#so if patients are selected

[nazmazh]

Started on a new anti-migraine drug today (ajovy). Also have had terrible sleep - Especially today, but, like, all year. Also, y'know the migraines.

So not 100% sure if certain things are side-effects of the ajovy or just y'know, my body being upset with many things going on in its life - But more to the point: Should I be concerned with anything that I'm seeing/experiencing?.

Trying to google side-effects is sure a fucking trip, though.

Official company line on their site seems to be "Some swelling/irritation near injection site" is likely the only side-effect confirmed to definitely be from this medicine. Anything else? Well, that must be someone else's problem.

Various reddit posts of peoples' experiences with the medication - Mostly neutral-to-mildly positive. A lot of not-outright-negativity, but disappointment or frustration about the tradeoffs vs benefits. But the side-effects definitely vary wildly in type and intensity. The ones I'm curious about are topics of discussion that have come up with some degree of frequency.

Various interaction/drug rundown sites have much more comprehensive lists, but also include a warning that the ones I'm looking into may be serious/concerning and I should consult my doctor about them right away. Which, like, doesn't seem to be the tone regarding them anywhere else. So, more confusion as-to who's out of step here.

Meanwhile, the pamphlet that came in its box actually does have a more comprehensive list of possible side-effects. Doesn't list severity other than obvious "If experiencing anaphylaxis..." or other obvious emergencies/serious stuff, then go to ER/phone doctor immediately. Everything else listed is just sort of "This could happen" without any level of how concerned you should be.

The ones I've noticed are heartburn (Unusual for me without certain types and timings of trigger-foods, but not impossible to be something else going on that's unrelated to this). And notable joint-stiffness (hands and feet, especially on the same side as my injection), with a touch of joint pain. Both of those are in the "might happen in ~1% of patients" group. Which, hey, alright. That's fine. They're known to have a connection, echoing what the reddit posts were saying. From the tone in the pamphlet and on reddit, I probably don't need to be concerned unless they worsen or persist for a very long time.

Uncommon doesn't necessarily mean alarming, though I am curious as to if there's any correlation in the group of people that experience them. Any factor that might predict it, or explain why they're causing this reaction, y'know?

Okay. Good. No need to panic. Probably should sleep though. Less than 4 hours in the last 48 can't be good for me.

[chio-chan2artbox]

Step Forward - Part 3 They are going on a date!!! Part 1, Part 2, Part 3, Part 4 Check out my tags for fun facts XD

Kofi

[puhpandas]

i need prince gregory to be real. do u guys see my vision

based off of the original sprite under the cut

[slashthrashandcrash]

Man I have jury duty on Tuesday it better be for something good like a triple homicide

[pixlokita]

So I'm absolutely adoring your into the ballpit au and while I'm side eyeing how literally everyone is so easy at taking what's happening the biggest thing that's bothering me is when Henry was talking to Mikebear, he said, "I know you're having trouble speaking," like it's a normal thing that Mike suddenly can't speak properly? Does Mike have moments of select mutism in this verse? Either way loving this comic and can't wait for the next part.

Hiii !! Yes!!! ;v; I actually didn’t think that Henry would assume he was having trouble talking because of that, it was because of the shock but I love the idea so I’m keeping it >>)b

As for everyone dismissing things easily :’v I get that, I’ve been trying to not make it too fast paced but then it takes so much longer to get to the fun parts of the story :’> if it’s about Henry though? he doesn’t want to push the kids to say too much since he can see they aren’t doing too well and he knows not to pressure them to get answers, he’s just being patient ^^

Aaaa and thank you TTwTT💖💖💖 glad you’re enjoying the story so far 👌

[venacoeurva]

ngl I did not expect to be handed a consent form like 30 seconds into actually being seen but it went so smoothly my appointment lasted less than like 10 minutes so I'll take it

[bobby-rising]

immediately updated three dudes after the update, like zero hesitation

[lisanees]

I love my wife so so much, I'll never be able to express with words all the things she makes me feel

[unvergangliche]

i'll try to get to messages as soon as i can , thanks everyone for your patience . i'll also update my rules like i said to be more thorough and also just , kind of give myself a breather a bit ? i appreciate the new folks and also just the patience i'm being given because i'm definitely going through it across the board , so i will be very slow for well, i don't know how long until things get a bit more manageable with my health . thank you so much ! have sleepy fri.eren and lil fern . . . well, to fri.eren she will always be little :' ) .

[softquietsteadylove]

Some soft beautiful and cute moments for thenamesh Doctor au? They deserve a little break ❤️

"How is she?"

Ajak turns with a smile at the head just barely poking into the room. She waves him in, and Gil shuffles in quietly, his hands pushed deep into his hoodie pockets. "She's okay, Gil. She's coming down from the anaesthetics, her vitals all look good. Aside from some physio and some time off, she'll be just fine."

Gil chuckles, walking around to the other side of the bed with Thena sleeping soundly. "She'll be furious she has to take time off. If she comes in for physio she'll probably just slip away and try to work."

Ajak shrugs, giving him a grin, "I'm sure you wouldn't let her anyway."

"You're right."

Ajak averts her gaze as Gilgamesh reaches out to push some of Thena's hair away from her face. Maybe he's forgotten they aren't alone, or maybe he just doesn't care who sees him do it. "You know you can't take two weeks off too, right? I know you want to, but if Thena isn't here, then I'll need you more than ever."

Gil nods solemnly, his hand almost back in his pocket when he suddenly decides the place for it is around Thena's hand. "She wouldn't let me take the time off either, I'm sure. I can check on her between my shifts."

Ajak just shakes her head. It's not as if she would be able to do anything to stop him from doing so. "Just remember to get your proper rest, too."

"Yes, Ma'am," Gil offers a tired smile before looking down at Thena again. He reaches up to her hair again, but this time he trails a finger over her cheekbone, then down her jaw. "Oh, Thena."

Ajak is about to leave the two lovebirds alone when Thena shifts. "Thena?"

"Honey?" he whispers, leaning to get a look at her eyes. They're still hazy, but she blinks at him. "Hey, Sweetie, how are you feeling?"

"Hey."

Ajak's eyes sneak over to the heart monitor displaying her heart rate, blood oxygen and blood pressure readings. The heart rate has picked up speed a little, not that either of them have taken notice.

"Morning, Sunshine," Gil chuckles, visibly relieved at the sound of Thena's voice. He leans over her, liberally planting a kiss on her cheek. "How're you feeling?"

Ajak observes a funny little skipped beat, but it seems to be a momentary effect.

"I'm okay," Thena whispers to him, her eyes still struggling to open all the way. She makes the faintest attempt at pulling herself up.

"Hey, easy," Gil rushes to hold her. He wraps his arm around her shoulders, helping her up to her desired angle and bringing a cup of ice chips up to her lips.

Ajak adjusts the bed so Thena can lie down/sit up comfortably. Not that they notice that either.

Gil takes the cup from her as she swallows down the much needed water. "Better?"

She nods, her thumb moving against his absently as she tries to absorb her surroundings. She - finally! - looks over at Ajak. "What happened?"

Ajak smiles at her, pulling her blankets up again. "We got you right into surgery, got some blood in you. You're lucky it wasn't more serious."

Thena sighs, lying heavier against her pillow. "How long?"

"Two weeks, minimum," Ajak says firmly, and watches Thena make a face like a teenager being forced into a family reunion. "And that's if things heal quickly and your physio goes well."

Thena rolls her eyes at it, although she gets jabbed in her good leg with Ajak's pen for it. "Hey!"

"Don't roll you eyes at me, little lady," Ajak smirks at her, happy at least to see Thena regain some of her usual fire as she glares back at her. "I'm going to tell them that you're up. You two, wait here."

"I'll do my best," Thena grumbles, further ensuring her recovery. She smiles at Ajak on her way out before looking at Gil again. "Are you okay?"

"Me?" he asks, and then openly scoffs. "You were stuck under a car, Thena--for hours!"

"It wasn't hours."

"Well, no one would tell me how long it was!" he protested, "so I had to imagine the worst!"

Thena just sighs. She has a clear memory of him lying down with her, holding her hand and whispering sweet comforts to her as the rain and wind and her own impending death loomed over her. "Thank you."

Gil leans over her again, pressing his forehead to hers, as he had done in the moment under the car. "I wouldn't have let anything happen to you, Thena. I swear."

"I know you wouldn't," she whispers back. Her eyes flutter open again while Gil's are still closed. He's so close he's blurry, but she can make out the pinkness of his lips.

Gil pulls back, smoothing over her hair again. "Hey, what were you going to say?"

"Hm?"

"Just at the end," he frowns, twirling a long of blonde around his finger. "You started saying 'Gil if-' but I wouldn't let you finish."

"Oh."

That heart monitor is beeping faster again.

"I didn't want you to say anything because there was no if, then," he shrugs, more able to talk about it now that the immediate danger has faded a little. He tilts his head at her, "so, what was it?"

Thena's eyes dart around a little, listening to that damned heart monitor blaring her guilt. Not that it was as loud as media made them seem, but it wasn't as silent as she would like.

"I don't think I remember."

Gil tilts his head at her and her sudden unwillingness to look at him. He leans over until she has no choice but to see him (being stuck in a bed, and all). "Hey, wait."

Thena's fluster only worsens as his palm presses against her forehead. She squeezes her eyes shut, "Gil, it..."

"You look a little flushed," he frowns at her, and just now looks up at her monitor readings. "BPs kind of high too--you might be fighting an early infection. I'll get Ajak."

Gil takes off before Thena can really stop him and tell him not to. And at least it gives her a chance to try and get her traitorous heart to calm down a bit.

[dearmrsawyer]

`

[collecting--stardust]

This semester's summary: existential crisis, existential crisis, existential crisis

[lunaetis]

[ i'm going to head to bed, but a little heads up that since new year is approaching, i will be doing a followers clean up before the year ends. i've realized that my motivation to be here had fluctuated due to stress and many other factors, so i'd like to be more selective with who i follow now. it's nothing personal, ofc ! i just get really overwhelmed and pressured quite easily as of late.

the threads clean up will come after that, but i'll prioritize the followers clean up first. i'll do it bit by bit from now to new year. thank you for understanding & i hope you guys have a great day / night ! ]

[loregoddess]

the things I will do for theorycrafting

[oglegoggle]

It bothers me when folks insist that there are literally no good reasons to surrender pets because it destroys their hearts. Like…. My dude…. That evil fuckin cat that slashed my literal eyeball should be surrendered. I found new homes for my three cats because I couldn’t take having multiple panic attacks triggered every single fucking day because they’ve got claws and I’ve got a new dose of fresh PTSD caused by that demon slashing my eye. I still can’t sleep well because of the nightmares about it. The pain and the blood and the temp blindness in that eye and the extreme fear. It’s been months. My life was fucking destroyed and my love of cats ripped from my soul. But I’m the villain? No. Needs drastically change sometimes and it sucks for everyone involved. It wasn’t good for me having cats around. It wasn’t good for my cats to have their only human destabilized and constantly rejecting their affection. They’ve got a new home where all three miraculously got to stay together and are dearly loved again as they deserve to be.

[reasonsforhope]

"The first modern attempt at transferring a uterus from one human to another occurred at the turn of the millennium. But surgeons had to remove the organ, which had become necrotic, 99 days later. The first successful transplant was performed in 2011 — but even then, the recipient wasn’t immediately able to get pregnant and deliver a baby. It took three more years for the first person in the world with a transplanted uterus to give birth. 

More than 70 such babies have been born globally in the decade since. “It’s a complete new world,” said Giuliano Testa, chief of abdominal transplant at Baylor University Medical Center.

Almost a third of those babies — 22 and counting — have been born in Dallas at Baylor. On Thursday, Testa and his team published a major cohort study in JAMA analyzing the results from the program’s first 20 patients. All women were of reproductive age and had no uterus (most having been born without one), but had at least one functioning ovary. Most of the uteri came from living donors, but two came from deceased donors.

Fourteen women had successful transplants, all of whom were able to have at least one baby.  

“That success rate is extraordinary, and I want that to get out there,” said Liza Johannesson, the medical director of uterus transplants at Baylor, who works with Testa and co-authored the study. “We want this to be an option for all women out there that need it.”

Six patients had transplant failures, all within two weeks of the procedure. Part of the problem may have been a learning curve: The study initially included only 10 patients, and five of the six with failed transplants were in that first group. These were “technical” failures, Testa said, involving aspects of the surgery such as how surgeons connected the organ’s blood vessels, what material was used for sutures, and selecting a uterus that would work well in a transplant. 

The team saw only one transplant fail in the second group of 10 people, the researchers said. All 20 transplants took place between September 2016 and August 2019.

Only one other cohort study has previously been published on uterus transplants, in 2022. A Swedish team, which included Johannesson before she moved to Baylor, performed seven successful transplants out of nine attempts. Six women, including the first transplant recipient to ever deliver a baby back in 2014, gave birth.

“It’s hard to extract data from that, because they were the first ones that did it,” Johannesson said. “This is the first time we can actually see the safety and efficacy of this procedure properly.”

So far, the signs are good: High success rates for transplants and live births, safe and healthy children so far, and early signs that immunosuppressants — typically given to transplant recipients so their bodies don’t reject the new organ — may not cause long-term harm, the researchers said. (The uterine transplants are removed after recipients no longer need them to deliver children.) And the Baylor team has figured out how to identify the right uterus for transfer: It should be from a donor who has had a baby before, is premenopausal, and, of course, who matches the blood type of the recipient, Testa said...

“They’ve really embraced the idea of practicing improvement as you go along, to understand how to make this safer or more effective. And that’s reflected in the results,” said Jessica Walter, an assistant professor of reproductive endocrinology and infertility at Northwestern University Feinberg School of Medicine, who co-authored an editorial on the research in JAMA...

Walter was a skeptic herself when she first learned about uterine transplants. The procedure seemed invasive and complicated. But she did her fellowship training at Penn Medicine, home to one of just four programs in the U.S. doing uterine transplants. 

“The firsts — the first time the patient received a transplant, the first time she got her period after the transplant, the positive pregnancy test,” Walter said. “Immersing myself in the science, the patients, the practitioners, and researchers — it really changed my opinion that this is science, and this is an innovation like anything else.” ...

Many transgender women are hopeful that uterine transplants might someday be available for them, but it’s likely a far-off possibility. Scientists need to rewind and do animal studies on how a uterus might fare in a different “hormonal milieu” before doing any clinical trials of the procedure with trans people, Wagner said.

Among cisgender women, more long-term research is still needed on the donors, recipients, and the children they have, experts said.

“We want other centers to start up,” Johannesson said. “Our main goal is to publish all of our data, as much as we can.”"

-via Stat, August 16, 2024