#proteins and peptides

[mindblowingscience]

What puts the electronic pep in peptides? A folded structure, according to a new study in the Proceedings of the National Academy of Sciences. Electron transport, the energy-generating process inside living cells that enables photosynthesis and respiration, is enhanced in peptides with a collapsed, folded structure. Interdisciplinary researchers at the Beckman Institute for Advanced Science and Technology combined single-molecule experiments, molecular dynamics simulations and quantum mechanics to validate their findings.

Continue Reading.

[miss-biophys]

New publication out!

We were curious what happens with the lipid membrane if proteins are inside. As a model of membrane proteins we use transmembrane peptides with neutral and positive charge. The charges turn out to be quite crucial in the peptides influence on the lipids.

publication link: https://doi.org/10.1016/j.colsurfb.2024.113765…

All transmembrane peptides hinder mobility of lipids around. The positive charges in the peptide make this hindering a long range influence.

The membrane with the positive peptides then has heterogeneities in the lipid mobility. This hampers free rearrangement of lipids and leads to lower ability to seal ruptures. You can see below how the membrane stays fragmented after indentations with AFM (atomic force microscope), which is basically a very tiny tip that scans the surface of the membrane for images and can also push through it to test mechanical stability.

For comparison this is how it looks like with a membrane without any peptides. The mebrane seals the ruptures induced by the AFM tip and recovers its round shape. The same happens if we have a neutral, non-charged, peptide.

With this work we highlight the importance of including charges of proteins and peptides in membrane model studies.

And last but not least...

This is the very first time I am the last corresponding author of a publication. I am immensely proud on myself!

[boutique-nouri]

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[shinybulbasaur]

what if I reverse engineer a post that can get protein blasted into one of my peptides. yes it's cheating but consider. it would be so cool if I could pull it off

[nasirsellusa]

Vital Proteins Collagen Peptides Powder with Hyaluronic Acid and Vitamin C, Unflavored, 20 oz

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[peptide-peddler]

[One moment as I appraise this...]

N-[AVERAGEPERSONEATS3SPIDERSAYEARFACTOIDACTUALYJUSTSTATISTICALERRORAVERAGEPERSONEATS0SPIDERSPERYEARSPIDERSGEORGWHOLIVESINCAVEEATSOVER10000EACHDAYISANOUTLIERADNSHOULDNOTHAVEBEENCOUNTED]-C

Closest match: N-glu-arg-ser-asp-glu-arg-pro-val-glu-arg-ser-gly-glu-arg-ser-asp-glu-arg-pro-asp-glu-arg-ser-asp-glu-arg-pro-asp-glu-arg-ser-asp-glu-arg-ser-asp-glu-arg-ser-asp-glu-arg-pro-asp-glu-arg-ser-asp-glu-C (6.828 kDa - Common frog, Rana temporaria)

[Well, if Spiders Georg was any creature on this planet, they were gonna be a frog.]

[Those folks can EAT, and spiders are definitely on their menu.]

APPRAISAL: 3,818.86 ATP

“average person eats 3 spiders a year” factoid actualy just statistical error. average person eats 0 spiders per year. Spiders Georg, who lives in cave & eats over 10,000 each day, is an outlier adn should not have been counted

[atomytlaxcala2024]

¡Peina tu cabello con facilidad como si hubiera sido en un tratamiento de peluquería! La gama intensiva de cabello de proteína Atomy está infundida con una rica y potente proteína que restaura rápidamente la estructura de proteína interna de tu cabello, ¡y le trae de vuelta a la vida! Nuestra gama de cuidado del cabello intensivo en proteínas funciona como una clínica de proteínas honr salon que repone tu cabello desde el núcleo con nuestro propio código CMC e ingredientes patentados.

Código CMC (Proteína, Aminoácido, Péptido y Betaína) e ingredientes patentados (AQUATECTORtm y MAGNOLIA-KIOLtm) infundidos en el champú y tratamiento para un alto cuidado y cuidado proteico. Efecto inmediato después del primer uso que ayudan a alisar tu cabello, ayuda a reparar puntas abiertas y fricción del cabello dándole más fuerza y brillo lo cual se ve saludable no solo desde la superficie sino desde las raíces ¡Toda mucha bondad en cada botella!

¡Obtén el mismo cuidado que recibirías en una peluquería!

[peptide-peddler]

[One moment as I appraise this...]

N-[APPARENTLYIFYOUFINDATAGGEDHORSESHOECRABANDREPORTITTOFISHANDWILDLIFETHEYLLSENDYOUACERTIFICATEWITHINFOABOUTYOURCRABANDAPEWTERHORSESHOECRABPINKEEPYOUREYESPEELEDPHOTOFROMTHENANTUCKETCONSERVATIONFOUNDATION]-C

Closest match: N-ile-thr-thr-his-arg-leu-ser-ala-ile-gln-his-ala-asn-trp-ile-ile-val-leu-asp-asp-gly-leu-val-ile-glu-glu-gly-thr-his-glu-asn-leu-leu-ser-glu-asn-C (4.683 kDa - Sporosarcina bacterium)

[It's always the strange little creatures of the world that are more important than you think.]

[Like this little sequence right here - without it, this customer wouldn't be able to pump ATP properly, and we can't be having that now can we?]

APPRAISAL: 2,332.93 ATP

Apparently if you find a tagged Horseshoe crab and report it to Fish and Wildlife they’ll send you a certificate with info about your crab AND a pewter horseshoe crab pin! Keep your eyes peeled 👀

(Photo from the Nantucket Conservation Foundation)

[peptide-peddler]

[One moment as I appraise this...]

N-[ACTUALLYALLFOSSILRECONSTRUCTIONSAREWRONGBECAUSEFLESHONLYEVOLVEDRECENTLYBEFORETHATITWASBONEWORLD]-C

Closest match: N-leu-phe-ala-leu-asp-cys-lys-tyr-phe-pro-ser-ser-ile-leu-met-glu-ala-gln-asn-asn-val-ser-ala-pro-leu-gly-val-gln-leu-leu-gln-leu-glu-trp-trp-val-asn-gly-asp-glu-cys-glu-cys-ser-glu-C (5.884 kDa - Lemon-scented gum tree, Corymbia citriodora)

[Lemon scented gum! Now that's a delightful species.]

[And what a nice lengthy sequence as well - almost makes up for the fact that it's just a hypothetical protein.]

[But hey, what's a few pieces of evidence between friends? Who knows, this might wind up big once someone gets around to finding it - no bones about it.]

APPRAISAL: 2,808.41 ATP

Actually all fossil reconstructions are wrong because flesh only evolved recently. Before that it was bone world

[oh-dear-so-queer]

In one, the two α-carbon atoms are cis to each other; in the other, they are trans to each other. The trans configuration is more favourable because, in the trans configuration, the α-carbon atoms with the bulky groups bonded to them are further from each other than they in cis configuration. Virtually all peptide bonds in naturally occurring proteins studied to date have the trans configuration.

"Chemistry" 2e - Blackman, A., Bottle, S., Schmid, S., Mocerino, M., Wille, U.

[healthysharpreviews]

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[ironchemlabs]

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[peptide-peddler]

[One moment as I appraise this...]

N-[GUYWHOISDEFINITELYNOTABOUTTOFALLINTOASURPRISEMIDDAYNAPWITHANAFTERMATHWORSETHANAHANGOVERITSEEMSLIKEAREALLYGOODIDEATOLAYINBEDANDGETCOZYUNDERTHEBLANKETASPARTOFMYPLANNOTTOFALLASLEEPIDONOTKNOWWHY]-C

Closest match: N-val-glu-arg-ile-thr-asn-pro-lys-gln-lys-ser-glu-ser-leu-ile-lys-glu-gly-ile-thr-pro-ser-glu-ser-leu-leu-tyr-gly-asn-ile-asp-gln-C (4.147 kDa - Ferroplasma acidiphilum, a bacterium that grows in acidic, iron-containing pyrite mines and consumes/oxidises ferrous iron for energy, releasing sulfuric acid as a waste product)

[Whuf, now this one's a tough customer if ever I saw one!]

[If I ate iron for lunch and had to deal with acid splashes every time I went to take a leak, I'd want to take a midday nap too.]

APPRAISAL: 2,073.24 ATP

guy who is definitely not about to fall into a surprise midday nap with an aftermath worse than a hangover: it seems like a really good idea to lay in bed and get cozy under the blanket as part of my plan not to fall asleep. I do not know why.

[this-is-my-main-i-follow-from]

Ham chemical breakdown through ripening and hydrolysis

ID: a flow chart. Dry cured ham, triglycerides, phospholipids, muscle & adipose tissues lipases, muscle phospholipases: free fatty acids. Short chain, (oxidation,) carbonyl compounds, volatile compounds, aroma. Proteins, muscle calpains, & cathepsins, peptides, muscle exopeptidases, free amino acids, strecker/maillard reaction, taste & aroma.

[millennialskin]

Collagen Craze: Exploring the Fountain of Youth for Millennial Skin

Photo by Merve on Pexels.com In the quest for eternal youth, one word consistently emerges as a beacon of hope for millennials seeking to preserve their skin’s vitality: collagen. This crucial protein, abundant in our bodies, is the architect behind firm, supple skin, acting as a crucial building block that keeps our complexions plump, elastic, and radiant. However, as we age, collagen…

[purivausa]

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