#it looks super interesting!!

[ifwebefriends]

No but the way my jaw DROPPED when I saw that DANA TERRACE is working on the new Glitch show?!?!?!?!????????

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[choccy-milky]

@foundthatoldzeppelinshirt what did u do to me...what in the wattpad is this... i only planned to do a few doodles but then i kept getting more brainrotted and things got out of hand LMAOO (and ofc i HAD to draw hockey player seb at SOME POINT bc its my duty as a canadian citizen🫡🍁🍁 O CANADA!!!)

[lilybug-02]

Oh gosh, how many humans are there?!

Bug Fact: The Giant Malaysian Leaf Insect are mostly female and reproduce asexually. The first wild male of this species was not found until 1994! Pictures Below.

V2 First || Prev // Next

Volume 2 Masterpost

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A,B,C and E are all males, they have visible and functional wings. D is a female and has no wings. Photo Source and Research Paper with more photos

They even have separate sub-species that have different leaf decay!!

[artzee534]

"Where have I seen this before?"

The individual frames:

Bonus: concerned brothers

[frodo-a-gogo]

Let us be brutally honest with ourselves and with eachother for a moment. If he weren't obese you motherfuckers would be capable of percieving evrart claires sexy sexy moral ambiguity and complex charms

[spirk-trek]

really love that for the metron design they went with "androgynous angel dressed head to toe in glitter"

[rosalie-starfall]

The Not Ready For Prime Time Players

Saturday Night / Saturday Night Live October 11th 1975

[corn-cardigan]

I love how you always draw D'arce with the biggest bluest eyes ever ♡

ty!! I'm totally aware that in the game's art, her eyes are more greyish but I think the unsettling blue stare fit her disturbed aura

tosses some d'arce scribbles at yall

[motherwench]

jeanette lee, a brooklyn-born pool player nicknamed the “black widow” for her tendency to wear all black outfits and “lure [her] opponents to the table and eat them alive.” some of my favorite photos of her :)

her vogue article here. sports illustrated article here.

photo creds: 1 - drew endicott via vogue. 2. 3. 4.

[morganbritton132]

Eddie takes a break from his live-streamed jam session to get a drink out of the kitchen. He takes his audience with him.

He’s moseying on up from his studio when he pauses. He sees something off-screen that make his eyes go wide and a little panicked. Then he’s ducking down and darting on his tiptoes down the hall, all the while, whisper-shouting, “Steve. Steve! Where the hell are you? Steve!”

He finds Steve in their bedroom, tidying up their nightstands. Eddie barely acknowledge what he’s doing and doesn’t acknowledge his live stream at all like, “Steve! There’s a stranger in the living room!!”

Steve, casual: No, there’s not

Eddie: Yea, there is! There’s a man sitting on our couch!

Steve: Yeah. That’s Tommy

Eddie: That -that’s Tommy? Tommy H?

Eddie: Wow… he had a glow up

Steve: *gives Eddie the bitchiest look known to man*

[hairychestloversblog]

When he gives you that look 👀 ….. you know what has to be done 😈🥵👅

[confused-stars]

i'm rewatching s1 of Arcane, and i'm sure people have already written fics about this, but the soulmate au where you have your soulmate's first words to you tattooed on your skin is so funny for jayvik because

Jayce's first words to Viktor are "Science, I guess?" and i love that for them both

[firestorm09890]

Penny stardewvalley makes me so sad because she's SO sensitive to, like, basically everything you tell her (telling her that you can't stand children while two children are nearby is a pretty lousy move but -1500 friendship?? being a jerk to other characters' faces typically loses you about 50 points, and if you choose the option labeled "creepy" and ask Leah for a kiss in her 2 heart event she physically hits you and kicks you out of her house but that's only -100 friendship…) and so if you want to befriend her it's a whole lot of lying and tiptoeing around her feelings (2 hearts: George was right but saying that makes her feel bad. 6 hearts: her food sucks but even if you try to be polite about it she feels like a failure; only a bald-faced lie pleases her. 8 hearts: saying you don't want to be tied down with a family loses you a little bit of friendship and she's only happy if you say you want kids) and I can't help but think she's a product of her environment. She lives in a trailer with only her mother, who gets drunk every night and has something of a temper. Penny's like a skittish rescue animal who won’t even come out from hiding under something unless you leave her lots of treats

[mblue-art]

sans au sexyman polls doooodle

congrats to the kings<3 🫶🫶🫶

[avephelis]

just wanted to say it's really awesome seeing the positive reception to chunky mikey LOVE YOU ALL 🧡🧡