#obviously it’s good

[batcavescolony]

Katniss is such an unreliable narrator. She says "Then something unexpected happens. At least, I don't expect it because I don't think of District 12 as a place that cares about me" girl you deliver strawberries to the Mayor, you hunt and trade for the district, when you fell at Prim being chosen someone caught you, when you went to Prim people parted for you, when you volunteered EVERYONE stopped. Idk how to tell you but I think you're a pillar of the community.

[shoomlah]

I have a feeling that beneath the little halo on your noble head There lies a thought or two the devil might be interested to know You're like the finish of a novel that I'll finally have to take to bed You fascinate me so

You Fascinate Me So, Blossom Dearie

[plounce]

people online talk so much about hating babies and kids but in "the meatspace" people LOVE babies. hang out with a baby and you will see so many people staring at you with big smiles and waving at you and going "that baby is SO cute" and generally being pleasant unprompted. the lady at the vietnamese place just now gave us like three extra soup spoons because my niece loves those spoons but kept dropping them on the floor and the lady kept giving us more with a massive smile on her face. on our walk today a bunch of construction guys waved and grinned at her the whole time we walked by, and when we passed by an elementary school a little girl said "your baby's really sweet!" babies are not balls of irritation and hatred they are beacons of joy and kindness actually and they bring out the best in strangers. whenever im out with her we have multiple positive interactions with strangers who are so happy to see her. or maybe it's just that my baby niece is the cutest most wonderful baby in the world :]

[v0idwraith]

quite frankly idgaf what Luigi Mangione’s politics are, he actually did something to make a change and that’s more than most people can say

[why-animals-do-the-thing]

hi! can i ask what's ur opinion on giving pets away? not necessarily because u can't afford to care for em anymore but maybe incompatibility of personalities or maybe lifestyles. is it wrong to give ur pet for adoption if u know someone who's better suited for keeping a pet, like emotionally?

This is going to be controversial, but I support making that choice.

There’s a lot of rhetoric lately around how it’s evil and unethical to rehome your pet if you don’t “need to.” And what that does is prioritize human ideology over the actual animal’s well-being.

Pets that aren’t a good match for your home or pets that aren’t really wanted anymore frequently have lower welfare! When caring for an animal becomes a burden or is forced, people end up resenting them, and that means the animal often doesn’t get all of its needs fulfilled. Even if you’re still feeding it and providing appropriate vet care, how likely are you to provide affection or enrichment to an animal you’re tired of being stuck with?

Lifestyle and personality really matter to making sure a pet is a good fit for a home. A dog that alert-barks at every leaf that moves is probably a bad fit for someone who has a chronic migraine syndrome, and they might not know that until the dog has been in the home for weeks and started to open up. A really feisty kitten that requires a ton of play might not do best in the home of someone older who wanted a quiet lap cat. And while you can you do your best to plan to find a compatible animal, you won’t always know ahead of time what issues might arise.

“Forever home” rhetoric is really, really popular and I think it’s very unfair to the animals it is supposed to support. It started with the backlash of seeing animals abandoned inappropriately, and has been heavily reinforced in the public mind because it’s so frequently used to drive fundraising and support for legislation. The whole “forever home” concept communicates to people that getting an animal is an immutable commitment and that if you can’t keep an animal, it is a personal moral failing. It frames human priorities (we think people who get rid of animals are Evil and Bad and should be shunned) as more important than actual welfare needs for individual animals (are they getting the care they need where they are).

Obviously, I don’t support people dumping animals or just getting fad pets they’ll discard immediately, but there’s so many alternate situations that can arise. Even if it’s just “they got a pet and didn’t know what caring for it would take and didn’t want to care for it so they brought it back, how awful��� like… okay, I’d like the person to have done more research before they got a pet, but isn’t it better that the animal now has a second chance to go to better home? Knowing what a commitment requires theoretically can be very different than having to actually follow through regularly, and I’d rather see someone maturely acknowledge that having an animal isn’t a good fit than keep it anyway!!

If animals being happy and with all their biological, veterinary, and social needs fulfilled is actually the goal, we need to prioritize their welfare over human opinion. I’d much rather see an animal rehomed responsibly to somewhere it will thrive and be welcomed than see people keep animals they can’t/don’t want to care for out of guilt or shame. 

[sodacowboy]

people are still liking my m*ximum r*de fanart??? bro???

[pangur-and-grim]

Belphie looks so handsome today

[andstuffsketches]

girl who lives in a cave

[bogkeep]

ok so i think that my favourite fantasy subgenre is The Inherent Tragedy Of Being Born Into Royalty. which mostly means that i like to read about gay princes but with some nuance

[chloesimaginationthings]

What if Mike and Jeremiah are the guards in FNAF 2..

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[jubshead]

So we’re in agreement that this is canon… right?

[aristoteliancomplacency]

Beans.

My partner and I have a running joke with a friend. Every time he goes on holiday we increase the quantity of beans in his flat.

The first time we bought ~30 cans of kidney beans and hid them around the house like some Easter egg hunt thing but with beans.

The Second time we bought ~6kg dried white beans and hid those in various places. Nearly every receptacle that could safely hold beans became the home of beans. My personal favourite was emptying an oat milk carton, very carefully washing and drying it, filling it with beans and then just putting it back among several other cartons.

He went on holiday again a couple of weeks ago. Obviously there is an expectation of bean-based shenanigans. And obviously we have to beat our previous efforts.

Our friend has (had) a mosaic on his wall of the famous Marilyn Monroe Pop-Art by Andy Warhol. He made the mosaic himself. Over the last couple of weeks we have spent hours and hours assembling a frame, drawing up a pattern and gridding out a 70 x 70 frame and gluing an untold amount of beans to it. I have spent over 21 hours gluing beans to a frames.

For the last couple of days I ended up going to bed at 5:00 am because I lost track of time whilst experimenting with which types of glue works best with different beans (I now have *opinions* on this, y’all). The day of our friend’s return we spent the morning and afternoon grouting the piece and wiping it down and wiping it down again and wiping it down again because grout is just like that. In the evening we went to install the mosaic, just a few hours before his return. Here’s a comparison between the original and our clearly superior replication, and the new piece installed in its rightful place.

[clementimetodie]

recently saw someone's "advice for your 30s" which included something like "never get on the floor without having an escape plan for getting back up" and um. if you are otherwise able bodied and having trouble getting up from the floor in your 30s. you are very unhealthy. yes, even, if not especially, for that age.

[maddie-grove]

As someone who’s living with a middle school social studies teacher, all the posts along the lines of “why did we never learn about this historical event in school” just make me go “because your teacher was supposed to cover all of US history in one year, and they didn’t get to the Revolutionary War until Halloween because they were urged to slow down the progression of the lessons because a more senior teacher was running behind, and they didn’t get to the Civil War until Valentine’s Day because the school kept scheduling every special event during social studies because there’s no end-of-grade testing for that subject, and they didn’t get to WWI until May because they were sick for a few days and the substitute couldn’t do much more than babysit, and now they’re having to do the entire Cold War in two days, so that’s why you didn’t hear about the lesbian inventor of the circus peanut. They would have loved to tell you about the lesbian inventor of the circus peanut!”

[fidgetspringer-art]

Boots on throats, as promised.