#3d bandage
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nyaskitten · 7 months ago
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I know no one gaf but I love how no matter when we see them, the Forbidden Five are always in the same positions.
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octogirlscreations · 7 months ago
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Sometimes, to pull up memories, all it takes is a photo.
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For some. It reminds them of the good times.
…for others. It reminds them of Their their Trauma.
(We Delving deeper Into the past here. More will be revealed soon)
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gumbuk9 · 9 months ago
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idk if you listen to femtanyl, but could you make the femtanyl creature in blender? thanks!!!!!
sorry for taking like a month to reply to this i was doing this on and off and got burnt out in the middle and was working on this in parallel with some other things and it's still not done yet probably but as of now here it is
i tried
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all in all this model was a pretty decent learning experience for blender functionality i never touched before; like rigging, shape keying, and rendering (rendering iv'e partially touched)
under the cut; 11 renders, 9 editor screenshots, 2 editor gifs, and a lot of text
base pose
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fuckem!!!!!
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leaning forward
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jump for joy (with & without torn off ear)
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death
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lab animal finds camera
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"hey girliepop how many times did you hit your head against the ceiling girder today?"
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i don't know what to call this
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hiiiiii!!!! heyooooooo!!!!!!
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(extra nerd shit inbound!)
full scene tree
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i'm very new to posing and as such am pretty bad at it
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everything is split into individual segments because of how i chose to do things
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i was planning to add a face with different frames for eyes & mouth you could mix and match but i didn't have the time, mental capacity, and confidence to do it, but i might update this model later with more things including a face
a friend said she doesn't need a face and i agree but i don't stop thinking about it
closeups of the "emo" details (this was a suggestion by a friend)
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closeups of the bandage & suture
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do people even read this far into these long ass posts? let me know if you do or something
also let me know if you'd like me to do anything with the model, like make an extra pose or add more optional cosmetics i guess, i'll try to follow through with it as best i can,
i'll post updates on this model in a reblog to this post most likely, look out for that i guess
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frogs-in3-hills · 3 months ago
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honestly i would have liked aa5 apollo significantly more if they hadn’t given him that weird shounen boy design
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hylianengineer · 2 years ago
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I’m procrastinating a lot today
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beansprean · 2 years ago
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Izzyhuahua is the most insanely accurate characterization yet. Thank you @batsarebetterthanpeople for your post.
(ID in alt and under cut)
ID: 1a. Ed, in a modern black tee shirt and jeans, walks in a door that dings when he opens it. He has a square shaped cloth shoulder bag strapped over his chest that is decorated with skulls and embroidered with "Izzy" at the top. Popping up from inside is a dark brown long haired Chihuahua with white on his muzzle, spots on his head that look like angry eyebrows, and a spot on his cheek that looks like an x. 1b. Ed from the back as he holds up dog Izzy with both hands, saying, "you're gonna have to sedate him." Lucius, dressed as a vet tech in peach scrubs and a red kerchief, holds out his hands to take him with a smirk, responding dismissively, "Haha, don't worry! Dr. Bonnet can handle this little guy." Izzy growls softly. 1c. 10 minutes later. Lucius reappears, hair missed, clothes torn, and a bloody bandage around his left pointer finger. He holds out a form on a clipboard and says, "Yeah, we're gonna need to sedate him."
2a. Close up on Stede, dressed in teal scrubs with a stethoscope around his neck, on a bubbly yellow background. He looks up, eyes widening and cheeks turning red, mouth soft as he fumbles through an introduction, "Hello, I'm Dr. ...uh.... Stede..." 2b. Reverse close up of Ed in a similar state, staring lovestruck and blushing as he responds dazedly, "...Ed..." 2c. Close up on Izzy as he furiously launches himself upwards, growling and snarling! Offscreen, Ed screams, "Ahh, fuck, Izzy, no!!" and Stede shrieks, "Oh God!!" and calls for Lucius.
3a. Later, Izzy is now out cold on an examination table, snoring and tongue sticking out but somehow still looking angry. Text nearby points to him and says "extra extra drugs". Ed and Stede stand on either side of the table, Ed gently petting Izzy's back with a smile as he explains, "He has a lot of separation anxiety... I'd just like him to stop biting people, haha." Stede, arms crossed, looks down skeptically at the dog and just replies, "Right." He thinks to himself, 'Diagnosis: complete asshole.' 3b. Ed looks down, blushing a bit, and continues, "Makes dating kinda tough, heh." Stede immediately perks up but tries to keep it casual, looking everywhere but Ed and sweating at his temple. "oh?" he ventures carefully. "You're single, then?" Ed sighs, replying, "Yeah. Iz here has run off my last two boyfriends." 3c. Ed looks up at the ceiling, playing ignorance, and taps his chin facetiously, wondering aloud, "But maybe if I found someone good with animals...who understood-" Stede, looking sweaty and panicked, interrupts him at top volume with "Do you want to have dinner with me?!" 3d. Stede drops his tomato red face into his hands, mumbling, "I'm sorry, that was so unprofessional..." Ed just beams at him from the other side of the table, clearly having gotten the invite he was fishing for. On the table, Izzy starts to twitch and wake, one angry eye cracking open.
4a. Stede and Ed on a black leather loveseat in Ed's home, mismatched candles the only source of light on either side of them and music drifting sensuously from a speaker. Both are clearly dressed for a date, Stede in a button up and khakis and Ed in a purple henley and gray trousers. They are leaning close, knees interlaced, Ed's hand on Stede's thigh and the other cupping his cheek, Stede with one hand stretched on the back of the couch and the other expertly cupping a wine glass. Their faces are an inch apart, eyes closed, about to have their first kiss. 4b. There is a happy "yip!" as Izzy suddenly jumps up into Ed's lap and places his little paws on his chest, breaking the moment and causing Ed and Stede to jerk back from each other in surprise. 4c. Ed laughs and wraps his hands around the little dog, hearts floating up as he coos, "Aww, Izzy! Did you need some attention?" Unnoticed by Ed, Izzy turns to look at Stede over his shoulder to aim what can only be called a triumphant smirk at him. Stede jerks in surprise and looks immediately offended and angry. /end ID
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cloudberrylane · 2 months ago
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layla-sims · 10 months ago
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RUTH & MAXIMUS | CC LINKS
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....OK OK ILL MAKE MASCULINE MALE SIM NEXT TIME.....BUT I LOVE SENNIS CUTE BOY PRESETS !!!! day 1 without the heavy rain gshade preset...i lost hearing in my right eye... should i change my pfp?!?! SCROLL FOR CC LINKS <3
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MAXIMUS
Hair: Sen Hair
Skin Details: Fleur skinblend Sakura Blush 3D Eyelashes
Makeup: Sleepy Blush Eyeliner Affliction Eyes
Clothes: Hello Kitty Mistakes Puffer Flame Skirt Pixie High Thigh Garter
Extras: Newrocks Socks Sick Tats Kiss Piercings Lip Piercing Saya Ears Didn't Ask Piercings
Extras n2: Cas Background Gshade Preset
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RUTH
Hair: Saya Hair
Skin Details: Myrica Overlay Sakura Body Blush Puppy Tapes Mercy Eyebags Face Kit
Makeup: 3D Eyelash Pouty Lips Eyeliner N95 Shy Doll Blush Fawn Set
Clothes: Salem Dress Bratz Heels
Extras: Cafe Tat Bandages Jade Eyes Regret Piercings Fawn Set Tattoo Belt Set
<3 <3 <3 <3 <3 <3 <3 <3 <;3 <3 <3 <;3 <3 &lt;3 <3 &lt;3 <3 @flowermilksims | @jellypawss | @simandy | @atomiclight | @pralinesims | @dream-girl | @dumbabieee | @kindlespice | @babyetears | @1-800-cuupid | @scaroh | @gigglecoffin | @starcaller-senni | @regina-raven | @baddiesims | @pyxiidis | @mmsims | @nesurii
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zumazozuma · 7 months ago
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Hey. FMA Fandom. I freaking did it ok.
Lan Fan's *FULL* automail design from the manga? Yeah. It now finally exists.
Please accept this humble offering as fanon:
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NOW EVERYONE DRAW HER!!!
ARAKAWA I HOPE YOU'RE PROUD!!!!!!!
Edit: I thought I'd leave some manga panels to point out a few things I don't have the skills to successfully translate in this ref sheet!
Explanations under the cut!
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The armor plates on the shoulder are bigger than what I drew (I tried to put them at an angle but they just look smaller lol) I recommend just enlarging the top plate from the middle! It's supposed to hide most of the upper arm.
If you draw her in full uniform, she of course has bandages and that cool spiky leather strand around her wrist. The spiky knuckles appear to be a separate accessory as well.
The automail isn't all open right on top of the forearm, but on its side, as you'll see in the manga panels. I should've drawn the hand seen from the side but I wanted to show the screw on top of it beheheh.
The thought process behind Lan Fan's automail appears to focus on being as light as possible so that she can keep fighting with speed. Compared to Ed's very solid and armored automail to be as enduring as possible, Lan Fan's trades durability for lightness!
The mechanism for the hidden blade is basically just rings inside the fingers, to which are attached wires that are tethered close to a tiny hook. My thought process behind this is that we most likely want to avoid accidentally unsheathing the blade, so LF has to literally reach for it! It's a safety measure, but I also like that it makes her do a hand move kinda similar to Scar's whenever he's about to use his alchemy/alkahestry destruction for an attack!
For the port, have fun with it! I tried my best to give it an interesting look but I struggled with giving it a 3D metal feel. I focused more instead on where the support would be since the port can't be drilled on most of the chest. Drilled on the back it is!
Finally, if you notice the tiny lock I inserted in the simplified design, no it's not made to render the arm immovable; rather it's just there to secure the automail in the port. You know, during the process to connect the nerves. You attach the little wires, screw the bolts, and lock it all in neatly!
With this, I hope everyone will have fun drawing Lan Fan's full automail! It may not be canon, but it's at least better than nothing! So many art pieces just hide her automail because of that lack of reference, so I hope I helped change that!
(Note: the scars I gave LF on her right shoulder and left side aren't canon either. I saw an art piece way back when and somehow convinced myself that I just had never noticed in the show lol. But you can't tell me the bodyguard to a prince that canonically survived a bunch of assassination attempts wouldn't have a scar or two!!)
NOW DRAW YOUR HEARTS AWAY!!!
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spocks-kaathyra · 1 year ago
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how did you make those holy shit!!!
jfjskdk okay I'll take any excuse I get to talk abt this more
How I made my Cardassian prosthetics
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Disclaimer: I'm no expert, it's my first time doing this!! All the resources I used can be found online. In fact, here's a playlist of all the youtube videos I followed, in case you don't want to read the whole post. You can pretty much make any facial prosthetics following these steps, not just Cardassian ones.
What you'll need:
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Plaster bandages, plaster of Paris (a lot more than is pictured here), modeling clay, and liquid latex. You'll also need some things you probably already have around the house, like vaseline (or cooking oil), plastic wrap, wood glue, rubbing alcohol, q-tips, cotton balls, and setting powder (or baby powder).
Step 1: Face cast
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The goal here is to make a plaster copy of your face that you can sculpt your prosthetics on, by covering your face with plaster bandages and then casting that in plaster of Paris. This is the video tutorial I followed for this step. There are many methods, and you'll find tutorials for all of them on youtube, but this is the easiest way if you're doing it by yourself, and it results in a perfectly useable face cast for our purposes. And, if you're cosplaying Garak like me, it's a great way to get into character by experiencing claustrophobia for the first time in your life!! (Jk it's not actually that bad. I lived.)
The video explains the process better than I could, but here's some tips I learned from doing it! Wear a shirt that you don't mind ruining. Go a bit closer to your eyes than I did here. When you're propping up your mask in a bowl, make sure you're not squishing any parts of it or tilting it! I ended up with a dent in the chin of my face cast because I accidentally dented the mask while I was casting it. And make sure you have enough plaster of Paris! I probably used 2-3 pounds for this part. Here's what I ended up with, before sanding or sealing it with wood glue:
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Step 2: Sculpting
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This is pretty self explanatory, but also probably the hardest part. Just use lots and lots of reference photos. I've got a pretty good stash for Garak, if anyone's interested hdjkfhk. I found that gifs made better references than still photos, since they give you a better sense of the 3D shape. You want to make sure you're using modeling clay that doesn't dry. You don't need any fancy sculpting tools! I used my trusty palette knife to get the small details, but you could probably accomplish the same thing with, like, a spoon and a toothpick. It depends on what kind of clay you're using, but you can dip your finger in a solvent to smooth out the surface of the clay and blend the edges into the face cast. I used rubbing alcohol, but I also heard people recommend acetone. Once you're happy with your sculpt, you can move onto the next step!
Step 3: Casting negatives
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This step is technically optional. The video I followed also outlines an easier way that skips this step, by simply building your prosthetics directly on the sculpt. But casting negatives allows you to get a lot more fine detail, and a smoother finish on the final prosthetics, so that's what I chose to do. Basically, you pour plaster of Paris over your sculpt, and it hardens into a mold you can use to build your prosthetics on.
Again, the video explains it better, but some tips! If it's possible with your sculpt, do it in small pieces instead of the whole face at once. I did the chin, nose, and forehead separately. If you try to do the whole face, there's a greater chance of it getting stuck or breaking. Of course, if you were doing, say, Odo, then it might not be possible to do it in multiple pieces. Another thing to watch out for:
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If your underlying face cast has any "undercuts," or places where it's, like, concave, then if plaster gets into those areas and hardens, your face cast and your negatives will lock together, and you won't be able to use either of them. For me I was worried about the sides of my nose and under my bottom lip. As long as those parts are filled in with clay, then you should be fine. It's okay if your clay sculpt has undercuts! You can see in the (shamelessly stolen) diagram that their sculpt has a lot of undercuts, but that's okay because the clay is soft and won't lock with the plaster, it'll just come off. The video I got the diagram from was also pretty helpful, even if it's meant for casting with different materials than I used. Here are the completed negatives:
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Step 4: Making the prosthetics!
Now you have negatives! Your sculpt may or may not be intact, but if your negatives turned out okay then that's fine. This step is also covered in the video for step 3. Using a stippling sponge, foam brush, or q-tip, stipple thin layers of liquid latex onto your negatives. I found that a q-tip worked best, even if it took longer to cover larger areas. Make sure the edges are very thin, so you can blend them into your skin when you apply the prosthetics. Wait for a layer to dry before adding more latex on top of it, or you'll end up with fucked up results like I had:
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(Left: first draft, where I didn't let it dry enough before layering more. Right: second draft. Much better!)
Build up bulky areas with pieces of cotton balls, then cover the cotton with a thin layer of latex. Emphasis on thin! It'll take forever to dry if you saturate your cotton with too much latex. This step mostly involves a LOT of waiting. When the latex is fully dry, brush everything with a liberal amount of setting powder or baby powder to prevent the latex from sticking to itself as you peel it out of the mold.
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And now you have your prosthetics! You can tear away some of the excess latex at the edges to make it fit your face better. I ended up tearing away almost all of the edges around the eye ridges, so it would blend better and I wouldn't have to get adhesive so close to my eyes. Tear, don't cut! It'll result in a more natural edge that's easier to blend. This video shows how to apply prosthetics. Use whatever prosthetic adhesive you want! I used spirit gum because it's what I had on hand.
Now you can go forth and live out your lizard alien dreams!!
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hewkii · 3 months ago
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Acht (Dedf1sh) Cosplay Rundown
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feel free to copy or take inspiration :]
assembly instructions and print settings/materials for 3d printed parts are on thingiverse (headphones) (other parts)
models designed by me are in brackets in the materials list
Hat/Tentacles
black trucker hat with blank white front panel
[dedstencil.stl]
fabric paint
shiny indigo fabric
less shiny white fabric
glow-in-the-dark pigment powder
polyfill
metal marbles (to weight the ends so they hang properly)
two of [octosucc.obj] in different sizes
acrylic paint
conveniently enough i've had this hat hanging on my door for years. i got it with N from pokemon in mind but i never actually did that cosplay ¯\_(ツ)_/¯
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here are the sketches i based my patterns on (1 square=1 cm). don't forget to add seam tolerances
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Headphones
full details on thingiverse (mudmouth not included)
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Arms
mesh bolero with built-in gloves
rit dye
fabric paint
10 of [finger_claw_vase.stl] in varying sizes
i wear claws under the gloves, but sometimes i'll wind up taking them off after a while since they can get uncomfortable and they make it hard to use my phone :/
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Bracelet
[acht_bangle_vase.stl]
acrylic paint
glow-in-the-dark pigment powder
glossy clear coat
a cut up mello yello bottle
packing tape
eva foam
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Misc. Doodads
red mirror shades
color chips
necklace chain
[acht_tag_jelleton.stl]
[acht_tag_ident.stl]
[acht_tag_hook.obj]
did you know that acht gives eight a mobility chip in the trailer but a power chip in the actual game? bc i didn't notice until after i'd already finished making the mobility one. so i've got a spare chip i guess
the dogtags were kind of a spur-of-the-moment creative liberty. i had the jelleton one sitting around from some experiments with composite filaments, and while i was brainstorming a way to incorporate acht's cool fish hook into the cosplay without needing to actually get my ears pierced it all sorta clicked together. i made the ident tag shortly afterwards and swiftly forgot what the text says :P
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the rest of it
dress tunic thingy
metal eyelets
red string
camo pants
combat boots
i skimped on accuracy in favor of comfort for the lower half ¯\_(ツ)_/¯ the dress is more of a shirt, i added comfy pants bc i hate wearing colored tights (or god forbid painting my thighs green), and shorter boots bc more accurate ones are expensive as hell. plus any heel higher than this makes walking feel like playing qwop (skill issue). speaking of which does it bug anybody else how long acht's feet are on their in-game model or is that just me
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idk if it counts as part of the cosplay but i also add a leather jacket when my arms get cold. i think it goes hard
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To-Do:
ink the shaved streaks onto the hairnet
swap out the red leather cord for something less stiff
see if beans would work better than marbles
hand bandages?
single pointy tooth?
make a pre-sanitized version so i don't have to scrub off face paint every time
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crowfanity · 2 years ago
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Finally decided to make some Ace Attorney textposts of my own!
Part 1 | Part 2 | Part 3
(ID under cut)
[ID: a series of nine textpost screenshots with character sprites from Ace Attorney to the right of them
First pic: a tumblr screenshot that says "You're unable to [pleading face emoji] out of the one whore." Next to it is a picture of Blackquill glaring and an opaque picture of Bobby Fulbright/The Phantom’s sprite making a similar expression to the emoji. The first comment replying to it says “can’t tell if this is meant to be sexual but i immediately imagined the irs saying this to me” with a sprite of Phineas Filch smiling next to it. The comment after that says “i’d love to study you”. Next to it is Athena Cykes’ sprite making a displeased face and sweating. End of first pic ID.
Second pic: a tumblr screenshot that says “of course, the best part of any character’s corruption arc is their cool new outfit” next to a sprite of Apollo Justice in Dual Destinies with bandages over his eye and arms and a blue jacket over his shoulders. His arms are crossed and he looks upset. End of second pic ID.
Third pic: a screenshot of a twitter post in dark mode. The tweet says “trust me i know everything i just can’t form a coherent sentence” with a picture of Sebastian Debeste with his arms out looking smug. End of third pic ID.
Fourth pic: a screenshot of a tumblr post saying “Best type of character causes at least 50% of their own problems and then cries about it” with a picture of Ron Delite looking with his hands tucked against his chest, looking like he’s about to cry. End of fourth pic ID.
Fifth pic: a tumblr screenshot that says “I’ve figured it out” in all caps. Then continues in lowercase: “my all time favorite character archetype is: guy who goes ‘i am the smartest boy. in the whole entire world’ and then immediately eats shit and dies”. Next to it is a picture of Miles Edgeworth with his hands out, looking smug, along with a smaller sprite of him from Investigations laying face down on the ground. End of fifth pic ID.
Sixth pic: tumblr screenshot that says “bitches say they’re fine and then scream the “I sometimes wish I’d never been born at all” in bohemian rhapsody louder than everyone else. Next to it is one of Apollo Justice’s sprites from Dual Destinies wearing bandages over his eye and arms with a blue jacket over his shoulders. His arms are crossed and he is looking at the camera with a determined expression. End of sixth pic ID.
Seventh pic: a tumblr screenshot saying “Guy at the bar keeps trying to pick a fight with you and when you turn him down and say you don’t want to take it outside he busts out the biggest, saddest, most shining puppy dog eyes you’ve ever seen. Next to it is two of Wocky Kitaki’s sprites. The first one is of him leaning forward with his elbows out and hands behind his back, looking intimidating. The second sprite is of him standing up straight and looking sad. His irises are noticeably bigger from the first sprite. End of seventh pic ID.
Eighth pic: a cropped instagram screenshot of a ceiling with text that says “just a heads up if I act dumb i’m joking. i’m 100% smart and know literally everything”. Underneath the text is a sprite of Sebastian Debest with his arms out looking smug. End of eight pic ID.
Ninth pic: a cropped screenshot of a tiktok video with text in the center. Behind the text is the top of someone’s head with a house, a bush, and a tree in the background. The text says “if y’all ever need me, just know i’m only about 5 missed calls & 3 text messages away” with two heart emojis before continuing to say “i’ll always be there”. Next to it is Phoenix Wright’s 3D sprite smiling at the camera with a hand on his hip. End of ID]
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my-horns-think-im-tall · 1 month ago
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" Uh, hiya..!..still figuring this out... "
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"Hi, I'm Apollo Justice, and...that's it, I think?
I'm a defense attorney working at Wright Anything Agency."
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ooc: APOLLO!!! APOLLO!!!!!! APOLLOOOO!!!!!!!!!!
extra info: there's already an apollo/klavier blog!! go show them some love too for me why wont ya ( @thepollyjustice & @rockgodklav )
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Info about Polly:
he/him (subject to change if i feel like it)
timeline tbd, but klapollo will be the main ship here as my partner will hopefully make a klavier blog :3
mod has not finished dd/soj yet! i’m on turnabout academy in dd currently, but i have finished aj:aa :3
i will be basing my knowledge off the wiki and the game as i play/watch it, but i can't guarantee a full in-character response (sometimes regarding other characters) D:
list of hcs at the end once i add it!!
this will be mainly an ask blog for now, but i might poke in the rp blog territory if i feel like it! :3
i will alternate between apollo's 2d/3d sprites and use whichever one i see fit, but please specify if u want bandaged apollo or apollo in a certain time period or sm
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Info about meeee:3
main account is @bitesizedgummie (i mainly post aa stuffs :p)
he/they!!
I AM A MINOR!!!! this is different for others, but please don't direct NSFW towards me OR character blogs. >:(
call me pickle, gummie, astro, apollo, or wtv floats ur boat!!! :3
non-weird interactions are always welcome, even with non-fandom characters!!
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hcs loading lolol
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scifimedic · 4 months ago
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Hi! I just found your blog and noticed you have some posts where you explain how to write certain medical conditions, and I was wondering - could you perhaps do a post on blood poisoning, please? I am struggling with it a little lol.
I have a character that got stabbed, and I don't know what are the odds they could get blood poisoning and if yes, how fast and generally how it progresses.
If you don’t have time or something, don't sweat it, it's just a silly idea I got lol :D
Episode 4 of SciFiMedic Explains: How do I write sepsis?
Hi Anon!
So, your character got themselves stabbed, huh? Before we get to the nuts and bolts of how this is going to progress, we have to clear up a little choice of words here. 
The term blood poisoning is not the medically correct term for an infection inside the blood- we call it sepsis. Unless you meant literal poison from the weapon (which I can do a follow-up post on, if that’s the case) I’m going to guess that we’re talking about a severe, system-wide infection of the blood. 
Let’s walk through a few options: 
Scenario 1: 
Your character is stabbed in an area with lots of big blood vessels (highlighted red in diagram), and while everyone does all they can, the poor guy quickly dies of blood loss. There’s no time for infection to set in. 
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Scenario 2: 
Your character is stabbed in a non-lethal area, like the arms, legs, or shallowly on the gut (highlighted green in diagram) They’re able to bandage themselves up, or maybe someone helps them out and they manage to get the bleeding stopped. 
Unfortunately, 12 hours later, they notice red streaking coming from around the wound. They also: 
Feel freezing cold, but have a high temperature
Are dizzy
Are shivering
Can’t quite catch their breath and feel the need to pant
Throw up
Look pale
These are all signs of the injury going septic, which is when the infection spreads away from the site of the wound and into the bloodstream. It happens fast. From the onset of these symptoms, they can be dead within only 12 hours. 
Here’s what needs to happen for them to survive: 
1: Hospital. No buts, no delay. If you want them to survive, they need advanced medical treatment, detailed below. (I will allow for a field hospital, or a makeshift hospital with a trained professional and plenty of supplies.) 
2: Blood and wound cultures. This means taking a small tube of blood from the arm, rubbing a cotton swab in the wound, and then sending both samples to the lab for study. They will smear the sample on a slide, put it in a warm, wet environment, and wait for it to grow out. Then, they’ll pop it under a microscope and run chemical tests on it to find out what the infection is. This process can take up to 4 days. The good news? The more pathogens that’s in the sample, the faster it will grow out. If you have blood that is severely infected, it could take as little as 12 hours to see results. (I know this from personal experience.) 
If you’re in a field hospital, unfortunately this is a luxury you don’t have. See next step. 
3: IV antibiotics immediately. Since you don’t know the bacteria causing the sepsis, you don’t know which antibiotic to give. Good news, people a lot smarter than I have created a plan for this. 
3a: According to this study done by the National Library of Medicine, 67.9% of people presenting outside a hospital setting had their wounds infected with either Staphylococcus aureus or Pseudomonas aeruginosa.  3b. Thankfully, we have two very strong antibiotics- Vancomycin and Ciprofloxacin- that can each treat these pathogens. Unfortunately, each antibiotic is effective against only one of these pathogens, and nearly useless (or has developed resistance) against the other one!  3c. Good news, these antibiotics can be safely run together. Boom, you’ve just slammed (and it’s a slam- these drugs are horrible for you long term) 67.9% of patients with the right antibiotics to start treating their sepsis.  3d. What about the other 32.1% you may be asking? Good news, they’re not doomed. Just because a given antibiotic isn’t the best choice against a certain pathogen, it doesn't mean it will be completely ineffective. You may be buying them more time for the cultures to come back. You can also take your next best guess, and switch the antibiotics after a few hours if they aren’t having any effect. 
4. Fluids. IV time! The biggest tell that someone has sepsis is that their blood pressure plummets to dangerous levels (which is what will eventually kill them, but we’ll get to that.) In order to prevent that drop, we need to raise the blood pressure by adding more volume to the blood through fluids. They might also need a blood transfusion, depending on how much blood they lost from the initial stab wound. 
It’s important to note that it may not be possible to gain IV access, because when the blood pressure is that low, the veins tend to shrivel up and disappear (not literally.) In that case, your next best option is an IO, which is a needle drilled into the center of the upper arm bone, or lower leg bone. Yes, it hurts. 
5. Vasopressors. Fancy name for medications that force the blood pressure to come up. There are four main pressors: 
Norepinephrine
Epinephrine
Phenylephrine
Vasopressin
They should be added in that order, although this article admits there isn’t too much hard evidence to back this up.
It’s important to note that this is ICU level care, and unless we’re in the middle of the woods, we will have transferred there.
How do you know if it’s time to add another pressor? You’re not getting the results you need- AKA the blood pressure is continuing to stay or fall too low. In the ICU, we use a different measure of blood pressure that most people aren’t as familiar with, called a MAP score. It’s easy, I promise. 
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We use this method because it’s more representative of the amount of blood actually getting to the organs- though that is debated quite a bit in various circles. In America however, that’s the way most ICUs do it. 
The ultimate goal for a sepsis case is to have a MAP above 65 mmHg. You can use this calculator to play around with the numbers and see if the blood pressure you’re thinking is within those parameters. If it’s not, time for another pressor. 
At this point, your character is passed out most of the time. They’ve got a high fever, rapid heart beat, and are covered in sweat. They might also have a seizure from the fever and general stress on their body- at the very least they’ll be shaking from the chills. Their skin will be very, very pale, and might look kinda blue or gray in places- kinda like spots. 
6. Hold your breath. No, not literally. But at this point, you’ve done all you can and you have to wait for them to either get better, or get worse. 
If they get better, they’ll slowly start to maintain their own blood pressure, the fever will come down, and they’ll be able to string a coherent sentence together again. Recovery from sepsis can take a long, long time- as many as two to four months in the hospital. It totally depends on the person and how strong they are. The fittest, luckiest patient I’ve seen recover from sepsis was with us in the ICU for three weeks, then spent another month in a step down unit doing various therapies to regain strength. 
However… if we’re looking at failure… well, then it’s time to move onto scenario 3. 
Scenario 3: 
After completing all of the above steps, they end up getting worse. Don’t worry, it’s not your fault- sepsis is fickle and kills fast. At this point, their kidneys are starting to fail from the inadequate blood pressure- you’ll need dialysis for that. They might stop breathing, or be unable to oxygenate their blood properly, then they’ll need a ventilator. At this point, they’re not stable enough to go into surgery anymore, so there’s no hope there. Eventually, the high fever will cause seizures, which will lead very quickly to brain death. As little as 12 hours after the initial dizziness and red streaks, their heart stops and they’re pronounced dead. 
Summary: 
The odds of your character developing sepsis from a non-fatal stab wound without immediate medical care are high- 90% 
If they’re rushed to a hospital, their odds are better- 50%
If they do develop sepsis inside a hospital, they’re likley to survive- only 10.55% of people die of this kind of wound infection.
If they develop sepsis outside a hospital, then it’s almost certain they will die- 99% 
Disclaimer: Although I’m in school to become a medical professional, I’m not one yet. All mistakes are mine, and I’m always open to discussion.
Anon, this was a fun prompt! If this isn’t quite what you were looking for, feel free to submit another ask with more follow up questions!
Everyone else, also feel free to send me an ask, or reblog this (or any SciFiMedicExplains Episode) with a scene you’d like me to help you write!
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vyssims · 5 months ago
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beakers-and-telescopes · 1 year ago
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Our body is is naturally very good at healing. When we get injured, the first thing our body has to do is protect the wound. Platelets help clot the blood and stop your bleeding, and white blood cells work to clear debris and fight off bacterial invaders. Then the real healing begins Our white cells produce extracellular vesicles (EVs) that act as our body's "construction crews", promoting blood vessel formation and reducing inflammation as the tissue recovers.
Most of the methods we use to treat injuries to the skin involve helping out the body during the first stage- stitches to keep the wound closed and stop bleeding, antibiotics to help kill bacteria, and bandages to keep dirt and debris away from the healing wound. But a research team developed a new form of wound therapy designed to help expedite the second stage of healing.
PAINT, or portable bioactive ink for tissue healing, works not by clearing the environment to make the body's work easier, but by delivering additional EVs, or construction crews, into the body. The EVs are harvested from macrophages, a type of immune cell that digests debris and pathogens in the body. The EVs are mixed with a hydrogel for stability and then "painted" onto a wound with a 3D printing pen, forming a solid gel in about 3 minutes. Here is a video of it in action!
The EVs were tested on injured mice, and found that they significantly promoted the development of collagen fibers and accelerated the healing process. Here is an image of a simulated wound after 14 days of healing with no intervention and with 2 different concentrations of PAINT.
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With more development, this technology could be instrumental to healing major wounds to the skin with minimal intervention.
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