#university florida
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#florida gators#florida football#university florida#sec#university of fl#football sublimation#college logo#gainesville#florida sweatshirt
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sophomore year of nursing school 💙🩺
#studyblr#light academia#academiario#stem#nursing studyblr#nursing school#nursing student#study mood#study motivation#study space#studyspo#study hard#university#college#student#study blog#study aesthetic#studying#florida#classic academia#academia#academiario nursing
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"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.
The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.
The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.
“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.
“These clusters alert the immune system in a much more profound way than single particles would.”
Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.
“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.
“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).
Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.
The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.
In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.
The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...
While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.
The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."
-via Good News Network, May 11, 2024
youtube
-video via University of Florida Health, May 1, 2024
#cw cancer#cw death#cw animal death#medical news and technology#cancer#brain cancer#cancer treatment#tumor#brain tumor#florida#university of florida#medicine#biology#cell biology#mrna#mrna vaccine#vaccines#oncology#good news#hope#Youtube
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Florida State Swim
#Florida State University#Florida State Seminoles#college swimming#swimmer girls#athlete#female athletes#college athlete#college girl
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Photos of Gozer the Gozarian, Dr. Ray Stantz, Dr. Egon Spengler, and Phoebe Spengler in the new Universal Mega Movie parade at Universal Studios Florida
Photos by @motley-joey on Instagram
#ghostbusters#egon spengler#ray stantz#phoebe spengler#Universal Studios Florida#universal studios#misft makes noises
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What a horrific story this is.
“Would this have happened to Ron DeSantis’s wife? No, I guarantee it would not have. She’d have been treated right away.”
#Anya cook#news#ron desantis#democrats#republicans#blm#woc#poc#Florida#reproductive rights#donald trump#scotus#universal healthcare#health#pregnancy
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Actual view of Florida from the International Space Station
#florida#iss#international space station#space station#astronomy#astronomers#nasa#universe#nasa photos#astrophotography#astrophysics#outer space#nasawebb#hubble space telescope#i love astronomy#astronomy facts#astronauts#planetary science#space exploration#space#science#nasa science#science facts#space science#sky photography#space photography#space travel#our universe#the universe#solar system
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Mystic Fountain ⛲ Universal Orlando
#Mystic Fountain#Universal Orlando#Sindbad's Bazaar#The Lost Continent#Eighth Voyage of Sindbad#Fountain#Splash#Tree#Universal's Islands of Adventure#Universal Orlando Resort#Orlando#Florida
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Robert W. Kelley, “From Displaced Person to College Queen,” Life, Dec 15, 1952
#dance#1950s#life magazine#student#vintage#dancing#1950s fashion#50s#50s fashion#vintage fashion#florida state university#college#university#robert w. kelley#photography#black and white#photo restoration
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Yes I'm in Florida why do you ask
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Life update: I’m in nursing school! The last time I posted was when I was in community college taking pre nursing classes, and now I am in university!!! I am officially a nursing student and I get to wear scrubs as school uniform!!
#studyblr#study mood#studyspo#study aesthetic#university#college#nursing#nursing school#stemblr#study blog#study inspiration#study hard#academiario#nursing studyblr#nursing student#florida#academiario nursing
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horrible
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Rumor has it that we'll be getting Universal Studios Epic Universe "How To Train Your Dragon - Isle of Berk" details on Thursday!
#universal studios#isle of berk#epic universe#how to train your dragon#toothless#disneybound#florida
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Florida Atlantic Cheer
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Oggy and Jack !
Two absolute goofballs.
(Also Transmasc Oggy FUCKIN RULES!!!)
The Roaches
#oggy and the cockroaches#oatc oggy#oatc jack#fanart#art#digital art#small artist#humanization#au#alternate universe#chatacterdesign#goobers#cartoon#ref sheets#reference sheet#florida man
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