#there is STILL A FUCKING PANDEMIC

[faerociousbeast]

homophobia sucks

[disasterhimbo]

He should NOT be at the club! There’s an airborne pandemic still killing thousands and disabling millions weekly

[potatobugz]

I CANT BELIEVE PROFESSOR CHAOS IS AN NFT GUY.

[covid-safer-hotties]

Also preserved on our archive

Whenever you hear someone trying to blame kid's poor test scores "post pandemic" on "lockdowns," show them this.

By Dr. Sushama R. Chaphalkar, PhD.

New research shows that mild COVID-19 alters brain structure and connectivity in key areas responsible for memory and cognition, emphasizing the lasting effects on young people’s brain health.

In a case-control study published in the journal Translational Psychiatry, researchers used magnetic resonance imaging (MRI) and cognitive tests to examine brain structure, function, and cognition in adolescents and young adults with mild coronavirus disease 2019 (COVID-19) compared to healthy controls in a pandemic hotspot in Italy. They identified significant changes in brain regions related to olfaction and cognition, with decreased brain volume and reduced functional connectivity in areas like the left hippocampus and amygdala, which were linked to impaired spatial working memory. Notably, no significant differences were observed in whole-brain connectivity, suggesting that these changes were localized rather than widespread.

Background COVID-19, primarily known for respiratory symptoms, also affects the central nervous system, leading to neurological issues like headaches, anosmia, and cognitive changes. MRI-based studies reveal anatomical brain changes in COVID-19 patients, such as reduced gray matter and decreased volume in regions like the hippocampus and amygdala, often linked to cognitive deficits.

While research mostly focuses on severe cases and older adults, a majority of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, occur in adolescents and young adults who also experience long-lasting cognitive symptoms.

This age group, undergoing key brain development, is impacted by changes in spatial working memory and brain structure, which are crucial for cognitive functions shaped by social interactions, significantly disrupted by the pandemic.

Given that this is the largest and most understudied population affected by COVID-19, understanding the brain and cognitive impacts in adolescents and young adults is vital.

Therefore, researchers in the present study compared anatomical, functional, and cognitive outcomes, utilizing a longitudinal design that allowed them to assess both pre- and post-infection differences, in COVID-19-positive and negative adolescents and young adults from Lombardy, Italy, a global hotspot during the pandemic.

About the study The present study involved participants from the Public Health Impact of Metal Exposure (PHIME) cohort, a longitudinal investigation of adolescents and young adults in northern Italy. Between 2016 and 2021, 207 participants, aged 13 to 25 years, were included in a sub-study with MRI scans and cognitive tests. After COVID-19 restrictions were lifted, 40 participants (13 COVID+ and 27 COVID−) participated in a follow-up study, which replicated the MRI and cognitive assessments.

The mean age of participants was 20.44 years and 65% were female. COVID+ status was confirmed through positive reverse transcription polymerase chain reaction (RT-PCR) tests within 12 months of follow-up. Neuropsychological assessments used the Cambridge Neuropsychological Test Automated Battery (CANTAB) to evaluate spatial working memory.

MRI and functional MRI data were acquired using a 3-Tesla scanner, processed, and analyzed for structural and local functional connectivity using eigenvector centrality mapping (ECM) and functional connectivity (FC) metrics. Whole-brain functional connectivity metrics showed no significant differences between COVID+ and control groups, indicating that the observed changes were specific to key brain regions rather than generalized across the entire brain.

Statistical analysis involved the use of pairwise Student's t-tests, Kolmogorov–Smirnov test, linear regression, two-waves mediation analysis, negative binomial regression, and linear regression, all adjusted for covariates.

Results and discussion Significant differences were observed in the two groups regarding the time between assessments, COVID-19 symptoms, and vaccine status. The research identified five localized functional connectivity hubs with significant differences between the two groups, including the right intracalcarine cortex, right lingual gyrus, left frontal orbital cortex, left hippocampus and left amygdala, which is vital for cognitive functions. Only the left hippocampal volume showed a significant reduction in COVID+ participants (p = 0.034), while whole-brain connectivity remained unchanged, reinforcing the localized nature of the brain changes.

The left amygdala mediated the relationship between COVID-19 and spatial working memory "between errors" (p = 0.028), a critical finding that highlights the indirect effect of amygdala connectivity on cognitive function in COVID+ individuals. This mediation analysis underscores the role of specific brain regions in influencing cognitive deficits, as only the indirect effect was statistically significant for spatial working memory errors. The orbitofrontal cortex, involved in sensory integration and cognitive functions, also showed decreased connectivity in COVID+ individuals, supporting previous findings of structural and functional changes in this region during COVID-19.

The study is limited by small sample size, lack of diversity, potential confounding factors due to the long interval between MRI scans, treatment of certain subjects as COVID-negative based on antibody testing beyond the 12-month threshold, and the possibility of non-significant findings in mediation analysis due to these factors.

Conclusion In conclusion, the findings indicate persistent structural and functional alterations in specific brain regions of COVID-19-positive adolescents and young adults, including changes in gray matter volume and localized functional connectivity, which correlate with diminished cognitive function, particularly in working memory.

Further research is necessary to evaluate the longevity and potential reversibility of these brain and cognitive changes post-infection, enhancing our understanding of post-COVID outcomes and informing future interventions and treatments. The longitudinal design of this study, with pre- and post-COVID data, strengthens these findings by allowing direct comparisons over time, offering robust insights into the impact of COVID-19 on adolescent brain development.

Journal reference: COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study. Invernizzi, A. et al., Translational Psychiatry, 14, 402 (2024), DOI: 10.1038/s41398-024-03108-2, www.nature.com/articles/s41398-024-03108-2

[toss-a-coin-to-your-stan-account]

everyone's rightfully talking about jaskier's "get rid of him" and Trauma-Rooted Finger Fidgeting about rience but what about "I'll come find you when rience is dead" "or he'll find me once you are" like. jaskier is absolutely fucking terrified of rience coming for him again and I'm in fucking shambles

[puppyeared]

Why are ppl scared to call it what it is and say we’re still going thru covid on top of seasonal illness. Like. That’s pretty important right. I was watching the news and they were like oh yeah we have an unprecedented number of flu cases “as well as other sicknesses” without actually saying Covid. No announcement abt vaccinations or masking or anything. Also if I hear someone joking abt “war flashbacks” for mentioning covid I fucking hate u

[rearranging-deck-chairs]

so im listening to the potd audio commentary and jodie's talking about covid restrictions and filming flux and how the restrictions were more intense at the start of filming (was that end of 2020/start of 2021?) and she says "by the time we finished, we could hug" and damn they took that opportunity didnt they

[curioscurio]

Got up early (for me), ate a light and healthy breakfast, applied to some jobs, took a long mental health walk with the dogs, gave one of them a bath, and even did some phone calls and messaging regarding my medication and pharmacy problems and managed to sort it out without breaking down!!! And! Showered!! Kicking ASS at mental health today

[i-still-mask-because]

I still mask because:

I don't want any of my disabilities to get worse

I'm still young and I want a long future. I really *do* want to live my life

I'm afraid of the unseen damage that could be done to my body that medical professionals would brush off or minimize

People seem to care less about getting people sick now (less covering mouths when coughing/sneezing, coming to gatherings sick without telling anyone, minimizing flus and vomiting bugs as no big deal, etc). Even if it's not covid, I have a deep fear of sickness and I don't want to catch *anything*.

Being covid-concious is barely a thing in my country

I hope even one person will see me and think about wearing a mask themself

😷

[amurder-ofcrows]

just went through all my blogs to change my age from 20 to 21 (today is my birthday!) and that’s to weird to do lol

[daily-rikukingdomhearts]

Another nanny story 😏🫴

[disasterhimbo]

I’m not sure if anyone’s noticed, but if you’re wondering why I often go days without posting anything recently, it’s the long covid. Sometimes I’m too tired to even use my phone in bed.

Wear a respirator (KN95 or better, N95s tend to seal better but it depends on your face shape).

There’s a 10% chance of long covid every time you get infected, 59% of transmission is asymptomatic, you can get it outside (I did), and this shit sucks ass. Also, there’s gonna be a bird flu pandemic soon too if there isn’t already.

[iero]

You guys ever think about how if you weren't in a certain place at a certain time, in a certain predicament at a certain time you would have never heard one of your favorites bands to this day. Because I do. I think about it all the time.

[snzluv3r]

i actually feel so incredibly uncomfortable and isolated in this space right now and i know that’s silly because of how many people there are just like me who share the same feelings but idk…the fact that people even think this is defensible behavior is making me feel sick

[covid-safer-hotties]

COVID linked to 65% of new onset cognitive impairment, dementia - Published Aug 13, 2024

-Study finds link between COVID-19 and dementia in people 65 and older

-65% of patients tested had new onset cognitive impairment

-Further research is necessary to identify the exact correlation

A new study says there is a link between COVID-19 and the risk of cognitive decline and dementia in older adults.

A study published by the scientific publisher Elsevier indicates that cognitive impairment may be an important condition that comes as a consequence of being infected with COVID-19. The overall proportion of patients identified as having new onset cognitive impairment was 65%.

The study found that patients aged 65 and up, most of whom were hospitalized for COVID-19, had evidence of cognitive impairment, with new onset impairment accounting for over half.

These findings were true even when patients with neurological symptoms in the acute phase of COVID-19 were excluded.

Further research is necessary, according to the study, to clearly identify the exact causes, the role of vaccination in preventing this and potential recovery from it over time. Vaccination against COVID-19 reduces the risk of hospitalization and further complications.

Study Link: www.sciencedirect.com/science/article/abs/pii/S1568163724002666

Lemme know if you can access this study: I'd like to read it

[playingplayer2]

X/Twitter link