#mitochondrial

[ub-sessed]

trick! 🧶🧶🧶

Oh man, you are the person who has knitted my nerdiest knitting pattern of all! Nothing can out-nerd the DNA sweater with painstakingly recharted DNA! I'll see what I can find...

You're getting the Mitochondrial socks by Dana Gervais! (Hope you're not tired of DNA cables.) The ribbing at the top of these socks is a nice touch.

[pixelcoin]

Day 15 biological love

Mitochondrial belongs to Icy_Commercial3517 on reddit

Happy bday my little overgrown goat clone

[sciencesolutions]

[impact-newswire]

BPGbio Appoints Esteemed Cancer Researcher Dr. Dipanjan Chowdhury to Scientific Advisory Board

#AI #biopharma #therapeutics #mitochondrial #proteinhomeostasis #oncology #neurology #raredisease #drugdiscovery  @BPGbio

[fqtoxicity]

New Post has been published on My Quin Story

New Post has been published on https://www.myquinstory.info/pentadecanoic-acid-c15-for-mitochondrial-health/

Pentadecanoic Acid (C15) for Mitochondrial Health

I am starting to get good reports from people suffering from FQAD about Fatty15.

What is Fatty 15 you ask? 

Fatty15 is technically pentadecanoic acid, commonly referred to as C15 or Fatty15. C15:0 is the first essential fatty acid to be discovered since the omegas—over 90 years ago. It is an odd-chain saturated fatty acid that has been garnering attention in the health and wellness communities for its potential benefits, particularly in relation to mitochondrial health. Mitochondria, the powerhouses of cells, play a crucial role in energy production and overall cellular health and are often damaged in various ways from Fluoroquinolones leading to a host of problems. From all preliminary indications Fatty15 appears to have a significant positive impact on mitochondria.

For my readers who like to geek out on the science, C15:0 is a sturdy, odd-chain, saturated fatty acid that integrates itself into cell membranes to fortify and strengthen them, giving them better protection against oxidative stress and cellular degradation than omega-3 fatty acids. Studies show that C15:0 supplementation improved cellular stability by 80% (1).

Mitochondrial dysfunction/disease is a key hallmark of Fluoroquinolone toxicity and in turn that drives, or contributes, to the onset of chronic diseases (FQAD). C15:0 increases mitochondrial function by up to 45%, keeping our cells active and ensuring they’re able to carry out cellular processes as they should. The mitochondria produce ATP, your cell’s energy currency. In studies, C15:0 was able to increase ATP by up to 350%. A pretty impressive feat!

C15:0 Long-Term Benefits  

C15:0 (Fatty15) has been shown in peer-reviewed studies to: 

Strengthen cellular membranes, making them more resilient against age-related breakdown. Fatty15 contains pure C15:0, which is a sturdy fatty acid that imbeds into the lipid bilayer of membranes to protect cells against lipid peroxidation. Fatty15 has been shown to improve cellular stability by 80%.

Repair mitochondrial function and restore cellular energy. Fatty15 has been shown to improve mitochondrial function by 45%. These benefits result in increased ATP energy production and reduced reactive oxygen species (ROS). 

Naturally activates AMPK to support glucose control. Fatty15 activates AMPK, which supports our long-term health and is a core component of the human longevity pathway.

Lowers multiple pro-inflammatory cytokines to balance immune responses. Fatty15 lowers key cytokines, including IL-6, MCP-1 and TNF-alpha, which are responsible for aging-related breakdown.

Naturally activates PPAR-alpha and delta receptors, which regulate our metabolism and immunity. Additionally, PPAR-alpha activators have been proposed to support brain health, while PPAR-delta activators can be heart protective.

C15:0 is also helpful in assisting with clearing damaged cells. Some people FQAD suffer from an accumulation of damaged cells. C15:0 activates AMPK and inhibits mTOR, which are important mechanisms to slowing cellular senescence and clearing damaged cells. AMPK is also essential in regulatory processes, like glucose uptake (2).

C15:0 (Fatty15) near-term benefits:

Near-term roles of PPARs. Many of fatty15’s near-term benefits are due to fatty15’s role as a natural activator of two key receptors, called PPARs (pronounced pee-pars) alpha and delta, that are present throughout our body – including our brain. In addition to these long-term benefits, PPARs help to regulate our mood, stress, sleep patterns, energy, and hunger. 

Near-term roles of PDC. Our bodies use C15:0 to naturally make a second molecule, called pentadecanoylcarnitine (what we refer to as PDC). PDC is the second-ever discovered full-acting endocannabinoid and has been shown to:

Activate CB1 and CB2 receptors as an endocannabinoid that can help to improve joint comfort, mood, and sleep.

Activate 5-HT1A and 5-HT1B receptors to reduce stress.

Inhibit histamine H1 and H2 receptors to calm immune responses.

Unfortunately a person can’t get C15:0 by just eating foods. The short of it is that while C15:0 is available in trace levels in food, especially whole fat dairy products, food-based C15:0 is tied up in complex lipids called triacylglycerides, which we cannot absorb.  If you attempt to get large amounts of C15:0 from dairy you would have to consume an outrageous amount of dairy fats that would give you a much higher levels of ‘bad’ even-chain saturated fats (like, C16:0) and the negative effects would greatly outweigh the positives. 

Another positive is that it also appears that for some people who can tolerate Omega-3’s, C15:0 seems to well tolerated and C15:0 is dosed in one small capsule per day and delivers the same benefits as Omega 3’s plus much more. 

Side effects: Since C15:0 was discovered as an essential fatty acid in 2020 and introduced to the public in 2021, over 17,000 customers have taken fatty15 with very few side effects. A few minor side effects have been reported in less than 0.1% of customers: constipation, diarrhea or  headache.  Due to confounding factors it cannot be confirmed confirm that these side effects are directly attributable to C15:0 supplementation.  One floxed person reported a minor headache that went away after a few days, and another reported a transient case of nausea. 

Conclusion

Right now, Fatty15 (C15:0) is only available to purchase from the company who discovered it, and that is a the Fatty15 website. They do not sell on Amazon or in retail stores.  Keep in mind that Fatty15 is not a magic cure all.  It is however a substance that shows promise in the ability to heal heal or support injured mitochondria, in addition to providing other benefits.  My opinion is that it might benefit those who are suffering from mitochondrial issues stemming from fluoroquinolone toxicity and I have had reports of improved energy and sleep. 

One drawback is that like many new products, it is expensive, and it needs to be taken for a while to achieve full benefits.  I have secured a 20% discount for those who want to try it by just clicking on the Fatty15 logo below.  You will then be taken to the website for Fatty15.   As usual, any benefits received for the referral link will be passed-on to other floxed people. 

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[walksotheycanrun]

Do you ever feel like there is constantly more wrong with you? Like you have one diagnosis and then suddenly all the co morbidities fall out of their hiding places like they have forgotten how to sneak

[smoov-criminal]

happy disability pride month to those with conditions no one talks about, online or in general:

multiple sclerosis (me lol)

marfans

cerebral palsy

bells palsy

hidradenitis suppurativa

cauda equina syndrome

mixed connective tissue disorder

hyperadrenergic pots

non hypermobile eds types

stickler syndrome

mitochondrial disease

cystic fibrosis

sickle cell disease

myasthenia gravis

post-cholecystectomy syndrome

SWAN (syndromes without a name)

...just to name a few. i see you and you deserve awareness and understanding.

this list is non exhaustive, rb with other conditions you want to see represented!!

[ID: a post banner with dark red background and medium grey bolded text in the center. it reads “This post is about physical disabilities, do not derail.” On each side there is the dynamic disability icon, a gray symbol of person in manual wheelchair leaning forward with arms bent behind them mid-push. /end ID]

[briarpatch-kids]

Trying to explain my level of functioning to new people is hard. Like yes, I can cook from scratch a couple nights a week. No, I cannot stand, dress myself, or bathe independently.

[mindblowingscience]

Scraps of DNA discarded by our neurons' power units are being absorbed into our nuclear genome far more frequently than assumed, potentially putting our brains at greater risk of developing life-threatening conditions. An investigation by a team of researchers led by Columbia University in the US has found individuals with higher numbers of nuclear mitochondrial insertions – or NUMTs (pronounced new-mites) – in their brain cells are more likely to die earlier than those with fewer DNA transfers.

Continue Reading.

[books-books-smolderinglooks]

"Don't blame me, love made me crazy If it doesn't, you ain't doin' it right" ❤️❤️

[stagegoose]

shout out to those of us chronically ill people who have stacks of rare diagnoses that took years or decades to dx. Shout out. to those of us in those categories who had earlier diagnoses questioned because of our other, at this point undiagnosed, rare illnesses.

To have a doctor look at something very concrete and telling of a certain diagnosis (for me, it was a muscle biopsy that showed a very obvious mitochondrial cytopathy) and go 'nah i don't think its actually this thing we have evidence of' because you also have another completely unrelated rare illness is gross and inexcusable.

If you are in this situation, i pray that things prevail for you. Remember that you know your body far better than any medical professional ever will, and that no matter what they say, you're not crazy for having inexplicable symptoms.

to deny the idea that someone can be doubly sick with three or more different rare illnesses when we know so little about genetics and all the different ways the human body can screw itself over is extremely and without a doubt idiotic. we all deserve better.

[willowreader]

Excellent article from a scientist who does great research and has her own lab.

[enbycrip]

If I was one of the people in Cheddar who turned out to share mitochondrial DNA with Cheddar Man, I would be *forced* to hang around the local museum referring to him as “Nunkie Cheese” until the long-suffering curator tried to ban me 🧀

[etiragram]

on the plane back from an emotionally grueling week with my family filled with renewed determination not to be an Asian parent. I'm going to yeet my child when they're 18 like I'm white

[banana-pancake5]

Meet the artist!

Hi, my name, here on tumblr, is Moo or M3B! If you would like to know more about myself than hop on under the cut; I’ve stored a couple of facts down there :D

I am a Christian writer and artist, and I’m attempting animation as well! I have lots of shows that I’m very into, but the main ones are TMNT, Snow White with the Red Hair, Project 863, and Gravity Falls (other shows/movies include Haikyu!!, ATLA, Moonknight, Marvel, Studio Ghibli, Steven Universe, over the garden wall, and many more).

The reason my Sona is wearing a Zebra onesie is because the Zebra is the official symbol for Rare Diseases. I have Mitochondrial Disease (I refer to it as Mito), which has effected my life in many ways, though now I’m practically fine which is a wonderful blessing from God, I absolutely love talking about it and will gladly share some of my experiences with anyone who wants to hear! The safety pins on the Onesie are also there because of my experience with Mito, though it’s kind of a long story so I won’t write it all out here. ^-^

I love reading people’s rambles, so if you ever would like to talk about a show, movie, or literally anything, regardless if I’ve heard of it, I’d love to hear in an ask! My asks are also open if you just wanna stop by and say Hi :D

Some fun facts:

- I have three cats, Loki, Sylvie, and Suki <3

- I am 5’ exactly >:D

- my favorite bands are Madilyn Mei and Twenty One Pilots

- besides drawing and writing I also love to cook, bake, and crochet

- I am an ENTP

- I love learning about Psychology :D

- I use all caps and emoticons quite often

- I’m always open to drawing and writing requests, HOWEVER! there’s no promises that I’ll be able to finish it in a decent time frame or at all

———

I would also like to mention some awesome people I’ve met on this website that you should definitely give a follow:

@bowandbrush @ferniforest @exhaustedwriterartist @jadetheblueartist @peoplepersonoaktree @crowsandturtlesandbatsohmy @cookiedoesart64 @allyheart707 (along with all my other mutuals that I don’t have time to tag!!)

[lenbryant]

Show us your talking snake, and then we’ll show you the talking donkey.