#Coronavirus disease COVID-19

[tomorrowusa]

People need to be reminded of Trump's woeful incompetence which came to a head during the pandemic emergency and resulted in the unnecessary deaths of hundreds of thousands of Americans.

The Obama administration successfully dealt with the threats from swine flu and Ebola. There was no swine flu disaster, there was no Ebola disaster, and there was even no Zika disaster because competent people were running the US. Near the end of Obama's term, his National Security Council staff put together a 69-page playbook on how to deal with pandemic emergencies. It's called "Playbook for Early Response to High-Consequence Emerging Infectious Disease Threats and Biological Incidents". Of course Trump ignored the document and plunged the nation into COVID hell.

Trump team failed to follow NSC’s pandemic playbook

Michelle Obama, in one of her best speeches ever in Kalamazoo this weekend, excoriated Trump's incompetence.

Michelle Obama laced into Donald Trump in a searing speech in Michigan on Saturday, accusing the former president of “gross incompetence” and having an “amoral character” while challenging hesitant Americans to choose Kamala Harris for US president. “By every measure, she has demonstrated that she’s ready,” the former first lady told a rapt audience in Kalamazoo. “The real question is, as a country, are we ready for this moment?” [ ... ] In raw and strikingly personal terms, she asked why Harris was being held to a “higher standard” than her opponent. Trump’s handling of the Covid-19 pandemic and his failed attempt to cling to power after losing the 2020 election should alone be disqualifying, Obama argued. But now the people who worked closest with him when he was president – his former advisers and cabinet secretaries – had stepped forward with a warning that he should not be allowed to return to power.

ICYMI, here is Michelle Obama's speech in Michigan.

Too many people have been afflicted by Trumpnesia. They seem to have forgotten the catastrophe that happened starting on 22 January 2020 when the first COVID infection was discovered on US soil. On that day Trump told CNBC: "we have it totally under control" and "it's going to be just fine".

Instead of following Playbook for Early Response to High-Consequence Emerging Infectious Disease Threats and Biological Incidents, Trump did the usual bullshit Trump things like criticize the Oscars and rage-tweet from the bathroom. He belatedly declared a state of emergency on Friday the 13th of March – the day after the stock market crashed.

Don't let anybody in real life get away with describing the Trump years as some sort of utopia.

Some people disingenuously claim they don't know enough about Kamala Harris despite her 20 years in public service. We all know more than enough about Trump's egregious ineptitude which turned a national emergency into a prolonged national nightmare.

[gumjrop]

Make your voice heard and ask the CDC to:

Recommend COVID vaccines for all ages and health statuses at least twice a year (spring vaccine access for all) AND

Support more frequent updates to the vaccines, adjusted for the latest variants.

Submit a public comment using our sample language below.

The committee is anticipated to vote on the following topic on day 1 of the meeting (October 23): “Use of additional doses of COVID-19 vaccine in immunocompromised individuals and older adults following an initial dose of 2024–2025 vaccine”

Your comments make a difference. At this committee’s June 2024 meeting, public comments from our community led to the committee’s decision to make fall COVID vaccines available to people of all ages, rather than limiting eligibility to specific risk groups. Please join us in making your voice heard for spring COVID vaccine access for all, and at least twice a year access going forward.

Submit Written Comment

You can also register to give Oral Public Comment at the upcoming online CDC ACIP Meeting October 23-24 at: https://www2.cdc.gov/vaccines/acip/acip_publiccomment.asp 

Submit written comments and/or register to make oral comments at the meeting by Friday October 18 at 11:59pm Eastern Standard Time.

It’s important to submit a personalized comment, which can be brief. Ideas for a personalized comment:

How you, your family, or your community would be impacted by spring vaccine eligibility being restricted to only high risk groups (such as older age or immunocompromised status)

Barriers to vaccination your have faced, particularly if your eligibility was questioned or misinterpreted by a vaccine provider

How out-of-pocket costs are a barrier to getting the latest vaccines

Also feel free to take inspiration from or borrow the language in our sample public comment below.

Step-By-Step Submission Instructions:

Step 1. Go to the Regulations.gov to submit your comment.

Step 2. Type in your comment under the field, “Comment.”

Step 3 (optional). Submit a PDF or Word version of your comment under, “Attach Files.”

Step 4. Select either “Individual” or “Anonymous” depending on if you want to share your personal identifiable information that will be publicly available on the Federal Register.

Step 5. If selecting “Individual,” minimally provide your first and last name. If selecting “Anonymous” you can directly submit the comment without sharing your personal identifiable information. Click “Submit Comment.”

Example Comment:

Docket No. CDC-2024-0072-0001 COVID vaccination at least twice a year (at least every six months) must be recommended for people of all ages, regardless of health status. A restrictive approach to eligibility creates undue barriers for vulnerable people and discourages high risk people from getting needed vaccine boosters. People of all ages, including those who are aged 65 and older or immunocompromised, should have the opportunity to receive another COVID vaccine in the spring of 2025. The vaccine schedule should address waning efficacy in the months following vaccination [1-3] as well as emergence of new SARS-CoV-2 strains by recommending updated vaccination for all ages, at least every six months. Waning efficacy is seen with all COVID vaccine types, and recent research into the biological mechanisms of waning [4] supports that this effect occurs regardless of age or immunocompromised status. Recent vaccination is associated with a lower risk of developing Long COVID following a COVID infection [5] as well as a lower risk of Multisystem Inflammatory Syndrome in children (MIS-C) [6].  The CDC’s clear and unequivocal recommendation of COVID vaccination at least twice a year for all ages will influence recommendations by healthcare providers, and coverage by health insurance. Moreover, it will improve public awareness in people of all ages about the importance of recent vaccination (within the last six months) to provide the best protection as part of a multilayered approach to preventing illness. The CDC must ensure equitable and affordable access to updated vaccines and prevent limited access because of financial constraints or demographics. The CDC’s Bridge vaccine access program ended in August 2024 [7], leaving many uninsured and underinsured adults without COVID vaccine access. We ask you to advocate for free COVID vaccine access for all of us to reduce barriers and hesitation to vaccination. References: 1. Link-Gelles R. Effectiveness of COVID-19 (2023-2024 Formula) vaccines. Presented at: FDA VRBPAC Meeting; June 5, 2024. Accessed June 12, 2024. https://www.fda.gov/media/179140/download 2. Wu N, Joyal-Desmarais K, Vieira AM, et al. COVID-19 boosters versus primary series: update to a living review. The Lancet Respiratory Medicine. 2023;11(10):e87-e88. doi:10.1016/S2213-2600(23)00265-5 3. Menegale F, Manica M, Zardini A, et al. Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity: A Systematic Review and Meta-analysis. JAMA Netw Open. 2023;6(5):e2310650. doi:10.1001/jamanetworkopen.2023.10650 4. Nguyen DC, Hentenaar IT, Morrison-Porter A, et al. SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination. Nat Med. Published online September 27, 2024:1-10. doi:10.1038/s41591-024-03278-y 5. Fang Z, Ahrnsbrak R, Rekito A. Evidence Mounts That About 7% of US Adults Have Had Long COVID. JAMA. Published online June 7, 2024. doi:10.1001/jama.2024.11370 6.  Yousaf AR. Notes from the Field: Surveillance for Multisystem Inflammatory Syndrome in Children — United States, 2023. MMWR Morb Mortal Wkly Rep. 2024;73. doi:10.15585/mmwr.mm7310a2 7. https://www.cdc.gov/vaccines/programs/bridge/index.html 

Full instructions for written and oral comment and meeting information can be found at: https://www.cdc.gov/acip/meetings/

You can also register to give Oral Public Comment at the upcoming online CDC ACIP Meeting October 23-24 at: https://www2.cdc.gov/vaccines/acip/acip_publiccomment.asp 

You must register by October 18 at 11:59pm Eastern Standard Time

CDC’s ACIP meeting information on the Federal Register: https://www.federalregister.gov/documents/2024/09/30/2024-22357/meeting-of-the-advisory-committee-on-immunization-practices 

Full Statement:

Vaccination with the latest updated vaccines continues to be foundational to a multilayered approach to COVID, providing protection against both acute disease and Long COVID. Far too few Americans have received the latest vaccines. As of October 11, 2024, only 11.2% of all adults and 26.7% of adults aged 65 and older had received an updated 2024-2025 COVID vaccine. Data for children were unavailable at the time of this writing (October 15, 2024). COVID vaccination rates continue to lag behind influenza vaccination rates. As of July 27, 2024, only 9% of adults aged 65 and older received the recommended two doses of last year’s 2023-2024 vaccine.

Vaccine efficacy wanes significantly four to six months following vaccination, making updated vaccination important for all people as COVID continues to spread in our communities. Vaccine approaches that restrict access based on age or risk status put all of us at risk and leave those at high risk of severe consequences of COVID infection confused about whether they qualify to receive additional doses. These high risk patients may also face barriers as vaccine providers misunderstand the guidelines. A more frequent vaccination approach providing vaccination at least every six months as well as frequent updates to match current variants is needed to better protect all of us amid year-round COVID spread.

Recent vaccination is associated with a lower risk of developing Long COVID following a COVID infection as well as a lower risk of Multisystem Inflammatory Syndrome in children (MIS-C). Waning efficacy is seen with all COVID vaccine types, and recent research into the biological mechanisms of waning supports that this effect occurs regardless of age or immunocompromised status. 

The CDC’s Bridge Access Program, which previously provided COVID vaccines to uninsured and underinsured adults free of charge, ended in August 2024. The end of this program without replacement coverage puts people at risk, and public health officials must advocate for free vaccine access for all of us, including those who are uninsured and underinsured.

Submitted written comments or registration to make oral comments at the meeting must be received by the CDC no later than October 18 at 11:59pm Eastern Standard Time

[nando161mando]

Most of you are going as this for Halloween. And it doesn't even require a costume.

https://www.reddit.com/r/HermanCainAward/

#COVID #COVIDisNotOver #COVIDisAirborne #COVID19 #eugenics #ableism

[thebisexualwreckoning]

Covid: you only had me for a week, our relationship was short term, I didn’t even hurt you that badly

Me: you ruined a relatively perfectly good set of lungs is what you did! Look at it, i can’t even eat fucking ice cream without them being wrecked so bad my body needs to be put on bed rest for two weeks

[covid-safer-hotties]

Immune cell regulator discovery could lead to treatments for arthritis and severe COVID - Published Aug 14, 2024

The discovery of a new regulator affecting immune cells could lead to new treatments to reduce inflammation in diseases including arthritis and severe COVID 19.

A large research collaboration, led by the University of Exeter's MRC Center for Medical Mycology, has focused on how immune cells sense their environment. This activity triggers responses which are finely balanced, to protect against disease and infection, and to reduce cell-damaging inflammation.

The research, titled "Recognition and control of Neutrophil Extracellular Trap formation by MICL" published in Nature, looked at the behavior of a receptor known as MICL, and its role in both preventing inflammation and protecting against infection.

Lead author Dr. Mariano Malamud, from the University of Exeter, said, "We've discovered that MICL is a key receptor that causes severe inflammatory disease when its functions are altered. This opens the door to the development of new therapies that target MICL, which could reduce the severity of inflammatory diseases and protect against infection."

Most receptors in the immune system sense their environment and send signals to cells, telling them to activate in response to changes such as infection or tissue damage. The team's work has revealed that MICL does the opposite, inhibiting the activation of the cell. This is an important function, as over-activation of cells can lead to cell damage and the development of auto-immune diseases if left unchecked.

The team went on to demonstrate the essential role that MICL plays in regulating inflammation in severe COVID 19, as well as arthritis and some other autoimmune diseases.

The new research, conducted in mice and verified in patients, focuses on the function of MICL present on the most abundant form of immune cell called a neutrophil.

As a result of an autoimmune disease or infection, neutrophils can undergo NETosis, a form of programmed cell death which is key for controlling infections but is very inflammatory. The team has found that MICL is able to detect this, and its inhibitory activity prevents more neutrophils from dying in this way.

NETosis cell death has been linked to several inflammatory diseases in humans, including Lupus, Rheumatoid arthritis and severe COVID. These inflammatory diseases lead to the production of antibodies that bind to MICL, preventing its inhibitory function and resulting in more severe disease.

Conversely, the study showed that increasing NETosis by blocking MICL function can protect against infection, such as those caused by fungi.

In mice with arthritis, the group showed that genetic loss of MICL led to more severe disease due to the excessive formation of NETs. More severe disease also occurred in normal mice when antibodies targeting MICL were applied.

Indeed, more severe disease was also seen in human arthritis patients who possessed antibodies targeting MICL, and the researchers could directly show that these patient antibodies drove exacerbated inflammatory response, using cell samples in labs.

Senior author Professor Gordon Brown, from the University of Exeter, said, "We've been working on how immune cells sense their environment for over 20 years, and this breakthrough is really exciting, revealing how the inhibition of inflammatory processes is finely balanced between controlling infection and the development of autoimmune disease"

More information: Gordon Brown, Recognition and control of neutrophil extracellular trap formation by MICL, Nature (2024). DOI: 10.1038/s41586-024-07820-3. www.nature.com/articles/s41586-024-07820-3

[vizthedatum]

The new 2024-2025 COVID-19 vaccine (USA) is out. It might not be free after this month for uninsured adults (?), and it may not account for further trending variants, BUT YOU SHOULD STILL GET IT.

Hi, y'all! I published a new Substack article because:

The updated COVID-19 vaccine for the 2024-2025 season is now available as of August 22, 2024.

And I have thoughts!

An excerpt from this article:

"The CDC advises that all adults receive this vaccine. The CDC recommends that everyone over six months of age receive this updated vaccine, regardless of previous vaccination status, unless they have contracted COVID-19 in the last three months.

This new vaccine will _allegedly_ remain covered under the no-cost vaccination program, the Bridge Access Program, until the end of next week. (I say “allegedly” because I don’t know.)

But you should call your pharmacy and check!

(I personally booked a COVID-19 vaccine appointment at my local CVS for August 28, 2024. I called the pharmacist earlier today to see if it would be covered under my insurance (UPMC Health Plan provided by my employer, University of Pittsburgh) or the Bridge Access Program). They told me the shipment has yet to arrive at their location, but they think it will be before my appointment and will be covered by either one. However, they can only definitively tell me once they get the shipment.)"

[memenewsdotcom]

Mark Zuckerberg says White House pressured covid-19 censorship

[tumble-tv]

Somehow the pain from having covid is worse than working in retail

[tomorrowusa]

Dr. Anthony Fauci voluntarily testified before a House committee and debunked MAGA Republican conspiracy theories regarding the COVID-19 pandemic.

While Donald Trump and his lickspittles were telling Americans to drink bleach, take useless malaria pills, stick ultraviolet lights up their butts, and eat horse paste, Dr. Fauci headed an effort to develop vaccines for COVID-19.

A reminder to people with short memories who view the Trump administration as some sort of bucolic paradise: The last quarter of that administration included the worst government response to an infectious disease outbreak since 1920. Trumpsters who want us to ignore Trump's horribly botched response to the pandemic are like cruise-liner enthusiasts who want us to ignore the last 2% of the voyage of the Titanic.

Economic activity ground to a halt in 2020 as the US slid into a recession. I took this picture of a sign at a dollar store which had been completely closed for almost two months.

The whole Trump clan was disdainful of the sacrifices hundreds of millions of Americans were making.

Why has the U.S. COVID-19 response been so bad? Jared Kushner, Vanity Fair suggests.

At Times Square Jared and Ivanka's contemptuousness was made into an ad before Election Day.

If you are looking for the Original Sin of Trump's pandemic response, it was on January 22nd when he basically told CNBC's Joe Kernen that COVID-19 was nothing to worry about.

Of course it wasn't "just fine".

Trump did not declare a state of emergency for seven weeks. That gave the virus plenty of time for it to spread throughout the US.

Republicans know that their Dear Leader totally mishandled the pandemic response. That's why they repeatedly try to make Dr. Fauci a type of scapegoat for Trump's horrendous incompetence. Dr. Fauci has spent his entire career fighting disease. Donald Trump has spent his entire career narcissistically promoting himself.

Harry Truman had a sign on his desk saying: "The Buck Stops Here!" If Trump had a sign on his Oval Office desk (which he seldom used except for photo ops) it would be: "It's Everybody's Fault But Mine!"

Don't be hesitant to remind people of how awful 2020 was. And point the finger of blame at the orange blob who was responsible for the catastrophe.

[gumjrop]

The Weather

Twenty-seven US states remain at High to Very High levels of SARS-CoV-2 detected in wastewater since February 28, 2024, with five states not reporting.

Wastewater levels are decreasing throughout the country except in the Midwest. The South is still experiencing extremely high transmission. As a reminder, the last two weeks, shown in gray, are provisional data. These values may change as additional wastewater sites report data.

Despite these ongoing high levels of transmission in most of the country, and in defiance of pleas from civil society to protect the most vulnerable among us, the CDC has once again decided to walk back already insufficient protections – this time in the form of isolation guidance. It announced on Friday at 1 pm that it will repeal the 5-day isolation period for COVID-19 and instead treat COVID-19 like it does other respiratory viruses like flu and RSV, linking isolation length with symptomatology and fever. This policy, of course, is not based on the best evidence–just vibes and a lack of care for those of us still dying (1000s weekly) and still becoming disabled by Long COVID. 

Last week, the CDC recommended that people 65 years and older should receive an updated booster. It did not approve a booster for other people in high-risk categories because they didn’t bother studying the benefits and risks in these groups.

Wins

OK. So it’s been a rough week. But you know what? We are all fighting back. We see you all making calls, creating and signing petitions, joining and expanding Mask Blocs, creating and distributing zines, and making your own air-cleaning systems. We see so many more masked, tested, and ventilated events than we used to! We are mobilizing collective power to keep each other safe and to transform this state. 

Next week, March 11, will mark the 5th anniversary of the declaration of the pandemic. We’re not where we should be, but this pandemic has radicalized a lot of us. Keep connecting. Keep finding your people. Keep going. We will win. 

Oh! And check out these Free COVID-19 and flu test vending machines in King County, Washington!

Variants

JN.1 is still the most dominant variant circulating in the United States and is projected to account for 92.3% of all circulating variants by March 2nd, 2024. Two JN.1 descendants, JN.1.13 and JN.1.18, are now the second and third most common circulating variants, projected to be at 3.3% and 1.8%, respectively.

To check for circulating variants within your community, you can find your HHS Region through the CDC Variant Tracker dashboard.

Long Covid

In an article published in Science, Drs Ziyad Al-Aly and Eric Topol reviewed the perplexing case of Long COVID. They discuss the lack of consensus and systematization when it comes to the classification of the disease, partly due to its different mechanisms and manifestations. For example, younger adult and female Long COVID patients are more likely to be afflicted by fatigue, dysautonomia, brain fog, and post-exertional malaise, while older patients are more likely to deal with cardiovascular and metabolic complications. They also discuss the current potential treatments for Long COVID, but express that since nonpharmaceutical interventions have been neglected, vaccines are the only available therapy. However, vaccines are unable to prevent Long COVID. Ultimately, they state that the only way to prevent Long COVID is by ending COVID transmission, such as by administering pan-variant neutralizing intranasal vaccines.

On March 15, 2024, the Long COVID March will be taking place in Washington D.C. at the Lincoln Memorial. The march is intended to mobilize Long COVID patients and allies to demand acknowledgment and policy changes from the government. You can read the march’s mission statement, which includes a list of objectives. 

Take Action

Join us in demanding the CDC reinstate the 5-day COVID isolation policy. Despite the guidelines having already been dropped, we must still fight for adequate protections from COVID to safeguard our communities from harm. Make your voices known by sending a letter to the White House and your elected officials through our Action Network. The People’s CDC will also be implementing other action items in the coming weeks, so look out for those!

Today is COVID Memorial Day, in which we remember the 1.2 million lives lost to COVID in the United States, and show solidarity with the millions living with COVID grief and Long COVID. Check out Marked by COVID to learn more or to participate in today’s virtual vigil.

Again, we must continue to contact our elected officials to demand a ceasefire in Gaza, and we must continue to wear and require the wearing of high-quality respirators such as N95s and KN95s at protests and within organizing spaces. 

[nando161mando]

Bird flu in Canada may have mutated to become more transmissible to humans

https://www.theguardian.com/world/2024/nov/19/bird-flu-cases-mutation-canada

[toshootforthestars]

From the report by Beth Mole, posted 29 Feb 2024:

In a lengthy background document, the agency laid out its rationale for consolidating COVID-19 guidance into general guidance for respiratory viruses—including influenza, RSV, adenoviruses, rhinoviruses, enteroviruses, and others, though specifically not measles. The agency also noted the guidance does not apply to health care settings and outbreak scenarios. "COVID-19 remains an important public health threat, but it is no longer the emergency that it once was, and its health impacts increasingly resemble those of other respiratory viral illnesses, including influenza and RSV," the agency wrote. The most notable change in the new guidance is the previously reported decision to no longer recommend a minimum five-day isolation period for those infected with the pandemic coronavirus, SARS-CoV-2. Instead, the new isolation guidance is based on symptoms, which matches long-standing isolation guidance for other respiratory viruses, including influenza. "The updated Respiratory Virus Guidance recommends people with respiratory virus symptoms that are not better explained by another cause stay home and away from others until at least 24 hours after both resolution of fever AND overall symptom are getting better," the document states. "This recommendation addresses the period of greatest infectiousness and highest viral load for most people, which is typically in the first few days of illness and when symptoms, including fever, are worst." The CDC acknowledged that the eased isolation guidance will create "residual risk of SARS-CoV-2 transmission," and that most people are no longer infectious only after 8 to 10 days. As such, the agency urged people to follow additional interventions—including masking, testing, distancing, hygiene, and improving air quality—for five additional days after their isolation period. "Today’s announcement reflects the progress we have made in protecting against severe illness from COVID-19," CDC Director Dr. Mandy Cohen said in a statement. "However, we still must use the commonsense solutions we know work to protect ourselves and others from serious illness from respiratory viruses—this includes vaccination, treatment, and staying home when we get sick." Overall, the agency argued that a shorter isolation period would be inconsequential. Other countries and states that have similarly abandoned fixed isolation times did not see jumps in COVID-19 emergency department visits or hospitalizations, the CDC pointed out. And most people who have COVID-19 don't know they have it anyway, making COVID-19-specific guidance moot, the agency argued. In a recent CDC survey, less than half of people said they would test for SARS-CoV-2 if they had a cough or cold symptoms, and less than 10 percent said they would go to a pharmacy or health care provider to get tested. Meanwhile, "The overall sensitivity of COVID-19 antigen tests is relatively low and even lower in individuals with only mild symptoms," the agency said. The CDC also raised practical concerns for isolation, including a lack of paid sick leave for many, social isolation, and "societal costs." The points are likely to land poorly with critics. “The CDC is again prioritizing short-term business interests over our health by caving to employer pressure on COVID guidelines. This is a pattern we’ve seen throughout the pandemic,” Lara Jirmanus, Clinical Instructor of Medicine at Harvard Medical School, said in a press release last month after the news first broke of the CDC's planned isolation update. Jirmanus is a member of the People's CDC, a group that advocates for more aggressive COVID-19 policies, which put out the press release. Another member of the group, Sam Friedman, a professor of population health at NYU Grossman School of Medicine, also blasted the CDC's stance last month. The guidance will "make workplaces and public spaces even more unsafe for everyone, particularly for people who are high-risk for COVID complications," he said.

But, the CDC argues that the threat of COVID-19 is fading. Hospitalizations, deaths, prevalence of long COVID, and COVID-19 complications in children (MIS-C) are all down. COVID-19 vaccines are safe and effective at preventing severe disease, death, and to some extent, long COVID—we just need more people to get them. Over 95% of adults hospitalized with COVID-19 in the 2023–2024 respiratory season had no record of receiving the seasonal booster dose, the agency noted. Only 22% of adults got the latest shot, including only 42% of people ages 65 and older. In contrast, 48% of adults got the latest flu shot, including 73% of people ages 65 and older. But even with the crummy vaccination rates for COVID-19, a mix of past infection and shots have led to a substantial protection in the overall population. The CDC even went as far as arguing that COVID-19 deaths have fallen to a level that is similar to what's seen with flu. "Reported deaths involving COVID-19 are several-fold greater than those reported to involve influenza and RSV. However, influenza and likely RSV are often underreported as causes of death," the CDC said. In the 2022–2023 respiratory virus season, there were nearly 90,000 reported COVID-19 deaths. For flu, there were 9,559 reported deaths, but the CDC estimates the true number to be between 18,000 and 97,000. In the current season, there have been 32,949 reported COVID-19 deaths to date and 5,854 reported flu deaths, but the agency estimates the real flu deaths are between 17,000 and 50,000. "Total COVID-19 deaths, accounting for underreporting, are likely to be higher than, but of the same order of magnitude as, total influenza deaths," the agency concluded.

(say no to raw dough: CDC)

[covid-safer-hotties]

Abstract Cardiac arrhythmias are commonly noted in patients during infections with and recovery from COVID-19. Arrhythmic manifestations span the spectrum of innocuous and benign to life-threatening and deadly. Various pathophysiological mechanisms have been proposed. Debate continues on the impact of incident and exacerbated arrhythmias on the acute and chronic (recovery) phase of the illness. COVID-19 and COVID-19 vaccine–associated myocardial inflammation and autonomic disruption remain concerns. As the pandemic has transformed to an endemic, with discovery of new SARS-CoV-2 variants, updated vaccines, and potent antiviral drugs, vigilance for COVID-19–associated arrhythmic and dysautonomic manifestations remains. The objective of this American Heart Association scientific statement is to review the available evidence on the epidemiology, pathophysiology, clinical presentation, and management of cardiac arrhythmias and autonomic dysfunction in patients infected with and recovering from COVID-19 and to provide evidence-based guidance. The writing committee’s consensus on implications for clinical practice, gaps in knowledge, and directions for future research are highlighted.

[meditating-dog-lover]

Why I think it came from a lab

Note: before you judge me for what I'm about to say, just know I am speaking from a scientific and biological standpoint. I'm a cell biologist who works in virology, and have a BSc in Anatomy and Cell Biology and MS in Neuroscience. I'm a scientist, not your 40 year old conservative MAGA uncle on Facebook. I absolutely hate how the pandemic was politicized as you should never introduce bipartisan nonsense to indisputable and factual matters like science and diseases.

So coronaviruses are nothing new. There have been previous coronavirus strains that infected the world. There is the one that caused SARS in 2002 and the other that caused MERS in 2012. And yes, bats do spread them. They are species capable of zoonotic infections (between species), including rats (spread the bubonic plague) and cattle. However, COVID-19 was a lot more devastating than the other 2 outbreaks. With all the modern knowledge and technology we have on disease prevention/control and vaccines/drugs, the fact that this outbreak was devastating to the point of causing a global pandemic is suspicious. There is no way something as cataclysmic came from nature given our current immunological and microbiological advancements in the 21st century. And judging how bats have spread coronaviruses in the past, it was never this catastrophic.

This leads me to think there was gain of function research involved using animal models in a lab (the Wuhan Institute of Virology). I do have a theory as to how they conducted their research, but it could be wrong. But gain of function research was definitely taking place. I believe they had animals in the lab that were positive for coronavirus (either bats or rats). They took nasal swabs and/or saliva samples from them to be able to harvest cells that had coronavirus RNA replicated in them. One strange thing about some viruses is that they do not possess any DNA. They contain RNA, which is the nucleotide chain that is generated from DNA during a process known as transcription. And most RNA sequences are converted to proteins via translation. Why some viruses lack DNA, however, I never really knew why.

Now in this day and age, we have the technology to modify the sequence of DNA/RNA. This process is known as gene editing. You would have to cut the sequence at specific nucleotide junctions, either insert or remove nucleotides, and then glue the sequence back together. One famous method of doing so is using the CRISPR technique. But there are many other ways to modify DNA/RNA sequences. These modifications do have an effect on the function of the virus. By editing the virus' RNA sequence, you can either cause the virus to weaken (loss-of-function) or to strengthen (gain-of-function). Some modifications lead to no changes in the viral strength and activity. Weakened viruses are used in traditional vaccines, so this is when RNA editing can be beneficial. However, I do believe gain-of-function gene editing was performed in the lab by using the coronavirus RNA sequences harvested from these animals that tested positive for the virus.

This is one theory as to how the gain-of-function research was conducted. There are many ways to do it, we can never be sure as to how it was exactly performed with these coronavirus samples in the lab.

Now how it spread from the lab to the rest of the world, I have no idea. Obviously, infections spread between people who interact with one another. How it expanded from a single lab to the whole world is a complex process to understand.

So this is my theory as a cell biologist regarding the origins of COVID-19. Yes it came from a lab. I fail to believe something this infectious and destructive came naturally from bats. We have the technology and immunological knowledge to aid in minimizing the spread of illness and creating effective drugs and vaccines. Looking at previous trends where bats have spread coronaviruses to other animals and humans, they did not result in global pandemics to this extent. So I think the virus was genetically modified to become more infectious. What was the reasoning behind this? What was the hypothesis they were trying to test? I don't know.

Here in the US, there are strict regulations as what type of research you can conduct in a lab. In theory, you can create almost anything in a lab, from drugs, to explosives, to deadly bioweapons. However, just because you can, doesn't mean you should. While that strictness is enforced here, it is not in other countries unfortunately.

I am devastated by the destruction the pandemic caused. From a single viral outbreak, to illness, disease, lockdowns, crashing economy, closing of small business, politicization of science and biology, anti-Asian hate, etc... Had we had the knowledge beforehand, this would have fared better for us.

[wormeats]

I fell for propaganda and was turned against those I have always wanted to root for

I wanted to send this to the CDC somehow, but the email contact form on their website has a character limit and I'm incapable of being concise. I thought this might be helpful for some people to see because it took me a while to reflect on.

During the COVID-19 pandemic, living in Florida, being young and trans and traumatized by the current political climate and dangers posed by the pandemic, I was swayed by likely a mix of propaganda and a fear and anger response to the amount of stress that time came with. I found myself trusting in the CDC less because of several things that I never fully examined until now recently. It was all just a mix of fear and hopeless rage about public health and my fears about our political climate, and much of that was directed at the CDC. Upon examining this recently, I think this was because I assumed the CDC had more power than it may actually have in enforcing public health. I thought isolation periods could be more solidly mandated, that mask wearing could be solidly mandated, and so on. I assumed the CDC had more control over when schools reopened for children (I now realize a lot of this is controlled by states individually or even more locally), and in my fear of the pandemic and distrust in the CDC sowed by being worried about the country as a whole, I even failed to fully weigh the consideration that virtual learning has a significant impact on Anyone’s mental health and that for children especially, social and emotional development should be fostered and that is an issue that gravely concerns mental health extending to the rest of their lives. I thought the CDC could require employers to keep allowing employees to have sick days when testing positive, so they wouldn't have to make a choice between risking their job and livelihood versus strangers’ physical health and possibly risking permanent damage or death for some with no way to tell (I'm grateful that the risk has been reduced so much by vaccines/boosters and being cautious with masking and washing hands, but I feel it is so important to allow isolation away from work when it concerns transmission and health and recovery). I particularly was swayed more into distrust when I heard that Delta airlines wrote a letter asking the CDC to update isolation periods for vaccinated individuals who would still be required to mask, believing there was no new data to give confidence to such a change in recommendations (10 day isolation period to 5 day isolation and next 5 days with a mask), but found there explicitly was reasoning given on the CDC update from that time available to view on the website’s archives (these have been very helpful because the time of all of this was an emotional traumatizing blur, so specifics are hard to remember). Before I examined this all more after the fact, this led me to believe that the CDC was influenced by economic concerns and the workforce instead of public health and keeping those workers alive and healthy, and furthered my distrust.

I am glad that now I have further examined where this distrust has come from and found that it was irrational on my part, and I regret that I carried on with this tainted view of the CDC for so long. I have struggled with this because I did have a strong trust in the CDC and felt more unsure of where I should find reliable information, knowing the CDC certainly has more expertise than I and has likely devoted a lot of time and research to any particular consideration I might come up with. I hope if others were similarly swayed by political propaganda that sought to utilize fear and stress from the pandemic, that they too come to reexamine how they came to think that way and find trust in this institution of scientists who are clearly passionate about public health and finding ways to keep all of us safe with many unpredictable variables to consider. I feel very ashamed that I allowed my trust in the CDC to be shaken to this extent. I hope scientific research, public health concerns, environmental concerns, and any crisis that requires humanity to understand facts and cooperate is taken more seriously and listened to from experts in each respective field and not turned into political opinions one way or the other. I am so devastated by all the damage COVID has done that feels like it could've been so preventable if this didn't become a political issue and remained a public health crisis to work through cooperatively. I have now come to see that I think the CDC did as much as it could through all of this with all of the consideration at the time and with its limited influence amidst political stress.

Thank you everyone at the CDC, I am sorry that I fell for this propaganda, and I would like to talk to as many people in my life about addressing propaganda and fully considering that no one is fully safe from falling prey to propaganda and biases we don't realize are tainting our full view. Thank you again so much for everything incredible that you have done for humanity. Be kind to yourselves everyone, shit has been so hard honestly.

[thechronicpaingame]

Covid update day 12 - first day negative.

I have and am continuing to have, a rough time. Doctors think I have pneumonia & pleurisy. Waiting on bloods & x-rays. I have more pain, more fatigue, constant chest pain that worsens on any exertion, breathlessness beyond my asthma. I don't know if / what will continue but fingers crossed I at least recover to my "normal" baseline.

I've managed to stay out of hospital (besides the asthma attack I posted about previously) and unless I really take a turn for the worse I don't plan on it before Christmas. I'll do anything to stay home.

It's just a matter of rest, rest and more rest for the foreseeable. I envision it being at least a couple of months to fully recover (I hope).

Look after each other. If you can, protect yourself from this ♥️