#conceptual biology

[kismetmoon]

thinking about concepts with exwhylians’ third dimensional forms and / or flatland lines’ intermediate forms when converting from 2D to 3D bodies,,

[ID: five traditional black ink doodles of concepts for Exwhylian lines and shapes from Gravity Falls, all on beige paper backgrounds.

In the first image, an Exwhylian line is shown. It has a thin body shaped like an upside-down tuning fork, with thin pointed feet and a long torso. It also has a long thing tail with a star on the end. It has a star-shaped head with one blank eye. It is stood upright and slighting smiling.

In the first image, it is a line similar to the one in the first image, except is feet are more rounded and it has a raindrop-shaped symbol on the end of its tail. It is standing and tailoring its head to the left. Its feet are held close together and its tail is curled out to the left side.

In the third image, it is a line wearing a large triangular cloak. It has a circular head with a larger blank eye, a small point on top of its head, triangular eyelashes at either side of its head, thicker pointed feet and a plain tail. It is standing facing the viewer with no expression and its tail can be seen peeking out from under its cloak on the right.

In the fourth image, it is a line with a similar body shape to the one shown in the first image, but it has small hooks on its feet. It has the same tail as the line in the second image. Its head is a circle with another circle around it, a sharp point on top and a blank eye. It is posed as though it is hobbling along, titling its head over to the left.

In the fifth image, it shows a line and an isosceles triangle sitting together. The line has a larger circular head with a small eye and a similar body to the above described line. The isosceles has a black body, a long tail with a flame-shaped end, a circular blank eye and stubby legs.

End ID].

[chiiroptereh]

Went on a mushroom trip on New Years, saw this random image on my phone and it spoke to me. He is like a deep sea organism comb jelly copepod looking thing to me

Always so fascinated by my shroomy art, it's somehow even more colorful than usual and looks nothing like how it was supposed to, lol! Definitely going in my wallpapers folder

[unopenablebox]

relatedly today the british coworker i have an only maybe disproportionate grudge against learned which six flags are the six flags and as the rest of my labmates groaned in horror he was like "well... it's part of the history though" and like. listen. i know you haven't lived in the US before. but when the room universally reacts in horror at something they think is racist possibly you should ask any questions you may have about it in "question" rather than "immediate defense of the confederate flag" format

[amadillo96]

Personal Kn8 USAKDF ideas.

Weapons+ kaiju-fication

this ties into my theoretical US AKDF post, btw. (This is super unfocused lol.) Here

First up, I'm gonna say I based this on my idea of a US AKDF that uses Kaiju-Hybridization cause it's cool. Though this will be partially focused around a singular character of mine bc I'm going to be packing a lot of lore into each section.

Character Idea

Who've I've affectionately codenamed Los Angeles. They're the one with the "mech-suit".

Personally, I've decided to base their abilities and Kaiju features around ✨️Salamanders✨️. I'd also imagine that each kaiju-hybrid soldier would have a kind of animal theme since the kaiju in kn8 also tend to have animal or plant themes.

Primarily around the toxins that they secrete as a defense mechanism. The kaiju-ification process creating a uni-organ capable of secreting slime or some form of lubricant that could them be used like venom. Injected into the target through a weapon.

Ignore the fact that this is of a newt.

Los Angeles, as a character, would function as a platoon leader and tactician for their group. While remaining rather headstrong and aggressive. So I gave them a mech suit!

Though. Not quite Pacific Rim style, I was more-so inspired by the suits from HALO. A heavy armor that would include mechanical aspects, though would be light enough to maintain a high-speed, aggressive fighting style. Using both aspects of grappling martial arts and rope weapons!

I'd also imagine their kaiju features to include a big old tail. So, a mech-suit would help hide their more inhuman features underneath the layers of armor.

Meteor hammer from Ancient China.

Though the rope weaponry is where an interesting thing could occur. By utilizing something like poisonous secretions alongside a bladed weapon, it would act like a venom!

My current idea for a longer ranged weapon would be a meteor hammer mixed with something like a portable hand saw. A rugged edge that could be swung around like a meteor hammer, with the armor preventing damage against its own user. When coming in contact, it acts as a saw, tearing through enemy flesh, and also administering the poison in tandem.

Kaiju-ification

Though realistically, it doesn't make much sense for a suit of heavy armor to be on a lightweight fighter. The reason I chose this was bc of the kaiju-ification process I had in mind for how the platoons of the US AKDF's "kaiju force" would be created. (Chapter 58)

The current in lore explanation of what creates kaiju.

This process would be utilizing kaiju's natural ability of regeneration to create a parasitic/symbiotic relation between a host human body and the tissue of a kaiju. I'd imagine that to avoid any legal issues dealing with the humaneness of using live human subjects, it'd be found better to use people who would be "unsalvagable" people in vegetative comas and such. Where there is no expectation of a quality of life.

This blank body would then be tested for "cell compatability," much like the number weapon users of the JAKDF. Though, since I'd imagine these trials would be much more diverse in kaiju used, there would be a fair bit of people who'd end up compatable with the kaiju cells. (Chapter 58)

The cells would be implanted, and the body would be left to allow the kaiju's near-cancerous like abilities to regenerate. The best 'batches' of experiments then going on to be trained and rehabilitated into soldiers.

It'd allow all kinds of fun shenanigans as characters who've undergone this process would essentially be stuck in a Kafka-esk scenario. Fighting biological kaiju influences while maintaining a human appearance. Possibly exacerbated depending on how human the process leaves them. ✨️✨️

Something similar to how Narumi's number suit works. Though I'm pretty sure the implanted eyes are a fan theory, they've heavily inspired my ideas of how Kaiju tissue interacts with people.

(Theory stemming from the difference between Narumi's eyes as a teenager vs. his current eyes.)

I also like to think of the process actively creating Kaiju more like a cancer than an evolutionary process.

Since it is influenced by outside phenomena and happens in the short term.

[aut2imagineart]

Between my busy work schedule, family vacation, and my laptop being worked on, I haven't been able to work on as much artwork as I would like though I was able to make a neat story panel for a client that I'll be posting soon.  In the meantime, I wanted to create a quick concept sketch of a creature that I plan to include in a future project, specifically the next installation of my Pangea Ultima speculative evolution project.

As always, comments and critiques are welcome.

[cloudgremlin]

Gotta love neurodivergent interests I was laying and thinking about my newest brain story which is my tmnt au and like this just goes 24/7 in my brain now, I can barely remember what it replaced, I think before the tmnt brainrot it was a Completely Not Built Just For A Single DnD Character worldbuild and before that, who knows, there’s always Some story up there that I am constantly building and putting under a microscope and Researching and microwaving to see what happens, this is just what the brain do when you’re autistic and have a special interest in storytelling I guess ¯\_(ツ)_/¯

[artvalve]

tryna have a productive convo with a trans skeptic gets infinitely more tedious when you speak a language where the word for sex and gender are one and the same

[straynoahide]

by god i love old scientific works

Y’ever read something and have understanding that has eluded you interminably suddenly stop, curl up, and snuggle neatly into a fold in your brain because a new way way opened to it?

[grecoromanyaoi]

the whole thing abt hermaphroditus specifically resting hermaphroditus is that ur supposed to walk around it and think 'oh pretty woman.... wait. PENIS???' which in our day at least dabbling in transmisogyny, if im being gentle. bc in our modern minds, that's a trans womans body. we know there r women who look like this. dare i say most ppl in the world know that there r women who look like this, even if only in theory, even if they dont consider them women.

however that was not the case in ancient times. before hrt and gender affirming surgeries, trans women didnt look like that. to them it was not a trans woman's body, it was an intersex body, and afaik someone being this "visually" intersex is EXTREMELY rare. it was so rare, they never even heard of anyone who looks like this irl. so rare and unexplained, so "unnatural" to the way they see the world, that it might as well be mythological. a figure that exists due to cosmic events, not bc of the inherent diversity of human biology.

its just so crazy to me that to the ppl who worshipped her n painted her n drew her n the original intended audience could only conceptualize her as an otherworldly mythical figure and to most ppl today who r even somewhat involved in popular culture or the trans community shes just like. a normal woman. we look at her and go 'yeah this celebrity/my friend/my girlfriend/i look like this'. isnt it amazing??

anyways i was in palazzo massimo today and they had a resting hermaphroditus properly placed within the space thank GAWD so here she is

[debutart]

“Biology” by Sam Green for Foreign Affairs Magazine.

[kismetmoon]

More exshylians design!!

Very pretty,very beautiful😭

aw, i’m glad that you like them !

i’m definitely going to make more of these guys in the future, they’re so fun to draw. but here’s my first run down on their adapted biology and basic body plan for exploring a new dimension in the meantime :)

[ID: a traditional black ink pen drawing of an Exwhylian line, an original conceptual character from Gravity Falls.

It has a round head with a white eye without a pupil and a small sharp point on top. Its body is black and thin, with no arms and two spindly legs that end in small fat hooks. It also has a thin curved tail.

It is stood facing the viewer directly with its tail behind it. There is text at either side of it. At the top left the text says “no pupil yet. eliminates potential seizures”. At the bottom left it says “adapted long hooked cilia (akin to spider legs) to allow all terrain and anti-gravitational movement”. On the right is says “still retains basic line body plan on top half” and “single extended cilium now acts as a pseudopod and aids in balance”.

End ID].

also i left just the body plan without any text under the cut :

[ID: the same image as above, but with no text. End ID].

[foldingfittedsheets]

A basic human skill that people usually lock down around the age of three or four is impulse control. To conceptualize an action and it’s consequences before taking it. Maybe considering how that action affects other people. We then refine it through most of our childhood.

When I was a teenager my hold on this ability became… tenuous. I became a volatile and dangerous creature.

It’s probably not unique to me, but I had a perfect storm in terms of mental upsets. I had just mastered enough basic social skills, so I finally had a strong group of friends when my dad suddenly needed to move for work. Ripped away from my support network, blooming with hormones, I was dragged to Arizona. I was always a child of forests and mist and suddenly everything was hot, dry, and extremely pointy and aggressive.

Additionally to being abruptly transplanted I found myself an object of affection in a way I’d never been before. Lonely and desperate to make friends the only people who wanted to spend time with me had romantic designs. I just wanted to figure out my shit but I had a baby lesbian flirting with increasing aggression in art, a soft boy making heart eyes at me in biology, a senior nerd asking if I wanted to play Halo at his house and could he hold my hand?

Reader, I snapped. I didn’t want this romantic attention but I also didn’t want to be alone. My brain coped the only way it knew how, by simply cutting out decision making. Any action was the right action to take.

It started with the boy in biology. I’d stolen his pencil out of mischief and to my overwhelming fury instead of trying to steal it back he just softened his eyes and chucked me gently under my chin, a gesture so overtly sweet and romantic that I saw red.

I stabbed him with his own pencil.

I honestly and truly have no memory of it. It happened as fast as a snake striking and I was instantly filled with terrified remorse. Unfortunately that manifested as psychotic giggling.

“I’m so sorry, I didn’t- I don’t know why- I’m so sorry!” I said, while hysterically laughing. I ended up having lodged some graphite in his palm and had to tweeze it out with my nails while apologizing furiously. (It’s very important to note here that he forgave me and we’re still friends)

That was weird, I thought. Why didn’t I think before I stabbed someone?

The next event was equally catastrophic, and I had even less reason to do it. In gym with two girls I was tentatively befriending, we were warming up running laps. I started racing one of them. At breakneck speed we were sprinting around the gym.

This time, there was a blip of thought before I fucked up. I should get the other girl! I have no idea why or what the plan was but I turned on a swivel and body checked the other girl. We both fell down in immense pain. I think that’s the moment I broke my tailbone. Her knees were horribly bruised and she looked at me in bewildered pain. “Why did you do that?!”

I had no idea. I apologized and helped her up, both of us hobbling like newborn horses, bruised and hurting.

By this time there’d been enough social upheavals that I was reduced to spending time with some girls I had nothing in common with and low key disliked. Sat at a table listening to this girl talk about how she wanted to be a stripper when she grew up I thought, You’d better put the cap on before you throw it.

I then chucked my empty water bottle directly at her face. It bounced off her forehead with a bop! that would have made a sound mixer weep at its perfection.

All eyes turned to me is startlement. I stared back at her, stunned by my own action, just as confused as everyone else at the table as to why I’d done that. One of the girls to my right said, “Were you trying to hit that fly?”

“Yes!” I lied, “I’m sorry, I thought I could hit the fly!”

Everyone laughed at my antics and I joined in rather than admit I had just chucked something at her for no reason.

Things did start to improve after that. I solidified a friendship with the girl I’d raced (who I developed a massive crush on and ten years later would go on to date). My outbursts turned more whimsical rather than aggressive. Like accosting a girl leaving the cafeteria to look deeply into her eyes and say with great compassion, “It’s going to be alright.”

My new friend and I snuck into the van that delivered our cafeterias baked goods and lay giggling in the back. When I’d impulsively hopped in she’d joined me and made it a game.

After a year in Arizona I broke down crying to my mother, an act of great desperation, and we ended up moving back home. My impulse control returned to normal teenage levels and life resumed in a happier state of mind.

[reasonsforhope]

"A team at Northwestern University has come up with the term “dancing molecules” to describe an invention of synthetic nanofibers which they say have the potential to quicken the regeneration of cartilage damage beyond what our body is capable of.

The moniker was coined back in November 2021, when the same team introduced an injection of these molecules to repair tissues and reverse paralysis after severe spinal cord injuries in mice.

Now they’ve applied the same therapeutic strategy to damaged human cartilage cells. In a new study, published in the Journal of the American Chemical Society, the treatment activated the gene expression necessary to regenerate cartilage within just four hours.

And, after only three days, the human cells produced protein components needed for cartilage regeneration, something humans can’t do in adulthood.

The conceptual mechanisms of the dancing molecules work through cellular receptors located on the exterior of the cell membrane. These receptors are the gateways for thousands of compounds that run a myriad of processes in biology, but they exist in dense crowds constantly moving about on the cell membrane.

The dancing molecules quickly form synthetic nanofibers that move according to their chemical structure. They mimic the extracellular matrix of the surrounding tissue, and by ‘dancing’ these fibers can keep up with the movement of the cell receptors. By adding biological signaling receptors, the whole assemblage can functionally move and communicate with cells like natural biology.

“Cellular receptors constantly move around,” said Northwestern Professor of Materials Sciences Samuel Stupp, who led the study. “By making our molecules move, ‘dance’ or even leap temporarily out of these structures, known as supramolecular polymers, they are able to connect more effectively with receptors.”

The target of their work is the nearly 530 million people around the globe living with osteoarthritis, a degenerative disease in which tissues in joints break down over time, resulting in one of the most common forms of morbidity and disability.

“Current treatments aim to slow disease progression or postpone inevitable joint replacement,” Stupp said. “There are no regenerative options because humans do not have an inherent capacity to regenerate cartilage in adulthood.”

In the new study, Stupp and his team looked to the receptors for a specific protein critical for cartilage formation and maintenance. To target this receptor, the team developed a new circular peptide that mimics the bioactive signal of the protein, which is called transforming growth factor beta-1 (TGFb-1).

Northwestern U. Press then reported that the researchers incorporated this peptide into two different molecules that interact to form supramolecular polymers in water, each with the same ability to mimic TGFb-1...

“With the success of the study in human cartilage cells, we predict that cartilage regeneration will be greatly enhanced when used in highly translational pre-clinical models,” Stupp said. “It should develop into a novel bioactive material for regeneration of cartilage tissue in joints.”

“We are beginning to see the tremendous breadth of conditions that this fundamental discovery on ‘dancing molecules’ could apply to,” Stupp said. “Controlling supramolecular motion through chemical design appears to be a powerful tool to increase efficacy for a range of regenerative therapies.”"

-via Good News Network, August 5, 2024

[hemlockesprings]

Hi! If you’re still looking to answer questions I have one that I think about every time I listen to your music.

Your stuff is so unique and imaginative from a creative standpoint, and it always makes me wonder: do you draw inspiration from yourself or from other stories/media that you love? Or a mix of both? Or neither? I’m just really curious about your conceptual process I guess? Especially with how cool your mvs are as well.

Sorry for all the question marks lol, and if that’s too personal I totally get it! I was just curious since I saw so many people sending asks. (Also, I just got my going, going, gone anniversary tshirt and it’s quickly become one of my favorites so thanks for that too! Haha)

hello hello! 👋���

ooooooooooooohhh a nice variety of question marks, I like it! I'm a musician, nothing's TOO personal 😅 (I might regret saying that later)

I say that I draw inspo from everything! Film, TV, other ppl's music, magazines, any type of media!

For example, I just watched this movie called The Love Witch and I lowkey wanna make a album SOLELY based on that film cause it was maaaaaaaaaaaad interesting anywaysssss

I also feel like coming from a biology background, there were so many instances where things would get realllllllllyyyyyy boring studying, reading, etc.) I HAD to find some sort of escape (ie: music) to rejuvenate myself!

But also, I don't actively think too deep on concepts! It's not that I don't care, I just try to write the song the way the song wants to be written! Basically I start kind of talking to myself, and something usually comes up!

If anything, I spend most of my song-making time researching synonyms or rhymes 😭

Same with MVs! Luckily, I get a lot of help in that area, though! (Collaboration is important!)

ty sm for purchasing a shirt! I'm so glad you like it! And thank you for the questions again (NEVER APOLOGIZE FOR THESE TYPES OF THINGS LOL 😂)

-🔒👕🩵

[transmutationisms]

this is probably shaped by my limited frame of reference, but im really fascinated by witnessing the real-time development of adhd as a diagnosis. people attribute so many symptoms to it now or maybe they always did? i was wondering if you have any thoughts on what is the use of adhd specifically as a category within psychiatry. I'm esl so sorry for any confusing wording

no you're right imo; diagnostic categories are always somewhat in flux ofc but ADHD is one that has seen a particularly pronounced shift in the last couple decades. obviously this is multifactorial but my observation goes something along these lines:

'hyperactivity' has been dx'd in children since about the 1950s (also when Ritalin hit the market) but the ADHD dx doesn't really take off until the 90s (also when Adderall, a 2nd-gen reformulation of the 'obesity' drug Obetrol, hit the market). so, it's not all that surprising that 20 years later you see increased patient awareness of the diagnosis, increased popular interest in it, and shifting / expanding ideas of what it means and what ADHD 'is'. it's a relatively young dx.

part of the reason it's young is because it's basically a 'biopsychiatric' dx, meaning it diagnoses certain behaviours as being a 'brain problem' rather than having social causes or context. in practice this is complicated because psychs do use pharmacological approaches in conjunction with psychodynamic ones all the time; nevertheless, the central promise of DSM ADHD and its pharmaceutical treatments has consistently been that the ADHD subject has a physiological, neurological disorder / dysfunction / aberration, and that the drug treatments on the market fix it. that none of this is actually empirically supported is conceptually inconvenient and entrenched by the research process.

the biopsychiatric narrative is worth paying attention to because the context here is one in which it has become commonly accepted that behavioural 'disorders' and affective distress of various kinds can be, basically, either of pure biological origin, or else Your Fault. in the case of childhood hyperactivity, Your Fault historically also included Your Mother's Fault; part of the reason many mothers embraced Ritalin in the 50s and 60s was because the proffered pharmaceutical narrative explicitly challenged the idea that these mothers had done something 'wrong' to result in their (mostly) sons exhibiting disruptive and hyperactive behaviour.

this dichotomy of biology vs personal failing is very overtly present in quite a bit of discourse around ADHD today. if it's my brain being 'wrong' or different, then it's not something I've done wrong but a disease with a simple chemical fix. in this context I don't think it's surprising at all that a lot of popular and patient conceptions of ADHD have seen a considerable widening over the past few decades. often people like to blame this on pharmaceutical companies, and it's true that industry benefits from these discourses and frequently invests in them (eg, via instruments like ADDitude mag). however, that's a pretty simplistic explanation on its own and doesn't really account for the ways in which patients and potential patients also find this diagnostic category personally useful, for reasons ranging from identity-formation to the desire to access prescription amphetamines. ADHD increasingly shows up as a biologised explanation for behaviours ranging from 'eating too many sweets' to 'postural sway' and so on. you can see in such examples how invoking the idea of an aberrant ADHD brain is both reassuring to people who have been made to feel ashamed of certain behaviours, and provides a sense of shared identity and community with others.

all of this is to say: I don't find it surprising at all when I see a relative broadening of notions of ADHD, almost always expressed in biological terms (the 'ADHD brain' operates differently, 'seeks dopamine', causes this or that). ADHD is in some ways a particularly blatant distillation of this general trend in popular psychiatric discourses, for reasons relating to expectations about childhood and child behaviour, and the historical and present relationship between the ADHD label and the regulation of amphetamines. but much of what's happening with ADHD in terms of popular discourses about it can also be seen with many, many other psychiatric diagnoses, to varying extents and in various ways.

my experience writing about ADHD on this website leads me to close by explicitly stating the following: I do not think any ADHD behaviours / symptoms are people's 'fault' or an individual failing; I do not think using drugs for any reason is morally bad or needs to be justified; the fact that I do not think ADHD is a 'brain disease' does not mean I think people are 'making it up' or exaggerating wrt any difficulties they experience personally, professionally, emotionally, &c.

[aut2imagineart]

This is a quick sketch of an alien based on another speculative biology project I started a while back but discontinued.  I'm thinking of returning to said project after I create one more piece related to Proxima B as it's kinda connected to it.

As always, comments and critiques are welcome.