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#hepatitis- c causes
northgazaupdates · 5 months
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18 April 2024
Environmental engineer Dr. Tamer Al-Najjar describes the Hepatitis C outbreak in north Gaza, with which he himself and his family are afflicted. The following was entered into a machine translation software and as such is bound to have some flaws, but the main ideas are still clear. Dr. Al-Najjar’s condition continues to worsen, and he has asked for prayers for his recovery.
He writes,
Since it has become a personal and family guest, I would like to update the official description of hepatitis C, so that the world knows it in its realistic form!
Regardless of its symptoms that I will mention, its basic definition begins with its causes. It spread among us after six months of total war and complete annihilation against us, after the complete destruction of the infrastructure, including sewage and water, and after the spread of thousands of tons of solid waste and rubbish. sanitation in the streets, roads and holes resulting from the bombing that did not stop, and after the spread of sewage among people and under their feet everywhere, and preventing any civil effort from exercising its work in reducing these massive disasters and targeting crews, devices and equipment, and killing all ideas of progress regarding this matter. After the inhuman conditions we have been living through for months...
From here, we were all infected. From here, and because of the previous set of reasons, as a result of the continuous aggression, the barbaric war, and the prevention of the entry of the necessary capabilities and tools...we were infected with hepatitis and it spread among us. And it spread everywhere!
As for its symptoms, it is a very harsh condition that we go through, old and young, in which we experience all the symptoms of the terrifying world, high temperature, severe diarrhea, severe colic, nausea and profound fatigue, fatal vomiting, blocked appetite, a feeling of suffocation to a large extent, with complete isolation from the surroundings for fear of infection.. .
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covid-safer-hotties · 1 month
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They develop a mask that lights up when it detects the Coronavirus. It would signify great progress in case detection - Published Aug 5, 2024
Scientists at Harvard and the Massachusetts Institute of Technology are trying to apply the technology that worked to fight other diseases to this pandemic.
This invention could help stop the spread of COVID-19. A team of scientists from Harvard University and the Massachusetts Institute of Technology (MIT) develop a mask that glows when contaminated by the new coronavirus. It would greatly help in the fight against this global pandemic.
According to Business Insider, in 2014, the MIT bioengineering laboratory began to develop sensors to detect the Ebola virus when it underwent lyophilization (a dehydration process) on a piece of paper. This same technology was adapted to address the Zika virus outbreak.
Again, as part of their work on this subject, they’re conducting research to be able to help in the COVID-19 pandemic. In this case, they hope to create a mask that can produce a fluorescent color to identify the coronavirus. If successful, it would help complement current virus detection methods.
“As we open up our transit system, you could envision it being used in airports as we go through security, as we wait to get on a plane,” said Jim Collins, head of the MIT lab, in conversation with Business Insider.
“You or I could use it on the way to and from work. Hospitals could use it for patients as they come in or wait in the waiting room as a pre-screen of who’s infected” he added.
This could greatly facilitate the work of doctors in the midst of this pandemic. One of the peculiarities of this coronavirus, unlike previous outbreaks, is the lack of symptoms in patients that test positive, making contagion easier for those who think they’re healthy when in reality they’re just asymptomatic. Also, it would make the detection of cases much quicker.
For now, it’s just in the first phase – although expectations are very high. They hope to develop the detector’s design in a way in which the sensors can be embedded into any mask.
They hope to show in the coming weeks that this method works. “Once we’re in that stage, then it would be a matter setting up trials with individuals expected to be infected to see if it would work in a real-world setting,” Collins said.
It would just be a matter of adapting the sensors to this new coronavirus, since in 2018 this technology was able to detect the viruses that cause SARS, measles, influenza, hepatitis C, West Nile, in addition to other diseases.
“We initially did this on paper to create inexpensive paper-based diagnostics,” Collins said. “We’ve shown it can work on plastic, quartz, as well as cloth.”
The COVID-19 vaccine is expected to be part of a long process, which is still far from over. However, this mask could help lower the rate of contagion around the world.
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selfmedblves · 11 months
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Safe Snorting Guide
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Insufflation or snorting is a common means for administering drugs. However, snorting still comes with some risks that can be avoided with the proper precautions.
How Insufflation Works
When a drug is snorted up the nostril, it enters the bloodstream through blood vessels that line the nose. This means the effects of the drug will have an earlier onset than the oral route.
The Risks of Insufflation
While insufflation at first glance has less risks than other methods of consuming drugs, it still comes with its risks. If you are snorting drugs, please keep in mind that:
Snorting a drug can still result in overdose.
Regular snorting can damage your septum and cause a hole to form.
Using bills or keys can expose you to unnecessary germs
When snorting drugs, the skin in your nose can become damaged and lead to bleeding, when snorting equipment is shared, this can spread Hepatitis C.
Preparing Drugs for Snorting
Note: If you are snorting any drug that is a press, keep in mind that the pill weight will not be the same as the amount of drug in the pill. Get a good milligram scale to weigh your pill. Divide the weight of your press with the amount of drug in the press. That'll tell you how many milligrams of pill powder you'd have to snort to feel the affects of 1 gram of drugs.
Example, if you get a press that is 30mg of adderall, but the pill weighs 90mg, you'd have to snort 3mg of adderall to get the same effects of snorting 1mg of speed. If you plan on snorting 15mg of speed, you'd need to snort 45mg of adderall to get the same effects.
If you want to snort a drug that isn't already in its powder form, there are two main ways to crush drugs into a fine powder.
The first way can be done with a lighter and a bag/piece of paper. Place the drugs in your bag or in between a folded piece of paper. Hold your bag/paper on a solid surface and hit the drugs with your lighter until it is a fine powder.
The second method is to use a pill crusher to crush your drugs into a fine powder. It is recommended that you clean your pill crusher with an alcohol wipe and to let it dry in between use. Especially if you are using it to crush a different substance.
Testing Drugs
Now that your drugs are a fine powder, you can snort them. It is recommended to do any drug testing prior to snorting. Presses can often contain more substances than they are sold as. And the content of substances in your press can be lower or higher than what it's sold as.
Drug testing kits are available at:
qtests.org (dosage)
dancesafe.org (drug checking)
bunkpolice.com (drug checking + dosage)
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Snorting
After your drugs are finely crushed, measure out the amount of drugs you plan to snort. Know what constitutes a light, common, and heavy dose for the substance you are going to use.
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DO NOT EYEBALL. Eyeballing is not recommended as it is highly innacurate and unreliable. Eyeballing can put you at higher risk of overdose. Measure your drugs with a milligram scale.
When your drugs are measured, pour them onto a clean surface and use a piece of cardstock, hard plastic, or a clean razor to cut your drugs into lines. Don't use banknotes or keys for snorting. Use a plastic straw, paper straw, or a glass stem.
Exhale, put the straw or glass stem in your nose (make sure it goes in above your nose hairs), and then inhale the drugs through the straw. After all the drugs are snorted, exhale out the mouth, and then put a couple drops of sterile water up your nose.
To reduce risk or irritation, use a vitamin e oil or saline spray after snorting and switch between nostrils on a regular basis.
Naloxone
It is still possible to overdose while snorting. Because of this, it is very important to carry naloxone on you. Naloxone comes in both nasal spray and IM injections.
0.4mg/mL IM and 3mg or 4mg IN naloxone are the best doses. Higher doses such as 5mg IM or 8mg IN naloxone increases the risk of withdrawal symptoms and put the person in more harm.
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If you need to access naloxone but don't know where to go, I highly recommend Next Distro. I got IM naloxone from there for free and the people from there are wonderful.
For more resources on safe snorting and reponsible drug use:
youtube
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maaarine · 1 year
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The Cause of Depression Is Probably Not What You Think (Joanna Thompson, Quanta Magazine, Jan 26 2023)
"A literature review that appeared in Molecular Psychiatry in July was the latest and perhaps loudest death knell for the serotonin hypothesis, at least in its simplest form.
An international team of scientists led by Joanna Moncrieff of University College London screened 361 papers from six areas of research and carefully evaluated 17 of them.
They found no convincing evidence that lower levels of serotonin caused or were even associated with depression.
People with depression didn’t reliably seem to have less serotonin activity than people without the disorder.
Experiments in which researchers artificially lowered the serotonin levels of volunteers didn’t consistently cause depression. (…)
Although serotonin levels don’t seem to be the primary driver of depression, SSRIs show a modest improvement over placebos in clinical trials.
But the mechanism behind that improvement remains elusive.
“Just because aspirin relieves a headache, [it] doesn’t mean that aspirin deficits in the body are causing headaches,” said John Krystal, a neuropharmacologist and chair of the psychiatry department at Yale University.
“Fully understanding how SSRIs produce clinical change is still a work in progress.”
Speculation about the source of that benefit has spawned alternative theories about the origins of depression. (…)
Repple warns, however, that another explanation for the effects his team observed is also possible: Perhaps the depressed patients’ brain connections were impaired by inflammation.
Chronic inflammation impedes the body’s ability to heal, and in neural tissue it can gradually degrade synaptic connections.
The loss of such connections is thought to contribute to mood disorders.
Good evidence supports this theory.
When psychiatrists have evaluated populations of patients who have chronic inflammatory diseases like lupus and rheumatoid arthritis, they’ve found that “all of them have higher-than-average rates of depression,” said Charles Nemeroff, a neuropsychiatrist at the University of Texas, Austin.
Of course, knowing that they have an incurable, degenerative condition may contribute to a patient’s depressed feelings, but the researchers suspect that the inflammation itself is also a factor.
Medical researchers have found that inducing inflammation in certain patients can trigger depression.
Interferon alpha, which is sometimes used to treat chronic hepatitis C and other conditions, causes a major inflammatory response throughout the body by flooding the immune system with proteins known as cytokines — molecules that facilitate reactions ranging from mild swelling to septic shock.
The sudden influx of inflammatory cytokines leads to appetite loss, fatigue and a slowdown in mental and physical activity — all symptoms of major depression.
Patients taking interferon often report feeling suddenly, sometimes severely, depressed.
If overlooked chronic inflammation is causing many people’s depression, researchers still need to determine the source of that inflammation.
Autoimmune disorders, bacterial infections, high stress and certain viruses, including the virus that causes Covid-19, can all induce persistent inflammatory responses.
Viral inflammation can extend directly to tissues in the brain. Devising an effective anti-inflammatory treatment for depression may depend on knowing which of these causes is at work.
It’s also unclear whether simply treating inflammation could be enough to alleviate depression.
Clinicians are still trying to parse whether depression causes inflammation or inflammation leads to depression. “It’s a sort of chicken-and-egg phenomenon,” Nemeroff said.
Increasingly, some scientists are pushing to reframe “depression” as an umbrella term for a suite of related conditions, much as oncologists now think of “cancer” as referring to a legion of distinct but similar malignancies.
"And just as each cancer needs to be prevented or treated in ways relevant to its origin, treatments for depression may need to be tailored to the individual."
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devotioncrater · 1 year
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house m.d. truly gives one of thee biggest representation whiplashes in tv history because like:
- there is an asian lesbian couple having a baby boy. they serve as a foil for a white hetero couple having a baby girl. both newborns get sick. one baby is given the correct antidote while the other isn't because the team don't know what is causing the illnesses in the NICU. the white lady tells chase or cameron that she fears her relationship isn't going to survive the loss of the baby because that's what statistically happens. she doesn't have to worry tho because it's the lesbian couple's baby boy who dies, with the foiled implication their relationship won't survive
- a high-ranking mafia man who's been to prison comes in for treatment. his brother is his lawyer. there's a witness protection deal at stake here that the brother doesn't want him to go into. turns out the mafia man has hepatitis c. his brother vehemently denies his brother is gay and calls him a fag. turns out the mafia man has a case of homosexuality. the only way he can live his life authentically is if he goes into witness protection. the brother comes around and says he loves him and will support him in that. they can never see each other again.
- the first latino representation in the show is cuddy's handyman. he stereotypically works twenty different jobs to provide for his mom and his younger brother. he and his mom can't speak english well but his younger brother is talented academically. his hand goes necrotic. the team break into both his home and cuddy's to investigate. he lives in a rundown apartment because his family and him are poor. they have to amputate his hand because the illness cuddy thought to treat him for made the necrosis worse. house overhears his younger brother is going to cover for him at a warehouse gig. cuddy and foreman follow and discover the actual illness came from an illegal underground cockfighting ring. in new jersey.
- a black father is super proud his son graduated princeton. they have a healthy supportive relationship with each other. the son suddenly gets ill with unexplained electric shocks as well as other symptoms. as the son's health deteriorates throughout the episode, it's discovered they've both been lying to one another about things such as spring break trips to jamaica, and how the mother died 15 years ago. house can't identify the son's health problem until the son's white princeton classmate (who he went to jamaica with) is triaged into the ER for vomiting blood and he mentions the dad owns a metal scrapyard. turns out it was radiation poisoning thanks to a freak radioactive metal piece from said scrapyard, which the son had on his backpack as a good luck charm. the dad and the white classmate get better. the black son who graduated princeton dies.
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misforgotten2 · 6 months
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Ain’t no pantry like a west coast pantry ‘Cause a west coast pantry don’t stock Heinz
(C•H•B not associated with Chronic Hepatitis B)
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mariacallous · 8 months
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The myth that there is a humane way to execute someone who wants to live is getting harder to maintain in Alabama.
In early 2018, the state tried to execute a terminally ill man, Doyle Lee Hamm, whose veins had deteriorated from drug use and treatment for cancer and hepatitis C. Executioners, whose identities are concealed but who typically do not have medical backgrounds, repeatedly jabbed him in the legs, ankles and groin as they tried to set the IV line. They stopped only when the death warrant was close to expiring and Hamm’s groin was covered in blood. 
A few weeks later, the state authorized a new execution method: death by nitrogen gas. At the time, it was purely hypothetical. Two other states allow it, but there had never been a known instance of a nitrogen execution. 
That changed on Thursday, when Alabama killed 58-year-old Kenneth Smith by affixing a mask over his face and forcing him to inhale only nitrogen. He “appeared to shake and writhe on the gurney, sometimes pulling on the restraints” for at least two minutes, followed by several minutes of heavy breathing, The Associated Press reported.  
“It was the most horrible thing I think I’ve ever seen,” said the Rev. Jeff Hood, Smith’s spiritual adviser, who has observed five executions in the past 13 months. 
This was Smith’s second time in an execution chamber. A little more than a year ago, he spent four hours strapped to a gurney, awaiting execution as his final appeals made their way through the court system. Executioners jabbed his hands, arms and collarbone before finally calling off his lethal injection. The botched execution left him severely traumatized. He experienced nightmares, hypervigilance, hyperarousal and dissociation up until his death. 
Smith’s 2022 experience was the third in a series of consecutive botched executions in Alabama. 
In the lead-up to Smith’s death, his lawyers urged the courts to block the nitrogen execution, warning that Smith risked facing a slow, painful death by asphyxiation — or even surviving but in a “persistent vegetative state.” 
The state attorney general’s office dismissed those concerns, claiming that nitrogen is “perhaps the most humane method of execution ever devised,” a baseless supposition undermined by the American Veterinary Medical Association’s recommendation that nitrogen not be used to euthanize most mammals. Rats who were exposed to nitrogen gas showed signs of “panic and distress” before they died, the group said.  
The U.S. Supreme Court allowed the execution to proceed, with the three liberal justices dissenting. 
“Twice now this Court has ignored Smith’s warning that Alabama will subject him to an unconstitutional risk of pain. The first time, Smith’s predictions came true,” Justice Sonia Sotomayor wrote in her dissent on Thursday, just before the execution. “This time, he predicts that Alabama’s protocol will cause him to suffocate and choke to death on his own vomit. I sincerely hope that he is not proven correct a second time.” 
“The world is watching,” Sotomayor wrote.  Other executing states are watching, too. As states struggle to carry out lethal injections in the face of litigation and opposition from drug companies, many are looking for new ways to kill — including firing squads and even cyanide gas, the preferred killing method of Nazi Germany. That the Supreme Court allowed Alabama to evade accountability over one secretive execution method by simply switching to another will not go unnoticed in other states.
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sapphic-sex-ed · 2 months
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my girlfriend and i want to get more intimate with each other but im concerned about possibly contracting an STD/STI. can we contract one of we’re both clean and use no dams? or is protection always the way to go?
STD/STI are acronyms for Sexually Transmitted Diseases/Sexually Transmitted Infections and as with any disease, if you are not exposed to the virus/bacteria that causes it, you cannot transmit it. If you have been tested and have the results come back negative, you do not have the disease and cannot transmit it*.
If you have not been tested but don't experience any symptoms (and has had previous sexual partners), you can still be infected and transfer the disease. It is believed that upwards of 80% of humans are infected with herpes (HSV1 or HSV2) but most don't show any symptoms, called being asymptomatic. Other STIs where it's common to be asymptomatic are chlamydia, HPV/genital warts (only some strains cause warts), and latent syphilis (although you would have noticed syphilis symptoms like rashes before the latent phase, which is a phase that sometimes occurs before the third/final stage of the disease).
If neither of you have had partners before**, or if you have been tested negative 3 months after your last sexual encounter, you don't have an STI.
Furthermore, hand and oral sex on vulvas are considered the safest ways to have sex when it comes to transmission of STIs. Now, I don't know you or your partner's genitals but I'm guessing based on the dental dam comment that it's likely that the sex you'll be having will mainly involve vulvas. While you absolutely can contract an STI in your throat, the amount of vaginal fluid you would have to guzzle to get enough pathogens down to your throat to cause infection is a lot. Semen is a lot more effective at transmitting diseases because, uh, its purpose is to get that shit (spermatozoa) in there, so to speak. It's not risk free, but nothing in life is. This is so low risk that the Swedish organization for sexual and reproductive rights and education (founded in the 30's, leading org for SRHR in the nation) which also produce and sell condoms, at home pregnancy and STI-tests, lube, etc, don't sell dental dams at all. That being said, dams can be fun to play with vis a vis sensation (taut dam vs relaxed dam, for example) and if you want to use one I would never dissuade you from it.
I do wanna bring attention to the usage of the word "clean" to denote that you aren't infected with an STI. It's a common way to phrase it, but it does stigmatize those who have been or are infected with an STI. To say that one is "clean" to mean "not infected" directly implies that to be infected is dirty or unclean, which it is not. This is part of the stigma of contracting and living with an STI, where a moral judgement is cast upon the person. As some STIs are life long, like HIV, herpes, and sometimes hepatitis, the stigma can also be life-long. In the future, I suggest using terms like "not infected" or "tested negative" to avoid this.
-mod liz
*because of incubation time, you have to wait up to three months for some STIs to show up on a test, so if you sleep with a new partner, getting tested the next week may not yield accurate results.
**some STIs are not exclusively sexually transmitted. You can for example contract HIV at birth if your parent was a carrier, hepatitis C can spread through blood, and herpes can infect both mouth and genitals and sharing a glass of water with somebody with oral herpes can transmit it. Unless there's any reason to suspect that you have contracted HIV or hepatitis from somewhere else (like a tattoo or injection needle, or if you mixed your blood with somebody somehow like in an accident) I wouldn't be too worried though.
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thoughtportal · 3 months
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What could be causing the rise?
Some scientists posit that the Covid virus itself could be contributing to the higher numbers of cancer diagnoses, especially for those who are suffering from long Covid. "The idea that some viruses can cause or accelerate cancer is hardly new," said the Post. "Scientists have recognized this possibility since the 1960s, and today, researchers estimate 15% to 20% of all cancers worldwide originate from infectious agents such as HPV, Epstein-Barr and hepatitis B." 
Because "infection with SARS-CoV-2 occurs in several organs either directly or indirectly, it is expected that cancer stem cells may develop in multiple organs," said a 2023 study published in the journal Biochimie. Lung, colorectal, pancreatic and oral cancer could particularly be exacerbated. 
While not officially confirmed, the virus is said to cause full-body inflammation. "Inflammation triggers many genetic changes in a genome that can create a propensity of developing cancer in certain individuals," Dr. Kashyap Patel, CEO of Carolina Blood and Cancer Care Associates, said to News Nation. "We are completely under-investigating this virus," Douglas C. Wallace, a geneticist and evolutionary biologist at the University of Pennsylvania, said to the Post. "The effects of repeatedly getting this throughout our lives is going to be much more significant than people are thinking."
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The Physiology Of The Liver
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The liver is a vital organ responsible for numerous functions including metabolism, immunity, digestion, detoxification, and vitamin storage. It weighs around 2% of an adult’s body weight and is unique due to its dual blood supply from the portal vein (75%) and the hepatic artery (25%).
Cellular Structure
The liver’s functional unit is the lobule, which is hexagonal in shape. Each corner of the hexagon has a portal triad consisting of the portal vein, hepatic artery, and bile duct. The lobule is composed mainly of hepatocytes, which have distinct apical and basolateral membranes. Hepatocytes are categorized into three zones based on their function and blood supply:
Zone I (periportal region): Closest to the blood supply, involved in oxidative metabolism (e.g., gluconeogenesis, bile formation).
Zone II (pericentral region): Sits between Zones I and III.
Zone III: Farthest from the blood supply, primarily involved in detoxification and biotransformation.
Blood and bile flow in opposite directions within the liver. The space of Disse, between the hepatocytes and the sinusoidal lumen, contains Kupffer cells (macrophages) and Ito cells (fat-storing stellate cells).
Development
The liver develops from endodermal cells of the foregut as the hepatic diverticulum around the fourth week of embryonic development. It undergoes complex differentiation influenced by various pathways (e.g., Wnt/β-catenin, FGF). By the sixth week, the liver participates in hematopoiesis, and hepatocytes begin bile production by the 12th week.
Organ Systems and Functions
The liver interacts with multiple body systems:
Digestive and Metabolic Roles: Aids in digestion, stores fat-soluble vitamins, and handles cholesterol.
Hematological Functions: Produces clotting factors and proteins.
Detoxification: Metabolizes drugs and other xenobiotics through phase I (oxidation, reduction, hydrolysis) and phase II (conjugation) reactions.
Bilirubin Metabolism: Converts heme to unconjugated bilirubin, then conjugates it for excretion.
Hormonal and Protein Synthesis: Involved in thyroid hormone activation and synthesis of nearly all plasma proteins.
Related Testing
Liver function tests (LFTs), including ALT, AST, bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase (GGT), help assess liver health. Imaging techniques like ultrasound, CT, and MRI are also employed to identify liver abnormalities.
Pathophysiology
Cirrhosis results from chronic liver injury (e.g., due to alcoholism, hepatitis B and C), leading to fibrosis and necrosis. It causes symptoms like portal hypertension, coagulopathy, and jaundice. Hepatitis viruses (A, B, C, D, E), autoimmune diseases (e.g., primary biliary cholangitis), and metabolic conditions (e.g., non-alcoholic fatty liver disease) also contribute to liver pathology.
Clinical Significance
Understanding liver physiology helps manage conditions like viral hepatitis, alcoholic liver disease, benign liver lesions, and liver cancers. Early detection through appropriate testing and management strategies is essential for preventing end-stage liver disease and improving patient outcomes
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dollsandmasks · 2 months
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If you, just like me, grew up labelled as a "good kid", it can be hard to finally go against what is forced upon you by someone's authority.
Especially when it comes to doctors and medication.
I've always been a good kid. I did everything doctors told me. I dieted, I kept taking more and more medication, I never spoke over them or against them, because they know best. Doctors are respectable, they are trying to help. My mom is a doctor. I got back some very shady-looking bloodwork as an adult and never questioned it, just assuming that I had somehow missed having been sick with hepatitis C at some point. The bloodwork turned out to be botched, and I had to go to another town to get it re-taken, showing that I have never, in fact, had hepatitis C. It is likely still a part of my medical records somewhere, though.
I am currently seeing a lot of doctors, as I finally have insurance and can get help for the smaller issues I've been having throughout the years. And yeah, it's kind of a mess. I keep being sent to different doctors from the same field, and they don't communicate with each other. They misread my papers, have trouble accessing my test results and scheduling follow-up sessions, they can be rude and dismissive sometimes, but overall, I'm doing fine, and I'm following their recommendations to a T. And they help, even if actually being listened to might have helped a bit more.
But sometimes, they'll send you to a psychiatrist to rule out some of your symptoms maybe being psychosomatic (because, you see, the only results of yours they could access were your most recent, good results, not the abysmally bad results you had at the beginning of the month, so now your abysmally bad results didn't sound real enough to them to still be causing any lasting issues), and the psychiatrist will be one of those types. The "autism is a terrible disease, but you can be cured!" type. The "you are sick in the head and must be immediately hospitalized, even though mental institution patients in Russia permanently lose some of their human rights" type, the "going into remission for your autism can cure everything, including your actual infections, and don't you dare not want to get rid of your terrible mental disease!" type. And, after pushing you, intimidating you, constantly switching the narrative and lying about what type of medication you are being prescribed, after refusing to elaborate about the side effects and essentially shooing you out while insisting you come back next time fully medicated (despite the next time not being covered by the insurance, and even the first time getting the psychiatrist up in arms about whether or not your insurance really covers it), the psychiatrist leaves you with a list of medications, after you have already extensively told them all about the horrible, life-threatening side effects you've had with similar types of medications before. You look these up online, and the side effects sounds like exactly the type of thing you want to avoid. Your mental health is not as bad right now as it used to be, your main problems are physiological, and it's not the right time to go and risk experiencing such a vast array of side effects that you were never able to escape with these types of meds.
But you want to be a good kid. A medical professional prescribed you medication and insisted that you take them. They also insisted on you coming back and checking in with them, about raising the "baby dosages" that had been prescribed. You are a good kid, good kids do what authorities tell them to! They take the medication and suffer the consequences, because the doctor knows best.
This is where you stop being a good kid and become a reasonable adult who doesn't want to risk fucking dying because they are dealing with some of the most incompetent medical professionals known to man.
I am still as pro-therapy and pro-medication as I was before, but I will keep on looking for a professional who doesn't make me want to write an official complaint about them three minutes in. They must truly believe that mentally ill and developmentally disabled people are incapable of defending themselves and exercising their rights.
Welp, gotta prove them wrong.
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Atea finally gives up COVID ambitions after antiviral fails to reduce hospitalizations, deaths in phase 3 - Published Sept 13, 2024
By James Waldron
Atea Pharmaceuticals’ antiviral has failed another COVID-19 trial, but the biotech still holds out hope the candidate has a future in hepatitis C.
The oral nucleotide polymerase inhibitor bemnifosbuvir failed to show a significant reduction in all-cause hospitalization or death by Day 29 in a phase 3 trial of 2,221 high-risk patients with mild to moderate COVID-19, missing the study’s primary endpoint. The trial tested Atea's drug against placebo.
Atea’s CEO Jean-Pierre Sommadossi, Ph.D., said the biotech was “disappointed” by the results of the SUNRISE-3 trial, which he attributed to the ever-changing nature of the virus.
“Variants of COVID-19 are constantly evolving and the natural history of the disease trended toward milder disease, which has resulted in fewer hospitalizations and deaths,” Sommadossi said in the Sept. 13 release.
“In particular, hospitalization due to severe respiratory disease caused by COVID was not observed in SUNRISE-3, in contrast to our prior study,” he added. “In an environment where there is much less COVID-19 pneumonia, it becomes more difficult for a direct-acting antiviral to demonstrate impact on the course of the disease.”
Atea has struggled to demonstrate bemnifosbuvir’s COVID potential in the past, including in a phase 2 trial back in the midst of the pandemic. In that study, the antiviral failed to beat placebo at reducing viral load when tested in patients with mild to moderate COVID-19.
While the study did see a slight reduction in higher-risk patients, that was not enough for Atea’s partner Roche, which cut its ties with the program.
Atea said today that it remains focused on exploring bemnifosbuvir in combination with ruzasvir—a NS5B polymerase inhibitor licensed from Merck—for the treatment of hepatitis C. Initial results from a phase 2 study in June showed a 97% sustained virologic response rate at 12 weeks, and further top-line results are due in the fourth quarter.
Last year saw the biotech turn down an acquisition offer from Concentra Biosciences just months after Atea sidelined its dengue fever drug after deciding the phase 2 costs wouldn’t be worth it.
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viezec · 4 months
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What You Need To Know About Causes Of Liver Disease?
Liver disease | Hepatitis | Cirrhosis | Fatty liver disease | Liver failure | Liver fibrosis | Alcoholic liver disease | Liver regeneration | Liver stem cells | Best Treatment For Liver Disease | Stem Cell Treatment For Liver Disease | Exosome Therapy | Regenerative Medicine | Stem Cell Therapy Center For Liver | Organ Disease |
There are many different types of liver disease, each with their own unique set of causes. However, there are some commonalities among the various types of liver disease that are worth noting. Firstly, liver disease is often caused by excessive alcohol consumption. This can damage the liver cells and lead to scarring of the organ, known as cirrhosis. Obesity is another major risk factor for developing liver disease, as it can lead to fatty deposits building up in the liver and eventually causing inflammation. Viral infections such as hepatitis C are also a common cause of liver disease and can result in chronic inflammation of the organ.
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beardedmrbean · 4 months
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Infected blood victims could each receive payments of more than £2 million under a compensation scheme announced by the government.
Ministers set out the figures as they unveiled the proposed scheme following publication of the public inquiry's report into the scandal on Monday.
That said authorities covered up the scandal and exposed victims to unacceptable risks.
The government said the first payments will be made by the end of the year.
In the meantime, it said it would make extra interim payments of £210,000 over the summer.
Those will be to 4,000 victims who have already received payments of £100,000.
But the government said compensation would eventually be made available to a much wider group of people, including to the family and loved-ones of those who have been infected. This could include the children or parents - the first time they will have received any financial payment.
The total cost could eventually be in the region of £10 billion.
The infected blood inquiry has been called the worst treatment disaster in the history of the NHS.
More than 30,000 people were infected with HIV and hepatitis C from 1970 to 1991 by contaminated blood products and transfusions.
About 3,000 of them have since died - many haemophiliacs given infected blood products as part of their treatment.
'Five criteria'
The compensation due will be judged under five criteria:
injury and harm caused
social impact from stigma and isolation
impact on autonomy and private life, such as not being able to have children
care costs
financial loss
The government said payments would depend on individual circumstances, but typical payouts for those infected with HIV, or for HIV plus hepatitis, would be in excess of £2 million.
Those with a hepatitis infection causing liver damage would get around £1 million.
Those who face extreme care costs or who were very high earners before infection could get even more.
The figures released also give examples of compensation awards for the family members of those infected.
The partner of someone infected with HIV who is still alive today, for example, should expect to receive around £110,000, while a child could get £55,000.
If their loved-one has died and they were financially dependent on them, annual payments are available.
The scheme will be administered by a new body called the Infected Blood Compensation Authority, which will be led initially by Sir Robert Francis, who chaired the inquiry into the Stafford Hospital scandal.
It is proposed that the compensation will be taken as a lump sum or series of payments. The plans will be consulted on over the coming weeks.
From next April, the compensation scheme will effectively replace the existing financial support scheme - versions of which have been in place since 1989. In recent years they have been worth more than £40,000 a year to some, such as those who have been infected or, if they have died while benefitting, their partners.
Announcing the details in the House of Commons, paymaster general John Glen repeated the apology made by Prime Minister Rishi Sunak on Monday, saying the victims had suffered "unimaginable pain".
He said the publication of the public inquiry's report was a "day of great humility for everyone".
He hopes the compensation package will be welcomed: "The infected blood community know their cries for justice have been heard."
Des Collins, of Collins Solicitors, which is representing over 500 families, said the news was a "positive step and broadly encouraging".
But he criticised the government for not acting earlier, pointing out they were told to act on compensation by the public inquiry two years ago.
"The government has wasted valuable time. Why the promised further consultation has not happened sooner is also bewildering, but better late than never."
Jason Evans, of the campaign group Factor 8, said he would need to carefully consider the compensation sums before commenting.
But he said he was concerned about the wait some face given the interim payments are only available to certain individuals.
"Today's announcement will be a gut-punch to most bereaved families, who have still received no compensation at all."
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*DR. SMITA GOEL HOMEOPATHY CLINIC*
www.thehomeopathyclinic.co.in
The liver is a largest, meaty organ. It has weight about 3 pounds, the liver is reddish-brown in colour and feels rubbery to the touch. Normally you can't feel the liver, because it's protected by the rib cage.
The liver has two large sections, called the right and the left lobes. The gallbladder sits under the liver, along with parts of the pancreas and intestines. The liver and these organs work together to digest, absorb, and process food.
The liver's main job is to filter the blood coming from the digestive tract, before passing it to the rest of the body. The liver also detoxifies chemicals and metabolizes drugs. As it does so, the liver secretes bile that ends up back in the intestines. The liver also makes proteins important for blood clotting and other functions.
There are following types of liver disease:
• Hepatitis: Inflammation of the liver, usually caused by viruses like hepatitis A, B, and C. Hepatitis can have non-infectious causes too, including heavy drinking, drugs, allergic reactions, or obesity.
• Cirrhosis: Long-term damage to the liver from any cause can lead to permanent scarring, called cirrhosis. The liver then becomes unable to function well.
• Liver cancer: The most common type of liver cancer, hepatocellular carcinoma, almost always occurs after cirrhosis is present.
• Liver failure: Liver failure has many causes including infection, genetic diseases, and excessive alcohol.
• Ascites: As cirrhosis results, the liver leaks fluid (ascites) into the belly, which becomes distended and heavy.
• Gallstones: If a gallstone becomes stuck in the bile duct draining the liver, hepatitis and bile duct infection (cholangitis) can result.
• Hemochromatosis: Hemochromatosis allows iron to deposit in the liver, damaging it. The iron also deposits throughout the body, causing multiple other health problems.
• Primary sclerosing cholangitis: A rare disease with unknown causes, primary sclerosing cholangitis causes inflammation and scarring in the bile ducts in the liver.
• Primary biliary cirrhosis: In this rare disorder, an unclear process slowly destroys the bile ducts in the liver. Permanent liver scarring (cirrhosis) eventually develops.
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lorddarkkitty · 5 months
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Leaving off from volume 2 the girls are at the top of the river after saving someone and these knights come and apprehends them. Saying that one of them for formed very dangerous magic that change the landscape. And about to erase their memory.
So Richeh flys into this knights arm and Tetia destroys the thing that keeping Agott and Coco tied up.
Tetia express that it isn’t right for them to not listen to what Coco and Agott have to say and Richeh express she hates adults that treat children like things instead of humans. And I’m absolutely living for it cause she is so right. They are human and should be treated as such. Quifrey also shows up behind the knight who name is Easthies and I hate him. Cause he comes off, how do I say super strict? but that doesn’t fit. But he was gonna act first ask questions later type. Like he talks about justice but was about to erase the mind of two INNOCENT GIRLS. And he insults master Quifrey. Any way the other adult that was with Quifrey (I might have to make a list of their names for reference cause I can’t remember atm lol) so the other dude like “uhh hey are y’all gonna stand around and argue or are y’all gonna help cause that’s the whole point of being a witch is to bring blessings to ppl without magic” basically that’s not a quote of what he actually said. So after the ppl been tended to Easthies questions Coco. Using ink and draws the sigil she used to turn the stone to sand. Basic. So Easthies examines Coco’s hands cause the “brimmed caps” would put sigil on their bodies for power ups. WHY WOULD COCO DO THIS IDK. I doubt she even knew you could put sigils on the body. But he finds nothing but an apprentice learning how to draw spells. And they leave. Good get gone Easthies you asshat of a witch. I don’t like him.
After that Quifrey tells the girls that they shouldn’t have used magic so dangerously close to non witches cause it could expose them and then they would have to erase peoples mind which is very delicate so they don’t want to do that. But also expressed that Agott should take the second test. He a good teacher … still have my suspicions tho lol.
It changed to Easthies and the knights flying through the air showing the destruction Coco spell has done and expressing that there will be a proper investigation cause he doesn’t trust that Coco didn’t do it even tho she 10 and just learning and that her spell shouldn’t be that strong. So some confusion there lol.
Then it goes back to Quifrey and the apprentices along with the other dude I don’t know his name, Oleruggio is it lol. They make a brigade of sand but before they leave Quifrey picks up Cocos hat and her ink bottle falls out. So he giving her a light scolding cause non witches can’t see that. And Coco expresses that she been using it but it still has fall as ever and Quifrey seems to figure out why Coco spell was so strong. We find out that t that the brimmed cap that gave coco the spell book, switched out her ink with blood. Which is gross and unsanitary and that’s how you get hepatitis C. I really want to know their plans for Coco cause what are u up to???
Anyway Qifrey has to take Coco back to Kalhn "b/c he forgot to buy cod a wand" when really he going to talk to nolnoa about the ink. Tartah brings Coco to this room filled with different powders all in a specific order (Cause we learn he has something called Silverfish Syndrome) Coco was getting excited about everything but then a big flash of light happens and lots of the shelves and jars get knocked down and over. the labels fell off so his grandfather is going to have to fix it. Sucks that this isn't a way to help ppl with this type of color blind condition. Qifrey also did something that he even says it shouldn't be done but erasing someone's mind. shame! shame! He looking for something idk what his goals are but that one eye hat witch find out and kinda takes back the ink.
Gonna fast-forward cause they learning and stuff at some point Coco gets a fever and collapses and needed to head to the hospital where Tartah happened to run into them. he had to return there cause he forgot his hat so he couldn't get on a boat to get home. a fire broke out somewhere and of course Qifrey and others witches help out. Tartah hat was in the room Coco's in. He tried finding someone to help but couldn't find anyone and he wants to help coco but there aren't any labels cause he knows what he can give her. as he goes to give her water he gets a jimmy neutron brain blast with the water holder? thingy?. he separates solids and liquids and is looking for the one the turns into a powder and he got down to three. and he starts to get upset and about to give up. My favorite part is that Coco tells him that That is what magic is for. "To turns things you can't do into things you can do!" Coco tries to draw a spell to help him but she obviously sick and gets embarrassed. However, the spell is good just needs some fine tuning basically. which Tartah suggests putting some symbols in certain places and he draw the sigil allowing him to see the original form of the powders helping him identify the herb he needed. only for a nurse to come see what he was doing in the room filled with medicines wondering why he was there. but that tranquileaf I think it was called was correct. I loved that Coco did her sickly best to help Tartah. Cause really what's the point if you can't make someone's life easy.
Also we see another character be introduced that is an embodiment of forbidden magic ....and it cause a cap and a hat ...with not visible person there..A GHOST LOL
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