#diet capsule

[ketocareingredients]

Keto Care Reviews high light CBD Gummies Offer

Keto Care Reviews Scam and Legit How Does It Work Keto Care?

Are you tired of trying countless diets and weight loss methods with little to no results? If so, then you're not alone. Many people struggle to shed those extra pounds and achieve their ideal body shape. But fear not! There's a new solution on the market that's causing quite a buzz - Keto Care Reviews. In this blog post, we'll dive into the world of Keto Care Reviews and explore how it can help you reach your weight loss goals. We'll discuss its benefits, potential side effects, ingredients, and most importantly, how it works. So grab a cup of tea or coffee, sit back, relax, and let's uncover the secrets behind Keto Care Reviews!

😍👉 Good News: Keto Care Get additional discount on shipping when you checkout!,Click The Link Below to Get Started Now https://fitnessholt.com/keto-care-get-buy ✅

Keto Care - Try Them Today! Get Buy

What is the Keto Care Reviews?

Keto Care Reviews is a revolutionary weight loss supplement that has taken the health and fitness industry by storm. But what exactly is it? Keto Care Reviews is based on the popular ketogenic diet, which focuses on consuming low-carb, high-fat foods to put your body in a state of ketosis. When your body enters into ketosis, it starts burning stored fat for energy instead of relying on carbohydrates. This process can lead to rapid weight loss and increased energy levels. Keto Care Review aims to enhance this natural fat-burning process by providing your body with exogenous ketones. These exogenous ketones help jumpstart ketosis and keep you in that fat-burning zone for longer periods. In addition to aiding weight loss, Keto Care Reviews also supports mental clarity and focus while reducing cravings for unhealthy snacks. It's important to note that Keto Care Reviews is not a magic pill; it works best when combined with a balanced diet and regular exercise routine. It provides an extra boost along your weight loss journey, helping you achieve results faster than through dieting alone. So if you're ready to kick-start your metabolism, shed those unwanted pounds, and experience increased energy levels throughout the day, then perhaps it's time to give Keto Care Reviews a try!

BONUS OFFER |  GET The LOWEST Price from Official Website

Benefits of Keto Care Reviews?

Benefits of Keto Care Reviews 1. Weight Loss: One of the main benefits of using Keto Care Reviews is its ability to aid in weight loss. The ketogenic diet promotes a state of ketosis in the body, where it burns fat for energy instead of carbohydrates. By incorporating Keto Care Reviews into your routine, you can enhance this process and see faster results. 2. Increased Energy Levels: When following a low-carb diet like keto, some people may initially experience fatigue or low energy levels as their body adapts to using fat for fuel. However, with the help of Keto Care Reviews, you can boost your energy levels and avoid feeling sluggish during this transition phase. 3. Mental Clarity: Many users report improved mental clarity and focus when taking Keto Care Reviews supplements regularly. This could be attributed to the fact that ketones are an efficient source of fuel for the brain. 4. Appetite Control: Another benefit worth mentioning is appetite control. The high-fat content in a ketogenic diet combined with Keto Care Reviews' ability to suppress hunger cravings can make it easier to stick to your dietary goals and resist unhealthy snacking. 5. Metabolic Health: Research suggests that maintaining ketosis through products like Keto Care Reviews may have positive effects on metabolic health markers such as blood sugar levels and cholesterol profiles. Incorporating Keto Care Reviews into your keto journey can amplify these benefits and help you achieve your weight loss goals more effectively than relying solely on diet alone.

HUGE SAVINGS TODAY GET BEFORE STOCK RUNS OUT

Side Effects and Ingredients of Keto Care Reviews?

When it comes to any supplement, understanding the potential side effects and ingredients is crucial. Keto Care Reviews is no exception. Let's dive into what you need to know. Let's talk about the ingredients in Keto Care Reviews. This powerful formula contains a blend of natural ingredients that work together to support your keto journey. Some key ingredients include BHB ketones, MCT oil, green tea extract, and apple cider vinegar. These ingredients have been carefully selected for their ability to enhance fat burning, boost energy levels, and suppress appetite. As for Keto Care side effects, it's important to note that everyone's body reacts differently to supplements. While most people experience no adverse effects while taking Keto Care Reviews, some may experience minor digestive issues such as diarrhea or stomach discomfort during the initial adjustment period. It's always recommended to consult with a healthcare professional before starting any new supplement regimen. They can assess your individual needs and help determine if Keto Care Reviews is right for you. Remember that consistency is key when it comes to seeing results with any supplement or lifestyle change. Pairing Keto Care Reviews with a balanced diet and regular exercise can amplify its benefits and help you achieve your weight loss goals faster. Stay tuned for our next blog post where we will discuss how exactly Keto Care Reviews works!

EXCLUSIVE OFFER BUY FOR AN UN-BELIEVABLE LOW-PRICE TODAY

How Does it Work Keto Care Reviews?

Keto Care Reviews is a revolutionary weight loss supplement that utilizes the power of ketosis to help you shed those unwanted pounds. But how exactly does it work? Let's break it down. First and foremost, Keto Care Reviews contains BHB (Beta-Hydroxybutyrate) salts, which are essential in kickstarting the process of ketosis in your body. These powerful ingredients help your body enter a state where it burns fat for fuel instead of carbohydrates. When you consume carbs, your body typically converts them into glucose and uses that as its primary source of energy. However, when you restrict your carb intake while taking Keto Care Reviews, your body starts producing ketones from stored fat cells to use as fuel instead. This shift in energy production not only helps you burn off stubborn fat but also provides a steady supply of energy throughout the day. Plus, because fat is denser than carbs, you'll notice improved mental clarity and focus as well. Additionally, Keto Care Reviews helps suppress appetite by increasing serotonin levels in the brain. This can lead to reduced cravings and better control over portion sizes during meals. In combination with a healthy diet and regular exercise routine, Keto Care Reviews can greatly enhance weight loss results by promoting continuous fat burning without sacrificing muscle mass. So if you're looking for an effective way to achieve your weight loss goals with minimal effort, give Keto Care Reviews a try today!

Keto Care - Try Them Today! Get Buy

How Many Bottle Order Keto Care Reviews?

When it comes to ordering Keto Care Reviews, you have a few options to choose from. The manufacturer offers different packages that allow you to customize your order based on your needs. One option is to start with a single bottle of Keto Care Reviews. This is a great choice if you are new to the product and want to give it a try before committing to a larger order. It allows you to experience the benefits of Keto Care Reviews without making a big investment upfront. If you are ready for a longer-term commitment, there are also package deals available. You can opt for the "Buy 2, Get 1 Free" offer, which gives you three bottles of Keto Care Reviews at a discounted price. This is perfect if you plan on using the product consistently and want to save some money in the process. For those who really want to maximize their results and stock up on supply, there's an even bigger discount available when purchasing four or more bottles of Keto Care Reviews. This not only ensures that you won't run out anytime soon but also saves you even more money in the long run. No matter which option you choose, remember that consistency is key when taking any supplement. By following the recommended dosage instructions and sticking with your chosen package deal, you'll be well on your way towards achieving your health goals with Keto Care Reviews. To get started with your order of Keto Care Reviews today, simply visit their official website where all these options will be presented clearly for easy selection and purchase.

HUGE SAVINGS TODAY GET BEFORE STOCK RUNS OUT

Keto Care Reviews Where to Buy? If you're interested in trying out Keto Care for yourself, you may be wondering where you can purchase it. Unfortunately, Keto Care is not available in physical retail stores or on popular e-commerce platforms like Amazon. The only way to buy this product is through the official website. By purchasing directly from the manufacturer's website, you can ensure that you are getting a genuine and high-quality product. Additionally, buying from the official website gives you access to any ongoing promotions or discounts that may be available. To order Keto Care, simply visit the official website and fill out your information. You will then be directed to choose a package option based on your needs and preferences. After selecting your desired package, proceed to checkout and provide your payment details. It's important to note that ordering online comes with certain risks as well. There have been reports of counterfeit products being sold by unauthorized resellers on third-party websites. To avoid falling victim to scams or receiving fake products, always make sure to order directly from the official website. In conclusion, Keto Care Reviews has gained popularity among individuals who are looking for an effective way to support their ketogenic lifestyle. With its powerful blend of natural ingredients and potential benefits such as weight loss and increased energy levels, this supplement claims to help users achieve their health goals more efficiently. While there are positive reviews regarding Keto Care Reviews online, it's crucial to consult with a healthcare professional before starting any new dietary supplement regimen. Remember that individual results may vary, and it's essential not solely rely on supplements for weight loss or other health goals. Incorporating a balanced diet along with regular exercise is still key in achieving long-term success. So if you're considering giving Keto Care Reviews a try, do thorough research and consider consulting with professionals before making any decisions about using this product.

EXCLUSIVE OFFER BUY FOR AN UN-BELIEVABLE LOW-PRICE TODAY

😍👉 Good News: Keto Care Get additional discount on shipping when you checkout!,Click The Link Below to Get Started Now https://fitnessholt.com/keto-care-get-buy✅

✅✅ Keto Care Website + Top Deal: https://fitnessholt.com/keto-care-get-buy✅

✅✅ Keto Care Website + Top Deal: https://fitnessholt.com/keto-care-get-buy✅

[jcmarchi]

Engineers develop a vibrating, ingestible capsule that might help treat obesity

New Post has been published on https://thedigitalinsider.com/engineers-develop-a-vibrating-ingestible-capsule-that-might-help-treat-obesity/

Engineers develop a vibrating, ingestible capsule that might help treat obesity

When you eat a large meal, your stomach sends signals to your brain that create a feeling of fullness, which helps you realize it’s time to stop eating. A stomach full of liquid can also send these messages, which is why dieters are often advised to drink a glass of water before eating.

MIT engineers have now come up with a new way to take advantage of that phenomenon, using an ingestible capsule that vibrates within the stomach. These vibrations activate the same stretch receptors that sense when the stomach is distended, creating an illusory sense of fullness.

In animals who were given this pill 20 minutes before eating, the researchers found that this treatment not only stimulated the release of hormones that signal satiety, but also reduced the animals’ food intake by about 40 percent. Scientists have much more to learn about the mechanisms that influence human body weight, but if further research suggests this technology could be safely used in humans, such a pill might offer a minimally invasive way to treat obesity, the researchers say.

“For somebody who wants to lose weight or control their appetite, it could be taken before each meal,” says Shriya Srinivasan PhD ’20, a former MIT graduate student and postdoc who is now an assistant professor of bioengineering at Harvard University. “This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there.”

Srinivasan is the lead author of the new study, which appears today in Science Advances. Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital, is the senior author of the paper.

A sense of fullness

When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates production of insulin, as well as hormones such as C-peptide, Pyy, and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down.

While a graduate student at MIT, Srinivasan became interested in the idea of controlling this process by artificially stretching the mechanoreceptors that line the stomach, through vibration. Previous research had shown that vibration applied to a muscle can induce a sense that the muscle has stretched farther than it actually has.

“I wondered if we could activate stretch receptors in the stomach by vibrating them and having them perceive that the entire stomach has been expanded, to create an illusory sense of distension that could modulate hormones and eating patterns,” Srinivasan says.

As a postdoc in MIT’s Koch Institute for Integrative Cancer Research, Srinivasan worked closely with Traverso’s lab, which has developed many novel approaches to oral delivery of drugs and electronic devices. For this study, Srinivasan, Traverso, and a team of researchers designed a capsule about the size of a multivitamin, that includes a vibrating element. When the pill, which is powered by a small silver oxide battery, reaches the stomach, acidic gastric fluids dissolve a gelatinous membrane that covers the capsule, completing the electronic circuit that activates the vibrating motor.

In a study in animals, the researchers showed that once the pill begins vibrating, it activates mechanoreceptors, which send signals to the brain through stimulation of the vagus nerve. The researchers tracked hormone levels during the periods when the device was vibrating and found that they mirrored the hormone release patterns seen following a meal, even when the animals had fasted.

The researchers then tested the effects of this stimulation on the animals’ appetite. They found that when the pill was activated for about 20 minutes, before the animals were offered food, they consumed 40 percent less, on average, than they did when the pill was not activated. The animals also gained weight more slowly during periods when they were treated with the vibrating pill.

“The behavioral change is profound, and that’s using the endogenous system rather than any exogenous therapeutic. We have the potential to overcome some of the challenges and costs associated with delivery of biologic drugs by modulating the enteric nervous system,” Traverso says.

The current version of the pill is designed to vibrate for about 30 minutes after arriving in the stomach, but the researchers plan to explore the possibility of adapting it to remain in the stomach for longer periods of time, where it could be turned on and off wirelessly as needed. In the animal studies, the pills passed through the digestive tract within four or five days.

The study also found that the animals did not show any signs of obstruction, perforation, or other negative impacts while the pill was in their digestive tract.

An alternative approach

This type of pill could offer an alternative to the current approaches to treating obesity, the researchers say. Nonmedical interventions such as diet exercise don’t always work, and many of the existing medical interventions are fairly invasive. These include gastric bypass surgery, as well as gastric balloons, which are no longer used widely in the United States due to safety concerns.

Drugs such as GLP-1 agonists can also aid weight loss, but most of them have to be injected, and they are unaffordable for many people. According to Srinivasan, the MIT capsules could be manufactured at a cost that would make them available to people who don’t have access to more expensive treatment options.

“For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point,” she says. “I’d love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today.”

The researchers now plan to explore ways to scale up the manufacturing of the capsules, which could enable clinical trials in humans. Such studies would be important to learn more about the devices’ safety, as well as determine the best time to swallow the capsule before to a meal and how often it would need to be administered.

Other authors of the paper include Amro Alshareef, Alexandria Hwang, Ceara Byrne, Johannes Kuosmann, Keiko Ishida, Joshua Jenkins, Sabrina Liu, Wiam Abdalla Mohammed Madani, Alison Hayward, and Niora Fabian.

The research was funded by the National Institutes of Health, Novo Nordisk, the Department of Mechanical Engineering at MIT, a Schmidt Science Fellowship, and the National Science Foundation.

[farhankhan12]

Unlock Your Fitness Goals: Exploring the Power of Slimming Capsules for Women

In today's fast-paced world, maintaining a healthy lifestyle can be challenging, especially for women juggling multiple responsibilities. The desire to achieve and maintain a fit and toned physique is a common goal for many women. While regular exercise and a balanced diet are essential, there are additional tools available to support women in their fitness journeys. Fitness slimming capsules for women have gained popularity as a potential aid in weight management and achieving fitness goals. In this article, we will delve into the power of slimming capsules for women and explore their benefits and considerations. 

At Couplehealthcare, we understand the importance of women's health and well-being, offering a range of slimming capsules designed specifically to assist women in their pursuit of a healthier lifestyle.

Understanding Slimming Capsules 

1.1 What are Slimming Capsules?

Slimming capsules, also known as weight loss supplements, are dietary supplements formulated to assist in weight management and promote fat loss. These capsules typically contain a combination of natural ingredients that work synergistically to support various aspects of weight management.

1.2 How Do Slimming Capsules Work?

Slimming capsules work through different mechanisms. Some capsules help boost metabolism, allowing the body to burn more calories efficiently. Others may suppress appetite, reducing cravings and overeating. Some slimming capsules may also inhibit the absorption of dietary fats, thereby reducing calorie intake.

1.3 Ingredients in Slimming Capsules

The ingredients in slimming capsules can vary depending on the product. Common ingredients include green tea extract, caffeine, garcinia cambogia, forskolin, and various vitamins and minerals. These ingredients are carefully selected for their potential benefits in weight management.

1.4 Safety and Regulations

It's essential to choose slimming capsules from reputable manufacturers who adhere to strict quality and safety standards. Look for products that have been tested and approved by regulatory authorities. It's also crucial to follow the recommended dosage and consult with a healthcare professional before starting any new dietary supplement.

The Benefits of Slimming Capsules for Women 

2.1 Weight Management and Fat Loss

Slimming capsules can support weight management efforts by boosting metabolism and promoting fat burning. When combined with exercise and a balanced diet, these capsules can help women achieve their weight loss goals more effectively. You can buy slimming capsules from the Couplehealthcare website.

2.2 Increased Energy and Metabolism

Many slimming capsules contain ingredients like caffeine and green tea extract, which can increase energy levels and enhance metabolism. This can provide women with the energy they need to stay active and engage in regular exercise routines.

2.3 Appetite Suppression

One of the challenges in weight management is controlling appetite and cravings. Slimming capsules often include appetite-suppressing ingredients that can help reduce the desire to overeat, making it easier to stick to a calorie-controlled diet.

2.4 Mood and Mental Well-being

Weight loss journeys can be emotionally challenging. Some slimming capsules contain ingredients that support mood and mental well-being, helping women stay motivated and focused on their goals.

2.5 Hormonal Balance

Hormonal imbalances can affect weight management in women. Certain slimming capsules are formulated to help regulate hormones, such as cortisol and insulin, which can influence fat storage and metabolism.

Choosing the Right Slimming Capsules 

3.1 Assessing Individual Needs and Goals

Before selecting a slimming capsule, it's crucial to assess individual needs and weight loss goals. Consider factors such as current weight, body composition, overall health, and any pre-existing conditions.

3.2 Reading Labels and Understanding Product Claims

Carefully read the labels of slimming capsules and understand the product claims. Look for scientific evidence or clinical studies supporting the effectiveness of the ingredients. Avoid products that make exaggerated claims without substantial evidence.

3.3 Researching Product Reputation and Customer Reviews

Do thorough research on the reputation of the brand and the specific slimming capsule you're considering. Read customer reviews and testimonials to get insights into other users' experiences with the product.

3.4 Consulting with Healthcare Professionals

Consult with a healthcare professional, such as a registered dietitian or a physician, before incorporating slimming capsules into your routine. They can provide personalized advice and ensure the product is safe and suitable for you.

Incorporating Slimming Capsules into Your Fitness Routine 

4.1 Pairing Slimming Capsules with Exercise

Slimming capsules can complement an exercise routine by providing energy and enhancing fat burning. Combine the capsules with a well-rounded exercise program that includes cardiovascular exercises and strength training for optimal results.

4.2 Combining Slimming Capsules with a Balanced Diet

Remember that slimming capsules are not a substitute for a healthy diet. Pair the capsules with a balanced, nutrient-dense eating plan that includes plenty of fruits, vegetables, lean proteins, whole grains, and healthy fats.

4.3 Establishing Realistic Expectations

While slimming capsules can support weight loss efforts, it's important to set realistic expectations. Healthy and sustainable weight loss is typically around 1-2 pounds per week. Avoid falling into the trap of quick-fix solutions or unrealistic promises.

4.4 Monitoring Progress and Adjusting Dosage

Regularly monitor your progress and adjust the dosage of slimming capsules as necessary. Pay attention to any changes in weight, body measurements, energy levels, and overall well-being. If needed, consult with a healthcare professional for guidance.

Precautions and Considerations 

5.1 Potential Side Effects

Although slimming capsules are generally safe, some individuals may experience side effects. These can include gastrointestinal discomfort, increased heart rate, jitteriness, or allergic reactions. If any adverse effects occur, discontinue use and consult a healthcare professional.

5.2 Allergies and Sensitivities

Check the ingredient list of slimming capsules for any known allergies or sensitivities. If you have a history of allergies, carefully review the composition to ensure there are no potential triggers.

5.3 Pregnancy and Breastfeeding

Pregnant or breastfeeding women should avoid slimming capsules, as their safety during these periods is not well-established. Focus on maintaining a healthy diet and engaging in appropriate exercises under the guidance of a healthcare professional.

5.4 Interactions with Medications

If you are taking any medications, including prescription drugs or over-the-counter supplements, consult with a healthcare professional before starting slimming capsules. Some ingredients may interact with certain medications, affecting their efficacy or causing adverse effects.

5.5 Maintaining a Healthy Lifestyle

Remember that slimming capsules are just one part of a comprehensive approach to weight management. It's important to adopt and maintain a healthy lifestyle that includes regular physical activity, a balanced diet, adequate sleep, and stress management.

Conclusion 

In conclusion, fitness slimming capsules for women can be a valuable tool for looking to unlock their goals and achieve a healthier lifestyle. When used in conjunction with regular exercise and a balanced diet, these capsules can enhance weight management efforts, boost energy levels, suppress appetite, improve mood, and support hormonal balance. However, it is crucial to choose high-quality products, conduct thorough research, and consult with healthcare professionals before incorporating slimming capsules into your fitness routine. At Couplehealthcare, we are committed to providing safe and effective slimming capsules tailored to women's specific needs. Remember, achieving your fitness goals is a journey, and taking small, sustainable steps is key to long-term success.

[tocura]

The pharmaceutical industry is an essential sector that plays a significant role in ensuring the health and well-being of individuals across the world. In recent years, Pharma Manufacturers in Turkey has emerged as a prominent player in the global pharma market. With its pharmaceutical manufacturers gaining increasing recognition for their quality products and competitive prices.

[sudsrunner01]

Stressomed is the ultimate solution for those looking to alleviate stress and anxiety in their lives. Available on tocura.com.tr, Stressomed is a natural remedy designed to promote relaxation and calmness, helping individuals manage their stress levels effectively. With Stressomed, you can say goodbye to stress and embrace a more peaceful state of mind.

[gofitnesspro]

Vitamin E: Symptoms of Deficiency

Vitamin E deficiency is relatively rare but can occur in certain situations, particularly when fat absorption is impaired or in individuals with specific genetic conditions. Here are some common symptoms and signs of E vitamin deficiency: Vitamin E: Neurological Problems Peripheral Neuropathy: Damage to the peripheral nerves causing numbness, tingling, and weakness, particularly in the hands…

[nikhalgupta]

Indulge the Use of Ayurvedic Weight Loss Capsules in Delhi

Ayurvedic weight loss capsules in Delhi are the basic supplements that are used to reduce extra fat and metabolism from the human body. The main function of Ayurvedic weight loss capsules boosting metabolism, aiding digestion, and helping the body fat burn more effectively. These Ayurvedic Weight Loss Capsules in Delhi are available in the local market and also available online as well. They are very gentle and follow the traditional way of Ayurvedic Medication that cuts down heavy pounds while taking care of your complete health.

[health-supplementproducts]

NightDry Supplements - Health

NightDry Supplements: A Rescuer for Restless Nights!

For years, I was plagued by nightly visits to the loo. Disrupted sleep, a grumpy disposition by morning, and the constant worry of leaks – it was a right nightmare! I tried various things – cutting out fluids before bed, bladder exercises, even a particularly fetching adult nappy (not recommended!). Nothing seemed to work. Then, a friend recommended NightDry, and let me tell you, it's been a game-changer!

Sweet Dreams, No More Alarms

Since taking NightDry, those nightly treks to the bathroom are a thing of the past. I can finally sleep through the night without interruption. This has made a world of difference to my energy levels. No more dragging myself out of bed feeling like a deflated balloon! I wake up feeling refreshed and ready to tackle the day.

Confidence Boost and Social Fun Restored

The constant worry about leaks had me avoiding social gatherings and outings. I wouldn't dare go for a long walk or even a trip to the cinema for fear of an embarrassing accident. NightDry has given me back my confidence. Now, I can enjoy evenings out with friends and family without a care in the world.

Natural Ingredients, Natural Relief

I was a little apprehensive at first about taking a supplement, but what convinced me about NightDry was the fact it contains all-natural ingredients. There are no harsh chemicals or mystery additives, just a blend of herbs and vitamins formulated to support healthy bladder function. It's reassuring to know I'm not putting anything nasty into my body.

Discretion and Convenience

NightDry comes in discreet packaging, so there's no need to feel embarrassed about having it delivered. The tablets themselves are small and easy to swallow, and I only need to take one a day. It's a simple and convenient way to manage my nighttime needs.

A Brighter Outlook

NightDry has honestly improved my quality of life. I'm no longer a slave to my bladder, and I can finally sleep soundly through the night. If you're experiencing similar issues, I urge you to give NightDry a try. It might just be the answer you've been searching for!

[tocura]

Find restful sleep and claim your mind with TRELEST- your natural solution for stress and insomnial

[getfitgoodvibes]

Sea Moss Capsules - Vital Nutrients | GFGV

[gudfitayurveda]

Me-Shield Immunity Booster Syrup and Capsule

Boost Immune System Helps to Rejuvenate Mind and Body Fights Against Respiratory Complaints Holds Liver Detoxification Properties

Helpline Number - 96371-58000

[jcmarchi]

Engineers develop a vibrating, ingestible capsule that might help treat obesity - Technology Org

New Post has been published on https://thedigitalinsider.com/engineers-develop-a-vibrating-ingestible-capsule-that-might-help-treat-obesity-technology-org/

Engineers develop a vibrating, ingestible capsule that might help treat obesity - Technology Org

When you eat a large meal, your stomach sends signals to your brain that create a feeling of fullness, which helps you realize it’s time to stop eating. A stomach full of liquid can also send these messages, which is why dieters are often advised to drink a glass of water before eating.

MIT engineers designed an ingestible capsule that vibrates within the stomach, creating an illusory sense of fullness and reducing appetite. The pill could offer a minimally invasive, cost-effective way to treat obesity. Illustration by the researchers, MIT News

MIT engineers have now come up with a new way to take advantage of that phenomenon, using an ingestible capsule that vibrates within the stomach. These vibrations activate the same stretch receptors that sense when the stomach is distended, creating an illusory sense of fullness.

In animals who were given this pill 20 minutes before eating, the researchers found that this treatment not only stimulated the release of hormones that signal satiety, but also reduced the animals’ food intake by about 40 percent. Scientists have much more to learn about the mechanisms that influence human body weight, but if further research suggests this technology could be safely used in humans, such a pill might offer a minimally invasive way to treat obesity, the researchers say.

“For somebody who wants to lose weight or control their appetite, it could be taken before each meal,” says Shriya Srinivasan PhD ’20, a former MIT graduate student and postdoc now an assistant bioengineering professor at Harvard University. “This could be really interesting in that it would provide an option that could minimize the side effects that we see with the other pharmacological treatments out there.”

Srinivasan is the new study’s lead author, which appears in Science Advances. Giovanni Traverso, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital, is the paper’s senior author.

A sense of fullness

When the stomach becomes distended, specialized cells called mechanoreceptors sense that stretching and send signals to the brain via the vagus nerve. As a result, the brain stimulates production of insulin, as well as hormones such as C-peptide, Pyy, and GLP-1. All of these hormones work together to help people digest their food, feel full, and stop eating. At the same time, levels of ghrelin, a hunger-promoting hormone, go down.

While a graduate student at MIT, Srinivasan became interested in the idea of controlling this process by artificially stretching the mechanoreceptors that line the stomach, through vibration. Previous research had shown that vibration applied to a muscle can induce a sense that the muscle has stretched farther than it actually has.

“I wondered if we could activate stretch receptors in the stomach by vibrating them and having them perceive that the entire stomach has been expanded, to create an illusory sense of distension that could modulate hormones and eating patterns,” Srinivasan says.

As a postdoc in MIT’s Koch Institute for Integrative Cancer Research, Srinivasan worked closely with Traverso’s lab, which has developed many novel approaches to oral delivery of drugs and electronic devices. For this study, Srinivasan, Traverso, and a team of researchers designed a capsule about the size of a multivitamin, that includes a vibrating element. When the pill, which is powered by a small silver oxide battery, reaches the stomach, acidic gastric fluids dissolve a gelatinous membrane that covers the capsule, completing the electronic circuit that activates the vibrating motor.

In a study in animals, the researchers showed that once the pill begins vibrating, it activates mechanoreceptors, which send signals to the brain through stimulation of the vagus nerve. The researchers tracked hormone levels during the periods when the device was vibrating and found that they mirrored the hormone release patterns seen following a meal, even when the animals had fasted.

The researchers then tested the effects of this stimulation on the animals’ appetite. They found that when the pill was activated for about 20 minutes, before the animals were offered food, they consumed 40 percent less, on average, than they did when the pill was not activated. The animals also gained weight more slowly during periods when they were treated with the vibrating pill.

“The behavioral change is profound, and that’s using the endogenous system rather than any exogenous therapeutic. We have the potential to overcome some of the challenges and costs associated with delivery of biologic drugs by modulating the enteric nervous system,” Traverso says.

The current version of the pill is designed to vibrate for about 30 minutes after arriving in the stomach, but the researchers plan to explore the possibility of adapting it to remain in the stomach for longer periods of time, where it could be turned on and off wirelessly as needed. In the animal studies, the pills passed through the digestive tract within four or five days.

The study also found that the animals did not show any signs of obstruction, perforation, or other negative impacts while the pill was in their digestive tract.

An alternative approach

This type of pill could offer an alternative to the current approaches to treating obesity, the researchers say. Nonmedical interventions such as diet exercise don’t always work, and many of the existing medical interventions are fairly invasive. These include gastric bypass surgery, as well as gastric balloons, which are no longer used widely in the United States due to safety concerns.

Drugs such as GLP-1 agonists can also aid weight loss, but most of them have to be injected, and they are unaffordable for many people. According to Srinivasan, the MIT capsules could be manufactured at a cost that would make them available to people who don’t have access to more expensive treatment options.

“For a lot of populations, some of the more effective therapies for obesity are very costly. At scale, our device could be manufactured at a pretty cost-effective price point,” she says. “I’d love to see how this would transform care and therapy for people in global health settings who may not have access to some of the more sophisticated or expensive options that are available today.”

The researchers now plan to explore ways to scale up the manufacturing of the capsules, which could enable clinical trials in humans. Such studies would be important to learn more about the devices’ safety, as well as determine the best time to swallow the capsule before to a meal and how often it would need to be administered.

Written by Anne Trafton

Source: Massachusetts Institute of Technology

You can offer your link to a page which is relevant to the topic of this post.

[nikhalgupta]

iVate Ayurveda offers the Best Deals of Ayurvedic Weight Gainer Capsules for Delhi just Rs.1299/- only!

[magicpotions123]

Get healthtone gain capsulse

Healthtone gain capsules are emerging as a prominent choice for individuals looking to naturally enhance their body weight. As one of the top-rated weight gain supplements, these capsules offer a blend of natural ingredients that act as appetite enhancers, ensuring users intake more calories, which is vital for weight gain. One of the major Healthtone capsules benefits is that they are not just about adding numbers on the scale; they focus on muscle mass enhancement. Being a dietary supplement for weight, they ensure the weight you gain is healthy and not just fat accumulation.