#pubme

[queerographies]

[A piedi nudi sui sassi][Angela Castorina][Arianna Dongu]

"A piedi nudi sui sassi" di Angela Castorina e Arianna Dongu racconta l'incontro tra Alice e Amelia, unite dall'amore in un mondo ostile. La storia affronta temi delicati come l'amore, l'amicizia e la discriminazione LGBTQ+, ispirata dall'autobiografia de

Un’amicizia che diventa amore: la loro storia ti toccherà il cuore Titolo: A piedi nudi sui sassiScritto da: Angela Castorina e Arianna DonguEdito da: PubMeAnno: 2024Pagine: 203ISBN: 9791254585733 La trama di A piedi nudi sui sassi di Angela Castorina e Arianna Dongu È il caso o il destino a far incontrare Alice e Amelia? Le ragazze si conoscono a una convention della serie televisiva fantasy…

[sognareleggiesogna]

REVIEW PARTY: Tutto il buio che ho di Margherita Rossi

Cari Sognatori, Rosanna ha letto il romanzo di narrativa LGBT+ di Margherita Rossi e pubblicato dalla Over the Rainbow – PubMe !!! Genere: narrativa LGBT+  Data di pubblicazione 22 marzo 2024 Ebook / Cartaceo Affiliati Amazon  A un occhio esterno, Emma ha tutto ciò che si potrebbe desiderare: una buona famiglia, un mucchio di soldi, una carriera assicurata e un fidanzato perfetto. Eppure, a Emma…

[salvadorbonaparte]

* blows a kiss to my computer * for JSTOR

[gomzdrawfr]

Bear with me here I am going to word vomit of an AU I thought of (and I literally just woke up) Idk if I have the time to write, draw or even animate this bUT

A ghostprice au where Price goes blind

Here’s a scene I had in my head, imagine a blackout panel, with a typewriting sound effect in the back that reads:

Patient Information: Johnathan Price, birth date, weight, height, number, address (something along those lines which are meant to hint this is a beginning of a medical record)

and then white blurry speech bubbles appearing from left and right

“What?”

You voiced out, or rather, Price voiced out (you are in Price’s POV)

All the speech bubbles seized, and for a moment it’s just darkness and much quieter whispers

“…Laswell?”

“John, you’re up, easy now”

He hears her from his left, but still there’s total darkness, and he furrows his brows, hands slowly reaching up to pat his face, or scratch it— there’s nothing on his skin, so he’s not being blindfolded, and there’s no sac or bag covering his head— but there is layers of something covering his eyes that he tries to pull off, managing to peek through a bit, he thinks he’s opening his eyes but—

Still black

“…?”

And then we cut to a shot of Ghost’s face, eyes wide with realization that Price can’t see anymore.

The last panel reads:

“Diagnosis: Traumatic Optic Neuropathy” (aka vision loss”

- end of scene

More rambles:

Thinking about maybe from a mission an IED went off before anyone could react— well technically Price reacted first by pulling Ghost away, which resulted in direct exposure to the blast, followed by a concussion

Ghost immediately got on his feet and dragged Price away while also making sure all units were still available, he looks down and he sees laceration and red

Well okay I haven’t figure out the clinical part but Im thinking maybe some blood pools around the corner of Price’s eyes (if, say, the laceration cut across his eyelids), it wouldn’t be as dramatic to the point where there’s blood trickling down his eyes per see cuz Idk if I plan to make the shrapnel penetrate into the cornea (in this case it would be extremely severe cause of trauma, I shall have some mercy on him)

Maybe amongst the panic he saw how Price’s left eye slowly turned red (internal bleeding) and all his alarms went off and quickly get medical on it

Of course he was praying that it wasn’t as serious, maybe it was superficial and maybe his eyes were playing tricks on him cuz it was dark and the hallway had red lamp all over

Also i just realized this is prob quite inaccurately portrayed bcuz the bandages that covers the eyes are usually tightly sealed, and that his action of ripping them off is prrrobbaaably not good since infections and increasing the pressure around his eyes are just going to make this worse (like reopening sutures or whatnot) but i think it could work (shhh ✨fiction science✨)

But nope, Price is blind, and that automatically puts him unfit for service and Ghost knows that this isn’t going to go well for the man

We always joked around saying Price is old but imagine if he’s mid 30s, prime in his years and definitely still had a lot of kick in him— only to be forcefully ripped away from it

The devastation, the angst, the anger, the unfairness of it all, the never ending cycle of guilt from both Ghost and Price

DO U FEEL IT?!

Anyways *ah hem* if you’ve read this far and would be interested to develop this yourself whether with fic or art go ahead! I sure as hell won’t be able to bring out the sheer desperation and agony from this sort of au or story so yeah XD

[queenoflostwhispers]

Whenever I am looking for a specific article sometimes I am reminded the best part of doing any research...the title

glorious.

[my-autism-adhd-blog]

Hi everyone,

Since its epilepsy awareness month, I wanted to share an interesting study about its connection to autism. According to the abstract:

Autism is more common in people with epilepsy, approximately 20%, and epilepsy is more common in people with autism with reported rates of approximately 20%.

However, these figures are likely to be affected by the current broader criteria for autism spectrum disorder (ASD), which have contributed to an increased prevalence of autism, with the result that the rate for ASD in epilepsy is likely to be higher and the figure for epilepsy in ASD is likely to be lower.

Some evidence suggests that there are two peaks of epilepsy onset in autism, in infancy and adolescence. The rate of autism in epilepsy is much higher in those with intellectual disability. In conditions such as the Landau–Kleffner syndrome and nonconvulsive status epilepticus, the epilepsy itself may present with autistic features. There is no plausible mechanism for autism causing epilepsy, however.

The co-occurrence of autism and epilepsy is almost certainly the result of underlying factors predisposing to both conditions, including both genetic and environmental factors. Conditions such as attention deficit hyperactivity disorder, anxiety and sleep disorders are common in both epilepsy and autism. Epilepsy is generally not a contraindication to treating these conditions with suitable medication, but it is important to take account of relevant drug interactions.

One of the greatest challenges in autism is to determine why early childhood regression occurs in perhaps 25%. Further research should focus on finding the cause for such regression. Whether epilepsy plays a role in the regression of a subgroup of children with autism who lose skills remains to be determined.

I put the text in paragraphs so it’s easier to read and not jumbled up. I hope you all find this informative and interesting. 💜

[3liza]

[pandemic-info]

The figures from this are amazing:

...to avoid inhaling the sanitizer vapor, the volunteers placed hands on one side of the body and turned the head to the opposite side, as shown on the right in Figure 2. The second practice was named as the vapor‐avoiding hand disinfection.

[snarp]

Can we use an LLM to identify potential signs of badly-designed biomedical research yet. Like feed one a selection of studies flagged as "good methodology, clearly described" "bad methodology, clearly described" and "methodology not clearly described", and it dumps out a list of phrases/structures that can be used to autoflag the study as "potentially fucked". And you know it's starting to work if some of the phrases are just names of researchers who fucking suck.

[lifeislikeawavewhorisesupanddown]

[queerographies]

[Leader][Aurora Pinelli]

Ora che tutto ciò che ha sempre creduto di essere è stato messo in discussione, Simone dovrà ripartire da zero per capire chi è e prendersi ciò che vuole davvero.

La squadra di basket del liceo classico Ludovico Ariosto vanta, da tre anni a questa parte, il capitano più determinato e carismatico che abbia mai avuto: Simone Vitale. Bello da mozzare il fiato e consapevole di esserlo, Simone è convinto che non esista niente che possa mettere in discussione la sua virilità, ed è pronto a dire lo stesso dei suoi compagni. Invece deve ricredersi quando,…

[sognareleggiesogna]

REVIEW PARTY: Memorie di un Fantasma di Stefania De Prai Sidoretti

Cari Sognatori, Michy, la nostra blogger, ha letto il Paranormal /Fantasy scritto da Stefania del Prai Sidoretti e pubblicato dalla  Pubme, Collana Milos !!! GENERE: Paramormal / Fantasy DATA D’USCITA: 31 Gennaio 2024 EBOOK / CARTACEO Affiliati Amazon TRAMA A Roma, alla Porta del Popolo, il 21 aprile 1513, la vita di un giovane garzone di fornaio giunge a una brusca fine a causa di un…

[liuisi]

im at the point where im considering saying something i KNOW is false in this lab report and just taking the points off instead of spending more time doing research

[idliketochill]

human.(?)

[wovenstarlight]

surprising amount of time put into translation is spent not translating

[jcsmicasereports]

Myxoid liposarcoma of the spermatic cord: A rare entity by Emmanuel E. Sadava in Journal of Clinical Case Reports Medical Images and Health Sciences

Abstract

An 81-year-old man consulted at our hospital for evaluation of a long-established left inguinal mass. The patient denied experiencing pain, food intolerance, constipation or urinary tract symptoms in the past. A physical examination revealed a 15x10cm painless mass in the left inguinal region, distinct from the testicle, with no palpable changes during Valsalva´s maneuver. Magnetic resonance imaging (MRI) showed a 79mm heterogeneous lesion of the spermatic cord which projected itself through the inguinal canal into the scrotal sac, displacing the testis inferiorly. Laboratory testings were negative for testicular tumor markers such as α fetoprotein and human chorionic gonadotropin-β. A surgical resection of the inguinal tumor with an “en-bloc” inguinal orchiectomy was performed. The inguinal floor was repaired with a modified Bassini technique without the use of a mesh. The histopathological report confirmed findings were consistent with a myoxid liposarcoma. No further treatment was indicated and the patient continued follow-up with bi-annual MRIs. 18 months later, the patient continues with no signs of recurrence.

Key words: liposarcoma, liposarcoma of the spermatic chord, abdominal wall surgery, inguinal mass.

Introduction

Sarcomas constitute a heterogeneous group of rare solid tumors of mesenchymal cell origin. Collectively they account for approximately 1% of all adult malignancies with an annual incidence of 2.5 cases per million population[1]. In adults, the most common soft tissue sarcomas are liposarcomas. Overall, they account for approximately 17% of all soft tissue sarcomas. Most cases arise from de novo, therefore, the development from a preexisting benign lipoma is rare. Liposarcomas usually appear as a slowly enlarging, painless mass in a middle-aged person with a slightly higher incidence in men.

These tumors are classified in three main biologic forms: 1) well-differentiated liposarcoma; 2) myxoid and/or round cell; and 3) pleomorphic. The latter being a rare high-grade with a high recurrence rate and poor prognosis. The well-differentiated and myxoid types have favorable prognoses. However these tumors locally recur after incomplete excision[2].

The anatomic site of the primary disease represents an important prognostic factor, influencing treatment and outcome. Extremities (43%), the trunk (10%), visceral (19%), retroperitoneum (15%), or head and neck (9%) are the most common primary sites. Scrotal location is relatively rare, accounting for 3.6% of all liposarcomas. The origin of intra scrotal liposarcomas include the spermatic cord (76%), testicular tunic (20%), and the epididymis (4%).

Case Report

An 81-year-old man with a medical history of follicular cutaneous lymphoma and an open left hemi-colectomy for colon cancer consulted at our hospital for evaluation of a long-established left inguinal mass. The patient denied experiencing pain, food intolerance, constipation or urinary tract symptoms in the past. A physical examination revealed a 15x10cm painless mass in the left inguinal region, distinct from the testicle, with no palpable changes during Valsalva´s maneuver. Magnetic resonance imaging (MRI) showed a 79mm heterogeneous lesion of the spermatic cord which projected itself through the inguinal canal into the scrotal sac, displacing the testis inferiorly. Laboratory testings were negative for testicular tumor markers such as α fetoprotein and human chorionic gonadotropin-β. Ultrasound-guided biopsies of the mass were requested and their histopathology analysis revealed myxoid stroma with fusocelular proliferation.

A radical resection was suggested but, a week prior to the surgical procedure, the patient was diagnosed with COVID infection during which he intercurred with myocardial infarction and ischemic stroke. He underwent a double coronary angioplasty with drug-eluted stents and required anticoagulation and antiplatelet therapy posteriorly. The case was discussed at a multidisciplinary meeting and a conservative management of the inguinal tumor was decided. The patient was reassessed 12 month later with a new MRI, which showed the inguinal mass increased in size (99mm) compared to the previous study, and a computed tomography (CT) with no evidence of metastatic disease. A surgical resection of the inguinal tumor with an “en-bloc” inguinal orchiectomywas performed. The inguinal floor was repaired with a modified Bassini technique without the use of a mesh. The patient had an uneventful recovery and was discharged from the hospital on postoperative day two.

The histopathological report confirmed a 130x120x120mm low-grade fibro myxoid neoplasm. The surgical margins were negative. Immunohistochemistry showed strong reactivity for S100 and vimentin, whereas SOX10, desmin, CD34 and estrogen receptors were negative. These findings were consistent with a myoxid liposarcoma. No further treatment was indicated and the patient continued follow-up with bi-annual MRIs. 18 months later, the patient continues with no signs of recurrence.

Discussion

Liposarcomas invade through local extension and rarely invade through the lymphatic route, making regional lymph node dissection lose its value and having no impact on survival. Nevertheless, high-grade subtypes are associated with high rates of recurrence and hematogenous spread; lungs, liver and peritoneum being the most common sites of metastasis.  Surgical resection (with appropriate negative margins: >1cm) is the standard primary treatment in most patients with stromal cell sarcomas. Complete tumor resection is the primary prognostic factor for local recurrence, and liposarcomas are not the exception. Performing an “en-bloc” resection involving a high orchiectomy (including the surrounding tissue) is important to obtain negative margins [1].

Local recurrence rates for sarcomas, including liposarcomas of the spermatic cord, have been reported to be as high as 30-50%. Because of this, and despite the patient’s disease-free status, long term follow-up remains a crucial step in the detection of recurrences that might still be potentially curable. Current controversy arises on the use of adjuvant chemotherapy or radiotherapy. Being a rare and infrequent entity makes it hard for a single institution to accumulate enough cases to perform prospective randomized controlled trials. Extrapolated data from retrospective analyses support the use of adjuvant radiation on selected high-risk situations (tumor recurrence, high-grade tumors or residual disease). Concerning the role of chemotherapy, the use of adjuvant chemotherapy remains controversial and there is no definitive role in the management of localized liposarcomas[3].

In conclusion, myxoid liposarcomas of the spermatic cord are infrequent entities. As most soft tissue sarcomas, they have an indolent course and should be considered as a differential diagnosis of inguinal masses with no palpable changes during Valsalva´s maneuver. Complete surgical resection with high-orchidectomy “en-bloc” is encouraged.