#nih

[mostlysignssomeportents]

Trumpism’s healthcare fracture-lines

If you'd like an essay-formatted version of this post to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:

https://pluralistic.net/2024/12/20/clinical-trial-by-ordeal/#spoiled-his-brand-new-rattle

There was never any question as to whether Trump would implement Project 2025, the 900-page brick of terrifying and unhinged policy prescriptions edited by the Heritage Foundation. He would not implement it, because he could not implement it. No one could. It's impossible.

This isn't a statement about constitutional limits on executive authority or the realpolitik of getting bizarre and stupid policies past judges or through a hair-thin Congressional majority. This is a statement about the incoherence of Project 2025 itself. You probably haven't read it. Few have. Realistically, few people are going to read a 900-page group work of neofeudalist fanfic shit out by the most esoteric Fedsoc weirdos the world has ever seen.

But one person who did read Project 2025 was the leftist historian Rick Perlstein, who was the first person to really dig into what a fucking mess that thing is:

https://pluralistic.net/2024/07/14/fracture-lines/#disassembly-manual

Perlstein's excellent analysis doesn't claim that Project 2025's authors aren't sincere in their intentions to wreak great harm upon the nation and its people; rather, his point is that Project 2025 is filled with contradictory, mutually exclusive proposals written by people who fundamentally disagree with one another, and who each have enough power within the Trump coalition that all of thier proposals have to be included in a document like this:

https://prospect.org/politics/2024-07-10-project-2025-republican-presidencies-tradition/

Project 2025 isn't just a guide to the masturbatory fantasies of the worst people in American politics – far more importantly, it is a detailed map of the fracture lines in the GOP coalition, the places where it is liable to split and shatter. This is an important point if you want to do more about Trumpism than run around feeling miserable and scared. If you want to fight, Project 2025 is a guide to the weak spots where an attack will do the most damage.

Perlstein's insight continues to be borne out as the Trump regime makes ready to take power. In a new story for KFF News, Stephanie Armour and Julie Rovner describe the irreconcilable differences among Trump's picks for the country's top public health authorities:

https://kffhealthnews.org/news/article/trump-rfk-kennedy-health-hhs-fda-cdc-vaccines-covid-weldon/

The brain-worm-infected-elephant in the room is, of course, RFK Jr, who has been announced as Trump's head of Health and Human Services. RFK Jr is a notorious antivaxer, chairman of Children’s Health Defense, a notorious anti-vaccine group. Kennedy's view is shared by Trump's chosen CDC boss, Dave Weldon, a physician who has repeated the dangerous lie that vaccinations cause autism. Mehmet "Dr Oz" Oz, the TV "physician" Trump wants to put in charge of Medicare/Medicaid, calls vaccines "oversold" and advocates for treating covid with hydroxychloroquine, another thoroughly debunked hoax:

https://www.usatoday.com/story/news/health/2024/12/17/hydroxychloroquine-study-covid-19-retracted-trump/77051671007/

However, other top Trump public health picks emphatically support vaccines. Marty Makary is Trump's choice for FDA commissioner; he's a Johns Hopkins trained surgeon who says vaccines "save lives" (but he peddles the lethal, unscientific hoax that childhood vaccines should be "spread out"). Jay Bhattacharya, the economist/MD whom Trump wants to put in charge of the NIH, supports vaccines (he is also one of the country's leading proponents of the eugenicist idea of accepting the mass death of elderly, sick and disabled people rather than imposing quarantines during epidemics). Then there's Janette Nesheiwat, whom Trump has asked to serve as the nation's surgeon general; she calls vaccines "a gift from God."

Like "Bidenism," Trumpism is a fragile coalition of people who thoroughly and irreconcilably disagree with one another. During the Biden administration, this resulted in self-inflicted injuries like appointing the brilliant trustbuster Lina Khan to run the FTC, but also appointing the pro-monopoly corporate lawyer Jacqueline Scott Corley to a lifetime seat as a federal judge, from which perch she ruled against Khan's no-brainer suit to block the Microsoft-Activision merger:

https://www.thebignewsletter.com/p/judge-rules-for-microsoft-mergers

The Trump coalition is even broader than the Biden coalition. That's how he won the 2024 election. But that also means that Trumpism is more fractious and off-balance, and hence will be easier to disrupt, because it is riven by people in senior positions who hate one another and are actively working for each others' political demise.

The Trump coalition is a coalition of *cranks*. I'm using "crank" here in a technical, non-pejorative sense. I am a crank, after all. A crank is someone who is overwhelmingly passionate about a single issue, whose uncrossable bright lines are not broadly shared. Cranks can be right or they can be wrong, but we're hard to be in coalition with, because we are uncompromisingly passionate about things that other people largely don't even notice, let alone care about. You can be a crank whose single issue is eliminating water fluoridation, even though this is very, very stupid and dangerous:

https://yourlocalepidemiologist.substack.com/p/the-fluoride-debate

Or you can be a crank about digital rights, a subject that, for decades, was viewed as by turns either unserious or as a sneaky way of shilling for Big Tech (thankfully, that's changing):

https://pluralistic.net/2024/06/18/greetings-fellow-pirates/#arrrrrrrrrr

Cranks make hard coalition partners. Trump's cranks are cranked up about different things - vaccines, culture war trans panics, eugenics - and are total normies about other things. The eugenicist MD/economist who wants to "let 'er rip" rather than engage in nonpharmaceutical pandemic interventions is gonna be horrified by total abortion bans and antivax. These cranks are on a collision course with one another.

This is on prominent display in these public health appointments, and we're very likely about to get a test of the cohesiveness and capability of the second Trump administration, thanks to bird flu. Now that bird flu has infected humans in multiple US states, there is every chance that we will have to confront a public health emergency in the coming weeks. If that happens, the Trump public health divisions over masking, quarantine and (especially) vaccines (Kennedy called the covid vaccine the "deadliest" ever made, without any evidence) will become the most important issue in the country, under constant and pitiless scrutiny, and criticism.

Trump's public health shambles is by no means unique. The lesson of Project 2025 is that the entire Trump project is one factional squabble away from collapse at all times.

[reasonsforhope]

"The Biden Administration last week [early December, 2023] announced it would be seizing patents for drugs and drug manufacturing procedures developed using government money.

A draft of the new law, seen by Reuters, said that the government will consider various factors including whether a medical situation is leading to increased prices of the drug at any given time, or whether only a small section of Americans can afford it.

The new executive order is the first exercise in what is called “march-in-rights” which allows relevant government agencies to redistribute patents if they were generated under government funding. The NIH has long maintained march-in-rights, but previous directors have been unwilling to use them, fearing consequences.

“We’ll make it clear that when drug companies won’t sell taxpayer funded drugs at reasonable prices, we will be prepared to allow other companies to provide those drugs for less,” White House adviser Lael Brainard said on a press call.

But just how much taxpayer money is going toward funding drugs? A research paper from the Insitute for New Economic Thought showed that “NIH funding contributed to research associated with every new drug approved from 2010-2019, totaling $230 billion.”

The authors of the paper continue, writing “NIH funding also produced 22 thousand patents, which provided marketing exclusivity for 27 (8.6%) of the drugs approved [between] 2010-2019.”

How we do drug discovery and production in America has a number of fundamental flaws that have created problems in the health service industry.

It costs billions of dollars and sometimes as many as 5 to 10 years to bring a drug to market in the US, which means that only companies with massive financial muscle can do so with any regularity, and that smaller, more innovative companies can’t compete with these pharma giants.

This also means that if a company can’t recoup that loss, a single failed drug can result in massive disruptions to business. To protect themselves, pharmaceutical companies establish piles of patents on drugs and drug manufacturing procedures. Especially if the drug in question treats a rare or obscure disease, these patents essentially ensure the company has monoselective pricing regimes.

However, if a company can convince the NIH that a particular drug should be considered a public health priority, they can be almost entirely funded by the government, as the research paper showed.

Some market participants, in this case the famous billionaire investor Mark Cuban, have attempted to remedy the issue of drug costs in America by manufacturing generic versions of patented drugs sold for common diseases."

-via Good News Network, December 11, 2023

[justinspoliticalcorner]

Anna Merlan at Mother Jones:

At an event late last week in Arizona, anti-vaccine activist and Donald Trump transition team member Robert F. Kennedy Jr. said he’d fire and replace 600 people from the National Institutes of Health on “day one” of a second Trump term. The NIH is one of the public health agencies Kennedy loathes the most—and despite still lacking any defined role in a new administration, he’s clearly relishing the opportunity to promise retribution against them.  In comments that were first reported by ABC News, Kennedy declared, “We need to act fast, and we want to have those people in place on January 20, so that on January 21, 600 people are going to walk into offices at NIH and 600 people are going to leave.”  Kennedy, a long standing opponent of vaccines, has consistently been critical of the NIH, the Centers for Disease Control, and other federal agencies that are part of the basic infrastructure of public health. His The Real Anthony Fauci attacked Fauci, a former NIH director, at book length, albeit with what one physician reviewer called “many errors and gross misrepresentations.”

The remarks offering some concrete details about Kennedy’s Trump-aligned and so-called “Make America Healthy Again” agenda came during an onstage interview at an entrepreneurship event in Scottsdale, which included discussions of Kennedy’s workout routine and his relationship with the once and future president.

[...]

(Experts believe that autism was underdiagnosed until recent decades; the earliest prevalence weren’t conducted until the 1960s and ‘70s. Autistic adults have a range of abilities and autistic self-advocates have said that Kennedy uses offensive and ableist language to talk about autism: rather than “full blown,” public health experts would generally say “profound autism.” Kennedy also still uses the term “Aspergers,” an outdated phrase referencing a scientist who worked with Nazis during the Holocaust.)

This anti-public health bozo plans to fire 600 NIH workers.

[dosesofcommonsense]

[hellsitegenetics]

I just know that if the NIH website is being slow that it was your fault. Thank you for your service. Please get off I need to finish my Bio homework I'm begging you please please please

String identified: t tat t t g tat t a at. Ta c. a gt t ' ggg a a a

Closest match: Warburgia ugandensis isolate CL-2023a chromosome 7 Common name: Ugandan Greenheart

(image source)

[truth4ourfreedom]

ARE VACCINES CAUSING CANCERS IN ALL OF US?

"Judy Mikovits, PhD is a biochemist and molecular biologist with more than 33 years of experience. Internationally known, a veritable “rock star” of the scientific world, she served as the director of the lab of Antiviral Drug Mechanisms at the National Cancer Institute before directing the Cancer Biology program at EpiGenX Pharmaceuticals. She later developed the first neuroimmune institute. Her early work focused on cancer and HIV, her latest on Chronic Fatigue Syndrome and autism. She has published more than 50 peer-reviewed articles."

In 2011, she made the discovery that destroyed her career. She found that at least 30% of our vaccines are contaminated with gammaretroviruses. Not only is this contamination associated with autism and chronic fatigue syndrome, it is also associated with Parkinson’s, Lou Gehrig’s disease, and Alzheimer’s.

The retroviruses contaminating vaccines originate from mice used for research. Dr. Mikovits asks, “How many new retroviruses have we created through all the mouse research, the vaccine research, gene therapy research? More importantly, how many new diseases have we created?”

“When they destroyed all of our work, and discredited everything I or Frank Ruscetti had ever published, and arranged for the publication of my mug shot in Science, the NIH very deliberately sent the message to researchers everywhere about what would happen to any honest scientist who dared ask those important questions.”

[gwydionmisha]

This will kill so many people if they dismantle the US Public health system and pandemic response infrastructure as planned.

[queenoflostwhispers]

Whenever I am looking for a specific article sometimes I am reminded the best part of doing any research...the title

glorious.

[awesomecooperlove]

💉🦠💉

[pandemic-info]

[RFK] laid out his vision for a Kennedy presidency, which would include telling the National Institutes of Health to take “a break” from studying infectious diseases, like Covid-19 and measles, and pivoting the agency to the study of chronic diseases, like diabetes and obesity. Kennedy has suggested without evidence that researchers and pharmaceutical companies are driven by profit to neglect such chronic conditions and invest in ineffective and even harmful treatments; he includes vaccines among them.

“I’m gonna say to NIH scientists, God bless you all,” Kennedy said. “Thank you for public service. We’re going to give infectious disease a break for about eight years.”

—

Uh huh, ok. And I suppose viruses will conveniently give people a break. 🙄

I apologize to those following for helpful info — this isn’t it. 

But I’m saving this specifically for when someone inevitably says, “I don’t pay attention to news. What’s going on? It can’t be that bad. Is something happening to you personally? ” etc.

I don’t know what more you want. Nobody’s making this shit up. These direct quotes have been coming straight from all these horses mouths for years. They are explicitly telling everyone what they want to do and they are being given the power to do it, helped along by those who voted for them and those who stood by and said nothing at all.

[thebookishwallflower]

I want to make a post to inform people about the current situation with the bird flu (/avian flu/H5N1) outbreaks.

I don't want to cause panic but do want to spread information.

This is especially important if you live in an area that has a news system you don't trust to give accurate, timely, or honest news about something like a possible new pandemic, use your own judgement.

If that applies it is going to be very important to make sure you stay informed and follow these H5N1 outbreaks yourself and know how to best protect yourself.

I am no expert, but I do know a good bit about disease and influenza in particular, and have been following the H5N1 outbreaks as they've been happening, so under the cut I'm going to do my best to inform everyone I can.

Please stay safe, stay informed, and spread information, not germs.

What's bird flu and why do I care? (What's bird flu and why do I care?)

Avian flu and bird flu mean the same thing, an influenza virus that (primarily) infects birds. H5N1 denotes a specific strain of avian influenza. H5N1 can spillover (when a pathogen spreads from it's normal host organism to a new host organism) from animals to humans.

How could I get H5N1? (How could I get H5N1?)

Human to human transmission has not been observed yet (12/1/24) during this current outbreak. You can get this from contact with wild birds, especially water fowl, domestic birds, cattle, pigs, horses, dogs, and bats. It is also possible to get from raw (unpasteurized) milk and undercooked meat from infected animals.

What's the big deal then? (What's the big deal then?)

The common flu is not very pathogenic. How pathogenic something is determines how sick something makes the host, something that is highly pathogenic can cause severe disease. H5N1 is considered a HPAI, Highly Pathogenic Avian Influenza.

H5N1 is also a Type A influenza virus, most known Type A influenza viruses can infect birds. There is one Type A human flu in circulation at the moment, however it isn't very prevalent.

"IAV poses a significant risk of zoonotic infection, host switch, and the generation of pandemic viruses. IAVs can infect humans and a variety of animals, such as pigs, horses, marine mammals, cats, dogs, and birds (S1)."

IAV - Influenza A Viruses | Zoonotic infection - when an infectious disease of a non-human host infects a human host | Host switch - when a cross-species transmission of a pathogen can lead to successful, stable, and continuous infections

Every species the flu infects, the more strains that pop up under a sub-type IAV, the possibility for recombination increases. "Recombination occurs when at least two viral genomes [or strains] co-infect the same host cell and exchange genetic segments (S2)."

The flu is pretty good at recombination, when given the chance. It is also really good at mutating, and fast. If there were to be a recombination event and a new strain evolved (this would be called an antigenic shift) that was highly pathogenic, highly infectious (good at spreading, which H5N1 is), that could then infect humans and cause human-to-human transmission we might have a pandemic on our hands. This has not shown signs of happening during this outbreak*, this is what to look out for.

This (a recombination event) is what caused the 1918 pandemic during WW1. This pandemic killed an estimated 50 to 100 million people in 1918, in a world with a population of around 2 billion. 7.1 million died of COVID 19, as of 11/9/24 (S3), from a population of around 8 billion.

We know more, we are prepared, it's not guaranteed to happen, and it's not guaranteed to be as bad. But the possibilities are endless and it's extremely important to be prepared and stay informed.

So what do I do? (So what do I do?)

Again, stay informed, and that might mean checking independent news sources, the CDC website, and more, to keep yourself updated, especially if you know your local news won't do it for you. You should also familiarize yourself with the symptoms of influenza, if you have it, stay home.

Keep yourself safe, we had a pandemic already, you know the drill. Cover your nose and mouth when sneezing/coughing, wash your hands, sanitize your hands, and get your flu shot. And, in addition, avoid contact with wild birds, poultry, pigs, and cattle if you can.

In the event that this gets worse, social distancing is very important, being outdoors, wearing a mask, and all the stuff above, you can shed the virus for around a week before you start feeling bad. Keep yourself safe and don't infect anyone else.

If that doesn't sound like it'll do much, I promise you it does. Those are all classified NPI's (non-pharmaceutical interventions) and even epidemiologists were shocked at their impact and importance during the COVID-19 pandemic. They did work, and they were incredibly effective—as long as they were carried out.

I don't want to cause panic or worry anyone, but that is how information ends of suppressed. I want to make everyone aware of what we might face so that we can fight it and be strong and stay safe.

If anyone has any questions, wants any clarification, any corrections, or wants to know some good places to learn more about this stuff please don't hesitate to contact me (@'s, dm's, or asks), I will answer as best I can.

Here's the CDC's page covering the H5 bird flu current situation.

S1 - https://pmc.ncbi.nlm.nih.gov/articles/PMC5578040/

S2 - https://pmc.ncbi.nlm.nih.gov/articles/PMC7106159/

S3 - https://data.who.int/dashboards/covid19/deaths?n=c

*with the exception of this coverage (as a possibility): https://www.theguardian.com/world/2024/nov/19/bird-flu-cases-mutation-canada

[mostlysignssomeportents]

Uncle Sam paid to develop a cancer drug and now one guy will get to charge whatever he wants for it

Today (Oct 19), I'm in Charleston, WV to give the 41st annual McCreight Lecture in the Humanities. Tomorrow (Oct 20), I'm at Charleston's Taylor Books from 12h-14h.

The argument for pharma patents: making new medicines is expensive, and medicines are how we save ourselves from cancer and other diseases. Therefore, we will award government-backed monopolies – patents – to pharma companies so they will have an incentive to invest their shareholders' capital in research.

There's plenty wrong with this argument. For one thing, pharma companies use their monopoly winnings to sell drugs, not invent drugs. For every dollar pharma spends on research, it spends three dollars on marketing:

https://www.bu.edu/sph/files/2015/05/Pharmaceutical-Marketing-and-Research-Spending-APHA-21-Oct-01.pdf

And that "R&D" isn't what you're thinking of, either. Most R&D spending goes to "evergreening" – coming up with minor variations on existing drugs in a bid to extend those patents for years or decades:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680578/

Evergreening got a lot of attention recently when John Green rained down righteous fire upon Johnson & Johnson for their sneaky tricks to prevent poor people from accessing affordable TB meds, prompting this excellent explainer from the Arm and A Leg Podcast:

https://armandalegshow.com/episode/john-green-part-1/

Another thing those monopoly profits are useful for: "pay for delay," where pharma companies bribe generic manufacturers not to make cheap versions of drugs whose patents have expired. Sure, it's illegal, but that doesn't stop 'em:

https://www.ftc.gov/news-events/topics/competition-enforcement/pay-delay

But it's their money, right? If they want to spend it on bribes or evergreening or marketing, at least some of that money is going into drugs that'll keep you and the people you love from enduring unimaginable pain or dying slowly and hard. Surely that warrants a patent.

Let's say it does. But what about when a pharma company gets a patent on a life-saving drug that the public paid to develop, test and refine? Publicly funded work is presumptively in the public domain, from NASA R&D to the photos that park rangers shoot of our national parks. The public pays to produce this work, so it should belong to the public, right?

That was the deal – until Congress passed the Bayh-Dole Act in 1980. Under Bayh-Dole, government-funded inventions are given away – to for-profit corporations, who get to charge us whatever they want to access the things we paid to make. The basis for this is a racist hoax called "The Tragedy Of the Commons," written by the eugenicist white supremacist Garrett Hardin and published by Science in 1968:

https://memex.craphound.com/2019/10/01/the-tragedy-of-the-commons-how-ecofascism-was-smuggled-into-mainstream-thought/

Hardin invented an imaginary history in which "commons" – things owned and shared by a community – are inevitably overrun by selfish assholes, a fact that prompts nice people to also overrun these commons, so as to get some value out of them before they are gobbled up by people who read Garrett Hardin essays.

Hardin asserted this as a historical fact, but he cited no instances in which it happened. But when the Nobel-winning Elinor Ostrom actually went and looked at how commons are managed, she found that they are robust and stable over long time periods, and are a supremely efficient way of managing resources:

https://pluralistic.net/2023/05/04/analytical-democratic-theory/#epistocratic-delusions

The reason Hardin invented an imaginary history of tragic commons was to justify enclosure: moving things that the public owned and used freely into private ownership. Or, to put it more bluntly, Hardin invented a pseudoscientific justification for giving away parks, roads and schools to rich people and letting them charge us to use them.

To arrive at this fantasy, Hardin deployed one of the most important analytical tools of modern economics: introspection. As Ely Devons put it: "If economists wished to study the horse, they wouldn’t go and look at horses. They’d sit in their studies and say to themselves, ‘What would I do if I were a horse?’"

https://pluralistic.net/2022/10/27/economism/#what-would-i-do-if-i-were-a-horse

Hardin's hoax swept from the fringes to the center and became received wisdom – so much so that by 1980, Senators Birch Bayh and Bob Dole were able to pass a law that gave away publicly funded medicine to private firms, because otherwise these inventions would be "overgrazed" by greedy people, denying the public access to livesaving drugs.

On September 21, the NIH quietly published an announcement of one of these pharmaceutical transfers, buried in a list of 31 patent assignments in the Federal Register:

https://public-inspection.federalregister.gov/2023-20487.pdf

The transfer in question is a patent for using T-cell receptors (TCRs) to treat solid tumors from HPV, one of the only patents for treating solid tumors with TCRs. The beneficiary of this transfer is Scarlet TCR, a Delaware company with no website or SEC filings and ownership shrouded in mystery:

https://www.bizapedia.com/de/scarlet-tcr-inc.html

One person who pays attention to this sort of thing is James Love, co-founder of Knowledge Ecology International, a nonprofit that has worked for decades for access to medicines. Love sleuthed out at least one person behind Scarlet TCR: Christian Hinrichs, a researcher at Rutgers who used to work at the NIH's National Cancer Institute:

https://www.nih.gov/research-training/lasker-clinical-research-scholars/tenured-former-scholars

Love presumes Hinrichs is the owner of Scarlet TCR, but neither the NIH nor Scarlet TCR nor Hinrichs will confirm it. Hinrichs was one of the publicly-funded researchers who worked on the new TCR therapy, for which he received a salary.

This new drug was paid for out of the public purse. The basic R&D – salaries for Hinrichs and his collaborators, as well as funding for their facilities – came out of NIH grants. So did the funding for the initial Phase I trial, and the ongoing large Phase II trial.

As David Dayen writes in The American Prospect, the proposed patent transfer will make Hinrichs a very wealthy man (Love calls it "generational wealth"):

https://prospect.org/health/2023-10-18-nih-how-to-become-billionaire-program/

This wealth will come by charging us – the public – to access a drug that we paid to produce. The public took all the risks to develop this drug, and Hinrichs stands to become a billionaire by reaping the rewards – rewards that will come by extracting fortunes from terrified people who don't want to die from tumors that are eating them alive.

The transfer of this patent is indefensible. The government isn't even waiting until the Phase II trials are complete to hand over our commonly owned science.

But there's still time. The NIH is about to get a new director, Monica Bertagnolli – Hinrichs's former boss – who will need to go before the Senate Health, Education, Labor and Pensions Committee for confirmation. Love is hoping that the confirmation hearing will present an opportunity to question Bertagnolli about the transfer – specifically, why the drug isn't being nonexclusively licensed to lots of drug companies who will have to compete to sell the cheapest possible version.

If you'd like an essay-formatted version of this post to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:

https://pluralistic.net/2023/10/19/solid-tumors/#t-cell-receptors

My next novel is The Lost Cause, a hopeful novel of the climate emergency. Amazon won't sell the audiobook, so I made my own and I'm pre-selling it on Kickstarter!

[diablo1776]

RFK Jr

[thefreethoughtprojectcom]

The Fauci 🐭 is laughing all the way to the bank…

🔥 Fuel Our Work: https://bit.ly/TFTPSubs 🎙 TFTP Podcast: https://bit.ly/TFTPPodcast

TheFreeThoughtProject #TFTP

[dosesofcommonsense]

We can’t forget about this bitch. Fauci lied, people died - true. This lady had a hand in the killings, too. She deserves a noose right next to her colleague Fauci.

[cbirt]

The All of Us Research Program, with its ambitious objective of creating a diverse cohort of one million volunteers and making their data available for research, has enormous potential for revealing new information about human health and illness. Researchers have discovered more than 275 million previously unreported genetic variants, identified from data shared by nearly 250,000 participants of the National Institutes of Health’s All of Us Research Program. However, underlying this transformational movement is a complicated network of approaches for data gathering, processing, and access. This blog post explores the unique characteristics, potential impact, and bright future of genetic medicine of the program’s groundbreaking data release.

One of the main objectives of research on human health is to completely discover genetic diversity and record its role in health and illness, together with environmental and lifestyle influences. A major problem that has plagued the field of human genetics for decades is the under-representation of diverse perspectives in large-scale genomics studies. This biased viewpoint may have slowed the development of personalized medicine for all patients by restricting our understanding of how genetic variations impact health and sickness across groups. To close this gap, the All of Us Research Program, a groundbreaking initiative in the US, plans to make the largest and most diverse genome collection accessible to the general population.

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