#cell expansion

[botanyone]

Are Giant Tomatoes the Future of Climate-Resilient Crops?

Gigantism, a common domestication trait in many crops, triggers a disproportionate growth in edible parts like stems, leaves or fruits. In a recent study by Mateus Vicente and colleagues, published in Annals of Botany, the researchers at the University of São Paulo in Brazil identified the locus that controls vegetative and reproductive organ size in tomato.  Tomato, scientifically known as…

[whats-in-a-sentence]

Upon binding to IDA, the HAE/HSL2 receptor complex is thought to trigger the MAPK cascade, which leads to the transcriptional activation of genes encoding cell wall loosening enzymes, cell expansion, and cell separation (Figure 22.25).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[tenth-sentence]

These lateral root primordia cells continue cell division and cell expansion until the new lateral root emerges through the cortical and epidermal cell layers (Figure 18.37).

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[bpod-bpod]

Centriole Building

The centriole – an organelle vital for the faithful separation into each daughter cell when a cell divides – is composed of an assembly of proteins. Using expansion microscopy, this study correlates the spatial location of 24 of those proteins with structural features of the human centriole, and then models the molecular architecture of the centriole as it assembles (shown here)

Read the published research article here

Video from work by Marine H. Laporte and colleagues

University of Geneva, Department of Molecular and Cellular Biology, Faculty of Sciences, Geneva, Switzerland

Video originally published with a Creative Commons Attribution 4.0 International (CC BY-NC 4.0)

Published in Cell, April 2024

You can also follow BPoD on Instagram, Twitter and Facebook

[wayti-blog]

"Have you ever thought that light might hold a key to life's mysteries? One hundred years ago, Alexander Gurwitsch dared to propose that living cells emit faint ultraviolet light, invisible to the naked eye, to communicate with and stimulate one another.

It was an idea so ahead of its time that many dismissed it outright. Without a physical theory to back it up, his idea was relegated to the chronicles of history. Yet when I encountered his work, I couldn't help but ask the question: What if the UV effect is quantum mechanical? Armed with modern quantum theory, I began to uncover a new quantum dimension to life itself."

"Faced with this problem, I realized that the ultraviolet radiation he described might be explained using quantum resonance theory. Using resonance concepts from quantum mechanics, I've connected Gurwitsch's observations to a sophisticated framework that explains how faint ultraviolet light can spark significant biological changes.

This explanation, outlined in my new paper published in the Computational and Structural Biotechnology Journal, not only validates his results but also reshapes our understanding of how quantum systems interact with biological environments.

In my research, Gurwitsch's mitogenetic radiation turns out to be a prime candidate for a quantum resonance effect where specific wavelengths of light trigger responses in living cells."

continue reading

[hewkii]

if sanitized octarians don't have vitals are they able to heal from injury? bc healing requires cell division, which requires oxygen, which requires a blood flow, which requires at least one beating heart

although since sanitized ink is made of other organisms maybe they're able to absorb cells out of it rather than creating their own. that would mean they'd need new sanitized ink every time they get hurt. that could become a problem now that there's (presumably) no more being produced 🤔

[wersa]

wait i just realized we finally get valeera and liadrin in the same place this xpac please please please i am on my knees-

[quietwingsinthesky]

even has killed people—though perhaps that depends on your definition of people—and it’s not. how do i put it. it’s never cool, you know? it’s never a moment where this puts them in control of a situation, where they can show off some skill in putting someone down. because even is not, generally, very powerful, and they do not know how to do this.

it just gets messy.

which is one of those terrible reasons why they… well, they don’t like the master, but they have to like that she can do it easy, quick, clean. she can give even the ability to, as well, when she wants. if for no other reason than it means that they won’t have to scrub it raw off their skin later, they appreciate that.

[imunbreakabledude]

every so often i think about how i technically am not hyperfixated on a character who's from a "completed" series even though her time on the series is complete... because, well, we know she's gonna turn up at least for a cameo in season 5! but then i think to myself: haha... DO I know that? do i REALLY know? like yes they said as much after s3, eric kripke did literally say "maeve loves specifically annie" no i mean the pertinent quote was "the series won't end without us seeing maeve again" or whatever and that's a very specific promise. on the other hand, things change all the time! it's already been over 2 years since he said that. and many things could change. with the needs/priorities of the show, or like, dominique mcelligott could be having such a grand time being a doctor (?) or whatever else Not Acting that she has decided to do and perhaps wouldn't want to come back to reprise this role at all, which would be fine of course, but would mean this lil ol' fictional character i am fond of would not appear again, and that would make me feel slightly sad!

OR, something far worse could happen: there could indeed be a maeve appearance in season 5... that contradicts all of my extremely detailed beliefs about the character. so. hm. maybe a part of me hopes dominique is soooooo happy to have left acting behind

[industrynewsupdates]

Cell Expansion Market Insights: A Look at Regional Growth and Opportunities

The global cell expansion market was valued at USD 17.75 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 12.85% from 2023 to 2030. This growth is primarily driven by advancements in automated solutions for cell expansion, the increasing demand for cell therapy products (CTPs), and the development of gene therapies and other biologics. Automation in the cell expansion process plays a crucial role in minimizing manpower and costs, while simultaneously enhancing the reliability and efficiency of production systems, leading to more robust and consistent processes.

As the cell expansion market evolves, technological advancements are not only improving the scalability and cost-effectiveness of production but also helping ensure higher product quality and efficiency. The demand for gene therapies and biologics is growing, especially in the treatment of complex diseases, and this is driving the need for more effective and optimized cell expansion solutions.

For example, in January 2021, Thermo Fisher Scientific introduced the Gibco CTS OpTmizer Pro Serum-Free Media platform, a specialized solution aimed at improving the development and expansion of human T lymphocytes for cell therapy developers working with allogeneic workflows. This platform is specifically designed to target donor cell metabolism, making it ideal for developing off-the-shelf, allogeneic cell therapies. By eliminating the need for serum and providing a more controlled environment for cell growth, this serum-free media platform offers a more cost-effective, scalable, and reliable solution for cell therapy manufacturing.

This product is a significant advancement in addressing the manufacturing challenges faced by developers of allogeneic therapies, where donor variability and the need for scalable production are key concerns. The introduction of such innovations by industry leaders helps to ensure that companies are better equipped to meet the increasing demand for cell-based therapies and biologics globally.

Gather more insights about the market drivers, restrains and growth of the Cell Expansion Market

Regional Insights

North America

In 2022, North America accounted for the largest revenue share of 39.0% in the global cell expansion market. The region is expected to maintain its leading position over the forecast period due to a combination of factors, including increased funding from both government agencies and private organizations. These funding initiatives are critical in accelerating the manufacturing of stem cells and the development of regenerative medicines and cellular therapy products, which are driving the demand for cell expansion platforms in North America.

The investment in regenerative medicine and cell therapies in the region is expected to continue to grow, as the need for more effective treatments for conditions such as cancer, neurological disorders, and cardiovascular diseases increases. In addition, the presence of key players in the biotechnology and pharmaceutical industries, along with a well-established healthcare infrastructure, further bolsters North America's dominance in the market. The ongoing focus on stem cell research and biologics development will continue to fuel the demand for advanced cell expansion technologies in the coming years.

Asia Pacific

The Asia Pacific region is projected to experience the fastest compound annual growth rate (CAGR) of over 15.0% during the forecast period. This rapid growth can be attributed to the increasing efforts of local pharmaceutical and biotechnology companies in the region to develop and commercialize their cellular therapies. As the biopharmaceutical sector in countries like India, China, and Japan expands, the need for advanced cell expansion technologies to support the production of cell therapies is becoming more pronounced.

A key example of the region’s growing focus on cellular therapies is the collaboration between Alkem Laboratories and Stempeutics in September 2022, which led to the launch of “StemOne”, the first off-the-shelf cell therapy product for treating knee osteoarthritis in India. The product received regulatory approval from the Drugs Controller General of India (DCGI), marking the first approval of an allogeneic cell therapy product for commercial use in the country. This significant development reflects the growing investment in regenerative medicine and cell therapy in India and is expected to further drive the demand for cell expansion platforms in the region.

The Asia Pacific market is also supported by factors such as increasing healthcare spending, advances in biotechnology, and the growing prevalence of chronic diseases. As companies in this region continue to make strides in developing new cell therapies and biologics, the need for advanced cell expansion solutions will continue to grow.

Browse through Grand View Research's Medical Devices Industry Research Reports.

• The global biologics market size was valued at USD 461.74 billion in 2022 and is expected to grow at a compound annual growth rate (CAGR) of 10.3% from 2023 to 2030. 

• The global cell therapy market size was estimated at USD 4.74 billion in 2023 and is expected to grow at a compound annual growth rate (CAGR) of 22.66% from 2024 to 2030.

Key Companies & Market Share Insights

The cell expansion market is highly competitive, with several key players focusing on expanding their market presence through a variety of strategies, including collaborations, partnerships, product development, and expansion into untapped regions. To maintain a competitive edge, these companies are increasingly leveraging cutting-edge technologies and innovative solutions to meet the growing demand for cell-based therapies.

Strategic Collaborations and Developments

1. STEMCELL Technologies and Applied Cells Inc. entered into a partnership in April 2022 to create an innovative solution for cell separation. The collaboration combined STEMCELL’s EasySep kits with Applied Cells’ MARS platform to enhance the ease and automation of isolating cells from different biological samples, such as whole blood, bone marrow, apheresis products, and tissues. This advancement will improve the efficiency and effectiveness of cell isolation for both research and medical purposes, significantly enhancing the overall cell expansion process.

2. In May 2023, panCELLa and BioCentriq signed a research agreement to explore stem cell-derived Natural Killer (NK) cell expansion technology. The collaboration aims to evaluate panCELLa’s genetically engineered feeder cells, which are designed to enhance the expansion rate, total yield, and potency of NK cells. NK cells have gained attention for their role in immunotherapy, particularly in treating cancers, and the collaboration is expected to improve the efficiency of NK cell production, facilitating the development of new therapies.

Key Companies in the Cell Expansion Market

The global cell expansion market is driven by a number of leading companies that specialize in providing innovative products and solutions to support the production of cell therapy products. Some of the prominent players in the market include:

• Thermo Fisher Scientific, Inc.

• Corning Incorporated

• Merck KGaA

• Miltenyi Biotec

• BD (Becton, Dickinson and Company)

• Terumo BCT, Inc.

• Sartorius AG

• Takara Bio Inc.

• TRINOVA BIOCHEM GmbH

• upcyte technologies GmbH

Order a free sample PDF of the Cell Expansion Market Intelligence Study, published by Grand View Research.

[luckydige45]

The global cell expansion market is valued at USD 18.75 Billion in 2023 and is projected to reach a value of USD 60.08 Billion by 2033 at a CAGR (Compound Annual Growth Rate) of 12.35% between 2024 and 2033.

[researchinsights]

The globalcell expansion market is projected to reach USD 16.8 billion in 2023, registering at a Compound Annual Growth Rate (CAGR) of 15.1% during the forecast period 2024-2030. The growth of the marketis majorly driven by the increasing focus on r&d for cell-based therapies

[bpod-bpod]

Blown-up in Blood

An atlas of development of the malaria parasite as it proliferates in its blood cell stage generated using expansion microscopy – a means of physically inflating tissue to enhance the microscopic view

Read the published research article here

Image from work by Benjamin Liffner and Ana Karla Cepeda Diaz, and colleagues

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, December 2023

You can also follow BPoD on Instagram, Twitter and Facebook

[mitalipingale]

The Cell Expansion Market in 2023 is US$ 22.85 billion, and is expected to reach US$ 71.47 billion by 2031 at a CAGR of 15.30%.

[ole-to-you-nonetheless]

My dissertation (which is due tomorrow afternoon) needs to be 5,000 words (well written and coherent, not just any words) and it’s a subject I care about and picked myself (Arthurian Art in Wales) which makes it frustratingly MORE difficult to write about (I don’t want to fuck it up or be factually wrong about anything), and I’m currently very behind on the word count (just over 3,200 words, with 18 hours to go) and I’ve been CONSISTENTLY working on it (I did not leave it to the last minute) for months and yet. And Yet. The ONLY thing occupying my mind is not, say, academic success, but which Merlin characters fit with which The Amazing Devil songs. I am going to combust

[robo-writing]

So that idea you had with 70s Logan being selfish while eating you out... could we get an expansion?

*cracks knuckles* let’s get into it

Logan loves pussy, short and sweet. His problem is that he loves it a little too much.

It makes for a great time with whatever lucky lady he’s got in his bed (or the couch. Or the kitchen.) but it also means that it’s going to be quite a while before he tires himself, if that even happens. Where his younger self differs is that he’s firmly rooted in his “I don’t need meaningful relationships” attitude so if he’s bringing someone to bed, it’s for one thing and one thing only.

He’s got an urge to satisfy, and you just so happened to be the nearest thing around.

That isn’t to say he’s a total asshole; he tells you up front not to expect anything more than what he’s offering, and if you don’t take his advice? That’s all on you. His deal is a simple one, take it or leave it.

Now, assuming you accept, you’ll be happy to know that he can talk the talk and walk the walk—that is to say, he’ll have your legs shaking within the first five minutes guaranteed. Something about his enthusiasm is half the show, the other half is how adamant he is about keeping his lips glued to your pussy.

Over and over again you cum—your weeping cunt crying out against his fingers, his smug grin as you beg him for a break—only to be met with the sounds of his tongue flicking at your clit. Your hands tug at his hair, begging him to stop, trying your damndest to wiggle free from his iron hold but he doesn’t budge in the slightest. If anything at all your movement just annoys him further, and in turn, makes him take out his anger on your sensitive cunt.

“Stop fucking movin’” he muffles against your sex, but it’s easier said than done. Even when you slap against his arms he doesn’t flinch, instead opting to glare at you from below while his fingers scissor you open.

“Stop being fuckin’ difficult—“ he starts, growling out when tears start streaming down your face. It’s immediately met with a slap to your puffy cunt, the shock of it sending you reeling forward.“Don’t whine, you asked for this.”

You want to argue, tell him you asked for a one night stand and not a torture session—unfortunately for you, your brain cells leak from your ears every time his beard scratches between your thighs.

And then, somewhere between the long-drawn out agony of your nerves being lit on fire is the smallest ember of pleasure. An echo, and then a roar, a spark that turns into a roaring fire and then something just clicks.

All of a sudden you’re going from stop, Logan, I can’t to yes, more, please between what little semblance of sanity you can muster.

The sudden change in attitude makes him grin. “Told you you’d enjoy yourself.”