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Engineers develop a vibrating, ingestible capsule that might help treat obesity
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Engineers develop a vibrating, ingestible capsule that might help treat obesity
When you eat a large meal, your stomach sends signals to your brain that create a feeling of fullness, which helps you realize it’s time to stop eating. A stomach full of liquid can also send these messages, which is why dieters are often advised to drink a glass of water before eating.
MIT engineers have now come up with a new way to take advantage of that phenomenon, using an ingestible capsule that vibrates within the stomach. These vibrations activate the same stretch receptors that sense when the stomach is distended, creating an illusory sense of fullness.
In animals who were given this pill 20 minutes before eating, the researchers found that this treatment not only stimulated the release of hormones that signal satiety, but also reduced the animals’ food intake by about 40 percent. Scientists have much more to learn about the mechanisms that influence human body weight, but if further research suggests this technology could be safely used in humans, such a pill might offer a minimally invasive way to treat obesity, the researchers say.
“For somebody who wants to lose weight or control their appetite, it could be taken before each meal,” says Shriya Srinivasan PhD ’20, a former MIT graduate student and postdoc who is now an assistant professor of bioengineering at Harvard University. “This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there.”
Srinivasan is the lead author of the new study, which appears today in Science Advances. Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital, is the senior author of the paper.
A sense of fullness
When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates production of insulin, as well as hormones such as C-peptide, Pyy, and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down.
While a graduate student at MIT, Srinivasan became interested in the idea of controlling this process by artificially stretching the mechanoreceptors that line the stomach, through vibration. Previous research had shown that vibration applied to a muscle can induce a sense that the muscle has stretched farther than it actually has.
“I wondered if we could activate stretch receptors in the stomach by vibrating them and having them perceive that the entire stomach has been expanded, to create an illusory sense of distension that could modulate hormones and eating patterns,” Srinivasan says.
As a postdoc in MIT’s Koch Institute for Integrative Cancer Research, Srinivasan worked closely with Traverso’s lab, which has developed many novel approaches to oral delivery of drugs and electronic devices. For this study, Srinivasan, Traverso, and a team of researchers designed a capsule about the size of a multivitamin, that includes a vibrating element. When the pill, which is powered by a small silver oxide battery, reaches the stomach, acidic gastric fluids dissolve a gelatinous membrane that covers the capsule, completing the electronic circuit that activates the vibrating motor.
In a study in animals, the researchers showed that once the pill begins vibrating, it activates mechanoreceptors, which send signals to the brain through stimulation of the vagus nerve. The researchers tracked hormone levels during the periods when the device was vibrating and found that they mirrored the hormone release patterns seen following a meal, even when the animals had fasted.
The researchers then tested the effects of this stimulation on the animals’ appetite. They found that when the pill was activated for about 20 minutes, before the animals were offered food, they consumed 40 percent less, on average, than they did when the pill was not activated. The animals also gained weight more slowly during periods when they were treated with the vibrating pill.
“The behavioral change is profound, and that’s using the endogenous system rather than any exogenous therapeutic. We have the potential to overcome some of the challenges and costs associated with delivery of biologic drugs by modulating the enteric nervous system,” Traverso says.
The current version of the pill is designed to vibrate for about 30 minutes after arriving in the stomach, but the researchers plan to explore the possibility of adapting it to remain in the stomach for longer periods of time, where it could be turned on and off wirelessly as needed. In the animal studies, the pills passed through the digestive tract within four or five days.
The study also found that the animals did not show any signs of obstruction, perforation, or other negative impacts while the pill was in their digestive tract.
An alternative approach
This type of pill could offer an alternative to the current approaches to treating obesity, the researchers say. Nonmedical interventions such as diet exercise don’t always work, and many of the existing medical interventions are fairly invasive. These include gastric bypass surgery, as well as gastric balloons, which are no longer used widely in the United States due to safety concerns.
Drugs such as GLP-1 agonists can also aid weight loss, but most of them have to be injected, and they are unaffordable for many people. According to Srinivasan, the MIT capsules could be manufactured at a cost that would make them available to people who don’t have access to more expensive treatment options.
“For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point,” she says. “I’d love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today.”
The researchers now plan to explore ways to scale up the manufacturing of the capsules, which could enable clinical trials in humans. Such studies would be important to learn more about the devices’ safety, as well as determine the best time to swallow the capsule before to a meal and how often it would need to be administered.
Other authors of the paper include Amro Alshareef, Alexandria Hwang, Ceara Byrne, Johannes Kuosmann, Keiko Ishida, Joshua Jenkins, Sabrina Liu, Wiam Abdalla Mohammed Madani, Alison Hayward, and Niora Fabian.
The research was funded by the National Institutes of Health, Novo Nordisk, the Department of Mechanical Engineering at MIT, a Schmidt Science Fellowship, and the National Science Foundation.
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Keto Care Reviews high light CBD Gummies Offer
Keto Care Reviews Scam and Legit How Does It Work Keto Care?
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Unlock Your Fitness Goals: Exploring the Power of Slimming Capsules for Women
In today's fast-paced world, maintaining a healthy lifestyle can be challenging, especially for women juggling multiple responsibilities. The desire to achieve and maintain a fit and toned physique is a common goal for many women. While regular exercise and a balanced diet are essential, there are additional tools available to support women in their fitness journeys. Fitness slimming capsules for women have gained popularity as a potential aid in weight management and achieving fitness goals. In this article, we will delve into the power of slimming capsules for women and explore their benefits and considerations.
At Couplehealthcare, we understand the importance of women's health and well-being, offering a range of slimming capsules designed specifically to assist women in their pursuit of a healthier lifestyle.
Understanding Slimming Capsules
1.1 What are Slimming Capsules?
Slimming capsules, also known as weight loss supplements, are dietary supplements formulated to assist in weight management and promote fat loss. These capsules typically contain a combination of natural ingredients that work synergistically to support various aspects of weight management.
1.2 How Do Slimming Capsules Work?
Slimming capsules work through different mechanisms. Some capsules help boost metabolism, allowing the body to burn more calories efficiently. Others may suppress appetite, reducing cravings and overeating. Some slimming capsules may also inhibit the absorption of dietary fats, thereby reducing calorie intake.
1.3 Ingredients in Slimming Capsules
The ingredients in slimming capsules can vary depending on the product. Common ingredients include green tea extract, caffeine, garcinia cambogia, forskolin, and various vitamins and minerals. These ingredients are carefully selected for their potential benefits in weight management.
1.4 Safety and Regulations
It's essential to choose slimming capsules from reputable manufacturers who adhere to strict quality and safety standards. Look for products that have been tested and approved by regulatory authorities. It's also crucial to follow the recommended dosage and consult with a healthcare professional before starting any new dietary supplement.
The Benefits of Slimming Capsules for Women
2.1 Weight Management and Fat Loss
Slimming capsules can support weight management efforts by boosting metabolism and promoting fat burning. When combined with exercise and a balanced diet, these capsules can help women achieve their weight loss goals more effectively. You can buy slimming capsules from the Couplehealthcare website.
2.2 Increased Energy and Metabolism
Many slimming capsules contain ingredients like caffeine and green tea extract, which can increase energy levels and enhance metabolism. This can provide women with the energy they need to stay active and engage in regular exercise routines.
2.3 Appetite Suppression
One of the challenges in weight management is controlling appetite and cravings. Slimming capsules often include appetite-suppressing ingredients that can help reduce the desire to overeat, making it easier to stick to a calorie-controlled diet.
2.4 Mood and Mental Well-being
Weight loss journeys can be emotionally challenging. Some slimming capsules contain ingredients that support mood and mental well-being, helping women stay motivated and focused on their goals.
2.5 Hormonal Balance
Hormonal imbalances can affect weight management in women. Certain slimming capsules are formulated to help regulate hormones, such as cortisol and insulin, which can influence fat storage and metabolism.
Choosing the Right Slimming Capsules
3.1 Assessing Individual Needs and Goals
Before selecting a slimming capsule, it's crucial to assess individual needs and weight loss goals. Consider factors such as current weight, body composition, overall health, and any pre-existing conditions.
3.2 Reading Labels and Understanding Product Claims
Carefully read the labels of slimming capsules and understand the product claims. Look for scientific evidence or clinical studies supporting the effectiveness of the ingredients. Avoid products that make exaggerated claims without substantial evidence.
3.3 Researching Product Reputation and Customer Reviews
Do thorough research on the reputation of the brand and the specific slimming capsule you're considering. Read customer reviews and testimonials to get insights into other users' experiences with the product.
3.4 Consulting with Healthcare Professionals
Consult with a healthcare professional, such as a registered dietitian or a physician, before incorporating slimming capsules into your routine. They can provide personalized advice and ensure the product is safe and suitable for you.
Incorporating Slimming Capsules into Your Fitness Routine
4.1 Pairing Slimming Capsules with Exercise
Slimming capsules can complement an exercise routine by providing energy and enhancing fat burning. Combine the capsules with a well-rounded exercise program that includes cardiovascular exercises and strength training for optimal results.
4.2 Combining Slimming Capsules with a Balanced Diet
Remember that slimming capsules are not a substitute for a healthy diet. Pair the capsules with a balanced, nutrient-dense eating plan that includes plenty of fruits, vegetables, lean proteins, whole grains, and healthy fats.
4.3 Establishing Realistic Expectations
While slimming capsules can support weight loss efforts, it's important to set realistic expectations. Healthy and sustainable weight loss is typically around 1-2 pounds per week. Avoid falling into the trap of quick-fix solutions or unrealistic promises.
4.4 Monitoring Progress and Adjusting Dosage
Regularly monitor your progress and adjust the dosage of slimming capsules as necessary. Pay attention to any changes in weight, body measurements, energy levels, and overall well-being. If needed, consult with a healthcare professional for guidance.
Precautions and Considerations
5.1 Potential Side Effects
Although slimming capsules are generally safe, some individuals may experience side effects. These can include gastrointestinal discomfort, increased heart rate, jitteriness, or allergic reactions. If any adverse effects occur, discontinue use and consult a healthcare professional.
5.2 Allergies and Sensitivities
Check the ingredient list of slimming capsules for any known allergies or sensitivities. If you have a history of allergies, carefully review the composition to ensure there are no potential triggers.
5.3 Pregnancy and Breastfeeding
Pregnant or breastfeeding women should avoid slimming capsules, as their safety during these periods is not well-established. Focus on maintaining a healthy diet and engaging in appropriate exercises under the guidance of a healthcare professional.
5.4 Interactions with Medications
If you are taking any medications, including prescription drugs or over-the-counter supplements, consult with a healthcare professional before starting slimming capsules. Some ingredients may interact with certain medications, affecting their efficacy or causing adverse effects.
5.5 Maintaining a Healthy Lifestyle
Remember that slimming capsules are just one part of a comprehensive approach to weight management. It's important to adopt and maintain a healthy lifestyle that includes regular physical activity, a balanced diet, adequate sleep, and stress management.
Conclusion
In conclusion, fitness slimming capsules for women can be a valuable tool for looking to unlock their goals and achieve a healthier lifestyle. When used in conjunction with regular exercise and a balanced diet, these capsules can enhance weight management efforts, boost energy levels, suppress appetite, improve mood, and support hormonal balance. However, it is crucial to choose high-quality products, conduct thorough research, and consult with healthcare professionals before incorporating slimming capsules into your fitness routine. At Couplehealthcare, we are committed to providing safe and effective slimming capsules tailored to women's specific needs. Remember, achieving your fitness goals is a journey, and taking small, sustainable steps is key to long-term success.
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Vitamin E: Symptoms of Deficiency
Vitamin E deficiency is relatively rare but can occur in certain situations, particularly when fat absorption is impaired or in individuals with specific genetic conditions. Here are some common symptoms and signs of E vitamin deficiency: Vitamin E: Neurological Problems Peripheral Neuropathy: Damage to the peripheral nerves causing numbness, tingling, and weakness, particularly in the hands…
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Indulge the Use of Ayurvedic Weight Loss Capsules in Delhi
Ayurvedic weight loss capsules in Delhi are the basic supplements that are used to reduce extra fat and metabolism from the human body. The main function of Ayurvedic weight loss capsules boosting metabolism, aiding digestion, and helping the body fat burn more effectively. These Ayurvedic Weight Loss Capsules in Delhi are available in the local market and also available online as well. They are very gentle and follow the traditional way of Ayurvedic Medication that cuts down heavy pounds while taking care of your complete health.
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NightDry Supplements - Health
NightDry Supplements: A Rescuer for Restless Nights!
For years, I was plagued by nightly visits to the loo. Disrupted sleep, a grumpy disposition by morning, and the constant worry of leaks – it was a right nightmare! I tried various things – cutting out fluids before bed, bladder exercises, even a particularly fetching adult nappy (not recommended!). Nothing seemed to work. Then, a friend recommended NightDry, and let me tell you, it's been a game-changer!
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Since taking NightDry, those nightly treks to the bathroom are a thing of the past. I can finally sleep through the night without interruption. This has made a world of difference to my energy levels. No more dragging myself out of bed feeling like a deflated balloon! I wake up feeling refreshed and ready to tackle the day.
Confidence Boost and Social Fun Restored
The constant worry about leaks had me avoiding social gatherings and outings. I wouldn't dare go for a long walk or even a trip to the cinema for fear of an embarrassing accident. NightDry has given me back my confidence. Now, I can enjoy evenings out with friends and family without a care in the world.
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A Brighter Outlook
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Find restful sleep and claim your mind with TRELEST- your natural solution for stress and insomnial
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Sea Moss Capsules - Vital Nutrients | GFGV
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Me-Shield Immunity Booster Syrup and Capsule
Boost Immune System Helps to Rejuvenate Mind and Body Fights Against Respiratory Complaints Holds Liver Detoxification Properties
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Engineers develop a vibrating, ingestible capsule that might help treat obesity - Technology Org
New Post has been published on https://thedigitalinsider.com/engineers-develop-a-vibrating-ingestible-capsule-that-might-help-treat-obesity-technology-org/
Engineers develop a vibrating, ingestible capsule that might help treat obesity - Technology Org
When you eat a large meal, your stomach sends signals to your brain that create a feeling of fullness, which helps you realize it’s time to stop eating. A stomach full of liquid can also send these messages, which is why dieters are often advised to drink a glass of water before eating.
MIT engineers designed an ingestible capsule that vibrates within the stomach, creating an illusory sense of fullness and reducing appetite. The pill could offer a minimally invasive, cost-effective way to treat obesity. Illustration by the researchers, MIT News
MIT engineers have now come up with a new way to take advantage of that phenomenon, using an ingestible capsule that vibrates within the stomach. These vibrations activate the same stretch receptors that sense when the stomach is distended, creating an illusory sense of fullness.
In animals who were given this pill 20 minutes before eating, the researchers found that this treatment not only stimulated the release of hormones that signal satiety, but also reduced the animals’ food intake by about 40 percent. Scientists have much more to learn about the mechanisms that influence human body weight, but if further research suggests this technology could be safely used in humans, such a pill might offer a minimally invasive way to treat obesity, the researchers say.
“For somebody who wants to lose weight or control their appetite, it could be taken before each meal,” says Shriya Srinivasan PhD ’20, a former MIT graduate student and postdoc now an assistant bioengineering professor at Harvard University. “This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there.”
Srinivasan is the new study’s lead author, which appears in Science Advances. Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital, is the paper’s senior author.
A sense of fullness
When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates production of insulin, as well as hormones such as C-peptide, Pyy, and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down.
While a graduate student at MIT, Srinivasan became interested in the idea of controlling this process by artificially stretching the mechanoreceptors that line the stomach, through vibration. Previous research had shown that vibration applied to a muscle can induce a sense that the muscle has stretched farther than it actually has.
“I wondered if we could activate stretch receptors in the stomach by vibrating them and having them perceive that the entire stomach has been expanded, to create an illusory sense of distension that could modulate hormones and eating patterns,” Srinivasan says.
As a postdoc in MIT’s Koch Institute for Integrative Cancer Research, Srinivasan worked closely with Traverso’s lab, which has developed many novel approaches to oral delivery of drugs and electronic devices. For this study, Srinivasan, Traverso, and a team of researchers designed a capsule about the size of a multivitamin, that includes a vibrating element. When the pill, which is powered by a small silver oxide battery, reaches the stomach, acidic gastric fluids dissolve a gelatinous membrane that covers the capsule, completing the electronic circuit that activates the vibrating motor.
In a study in animals, the researchers showed that once the pill begins vibrating, it activates mechanoreceptors, which send signals to the brain through stimulation of the vagus nerve. The researchers tracked hormone levels during the periods when the device was vibrating and found that they mirrored the hormone release patterns seen following a meal, even when the animals had fasted.
The researchers then tested the effects of this stimulation on the animals’ appetite. They found that when the pill was activated for about 20 minutes, before the animals were offered food, they consumed 40 percent less, on average, than they did when the pill was not activated. The animals also gained weight more slowly during periods when they were treated with the vibrating pill.
“The behavioral change is profound, and that’s using the endogenous system rather than any exogenous therapeutic. We have the potential to overcome some of the challenges and costs associated with delivery of biologic drugs by modulating the enteric nervous system,” Traverso says.
The current version of the pill is designed to vibrate for about 30 minutes after arriving in the stomach, but the researchers plan to explore the possibility of adapting it to remain in the stomach for longer periods of time, where it could be turned on and off wirelessly as needed. In the animal studies, the pills passed through the digestive tract within four or five days.
The study also found that the animals did not show any signs of obstruction, perforation, or other negative impacts while the pill was in their digestive tract.
An alternative approach
This type of pill could offer an alternative to the current approaches to treating obesity, the researchers say. Nonmedical interventions such as diet exercise don’t always work, and many of the existing medical interventions are fairly invasive. These include gastric bypass surgery, as well as gastric balloons, which are no longer used widely in the United States due to safety concerns.
Drugs such as GLP-1 agonists can also aid weight loss, but most of them have to be injected, and they are unaffordable for many people. According to Srinivasan, the MIT capsules could be manufactured at a cost that would make them available to people who don’t have access to more expensive treatment options.
“For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point,” she says. “I’d love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today.”
The researchers now plan to explore ways to scale up the manufacturing of the capsules, which could enable clinical trials in humans. Such studies would be important to learn more about the devices’ safety, as well as determine the best time to swallow the capsule before to a meal and how often it would need to be administered.
Written by Anne Trafton
Source: Massachusetts Institute of Technology
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