#medical drugs

[psychologeek]

So i had a panic attack today

I think

I'm burning myself,

And it shows

I had pain in my arms today

In it just won't stop

(i was never good at

Picking up cues)

I took a pill today

(safely, prescriptioned by the doctor)

I took care of myself

(why does it feel like failure?)

[icarusinfreefall]

reminder that adhd medication isn't a luxury or preference, but a lifesaving medication. a 10 year long study in the usa showed that, when properly medicated, the rate of car crashes people with adhd get into goes down significantly--men's rate drops by 38%, and women's by 42%. the med shortage, denial of meds by doctors, rising prices, and the "war on drugs" has killed--with such a car dependent society, not driving frequently isn't an option, which means we need better healthcare and need it now.

https://shorturl.at/8VD8B

edit because i forgot to explain: short link is to an article by the washington post, it should be free to read

[ahhvernin]

In case you missed it. Much of Americas medical equipment, raw materials, laboratory equipment and drugs come from overseas.

Remember how hospitals, doctor offices and labs didn't have PPE for COVID? Do you remember how it was because alot of the factories that made things like GLOVES, for examination and medical procedures like surgery,were shut down? :D Remember that? Remember how the US could not keep up with their own country's glove demands?!

This country is one of the largest importers, even the things we make in this country uses components sourced from over seas.

So yeah, even your MADE IN THE USA products are ALSO going to increase in price.

[demoniccrowz]

Had to set my alarm for two am so I could do drugs

[reasonsforhope]

"The Biden Administration last week [early December, 2023] announced it would be seizing patents for drugs and drug manufacturing procedures developed using government money.

A draft of the new law, seen by Reuters, said that the government will consider various factors including whether a medical situation is leading to increased prices of the drug at any given time, or whether only a small section of Americans can afford it.

The new executive order is the first exercise in what is called “march-in-rights” which allows relevant government agencies to redistribute patents if they were generated under government funding. The NIH has long maintained march-in-rights, but previous directors have been unwilling to use them, fearing consequences.

“We’ll make it clear that when drug companies won’t sell taxpayer funded drugs at reasonable prices, we will be prepared to allow other companies to provide those drugs for less,” White House adviser Lael Brainard said on a press call.

But just how much taxpayer money is going toward funding drugs? A research paper from the Insitute for New Economic Thought showed that “NIH funding contributed to research associated with every new drug approved from 2010-2019, totaling $230 billion.”

The authors of the paper continue, writing “NIH funding also produced 22 thousand patents, which provided marketing exclusivity for 27 (8.6%) of the drugs approved [between] 2010-2019.”

How we do drug discovery and production in America has a number of fundamental flaws that have created problems in the health service industry.

It costs billions of dollars and sometimes as many as 5 to 10 years to bring a drug to market in the US, which means that only companies with massive financial muscle can do so with any regularity, and that smaller, more innovative companies can’t compete with these pharma giants.

This also means that if a company can’t recoup that loss, a single failed drug can result in massive disruptions to business. To protect themselves, pharmaceutical companies establish piles of patents on drugs and drug manufacturing procedures. Especially if the drug in question treats a rare or obscure disease, these patents essentially ensure the company has monoselective pricing regimes.

However, if a company can convince the NIH that a particular drug should be considered a public health priority, they can be almost entirely funded by the government, as the research paper showed.

Some market participants, in this case the famous billionaire investor Mark Cuban, have attempted to remedy the issue of drug costs in America by manufacturing generic versions of patented drugs sold for common diseases."

-via Good News Network, December 11, 2023

[violent138]

Thinking of Bruce downing like a sizable amount of pain meds due to tolerance and abnormal levels of pain so he can still function and because he's normally so quiet and now he's buzzed quiet there's no outwardly apparent difference unless you're Alfred or one of his kids or Clark. And while Bruce's favourite thing to do in this state is attend WE board meetings, he occasionally has to head to the Watchtower.

Emergencies sober him up fast, but the second a need for coherency ends he lapses back to mellow. Nobody notices that he's been nodding continuously because Clark keeps subtly coughing or lightly kicking his chair.

Works perfectly until Clark kicks it out and Bruce goes down like a stringless puppet.

[s4dpngs]

[funkle420]

Turbo Granny blunt rotation WIP

[kaionyx]

Not to brag but, I’m an official nurse as of today. So that means, I legally have the knowledge to know what drugs to use to make it easier for me to throw you in my back seat to take home with me. But that not all of course, I know your body better than you do.

I can pick apart and coax things out of your little body you never thought possible, all while abusing and molding your holes with my cock until I get my fill and fix you back up for when I decide to break you again. Do with that what you will.

[reality-detective]

Millions of children have been prescribed an asthma drug that causes suicidal thoughts, hallucinations, and other devastating psychiatric conditions.

Montelukast, marketed as Singulair, directly targets cells in the brain responsible for mood regulation, decision-making, impulse control, attention, and sleep—wreaking havoc on young minds.

The most enraging part? This has been known since 2008, yet nothing was done to protect children.

This video from 2008 reveals the FDA did nothing for 16 years. 🤔

[kizzer55555]

Welcome to the Restraint! (Restaurant)

Imagine Danny runs to Gotham and starts squatting in an abandoned old building in Crime Alley. Slowly putting some ecto into the place to claim it as his haunt (while recovering from the sudden loss of his old one). And he does the normal stuff to survive. Finds some odd jobs, often as a messenger, and is just surviving. Another thing he does is make his own food. It’s cheaper than takeout and he’s gotten pretty good at cooking (out of necessity instead of eating sentient hotdogs). Then he ends up accidentally taking in some street kids. Or more like they follow him home. He can’t just turn them away so he makes a meal for them and lets them stay the night then sends them on their way. And then it happens again. And again. And ok, so maybe he saved a girl from getting molested. And that older guy from getting his only good blanket stolen. And sure, maybe letting that poor pizza delivery guy rant was unnecessary but he looked like he was having a bad day ok? Pretty sure that kid with the scar is a meta too but…he needed a place to stay a few nights alright? It’s not like any of them stay permanently. Danny’s started picking up a few more odd jobs to pay for all the extra food he’s had to buy. Always keeping his place stocked. At least he doesn’t have to pay for water and a fridge, he just makes some ice (or melts it). Sure the water is cold, but it’s probbaly the cleanest water in Gotham. And then some of the people start paying. Like…actually paying in exchange for food. Not sure if it’s because of guilt or pity but Danny won’t look a gift horse in the mouth. And with all the money, he hasn’t had to take as many dangerous jobs. Soon, his little abandoned apartment became what’s essentially the closest thing to a legitimate restaurant in Crime Alley.

It didn’t look normal. The chairs and tables were more like old couches and stools pulled up to coffee tables and cabinets turned on their side. Although with the bulling becoming more like Danny’s haunt, the walls naturally started repairing themselves so at least it didn’t look like it was gonna collapse anymore. And ok…so Danny might have rescued a few feral kids who…weirdly have gold eyes. And possibly stopped a meta trafficking ring on accident. And look, these people didn’t have anywhere to go! And the apartment did have empty rooms. It was already known as a place someone could crash for the night (last winter the entire place was cramped with people. Danny had to break up multiple fights but they usually calmed down when he got there.)

One benefit from controlling a haunt is controlling the temperature inside so it was one of the only buildings with ‘heat’. But back to his…strays. So yeah…most didn’t seem like they could rejoin society…so he let them stay. And…they kind of became employees? Impromptu bodyguards? (Some of the golden eyed people almost felt like he was rangling feral ghosts again.) they came in all ages. A few kids, lots of teens, and a few adults. Same with the metas he rescued. They mostly helped deliver food to costumers. They even got a phone line working and could take orders. (Although the new…employees…also got more protective whenever a fight broke out.) With all the extra money he’s been getting he was even able to afford some medical supplies. A lot of his customers(?) came in injured and he tried his best to patch them up but now he could do more than tie some ripped clothing around the wound and use ice to numb it. He’s got bandages. And pain killers. Plus other medical stuff. He can even give someone stickers now! All that experience as an injured vigilante was paying off. Even Villains and goons start attending this place. The place was unofficially designated as one of the Alley’s ‘safe zones’ where no fighting takes place inside (the body guards make sure of it.) the metas and Talons are getting an identity for themselves, the street kids even get a job and a hideout, random people can go there for help or to pass messages, this place provides food, shelter, and medical care. No one wants it going down.

So yeah, welcome to the restaurant!

(I’m debating whether I want this to be the weirdest restaurant/safe place/truce area in the alley, or whether I want Danny to accidentally become a crime lord. Possibly both.)

Also, this place is called the Restraint because I keep misspelling Restaurant and I think Danny would do the same so the name stuck. (Or one of the kids spelled it when making a sign or passing around messages to spread the word of this safe place.)

So anyways, to add some angst, after Danny adopts a bunch of crime alley kids/villains they find out about Danny’s powers and that he’s a ghost, only they don’t know about Halfas so they think Danny is fully dead and this super kind guy who has been the only person to ever treat them like people…died. He died likely a long time ago and there’s nothing any of them can do to change that.

(And if the GIW dare to come into the alley, they better be prepared for the entire place to turn on them.)

[loonybun]

hi whump community let me tell you about a drug called datura!! because boy is it a doozy.

datura is a deliriant, which means it is a hallucinogenic drug capable of causing serious and often terrifying delusions and hallucinations that are literally indistinguishable from reality in the user’s mind.

It is poisonous and part of the nightshade family, and the dosage used to get high off of it is actually very close to the lethal dose. it is also not only entirely legal in most places but also very accessible. it’s grown as a house plant, actually. most people who trip off of it only do it once because of how awful of an experience it is. also trips last like a long time (anywhere from 12 hours to 3 days if i remember correctly?)

the hallucinations that come with this drug are incredibly horrifying, making it literal nightmare fuel. also the more long term effects from it can include permanent psychosis and lingering delusions. fun stuff.

common hallucination experiences from this drug include the following:

- heavy gore

- seeing corpses

- feeling like you’ve been transported to an alternate dimension (hell)

- seeing people or entities you know (but a little fucked up)

- parasites and bugs

- feeling as though your organs are falling out of your body

- shadows in the back of your vision

- smoking phantom cigarettes or eating phantom food (phantom in the sense that they aren’t really there)

- torture scenarios

all in all, i think it’s a rlly interesting thing that can definitely be used in whump. like imagine a whumper lacing someone’s tea with that. the whumpee wouldn’t even be aware that something was done to them due to the fact that they physically cannot tell the difference between delusion and reality. real fun stuff. probably need an immortal whumpee though just cuz if someone takes this there’s a high chance of them getting hospitalized.

[soaringsearingphoenix]

there was a small earthquake here just last night

it was hardly more than a single jolt that i could almost be convinced was just the house settling if my heart wasnt racing in the specific way it always does (and only does) when i did legitimately feel the ground move

i had just had time to stand up from my chair tp start heading fora desk to hide under but the shaking stopped and all that adrenaline in my body wanted action but had nowhere to go

i ended up doing all my dishes before i sat down and realized id done so

... so i think i will be researching a revolutionary new treatment for ADHD

[reasonsforhope]

"A large clinical trial in South Africa and Uganda has shown that a twice-yearly injection of a new pre-exposure prophylaxis drug gives young women total protection from HIV infection.

The trial tested whether the six-month injection of lenacapavir would provide better protection against HIV infection than two other drugs, both daily pills. All three medications are pre-exposure prophylaxis (or PrEP) drugs.

Physician-scientist Linda-Gail Bekker, principal investigator for the South African part of the study, tells Nadine Dreyer what makes this breakthough so significant and what to expect next.

Tell us about the trial and what it set out to achieve

The Purpose 1 trial with 5,000 participants took place at three sites in Uganda and 25 sites in South Africa to test the efficacy of lenacapavir and two other drugs.

Lenacapavir (Len LA) is a fusion capside inhibitor. It interferes with the HIV capsid, a protein shell that protects HIV’s genetic material and enzymes needed for replication. It is administered just under the skin, once every six months.

The randomised controlled trial, sponsored by the drug developers Gilead Sciences, tested several things.

The first was whether a six-monthly injection of lenacapavir was safe and would provide better protection against HIV infection as PrEP for women between the ages of 16 and 25 years than Truvada F/TDF, a daily PrEP pill in wide use that has been available for more than a decade.

Secondly, the trial also tested whether Descovy F/TAF, a newer daily pill, was as effective as F/TDF...

The trial had three arms. Young women were randomly assigned to one of the arms in a 2:2:1 ratio (Len LA: F/TAF oral: F/TDF oral) in a double blinded fashion. This means neither the participants nor the researchers knew which treatment participants were receiving until the clinical trial was over.

In eastern and southern Africa, young women are the population who bear the brunt of new HIV infections. They also find a daily PrEP regimen challenging to maintain, for a number of social and structural reasons.

During the randomised phase of the trial none of the 2,134 women who received lenacapavir contracted HIV. There was 100 percent efficiency.

By comparison, 16 of the 1,068 women (or 1.5%) who took Truvada (F/TDF) and 39 of 2,136 (1.8%) who received Descovy (F/TAF) contracted the HIV virus...

What is the significance of these trials?

This breakthrough gives great hope that we have a proven, highly effective prevention tool to protect people from HIV.

There were 1.3 million new HIV infections globally in the past year. Although that’s fewer than the 2 million infections seen in 2010, it is clear that at this rate we are not going to meet the HIV new infection target that UNAIDS set for 2025 (fewer than 500,000 globally) or potentially even the goal to end Aids by 2030...

For young people, the daily decision to take a pill or use a condom or take a pill at the time of sexual intercourse can be very challenging.

HIV scientists and activists hope that young people may find that having to make this “prevention decision” only twice a year may reduce unpredictability and barriers.

For a young woman who struggles to get to an appointment at a clinic in a town or who can’t keep pills without facing stigma or violence, an injection just twice a year is the option that could keep her free of HIV.

What happens now?

The plan is that the Purpose 1 trial will go on but now in an “open label” phase. This means that study participants will be “unblinded”: they will be told whether they have been in the “injectable” or oral TDF or oral TAF groups.

They will be offered the choice of PrEP they would prefer as the trial continues.

A sister trial is also under way: Purpose 2 is being conducted in a number of regions including some sites in Africa among cisgender men, and transgender and nonbinary people who have sex with men.

It’s important to conduct trials among different groups because we have seen differences in effectiveness. Whether the sex is anal or vaginal is important and may have an impact on effectiveness.

How long until the drug is rolled out?

We have read in a Gilead Sciences press statement that within the next couple of months [from July 2024] the company will submit the dossier with all the results to a number of country regulators, particularly the Ugandan and South African regulators.

The World Health Organization will also review the data and may issue recommendations.

We hope then that this new drug will be adopted into WHO and country guidelines.

We also hope we may begin to see the drug being tested in more studies to understand better how to incorporate it into real world settings.

Price is a critical factor to ensure access and distribution in the public sector where it is badly needed.

Gilead Sciences has said it will offer licences to companies that make generic drugs, which is another critical way to get prices down.

In an ideal world, governments will be able to purchase this affordably and it will be offered to all who want it and need protection against HIV."

-via The Conversation, July 3, 2024

[discordant-daydreams]

Having a lot of feelings about being disabled and hearing over and over that while you feel like you’re dying your labs don’t show that you’re dying so great news!!! You’re as healthy as can be!!!