#obviously it’s good

[shoomlah]

I have a feeling that beneath the little halo on your noble head There lies a thought or two the devil might be interested to know You're like the finish of a novel that I'll finally have to take to bed You fascinate me so

You Fascinate Me So, Blossom Dearie

[sodacowboy]

people are still liking my m*ximum r*de fanart??? bro???

[pangur-and-grim]

Belphie looks so handsome today

[plounce]

people online talk so much about hating babies and kids but in "the meatspace" people LOVE babies. hang out with a baby and you will see so many people staring at you with big smiles and waving at you and going "that baby is SO cute" and generally being pleasant unprompted. the lady at the vietnamese place just now gave us like three extra soup spoons because my niece loves those spoons but kept dropping them on the floor and the lady kept giving us more with a massive smile on her face. on our walk today a bunch of construction guys waved and grinned at her the whole time we walked by, and when we passed by an elementary school a little girl said "your baby's really sweet!" babies are not balls of irritation and hatred they are beacons of joy and kindness actually and they bring out the best in strangers. whenever im out with her we have multiple positive interactions with strangers who are so happy to see her. or maybe it's just that my baby niece is the cutest most wonderful baby in the world :]

[chloesimaginationthings]

What if Mike and Jeremiah are the guards in FNAF 2..

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

--

Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[jubshead]

So we’re in agreement that this is canon… right?

[inkskinned]

probably time for this story i guess but when i was a kid there was a summer that my brother was really into making smoothies and milkshakes. part of this was that we didn't have AC and couldn't afford to run fans all day so it was kind of important to get good at making Cool Down Concoctions.

we also had a patch of mint, and he had two impressionable little sisters who had the attitude of "fuck it, might as well."

at one point, for fun, this 16 year old boy with a dream in his eye and scientific fervor in heart just wanted to see how far one could push the idea of "vanilla mint smoothie". how much vanilla extract and how much mint can go into a blender before it truly is inedible.

the answer is 3 cups of vanilla extract, 1/2 cup milk alternative, and about 50 sprigs (not leaves, whole spring) of mint. add ice and the courage of a child. idk, it was summer and we were bored.

the word i would use to describe the feeling of drinking it would maybe be "violent" or perhaps, like. "triangular." my nose felt pristine. inhaling following the first sip was like trying to sculpt a new face. i was ensconced in a mesh of horror. it was something beyond taste. for years after, i assumed those commercials that said "this is how it feels to chew five gum" were referencing the exact experience of this singular viscous smoothie.

what's worse is that we knew our mother would hate that we wasted so much vanilla extract. so we had to make it worth it. we had to actually finish the drink. it wasn't "wasting" it if we actually drank it, right? we huddled around outside in the blistering sun, gagging and passing around a single green potion, shivering with disgust. each sip was transcendent, but in a sort of non-euclidean way. i think this is where i lost my binary gender. it eroded certain parts of me in an acidic gut ecology collapse.

here's the thing about love and trust: the next day my brother made a different shake, and i drank it without complaint. it's been like 15 years. he's now a genuinely skilled cook. sometimes one of the three of us will fuck up in the kitchen or find something horrible or make a terrible smoothie mistake and then we pass it to each other, single potion bottle, and we say try it it's delicious. it always smells disgusting. and then, cerimonious, we drink it together. because that's what family does.

[some-kind-of-creature]

It wasn’t supposed to be a secret.

If you died while with the league, you will no longer be acknowledged to have existed, especially if you died during a mission. A disappointment will not be remembered.

The bats and birds don’t like speaking about the people they have lost, so they don’t. If someone ask about the dead, they will tell the person they don’t talk about that.

So how was Damian supposed to know that he should have told his father about his dead brother?

[aristoteliancomplacency]

Beans.

My partner and I have a running joke with a friend. Every time he goes on holiday we increase the quantity of beans in his flat.

The first time we bought ~30 cans of kidney beans and hid them around the house like some Easter egg hunt thing but with beans.

The Second time we bought ~6kg dried white beans and hid those in various places. Nearly every receptacle that could safely hold beans became the home of beans. My personal favourite was emptying an oat milk carton, very carefully washing and drying it, filling it with beans and then just putting it back among several other cartons.

He went on holiday again a couple of weeks ago. Obviously there is an expectation of bean-based shenanigans. And obviously we have to beat our previous efforts.

Our friend has (had) a mosaic on his wall of the famous Marilyn Monroe Pop-Art by Andy Warhol. He made the mosaic himself. Over the last couple of weeks we have spent hours and hours assembling a frame, drawing up a pattern and gridding out a 70 x 70 frame and gluing an untold amount of beans to it. I have spent over 21 hours gluing beans to a frames.

For the last couple of days I ended up going to bed at 5:00 am because I lost track of time whilst experimenting with which types of glue works best with different beans (I now have *opinions* on this, y’all). The day of our friend’s return we spent the morning and afternoon grouting the piece and wiping it down and wiping it down again and wiping it down again because grout is just like that. In the evening we went to install the mosaic, just a few hours before his return. Here’s a comparison between the original and our clearly superior replication, and the new piece installed in its rightful place.

[bewarethecircles]

Neil Gaiman: "in season 2 the fan-favorite angel/demon couple will fall in love, overcome great adversity, and eventually defy heaven and hell to run off together to the stars :)"

Fans: "cool! I can't wait, does Aziraphale confess first or does Crowley?'

Neil, holding Gabriel and Beelzebub figures and making them kiss: "Does who do what now?"

[clementimetodie]

recently saw someone's "advice for your 30s" which included something like "never get on the floor without having an escape plan for getting back up" and um. if you are otherwise able bodied and having trouble getting up from the floor in your 30s. you are very unhealthy. yes, even, if not especially, for that age.

[maddie-grove]

As someone who’s living with a middle school social studies teacher, all the posts along the lines of “why did we never learn about this historical event in school” just make me go “because your teacher was supposed to cover all of US history in one year, and they didn’t get to the Revolutionary War until Halloween because they were urged to slow down the progression of the lessons because a more senior teacher was running behind, and they didn’t get to the Civil War until Valentine’s Day because the school kept scheduling every special event during social studies because there’s no end-of-grade testing for that subject, and they didn’t get to WWI until May because they were sick for a few days and the substitute couldn’t do much more than babysit, and now they’re having to do the entire Cold War in two days, so that’s why you didn’t hear about the lesbian inventor of the circus peanut. They would have loved to tell you about the lesbian inventor of the circus peanut!”

[shorthistorian]

Kink isn’t shameful because of the weird sex stuff. That part’s rad. It’s shameful because it is technically improv. 

[quadrantadvisor]

Imagine if the GIW started gunning for Jason without the Batfam ever meeting Phantom. Like, Bruce has to figure out on his own that the guys in white suits with Lazarus guns are 1. a legitimate government agency, and 2. are perfectly within their rights to hunt Jason like an animal, because 3. there's secret government legislation that says that since Jason's body processes ectaplasm, he's classified as non-sapient and has no legal protections.

Bruce calling up Clark like

Bruce: I am currently in the process of breaking into a government facility in order to dismantle their operations.

Clark: Okay? Do you need... help?

Bruce: Yes.

Clark: Sure, I'll be right there.

Bruce: Not that kind of help. Oracle is sending you the files now. I'd like you and Ms. Lane to make these people wish they were never born.

Clark: [speed-reading the documents] Oh yeah, can do. This is truly disgusting. If the public is half as outraged as I am, we'll get this sorted as fast as the courts can manage.

So Clark Kent acts as a whistle-blower, the Justice League publicly condems the Anti-Ecto Acts as inhumane, the GIW is disbanded, and Batman gets pardoned for all of those crimes that he technically did by assaulting federal agents. And after all that gets sorted, some white haired kid pops up in the Watchtower like "haha thanks for that I really didn't want a war between Earth and the Infinite Realms" and the League are like "wait what"

[chloesimaginationthings]

FNAF Sun reviews Michael Afton’s art,,