#and not about... the healthcare

[colorisbyshe]

I do think it's interesting (yet extremely predictable) that the meme-ification of and conspiratorial thinking around Luigi has 100% smothered the embers of intentional movement. If you spend all of your time talking about how he didn't do it, someone else did, he's totally been framed you end up spending no time on actually talking about... what to do next?

A movement where no one actually did anything and nothing actually happens will always be a movement where no one does anything and nothing actually happens.

But it was always obvious it was going to go this way and it's gonna keep going this way because people are more interested in seeming smart and seeing the truth and jokes where no one else sees them than they are in like... figuring out what to do next

And I'm not above that, I don't know what to do next besides things so abstract they're meaningless but like... if there was a communal interest in doing this, it'd be much easier to figure this shit out together instead of just all of us, separately, spewing things so abstract they're meaningless

But tbh this post is a week late, everyone has moved on because no one has the attention span for a movement anyways

[bluesky-out-of-context]

[reasonsforhope]

A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

[incognitopolls]

This is asking about any significantly life altering or life threatening physical disease, infection, or accident that a medical specialist would have needed to test/treat you for.

Anon had a cancer scare that thankfully turned out to be benign, but some bad info and a long waitlist made for a very stressful time. They're wondering how many others have been there!

–

We ask your questions so you don’t have to! Submit your questions to have them posted anonymously as polls.

[gmaybe666]

free luigi the new italian american folk hero

[wilwheaton]

[irlcupcake]

10 of my favorite easy glow up tips! 𐙚 ‧₊˚ ⋅

get a gua sha!! not expensive at all and made such a difference in my face shape and carving out my cheek bones and jawline. there’s lots of good tutorials on tiktok or youtube!

tea in the morning/night! there’s so many teas to help with different things but my favorite’s are spearmint tea for clearing skin and green tea for reducing bloating.

ice your face! helps SO much with de-puffing and closing up your pores! dipping your face in a bowl with ice water can reduce inflammation, help with acne and reduce oily skin!

make sure to get enough sleep! It’s so easy to stay up scrolling on tumblr until the sun comes up but getting enough sleep is so important mentally and physically!

find a skincare routine that works for you and remember too much skincare can be bad for your skin! my skin was breaking out the worst when i was using a bunch of skincare and It’s cleared so much since i simplified my routine.

use a lash/brow serum! my favorite brand is grande lash and it’s a little pricey but using castor oil works as well and it’s super affordable.

going on walks! I’ve never been a fan of intense exercises and I’m a chronic bed rotter but putting on my favorite hot girl playlist and strutting on the treadmill/sidewalk is genuinely so fun!

rosemary oil for hair growth! my holy grail of hair growth products along with a scalp massager. my whole life my hair grew so slow and since using rosemary oil i have to trim my bangs twice a month sometimes!

i cannot stress this one enough..wear what YOU want! don’t let new trends or judgment from others stop you from embracing your true style. we look our best when we feel most confident!

most importantly ~ take care of yourself! make sure you’re eating enough, drinking water, listening to your body and being gentle with yourself always. improving ourselves can be so fun but make sure it’s not at the expense of your mental health <3

[haberdashing]

Musings on the "depose" part of "deny, defend, depose":

When I first read those words, my mind, like most people's I think, read "depose" in the sense of "overthrow". Like how you'd depose a king, kicking him out of his position of authority, in a way that may or may not involve him losing his life as well as his power over others.

But when I mentioned it to a friend, that friend brought up that the word has a second meaning that might be relevant here as well.

In the legal field, "depose" is the verb form of "deposition". Deposition itself is one of the ways you can go about getting evidence from somebody. A deposition is when you get someone to swear that they're telling the truth, and you ask them questions, or ask them for explanations, and they have to answer truthfully. Documents might be part of a deposition, but it's not about the documents themselves, exactly; it's about what they mean, the essential truth behind what the documents describe.

(In my line of work, this might be something like, "Does that income amount listed on your court filing include this bonus listed in your bank statements?" but with a lot of questions leading up to that one to establish things like the bonus being from their employer and deposited into their bank account.)

In a way, it's like the cross-examination part of a trial isolated. (Assuming that it's the other side being deposed; it could also be a witness or third party, but almost by definition you only do depositions on a party that isn't your own client in the case.) One side asks the hard questions, and unless those questions break rules, the other side has to answer them. And like cross-examination, if someone's not truthful in a deposition, that can cause them to face all sorts of sanctions for perjury.

Now, it's very probable that the assassin in this case meant the word only in the more commonplace sense of the word, comparing the CEO to a ruler that needs to be removed from power. But when you consider the legal definition of the word, it seems almost like an ultimatum:

Tell the truth about your unjust business practices, or else lose your power to enact them.

Be deposed, or else be deposed.

[faerygardenparty]

Idk it just annoys me as someone who was heavily affected by a mass shooting and had to suffer through a media parade of “he was just a poor bullied mentally ill kid who sat alone at lunch 😢” nonstop right after not knowing if I’ll ever see my friends again, only for THIS to be the fucking case where all of a sudden everyone grows a conscious and decides we’re not allowed to sympathize with the killer, like fuck right off, I spent the latter half of high school wondering if I was going to be next, there are still days where I can barely stand to be out in public places, I don’t actually give a shit that billionaire CEOs with their private security teams are crying about how scary it is and they don’t know if they’re going to be next and how we should all feel so so bad for them, that same sympathy was never extended to me or my loved ones so why should I give it to them?

[rowsandrowsofnothing]

I just want to share why I absolutely do not give a fuck that Brian Thompson had a family. It’s simple.

I have one too.

Me, who:

Was born needing heart surgery, and if a team of six surgeons hadn’t argued for me while I was in the womb, I would’ve died at birth from internal bleeding. My parents would have had to watch their baby choke to death on his own blood.

Grew to suffer severe chronic pain through joint damage that I am unable to receive treatment for, and must go through with literally not even medication. The only mobility aid I have is a cane my father was unable to use anymore.

Was born with spinal deformity that developed into scoliosis. That I just have to live with because insurance says it isn’t severe enough for surgery, despite my hips being noticeably displaced to the point my legs are different lengths.

Needs allergy shots to be able to go outside without risking anaphylaxis. My family spent almost four years chasing them because insurance said I had to fail EVERY other drug and treatment on the market before I could have the shots. We were bounced from doctor to doctor, hospital to hospital, begging for treatments that we knew would fail. My parents spent thousands on failed treatments in a desperate attempt to get me ANY relief from the pain I went through daily.

Is incredibly lucky, because despite all the shit my family went through, I lived. We had just enough money to spare on trying to get me treatment.

I am lucky because I lived.

Millions of others did not.

My extended family has lost people because of health care denials. Too many everyday people have died for money in these people’s pockets.

Brian Thompson and scum like him are directly responsible for the deaths and suffering of millions of Americans. His money was made with blood, and he paid for it in blood.

Deny. Defend. Depose.

[can-we-be-kind]

I genuinely wonder if this is going to start something

Will more people start killing CEOs?

Are there more people willing to potentially give up their freedom for the ‘greater good’?

How many people are in the position to actually access a weapon and be within proximity to a billionaire?

Will there actually be a revolution?

Are people too scared to actually start something?

Are the people who want to, too young, too weak, too ill, ect. to actually be able to do something?

Are you able to actively do something?

Are you able to go outside right now and kill a CEO?

Are the charities working? Are the protests working? Are the movements working?

Is it really getting better?

Maybe if you don’t like something, you should do something.

I dunno man, maybe 1700s France was onto something

[arch-aeology]

Merry Christmas! Here’s a Jayvik au where they’re college students in 80s New York

[erinwantstowrite]

i am absolutely baffled by the amount of people who keep calling the CEO killer "just like Batman" because I thought it was common fucking knowledge that that man does not use guns??? and does not kill???? before I even got into Batman that was very much something that I knew. just because he is a vigilante does not mean that he's like Batman. I've even seen people call him the Joker???? what planet are you fucking living on??? if you want to compare him to a Batman character look at literally half of his kids when they're having a bad day. I'm more inclined to believe that this is something Jason Todd would do, if he somehow was like "I need to be discreet about it" for the first time in his life. honestly I can see Tim doing it. I know they keep saying that Tim did not kill anybody when he blew up all of the League bases... but let's be real for two seconds. Tim Drake has an alternate future where he becomes Gun Batman. he knows how to create multiple fake identities for himself and rarely gets caught. in a timeline where he wasn't losing his shit and was planning out a murder meticulously for a reason and a message it'd be like this. Jason and Tim both have the dramatics to put the Monopoly money in a backpack. Actually they'd consider this a bonding exercise and do it together

[incognitopolls]

*Not counting routine checkups or normal doctor's visits– this is asking about serious illness, injury, etc where you were in a bed.

–

We ask your questions so you don’t have to! Submit your questions to have them posted anonymously as polls.

[hollow-keys]

THEE funniest thing about the Luigi Mangione case is establishment pundits trying to misapply class rhetoric to defend the healthcare executive like "Luigi Mangione came from a rich family, Brian Thompson worked his way up from middle class America" like broooo no way are you trying to weaponise misapplied idpol to gloss over real proletarian and bourgeoise dynamics and frame a fucking healthcare executive as more disadvantaged brooo you're only proving how out of touch you are with the material realities of class if you think any of this changes the material power Brian Thompson had and wielded over millions of people for a profit brooo you're trying to bring Clintonian idpol to a class warfare fight and you are going to lose SKSKEKAJDJ

[doomdoomofdoom]

you know what, maybe living through historical events isnt so bad if they're fun ones