#pernicious anemia

[thebibliosphere]

Hi! Just wanted to tell you that I read one of your posts about pernicious anemia, and thought “well that sounds exactly like what my weird body issues ™️ have been like”, got my doctor to run tests, and it turns out my b12 was basically non-existent. Got medication fairly recently and am finally starting to feel better, and I just wanted to thank you so very much, I don’t think I would’ve thought about that possibly being the problem without you. Everyone just wrote it off as stress.

I'm so glad you're starting to feel better!

Unfortunately, pernicious anemia/low b12 is overlooked these days by a lot of doctors (it's less of a concern with our fortified diets and can often be masked by the high levels of folic acid that get added into cereal and flour) and is often mistaken for mood disorders or just "stress."

As a point of interest, after I was diagnosed, the hematologist who saved my life said that he thought it should be mandatory to test ALL patients with mental health issues for low b12 because just being even slightly low can severely affect mood stability.

So, y'know, it's been a while since I've posted about b12 deficiency, so for anyone new here, please include b12 checks in your annual blood workup. You never know what it might be affecting!

[little-pissbaby]

PSA: tangling or tying these up off the floor is how someone like me dies on the floor of a public bathroom. if you untangle/untie an emergency cord, make sure it's resting OVER any bars in the wall so that you don't impinge its range. ty ly 😚

[typically-divergent]

being stuck in a body that’s so full of pains i cannot explain is tiring like i have so many intense unexplainable aches that i’ll never be able to accurately convey in a way that’s understandable for someone who will most likely never experience these struggles

[mathsbian]

Had a shit day and I have to take so many fucking pills in the morning now that I have my iron and vitamin C again and am also taking a vitamin B complex to try and tide me over til I can work up the nerve to make a call about a refill. I hate being sick.

I also desperately need out of this fucking living room oh my god

Have a new journal though to try and cope better and two more supplements to add to my regimen that have shown promise in reducing inflammation in FM. Which means even more pills…

Send help

[outskirts-of-life]

we finally harvested my two girls , frani and miranda 🪴🪴

lately i've been working on selectively breeding Zkittlez to make an ultimate anti-seizure / anti-autoimmune-disease-pain medicine .

[giraffe-showbiz]

My B12 tanks so quickly what the heck. Like I inject once every three weeks but I might need to go back to my 2 week schedule. On the positive, I do feel really lucky that I have the ability to do the intramuscular injection myself and that I’m not too grossed out by needles

[joysofbraindamage]

In this video you will learn Dylan Rothbein’s genetics life story. In this comprehensive science and personal story video, viewers will explore the intricate genetics behind several medical conditions and phenomena. The video delves into the genetic underpinnings of Ehlers-Danlos Syndrome (EDS), a group of connective tissue disorders caused by mutations in specific genes. The video explores the biological links between EDS, intersex conditions, and gender dysphoria. It also covers ataxia, a neurological disorder characterized by loss of coordination, often linked to genetic mutations Pernicious anemia, an autoimmune condition preventing vitamin B12 absorption, is examined through its genetic causes. The video further explains the role of genetics in fetal development with ectodermal dysplasia, highlighting how genetic material from both parents shapes the growth and development of a fetus ectoderm. Additionally, the concept of gene overexpression is discussed, illustrating how increased gene activity can lead to various biological effects. Sources https://link.springer.com/article/10.1007/s10048-021-00656-3. Citations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806399/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237408/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503231/#:~:text=Ehlers–Danlos%20syndrome%20(EDS),become%20more%20severe%20in%20adulthood 

https://dusunenadamdergisi.org/storage/upload/pdfs/1587030915-en.pdf

To enrich the learning experience and add context, viewers are encouraged to watch related videos: "My Lyme Disease Story," https://youtu.be/-d-vjHaWCUE?si=PLRFN3hD9ZQppLDc which provides personal insights into Dylan's living with Lyme disease; "Behind Blind Eyes," https://youtu.be/NAka1rqGGHQ?si=L2J_8Jl7qxsjG65- offering perspectives on visual impairment; and "The Science of An Inconvenient Rainbow," https://youtu.be/0Sr8O_lF7og?si=n7eT9ImReHEzbzAK about the effects of Lupron medication.

[spartanmemesmedical]

Exploring the Root Causes of Vitamin B12 Deficiency: Understanding the Culprits Behind this Common Condition

Introduction: Vitamin B12, also known as cobalamin, plays a crucial role in various bodily functions, including nerve function, red blood cell production, and DNA synthesis. Despite its importance, many individuals suffer from vitamin B12 deficiency, which can lead to a range of health problems if left untreated. In this comprehensive guide, we’ll delve into the various factors that can cause a…

[timesofpharma]

Pernicious anemia

Pernicious anemia: Pathophysiology of pernicious anemia and it’s treatment. Meaning of Pernicious is very dangerous or harmful. The pernicious anemia also known as Addison’s anaemia occurs because of deficiency of hemoglobin in the red blood cells. Deficiency of hemoglobin is caused by deficiency of Vitamin B12. Vitamin B12 is responsible for formation of cell walls and protein synthesis.…

[medicaregate]

Pernicious Anemia | Causes, Symptoms, Diagnosis & Treatments

Pernicious anemia (PA) is an autoimmune condition with a multifactorial etiology that includes environmental and immunological factors.

It is the leading cause of cobalamin deficiency anemia globally.

The primary pathophysiological mechanism in pernicious anemia is decreased dietary B12 absorption due to IF deficiency.

Pernicious anemia is a complicated condition with an obvious autoimmune origin.

The anemia is megaloblastic and is caused by a deficiency of vitamin B12, which is secondary to intrinsic factor (IF) deficiency.

The clinical presentation is gradual, and patients typically exhibit symptoms of:-

Anemia with pallor.

Fatigue.

Lightheadedness.

Tachycardia and decreased mental concentration.

PA is diagnosed by the presence of megaloblastic anemia, low serum vitamin B12 levels, gastric atrophy, and the presence of antibodies to the gastric parietal cell, or IF.

Early detection and treatment of pernicious anemia now results in a normal, and usually uncomplicated, lifespan.

Delayed treatment allows the anemia and neurologic complications to worsen.

The clinical management of PA patients is divided into two parts: treatment of cobalamin deficiency and monitoring of iron deficiency onset.

There are different therapeutic recommendations for PA in terms of the dosage and administration of vitamin B12 replacement therapy.

Vitamin B12 must be administered parenterally, and patients typically receive an intramuscular injection of 1,000 g B12 every day or every other day during the first week of treatment.

Read more at: https://medicaregate.com/pernicious-anemia-causes-symptoms-diagnosis-and-treatments/

[hazamacore]

my next b12 jab aligns exactly with when my next assignments are due which is the worst timing imaginable and im already annoyed at the extensions i’ll have to ask for which will cut into my winter break like man im trying to make the most of and enjoy the subject i really like here can u cut it out

[allalrightagain]

My coworker who I have known for one (1) month: yeah it’s wild, my friend has all sorts of issues and is super deficient in b12. I mean, I only have to get shots maybe 5-6 times a year, but it’s like she’s just not absorbing it.

Me: *don’t say anything don’t say anything nobody needs a lecture if she’s having issues she can ask—*

Me: oh haha yeah I get b12 shots monthly. Actually—

[little-pissbaby]

this is gonna get TMI and it will get sad and whiny so please don't feel obligated to keep reading.

it takes so many steps to be alive. all of the things you do subconsciously suddenly become arduous tasks when you have to do them manually. things like eating, drinking, sleeping, breathing, using the bathroom, it's exhausting having to think about and consciously or manually do even just one of those things.

I was officially diagnosed with dysautonomia a few months ago, although I have been struggling with my symptoms for over a decade and I've been in treatment for several years. I was also diagnosed with a neurogenic bladder that same month. this means I have to catheterize myself 3-4 times a day every day for the rest of my life, or until I can get a suprapubic catheter placed.

Y'ALL. self-cathing is beyond exhausting. it's a little bit of a genuine workout, especially when you're morbidly obese like me. I hate that I've gotten really good at it and that it doesn't take me long at all now. I didn't want to get good at it, I didn't want to have to have this skillset. I already have to know how to draw up and give an IM injection, how to flush an IV, how to reduce dislocated joints in myself and others... I am TIRED.

I'm sure a colostomy is also in my near future. I have the same problems in my colon that I have in my bladder, only it's also complicated by endometriosis in the walls of my colon and rectum. they haven't been completely infiltrated yet, but if this IUD doesn't do its job, then I'm definitely gonna start losing organs and my mind.

at this point I'm out of words to explain why I'm so cosmically fatigued but if I tag every diagnosis/condition I have maybe y'all can sorta get an idea.

sorry for ranting. I have to go cath myself now.

at least I do it under the supervision of the best medical advisor ever <3 all she asks for in return are kisses, cuddles, and crunchies <3<3

[typically-divergent]

living in a body that’s always out to get you is debilitating. physically, mentally, it never ends. i’m so tired of being the cause of all of my own problems.

[chibeast]

I really wish I liked salad, or at least knew what else to consume to get the nutrients that are in salads!

[celepeace]

I think I might be a little sick in the head because I was thinking about that person who likes getting surgeries bc it's fun and I was like oooh that's so me. I love having medical things done to me. It's so cool and interesting. I love it when they stick monitors on me or use ultrasounds to look in my body. When I have a weird medical procedure/test coming up I tell people about it like it's an exciting activity. I look forward to it. If I didn't have vasovagal syncope from needles I'd be one of those people who watches when the nurse inserts the IV and I'd be all interested talking about it with them. That's not normal is it