#macrophage thoughts

[kingmacrophage]

someone drawing winnie with a big fat tail would heal me i think

[ace-detectiv3]

CaW! flower shop AU but it’s mostly centred around Memory and B

Inspired by that one fic on Ao3 except this AU is focusing on just platonic because my Aroace self is incapable of writing romance + I need more of just silly friends being silly friends

Memory is a florist who just recently opened his flower shop with the help of his friend, Shiro (U-1146 ) and the two of them run the shop together

B (No idea for human version of name ) works at a cafe the opposite of the flower shop with Mast, who owns the cafe

Also the three main RBC (AE3803, AA5100 and NT4201 ) also works there, I couldn’t think of a name for them so go ahead and make them yourself </33

Uhhhhhh basically both of the sillies saw each other and was like “Oh hey I kinda wanna be friends with him ” Idk about others but for this AU I just wanted for the relationship to be platonic or queerplatonic,,,, mostly just platonic though

Memory being an absolute idiot just sending flowers with flower language and B just being “?? Flowers?? Neat I guess ” while Mast was trying to tell him about flower language

Oh yeah this is not really important but the rest of the neutrophil squad runs a restaurant, the KTs run a tattoo shop, and the macrophages work at a maid cafe

Just decided to whip this up quickly as a distraction and to make myself feel better

[lakeeffectbitch]

okay far too many people are emailing me in the late hours of the weekend. I am sorry but I simply do not care about your paper stop talking to meeeeee

[crippleprophet]

let me open by saying I Know How This Sounds (fem whose undergraduate chemistry professor recommended ze take turmeric to cure zyr arthritis, etc) so no hard feelings if you keep scrolling, but hopefully folks who know me know i'm speaking honestly about my experiences, even if those don't end up being the same for other people. so!

2 Tbsp of a common kitchen spice is doing as much or more to manage my ME/CFS as any of my meds or self-medicating drugs

@lakeeffectbitch outlines a way of trying this with a control in their reddit post (link); i just went directly to the one they thought might work so i'll put my experiences & the science/theory behind this under a cut for folks who want to avoid potential placebo effect :)

i'll get more specific about this in the "spoilers" but please be aware, especially folks with diabetes or other blood sugar conditions, that this substance may cause a blood sugar drop. it's less likely at this dose but probably keep a sugary snack on hand just in case

if you experience post-exertional malaise & want to try this but don't have spare money to spend on spices feel free to dm me & i'll see if i can help!

my experience:

i took 2 Tbsp ground sumac mixed with warm water on February 11. i tried taking it with a straw first because that's what my colonoscopy prep had said would make that go down easier but because the sumac particles were so big they didn't want to remain suspended & trying to get them in the straw was difficult, which then made it harder to swallow without, yknow, noticing that you're slurping down sediment

what worked better was getting the powder wet, putting a big clump of it on my tongue, then swallowing it with water like a pill

within about half an hour of taking the sumac it was like my fatigue just faded around me where i stood. it dissolved to the background & when i thought "oh i want to do this" or "i should do that" suddenly i found myself just doing it. i had spent the past week at least bedridden except for the bathroom, & though i took the sumac on a better day, i'd been planning to return to bed with a snack after taking it.

instead, i made myself lunch, and i sat on the couch to eat it. all of this was without taking an edible that day; usually i've gotta take at least 25mg delta 8 + 25mg cbd to even consider sitting on the couch. also, it was storming.

from my write-up the day of: "everything felt very sharp & clear & lucid." i washed the dishes from my lunch. all of these activities were about 2 hours, & at that point i emphatically needed a nap. waking up felt like after taking a muscle relaxer & sleeping: my muscles were more relaxed, & my whole body felt like it'd gotten a bit of a break

i've taken sumac at least 8 times since then on at least 5 different days (this time by modifying this sumac tart recipe to include a lot of sumac powder in the crust, which has been much more enjoyable than the Glass O' Sediment lmao) & adjusting for factors like weather, the effect has been comparable every time:

i watched Inception on the couch with my husband, & understood when she explained things to me

i watched leverage on the couch all day when it was below freezing

i worked a bit on fanfics i've barely been able to touch in a year

i "meal prepped" measuring spices, gathering ingredients, & soaking beans to make beans & rice in the instant pot later that day. i literally can't remember the last time i was able to use my instant pot, after thinking about it i think it was when i made palak paneer last summer, but that was a one-off special occasion thing, i've used it maybe 3 other times since developing ME

i wrote this post

the science:

okay a lot of this shit was over my head before i developed ME so i'm gonna be summarizing at my level lol, look to @lakeeffectbitch for a higher-level analysis

but what i do know! (all images from "The malic acid inhibiting inflammation in ankylosing spondylitis by interfering M1 macrophage polarization" by Ji et al., January 2025)

sumac contains high levels of malic acid, which is found in certain fruits (apples, peaches, etc)

the drugs.com page classifies malic acid as an inactive ingredient, so there are no known drug interactions

mice with ankylosing spondylitis had lower levels of peripheral malic acid than control mice

ID: bar graph showing mice with AS had about 0.03 micromoles per milliliter of peripheral malic acid, compared to the control mice level of over 0.2 micromoles per milliliter. the difference is labeled significant via asterisks. end ID

mice with higher malic acid concentrations had lower ESR and CRP (inflammation markers)

ID: two graphs showing lines with a downward slope. the top graph, ESR versus malic acid concentration, is labeled: r=-0.6802, 95% confidence interval =-0.8843 – -0.2578, p=-0.0053. the graph shows ESR, an inflammation marker, decreasing as malic acid concentration increases. the bottom graph, CRP versus malic acid concentration, is labeled: r=-0.6068, 95% confidence interval =-0.8537 – -0.1371, p=-0.0165. the graph shows CRP, an inflammation marker, decreasing as malic acid concentration increases. end ID

mice treated with malic acid had lower levels of TNF-alpha than the mice with untreated ankylosing spondylitis. humira & similar biologics that treat autoimmune diseases are TNF-alpha blockers

ID: a bar graph of relative mRNA expression of TNF-alpha. M0, the control mice, has a relative expression of 1. M1, the mice with ankylosing spondylitis that did not receive treatment, has a relative expression of slightly less than 4.5. M1+MA, the mice with ankylosing spondylitis who received the malic acid treatment, has a relative expression slightly less than 3. this indicates that the mice treated with malic acid had lower expression of TNF-alpha than the untreated mice. asterisks between M0 and M1 and between M1 and M1+MA indicate significance. end ID

the mitochondrial function of M2 macrophages in mice treated with malic acid "was significantly enhanced"

analysis of the mice's spinal tissue blew my fucking socks off. trying not to jump to conclusions & i know journal articles are full of errors but that looks potentially disease-modifying.

ID: a 5x3 presentation of samples of mouse spinal tissue. the control mice, which are healthy, have thick, undamaged, glowing tissue. the mice with ankylosing spondylitis have thin, curved, cracked-looking tissue. the mice treated with celecoxib, a common prescription NSAID for arthritis, appear very similar to the untreated mice. the mice treated with 250mg/kg of malic acid per day have tissue in between the untreated and healthy appearances; the tissue is "glowing" like the healthy tissue but still narrower and curved, although less so than the untreated tissue. the mice treated with 500mg/kg of malic acid per day have tissue which looks even closer to the healthy appearance, with less curvature than the other treatment groups. end ID

since i started drafting this post i've started taking these malic acid supplements from Nature's Life – the full dose made me feel weird including some heartburn so i cut the capsules & take roughly 2/3 – 3/4 of it at a time (i drop the rest into a spare pill jar to make more doses from). it's been similarly effective for me

please be aware that the supplement instructions say to only take it once a day, i haven't had any issues but everybody is different & this avenue is definitely under-researched! (the mice were given 250mg/kg per day which for me would be like 27 grams but i am not a mouse lol)

[deathmetalunicorn1]

Can you write more for CAW-Macrophage!Reader?

YES!!! Let’s go!!

-You were one of the caregivers at the Valhalla daycare, watching over the younger children who all adored you, finding you so sweet and nice, as you were always smiling and talking with such a sweet voice.

-You were happy to do work like this, protecting children, as it made you feel so warm and cozy on the inside, and many others liked seeing you tending to children, seeing how maternal and motherly you were- they wanted to see that with their own children with you, if you would only give them a chance!!

-It was no secret that many did admire you for not only your delicate looks and kind nature, but you were a powerful warrior, one that could handle even the strongest of the gods! But you always refused any proposals or declarations of love!!

-You were so perfect! WHY DID YOU REFUSE THEM?!?!

-The answer was quite simple, you were already taken, but you were private about it, not wanting others to go after your lover, despite him being able to handle himself. He was the only man who approached trying to befriend you, not like the others who just wanted to immediately get with you.

-You didn’t mind those who approached wanting to spar with you, as they wanted to test their skills, which you had no issues doing, enjoying the workout, but that’s all they really wanted- to test your fighting skills.

-Buddha was your lover and he thought it was amusing to watch you refuse all who came to you, begging for your love, as he had it all to himself, except for the children you watched over and your own ‘son’ whom you adopted, Zerofuku who was in on the secret with Buddha, thinking it was funny that his mama was already taken.

-However, there was a day when one of your pushy suitors didn’t take kindly to your rejection and tried to attack the daycare you worked at.

-Your students stared out the window in awe as you pulled out a giant hammer with spikes and quickly went on the attack, all while smiling like normally, looking so bright and cheerful.

-When he was finally down and you were covered in blood, you turned, hearing your students calling your name, and you beamed brightly with a hand coming to cup your face, “Ara~ara~ looks like I overdid it again~~”

-Buddha had gone to intervene, as he had been passing by, going to drop off sweets to the kids, but he enjoyed the show, watching the awestruck looks of the other suitors who saw you easily put this cocky god in his place, and was quickly roaring with laughter.

-You weren’t to be messed with, especially with those you care about, unless if they wanted a major ass beating.

[ntls-24722]

originally the title for smallest MM in my roster went to this one DJMM that was literally just a peacock spider but the latest bot in town swipes that title right out from beneath all 8 of his feet

( i understand a macrophage would be significantly smaller than him, but)

he wins at a mere half a millimeter. so small

When he is not delivering medicine and getting beat up by people's immune systems he finds himself in his own moss patch, hanging out with other tardigrades. he talks to them but he doesn't realize that the other tardigrades are not quite as intelligent as he is.

[casually tears your face apart]

TEEHEEHEE THE ANTENNAE COILING <33333 WJSBRUWNSOFBWH

okay so 2 things

A. even though Volupe is named after the very pretty Chrysilla Volupe, Volupe is in fact not inspired off of that spider, but Giant Spider Fritz is

B. okay so. there is such a really unique bit of intimacy with the Giant Spider Fritz AU not just because Fritz is finally the perfect size for loving on Comet but also because Fritz has fallen in love with Comet partially because of what Comet is.

Being near Comet, from Fritz's perspective is a very interesting experience to be around because Comet is just so massive that he can feel his heartbeat through the floor near him, the boom in his breath and voice and the melodies his body naturally produces that is also incredibly unique and alien to him leaves him fascinated even when he wasn't in love and now that he is, he has this appreciation for Comet's body that makes him find Comet very beautiful and getting to have and being those traits that he thought was utterly divine on Comet is an experience that is, erm, gonna make him stupid lovesick

that and Fritz just thinks giant spiders are cool and now that he's one, the planet is at his mercy. His larger than life body now holds his larger than life personality.

also, comet, despite being afraid of giant spiders would find fritz's bright colors very attractive. very conflicting emotions for my guy here

bonus loverboy

he looks exactly like his original sketch but younger and with little glasses on. clark kent method

[robinlmaoo]

SO I WAS PLAYING WITH A PICREW AND HAD A BRAINWAVE

i present to you…

cells at work ✨MAGIC AU✨

ok i know this may sound absurd (and not medically accurate at ALL) but hear me out

picrew link btwwww: https://picrew.me/en/image_maker/22819

ramble under the cut:

The Body

The Body is a vast magical kingdom inhabited by many different types of Cells (what the inhabitants of this world are called). The Cells work in tandem to keep their kingdom up and running, with each cell having their own unique role to play. Monsters sometimes come through rips in space-time that sometimes appear in the sky, or through the portals which the kingdom attains its fuels and nutrients its needs to survive. So, the Cells have to be ever vigilant against these foreign invaders lest they seek a bit of their flesh too.

Here are just some of the residents of this strange world:

B-Cells (also known as Plasma Cells)

(this is my oc, b-1808…)

B cells are magic warriors who shoot holy/magic water (antibodies) from their palms at monsters (bacteria) to vanquish them. basically hydrokinesis but antibodies! They are often seen with Memory Cells in battle, who I will elaborate more on in the next part:

Memory B Cells (or just memory cells)

(this is my other oc, N-1712)

Memory Cells are long-lived acolytes that dedicate their entire lives to studying past attacks on the kingdom by foreign invaders and remembering information on them to help the immune system (The Body’s defence force, basically) fight them off better in the future.

1196 and 1146 respectively! (i’m sorry they didn’t have black eye color so i had to settle for the darkest which was purple 😭

Neutrophils (more commonly known by the umbrella term White Blood Cells) are ghost-like warriors who can warp their body into a cloud of mist-like substance to engulf bacteria, destroying them from the outside in. This often grotesque process is known as phagocytosis. Many of them also carry with them blades to subdue their opponents before “eating��� them. The morbidity of the way they fight leads many cells in the body to be afraid of them, and this is the reason why there is a lot of stigma and discrimination surrounding Neutrophils.

Red Blood Cells (also known as Erythrocytes)

aa1253 and ae3803 ^^

For a long time, it was thought that Red Blood Cells were just ordinary cells who just so happened to like the colour red way more than the average Cell does. Turns out, they’re the only race of Cell who can carry one of the most important fuel substances for The Body to sustain itself— Oxygen. Many other cells simply cannot even handle this curious substance, with it slipping between their hands like air, but only, and only Red Blood Cells seem to carry it with ease. That is why they run around The Body, delivering Oxygen that comes from The Lungs, to other organs who need this vital resource to keep running.

Not only are Erythrocytes couriers of Oxygen, they possess a curious ability to kill off foreign invaders using the oxygen they have on hand— if any Erythrocyte is brave enough to walk up to a bacteria to challenge it, anyway. This process has been coined Oxycytosis, though many Red Blood Cells dislike doing this as it robs them of their precious oxygen and they have to go all the way back to The Lungs to get another batch of it.

Macrophage

Macrophages live complicated lives. For one, you can see them caring for and raising young blood cells in the nurseries of the Bone Marrow, but then you can also find them around the body ruthlessly killing off any foreign invaders who dare to harm the body they reside in. They have the ability of phagocytosis too, though it is not as well known as Neutrophil’s phagocytosis.

Dendritic Cell

These kinds of cells are kind of like messengers, relaying information between the active and innate immune system, like from Macrophage to Helper T Cell. They can be activated using Polysaccharides made from Lactic Acid Bacteria, and that allows them to in turn, activate other cells, releasing cytokines to “motivate” them to fight harder.

It is noteworthy that they also possess some fighting capability themselves, as immune cells, so they are not one to be kicked around!

Eosinophil’s phagocytosis and Bacteria/Virus fighting capabilities may pale in comparison to those of other immune cells, but don’t underestimate her. She eliminates a whole different kind of pathogen other white blood cells can’t eliminate— parasites, like Anisakis etc.

Ok that’s it i’m tired you get more another day bye

[kingmacrophage]

Do YOU have a slime? Do YOU wish to see licensed slime girls daily?? Do YOU wanna see Winnie doing something SPECIFIC??? If you answered YES to any of these questions, hit up my ask box! Daily Slime Suggestions are open, and I MAY do some. Possibly. If I feel like it AND remember to screencap the thing.

[phoenixfire-thewizardgoddess]

CELLS at WORK is on aussie netflix

I've always thought it was a fun little anime, and there are three manga series (CaW Baby, CaW and I think there's one called Cells at Work: Code Black that I only got to read a bit of once)

It's fun and I tell you what I would love to be a Macrophage they're gorgeous and proficient with weaponry

Yes, it occasionally pauses to give a basic overview of biology and processes you might know already but it's fun and cute

I lost the series dvd in the fire, so it was a fun surprise to find it on netflix today, because its hard to get now. hope they get season 2, i never got to watch it

[mleprae]

"When I started learning immunology, I stumbled across this curious type of protein complexes that form holes on the cell membrane. I didn't believe it at first because the idea of some protein that insert and create a physical opening on the membrane to leak out all the cellular contents is absolutely wild. To my curious young mind, it is a proper offensive weapon! There are two major types of membrane pore forming complexes: The Membrane Attack Complex (MAC) that is formed by the Complement system, and The pore forming complex by the Gasdermin protein family. The first clip is an example of the Gasdermin pore, specifically Gasdermin B, formed by the oligomerisation of multiple GasderminB proteins (PDB ID: 8GTN). The longer protruding part is where it inserts itself into a lipid membrane. When a cell is infected with pathogens like bacteria, the Gasdermin protein inside that cell is activated by Granzyme A released by Natural Killer cell. Gasdermin then inserts itself to the cell's plasma membrane and form holes. These holes lead to the release of inflammatory molecules and also cause the cell to burst open (pyroptosis, an example for this can be seen in one of my previous videos!), halting the spread of pathogens. Gasdermin B, however, is a special type of Gasdermin where they directly form holes on the bacteria's cell membrane, not the host cell! It is so far the only type that is known for doing this. The electron image at the end is taken from an interesting paper published in the journal EMBO entitled: Mechanism of membrane pore formation by human Gasdermin-D. You can really see the holes formed in the artificial lipid membrane! Go check it out! Pore forming protein complexes are now being explored as a therapy for essentially bursting open cancer cells too! How cool?!!"

-- I got permmission to share this from Bicosmos on instagram here, they also asked me to plug their YT as well if you wanna check out! They do a lot of cool videos on macrophages and cancer.

I was already aware of gasdermin but I never really thought much about it's use, it pokes holes in the cell, essentially killing it and stopping the reproduction of the pathogen inside it. Immune cells react very violently to the presence of dead cells as well, so it's content being spilled out attract them to the site of where this is happening. This also forces the pathogen out, helping the immune cells to engage with it, where they would not be able to if they were inside another cell.

[centers-for-disease-control]

Hi!!! You help control diseases, right? I need advice! So I’m a macrophage, and earlier today I phagocytosed some bacteria I found near the intestinal epithelium. I thought I would be able to get rid of them no problem, but for some reason I can’t seem to kill them??? They’re just sitting there in my phagosome just—aaaaaaaah, I think they’re starting to divide now! Help!!!

Have you asked them to not?

[kirby-the-gorb]

reply roundup!

I've done basically nothing but lay down and be exhausted since kirb2k over 2 months ago, but I did at least get the kirbox orders fulfilled. I have an immunology appointment in another 2 1/2 months and maybe they might do something to help me feel better. (it's a bad time. I know it seems to be most of what I talk about, but it is kind of all-consuming. even this roundup wore me out.)

also there are sometimes comments that make me smile but I don't have anything to add to them so I just read them and smile and don't put them in the roundups, but I promise I do see them all, like the many yeehaws (and yes haws and heehaws) for [cowboy kirb] <3

on [the last roundup] @hive-heart said: Hope things get better, kirby guy 💕 thanks for the reply :) also yeah! Sitting by the window during a storm is quite nice

they haven't lol, but thank you!

on [kirb2k] @ceylonsilvergirl said: HAPPY Y2K EVERYBODY!! I am joke, but it did give me serious “turn of the century’’ vibes. oof… that sentence hit me like I drank out of the wrong grail

that was intentional, that's also why we started with the macarena in the 1990s :>

on [errands] @crypptiid said: ME! MY ROLLATOR IS BLUE AND EVERUTHING @sunflowerinthemidst said: oh look it's me only my walker is hot pink 1😅😂

nice! I should really repaint mine if I'm ever feeling well enough lol

on [the last roundup] @gudetamalover said: :O!!! I’ve been noticed! My surgery went very well btw, thank you! [details removed for privacy.] I love your art so much btw, it brings me and my mom so much joy! I love this little pink dude, he’s got a permanent place in my heart ❤️ 

man that sounds rough, good thing it got ironed out quickly! and I'm glad it brings you both joy <3

on [errands] @pilcherthegreat said: oooo might add this one to my Kirby brigade tattoo 👀

oh hell yeah that sounds so cool! (for anyone else wondering, tattoos on your own body count as personal use and are totally fine by me!)

on [screaming] @persimmonlions said: i always forget how much i do not like the chaotic cacophony of a crowd until i am in a mall, like ‘oh yeah i DO get overstimulated no wonder i constantly skipped classes when i was 10’. anyway i got back home at 3 and proceeded to sleep for 6 hours

ugh omg yeah especially when you actually reblogged this 2 months ago and there were still holiday crowds and all the extra decor and stuff, the mall can be So Much.

on [macarena] @unconventionalvoidaxolotls said: holy heck, go kirby go! oh yeah this is a great first post. beautiful

ehehehe it's an honor :3

on [plushies] @the-void-is-a-disappointment said: finally getting around to reblogging this but thank you bunches for the commission!he looks so comfy and cozy i love it, he deserves this

he does! he does deserve to be so cozy and cute! (and thank you again for the support!)

on [bloodstream] @lord-chiopet said: Kirby in my blood could fix me

well he certainly wouldn't make me worse lol (fun fact: you kind of already have a bunch of kirb-likes in your blood! macrophages are a type of white blood cell that engulf and isolate or destroy foreign matter like splinters, viruses, and even tattoo ink! they're basically eating anything that tries to get into your blood that's not supposed to be there -u- )

on [fire] @jupiterlandings said: kirby I am hurrying to you with blankets and a tent and a warm meal, we may be in the wilderness kirby but we can still look at the stars even when the night is cold. and even if we can’t see them they’re still there and they’ll send the sun to look after us tomorrow. it’ll be ok kirby we’ll be ok

waah this is just such a sweet thought ;n; thank you for sharing it.

on [frown] @shapeshifterwithafez said: get well soon OP :c <3 this kirby nevertheless brings joy to my dashboard thank you!

I will not but thank you! I'm glad he brings joy regardless :)

on [worm] @thecosmickitty said: Hey fam just wanna say i love your art. Thank you for sharing (:

aww thanks!

on [mcas] @untoldsoup said: Im sorry about the health issues 😞 hope you get the treatment your looking for

I appreciate it <3 it's still gonna take a while one way or the other, but hopefully eventually someone will do something.

on [float (up)] @ceylonsilvergirl [added] a ufo to abduct him, then on [rainbow] they [added] an alien kirb to greet him, and on [freckles] they [added] the view out the ufo window :) this little saga was very cute and did cheer me up a bit, thank you <3

on [float (down)] @angst-and-fajitas said: Ah he's floatin away

the kirb's not made for helium balloons! (a reference to [this vine], and good news this upload is actually from the person that made it!)

on [sacrifice] @joekingv1 said: *sits next to baby and waits to see what happens*

I really wanna draw a short comic for this but it seems like I'm not gonna feel up to it anytime soon -n-

on [stars] @gidkog said: *GASP* at world’s ass…

oh no you're right :x that was not on purpose lol

on [earring] @roboticutie said: yay!!!! he's here again today :D thank you!!!

your enthusiasm is sweet! he will be here every day! :)

on [sora] @ducksandlemonsandbigoldfish said: Kiev Kernel Kirby I hate autocorrect

this made me laugh lol

on [sora] @canvascoloredin said: congratulations! I've played all the kingdom hearts games (except Melody of Memories, Sorry Kairi), and started when I was around six but haven't had the time to buy a console I can play 3 on. Have fun for me!

I haven't played melody of memories yet either, the rhythm for all the rhythm minigames was always so janky that I'm kind of worried about how it might play tbh. but I am having lots of fun, I'm sure it's enough for both of us!

on [tattoos] @theraphos said: high five kirby i just recently resolved to finally get myself a tattoo this year also

nice! I hope it goes well :)

@turpial-thoughts asked: hi

hello!

on [worry] @graycoin said: I hope the wait is worth it.

yeah me too :s (thanks. and for all your other sympathetic comments whenever I complain about it as well <3 )

on [float (side)] @joekingv1 said: *asks baby what they think about when they go floating*

probably very little I imagine. even less than usual lol

on [bread] @joekingv1 said: *asks baby what they got while secretly hiding some extra treats for baby, Bear and Cake*

this one is just very cute, I had to read it aloud to my partner when I saw it.

on [sea] @graycoin said: This gets across the vibe very well. I get why you'd feel that way, I think. It's understandable. I'm glad people are trying. You deserve it.

thanks. I've always had a hard time conveying like, internal stuff for some reason, so it's nice when it seems to make sense to someone else.

on [sea] @ceylonsilvergirl said: Kirbo is in the storm, tossed by the waves, threatened by lightning at any moment in the dark. not even the stars to shine through the clouds. but he’s still floating, and that has to count for something

surely it must count for something TnT <3

[averinna]

NKT human au again where as kids, Killer T had a crush on this super cute next door who always looked angry but constantly wore the cutest clothes ever. And one day she move out with her family, breaking his heart.

Year later the girl who's obviously NK come back to town and Killer T can't stand her so there's an obvious rival to lover upcoming

Killer T find himself attracted to her while he thought he had other taste for women while for NK she feel free to experiment what she want to wear now that her big sister, Macrophage, can't use her as a doll anymore

And shenanigan ensue

[beelibub]

The betrayal of the cellular white knight.. Abel. A note who tried to change the chord of his ballad.

Pardon my scribbles and thoughts; they are a little disorganized.

Cell man woo!:

Abel is a character I conjured while in the depths of organic chemistry. I haven't had time to make him a pretty ref, so he just gets a doodle for now! He is a humanoid white blood cell (originally a T cell/messenger cell and thus him having wings) for a massive celestial creature. Cells are sworn to protect their kingdom, their creature, and work as one hive mind.

Lore barf?:

But.. what happens when you wish to sing a tune different from your choir? While he fiercely guards how he and the plague became one, it has been said that he is now highly mutated, and cannot be recognized by his kingdom anymore. He is a foreign entity, a virus himself. He orchestrated the fall of his host body, seeking to "free" more cellular creatures. He continues to travel from celestial to celestial, slowly destroying kingdoms and raising an army of his fellow corrupted celestial knights.

Or so that's how the legend goes. When asked himself, he seems to cry in a way, shaking, his rarely heard voice cracking as he utters "I just wish to be loved despite these demons who have changed my face. I gained independence, at the price of my love. I wish for a home who would welcome me, despite my mutations. If that means I must forge that home myself, then so be it."

Some world building/physiology:

-All white blood knights are given protein keys. the key shape differs based on what celestial they belong to, just like a lock and a key are unique to one another. This is how knights recognize one another should a knight act suspicious. If a suspicious entity is found, the key will morph into a sword, enabling the knight to slice down the pathogen.

-Abel's key is mutated and broken; it may morph to fit into any entity, however, the cross on his chest (the "lock" of all knights) is where the virus resides, and had heavily mutated the recognition point.

-Abel's body may change depending on what cell white blood cell type he is seeking to embody; ex: T cell= big wings, Macrophage= large and beastly, natural killer=simple armour and large blades, ect.

-He is quiet, violent, but tries his best to be kind. He simply wants community again; he is not seeking to be a godslayer. However, his crimes cannot be merely dismissed.

-the ring on his back displays proteins from pathogens

Thank you for listening to me talk about my cell dude that I randomly made! ❤️ You're amazing!

[devintrinidad]

OH MY GOD THESE TAGS!??!?! WHAT IS HE DOING TO MY GIRL????? (Im intrigued)

I thought u meant 4948/3803 with the war au but knowing that it's 1146 instead makes me support it more!!! I just didn't want my babies to hurt but if it's 1146 getting his ass beat then I'm all for it 🫦 3803/1146 angst is so 💥💥💥💥💥

OKGgahshwyx THESE ARE SO ADORABLE. I love how they said 2001 would wouldn't talk to her much but would feed her instead. It's so grandma coded of him LMAOOO

OH MY GOD YOUR SCENARIO OF 5100 AND THE BOYS!!!I AM GONNA THINK ABOUT THAT FOR A WHILE!! I completely agree with everything u said about their dynamic. 2626 would instantly sing her frozen's Lost in the Woods under her window while 2048 would have a petty neighbours rivarly arc with her (if they were to live in the same complex.)

AWWWW NK LIKES CUTE STUFF?? I LOVE THIS!!! No wonder she likes Eosinophil as well.

MACROPHAGE/2001/BASOPHIL POLY OMG YOU ARE A *GENIUS* YESYEYS I SUPPORT THIS. The hotness levels are off charts.

2001 doesn't tell anyone about it. It's not that he is shy like 1146. He just... doesn't. No one asked so he didn't say anything.

As for basophil, he would never outright say it. Every now and then he'd drop a piece of info about his relationship status and you have to connect all of the clues to complete his story like a game npc

Macrophage told ppl about her boyfriends but no one realized she is talking about 2001 and basophil despite her straight up saying she is dating a basophil and a wbc bc no one expected these two losers to score the baddest cell in the body

Thanks to you as well and have a good day!!

Horrible things! That’s what he’s gonna do! Horrible things!

Oh my gosh, I made a mistake! It’s not 1146, it’s actually 4989! It’s an older fic—still on my ffnet account hahaha

(I’m actually not the biggest fan of 1146/3803 if you could believe that. It’s cute and I do ship it, but it’s not my number one: 4989/3803 is).

Heheheh 2001 is definitely world’s best grandma/grandpa!

There’s like canon art of NK in the macrophage’s outfit! It’s really cute and I think she was blushing too!

And yes!!! Basophil and 2001 would either be so white or so vague about who the third is in their relationship that everyone just gets so confused that it’s actually Macrophage!

Have you ever drawn CAW fanart? I think you’re a fan artist, right?

[didanawisgi]

I may be wrong, but I now feel that we are finally approaching the end phase of this pandemic!

Until recently, highly COVID-19 (C-19)–vaccinated populations have primarily exerted adaptive immune pressure on viral infectiousness, leading to the emergence of variants capable of evading virus-neutralizing antibodies (Abs) targeting specific spike (S) protein peptide epitopes. However, highly C-19-vaccinated populations now appear to be shifting toward exerting innate immune pressure on viral trans infectiousness¹, resulting in the emergence of variants (e.g., NB.1.8.1) that can–at least to some extent– evade virus-inhibiting interactions with dendritic cell-expressed lectins, which nonspecifically recognize S-associated glycan motifs. While earlier (adaptive) immune escape variants primarily caused vaccine breakthrough infections resulting in enhanced viral infection rates, these newer (innate) immune escape variants are more likely to cause ‘high-viral-load’ breakthrough infections in individuals with poorly trained cell-mediated innate immunity, potentially leading to increased rates of highly virulent infections—associated with severe disease and death—in highly C-19-vaccinated populations.

So I wouldn’t be surprised if we start the summer with a nasty surprise…

1

Viral trans infectiousness refers to the ability of a virus to infect new host cells indirectly via interactions with host immune cells, such as dendritic cells, rather than through direct infection of target cells. It typically implies a process where:

Antigen-presenting cells (especially dendritic cells or macrophages) capture viral particles at mucosal surfaces via lectin receptors (e.g., DC-SIGN), not to become productively infected themselves, but rather to transfer the virus to permissive target host cells. This lectin-mediated transfer mechanism is often referred to as viral trans infection. Trans infection facilitates intra-host transmission of SARS-CoV-2 and promotes cell-to-cell fusion (so-called trans fusion), leading to the formation of syncytia—structures that are considered pathognomonic of viral virulence. In the context of SARS-CoV-2, migratory dendritic cells (DCs) patrolling the upper respiratory tract can bind spike protein–associated glycans via cell surface-expressed, nonspecific pattern recognition receptors (e.g., C-type lectins), facilitating indirect viral transmission to ACE2-expressing host cells.

This mechanism would bypass traditional neutralization by anti-spike antibodies targeting peptide epitopes, contributing to innate immune escape.

The distinction from viral infectiousness is important when discussing immune escape, as the current evolution of SARS-CoV-2 appears to reflect a shift from adaptive immune evasion (antibody/epitope specificity) toward innate immune evasion. In the case of SARS-CoV-2, innate immune evasion is thought to be due to the diminished capacity of circulating escape mutants to induce inflammatory cytokines and/or interferons (particularly type I interferons such as IFN-α and IFN-β), which are known to upregulate the expression of C-type lectins on the surface of migratory DCs (pattern recognition receptor evasion).