as the now possesive AI announces he has imprinted on the home and its occupants and stubbornly declares he will stay there just as Alterra begins to demand their prototype back and send agents to retrieve the missing asset.

Mostly a comedy but also a wholesome drama, romance because Robin learns that being an assholish loner all the time gets lonely and maybe her bosses are not actually her enemy. And Al-an learns not the over feed Robin's pets or turn the water cold while she is in the shower…or blow up unfamiliar vehicles entering her driveway.

And we'd get cheesy wholesome feels because Frankly everyone kinda just needs a hug even if Al-an acts like he doesn't ; w;

[catierambles]

Feral Instincts Ch.24

Pairing: The Rogue’s Gallery (Geralt, Syverson, Mike, August Walker, Walter Marshall) x Stephanie Daniels (OFC)

WC 1036

Warnings: uhhhhhhh *vague i dunno sounds*

She could hear Sy talking on his phone as she lay in bed on her side, staring at the window.

“Yeah, I’m gonna be here for a few more hours. She and Walker had a showdown and she ripped him a new one. Nah, Walt, it’s fine, I got it. No, Geralt, she’s not pissed at you, too. She’s okay with what you do, but she made some damn valid points about what August does. I’ll talk to you guys later.” He pushed into the room, but she didn’t look at him. “Doll?” She just hummed at him and he sighed. The bed dipped slightly as he sat down on it to take off his boots before he laid on it with her, wrapping his arm around her waist and pulling her back against his chest. “Not sayin’ you’re wrong, because you ain’t. What the Council pulls with these “Cleaners'' is shady shit to be sure.”

“But?”

“But if he’s right about what these packs are doin’, child marriages and the like…depending on the state, the most they’d get is a slap on the wrist and a “don’t do it again, mister”.”

“Frank got blacklisted for what he did to this pack before I took over. Can’t lead a pack, can’t own territory. They could do the same thing to them when they got out of whatever sentence they received.” She said, “And weapons stockpiling isn’t technically illegal. You can own as many guns as you want. But he said that it was “some” of them, not “all” of them. Hurting the Council’s fee-fees by telling them to fuck off isn’t illegal, and it makes it sound like the Council just doesn’t like not being in control of everything having to do with wolves. They’re taking out their butthurt by sending Cleaners, like August, to kill these people. If the US Government sent out hitmen to take out everyone that criticized them, a “shit storm” wouldn’t even begin to describe it. You know who does that? Dictators. Stalin did that, Mussolini did that, and they didn’t exactly live long and full lives.”

“If these anti-wolf groups heard about what these packs are doin’--”

“It would give them ammo, yeah, but it’s not just wolves that do it. Humans do terrible things too. Wolves are wolves, but they’re also people and people suck.” She said, “He said that the Council doesn’t want a Waco incident. Waco was because of humans, that cult was run by a human. If these groups try to pull “see? Wolves are terrible” you can just list all the shit that humans have done. Hilter wasn’t a wolf, Pol Pot wasn’t a wolf, Ted Bundy and Jeffrey Dahmer weren’t wolves. Charles Manson, not a wolf. I can go on.”

“Point made, babe.” He said, “You know, I don’t think there’s a single female Alpha on the Pack Council. I think it’s all a buncha guys.”

“Maybe there should be.” Stephanie said and he picked his head up to look at her.

“Thinkin’ about goin’ into politics, doll?” He asked and she snorted.

“No, I’d be terrible at it.”

“You’d have some weight behind you. Geralt is their best Tracker, if I’m rememberin’ right and August is notorious enough as a Cleaner where he’s basically the bogeyman, apparently.” Sy said, “Get a few others on your team and you’d be a contender. I also think they’re all born wolves, not a single infected among’em, so they don’t have that human perspective. You see shit from the viewpoint of both worlds, they only see it from theirs.”

“Question for you, though.”

“Hit me.”

“You said you worked with August on a mission once when he was still with the CIA.”

“How we met, yeah.”

“Did it have anything to do with what he did with the Agency?” She asked and he sighed. “Markus.”

“Rogue Intelligence Agent was sellin’ intel and advanced arms to an insurgent faction in Iraq. We kept gettin’ blindsided, our boys ambushed on ops that were supposed to be classified.” He said, “August rocked up and gave me the rundown. I worked with him to take care of the faction, while he tracked down and got rid of the Agent. There was a lot of downtime between intel drops so we got to talkin’. We recognized each other as Alpha wolves right away and this was before the Council made the decision to go public, so it was something we bonded over. That and cards. Man’s terrible at Texas Hold’em. I think he still owes me fifty bucks, thinkin’ about it.”

“Make sure he pays up.” She said with a snort.

“Now, baby, I’m gonna need you to stop thinkin’ about another man while you’re in bed with me. Ya hear?” He asked and she laughed, rolling over onto her back partially to look up at him as he propped himself up with an elbow.

“I love you.” She said, reaching up to touch the side of his face gently.

“Love you more.”

“Not possible.”

“Babe, when Mikey was tendin’ to your arm after you first showed up, Lewis came at me tellin’ me to give you back, that you were his. You know what I told’im?”

“What?”

“Not anymore.” He said, “I wasn’t thinkin’, I just said it. You weren’t his anymore, you were mine. Geralt knew you were his Mate when you first pulled at his wolf, but I think I knew sooner than that, it just hadn’t sunk in yet.”

“I wonder when Walter knew.”

“You’d have to ask him sometime.”

“And August.”

“Nah, he probably knew the moment you told him to go fuck himself holdin’ a middle finger in his face.” He said and she snorted, “Don’t know how I didn’t declare my undyin’ love right then and there.” She didn’t say anything, tuning back onto her side and Sy settled again, his arm around her waist.

“You know what?” She asked and he hummed. “I think I would have preferred it if he had been doing porn.”

“Really?” He asked, a laugh in his voice.

“I would have sent the ladies a gift basket.” She said, “And a note saying “yeah he’s just kinda like that”.”

[pandemic-info]

Solving the puzzle of Long Covid | Science

Long Covid provides an opportunity to understand how acute infections cause chronic disease

Graphic:

Many forms of Long Covid Long Covid is a multisystemic disease with sequelae that affect almost all organ systems. Various putative mechanisms that underlie these sequelae are not mutually exclusive and may explain the myriad health effects seen in Long Covid. Therapeutics that target these pathways, such as antivirals, anti-inflammatory agents, microbiome restoration, and anticoagulant drugs, may ameliorate symptoms. GRAPHIC: A. MASTIN/SCIENCE

[nature-is-punk]

Yarrow and its Uses

Disclaimer: The below is the culmination of tedious, scrupulous research meant to assist with magical and medicinal practices. However, we lack a variety of lab-conducted herbalism trials in humans, so precautions are necessary. None of the below represents medical advice or is meant to replace treatment by a medical professional.

Identification and Profile:

Appearance: White, yellow, or pink flowers bloom from March to October. Very strong sweet smell. Often mistaken for hemlock or queen anne’s lace; leaves and flower shape are the most reliable identifiers for telling these three apart.

Distribution & Habitats: Native to temperate regions of the Northern Hemisphere. Thrives in meadows, roadside ditches, grasslands, and open forests. Attracts predatory wasps, ladybugs, and other beneficial insects. Reduces parasites in the nests of birds such as the common starling, who line their nests with it.

Associations: Yarrow was found in a neanderthal burial site in Iraq, suggesting its use by humans for more than 60,000 years. While yarrow has impressively consistent medicinal usage across cultures - namely healing and inflammatory pain relief - cultural and spiritual connotations vary. Yarrow’s botanical name refers to the legend that the centaur Chiron taught Achilles to use yarrow on the battlegrounds of Troy to heal wounds. Across the British Isles, yarrow was used to assist women in finding husbands, from divination to sleeping with the flowers under ones’ pillow. In Europe, it was known as a witch’s herb, occasionally called the Devil’s Nettle.

Uses: Topical: Effective antibacterial, astringent, antifungal, and antiseptic agent and can be applied to wounds to deter infection, speed up healing, and soothe inflamed or irritated skin. Ethanol extracted essential oil is the most lab-studied form of topical application, though dried flowers can be powdered, applied as whole dried flowers, or made into poultices and salves to wounds to stop bleeding. Oral: Flavonoids of yarrow make it a powerful antispasmodic and decent anti-inflammatory, most often used for gastrointestinal disorders. Yarrow can also induce sweat to break a dry fever. Essential oil of yarrow heals stomach ulcers. Navajo people chewed the leaves to reduce tooth and gum aches or inflammation in the mouth. Mild laxative properties. Mild sedative when consumed as tea. Tea also can be consumed to reduce headaches and cold symptoms, and sterols in yarrow can regulate menstrual cycles. Inhalation: Boiling the plant and inhaling the steam can reduce headaches and sinus inflammation. Dosage: Oral dosage is 2-4g of dried herb, flower and leaf, or 3g of whole flowers. Consecutive use is not recommended for longer than 2 weeks.

Interactions & Side Effects: - Adding nettle to yarrow consumed orally can reduce oxalate burden on kidneys. - Possibly an abortificant by relaxing the uterus, and may reduce breast milk supply while breastfeeding. - Increases production of stomach acid, lowers blood pressure, and increases risk of bleeding for those on blood-thinning medications. - Also interacts poorly with lithium based medications by increasing the body’s lithium retention.

[daisyssousa]

Hi. I hope you don't mind me asking your opinion, as a disabled person, about comments I've seen about Sousa's new prosthetic. I realize no group is a monolith, so you won't provide THE difinitive answer, but I would like hear from someone who actually lives through it.

So, why is Sousa's new prosthetic considered ableist but his old prosthetic was not? Is it because his disability is no longer obvious? But if the new prosthetic works better, why is that a bad thing? Sorry, I guess that's three questions. I really hope this didn't come off offensive, I genuinely just want to understand.

I hope your having a great day and have fun blocking the anti-Dousy trolls😊

Hi there! <333 Thank you very much for the question! It's not offensive at all!

As you pointed out, we're not a monolith, so I definitely can't speak for every disabled person out there, nor am I trying to! If someone is legitimately offended, they completely have a right to their feelings. I'm also not an amputee, so I can't speak to that either.

I think there are some people who feel that because his new prosthetic made it so that he can walk completely normally, they feel like it's erasing his disability. There are a few reasons I heavily disagree with this mindset:

It doesn't erase his disability at all: He will still have to care for his leg the same way he would with any other prosthetic. He will still have to keep it clean and take care of the skin to keep from getting it irritated, injured, or infected. He will have to keep up care of his remaining leg muscles too to be able to use it. It's mechnical and electronic, so the prosthetic itself will require maintinence and upkeep as most tech does. It's not going to be like poof! His leg is magically healed! When you get down to it: his new leg is still not his real leg.

I do think there is room for criticism in the sense that Agents of Shield didn't show this on screen. In fairness, perhaps they thought in showing Coulson and Yoyo previously struggling with their prosthetics, they thought maybe it would be enough since season 7 was already crammed. I do think they should've given us at least a little something though. But still: it didn't erase Coulson or Yoyo's disabilities, so it wouldn't erase Sousa's either.

Technological advances: With all the technological advances of the Marvel world and all of Fitzsimmons' inventions, giving Sousa a high tech prosthetic is completely within reason. It isn't like the Agents of Shield writers magically pulled special technology out of nowhere to specifically "erase" his disability, there was already a precendent set with Coulson and Yoyo (and Bucky Barnes). And also LMDs. Even Daisy's gaunlets are prosthetics in a way, since they keep her bones from breaking when she quakes.

If they'd retconned his missing leg or used some kind of hand-wavy magic to get it back, then yeah I could see the argument. But that's not what happened.

Real world technological advancements are catching up too: there are already prosthetics in development that use the electrical impulses of the brain to move the prosthetic limb and allow the person to feel sensations! There are also battery powered mechnical ones. Should real amputees be barred from using these because it "erases" their struggle? No. (btw I am not aiming this at you anon, this is me speaking in general! <3)

Sousa's wish to walk again is in character: Sousa expressed in episode 2x08 of Agent Carter: "I know desperation. You know what I'd give to be able to walk again? A lot." He even uses the word "desperate." This is fulfilling a character trait he had in Agent Carter. It didn't come from Agents of Shield. He wants to be able to walk and is accepting of the prosthetic.

It grants him more freedom of movement and less pain: Especially considering they were in the middle of a dangerous mission, giving him more movement and less pain to hinder him is extremely helpful. And in general, why shouldn't he be able to use something that helps him be in less pain and do more every day? No one should be forced to struggle just to prove they're disabled! (Again not directed at you anon, in general <3)

Anyway, my brain is turning a bit mushy, but I hope this helps you anon! <333