#synthese testosteron

[gezondenmooi-net]

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[rolandkaros]

in addition to all of britain's various other crimes their shower water is also making my hair fall out.

[buysomecheese]

Preventing myself from freaking tf out by remembering that even my hormones don’t want to be in my body even my body is trying to prove that it’s Wrong and it’s funny that everything agrees with me except my mom and the government

[weyrleaders]

today i am thinking about sidestep realizing theyre trans in the next game and mortum helping them start transitioning

[catboybiologist]

“As a biologist, the terms biological woman and man don’t make any sense to me” okay then you’re an idiot and a terrible biologist. I swear to god, morons like you only become biologists just so you can hold it over others, when in reality, if biology deniers like you can become biologists, then being one really doesn’t mean much anyway. But this probably just gave an autogynophile like you a boner to read, anyway.

Oh fun! Haven't gotten one of these in a while. Disregarding the fact that you somehow think the qualification for being a biologist entirely hinges on defining womanhood, I do need to ask some clarification. I know I'm feeding the trolls here, but here we go: does your definition of "biological woman" mean:

Sociological woman? Eh, context dependent, I'm not fully out of the closet, but oftentimes, I am and present femme. So let's call that one 50/50.

Psychological woman? Because I am one.

Neurological woman? Because I am one [1].

Physical woman? My soft tissue redistribution is handling that well.

Hormonal woman? My blood tests are within cis female ranges.

Transcriptional woman? As a signalling molecule, the downstream effects of estrogen have broad transcriptional effects, completely changing the profile of gene expression and functional genomics of my cells. [2]

Genetic woman? I mean, see my above point- as far as my genes that are actually active, I have all of the same transcripts being produced, controlling which genes are expressed.

Karyotypic woman? I actually have a few signs pre-HRT that might point to a non-XY chromosome pair, but I haven't had a karyotype. We'll put that down as unknown. And hell, even if its XY, there's plenty of cis women who are karyotypically XY, with suppressed sry or complete androgen insensitivity. Interestingly enough, a completely androgen insesitive woman can go her whole life without knowing- and functionally, is very similar to a trans woman, actually. Fancy that. [3]

Reproductive woman? I can't produce an egg cell, but neither can significant fractions of cis women. Also, this is all gonna change soon, which is fun. [4]

There's also a lot of understudied aspects to the biology of HRT and even pre-HRT that are emerging, largely demonstrating widespread cellular and genetic remodeling of trans individuals undergoing hormone therapy. The field is a bit behind due to constant political pressure to revoke funding, but a lot of the results are extremely exciting in both testosterone and estrogen hormone therapies. I'm sure that, as a self professed biology As someone who presumably has a lot of expertise in biology, I'm assuming that you're aware of all of this cutting edge research, and are keeping up with modern papers, including but not limited to these cool findings:

Trans men on HRT exhibit significant genetic and transcriptional changes that make them biochemically male. [5][6]. It's a good hypothesis that the same happens with estrogen treatment, but those studies don't exist yet- I'm sure you're reserving judgment until more publications exist, of course.

Trans men on HRT develop male cell types and tissues. [7]

Trans women experience muscular and blood cell changes that align with cis women moreso than cis men [8]

And many, many more! This is an exciting, underserved, and groundbreaking field of research, and I'm sure you're keeping up with the latest in scientific journals about it.

I'm sure, of course, that you understand that it becomes impossible to draw a distinct line anywhere in here, and that words like "woman" are shorthand for the myriad of traits that invisibly synthesize in our mind and in society to represent a concept? I'm sure you understand that science is fundamentally descriptive, not prescriptive? I'm sure that you understand that these findings, while really cool and interesting, actually don't mean jack shit about what the word "woman" means or not?

As someone who is the ultimate decider in what a biologist is, I'm sure you know that bioessentiallism is a childish mindset that completely ignores and disregards the constantly changing, dynamic nature of biological systems, something that extends well beyond biological sex and its relation to gender.

I'm sure that also, that you understand that beyond just this, that the role of science in society is to advise how to achieve our moral principles, not create moral principles in themselves. And I'm sure that understanding means you know that trans affirming healthcare and supportive societal treatment leads to reduced mortality and increased happiness for everyone, right?

So great to talk to someone who is surely a scientist on this. You are a biologist, if you're talking like this, I assume? I assume you're not going to spit complete misreadings of scientific language from the background sections of these papers that only reveal you've never read a scientific paper in your life if you're thinking this way? I assume you have experience interpreting data like this?

Also, imagining my genitalia while writing this? Ew. Please stop projecting your fetishes into my inbox.

Works cited:

Kurth F, Gaser C, Sánchez FJ, Luders E. Brain Sex in Transgender Women Is Shifted towards Gender Identity. J Clin Med. 2022 Mar 13;11(6):1582. doi: 10.3390/jcm11061582. PMID: 35329908; PMCID: PMC8955456.

Fuentes N, Silveyra P. Estrogen receptor signaling mechanisms. Adv Protein Chem Struct Biol. 2019;116:135-170. doi: 10.1016/bs.apcsb.2019.01.001. Epub 2019 Feb 4. PMID: 31036290; PMCID: PMC6533072.

Gottlieb B, Trifiro MA. Androgen Insensitivity Syndrome. 1999 Mar 24 [Updated 2017 May 11]. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1429/

Murakami, K., Hamazaki, N., Hamada, N. et al. Generation of functional oocytes from male mice in vitro. Nature 615, 900–906 (2023). https://doi.org/10.1038/s41586-023-05834-x

Pallotti F, Senofonte G, Konstantinidou F, Di Chiano S, Faja F, Rizzo F, Cargnelutti F, Krausz C, Paoli D, Lenzi A, Stuppia L, Gatta V, Lombardo F. Epigenetic Effects of Gender-Affirming Hormone Treatment: A Pilot Study of the ESR2 Promoter's Methylation in AFAB People. Biomedicines. 2022 Feb 16;10(2):459. doi: 10.3390/biomedicines10020459. PMID: 35203670; PMCID: PMC8962414.

Florian Raths, Mehran Karimzadeh, Nathan Ing, Andrew Martinez, Yoona Yang, Ying Qu, Tian-Yu Lee, Brianna Mulligan, Suzanne Devkota, Wayne T. Tilley, Theresa E. Hickey, Bo Wang, Armando E. Giuliano, Shikha Bose, Hani Goodarzi, Edward C. Ray, Xiaojiang Cui, Simon R.V. Knott, The molecular consequences of androgen activity in the human breast, Cell Genomics, Volume 3, Issue 3, 2023, 100272, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100272. (https://www.sciencedirect.com/science/article/pii/S2666979X23000320)

Xu R, Diamond DA, Borer JG, Estrada C, Yu R, Anderson WJ, Vargas SO. Prostatic metaplasia of the vagina in transmasculine individuals. World J Urol. 2022 Mar;40(3):849-855. doi: 10.1007/s00345-021-03907-y. Epub 2022 Jan 16. PMID: 35034167.

Harper J, O'Donnell E, Sorouri Khorashad B, McDermott H, Witcomb GL. How does hormone transition in transgender women change body composition, muscle strength and haemoglobin? Systematic review with a focus on the implications for sport participation. Br J Sports Med. 2021 Aug;55(15):865-872. doi: 10.1136/bjsports-2020-103106. Epub 2021 Mar 1. PMID: 33648944; PMCID: PMC8311086.

[lillybean730]

drawing herlock sholmes tits to relax :]

[jellyfemmedyke]

You know when it comes to trans or hrt stuff, I've never seen anyone mention Percy Lavon Julian, who was a super smart chemist. I saw a drunk history about him a long time ago and I've always thought this guy was so cool

Percy Lavon Julian (April 11, 1899 – April 19, 1975) was an American research chemist and a pioneer in the chemical synthesis of medicinal drugs from plants.[1] He was the first to synthesize the natural product physostigmine and was a pioneer in the industrial large-scale chemical synthesis of the human hormones progesterone and testosterone from plant sterols such as stigmasterol and sitosterol. His work laid the foundation for the steroid drug industry's production of cortisone, other corticosteroids, and birth control pills.[2][3][4] From Wikipedia

This guy found out you can synthesize testosterone and progesterone out of soy beans and we never talk about him. He fought really hard to become a chemist, even having to leave the country to finish his schooling and get a PHD he's also played by Jordan Peele in the video

[drdemonprince]

I was afraid of using drugs for the majority of my life, and before testosterone was too physically sensitive to ever properly achieve an altered state on any substance, even alcohol.

In the last few years I have experimented a bit more with drugs. And I can't really determine whether it has been "good" for me, because how would I even evaluate that? It hasn't made me more productive, but I don't care about improving my productivity. It hasn't made me happier, but I think pursuing happiness is a foolish and unachievable goal. It has occasionally given me the illusion of a new insight, but I've always been highly cerebral and inwardly focused so at the most it's only hasted me making some realization I was bound to discover anyway.

But using substances has given me new aspects of inner experience, and it has been interesting. I am a writer first and foremost and my (entirely self-determined) purpose in life is to find things interesting, to observe and experience things, and make meaning of them, and to synthesize those influences into the art that I make. And I do consider it art, not science, not scholarship, but a form of creative expression and exploration. I never forget that the word "essay" means only "to attempt." I am a trier, and explorer, ultimately.

And to that end, I can view my life as worthwhile and the decisions that I make as acceptable, regardless of whether they make me a better person or a worse one, and despite my characteristic unhappiness and fault-findingness, because no matter what happens to me or how I feel about it, I can always at least choose to find things interesting. Drug use is one thing that I have found passably interesting and novel, from time to time.

Repeated, heavy, compulsive drug use can lead one into some truly boring lifestyles and places, from what I have observed, and that's somewhat the problem with unrelenting hedonism too: it gets dull. But nothing motivates me quite like being interested, and trying new things, and drugs are just one relatively more recent element of that, for me.

[ideas-4-stories]

Cross Guild romance AU -

Buggy makes his own explosives, which doesn't sound all that important until you sit back and think of the ramifications and knowledge required for that. Buggy is damn good with chemistry, math, physics, and I bet he was the brain to Shanks's brawn on the Oro Jackson; he'd probably have been all over Crocus whenever he could to learn more about anything and everything.

Crocodile and Mihaw don't really put the two together, given that they see Buggy primarily as an idiot and coward. It's when an epidemic spreads on the island that some odd things click into place-

Buggy has forgone the big costume, is in comfy and sturdy clothes. His face is painted minimally, hair tied into a tight bun, bandana on, and he's working side by side with the medical professionals. He's elbows deep in checking vitals, organizing charts, and even synthesizing medications. More members are sick than not, and they go under a near-quarantine lock down to handle the illness. Between working in the medical tents and taking care of his people, Buggy has also had a hand in organizing for resources to be sent and delivered.

Neither Croc nor Hawk had even considered some of the balls Buggy has gotten rolling. They both have very strong immune systems, so they rarely face or think of illness or sickness as something to prepare for or to account for, but this just exploded one day seemingly without warning, and the clown had a plan in motion by eevening.

It's at this point that they begin to wonder if maybe there's something more to their Chairman than they first thought...

((Bonus points, they catch Buggy coming back from a long shift at the medtent, sent off by the other's to get some rest, so he's just at that sweet spot of tired enough to lose filter. They ask about the medicines, and Buggy goes on a mini infodump about chemicals, hormones, enzymes, antioxidants and antibiotics, mentions that he and a few others already have a few batches baking, and sleepily chuckles about how "the simpler ones seem to work well so far, thank goodness. I was worried... *yawn* that I'd have to dip into my supplies for my testosterone... *falls asleep at the table*.

Croc just becomes the Spiderman meme of "TRANS???" when Buggy wakes up))

I LOVE this is an understatement, this is so good!!! I love Competent!Buggy so much!!! Why can't the clown be a fucking genius while being clown-failure babygirl he is?

Buggy having a plan by evening is because he has so much anxiety, I mean, look at the poor clown! It's always the things that he didn't think of that happens that gets him in trouble. But this, he can do this. I also love the headcanon, that Buggy learn a lot of things from Crocus, so he has this in the bag!

It would be funny if Buggy could be fine in a really bad pandemics, but the flu and whatever the happened near Laugh-Tale is his biggest sickness problems. What am I saying, back to this cool ask!

Buggy being competent because he doesn't want his crew to die or get really ill, not because he needs them to work, but because he wants them healthy and happy. Buggy forgoing the pillow onesie for something better, and not taking that much time on his makeup is so good, that just shows how he priorities his Nakama before himself is so cute! I have a headcanon that Buggy has a least a Field Medic degree or a Nurse one. Mihawk and Crocodile watching at the sidelines is what I see them doing, because like the clown's being competent and they see there's not much they can do in this.

Yes, on Buggy rambling on and on about things he does, I want Buggy to infodump so hard. Like really really hard, Buggy could go on and on about things that interests him for a while.

Buggy is every gender and nothing at all to me, and the spiderman meme with Crocodile is the only one pointing at Buggy while Buggy is confused and sleepy, while Mihawk is just there on the sidelines. Is really funny to me.

[theriverbeyond]

How aware is cam that pal is synthesizing testosterone in her body in between my teeth?

fic link here

HMMM I actually never thought about that when writing, but I would say if Cam doesn't know for sure that Pal is doing it, she would probably assume it is a possibility.

In-universe, I made up the idea that trans necromancers have something called the "endocrine reflex", where their bodies reflexively attempt to synthesize the correct sex hormone at puberty -- not to the extent of full binary transition, because I don't think non-Lyctor-necromancy allows for such a complete overhaul of ones own physiology (especially without conscious and sustained effort), but it would be noticible to a Lyctor looking in, and without further intentional intervention would result in hormone imbalances that potentially externally have similar results to stuff like PCOS or gynecomastia. maybe more or less extreme depending on the individual.

but back to Cam, I think that this would be a known phenomenon in the Nine Houses, so Cam would probably be able to put together the assumption that when Palamedes is active within her body, his soul may be reflexively attempting to synthesize testosterone. I don't think she would have a problem with it if she did know -- Cam's Whole Issue is that she doesn't consider herself to be her own person, seperate and independent from Palamedes. So like... even though I DO think that Cam deserves a little T, as a treat, I think it's impossible to seperate any personal gender fuckery she might have going on with her fullbody devotion to being Palamedes'.

[eldritch-bf]

Herbert West identity related headcanons:

ftm (obviously) gay and demi

if he’s 24 in 1985 then he was born in 1961 oof

I’m also using some info from the novelization as canon so he is Canadian and his parents died in a chemical fire in the house when he was 12-13

was forced to take ballet when be was 5-10 (something Jeffry Combs joked about in the commentary from Bride)

his parents were neglectful of him and didn’t really care about him wanting to have short hair or boy clothes plus they chalked it up to his presumably undiagnosed autism

realized he felt weird about the older boy in the foster home (13-18) but didn’t really understand it; mostly he is jealous when girls take away the boy’s attention; closest friend he ever had as they were alone together but Herbert knew he could never act on it so he kept those feelings to himself

he wants sex but only from someone he’s emotionally connected with which itself is rare and at the same time intellectually he considers sex to be debasing, while also being curious about the sensation and knowing the benefits of the chemicals produced during orgasm

this is coupled with the fact that at least before starting T any thought of sex or masturbation made him extremely dysphoric and repulsed so his whole relationship with sex is very complicated

he is deeply repulsed by femininity bc it reminds him of his childhood spend as his agab and the stupid gender norms his parents thrust upon him including dismissing him being a scientist just because he had the wrong parts

he is canonically annoyed by pretty much all sounds and I suspect higher pitched sounds including women’s voices are worse; lower register sounds like thunder and men’s voices can be calming to him

upon moving from Canada to the U.S. as a student at NYU he used his new name on everything and making a clean break from his old identity was a big reason why he picked a different country to study in

hated NYU and the only good thing was it was easy to synthesize testosterone

T made him so fucking horny and also eviscerated his dysphoria; man was cranking it fucking constantly for a year straight and did some of his best work before moving to Switzerland for 3 years

Dr Gruber immediately figured out what his deal was but didn’t say anything and just treated him normal and for that Herbert was extremely devoted to him; Dr Gruber also did his top surgery in Switzerland despite having never done such an operation before

Dr Gruber was the one and only member of his support system the only person who knew everything about him and understood him and accepted him, losing him was a devastating blow and Herbert decided he would keep himself closed off

Also Dr Gruber didn’t have anyone either and adored Herbert and according to the book fucking left Herbert his money when he died which paid for his tuition and moving costs etc

if I didn’t genuinely like the father/son dynamic they have, I would absolutely say he was fucking that old man

So he was cool and clipped to Dan when he first met him and when he moved in trying to keep Dan at arm’s length away but he saw how smart and hardworking Dan was and he knew how difficult it was to conduct this research alone and he desperately wanted the company

and Dan reminded him a lot of the first boy he ever had a crush on and it would give him a certain satisfaction to vicariously have his first crush through Dan yet also knowing that Dan is way better than the idiot teen boy he was in the foster home with who never gave him the time of day; he’s also pleased with the idea of dragging Dan (normal, supposedly heterosexual, law-abiding) down with him; he’s pulling the brightest kindest handsomest hardest working med student out of Miskatonic into his orbit and making Dan’s life revolve around him

literally “look at the bad bitch I pulled by being a little freak” absolute nightmare Herbert West takes personal pleasure in ruining sweaterboy Daniel Cain’s life

the chaos of everything they do is so much more important that when Dan finds out Herbert is trans and gay it doesn’t even phase him.

(Daniel Cain is bisexual and basically decided it was just easier to be pretend to be straight and get a girlfriend so he ignored his feelings for men. But now with Herbert he doesn’t have to.)

he is completely shocked by sex with Dan however despite knowing that Dan is experienced he was not prepared nor was Dan prepared for how awkward yet demanding the virginal Herbert West would be, yelling at him one moment before becoming cock stupid the next

[pseudohades]

[Barduil Western AU] ➻ in the lake

➻ not fem!ver or genderbent. this is a trans man drawn by a transmasc artist. uncensored on my bsky & ao3. version without filters & some AU info below the cut

(not pictured: the lake) ➻ Thranduil is a trans man in this AU. ➻ Thranduil draws portraits for wanted posters based on witness descriptions. Bard is one such outlaw. ➻ Thranduil is basically smitten by his drawing of Bard. when they meet through a series of mishaps, Thranduil discovers to his dismay that Bard is even more attractive in person, and Thranduil's rendition didn't do him justice. ➻ meanwhile, he's basically been accidentally kidnapped and now they're roughing it in the Rockies together because Bard can't just bring him back to where he's supposed to be without getting swarmed by lawmen. the lines between captive and companion get a little blurred. ➻ ...and there was only one horse. her name is Duchess. she's a Percheron. (I'm sorry horse nerds, I know riding double is bad for the horse, I'm bullshitting this bit. they aren't traveling that far that fast or very often, so it's not constant strain on her. please forgive me.) ➻ Oropher and Thranduil's Fiancé aren't so willing to let him go. they've been trying to track him down since he fled Boston a few years back. Thranduil would rather die than be caught by them; now it's not just Bard who's on the run. ➻ the story mostly takes place in Colorado during the 1880s, which is well before testosterone was isolated and synthesized, but I couldn't resist giving him just a little bit of a tdick, so again you can find that uncensored on my bsky & ao3. ➻ I will probably talk more about this AU and draw for it in the future over on my SFW blog, @plutolichen ➻ Thranduil's moles that I've just decided he has are so important to me.

[homokommari]

Have you ever done anything with Bruce taking HRT? I love your take on him and Clark i eat it up every time

Also happy pride <3

hmm... i haven't drawn him taking t, just assume he does off screen. i dont really just have anything to draw abt it i guess..? he took injections for many years but in his 30's switched to gel. is that anything? is anything anything? happy pride! :)

i also haven't drawn bruce administering kryptonian testosterone equivelent that he synthesized himself to clark. but i think about it a lot. the homoeroticism. penetrating. all that.

[edgebug]

i feel like we've collectively hallucinated a version of breaking bad that has very little to do with the actual show. it is a truth universally acknowledged that jesse pinkman is a trans man, and walter white is not only synthesizing testosterone for him, but also paying for his top surgery. by selling meth

[freytful]

. Unironically i (chemistry student) might be closer to being able to synthesize testosterone with my own hands than i am to actually getting it legally LOL

[ghostzzy]

i’ve been attempting to synthesize my thoughts and concerns about going on testosterone for about half an hour now and i’m making very little progress.