#psychiatric medicine

[dorianbrightmusic]

New Antipsychotic FDA Approval – Cobenfy

Cobenfy (xanomeline/trospium chloride) has just been approved for schizophrenia treatment in the US. This is huge. It's the first antipsychotic in decades to not target dopamine directly. It's got a much, much better side-effect profile, and it might work for negative and cognitive symptoms.

FOR MORE READING – news report/patient-centred plain language overview: See here.

FOR MORE READING – scientific evidence report: See here (note: the drug is referred to as 'KarXT' in this report).

I couldn't be happier right now. People with psychosis go through so, so much trying to find medications that are both useful and tolerable, and psychiatry has historically neglected psychotic people's needs so, so awfully. (Not to mention how little there is that actually helps with anything other than positive symptoms.) So I'm really, really hoping that with the proof that we can, in fact, make antipsychotics that aren't based on the same old pharmacological things we've tried before. Cobenfy is a muscarinic agonist/antagonist in fixed combination – and it also indirectly regulates dopamine and glutamate. And given that we know both dopamine and NMDA are probably involved in schizophrenia somehow – AND that treating things to do with either is hard – this is so, so, so exciting.

This isn't to say Cobenfy doesn't have side-effects (the most common ones being nausea, constipation, dyspepsia, vomiting, hypertension, dry mouth, and tachycardia. We also know that there is a small risk of extrapyramidal symptoms, and that prolactin-related side-effects do happen, unfortunately). We don't know much about how it affects folks in the long-term, or much about the long-term tardive dyskinesia risk. But even so, it's progress compared to some of the worse antipsychotic side-effects.

Moreover, there is a possibility it might be useful for negative and cognitive symptoms. Holy crap.

I'm really really really excited. I hope this is the start of a shift in psychiatry towards better standards of patient-centred care for psychosis. Y'all have deserved better for far too long – here's hoping this is the start of more ethical, effective treatment.

[golmac]

Bright Stars Burn Out Fast

RIP page that lived one day, 11/25/2012-11/26/2012 (I love vintage psych med advertisements)

[ruindunburnit]

When I eventually pivot my video essays from House of Night to Death Note, I will finally tackle what I call the Glass Cell Theory, which the TV Drama made most clear:

Light only acts the way he does through the Yotsuba Arc and the Near Arc because of his solitary confinement. And in fact he is a perfect case for why we should not be doing that.

[angelnumber27]

Psychiatrists should directly at least even just briefly explain side effects instead of just asking symptoms and being like okay so you’re depressed? Let’s try *enter antidepressant* and boom you’re done. I know prescriptions almost always come with informational papers but I really truly doubt that most people read them. I honestly just feel it’s wrong and very careless to not disclose side effects to a patient and discuss those things with the patient before prescribing a medication.

[transingthoseformers]

Did you know in IDWG1 mnemosurgery/shadowplay is based on the lobotomy?

I'm right on this

This isn't from the wiki or Word of God or anything this is just something I can see with my eyes and make the connection

[automaticresponse]

INVADING SOMEONE'S PERSONAL HOME LIKE CRIMINALS HAVE DONE AT BRAD GEIGER'S ON WHITETAIL

[pathcend]

More great content from REV Med [instagram]

[kkoct-ik]

secondhand trauma is so fucked up because you have these horrible doom feelings and you dont even know why. youve been told the world is scary and you believed it and it was never something you made your own mind up about. its just part of life. and how do you argue with parts of life

[dumbsofsuperficialtextonlysearch]

Alien invaders socially engineering society so that discussion of or belief in advanced technology or aliens is viewed as signs of a psychiatric medical condition and a doctor can have an individual accused of having such a condition committed against their will to a psychiatric hospital and locked up there and drugged against their will without the requirement of any sort of trial or review prior.

[omenfailure]

I have this neat angsty Miquella/Mohg sketch/draft that I like the idea of but I hate the composition. I also wanna do some Trina/Mohg hurt/comfort with Trina lulling Mohg to eternal sleep and comforting him as the spell breaks and he's bursting with confusion

[gynandromorph]

Why does narrator's juncture use the word anamnesic instead of mnesic?

That's why--

[sophieinwonderland]

Oh wow, we didn't even know the ICD-11 is the standard. Another case of morally clouded Americans, damn. Of course they want their vague conclusions to be the correct one instead of what's accepted as the international standard.

Definitely!

If you want more information about the ICD, a good place to look for a comparison is the source you would expect to be the most biased against it... the APA.

This article actually suggests that ICD will eventually replace the DSM for diagnoses, leaving the DSM as a useful textbook for mental disorders, but no longer a separate diagnostic system.

The DSM isn't useless, and it is the main book used for diagnosis in the US and Canada at the moment, but it really is a book made for and by one country, and its days as the primary diagnostic guidebook, even in the countries that use it, are probably numbered.

[vulturesawake]

"Your mental illness is actually just a product of living under capitalism! You don't need those drugs they call 'medicine'!" Glad that's your experience. I'm legitimately batshit crazy though

[science-lover33]

Understanding Borderline Personality Disorder and the Role of Lamotrigine in Treatment

Borderline Personality Disorder (BPD) is a complex mental health condition characterized by emotional dysregulation, unstable relationships, impulsivity, and an unstable sense of self. Research into the underlying causes of BPD suggests a combination of genetic predisposition, neurobiological factors, and environmental influences. BPD is challenging to diagnose and treat due to its intricate nature, but one potential avenue of treatment that has garnered attention is the use of the medication lamotrigine.

Lamotrigine is an anticonvulsant medication primarily used to treat epilepsy, but it has also shown promise in addressing mood disorders, including BPD. This medication works by modulating the activity of glutamate, an excitatory neurotransmitter in the brain. Glutamate has been implicated in the pathophysiology of BPD, particularly in relation to emotional dysregulation and impulsive behaviors. Lamotrigine's mechanism of action involves stabilizing glutamate transmission, potentially leading to improved emotional stability and reduced impulsivity in individuals with BPD.

Research on the efficacy of lamotrigine in treating BPD is ongoing, but several studies have provided insights into its potential benefits. A randomized controlled trial by Elmslie et al. (2010) found that lamotrigine reduced emotional dysregulation and impulsivity in individuals with BPD. Furthermore, Nock et al. (2012) conducted a study indicating that lamotrigine might help alleviate self-injurious behaviors frequently associated with BPD. However, it's essential to note that the response to lamotrigine can vary among individuals, and its use should be carefully considered in conjunction with other therapeutic approaches.

While lamotrigine holds promise as a potential treatment for BPD, it's crucial to approach its use with caution. Consulting a mental health professional is vital to determine the appropriate course of treatment for individuals with BPD. The complexity of the disorder and the variability in treatment responses highlight the need for personalized and comprehensive approaches that may involve psychotherapy, medication, and support networks.

Sources:

Elmslie, J. L., Porter, R. J., Joyce, P. R., & Wells, J. E. (2010). Lamotrigine in Borderline Personality Disorder: A Randomized, Double-Blind, Placebo-Controlled Study. *The Journal of Clinical Psychiatry, 71*(6), 716-721.

Nock, M. K., Mendes, W. B., & Bogdan, R. (2012). A Preliminary Investigation of the Relationship Between Self-Injurious Behavior and Suicidal Behavior in Adolescents. *The Journal of Nervous and Mental Disease, 200*(10), 828-833.

Note: This information is for educational purposes only and should not be considered a substitute for professional medical advice. Always consult a qualified healthcare provider for personalized guidance and treatment options.

[emilemily]

I’m pulling myself off of all my psychiatric meds one by one and it has been hard, but I’m already feeling the positive effects. I was on an antipsychotic called Rexultifor the last year and successfully cold turkey’d it. Took my last one a month ago.

Now I’m pulling myself off of Trintellix, which is my antidepressant. I’ve gained a lot of weight on it and I’m just not happy with myself. Why am I even on so many meds? My doctor said that after she’s had me on an antipsychotic for a year, she actually doesn’t think I’m bipolar and instead thinks I just have extensive trauma.

Thanks I guess?

Anyway, today is my first day skipping my Trintellix. I’ve spent the last month in hellacious anti psychotic withdrawal, so anything this throws at me will feel like a cakewalk in comparison.

I’ll be staying on my Vyvanse, Guanfacine and Buspar. The Guanfacine works as a heart med for my POTS while also evening out the negative parts of being on a stimulant.

After coming off this anti depressant I will be coming off of gabapentin. That I will need to taper. I tried last summer to come off of it and almost offed myself as a result. I went catatonic and just laid on Stephen’s lap, rocking my body and humming to stop the terrible thoughts I was having.

I didn’t taper it though, so that was my issue.

I’m going to free myself from the shackles of all these medications. I’m 30 years old and I want to enjoy it. I want to feel everything deeply again instead of feeling this fuzzy numb feeling 24/7. I’d rather feel everything and cry than walk around this world letting time pass me by because I feel apathyx1000.

My medication journey started in rehab in 2020. I hadn’t taken meds since I was a child taking stimulants for my adhd. I was put on a cocktail of things and gained an insane amount of weight when all I needed was some fucking therapy and help addressing the death of my father.

Gonna set it all straight now and undo what I thought was just my new norm. It doesn’t have to be.

Here’s to lots of withdrawals coming my way, ha.

Hoping for strength.

[healingdryad]

Schizophrenia is a pointless diagnosis. Everything that should be treated by a provider is neurological, the rest we call a free mind.

Medblrs, what do you think?