#remission for chronic fatigue and pain

[tumble-tv]

Had to leave school early again because the pain was making me nauseous, and I couldn't focus, and I was struggling to stand for more than like 30 seconds. I hate this. I missed a cool assembly because of this. I missed my favorite class because of this. I'm so tired.

[afniel]

Every morning my brain spins a little wheel and picks what's going up be fucked up that day. Usually it's my pain perception or energy level, sometimes it's my mood, sometimes it's my sense of balance and I could do without that, but VERY OCCASIONALLY it will Mad Lib slap together, "TODAY'S BROKEN THING: your (noun:[ability]) (verb:[to sense that]) (object:[you are disabled])," and today is one of those days. I feel fucking good? I slept well? I jogged big sections of the way to lunch because I could? My legs didn't cramp up? I'm in a super good mood?

This happens so rarely that I actually register it as a problem and go through the day thinking, oh no have I finally developed bipolar, is this mania, and it's like, no, dipshit! It's functioning. Of course it feels good and you feel good about it. There's nothing wrong with having nothing wrong with me for a moment. You really don't understand how disability changes you until you're wondering if your temporary relief is a mental illness...

But enough of that, I'm having a good day and I hope everyone else is too, and if you aren't, I hope you'll have one very soon. 💜 ✌️

[ghosty206]

.

[fletchingbrilliant]

🌙some wildly cheap commissions!🌙

🙃 for some even wilder reasons 🙃

hey y'all. long post thingie but it's got cute pictures so please check it out

TRANSCRIPT OF POST

hey frens got something kinda somber to talk about. most of you are very aware of the existence of my beautiful fiance and co-creator of basically everything i do. zae and i are getting handfasted (marriage for pagans) in october, and have been living together for about 10 years. in 2021, zae got really fucking sick, and after a few false starts, was diagnosed with a rare for of vasculitis called granulomatosis with polyangiitis, GPA for short. it’s an autoimmune disease that causes inflammation in blood vessels and other tissues, ultimately stopping blood from getting to the parts of the body that need it, affecting many areas, but primarily the respiratory system. while the cause isn’t known, it usually presents in people in their 50’s or 60’s, but complications from a third bout of covid-19 appears to have made it emerge way earlier for our boy. at least, that’s what we think. his case is extremely aggressive, advancing faster than anyone could have expected. in zae’s case, it actually attacked his kidneys first, and then went after his lungs, causing both to threaten shutting down for good. he was extremely anemic and needed a ton of transfusions, narrowly avoiding dialysis, and we spent weeks in the hospital keeping him alive. he was placed on two different kinds of chemotherapy to combat the disorder. he lost his hair, went through even more fatigue and pain on top of what the disease had already put him through, and had to accept a plethora of changes to his life that will last forever. a lot of you out there have harrowing experiences of your own when it comes to chronic and potentially terminal conditions, too, I’m certain. “it’s not fun” is an understatement. though there were a couple of really fucking close calls, zae’s GPA went into remission. his hair grew back fuller and more luscious than it had ever been before. (i later learned these are affectionately referred to as “chemo curls.”) remission for gpa is usually expected to last at least 5 years, potentially up to 20, before any symptoms resurface. but zae’s case was particularly aggressive, so of course he’s not so lucky. he’s relapsing now. his symptoms have been slowly returning, and it’s been decided that he’s going back on chemo. it’s no surprise that this shit is expensive, even with insurance. we’re still paying off the care he received last time because ‘murca. being disabled myself, work has been… let’s call it inconsistent, yeah? yeah, that’s a nice and comfortable thing to call it. no one’s doing well financially these days, so we of course have to get creative. long story short(er), i’m doing a commission special! for the next MONTH, i am offering fast commissions at crazy-low prices to try and help us create a cushion to keep us afloat and relatively comfortable while we begin the chemo process again. there’s several options for a variety of budgets, because i really hate the idea of seeking something for nothing, and i absolutely abhor having to reach out in this way. it makes me feel vulnerable and icky and… i’m sure you all understand that, too. i can’t thank you all enough just for following me, and engaging with mine and zae’s work. it may sound trite, but that really makes a difference to us, especially when we’re dealing with something so painful. so if you can’t or don’t want to partake of the sale, please know that you are still a huge help to us, and we seriously appreciate each and every one of you. like, so fucking much. thanks y’all love, fletch

END TRANSCRIPT

Commission Options:

Flash Sketches: $5USD/character

Comics: $5USD/panel - flat color

Comics: $10USD/panel - shaded color

Screenshot Redraws - $15USD/character (complex bgs, add $20)

all of this is posted with @zaebeecee's knowledge and blessing

please DM me if you're interested in something, and thank you again

more Hungry Games, fic fanart, and Persona stuff coming soon too

[thornfield987-blog]

I know this has been done before but here’s my headcanons for LU Chronic illness/Disability boys:

Legend(he/they): Hypermobile type Ehlers Danlos syndrome. Frequently dislocates joints and doesn’t see why the others make such a big deal about it, it happens all the time! Primarily suffers from widespread join pain, instability and chronic fatigue. Has as many different mobility aids as they have magical artifacts.

Time(he/him?): Early onset osteoarthritis and partially blind. All of the time travel and shifting forms was not kind to his joints, so the connective tissue was damaged and BOOM. Arthritis. The old man jokes are becoming less and less of a joke every day. Also experiences debilitating migraines.

Hyrule(they/he): Sensory Processing Disorder (often associated with autism but can be caused by other conditions). Their magic sensitivity can often cause overstimulation in their other senses, and they are very sensitive to light, sound, smell and touch. They are semi-verbal because even his own voice can overstimulate him sometimes, but they don’t know sign very well. Also has anemia.

Wild(genderfluid he/she/they): hypertrophic contractural scarring, partially deaf, semi-verbal because of vocal cord scarring. Also prosthetic arm(set after TOTK). She switches between sign and speaking, whichever is easiest for him that day. They have to perform daily stretches and apply scar lotion to be functional, but they aren’t very good at remembering to do so. Often blows out his voice because he gets excited, but can’t tell how loud he is speaking.

Four(plural they/them): Dissociative Identity Disorder(but not really because of magical reasons), damaged growth plates because of Minish magic. They have very similar symptoms to DID, but there are slight differences because it was caused magically and traumatically, not like in the real world. They sometimes struggle to walk correctly because their growth plates are damaged, causing their legs to be slightly different lengths. They wear adaptive shoes to correct this.

Sky(he/him): POTS(Postural Orthostatic Tachycardia Syndrome), chronic fatigue. He struggles to breathe the denser air on the Surface, but he struggled with it on Skyloft as well. He has a chronically higher heart rate that causes dizziness and (rarely) passing out when moving from sitting to standing, after eating, and after adrenaline rushes. This causes his stamina to be fairly low, and also causes chronic fatigue.

Twilight(he/him): RRMS(Relapse/Remission Multiple Sclerosis). This is caused magically by the Twilight curse eating away at his body’s nerves, but is kept mostly under control by his shadow crystal. Occasionally, he goes through relapses and experiences anything from tingling and numbness in a limb to temporary loss of vision in one or both eyes, balance issues, vertigo and slurred speech. These flares are almost always debilitating, but thankfully they only happen every couple of months and last from a few days to about a week.

Wind(he/him?): A little cliche, but he has a peg leg. He likes to tell outlandish stories about it getting bit off by a kraken or eaten by a cannibal, but the truth is that he got an infection, couldn’t treat it in time and had to amputate. This happened sometime after his quests had finished, and he’s still a little ashamed of the actual circumstances, so he doesn’t open up often.

(edit) I FORGOT WARRIORS

Warriors(he/him): Speaking Disfluency (Stutter). Often repeats sounds, such as “G-g-g-guys”, or extends sounds; “Llllllll-Iove you”. He grew up poor, so he was never able to get treatment for it, so he communicates using sign while Proxi translates verbally, though this isn’t as necessary with the Chain since most of them know sign.

[themogaidragon]

just curious.... do you know of a general/unspecified chronic illness flag?

Nope so I've made some using those chronic fatigue flags.

Chronic Illness Pride Flag

[IMAGE ID: a flag with six horizontal stripes. The fisrt and last stripes are smaller. Their colors are, from top to bottom, dark bluish green, light salmon pink, soft white, bluish green, light bluish green and dark bluish green. END ID.]

[IMAGE ID: a flag with a dark bluish green background. Lines, like brushstrokes, which go from top to bottom and from bottom to top, partially cross the flag. The line colors are light salmon pink, soft white, bluish green and light bluish green. END ID]

I choose to make the flags main's colour bluish green because light blue is often used to represent chronic illnesses and because green is often used on chronic fatigue/pain flags.

Meanings of flag:

dark bluish green: fighting against ableism

light salmon pink: community and solidarity

soft white: remissions and relapses

bluish green: chronic fatigue and brain fog

light bluish green: all the types of chronic illnesses

*my requests aren't curently opened, I just really wanted to make some flags for chronic illnesses.

[stargazer-sims]

List 5 facts about a favorite sim of yours, and send this to 10 simblrs whose sims you adore ♥♥♥

Thanks for the ask @honeybeenrw!

I’m going to do this for James (as an excuse to introduce him properly since we’ll be seeing more of him in the story).

James Fairchild

He's living with rheumatoid arthritis, which is a chronic illness and autoimmune disorder. Among other symptoms, he has chronic fatigue and chronic pain and inflammation in his joints, which makes it difficult for him to be as physically active as he'd like. There are times when his illness is in a clinical remission and he has very little pain, and there are times when it flares up and he can barely do anything. Even though he's capable of walking and does so as often as he can, he regularly uses a wheelchair when he goes out because too much walking is exhausting and painful. His wheelchair gives him the freedom to do more things during the day. (bonus: one of his favourite recurring jokes is the look on people's faces when they meet him for the first time and he's in his wheelchair and he abruptly stands up at some point in the conversation to stretch or to reach for something).

He’s divorced. He and his ex-wife Alicia were only married for about five years, but she left him because she said couldn’t cope with what she referred to as his “extraordinary support needs”. James does have his share of ongoing medical issues and he does need help with some things, but in reality he’s very self-reliant a majority of the time. He assumed she was making up an excuse to cover up infidelity, although he never had actual proof of that. What James and Alicia didn't realize when they separated was that she was pregnant with their first (and only) child, but when they did find out, Alicia didn't move back in and they decided to go ahead with their divorce anyway. James supported Alicia throughout the pregancy and was there when their daughter Ava was born. Ava is now ten years old, and James has always been involved in her life.

While Alicia got married again, James hasn't found anyone new since the divorce. He's gone on plenty of dates and certainly knows how to charm the ladies, but he still hasn't been able to find The One. People are naturally drawn to him, but no one seems to stick around, and he's beginning to feel very discouraged about it.

His secret talent is sewing. He learned the basics in Home Economics in high school and liked it, but never imagined he'd take it up as a hobby later in life. It began when Ava was four, and she told him that she wanted to wear a princess dress for her fifth birthday party. She described her dream princess dress to him, but they couldn't find anything like it anywhere, so impulsively James decided he was going to try to make one. To say the pattern he found online was way beyond his skill level at the time would be an understatement, and he didn't take into account how sewing might affect the joints in his hands and fingers, but he was determined. He bought a sewing machine and supplies, and did battle with it for a month, and ripped out more stitches than he could count, but finally he succeeded. It definitely wasn't perfect, but it was done before Ava's birthday, and she loved it. He's been making dresses for Ava's birthday every year since, and getting progressively better at it. He also hems his own trousers and makes random things for his house like curtains, decorative pillows, chair seat covers and aprons.

He loves the water, particularly the ocean. He'd happily live at the beach if he could. Every year, he looks forward to his mid-winter vacation when he can fly off to some exotic sun destination and soak up all the vitamin D and ocean air he wants. He's not the strongest swimmer, but that doesn't stop him from having a good time. He also enjoys sailing, fishing and zipping around on his jet-ski.

[lucifer-is-a-bag-of-dicks]

there's this nasty little side effect to chronic pain remission, where if the pain does return you get hit in the gut with the Big Sads pretty hard

the thing about managing chronic pain is that you don't get to relax, you have to be so aware of your limits and movements, you have to stay just the right amount of active, you need expensive upkeep and preventative care, you work so hard to stay pain free and even then it's only tentative pain free

so when life throws you a curveball like flooding your neighbourhood and you have to help move and clean up large items of furniture, there's really no way to prepare for that, you can't exactly negotiate with a natural disaster

so you end up crippled and hobbling, can't even unload the fucking dishwasher, and you're hit with that feeling that you've just slid all the way back down to the bottom of the mountain and now you have to crawl back up through the mud

you were so careful, you spent so much time, money, and effort to get to where you were, and now one unexpected, unavoidable event has you back to square one

and I know the climb likely won't be anywhere near as arduous as the first time, because I've put so much effort (and MONEY) into those preventative measures, into strengthening my body so it can bounce back more easily

but it really fucks with your head, being back at the bottom of that mountain, looking up and thinking about that gruelling climb through the mud, because even if you've done a lot to prepare for this, the only previous experience you have was that first awful, terrible, painful, miserable climb, and that's all you can think about

my appetite is fucked, my adhd is rampaging because I can hardly do anything stimulating enough, and family are sympathetic for now but I know from experience that eventually the compassion fatigue sets in, and people expect you to just get on with things, even if the pain hasn't changed, even if you're still barely mobile

the crippling pain is a good enough reason to wish for this flare up to end, but honestly more than anything I don't want to go through having my mother demand household chores from me when I can barely walk, again

it's a special kind of pain, that one, when people you love go from asking if you're okay and making you dinner, to treating you like you just aren't trying hard enough to get better, acting offended that your disability is inconveniencing them now

chronic pain teaches you that sometimes compassion has a time limit

it's been long enough right? surely you're used to it by now? you can't just keep using it as an excuse, go unload the fucking dishwasher

[carnalhaus]

How did Val become a vampire

the short answer ? he didn’t.

the real answer ? it’s always been a delusion.

long post incoming lol

renfield’s syndrome isn’t a medical diagnosis, but it’s a parodied term for the symptom of an obsession with drinking blood. renfield’s syndrome can stem from various illnesses, usually associated with delusions, trauma, and paraphilias.

in val’s case, his renfield’s syndrome stems from somatic delusion. somatic delusions refer to beliefs that an individual’s body has something physically or medically wrong with it. this delusion may occur with tactile or olfactory hallucinations. val’s delusion in particular is that he needs to drink blood in order to survive, or else he’ll get very sick.

delusions can be caused by several factors, including genetic, biological, or environmental. with val, there may be some genetic causes that’ve been passed down from family, but it’s majorly environmental. according to the cleveland clinic, people who tend to be isolated, such as immigrants and those with poor sight and hearing, appear to be more vulnerable to developing delusions. val was born to immigrant parents in an isolated kansas settlement, with the entire county only having a population of roughly 1,800 at the time (1980s). val was also born legally blind due to OA type albinism.

for most people, the delusions are often chronic, though many have remission periods and can find relief with treatment. however, many people don’t seek help, as it’s very difficult for the person to recognize they’re unwell, and thus the condition can be lifelong. this is val’s case, as he wholeheartedly believes this delusion as fact.

continuing on renfield’s syndrome, in the past, some people have said renfield’s and clinical vampirism have been slightly different. clinical vampirism was associated more with an erotic obsession, while renfield’s was associated more with a form of disordered eating. even though they’re considered the same thing now, the previous distinction of renfield’s closely fits val.

psychologists have theorized the condition may start with autovampirism and progress to drinking the blood of animals, and in serious cases even people. val never had an autovampirism period, as it didn’t align with his delusion, and instead skipped to the animal period, which did.

very few cases of this behavior have been formally studied, so most information is left up to logical theorizing and analysis from known cases. the etiology is officially unknown, which leaves a lot of possibilities.

as for the effects of this behavior, vomiting is most common. if too much blood is absorbed during digestion it’s very possible for it to lead to hemochromatosis, especially when the blood isn’t accompanied by any food. with val, he might commonly have symptoms of vomiting, fatigue, lethargy, abnormal heart rhythm, memory fog, and joint pain. val’s belief that he’ll get sick without drinking blood is very real for him, as the symptoms of drinking blood are in his mind more of withdrawal symptoms. this sickly state is his typical one.

but why does val have this delusion ?

it’s because of his parents. nelu and erzsébet valentinescu are suspected to hold some degree of delusional behavior as well, which may very well be a genetic explanation for val’s condition. they were incredibly superstitious people, and used traditional superstitions and legends to justify their beliefs against val. it mainly started when he started getting old enough to show signs of his physical deformities, blind eyes, pale skin, sharp and malformed teeth (val’s ailments are likely due to the age of his parents, as they were 39 and 37 when he was born). they led themselves to believe he was some sort of strigoi, cursed by a witch in the womb.

they did care for him though, even though from an outside perspective it would be seen as very cruel, val always felt very loved. he was fed animal blood frequently, both him and his parents believing it would help him feel better (they lived on a farm and used livestock for food, that’s how he got it). val grew up believing that his parents were helping him, and his parents believed they were making the best of birthing a monster. his mom used to tell him, as a bedtime story, that he swallowed a lidérc when he was young, and it possessed him to become what he is now. a lidérc is a form of hungarian vampire, sometimes taking the form of a falling star.

[cfs-crohns-colitis-warrior]

IBD stands for inflammatory bowel disease. There are two main types of IBD: Ulcerative Colitis and Crohn’s Disease.

Ulcerative Colitis (otherwise known as UC) affects the large bowel.

Crohn’s Disease affects the who digestive tract, from mouth to anus.

IBD is an autoimmune disease, whereby your immune system attacks your body, and where it attacks depends on which version of IBD you have.

Both conditions can affect everyone differently, and some people manage better than others, through no fault of their own of course. Some people have long periods of remission and very little medication. Some people require long term medication. Some people require surgery.

No matter how your IBD is treated, the identifying symptoms are always the same. The symptoms include, but are not limited to:

- Needing the loo a lot, diarrhoea

- Blood in poo

- Sickness and nausea

- Stomach pains

- Fatigue

Anyone who suffers with IBD knows it’s no walk in the park, and there’s currently no cure. All we can do is try our best to manage our symptoms.

If you know multiple people with IBD, don’t expect them all do be able to do the same things or cope with their illness in the same way. IBD, just like any other chronic illness, affects everyone differently.

If anyone would like to reblog with more information, if you think I’ve missed anything or just want to add things I might not be aware of, please feel free to do so!

Happy World IBD Day!

[mcatmemoranda]

Clinical features – Ulcerative colitis is characterized by recurring episodes of inflammation limited to the mucosal layer of the colon. It commonly involves the rectum and may extend in a proximal and continuous fashion to involve other parts of the colon.

Patients with ulcerative colitis usually present with diarrhea, which is frequently associated with blood. Associated symptoms include colicky abdominal pain, urgency, and tenesmus. Patients with mainly distal disease may have constipation accompanied by frequent discharge of blood and mucus.

Patients may also have fever, fatigue, and weight loss. Ulcerative colitis primarily involves the intestine but may be associated with several extraintestinal manifestations.

●When to suspect ulcerative colitis – Ulcerative colitis should be suspected in patients with chronic diarrhea for more than four weeks. The clinical presentation, including laboratory features, endoscopic appearance, and radiology findings, is not specific for ulcerative colitis, and may be seen in a number of other causes of colitis including Crohn disease, radiation colitis, ischemic colitis, infectious colitis, and colitis related to medications.

●Establishing the diagnosis – The diagnosis of ulcerative colitis is based on the presence of diarrhea for more than four weeks and evidence of chronic colitis on endoscopy and biopsy. Since these features are not specific for ulcerative colitis, establishing the diagnosis also requires the exclusion of other causes of colitis by history, laboratory studies, and by biopsies of the colon.

●Disease course – Patients with ulcerative colitis usually present with attacks of bloody diarrhea that lasts for weeks to months. The course of ulcerative colitis typically consists of intermittent exacerbations alternating with periods of complete symptomatic remission. However, a small percentage of patients have continuing symptoms and are unable to achieve remission. Overall, patients who present initially with proctitis have a more benign disease course and frequently respond to topical therapy, whereas those who present with more extensive disease require systemic therapy and have a higher risk of colectomy.

Extension of colonic disease is seen in up to 20 percent of patients within five years. Approximately 67 percent of patients have at least one relapse within 10 years following the diagnosis. The risk of relapse depends on the age at initial diagnosis. The likelihood and timing of colectomy depends on the extent of the disease and severity at presentation. Mucosal healing in response to treatment is an important predictor of long-term clinical outcomes.

●Complications – Complications associated with ulcerative colitis include severe bleeding, toxic megacolon, perforation, strictures, and the development of dysplasia and colorectal cancer. Patients with ulcerative colitis may have a slightly higher mortality as compared with the general population.

Defining disease severity and risk – Patients with mild to moderate ulcerative colitis (UC) are identified as low risk based on prognostic factors that suggest a nonaggressive form of disease: absence of deep mucosal ulcerations, no extraintestinal manifestations, and diagnosis at age >40 years. These patients usually have mild to moderate symptoms (≤6 stools daily with or without blood) and lack signs of systemic inflammation (ie, normal or minimal elevation in C-reactive protein and/or fecal calprotectin levels).

●Pretreatment evaluation – For patients with UC who present with symptoms of a disease flare (eg, diarrhea, rectal bleeding), some aspects of the initial evaluation (eg, laboratory and stool studies, lower endoscopy) are repeated to exclude other conditions as a cause for symptoms and to assess the extent and severity of disease.

●Goals of therapy – The treatment goal for patients with active UC is to achieve clinical and endoscopic remission by demonstrating complete mucosal healing. Response to therapy can be determined by assessing symptoms and laboratory testing and can be supplemented by endoscopy with biopsies as needed.

●Induction therapy for ulcerative proctitis or proctosigmoiditis – For low-risk patients with ulcerative proctitis or proctosigmoiditis, we suggest topical (rectal) mesalamine rather than oral mesalamine or observation (table 1) (Grade 2B). However, for patients who prefer to avoid the burden of daily topical treatment, it is also reasonable to use oral mesalamine or to observe and initiate treatments if disease progresses.

For patients with mild to moderate disease confined to the rectum, we typically initiate treatment with mesalamine suppository once daily (algorithm 1). For patients with mild to moderate disease extending above 18 cm from anal verge into the sigmoid colon, we treat with mesalamine enema once or twice daily.

For low-risk patients with ulcerative proctitis or proctosigmoiditis who do not have symptom improvement after four weeks of topical mesalamine therapy, subsequent options include adding a topical glucocorticoid (eg, suppository, enema), adding an oral 5-aminosalicylic acid (5-ASA) agent, and/or starting an oral glucocorticoid (eg, budesonide multimatrix). Selection of second-line therapy depends on patient preferences, product availability, clinician preferences, and prior response to therapy.

●Induction therapy for left-sided or extensive UC – For low-risk patients with left-sided or extensive mild to moderate UC, we suggest a combination of an oral 5-ASA agent plus rectal mesalamine for induction therapy rather than oral 5-ASA monotherapy (Grade 2B). We begin high-dose oral mesalamine (ie, >3 grams daily) and mesalamine enemas once daily.

●Maintenance therapy – We suggest long-term maintenance therapy for the following low-risk patients who have achieved clinical remission with medical therapy (Grade 2B):

•Patients with ulcerative proctitis and >1 disease flare per year

•Patients with ulcerative proctosigmoiditis

•Patients with UC proximal to the sigmoid colon (i.e., left-sided colitis and extensive colitis)

The choice of maintenance therapy depends on the specific agent used to induce remission, the distribution of disease, patient preferences, clinician preferences, and insurance coverage/cost. For low-risk patients with mild to moderate UC in remission, the goal of management is to prevent clinical and endoscopic relapse.

●Health maintenance – Routine health maintenance, including screening for and prevention of other diseases as well as monitoring for adverse effects of therapy, is an important aspect of the care of patients with inflammatory bowel disease. 

[zhaoneurology]

What Is The First-Line Treatment For Multiple Sclerosis?

The first-line treatment for multiple sclerosis (MS) aims to modify the course of the disease, manage symptoms, and reduce the frequency and severity of relapses. MS is a chronic autoimmune disease that affects the central nervous system (CNS), leading to the deterioration or permanent damage of nerve fibers and their protective covering, the myelin sheath. Early intervention with first-line treatments is critical in slowing the progression of the disease and improving the quality of life for patients.

Disease-Modifying Therapies (DMTs)

Disease-modifying therapies (DMTs) are the cornerstone of first-line treatment for MS. These medications are designed to modify the course of the disease by targeting the underlying immune system dysfunction that causes the immune system to attack the CNS. DMTs are primarily used in relapsing forms of MS, which include relapsing-remitting MS (RRMS), where patients experience episodes of worsening symptoms (relapses) followed by periods of remission.

Several DMTs are approved as first-line treatments for RRMS, including:

Injectable DMTs:

Interferon beta (IFNβ): This is one of the most commonly prescribed first-line treatments for MS. It works by modulating the immune response and reducing inflammation in the CNS. Common forms include IFNβ-1a and IFNβ-1b. It has been shown to reduce the frequency of relapses and delay disease progression.

Glatiramer acetate: Another popular injectable DMT, glatiramer acetate works by modifying the immune response to protect nerve cells from attack. It also helps reduce relapse rates and the number of new lesions in the brain.

Oral DMTs:

Fingolimod: This oral medication works by trapping immune cells in the lymph nodes, preventing them from attacking the CNS. Fingolimod has been shown to reduce relapse rates and new lesion formation.

Dimethyl fumarate: This drug has anti-inflammatory effects and may protect nerve cells from damage. It has been demonstrated to reduce relapse rates and delay progression in MS patients.

Monoclonal Antibodies:

Ocrelizumab is a monoclonal antibody that targets and depletes certain B cells, a type of immune cell that plays a role in MS. It is used for both relapsing and primary progressive forms of MS, showing promise in improving outcomes in these patients.

Symptom Management

While DMTs address the underlying disease progression, managing MS symptoms is equally important in improving patients' quality of life. Symptoms such as fatigue, spasticity, pain, and bladder dysfunction are common in MS and may require additional treatments, such as physical therapy, medications for spasticity (e.g., baclofen or tizanidine), and pain management strategies.

In summary, the first-line treatment for MS involves using disease-modifying therapies, including injectable, oral, and monoclonal antibody medications, to reduce relapses, manage inflammation, and slow disease progression. Managing symptoms is also crucial to improving daily functioning and overall well-being for MS patients. Early diagnosis and treatment are essential for better long-term outcomes in individuals living with MS.

[vedamgastrohospital]

Understanding Irritable Bowel Syndrome (IBS): Symptoms and Treatment

Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder that affects millions of people worldwide. Despite its prevalence, IBS remains poorly understood by many, including those who suffer from it. This blog post from the best gastro hospital in Surat, Vedam Gastro Hospital, aims to shed light on the symptoms, causes, and treatment options for IBS, helping readers better understand this complex condition.

What is Irritable Bowel Syndrome?

IBS is a functional gastrointestinal disorder, meaning it affects how the gut works without any visible structural abnormalities. It’s characterized by recurrent abdominal pain and changes in bowel habits, such as diarrhea, constipation, or a combination of both. IBS is a chronic condition that can significantly impact a person’s quality of life, but it doesn’t increase the risk of more serious gastrointestinal diseases like colorectal cancer.

Symptoms of IBS

The symptoms of IBS can vary from person to person, but typically include:

Abdominal pain or cramping

Bloating

Gas

Diarrhea or constipation (sometimes alternating)

Mucus in the stool

Changes in appearance of bowel movements

Changes in how often you are having a bowel movement

Gastroenterologists consulting at Vedam Gastro Hospital, who are also well-known as the best stomach specialists in Surat, warn that some people may also experience non-gastrointestinal symptoms such as fatigue, difficulty sleeping, anxiety, and depression. It’s important to note that symptoms can fluctuate over time, with periods of flare-ups followed by periods of remission.

Causes and Risk Factors

The exact cause of IBS is unknown, but several factors are thought to play a role:

Abnormal muscle contractions in the intestine

Severe infection in the gastrointestinal tract

Early life stress or trauma

Changes in the microbes in the gut

Food sensitivities

Mental health conditions like anxiety and depression

Certain factors may increase your risk of developing IBS, including:

● Age: IBS tends to occur in people under 50

● Gender: Women are more likely to develop IBS

● Family history: Having a close relative with IBS increases your risk

● Mental health issues: Anxiety, depression, and other mental health disorders are associated with IBS

Diagnosis

There’s no single test to diagnose IBS. Instead, the best stomach specialist in Surat typically use a combination of methods:

Medical history and physical exam

Symptom-based criteria (such as the Rome criteria)

Tests to rule out other conditions (like celiac disease or inflammatory bowel disease)

These may include blood tests, stool tests, and in some cases, colonoscopy or other imaging studies.

Treatment Options

While there’s no cure for IBS, several treatment options from the best stomach hospital in Surat can help manage symptoms:

Dietary Changes

Many people with IBS find that certain foods trigger their symptoms. Common strategies include:

● Following a low FODMAP diet

● Increasing fiber intake (for constipation-predominant IBS)

● Avoiding trigger foods (common ones include dairy, caffeine, and fatty foods)

● Staying hydrated

Stress Management

Stress can exacerbate IBS symptoms. Techniques that may help include:

● Regular exercise

● Mindfulness meditation

● Cognitive-behavioral therapy

● Relaxation techniques like deep breathing or progressive muscle relaxation

Medications

Depending on your symptoms, our doctors from Vedam Gastro Hospital, the best stomach hospital in Surat, might recommend:

● Antispasmodics to relieve abdominal pain

● Laxatives for constipation

● Anti-diarrheal medications

● Antidepressants (which can help with pain and depression)

● IBS-specific medications like linaclotide or lubiprostone

Probiotics

Some studies suggest that certain probiotics may help alleviate IBS symptoms, although more research is needed in this area.

Alternative Therapies

Some people find relief with alternative therapies such as acupuncture or hypnotherapy, although scientific evidence for these is limited.

Living with IBS

Living with IBS can be challenging, but with the right management strategies, many people are able to control their symptoms effectively. It’s important to work closely with your healthcare provider to develop a treatment plan tailored to your specific symptoms and needs.

Remember, what works for one person may not work for another, so don’t get discouraged if you need to try several approaches before finding what works best for you. Keep a symptom diary to help identify triggers and track the effectiveness of different treatments.

While IBS is a chronic condition, it’s not life-threatening, and many people are able to manage their symptoms and lead full, active lives. If you think you might have IBS, don’t hesitate to speak with your doctor. With proper diagnosis and treatment, relief is possible.

Understanding IBS is the first step towards managing it effectively. By learning about the condition, identifying your triggers, and working with healthcare professionals, seeking treatment from the best gastro hospital in Surat, like Vedam Gastro Hospital, you can develop strategies to minimize the impact of IBS on your daily life and improve your overall well-being.

[patientexperts12]

Best Rheumatoid Arthritis Treatment Options Available in Dubai: A Comprehensive Guide

Rheumatoid arthritis (RA) is a chronic inflammatory illness that affects more than just the joints. It can also harm other organs, including the skin, eyes, lungs, hearts, and blood vessels. If you are looking for the Best Rheumatoid Arthritis Treatment in Dubai, Patientexperts.co can help you connect with the right rheumatology doctors in Dubai. 

RA is an autoimmune condition, which means that the body's immune system attacks its tissues. Joint injury frequently affects both sides of the body. This is one distinction between RA and Osteoarthritis.

Symptoms

Joint discomfort and inflammation occur during flares, also known as exacerbations. They also occur during remission, which is when all symptoms disappear. Although rheumatoid arthritis affects other body systems (as previously stated), the following symptoms and signs are included: 

Joint swelling 

Joint discomfort

Joint stiffness 

Deformities or lack of joint function 

Fatigue

Morning stiffness

Joint stiffness 

Joint discomfort

Minor joint oedema

Fever 

Numbness and tingling

Reduced range of motion

According to Rheumatology Specialist doctors in Dubai, several different symptoms can be felt during the early stages: 

Dry mouth

Weight loss

General weakness

Dry, itchy, or irritated eyes 

Problems sleeping 

Eye discharge 

Chest pain while breathing

Loss of appetite 

Treatment alternatives 

Although there is no cure for RA, many clinical studies show that remission is achievable if symptoms are identified early and treated with pharmaceuticals known as disease-modifying antirheumatic drugs (DMARDs). 

Medications 

Medications are prescribed based on the specific type of RA, the severity, and the duration of your symptoms. According to rheumatologists in Dubai, the following options exist: 

NSAIDs: These are nonsteroidal anti-inflammatory medications. They aid in relieving pain and reduce inflammation. Over-the-counter NSAIDs include ibuprofen and naproxen sodium. Other stronger choices will be accessible with a prescription. Side effects include stomach infections and heart and renal difficulties. 

Steroids: Corticosteroids are typically used by doctors to swiftly ease pain. Corticosteroid medicines, such as prednisone, help to reduce inflammation and joint degeneration. These are administered to progressively lower the dosage over time. Side effects include bone weakening, weight gain, and/or diabetes. 

Conventional DMARDs: They assist in halting the progression of RA and prevent irreparable damage to the joints and other tissues. Common DMARDs include methotrexate, leflunomide, hydroxychloroquine, and sulfasalazine. Common adverse effects, if occurring, include life damage and serious lung infections. 

Biological agents: This is a relatively new family of DMARDs that is typically used in conjunction with conventional DMARDs. Abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, sarilumab, and tocilizumab are all examples of biological response modifiers. Even they pose a danger of illness. 

Therapy 

Doctors at the leading hospitals in Dubai may send you to a physiotherapist, who will teach you basic and effective exercises to keep your joints flexible. He may also propose alternative and easier ways to complete fundamental chores. 

You may also be recommended assistive gadgets geared at reducing stress and joint pain, making it easier for you to do tasks. 

Surgery

Any rheumatologist in Dubai will agree that surgery is and should always be the last resort if drugs and other alternatives have failed to provide relief. Any type of surgery involves the danger of bleeding, infection, and pain. Surgery can restore joint functionality while also reducing discomfort. The various alternatives at the leading hospitals in Dubai include: 

Synovectomy: Procedure to remove the joint's inflammatory lining (synovium). 

Tendon repairs: This heals the tendons surrounding the joint that has loosened or ruptured due to inflammation. 

Joint fusion: If joint replacement is not an option, fusion may be used to stabilise or realign a joint. 

Total joint replacement: The injured joint is removed and replaced with a metal and plastic prosthesis. 

Synovectomy: Procedure to remove the joint's inflammatory lining (synovium). 

Tendon repairs: This heals the tendons surrounding the joint that has loosened or ruptured due to inflammation. 

Joint fusion. If joint replacement is not an option, fusion may be used to stabilise or realign a joint. 

Total joint replacement: The injured joint is removed and replaced with a metal and plastic prosthesis. 

Conclusion

If you are looking for the Best Rheumatoid Arthritis Treatment in Dubai, Patientexperts.co can help you connect with the right doctors. Contact us today to know more! 

[thangampmrc]

Understanding Common Digestive Disorders and Their Causes

The digestive system is an intricate network of organs tasked with processing food, extracting nutrients, and eliminating waste. When this intricate system encounters disruptions, it can lead to various digestive disorders that affect millions of people worldwide. These disorders can vary from causing mild discomfort to necessitating serious medical intervention.

 In this comprehensive guide, we will explore some of the most common digestive disorders, their causes, symptoms, diagnosis, and treatment options.

1. GASTROESOPHAGEAL REFLUX DISEASE (GERD)

Causes: GERD occurs when the lower oesophageal sphincter (LES) weakens or relaxes abnormally, allowing stomach acid to reflux into the oesophagus. This chronic condition can be aggravated by factors such as obesity, pregnancy, smoking, and certain foods.

Symptoms: Heartburn, regurgitation, chest pain, difficulty swallowing, and chronic cough are typical symptoms of GERD.

Diagnosis and Treatment: Diagnosis involves a combination of patient history, symptom assessment, and tests like endoscopy and pH monitoring. Treatment includes lifestyle changes (diet, weight management, smoking cessation) and medications (antacids, proton pump inhibitors) to reduce acid production and heal the oesophagus.

2. IRRITABLE BOWEL SYNDROME (IBS)

Causes: The exact cause of IBS is unknown, but factors like abnormal muscle contractions in the intestines, inflammation, and changes in gut bacteria may play a role. Triggers include specific foods, stress, and hormonal fluctuations.

Symptoms: Abdominal pain, cramping, bloating, gas, diarrhoea, and constipation are hallmark symptoms. Symptoms can range in severity and may vary over time.

Diagnosis and Treatment: Diagnosis involves excluding other conditions and evaluating symptom patterns. Treatment focuses on dietary changes (low FODMAP diet), stress management, medications (antispasmodics, fiber supplements), and lifestyle modifications.

3. PEPTIC ULCER DISEASE

Causes: Peptic ulcers are sores that develop on the lining of the stomach, small intestine, or oesophagus due to bacterial infection (H. pylori), prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), and excessive stomach acid production.

Symptoms: Burning stomach pain, bloating, nausea, vomiting, and bleeding are common symptoms. Severe ulcers can lead to complications like perforation or obstruction.

Diagnosis and Treatment: Diagnosis involves endoscopy, biopsy, and tests for H. pylori. Treatment involves antibiotics to eliminate H. pylori, medications to reduce stomach acid (such as proton pump inhibitors and H2 blockers), and lifestyle modifications.

4. INFLAMMATORY BOWEL DISEASE (IBD)

Causes: IBD includes Crohn’s disease and ulcerative colitis, both of which are autoimmune disorders marked by chronic inflammation of the digestive tract. Genetic predisposition, immune system malfunction, and environmental factors contribute to their development.

Symptoms: Abdominal pain, diarrhoea (often bloody), weight loss, fatigue, and complications like fistulas or strictures are typical symptoms.

Diagnosis and Treatment: Diagnosis involves a combination of imaging studies, endoscopy, biopsy, and clinical assessment. Treatment aims to reduce inflammation with medications (immune suppressants, biologics), manage symptoms, and maintain remission through lifestyle adjustments and sometimes surgery.

5. GALLSTONES

Causes: Gallstones are solidified deposits of bile that can develop in the gallbladder due to imbalances in bile composition, such as excess cholesterol, bilirubin, or insufficient bile salts. Risk factors include obesity, rapid weight loss, pregnancy, and genetics.

Symptoms: Intense abdominal pain (often after meals), nausea, vomiting, and jaundice are common symptoms. Gallstones can cause complications like inflammation of the gallbladder (cholecystitis) or blockage of the bile ducts.

Diagnosis and Treatment: Diagnosis involves imaging tests (ultrasound, CT scan). Treatment options include medications to dissolve stones (ursodeoxycholic acid), lithotripsy to break up stones, and surgical removal of the gallbladder (cholecystectomy).

6. CELIAC DISEASE

Causes: Celiac disease is an autoimmune disorder triggered by the ingestion of gluten in individuals who have a genetic predisposition. Gluten, a protein present in wheat, barley, and rye, initiates an immune response that damages the lining of the small intestine.

Symptoms: Digestive symptoms (abdominal pain, diarrhoea, bloating) along with fatigue, joint pain, skin rash (dermatitis herpetiformis), and neurological symptoms can occur. Some individuals may experience subtle or unusual symptoms.

Diagnosis and Treatment: Diagnosis involves blood tests (antibodies), endoscopy with biopsy, and genetic testing. Treatment requires strict adherence to a gluten-free diet to manage symptoms and prevent complications like malnutrition and osteoporosis.

CONCLUSION

Understanding common digestive disorders and their causes is essential for early detection, effective management, and an improved quality of life. If you experience persistent digestive symptoms, consult our specialists in the Gastroenterology Department. At Thangam Multispeciality Hospital, with over 25 years of service in Kerala, we provide the best healthcare services. Schedule an appointment with usfor an exceptional care. With advancements in medical science and proactive lifestyle choices, many digestive disorders can be effectively managed, enabling individuals to lead healthy and fulfilling lives. Stay informed, stay healthy!

[drmanishkumargupta]

Ulcerative Colitis: Explore Its Symptoms, Causes, and Treatments

Ulcerative Colitis (UC) is a chronic inflammatory condition of the colon that can significantly impact a person’s quality of life. At the Gastro, Liver & Endoscopy Center in Ghaziabad, under the expert guidance of Dr. Manish Gupta, patients are provided with comprehensive care to manage and treat this challenging condition. In this blog, we will delve into the symptoms, causes, and treatments for Ulcerative Colitis, and how Dr. Gupta and the team at our center are dedicated to providing top-notch care.

Understanding Ulcerative Colitis:

Ulcerative Colitis is a type of inflammatory bowel disease (IBD) that causes long-lasting inflammation and ulcers in the lining of the large intestine (colon) and rectum. It is characterized by periods of flare-ups and remissions. The condition can vary from mild to severe, and its impact can range from inconvenient to life-threatening.

Symptoms of Ulcerative Colitis:

The symptoms of Ulcerative Colitis can vary depending on the severity of the condition and the portion of the colon affected. Common symptoms include:

Abdominal Pain and Cramping: Patients often experience discomfort and pain in the abdomen due to inflammation and ulceration.

Diarrhea: Frequent, urgent bowel movements with blood or pus are common symptoms. This can lead to dehydration and nutrient deficiencies.

Rectal Bleeding: Blood in the stool is a key symptom and can be distressing.

Weight Loss: Due to malabsorption of nutrients and reduced appetite, significant weight loss can occur.

Fatigue: Chronic inflammation can lead to persistent tiredness and weakness.

Fever: Some patients may experience low-grade fevers during flare-ups.

Understanding these symptoms is crucial for early diagnosis and effective management of the disease. If you’re experiencing any of these symptoms, it’s essential to consult a specialist.

Causes of Ulcerative Colitis:

The exact cause of Ulcerative Colitis is not fully understood, but several factors are believed to contribute to its development:

Genetics: A family history of IBD may increase the risk of developing UC. Researchers are investigating genetic predispositions to better understand this link.

Immune System Dysfunction: UC may result from an abnormal immune response where the body attacks its own tissues, leading to inflammation in the colon.

Environmental Factors: Certain environmental triggers, such as diet, stress, or infections, might play a role in exacerbating the condition, though they are not considered primary causes.

While the exact cause remains elusive, identifying these potential factors can help in managing and mitigating the impact of the disease.

Diagnosis and Treatment:

Accurate diagnosis and appropriate treatment are crucial for managing Ulcerative Colitis effectively. At the Gastro, Liver & Endoscopy Center in Ghaziabad, Dr. Manish Gupta employs a range of diagnostic tools and treatments to provide the best care.

1. Diagnostic Approaches:

Colonoscopy: This procedure allows direct visualization of the colon and rectum to assess inflammation, ulcers, and other abnormalities. As the Best Colonoscopy Centre in Noida & Ghaziabad, we offer state-of-the-art equipment and experienced professionals for accurate diagnosis.

Biopsy: During a colonoscopy, a small tissue sample may be taken to examine for specific markers of UC.

Blood Tests: These tests can help detect anemia, inflammation markers, and other abnormalities.

Imaging Tests: Sometimes, imaging techniques like CT scans are used to assess the extent of inflammation.

2. Treatment Options:

Medications: The primary treatment involves medications to reduce inflammation and manage symptoms. These include:

Aminosalicylates: To reduce inflammation.

Corticosteroids: For severe inflammation and flare-ups.

Immunomodulators: To suppress the immune response.

Biologics: Target specific proteins involved in inflammation.

Dietary Changes: While no specific diet cures UC, certain dietary adjustments can help manage symptoms. Patients are advised to avoid foods that trigger symptoms and to maintain a balanced diet to prevent nutritional deficiencies.

Surgery: In cases where medications and other treatments are ineffective, surgery may be necessary. This often involves removing the affected part of the colon and can lead to significant improvement in symptoms.

Lifestyle Adjustments: Stress management and regular exercise can also play a role in managing UC. Dr. Gupta often recommends incorporating these into a comprehensive treatment plan.

Why Choose Dr. Manish Gupta at Gastro, Liver & Endoscopy Center?:

As the Best Gastroenterologist in Ghaziabad, Dr. Manish Gupta brings a wealth of experience and expertise to the management of Ulcerative Colitis. His patient-centered approach ensures that each individual receives personalized care tailored to their specific needs. The Gastro, Liver & Endoscopy Center is equipped with advanced diagnostic tools and treatment options, making it a leading choice for patients in Ghaziabad and surrounding areas.

If you are experiencing symptoms of Ulcerative Colitis or need a comprehensive evaluation, contact the Gastro, Liver & Endoscopy Center to schedule a consultation with Dr. Gupta. Our team is dedicated to providing compassionate care and effective treatment strategies to help you manage this condition and improve your quality of life.

By understanding the symptoms, causes, and treatment options for Ulcerative Colitis, you can take proactive steps toward better health. Dr. Manish Gupta at the Gastro, Liver & Endoscopy Center in Ghaziabad is here to support you every step of the way.