#arterial pressure

[er-cryptid]

Ventricular Ejection

-- follows isovolumetric ventricular contraction

-- both ventricles continue to contract

-- the ventricular pressures exceed aortic and pulmonary arterial pressure

-- the aortic valve and pulmonary valve open

-- blood is ejected into aorta and pulmonary artery

[leaderincrows]

I don’t need Jesus, I need a 6’2” crime lord sub that wants me to chew on him

[literallymechanical]

Hello, I read Exordia and the Baru Cormorant series because of you. I would like financial compensation as I now have Many Thoughts and am sad. Just kidding they're great and everyone should go read them. Exordia did make me cry a lot though.

I went to one of Seth Dickinson's book signings, and in the q&a somebody asked him who would win: the Hive from Destiny or Exordia from Exordia. Instead of answering, he just gave a lengthy, gruesome explanation of the Byford Dolphin diving bell explosive decompression accident and then moved on to the next question.

[nemfrog]

American national Red cross text-book on first aid. 1908. Carotid artery pressure to stop head bleeding.

Internet Archive

[eldritch-bisexual]

God, Li Lun takes blow after blow. People go and poke him right in the trauma (Zhu Yan is the worst at it and most of the time he doesn't even notice!)

I think he's excused. My first 2025 take is that Li Lun deserved to commit all the crimes. If I was him I would have done worse.

(His chat with Wen Xiao was eye opening too. "Who should be suffering is not me, or you. It's him." Boy just wanted to warn the next girl!)

[wombywoo]

youre too good to us, giving us delicious art for free!!!

Curious though, who's blood is that in the art?

asdfghjk I'm really just out here drawing stuff for me, but I'm happy to share it with you all 🥰

(it's Quinnie's blood btw 💁‍♀️)

[catkin-morgs-kookaburralover]

the internet: yeah to practise harm reduction you go for areas that have more flesh to avoid going too deep and needing medical attention

me, an idiot: let's pick this spot anyway, how bad can it be. ...how did i get that deep that quickly

[brandnewcouch]

tonight’s thought: sinus pressure so strong that it’s pulsating, it practically has its own heartbeat

[skyloftian-nutcase]

I'm sorry, I just... had to give y'all a glimpse of what it's actually like

*in medical dramas*

Doctor who never seems to leave patient's general vicinity: His blood pressure's dropping, he's crashing!! *intense music and people rushing around and alarms blaring with fancy disco lights flashing*

*in real life*

Me, minding my own business, hearing an alarm beep to indicate hypotension: *grumbling as I get up for the fifth time to go back into the room and adjust blood pressure IV medication* Gosh darn it Steve stop misbehaving, this is just downright rude.

[fantastic-mr-corvid]

WIP Friday!

bc i didnt do a writing one this week and restarting chapter three of rage with a new direction has cleared my writers block and im back on a roll >:3

snippet under the read more for descriptions of blood & major injuries. Why did i ever think i should pass over writing Conficcare holding Celias face in his hands as he tried to stem the blood flow...

Conficcare rushes towards Celia, taking the clean cotton vest for Celia to change into and shoving it over her face, pressing his thumbs above her ears and his fingers on her jaw to cut off blood flow to the weeping arteries, his palms over her cheeks and brows to put pressure on the bleeding wounds, a prayer on his tongue that the rhythmic wet pulsing of blood against his hands would stop before Celia's heart did.

The vest darkens under his fingers, blood soaked through the first layer of fabric, as the noise of the chaos behind him grates on his ears.

He presses even harder, fingers and thumbs feeling for the arteries, breathing a sigh of relief when the pulsing against his fingers started weakening before yelling for Marco to get more clean cloth. The pulsing gets even weaker, and he pushes even harder, fingers pressing against bone, shaking under the pressure he's exerting.

The damp red finally soaks through the second layer of cotton, and he screams for Marco to hurry the fuck up-

[biology-geology-beaches-india]

TSRNOSS, p436.

[etapereine]

.

[kakashihasibs]

I am so glad emergency vets are a thing

[jcmarchi]

New method enables fast, accurate estimates of cardiovascular state to inform blood pressure management

New Post has been published on https://thedigitalinsider.com/new-method-enables-fast-accurate-estimates-of-cardiovascular-state-to-inform-blood-pressure-management/

New method enables fast, accurate estimates of cardiovascular state to inform blood pressure management

If patients receiving intensive care or undergoing major surgery develop excessively high or low blood pressures, they could suffer severe organ dysfunction. It’s not enough for their care team to know that pressure is abnormal. To choose the correct drug to treat the problem, doctors must know why blood pressure has changed. A new MIT study presents the mathematical framework needed to derive that crucial information accurately and in real time.

The mathematical approach, described in a recent open-access study in IEEE Transactions on Biomedical Engineering, produces proportional estimates of the two critical factors underlying blood pressure changes: the heart’s rate of blood output (cardiac output) and the arterial system’s resistance to that blood flow (systemic vascular resistance). By applying the new method to previously collected data from animal models, the researchers show that their estimates, derived from minimally invasive measures of peripheral arterial blood pressure, accurately matched estimates using additional information from an invasive flow probe placed on the aorta. Moreover, the estimates accurately tracked the changes induced in the animals by the various drugs physicians use to correct aberrant blood pressure.

“Estimates of resistance and cardiac output from our approach provide information that can readily be used to guide hemodynamic management decisions in real time,” the study authors wrote.

With further testing leading to regulatory approval, the authors say, the method would be applicable during heart surgeries, liver transplants, intensive care unit treatment, and many other procedures affecting cardiovascular function or blood volume.

“Any patient who is having cardiac surgery could need this,” says study senior author Emery N. Brown, the Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience in The Picower Institute for Learning and Memory, the Institute for Medical Engineering and Science, and the Department of Brain and Cognitive Sciences at MIT. Brown is also an anesthesiologist at Massachusetts General Hospital and a professor of anesthesiology at Harvard Medical School. “So might any patient undergoing a more normal surgery but who might have a compromised cardiovascular system, such as ischemic heart disease. You can’t have the blood pressure being all over the place.”

The study’s lead author is electrical engineering and computer science (EECS) graduate student Taylor Baum, who is co-supervised by Brown and Munther Dahleh, the William A. Coolidge Professor in EECS.

Algorithmic advance

The idea that cardiac output and systemic resistance are the two key components of blood pressure comes from the two-element Windkessel model. The new study is not the first to use the model to estimate these components from blood pressure measurements, but previous attempts ran into a trade-off between quick estimate updates and the accuracy of estimates; methods would either provide more erroneous estimates at every beat or more reliable estimates that are updated at minute time scales. Led by Baum, the MIT team overcame the trade-off with a new approach of applying statistical and signal processing techniques such as “state-space” modeling.

“Our estimates, updated at every beat, are not just informed by the current beat; but they incorporate where things were in previous beats as well,” Baum says. “It’s that combination of past history and current observations that produces a more reliable estimate while still at a beat-by-beat time scale.”

Notably, the resulting estimates of cardiac output and systemic resistance are “proportional,” meaning that they are each inextricably linked in the math with another co-factor, rather than estimated on their own. But application of the new method to data collected in an older study from six animals showed that the proportional estimates from recordings using minimally invasive catheters provide comparable information for cardiovascular system management.

One key finding was that the proportional estimates made based on arterial blood pressure readings from catheters inserted in various locations away from the heart (e.g., the leg or the arm) mirrored estimates derived from more invasive catheters placed within the aorta. The significance of the finding is that a system using the new estimation method could in some cases rely on a minimally invasive catheter in various peripheral arteries, thereby avoiding the need for a riskier placement of a central artery catheter or a pulmonary artery catheter directly in the heart, the clinical gold standard for cardiovascular state estimation.

Another key finding was that when the animals received each of five drugs that doctors use to regulate either systemic vascular resistance or cardiac output, the proportional estimates tracked the resulting changes properly. The finding therefore suggests that the proportional estimates of each factor are accurately reflecting their physiological changes.

Toward the clinic

With these encouraging results, Baum and Brown say, the current method can be readily implemented in clinical settings to inform perioperative care teams about underlying causes of critical blood pressure changes. They are actively pursuing regulatory approval of use of this method in a clinical device.

Additionally, the researchers are pursuing more animal studies to validate an advanced blood pressure management approach that uses this method. They have developed a closed-loop system, informed by this estimation framework, to precisely regulate blood pressure in an animal model. Upon completion of the animal studies, they will apply for regulatory clearance to test the system in humans.

In addition to Baum, Dahleh and Brown, the paper’s other authors are Elie Adam, Christian Guay, Gabriel Schamberg, Mohammadreza Kazemi, and Thomas Heldt.

The National Science Foundation, the National Institutes of Health, a Mathworks Fellowship, The Picower Institute for Learning and Memory, and The JPB Foundation supported the study.

[realkaijuhavecurves]

Gently directing all those writing blood drinking scenes where the vampire drinks from an artery to the scene in What We Do In the Shadows where Viago accidentally bites into an artery instead of a vein on his victim...

[thebibliosphere]

In the never-ending quest to alleviate my migraines, I bought a special angled pillow that lets you sleep on your side while your arm just kind of hangs through a whole in the middle. I did this because I’m a left-sided sleeper, always have been.

Until my neck subluxated and now I can’t sleep on that side without compressing some vital nerves and blood arteries. I also can’t sleep on my back right now because the pressure compresses my occipital nerve. Basically sleeping has been a nightmare recently, but that’s not the point of this post.

The point was I brought this up in physical therapy to talk about how great this pillow is because I can now sleep on my right side without the stupid thing going numb or waking me up because it hurts. And my PT was like wow, great! How did you sleep on your left side for so long without it being an issue?

And I said, oh that’s easy. I just tuck that shoulder out of the way.

And she said, ...what?

And I said, yeah, I just tuck it out the way. Not like my right shoulder. That one doesn’t move as well. It just hurts, I think there’s something wrong with it.

And my physical therapist asked me to demonstrate what I mean when I say I ‘tuck my shoulder out of the way,’ and haha, you’re never going to believe this, turns out I’ve just been casually pulling my left shoulder out of the socket for, oh, let’s see, 30 years? And then napping on it like hmmnm yess comfy.

Anyway. I looked up from my demonstration and my physical therapist was making this face: